CISD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.58349886
2signal peptide processing (GO:0006465)5.24109740
3polyketide metabolic process (GO:0030638)4.71172415
4doxorubicin metabolic process (GO:0044598)4.71172415
5daunorubicin metabolic process (GO:0044597)4.71172415
6cullin deneddylation (GO:0010388)4.60190523
7ribosomal small subunit assembly (GO:0000028)4.56936970
8protein deneddylation (GO:0000338)4.51778791
9protein neddylation (GO:0045116)4.39414887
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.32618949
11cytochrome complex assembly (GO:0017004)4.07757749
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.04620655
13neutrophil activation involved in immune response (GO:0002283)3.95528078
14chromatin remodeling at centromere (GO:0031055)3.92647755
15CENP-A containing nucleosome assembly (GO:0034080)3.85717904
16respiratory chain complex IV assembly (GO:0008535)3.85269543
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.84374683
18termination of RNA polymerase III transcription (GO:0006386)3.78074739
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.78074739
20positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76294708
21establishment of integrated proviral latency (GO:0075713)3.75847685
22response to interferon-beta (GO:0035456)3.75821072
23nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.74501906
24water-soluble vitamin biosynthetic process (GO:0042364)3.74411764
25DNA deamination (GO:0045006)3.71903928
26regulation of cellular amino acid metabolic process (GO:0006521)3.70708160
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.70654524
28protein complex biogenesis (GO:0070271)3.66742836
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.66626580
30negative regulation of ligase activity (GO:0051352)3.66626580
31DNA double-strand break processing (GO:0000729)3.59496643
32anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.59268376
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.50243464
34aminoglycoside antibiotic metabolic process (GO:0030647)3.48990239
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.47606838
36cotranslational protein targeting to membrane (GO:0006613)3.42750883
37respiratory burst (GO:0045730)3.42430225
38protein targeting to ER (GO:0045047)3.37642393
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.36237235
40purine-containing compound salvage (GO:0043101)3.36029532
41L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.36018588
42myeloid dendritic cell activation (GO:0001773)3.33520089
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.33341799
44NADH dehydrogenase complex assembly (GO:0010257)3.33341799
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.33341799
46signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.30966436
47signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.30966436
48signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.30966436
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29566102
50mitochondrial respiratory chain complex assembly (GO:0033108)3.29393097
51positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.28807425
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27918937
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27918937
54protein localization to endoplasmic reticulum (GO:0070972)3.27573692
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.24630779
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.24630779
57establishment of protein localization to endoplasmic reticulum (GO:0072599)3.22889100
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22570865
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22570865
60cellular response to zinc ion (GO:0071294)3.19313203
61histone exchange (GO:0043486)3.19256646
62regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18645686
63regulation of mitotic spindle checkpoint (GO:1903504)3.18645686
64respiratory electron transport chain (GO:0022904)3.17947192
65establishment of viral latency (GO:0019043)3.16751956
66signal transduction involved in DNA damage checkpoint (GO:0072422)3.16717678
67signal transduction involved in DNA integrity checkpoint (GO:0072401)3.16717678
68deoxyribose phosphate biosynthetic process (GO:0046385)3.15891982
692-deoxyribonucleotide biosynthetic process (GO:0009265)3.15891982
70cellular response to interferon-beta (GO:0035458)3.15271603
71DNA catabolic process, exonucleolytic (GO:0000738)3.14955290
72DNA damage response, detection of DNA damage (GO:0042769)3.14829941
73signal transduction involved in cell cycle checkpoint (GO:0072395)3.14409084
74protein localization to mitochondrion (GO:0070585)3.14289020
75energy coupled proton transport, down electrochemical gradient (GO:0015985)3.13555076
76ATP synthesis coupled proton transport (GO:0015986)3.13555076
77positive regulation of ligase activity (GO:0051351)3.12791865
78establishment of protein localization to mitochondrion (GO:0072655)3.11510477
79electron transport chain (GO:0022900)3.08658696
80mast cell activation (GO:0045576)3.07267147
81rRNA modification (GO:0000154)3.05937193
82antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.05492606
83telomere maintenance via semi-conservative replication (GO:0032201)3.04257709
84viral transcription (GO:0019083)3.04241453
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.03959157
86purine nucleobase biosynthetic process (GO:0009113)3.02269229
87mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01435972
88pseudouridine synthesis (GO:0001522)3.01090980
89translational termination (GO:0006415)2.99939800
90regulation of ubiquitin-protein transferase activity (GO:0051438)2.99642780
91protein-cofactor linkage (GO:0018065)2.97792852
92defense response to protozoan (GO:0042832)2.97233662
93pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96346024
