CISH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interleukin-12 biosynthetic process (GO:0045075)4.95077162
2positive regulation of gamma-delta T cell activation (GO:0046645)4.91154062
3negative regulation of cell killing (GO:0031342)4.81633883
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.81633883
5positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.74994425
6antigen processing and presentation of endogenous antigen (GO:0019883)4.70985212
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.61909809
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.60723112
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.60723112
10negative regulation of erythrocyte differentiation (GO:0045647)4.43947209
11negative regulation of T cell mediated immunity (GO:0002710)4.38462413
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.33950049
13negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.02417002
14regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.00340121
15positive regulation of natural killer cell differentiation (GO:0032825)4.00287048
16regulation of gamma-delta T cell differentiation (GO:0045586)3.94178974
17myeloid dendritic cell differentiation (GO:0043011)3.94022766
18positive regulation of immunoglobulin mediated immune response (GO:0002891)3.91410375
19positive regulation of B cell mediated immunity (GO:0002714)3.91410375
20cellular extravasation (GO:0045123)3.85669923
21negative regulation of lymphocyte mediated immunity (GO:0002707)3.84224929
22regulation of gamma-delta T cell activation (GO:0046643)3.82844530
23negative regulation of interleukin-12 production (GO:0032695)3.82056537
24regulation of T-helper 1 cell differentiation (GO:0045625)3.81359780
25regulation of B cell receptor signaling pathway (GO:0050855)3.81155504
26interferon-gamma production (GO:0032609)3.81079924
27regulation of chronic inflammatory response (GO:0002676)3.79943614
28myeloid dendritic cell activation (GO:0001773)3.79681302
29response to interleukin-15 (GO:0070672)3.78239093
30positive regulation of isotype switching (GO:0045830)3.73910670
31positive regulation of humoral immune response (GO:0002922)3.72386168
32positive regulation of granulocyte differentiation (GO:0030854)3.68296376
33leukocyte aggregation (GO:0070486)3.66947434
34regulation of immunoglobulin secretion (GO:0051023)3.64948060
35positive regulation of alpha-beta T cell proliferation (GO:0046641)3.64481377
36positive regulation of interleukin-2 production (GO:0032743)3.60506902
37positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.60304512
38CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.60284078
39detection of bacterium (GO:0016045)3.58920330
40detection of other organism (GO:0098543)3.58410279
41T cell migration (GO:0072678)3.56410407
42regulation of T cell tolerance induction (GO:0002664)3.56176519
43regulation of alpha-beta T cell proliferation (GO:0046640)3.55764103
44* JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.52673853
45defense response to protozoan (GO:0042832)3.51729662
46negative regulation of cytokine production involved in immune response (GO:0002719)3.50857783
47cellular response to interleukin-15 (GO:0071350)3.50399951
48T cell selection (GO:0045058)3.45861590
49regulation of interleukin-2 biosynthetic process (GO:0045076)3.45146005
50negative regulation of leukocyte mediated immunity (GO:0002704)3.42470353
51response to type I interferon (GO:0034340)3.41064668
52cellular response to type I interferon (GO:0071357)3.39542110
53type I interferon signaling pathway (GO:0060337)3.39542110
54activated T cell proliferation (GO:0050798)3.39358793
55response to protozoan (GO:0001562)3.35323312
56regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.34642862
57regulation of natural killer cell mediated immunity (GO:0002715)3.34642862
58T-helper 1 type immune response (GO:0042088)3.34229891
59NIK/NF-kappaB signaling (GO:0038061)3.33619268
60germinal center formation (GO:0002467)3.33291323
61negative thymic T cell selection (GO:0045060)3.31892020
62regulation of isotype switching to IgG isotypes (GO:0048302)3.31632312
63negative T cell selection (GO:0043383)3.28938318
64positive regulation of activated T cell proliferation (GO:0042104)3.28642488
65positive thymic T cell selection (GO:0045059)3.27872490