94antigen processing and presentation of endogenous antigen (GO:0019883)2.93720484
95DNA replication checkpoint (GO:0000076)2.93131475
96myeloid dendritic cell differentiation (GO:0043011)2.91532120
97oxidative phosphorylation (GO:0006119)2.91526567
98protein localization to kinetochore (GO:0034501)2.88602854
99regulation of ligase activity (GO:0051340)2.87384904
100pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.87146366
101production of molecular mediator involved in inflammatory response (GO:0002532)2.86098246
102inner mitochondrial membrane organization (GO:0007007)2.85816868
103nucleobase-containing small molecule interconversion (GO:0015949)2.85675712
104histone mRNA metabolic process (GO:0008334)2.82448081
105regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.82165903
106deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.81662044
107telomere maintenance via recombination (GO:0000722)2.81444218
108necroptotic process (GO:0070266)2.80742463
109spliceosomal snRNP assembly (GO:0000387)2.79635079
110hydrogen ion transmembrane transport (GO:1902600)2.79442229
111DNA replication-independent nucleosome organization (GO:0034724)2.79422876
112DNA replication-independent nucleosome assembly (GO:0006336)2.79422876
113proteasome assembly (GO:0043248)2.76363548
114GMP metabolic process (GO:0046037)2.76335168
115quinone biosynthetic process (GO:1901663)2.75686552
116ubiquinone biosynthetic process (GO:0006744)2.75686552
117positive regulation of gamma-delta T cell activation (GO:0046645)2.75535713
118nucleobase biosynthetic process (GO:0046112)2.75477779
119mannosylation (GO:0097502)2.73670458
120chaperone-mediated protein transport (GO:0072321)2.73189942
121endosome to pigment granule transport (GO:0043485)2.73002679
122endosome to melanosome transport (GO:0035646)2.73002679
123regulation of cellular amine metabolic process (GO:0033238)2.72652024
124organelle disassembly (GO:1903008)2.72315996
125aerobic respiration (GO:0009060)2.72011881
126superoxide anion generation (GO:0042554)2.67430770
127L-serine metabolic process (GO:0006563)2.67256537
128DNA ligation (GO:0006266)2.67213290
129mitochondrial transport (GO:0006839)2.66826711
130response to protozoan (GO:0001562)2.66563446
131deoxyribonucleotide biosynthetic process (GO:0009263)2.66405627
132DNA strand elongation involved in DNA replication (GO:0006271)2.65562680
133reactive oxygen species biosynthetic process (GO:1903409)2.63974963
134DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.61354988
135translational elongation (GO:0006414)2.60652549
136cellular response to exogenous dsRNA (GO:0071360)2.60556604
137iron-sulfur cluster assembly (GO:0016226)2.60479706
138metallo-sulfur cluster assembly (GO:0031163)2.60479706
139peptidyl-histidine modification (GO:0018202)2.60375390
140ATP biosynthetic process (GO:0006754)2.60295947
141heart contraction (GO:0060047)2.59792822
142heart process (GO:0003015)2.59792822
143regulation of mitochondrial translation (GO:0070129)2.59233708
144neutrophil activation (GO:0042119)2.58008592
145antigen processing and presentation via MHC class Ib (GO:0002475)2.54717920
146sequestering of metal ion (GO:0051238)2.53427422
147DNA strand elongation (GO:0022616)2.52423646
148ubiquinone metabolic process (GO:0006743)2.51824326
149intracellular pH reduction (GO:0051452)2.51566423
150Arp2/3 complex-mediated actin nucleation (GO:0034314)2.51301517
151dendritic cell differentiation (GO:0097028)2.51031103
152positive regulation of B cell differentiation (GO:0045579)2.47831796
153antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.46832068
154guanosine-containing compound biosynthetic process (GO:1901070)2.46821209
155Peyers patch development (GO:0048541)2.43106370
156mucosal-associated lymphoid tissue development (GO:0048537)2.43106370
157programmed necrotic cell death (GO:0097300)2.42562961
158platelet dense granule organization (GO:0060155)2.41409218
159negative regulation of myeloid cell apoptotic process (GO:0033033)2.39145756
160positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.38508828
161positive regulation of macrophage differentiation (GO:0045651)2.38244583
162protein targeting to mitochondrion (GO:0006626)2.38077653
163granulocyte activation (GO:0036230)2.37029655
164viral life cycle (GO:0019058)2.35622048
165amino acid salvage (GO:0043102)2.34576603
166L-methionine salvage (GO:0071267)2.34576603
167L-methionine biosynthetic process (GO:0071265)2.34576603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.80860751
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.74793652
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50353112
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.46501300
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.15128997
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.05805814
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.04517723
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.91314409
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.89579919
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.79301084
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.74486033
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.71195073
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.65016052
14FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.53434131
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.46391344
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44717153
17* VDR_23849224_ChIP-Seq_CD4+_Human2.43295139
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.42430587
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41942347
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.39875032
21HOXB4_20404135_ChIP-ChIP_EML_Mouse2.39026921
22FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.36302912