66response to muramyl dipeptide (GO:0032495)3.27796339
67positive regulation of DNA recombination (GO:0045911)3.27624997
68tolerance induction (GO:0002507)3.25910696
69positive T cell selection (GO:0043368)3.23855011
70mucosal-associated lymphoid tissue development (GO:0048537)3.23169693
71Peyers patch development (GO:0048541)3.23169693
72regulation of interferon-alpha production (GO:0032647)3.22793342
73positive regulation of interferon-alpha production (GO:0032727)3.22725374
74tyrosine phosphorylation of STAT protein (GO:0007260)3.22674042
75interferon-gamma-mediated signaling pathway (GO:0060333)3.22656557
76response to peptidoglycan (GO:0032494)3.20583269
77positive regulation of chemokine biosynthetic process (GO:0045080)3.19974174
78regulation of B cell differentiation (GO:0045577)3.18282553
79regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.17411274
80immunoglobulin mediated immune response (GO:0016064)3.16816108
81regulation of tolerance induction (GO:0002643)3.16166426
82positive regulation of interleukin-12 production (GO:0032735)3.16087066
83regulation of T-helper 1 type immune response (GO:0002825)3.13899793
84regulation of T-helper cell differentiation (GO:0045622)3.10948269
85positive regulation of T-helper 1 type immune response (GO:0002827)3.08876362
86regulation of natural killer cell differentiation (GO:0032823)3.08600885
87T cell homeostasis (GO:0043029)3.08594423
88positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.08556801
89macrophage activation involved in immune response (GO:0002281)3.06336031
90regulation of immunoglobulin mediated immune response (GO:0002889)3.06233623
91CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.06006884
92T-helper cell differentiation (GO:0042093)3.06006884
93neutrophil activation involved in immune response (GO:0002283)3.05037602
94regulation of B cell mediated immunity (GO:0002712)3.04849282
95positive regulation of cytokine biosynthetic process (GO:0042108)3.03657749
96lymphocyte chemotaxis (GO:0048247)3.03469623
97negative regulation of T-helper cell differentiation (GO:0045623)3.01936136
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.01936136
99positive regulation of B cell differentiation (GO:0045579)3.01894227
100positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.99344748
101regulation of regulatory T cell differentiation (GO:0045589)2.98516923
102regulation of response to interferon-gamma (GO:0060330)2.97912573
103positive regulation of type 2 immune response (GO:0002830)2.97339499
104positive regulation of interleukin-17 production (GO:0032740)2.97259448
105positive regulation of macrophage differentiation (GO:0045651)2.96951816
106positive regulation of tolerance induction (GO:0002645)2.96001311
107leukocyte degranulation (GO:0043299)2.93883533
108lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93510794
109regulation of granulocyte differentiation (GO:0030852)2.92363710
110negative regulation of adaptive immune response (GO:0002820)2.92343123
111regulation of interleukin-12 production (GO:0032655)2.91468728
112regulation of interleukin-2 production (GO:0032663)2.90241054
113regulation of chemokine biosynthetic process (GO:0045073)2.89685846
114regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.89440049
115positive regulation of T-helper cell differentiation (GO:0045624)2.88620491
116positive regulation of T cell mediated cytotoxicity (GO:0001916)2.88578482
117negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.88572708
118regulation of isotype switching (GO:0045191)2.86304033
119thymic T cell selection (GO:0045061)2.86291103
120negative regulation of alpha-beta T cell activation (GO:0046636)2.86186056
121regulation of T cell mediated cytotoxicity (GO:0001914)2.85912302
122regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.85679256
123positive regulation of immunoglobulin production (GO:0002639)2.85203618
124dendritic cell differentiation (GO:0097028)2.85136939
125positive regulation of lymphocyte mediated immunity (GO:0002708)2.84865794
126detection of external biotic stimulus (GO:0098581)2.84731663
127regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.84103706
128negative regulation of production of molecular mediator of immune response (GO:0002701)2.83191838
129growth hormone receptor signaling pathway (GO:0060396)2.82911465
130negative regulation of type 2 immune response (GO:0002829)2.82408651
131cellular response to interferon-beta (GO:0035458)2.81453086
132positive regulation of natural killer cell mediated immunity (GO:0002717)2.80199871
133regulation of vitamin D biosynthetic process (GO:0060556)2.79955452
134regulation of type 2 immune response (GO:0002828)2.79467225
135regulation of leukocyte mediated cytotoxicity (GO:0001910)2.78585155
136T cell differentiation involved in immune response (GO:0002292)2.78292430
137alpha-beta T cell differentiation involved in immune response (GO:0002293)2.78292430
138alpha-beta T cell activation involved in immune response (GO:0002287)2.78292430
139regulation of hypersensitivity (GO:0002883)2.76096618
140natural killer cell activation (GO:0030101)2.76080687
141positive regulation by symbiont of host defense response (GO:0052509)2.75433566
142modulation by symbiont of host defense response (GO:0052031)2.75433566
143modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.75433566
144modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.75433566
145positive regulation by organism of defense response of other organism involved in symbiotic interact2.75433566
146modulation by symbiont of host immune response (GO:0052553)2.75433566
147positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.75355162
148positive regulation of interferon-gamma production (GO:0032729)2.75286834
149granulocyte activation (GO:0036230)2.74340284

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.52851218
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.38505587
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.71212050
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.62694042
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.03290213
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.01884974
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.69120732
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.14397624
9* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.13942695
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.12035869
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.94549238
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.82503682
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73683180
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.72897723
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.65833545
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59255625
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54072350
18RUNX_20019798_ChIP-Seq_JUKART_Human2.43331879
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40271749
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.33067191
21MYB_26560356_Chip-Seq_TH2_Human2.31771827
22SCL_19346495_ChIP-Seq_HPC-7_Human2.21942895
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.19213467
24* MAF_26560356_Chip-Seq_TH1_Human2.17265947
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.14944618
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08452090
27* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.00856412
28MYB_26560356_Chip-Seq_TH1_Human1.89636448
29SPI1_23547873_ChIP-Seq_NB4_Human1.87176937
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85670764
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84050522
32E2F7_22180533_ChIP-Seq_HELA_Human1.82154545
33MYC_22102868_ChIP-Seq_BL_Human1.76348468
34VDR_24763502_ChIP-Seq_THP-1_Human1.72970877
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71428007
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.68168057
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66045610
38* VDR_21846776_ChIP-Seq_THP-1_Human1.63529683
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61083929
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.58448939
41UTX_26944678_Chip-Seq_JUKART_Human1.57512991
42TCF7_22412390_ChIP-Seq_EML_Mouse1.56558287
43GATA3_27048872_Chip-Seq_THYMUS_Human1.53840140
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50930615
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42018640
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41403320
47* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39979567