23ERG_20887958_ChIP-Seq_HPC-7_Mouse2.33823766
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.29728060
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.28923273
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24676600
27E2F7_22180533_ChIP-Seq_HELA_Human2.24531952
28SPI1_23547873_ChIP-Seq_NB4_Human2.13235034
29ELK1_19687146_ChIP-ChIP_HELA_Human2.13170486
30MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11459703
31GATA1_22025678_ChIP-Seq_K562_Human2.11069974
32ETS1_20019798_ChIP-Seq_JURKAT_Human2.09865048
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09314679
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02762731
35SCL_19346495_ChIP-Seq_HPC-7_Human2.00176133
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99042512
37SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.95527879
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93811998
39* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91565819
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.90433745
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88758839
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87222038
43* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84264144
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.81722593
45DCP1A_22483619_ChIP-Seq_HELA_Human1.81530247
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.80700555
47ZNF274_21170338_ChIP-Seq_K562_Hela1.80112449
48MYC_18940864_ChIP-ChIP_HL60_Human1.78209935
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74564532
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72870186
51* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71456943
52GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.70855504
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69192723
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.67609380
55VDR_22108803_ChIP-Seq_LS180_Human1.66736444
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.66343136
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65516495
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61944025
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60383175
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58192775
61FOXP3_21729870_ChIP-Seq_TREG_Human1.56873408
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54703101
63EWS_26573619_Chip-Seq_HEK293_Human1.54090413
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53729306
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.48527490
66FUS_26573619_Chip-Seq_HEK293_Human1.45652776
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43236807
68IRF1_19129219_ChIP-ChIP_H3396_Human1.42049045
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40089181
70IGF1R_20145208_ChIP-Seq_DFB_Human1.39715478
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39100833
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37657953
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36072748
74MYB_26560356_Chip-Seq_TH2_Human1.34679388
75GABP_19822575_ChIP-Seq_HepG2_Human1.33080055
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31640153
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30359332
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26932752
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26140348
80XRN2_22483619_ChIP-Seq_HELA_Human1.23788956
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22885661
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22507541
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.20832681
84VDR_24763502_ChIP-Seq_THP-1_Human1.18603992
85* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17568410
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16880191
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15466380
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15274419
89ELK1_22589737_ChIP-Seq_MCF10A_Human1.14846877
90NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14697925
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14413519
92TAF15_26573619_Chip-Seq_HEK293_Human1.13900725
93AR_21909140_ChIP-Seq_LNCAP_Human1.13370801
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13331819
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12603448
96RUNX1_22412390_ChIP-Seq_EML_Mouse1.12425738
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12129151
98GATA3_26560356_Chip-Seq_TH2_Human1.10635804
99* TTF2_22483619_ChIP-Seq_HELA_Human1.09633045
100SALL1_21062744_ChIP-ChIP_HESCs_Human1.08850246
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08062301
102STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07816369
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07293880
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07196269
105ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07090109
106P300_19829295_ChIP-Seq_ESCs_Human1.06642503
107TP53_22573176_ChIP-Seq_HFKS_Human1.06301557
108NANOG_16153702_ChIP-ChIP_HESCs_Human1.06199295
109GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06126461
110GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04393795
111PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03087359
112SOX2_16153702_ChIP-ChIP_HESCs_Human1.02727177
113HTT_18923047_ChIP-ChIP_STHdh_Human1.01834394
114YY1_21170310_ChIP-Seq_MESCs_Mouse1.01760837
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01527932
116POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01523588
117PU_27001747_Chip-Seq_BMDM_Mouse1.00529782
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99109996
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99033589
120MYB_26560356_Chip-Seq_TH1_Human0.98559233
121RUNX_20019798_ChIP-Seq_JUKART_Human0.98552859
122FOXM1_23109430_ChIP-Seq_U2OS_Human0.97336528
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97241755