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39377500
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38258594
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37643735
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35196160
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34332021
53PU_27001747_Chip-Seq_BMDM_Mouse1.33887165
54* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33630330
55MAF_26560356_Chip-Seq_TH2_Human1.33595205
56* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32700572
57* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32462566
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31883781
59LXR_22292898_ChIP-Seq_THP-1_Human1.31467985
60* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31147392
61PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31114152
62GATA1_22025678_ChIP-Seq_K562_Human1.31048117
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27245339
64SPI1_23127762_ChIP-Seq_K562_Human1.26460191
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25681577
66* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23868905
67CIITA_25753668_ChIP-Seq_RAJI_Human1.21742363
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20047705
69GATA3_26560356_Chip-Seq_TH2_Human1.19730770
70RXR_22158963_ChIP-Seq_LIVER_Mouse1.14306152
71VDR_24787735_ChIP-Seq_THP-1_Human1.13581864
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.13491393
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12544812
74* GATA1_19941827_ChIP-Seq_MEL_Mouse1.09301277
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.08560310
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06935551
77BCOR_27268052_Chip-Seq_Bcells_Human1.06157016
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06131499
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05131719
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.04505045
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04493758
82* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04043321
83BCL6_27268052_Chip-Seq_Bcells_Human1.03674205
84* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03059230
85FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02297386
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00263817
87KDM2B_26808549_Chip-Seq_JURKAT_Human1.00114051
88CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99456063
89KDM2B_26808549_Chip-Seq_DND41_Human0.97476787
90* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96358047
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96140343
92TFEB_21752829_ChIP-Seq_HELA_Human0.95741470
93PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95334800
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94891575
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94202574
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92852827
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91358127
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91145654
99* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90950384
100* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90142003
101SA1_27219007_Chip-Seq_ERYTHROID_Human0.90059788
102ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88595350
103LXR_22158963_ChIP-Seq_LIVER_Mouse0.87947934
104KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87224742
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85675645
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85675645
107GATA2_19941826_ChIP-Seq_K562_Human0.83931934
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83763199
109GATA1_19941826_ChIP-Seq_K562_Human0.83721013
110PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80518885
111RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78116359
112* NCOR1_26117541_ChIP-Seq_K562_Human0.77637736
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77096307
114NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75626699
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74767897
116HOXB4_20404135_ChIP-ChIP_EML_Mouse0.73883948
117EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.73596482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.20441913
2MP0009785_altered_susceptibility_to3.68179700
3MP0003436_decreased_susceptibility_to3.64485049
4MP0005671_abnormal_response_to3.61542678