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96712347
125RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94617439
126HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93305388
127CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92668879
128KDM5A_27292631_Chip-Seq_BREAST_Human0.92581330
129CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92432046
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90636992
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90289894
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89823396
133BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88461008
134VDR_21846776_ChIP-Seq_THP-1_Human0.87944742
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87672516
136PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87584568
137EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87500534
138GATA3_27048872_Chip-Seq_THYMUS_Human0.87001352
139FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86848867
140* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86777149
141TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86069081
142E2F1_21310950_ChIP-Seq_MCF-7_Human0.86068698
143FOXA1_25329375_ChIP-Seq_VCAP_Human0.85550395
144FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85550395
145NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84490706
146CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83843379
147FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83089147
148CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82776084
149PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82386848
150ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82044853
151SOX17_20123909_ChIP-Seq_XEN_Mouse0.79324962
152NFE2_27457419_Chip-Seq_LIVER_Mouse0.77675452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.90812358
2MP0008058_abnormal_DNA_repair3.49314700
3MP0002102_abnormal_ear_morphology3.17094025
4MP0005671_abnormal_response_to3.06722294
5MP0009785_altered_susceptibility_to3.02605266
6MP0008877_abnormal_DNA_methylation2.98881569
7MP0002148_abnormal_hypersensitivity_rea2.86305564
8MP0004147_increased_porphyrin_level2.84023215
9MP0003724_increased_susceptibility_to2.82421276
10MP0003646_muscle_fatigue2.66174978
11MP0003436_decreased_susceptibility_to2.62047236
12MP0000685_abnormal_immune_system2.55248340
13MP0001529_abnormal_vocalization2.53864638
14MP0003806_abnormal_nucleotide_metabolis2.53064315
15MP0004957_abnormal_blastocyst_morpholog2.44609843
16MP0005025_abnormal_response_to2.38228786
17MP0005000_abnormal_immune_tolerance2.33026075
18MP0003787_abnormal_imprinting2.25453738
19MP0006072_abnormal_retinal_apoptosis2.23812493
20MP0003718_maternal_effect2.22347367
21MP0002419_abnormal_innate_immunity2.20364147
22MP0005387_immune_system_phenotype2.17657778
23MP0001790_abnormal_immune_system2.17657778
24MP0001984_abnormal_olfaction2.14074209
25MP0001800_abnormal_humoral_immune2.08379299
26MP0002723_abnormal_immune_serum2.07266586
27MP0003111_abnormal_nucleus_morphology2.07121446
28MP0002452_abnormal_antigen_presenting2.03903768
29MP0001853_heart_inflammation2.02621090
30MP0002420_abnormal_adaptive_immunity1.94273530
31MP0001819_abnormal_immune_cell1.93014576
32MP0008932_abnormal_embryonic_tissue1.91392525
33* MP0006036_abnormal_mitochondrial_physio1.88584676
34MP0003121_genomic_imprinting1.86186387
35MP0003656_abnormal_erythrocyte_physiolo1.84585321
36MP0006082_CNS_inflammation1.80259011
37MP0008007_abnormal_cellular_replicative1.80128817
38MP0009379_abnormal_foot_pigmentation1.77581788
39MP0005464_abnormal_platelet_physiology1.76324082
40MP0002396_abnormal_hematopoietic_system1.74595792
41MP0003123_paternal_imprinting1.72005848
42MP0002398_abnormal_bone_marrow1.70201078
43MP0006276_abnormal_autonomic_nervous1.70151326
44MP0003077_abnormal_cell_cycle1.69679530
45MP0009046_muscle_twitch1.67218072
46MP0002938_white_spotting1.63783068
47MP0003186_abnormal_redox_activity1.63553629
48MP0003122_maternal_imprinting1.63473307
49MP0008789_abnormal_olfactory_epithelium1.62980885
50MP0003763_abnormal_thymus_physiology1.62221087
51MP0001986_abnormal_taste_sensitivity1.61989799
52MP0003011_delayed_dark_adaptation1.61773533
53MP0000716_abnormal_immune_system1.59286318
54MP0002736_abnormal_nociception_after1.57032497
55MP0002163_abnormal_gland_morphology1.55923771
56MP0001764_abnormal_homeostasis1.55638548
57MP0001845_abnormal_inflammatory_respons1.55623133
58MP0004510_myositis1.55393324
59MP0001293_anophthalmia1.55274212
60MP0006054_spinal_hemorrhage1.54581784
61MP0009333_abnormal_splenocyte_physiolog1.51003416
62MP0008469_abnormal_protein_level1.49468659
63MP0001188_hyperpigmentation1.48774219
64MP0008004_abnormal_stomach_pH1.48750688
65MP0002876_abnormal_thyroid_physiology1.43963822
66MP0005551_abnormal_eye_electrophysiolog1.43396698
67MP0004808_abnormal_hematopoietic_stem1.42812624
68MP0002429_abnormal_blood_cell1.40942024
69MP0000689_abnormal_spleen_morphology1.39252209
70MP0000343_altered_response_to1.39152686
71* MP0003786_premature_aging1.38174816
72MP0005253_abnormal_eye_physiology1.37740521
73MP0003183_abnormal_peptide_metabolism1.35935143
74MP0005084_abnormal_gallbladder_morpholo1.32140974
75MP0002722_abnormal_immune_system1.31159204
76MP0010386_abnormal_urinary_bladder1.27357936
77* MP0002090_abnormal_vision1.23028006
78MP0008057_abnormal_DNA_replication1.22830323
79MP0004142_abnormal_muscle_tone1.22491716
80MP0002405_respiratory_system_inflammati1.22279194
81MP0002095_abnormal_skin_pigmentation1.21747340
82MP0005394_taste/olfaction_phenotype1.21564881
83MP0005499_abnormal_olfactory_system1.21564881
84MP0004043_abnormal_pH_regulation1.21385281
85MP0005332_abnormal_amino_acid1.19778084
86MP0008875_abnormal_xenobiotic_pharmacok1.19659219
87MP0003195_calcinosis1.19328195
88MP0003303_peritoneal_inflammation1.19230764