5MP0000685_abnormal_immune_system3.29160156
6MP0002148_abnormal_hypersensitivity_rea3.05247790
7MP0005000_abnormal_immune_tolerance2.94057034
8MP0003303_peritoneal_inflammation2.84985170
9MP0005025_abnormal_response_to2.84145389
10MP0006082_CNS_inflammation2.82399793
11MP0004510_myositis2.80667751
12MP0001790_abnormal_immune_system2.78176795
13MP0005387_immune_system_phenotype2.78176795
14MP0003724_increased_susceptibility_to2.76365551
15MP0001853_heart_inflammation2.74777388
16MP0001800_abnormal_humoral_immune2.57943012
17MP0003763_abnormal_thymus_physiology2.46426206
18MP0002723_abnormal_immune_serum2.46094198
19MP0002452_abnormal_antigen_presenting2.36759936
20MP0002419_abnormal_innate_immunity2.36392064
21MP0002405_respiratory_system_inflammati2.24874918
22MP0001819_abnormal_immune_cell2.19049728
23MP0002420_abnormal_adaptive_immunity2.17284367
24MP0003300_gastrointestinal_ulcer2.09395155
25MP0010155_abnormal_intestine_physiology2.08003824
26MP0009333_abnormal_splenocyte_physiolog2.01448765
27MP0004947_skin_inflammation2.00192805
28MP0001845_abnormal_inflammatory_respons1.83932694
29MP0009764_decreased_sensitivity_to1.82788664
30MP0005464_abnormal_platelet_physiology1.82610983
31MP0002398_abnormal_bone_marrow1.82031258
32MP0003866_abnormal_defecation1.74707142
33MP0000716_abnormal_immune_system1.73471993
34MP0002006_tumorigenesis1.73158317
35MP0001533_abnormal_skeleton_physiology1.60546212
36MP0003448_altered_tumor_morphology1.56794514
37MP0005310_abnormal_salivary_gland1.54107736
38MP0008469_abnormal_protein_level1.53265768
39MP0002166_altered_tumor_susceptibility1.51655222
40MP0002722_abnormal_immune_system1.47972354
41MP0002138_abnormal_hepatobiliary_system1.47174930
42MP0001873_stomach_inflammation1.46700932
43MP0001545_abnormal_hematopoietic_system1.44438398
44MP0005397_hematopoietic_system_phenotyp1.44438398
45MP0002429_abnormal_blood_cell1.43150116
46MP0003172_abnormal_lysosome_physiology1.41846982
47MP0004808_abnormal_hematopoietic_stem1.40794728
48MP0000689_abnormal_spleen_morphology1.38729832
49MP0003828_pulmonary_edema1.35002827
50MP0005058_abnormal_lysosome_morphology1.30766365
51MP0000343_altered_response_to1.28925810
52MP0010352_gastrointestinal_tract_polyps1.28535156
53MP0000858_altered_metastatic_potential1.24988999
54MP0000703_abnormal_thymus_morphology1.17075593
55MP0002254_reproductive_system_inflammat1.16594043
56MP0003453_abnormal_keratinocyte_physiol1.13436530
57MP0008260_abnormal_autophagy1.13335164
58MP0009840_abnormal_foam_cell1.11942454
59MP0001348_abnormal_lacrimal_gland1.10095050
60MP0002933_joint_inflammation1.08237772
61MP0009763_increased_sensitivity_to1.07447533
62MP0005083_abnormal_biliary_tract1.01645099
63MP0003806_abnormal_nucleotide_metabolis0.98621515
64MP0000465_gastrointestinal_hemorrhage0.95740626
65MP0001881_abnormal_mammary_gland0.95385317
66MP0001851_eye_inflammation0.94708170
67MP0003941_abnormal_skin_development0.93270189
68MP0009278_abnormal_bone_marrow0.92436380
69MP0003191_abnormal_cellular_cholesterol0.92194452
70MP0005166_decreased_susceptibility_to0.91792596
71MP0002998_abnormal_bone_remodeling0.90993987
72MP0003566_abnormal_cell_adhesion0.88244917
73MP0000490_abnormal_crypts_of0.86929158
74MP0002396_abnormal_hematopoietic_system0.86683984
75MP0004782_abnormal_surfactant_physiolog0.86538734
76MP0002877_abnormal_melanocyte_morpholog0.84757853
77MP0008004_abnormal_stomach_pH0.83495100
78MP0003186_abnormal_redox_activity0.82175061
79MP0002693_abnormal_pancreas_physiology0.81548829
80MP0005451_abnormal_body_composition0.81447309
81MP0003045_fibrosis0.80755960
82MP0000609_abnormal_liver_physiology0.79568183
83MP0008775_abnormal_heart_ventricle0.79231104
84MP0003075_altered_response_to0.79170809
85MP0008057_abnormal_DNA_replication0.78965881
86MP0004381_abnormal_hair_follicle0.77430899
87MP0009765_abnormal_xenobiotic_induced0.77393671
88MP0002132_abnormal_respiratory_system0.77209766
89MP0004084_abnormal_cardiac_muscle0.71967029
90MP0001216_abnormal_epidermal_layer0.71617712
91MP0005165_increased_susceptibility_to0.71229068
92MP0005390_skeleton_phenotype0.67622064
93MP0000604_amyloidosis0.67355559
94MP0005075_abnormal_melanosome_morpholog0.67302202
95MP0000249_abnormal_blood_vessel0.67050991
96MP0000015_abnormal_ear_pigmentation0.65603515
97MP0005076_abnormal_cell_differentiation0.65362418
98MP0004130_abnormal_muscle_cell0.63750749
99MP0005319_abnormal_enzyme/_coenzyme0.63119327
100MP0004185_abnormal_adipocyte_glucose0.63017795
101MP0003646_muscle_fatigue0.62285889
102MP0005023_abnormal_wound_healing0.61890891
103MP0009115_abnormal_fat_cell0.61720853
104MP0002139_abnormal_hepatobiliary_system0.61417113
105MP0002136_abnormal_kidney_physiology0.61115293
106MP0002277_abnormal_respiratory_mucosa0.60382000
107MP0005385_cardiovascular_system_phenoty0.60160884
108MP0001544_abnormal_cardiovascular_syste0.60160884
109MP0003795_abnormal_bone_structure0.58111619
110MP0008995_early_reproductive_senescence0.57035041
111MP0001663_abnormal_digestive_system0.56850058
112MP0000313_abnormal_cell_death0.55504032
113MP0004883_abnormal_blood_vessel0.55475821
114MP0003656_abnormal_erythrocyte_physiolo0.54514142
115MP0002019_abnormal_tumor_incidence0.54244664
116MP0009643_abnormal_urine_homeostasis0.53839542
117MP0005584_abnormal_enzyme/coenzyme_acti0.52881270
118MP0003221_abnormal_cardiomyocyte_apopto0.52633711
119MP0000598_abnormal_liver_morphology0.52467010
120MP0001727_abnormal_embryo_implantation0.51537208
121MP0004147_increased_porphyrin_level0.50261536
122MP0008874_decreased_physiological_sensi0.50089334

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.52831472
2Myositis (HP:0100614)4.88775711
3Elevated erythrocyte sedimentation rate (HP:0003565)4.88410302
4Stomatitis (HP:0010280)4.87492111
5Recurrent abscess formation (HP:0002722)4.69377636
6Retrobulbar optic neuritis (HP:0100654)4.52302579
7Optic neuritis (HP:0100653)4.52302579
8Recurrent bacterial skin infections (HP:0005406)4.52059747
9Recurrent fungal infections (HP:0002841)4.46449930
10Orchitis (HP:0100796)4.42046251
11Recurrent gram-negative bacterial infections (HP:0005420)3.97515257
12Mediastinal lymphadenopathy (HP:0100721)3.96292417
13Abnormality of macrophages (HP:0004311)3.62297747
14Arterial thrombosis (HP:0004420)3.60342458
15Chronic mucocutaneous candidiasis (HP:0002728)3.59376490
16Recurrent cutaneous fungal infections (HP:0011370)3.59376490
17Gastrointestinal infarctions (HP:0005244)3.53735300
18Vasculitis (HP:0002633)3.53033342
19Recurrent skin infections (HP:0001581)3.50476302
20Interstitial pulmonary disease (HP:0006530)3.44376149
21Increased IgM level (HP:0003496)3.32399122
22Recurrent viral infections (HP:0004429)3.31299605
23Chronic otitis media (HP:0000389)3.26093688
24Abnormality of T cell number (HP:0011839)3.19797906
25Thrombocytosis (HP:0001894)3.19732278
26Hemoptysis (HP:0002105)3.14966027
27T lymphocytopenia (HP:0005403)3.14021694
28Pulmonary infiltrates (HP:0002113)3.12724451
29Gingival bleeding (HP:0000225)3.09248409
30Abnormality of T cells (HP:0002843)3.07632168
31Abnormality of the heme biosynthetic pathway (HP:0010472)3.07144975
32Keratoconjunctivitis (HP:0001096)3.06529892
33Granulocytopenia (HP:0001913)3.06310764
34Keratoconjunctivitis sicca (HP:0001097)3.05680756
35Increased IgE level (HP:0003212)3.04955487
36Joint swelling (HP:0001386)3.00121427
37Obstructive lung disease (HP:0006536)2.95932807
38Chronic obstructive pulmonary disease (HP:0006510)2.95932807
39Gingivitis (HP:0000230)2.90237100
40Nasal polyposis (HP:0100582)2.89873224
41Recurrent bronchitis (HP:0002837)2.89450721
42Petechiae (HP:0000967)2.88671682
43Abnormality of T cell physiology (HP:0011840)2.85661505
44Abnormality of the nasal mucosa (HP:0000433)2.84084726
45Hypergammaglobulinemia (HP:0010702)2.83338305
46IgA deficiency (HP:0002720)2.82284402
47Meningitis (HP:0001287)2.82131920
48Pustule (HP:0200039)2.66842262
49Epistaxis (HP:0000421)2.65011197
50Microcytic anemia (HP:0001935)2.64186004
51Autoimmune thrombocytopenia (HP:0001973)2.62094161
52Cellulitis (HP:0100658)2.58699998
53IgM deficiency (HP:0002850)2.57091387
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.57074091
55Hypochromic anemia (HP:0001931)2.56946958
56Increased serum ferritin (HP:0003281)2.53855020
57Chest pain (HP:0100749)2.52683075
58Chronic diarrhea (HP:0002028)2.50166743
59Gangrene (HP:0100758)2.46559180
60Abnormal gallbladder physiology (HP:0012438)2.45755120
61Cholecystitis (HP:0001082)2.45755120
62Spontaneous hematomas (HP:0007420)2.44935121
63Hypochromic microcytic anemia (HP:0004840)2.43975715