89MP0009697_abnormal_copulation1.17423833
90MP0005379_endocrine/exocrine_gland_phen1.16252356
91MP0005075_abnormal_melanosome_morpholog1.16168372
92MP0003941_abnormal_skin_development1.15355492
93MP0004215_abnormal_myocardial_fiber1.15195703
94MP0010155_abnormal_intestine_physiology1.15088651
95MP0002735_abnormal_chemical_nociception1.13908242
96MP0003890_abnormal_embryonic-extraembry1.13512624
97MP0009764_decreased_sensitivity_to1.13006252
98MP0003567_abnormal_fetal_cardiomyocyte1.12954569
99MP0001968_abnormal_touch/_nociception1.12784007
100MP0001533_abnormal_skeleton_physiology1.12234996
101MP0001324_abnormal_eye_pigmentation1.09681049
102* MP0000358_abnormal_cell_content/1.09611133
103* MP0003866_abnormal_defecation1.09340564
104MP0000490_abnormal_crypts_of1.09325794
105MP0002166_altered_tumor_susceptibility1.09323119
106MP0003221_abnormal_cardiomyocyte_apopto1.06369602
107MP0002751_abnormal_autonomic_nervous1.06282064
108MP0005636_abnormal_mineral_homeostasis1.06210163
109MP0003943_abnormal_hepatobiliary_system1.05069352
110MP0005174_abnormal_tail_pigmentation1.04263683
111MP0001905_abnormal_dopamine_level1.04218989
112MP0002160_abnormal_reproductive_system1.03611377
113MP0002272_abnormal_nervous_system1.03318130
114MP0002006_tumorigenesis1.03138319
115* MP0002693_abnormal_pancreas_physiology1.02773836
116MP0005058_abnormal_lysosome_morphology1.02517723
117MP0002210_abnormal_sex_determination1.02357108
118MP0004133_heterotaxia1.01506233
119MP0002638_abnormal_pupillary_reflex1.00175361
120MP0008872_abnormal_physiological_respon0.99318681
121MP0003136_yellow_coat_color0.98892607
122MP0008995_early_reproductive_senescence0.98787243
123MP0004782_abnormal_surfactant_physiolog0.98559549
124MP0000647_abnormal_sebaceous_gland0.98375205
125MP0006292_abnormal_olfactory_placode0.98237637
126MP0001545_abnormal_hematopoietic_system0.96962592
127MP0005397_hematopoietic_system_phenotyp0.96962592
128MP0005310_abnormal_salivary_gland0.96192842
129MP0001929_abnormal_gametogenesis0.93579763
130MP0005408_hypopigmentation0.92745430
131MP0009745_abnormal_behavioral_response0.90403857
132MP0002234_abnormal_pharynx_morphology0.89878298
133MP0001873_stomach_inflammation0.89872722
134MP0000653_abnormal_sex_gland0.89503764
135MP0002837_dystrophic_cardiac_calcinosis0.88574533
136MP0002933_joint_inflammation0.88077224
137MP0003693_abnormal_embryo_hatching0.87225126
138MP0000465_gastrointestinal_hemorrhage0.87096114
139MP0003880_abnormal_central_pattern0.86879596
140MP0005584_abnormal_enzyme/coenzyme_acti0.86802643
141MP0001485_abnormal_pinna_reflex0.86469527
142MP0008775_abnormal_heart_ventricle0.85384413
143MP0005389_reproductive_system_phenotype0.85337982
144MP0001145_abnormal_male_reproductive0.85129640
145MP0004084_abnormal_cardiac_muscle0.85106406
146MP0001663_abnormal_digestive_system0.84917308
147MP0003828_pulmonary_edema0.84674977
148MP0001879_abnormal_lymphatic_vessel0.84650472
149MP0002277_abnormal_respiratory_mucosa0.84456592
150MP0000703_abnormal_thymus_morphology0.83004626
151MP0002653_abnormal_ependyma_morphology0.81401106
152* MP0006035_abnormal_mitochondrial_morpho0.81114295
153MP0005220_abnormal_exocrine_pancreas0.80140459
154MP0008260_abnormal_autophagy0.80114632
155MP0000631_abnormal_neuroendocrine_gland0.79606224
156MP0005645_abnormal_hypothalamus_physiol0.79286510
157MP0005410_abnormal_fertilization0.75905207
158MP0003868_abnormal_feces_composition0.73796439
159MP0000681_abnormal_thyroid_gland0.73689462
160MP0000015_abnormal_ear_pigmentation0.73682812
161MP0010094_abnormal_chromosome_stability0.71651290
162MP0004036_abnormal_muscle_relaxation0.71406297
163MP0002138_abnormal_hepatobiliary_system0.71225624
164MP0005646_abnormal_pituitary_gland0.70927974
165MP0003698_abnormal_male_reproductive0.70903119
166MP0005266_abnormal_metabolism0.70753787
167MP0000372_irregular_coat_pigmentation0.70463352
168MP0003937_abnormal_limbs/digits/tail_de0.68752509
169MP0005391_vision/eye_phenotype0.68346895
170MP0005395_other_phenotype0.67726424
171* MP0002229_neurodegeneration0.66921804
172MP0002233_abnormal_nose_morphology0.66851224
173MP0001697_abnormal_embryo_size0.66258294
174MP0001919_abnormal_reproductive_system0.65009921
175MP0001119_abnormal_female_reproductive0.64978942
176MP0002139_abnormal_hepatobiliary_system0.64535959

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)4.55808242
2Hepatic necrosis (HP:0002605)4.47451436
3Abnormal mitochondria in muscle tissue (HP:0008316)4.06027254
4Acute necrotizing encephalopathy (HP:0006965)4.02088088
5Mitochondrial inheritance (HP:0001427)4.00669916
6Increased CSF lactate (HP:0002490)3.69134380
7Decreased activity of mitochondrial respiratory chain (HP:0008972)3.53231612
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.53231612
9Acute encephalopathy (HP:0006846)3.47480001
10Generalized aminoaciduria (HP:0002909)3.39446400
11Increased intramyocellular lipid droplets (HP:0012240)3.36539665
12Increased hepatocellular lipid droplets (HP:0006565)3.34752929
13Progressive macrocephaly (HP:0004481)3.34741527
14Recurrent abscess formation (HP:0002722)3.32734189
15Abnormal number of erythroid precursors (HP:0012131)3.30846689
16Lipid accumulation in hepatocytes (HP:0006561)3.29853968
17Increased muscle lipid content (HP:0009058)3.05702691
18Abnormality of cells of the erythroid lineage (HP:0012130)3.00680277
19Hyperalaninemia (HP:0003348)2.99562194
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.99562194
21Abnormality of alanine metabolism (HP:0010916)2.99562194
22Thrombocytosis (HP:0001894)2.96253937
23Increased serum lactate (HP:0002151)2.95520806
24Recurrent bacterial skin infections (HP:0005406)2.93198555
25Renal Fanconi syndrome (HP:0001994)2.90956098
26Eczematoid dermatitis (HP:0000976)2.89686787
27Abnormality of the heme biosynthetic pathway (HP:0010472)2.89671386
28Lactic acidosis (HP:0003128)2.85201055
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.78713547
30Methylmalonic aciduria (HP:0012120)2.77655485
31Reduced antithrombin III activity (HP:0001976)2.76570704
32Elevated erythrocyte sedimentation rate (HP:0003565)2.73389316
33Degeneration of anterior horn cells (HP:0002398)2.71210514
34Abnormality of the anterior horn cell (HP:0006802)2.71210514
35Aplastic anemia (HP:0001915)2.71199421
36Exertional dyspnea (HP:0002875)2.68025831
37Abnormality of the labia minora (HP:0012880)2.67133213
38Hyperglycinemia (HP:0002154)2.65099305
393-Methylglutaconic aciduria (HP:0003535)2.64974670
40Recurrent gram-negative bacterial infections (HP:0005420)2.64194325
41Myositis (HP:0100614)2.62943364
42Exercise intolerance (HP:0003546)2.62929725
43Increased serum pyruvate (HP:0003542)2.58242426
44Abnormality of glycolysis (HP:0004366)2.58242426
45Chronic otitis media (HP:0000389)2.54596638
46Neoplasm of head and neck (HP:0012288)2.52091374
47Esophageal neoplasm (HP:0100751)2.52091374
48Abnormality of serum amino acid levels (HP:0003112)2.49242343
49IgM deficiency (HP:0002850)2.47642513
50Abnormality of methionine metabolism (HP:0010901)2.45106768
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.45105237
52Hypothermia (HP:0002045)2.44266331
53Microvesicular hepatic steatosis (HP:0001414)2.43257918
54Type I transferrin isoform profile (HP:0003642)2.42559153
55Cerebral edema (HP:0002181)2.40736820
56Lethargy (HP:0001254)2.39569403
57Pancreatic fibrosis (HP:0100732)2.37813257
58Medial flaring of the eyebrow (HP:0010747)2.34076848
59Respiratory failure (HP:0002878)2.33529291
60Vacuolated lymphocytes (HP:0001922)2.29791955
61Increased neuronal autofluorescent lipopigment (HP:0002074)2.29537564
62Colon cancer (HP:0003003)2.28812032
63Neuroendocrine neoplasm (HP:0100634)2.25709891
64Leukodystrophy (HP:0002415)2.24786469
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23727721
66Abnormality of B cell number (HP:0010975)2.21896162
67B lymphocytopenia (HP:0010976)2.21896162
68Poor head control (HP:0002421)2.20436433
69Molar tooth sign on MRI (HP:0002419)2.19823329
70Abnormality of midbrain morphology (HP:0002418)2.19823329
71Optic disc pallor (HP:0000543)2.17631489
72Petechiae (HP:0000967)2.17078547
73Abnormal protein glycosylation (HP:0012346)2.16269431
74Abnormal glycosylation (HP:0012345)2.16269431
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16269431
76Abnormal protein N-linked glycosylation (HP:0012347)2.16269431
77Congenital primary aphakia (HP:0007707)2.15705878
78Gastrointestinal stroma tumor (HP:0100723)2.14265488
79Recurrent viral infections (HP:0004429)2.14206822
80Respiratory difficulties (HP:0002880)2.12787936
81Hypoglycemic seizures (HP:0002173)2.12390233
82Gait imbalance (HP:0002141)2.11010962
83Abnormality of renal resorption (HP:0011038)2.10410062
84Glycosuria (HP:0003076)2.08983310
85Abnormality of urine glucose concentration (HP:0011016)2.08983310
86Recurrent skin infections (HP:0001581)2.08808927
87Hyperinsulinemic hypoglycemia (HP:0000825)2.08180967
88Macrocytic anemia (HP:0001972)2.06956408
89Abnormality of macrophages (HP:0004311)2.06192728
90Cerebral hypomyelination (HP:0006808)2.04214592
91Pallor (HP:0000980)2.04128113
92Mediastinal lymphadenopathy (HP:0100721)2.03117802
93Nephrogenic diabetes insipidus (HP:0009806)2.02920790
94Hypoproteinemia (HP:0003075)2.02760263
95CNS demyelination (HP:0007305)2.01782006
96Retrobulbar optic neuritis (HP:0100654)1.95706752
97Optic neuritis (HP:0100653)1.95706752
98Recurrent fungal infections (HP:0002841)1.95253585
99Pancytopenia (HP:0001876)1.95035103
100Recurrent pneumonia (HP:0006532)1.92622464
101Meckel diverticulum (HP:0002245)1.92214711
102Hyperphosphaturia (HP:0003109)1.91761878
103Obstructive lung disease (HP:0006536)1.91724403
104Chronic obstructive pulmonary disease (HP:0006510)1.91724403
105Severe visual impairment (HP:0001141)1.91338205
106Palpitations (HP:0001962)1.91131695
107Chromsome breakage (HP:0040012)1.91010727
108X-linked dominant inheritance (HP:0001423)1.90192094
109Meningitis (HP:0001287)1.90111614
110Orchitis (HP:0100796)1.88072071
111Epistaxis (HP:0000421)1.87778848
112Gliosis (HP:0002171)1.87576465
113Abnormality of vitamin B metabolism (HP:0004340)1.86458253
114Abnormality of chromosome stability (HP:0003220)1.85903050
115Poor suck (HP:0002033)1.85598890
116Pancreatic cysts (HP:0001737)1.84880968
117Aplasia/hypoplasia of the uterus (HP:0008684)1.84782837
118Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84359295
119Atrophy/Degeneration involving motor neurons (HP:0007373)1.83956278
120Agnosia (HP:0010524)1.83532525
121Abnormality of the vitamin B12 metabolism (HP:0004341)1.82840736
122Vasculitis (HP:0002633)1.82745127
123Abnormality of the ileum (HP:0001549)1.82131940
124Prolonged bleeding time (HP:0003010)1.82010582
125Neutropenia (HP:0001875)1.81640760
126Hypoglycemic coma (HP:0001325)1.81323403
127Aplasia/Hypoplasia of the uvula (HP:0010293)1.80640458
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80320842
129Megaloblastic anemia (HP:0001889)1.79637069
130Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78984701
131Dicarboxylic aciduria (HP:0003215)1.78984701
132Pheochromocytoma (HP:0002666)1.78981361
133Methylmalonic acidemia (HP:0002912)1.78404328
134Sclerocornea (HP:0000647)1.76444638
135Reticulocytopenia (HP:0001896)1.75978848
136Aplasia/Hypoplasia of the sacrum (HP:0008517)1.75537492
137Renal cortical cysts (HP:0000803)1.75185622
138Hypoplasia of the thymus (HP:0000778)1.74212068
139True hermaphroditism (HP:0010459)1.73903942
140Increased cerebral lipofuscin (HP:0011813)1.73599608
141Abnormality of glycine metabolism (HP:0010895)1.73154983
142Abnormality of serine family amino acid metabolism (HP:0010894)1.73154983
143Neoplasm of the adrenal gland (HP:0100631)1.70689539
144Abnormality of the preputium (HP:0100587)1.69408182
145CNS hypomyelination (HP:0003429)1.69144307
146Pancreatic islet-cell hyperplasia (HP:0004510)1.68524632
147Cortical dysplasia (HP:0002539)1.68355565

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.23621522
2STK163.09739838
3TXK2.94698075
4VRK22.83289912
5NME22.65776043
6TRIM282.58644442
7IRAK42.50886728
8NEK12.35632481
9EIF2AK12.23146930
10MAP4K22.16230096
11VRK12.13261059
12TEC2.08299630
13PLK32.04613100
14KIT2.02606502
15WNK32.01811137
16PIM21.99610886
17CDC71.99533035
18MAP4K11.99324642
19MUSK1.97982548
20MAP3K141.96118358
21BCR1.93277088
22CDK191.92173559
23PIK3CG1.88940648
24CDK81.87945618
25EIF2AK31.87308085
26TBK11.84881345
27CASK1.76999418
28SIK31.73025676
29TTK1.68413542
30CCNB11.67145008
31CAMKK21.66303437
32BRSK21.65778139
33MST41.63299027
34PBK1.62687486
35TSSK61.56600219
36IRAK31.53994908
37IKBKE1.53747462
38TNIK1.53367800
39MKNK21.48835105
40MAP3K121.41417864
41BLK1.41162815
42SCYL21.41048185
43ZAP701.38810494
44PLK21.34040087
45SYK1.32757356
46CSNK1G31.31699675
47PLK11.31685352
48BTK1.31203974
49NEK91.30702836
50TAF11.29223026
51DYRK21.26435801
52WEE11.25803804
53BCKDK1.23773189
54CSNK1G21.22762876
55JAK31.22351410
56TYK21.20830630
57LIMK11.20361546
58MYLK1.20277854
59FRK1.18905877
60TLK11.18626019
61FLT31.18374912
62NME11.14811748
63RIPK41.13862202
64MAP2K71.12571107
65CSNK1G11.11855560
66MAP3K41.09298497
67DYRK31.06810047
68MAPKAPK51.06556947
69MAP2K31.05526323
70IKBKB1.03088770
71TGFBR11.02804836
72ERBB30.99627347
73CSNK1A1L0.99377941
74SRPK10.99131460
75IRAK10.98844651
76LYN0.98671211
77RPS6KA40.97917277
78YES10.96126911
79PIK3CA0.93162300
80FES0.93140938
81TIE10.92475057
82TAOK30.89187544
83STK390.89103469
84INSRR0.86115388
85TESK10.84210717
86TGFBR20.83582705
87MINK10.83275945
88BMPR1B0.81263926
89OBSCN0.80179564
90IRAK20.78446721
91GRK10.77605313
92MKNK10.77411340
93BMPR20.76295416
94LCK0.74923711
95ARAF0.74244615
96OXSR10.73842304
97ADRBK20.72960005
98DAPK10.72728360
99ATR0.71347344
100PASK0.71101151
101PRKCG0.70502498
102TESK20.69443829
103AURKB0.69377590
104TNK20.68753617
105GRK50.65993747
106EIF2AK20.65609718
107MATK0.63776201
108CHEK20.63381820
109AURKA0.62013195
110STK38L0.60865967
111NLK0.59785366
112KDR0.57825456
113BRSK10.56454413
114ACVR1B0.56178249
115ABL20.55296205
116CSNK2A20.54430483
117ATM0.52250269
118ITK0.51792317
119STK30.51604232
120PRKCE0.51417451
121PLK40.50122460
122PIM10.49523481
123GRK70.48904074
124NUAK10.47831605
125JAK10.47803613
126WNK40.47296949
127CDK30.45750610
128PAK30.45147038
129PDK20.44975647
130MAPK150.44009144
131PRKG20.42093476
132TRPM70.41779789
133HIPK20.41572684
134MAPK120.40266895
135RPS6KA50.39957101
136CDK140.38853658
137NEK20.37909962
138CSNK1A10.37533292
139JAK20.37287763
140CAMK10.36585938
141CAMK2A0.34739610
142ZAK0.34691085
143CSF1R0.33750408
144LMTK20.33710035
145MAPK130.33527714
146PINK10.33407493
147CSNK1E0.33340193
148ADRBK10.33145990
149CSNK2A10.32053383
150CDK180.31243880
151NEK60.31015228
152STK40.29343771
153ALK0.29122849
154MAP3K50.29010798
155EPHA40.27945092

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.36646999
2Ribosome_Homo sapiens_hsa030103.55432802
3DNA replication_Homo sapiens_hsa030303.48815892
4Oxidative phosphorylation_Homo sapiens_hsa001903.21207622
5Parkinsons disease_Homo sapiens_hsa050122.82696667
6Proteasome_Homo sapiens_hsa030502.81341057
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.61809723
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.23984225
9Mismatch repair_Homo sapiens_hsa034302.08139359
10SNARE interactions in vesicular transport_Homo sapiens_hsa041302.07762264
11Alzheimers disease_Homo sapiens_hsa050102.01018974
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.95757424
13Pyrimidine metabolism_Homo sapiens_hsa002401.95725118
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75403847
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74834543
16RNA polymerase_Homo sapiens_hsa030201.71578065
17Leishmaniasis_Homo sapiens_hsa051401.69388165
18Huntingtons disease_Homo sapiens_hsa050161.65541892
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57349290
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.55517897
21Homologous recombination_Homo sapiens_hsa034401.54909452
22Nucleotide excision repair_Homo sapiens_hsa034201.53851522
23Base excision repair_Homo sapiens_hsa034101.53636010
24Primary immunodeficiency_Homo sapiens_hsa053401.49376536
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48532210
26Caffeine metabolism_Homo sapiens_hsa002321.46513676
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46018027
28Legionellosis_Homo sapiens_hsa051341.45475430
29RNA transport_Homo sapiens_hsa030131.45440302
30Folate biosynthesis_Homo sapiens_hsa007901.43064172
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40474560
32Asthma_Homo sapiens_hsa053101.38999108
33Allograft rejection_Homo sapiens_hsa053301.38853366
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.38610074
35Rheumatoid arthritis_Homo sapiens_hsa053231.36459841
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33681591
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.30541991
38Selenocompound metabolism_Homo sapiens_hsa004501.23217326
39Phagosome_Homo sapiens_hsa041451.20893318
40Steroid biosynthesis_Homo sapiens_hsa001001.19945990
41Sulfur metabolism_Homo sapiens_hsa009201.19659583
42Hematopoietic cell lineage_Homo sapiens_hsa046401.18743076
43Antigen processing and presentation_Homo sapiens_hsa046121.17531436
44Measles_Homo sapiens_hsa051621.16653747
45Butanoate metabolism_Homo sapiens_hsa006501.16504675
46Herpes simplex infection_Homo sapiens_hsa051681.14586151
47Purine metabolism_Homo sapiens_hsa002301.13038951
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12834068
49Spliceosome_Homo sapiens_hsa030401.11534313
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11324365
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10533244
52Vitamin B6 metabolism_Homo sapiens_hsa007501.09308181
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09054561
54Pertussis_Homo sapiens_hsa051331.08246183
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06090262
56Collecting duct acid secretion_Homo sapiens_hsa049661.04358570
57Graft-versus-host disease_Homo sapiens_hsa053321.02272317
58N-Glycan biosynthesis_Homo sapiens_hsa005101.02086089
59Vibrio cholerae infection_Homo sapiens_hsa051100.99803636
60Type I diabetes mellitus_Homo sapiens_hsa049400.99528815
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.96959589
62Glutathione metabolism_Homo sapiens_hsa004800.95619954
63Cardiac muscle contraction_Homo sapiens_hsa042600.95289573
64Tuberculosis_Homo sapiens_hsa051520.93954801
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93041917
66Cell cycle_Homo sapiens_hsa041100.92547476
67RNA degradation_Homo sapiens_hsa030180.91096969
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91002905
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89017133
70Autoimmune thyroid disease_Homo sapiens_hsa053200.88853352
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88300600
72Osteoclast differentiation_Homo sapiens_hsa043800.82945955
73Sulfur relay system_Homo sapiens_hsa041220.81541590
74Peroxisome_Homo sapiens_hsa041460.80751102
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78326631
76Biosynthesis of amino acids_Homo sapiens_hsa012300.76262389
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.75958633
78Tryptophan metabolism_Homo sapiens_hsa003800.70575167
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70568723
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70255508
81Chemical carcinogenesis_Homo sapiens_hsa052040.69718175
82Fatty acid elongation_Homo sapiens_hsa000620.69273249
83Influenza A_Homo sapiens_hsa051640.68777689
84Malaria_Homo sapiens_hsa051440.68192092
85Lysosome_Homo sapiens_hsa041420.68067814
86Regulation of autophagy_Homo sapiens_hsa041400.67346042
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67204513
88Propanoate metabolism_Homo sapiens_hsa006400.66437325
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65964086
90Other glycan degradation_Homo sapiens_hsa005110.65094940
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64770512
92Basal transcription factors_Homo sapiens_hsa030220.63009509
93Oocyte meiosis_Homo sapiens_hsa041140.62717634
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.61758738
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60603471
96Fatty acid metabolism_Homo sapiens_hsa012120.60240198
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57683764
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57125071
99Carbon metabolism_Homo sapiens_hsa012000.57021252
100Nitrogen metabolism_Homo sapiens_hsa009100.56348130
101Retinol metabolism_Homo sapiens_hsa008300.55612883
102Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55319859
103Shigellosis_Homo sapiens_hsa051310.54720764
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.53986302
105beta-Alanine metabolism_Homo sapiens_hsa004100.53333030
106B cell receptor signaling pathway_Homo sapiens_hsa046620.53035755
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52977683
108Metabolic pathways_Homo sapiens_hsa011000.52955550
109Salmonella infection_Homo sapiens_hsa051320.52835522
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.52367059
111Nicotine addiction_Homo sapiens_hsa050330.51364868
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51270044
113Hepatitis B_Homo sapiens_hsa051610.50643677
114Pyruvate metabolism_Homo sapiens_hsa006200.49799317
115Epstein-Barr virus infection_Homo sapiens_hsa051690.49715986
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.49224490
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47873730
118Linoleic acid metabolism_Homo sapiens_hsa005910.47188216
119Ether lipid metabolism_Homo sapiens_hsa005650.46236711
120mRNA surveillance pathway_Homo sapiens_hsa030150.45991627
121Fatty acid degradation_Homo sapiens_hsa000710.45947998
122Arginine and proline metabolism_Homo sapiens_hsa003300.45903559
123Non-homologous end-joining_Homo sapiens_hsa034500.45369933
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44745147
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44489762
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43837363
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43674879
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43381476
129p53 signaling pathway_Homo sapiens_hsa041150.38237721
130Apoptosis_Homo sapiens_hsa042100.37925437
131Synaptic vesicle cycle_Homo sapiens_hsa047210.37525273
132Phototransduction_Homo sapiens_hsa047440.36877719
133Tyrosine metabolism_Homo sapiens_hsa003500.35863422
134Staphylococcus aureus infection_Homo sapiens_hsa051500.33599313
135Fanconi anemia pathway_Homo sapiens_hsa034600.32369682
136TNF signaling pathway_Homo sapiens_hsa046680.31271290
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30557112
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30129431
139One carbon pool by folate_Homo sapiens_hsa006700.29690304
140Chemokine signaling pathway_Homo sapiens_hsa040620.27787582
141Mineral absorption_Homo sapiens_hsa049780.27093198
142Viral myocarditis_Homo sapiens_hsa054160.26767202
143Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26566721
144Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26327050
1452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25368713
146Platelet activation_Homo sapiens_hsa046110.23583582

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