64Urticaria (HP:0001025)2.43078970
65Vacuolated lymphocytes (HP:0001922)2.42806742
66Anorexia (HP:0002039)2.42368861
67Eosinophilia (HP:0001880)2.41101175
68Segmental peripheral demyelination/remyelination (HP:0003481)2.40882817
69Prolonged bleeding time (HP:0003010)2.38352261
70Pulmonary embolism (HP:0002204)2.38195496
71Leukocytosis (HP:0001974)2.37770024
72IgG deficiency (HP:0004315)2.34819167
73Polycythemia (HP:0001901)2.34094182
74Hepatosplenomegaly (HP:0001433)2.33238195
75Panhypogammaglobulinemia (HP:0003139)2.33186470
76Abnormality of the fingertips (HP:0001211)2.32255234
77Periodontitis (HP:0000704)2.30794844
78Hypertensive crisis (HP:0100735)2.30754279
79Gastrointestinal stroma tumor (HP:0100723)2.29032005
80Encephalitis (HP:0002383)2.27982577
81Basal ganglia calcification (HP:0002135)2.27729203
82Acne (HP:0001061)2.26112058
83Abnormality of iron homeostasis (HP:0011031)2.25778978
84Inflammation of the large intestine (HP:0002037)2.23033126
85Colitis (HP:0002583)2.22615156
86Lymphopenia (HP:0001888)2.22594210
87Myocardial infarction (HP:0001658)2.21827540
88Esophageal varix (HP:0002040)2.21662667
89Thrombophlebitis (HP:0004418)2.21051209
90Keratitis (HP:0000491)2.17072386
91Cheilitis (HP:0100825)2.16347413
92Acute hepatic failure (HP:0006554)2.15423581
93Abnormality of cells of the lymphoid lineage (HP:0012140)2.15282134
94Severe combined immunodeficiency (HP:0004430)2.14375655
95Polyneuropathy (HP:0001271)2.12880489
96Slow saccadic eye movements (HP:0000514)2.11352482
97Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11213148
98Ventricular tachycardia (HP:0004756)2.09328578
99Episodic fever (HP:0001954)2.09161641
100Gastrointestinal inflammation (HP:0004386)2.09061202
101Reticulocytosis (HP:0001923)2.06496110
102Abnormality of the pericardium (HP:0001697)2.05939829
103Fatigue (HP:0012378)2.02761797
104Abnormality of the endocardium (HP:0004306)2.02276582
105Arthralgia (HP:0002829)2.01435678
106Glomerulopathy (HP:0100820)2.00198098
107Skin ulcer (HP:0200042)2.00168629
108Purpura (HP:0000979)1.98842466
109Impaired platelet aggregation (HP:0003540)1.98798616
110Abnormal platelet function (HP:0011869)1.98798616
111Amaurosis fugax (HP:0100576)1.97813964
112Abnormality of glycolipid metabolism (HP:0010969)1.96017235
113Abnormality of liposaccharide metabolism (HP:0010968)1.96017235
114Abnormality of glycosphingolipid metabolism (HP:0004343)1.96017235
115Combined immunodeficiency (HP:0005387)1.95863063
116Abnormality of the pleura (HP:0002103)1.94143631
117Tetraparesis (HP:0002273)1.92982272
118Osteomyelitis (HP:0002754)1.89835781
119Abnormality of the prostate (HP:0008775)1.88192909
120Vertigo (HP:0002321)1.85228190
121Abnormality of eosinophils (HP:0001879)1.85002077
122Menorrhagia (HP:0000132)1.84569522
123Systemic lupus erythematosus (HP:0002725)1.84302128
124Bilateral sensorineural hearing impairment (HP:0008619)1.80479126
125Autoimmune hemolytic anemia (HP:0001890)1.80233720
126Nausea (HP:0002018)1.78856817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.27129143
2MAP4K14.06936490
3MAP3K143.42389270
4JAK33.39536822
5PRPF4B3.31876771
6TBK13.05384723
7TYK22.69108621
8IRAK32.64856365
9PIM22.52184392
10ZAP702.47035426
11IKBKB2.40055325
12IKBKE2.32023401
13FGFR42.29983247
14BLK2.25294713
15JAK12.06234497
16NME21.92428476
17IRAK41.91187348
18EPHA31.89134679
19BTK1.83757742
20TEC1.83353186
21CHUK1.82792621
22PBK1.78625720
23RIPK41.75038779
24MST41.73291141
25ITK1.72214982
26TRIB31.70009662
27EPHB11.65565410
28ERN11.57597310
29TNK21.52238203
30FGFR31.50742255
31PIM11.48011623
32NEK91.44295361
33SYK1.43335657
34NLK1.42226601
35PKN21.34433457
36SMG11.33664872
37TAOK31.33055946
38JAK21.32748558
39SIK31.32566996
40KSR21.24381699
41LCK1.21737391
42STK101.20043477
43KIT1.17169611
44HCK1.15384308
45MAP3K111.14063867
46MAP2K31.06871369
47CDK121.04031531
48MARK31.03024615
49IRAK10.98945361
50LRRK20.96030271
51STK240.95977339
52CSK0.95210898
53MATK0.92277949
54STK40.91864887
55EEF2K0.90397756
56FLT30.89563291
57RPS6KA40.88865375
58MAPK120.88750284
59TTN0.88662573
60MAP3K50.86144272
61MAPK110.85863561
62FGR0.81623870
63TIE10.79086791
64SIK10.78714987
65LYN0.78625984
66TGFBR20.75226724
67MAP3K80.72440347
68BMPR20.71829607
69RAF10.71571181
70MAP3K130.69266723
71MAP3K30.69058609
72EIF2AK10.68820208
73MAP2K60.67292900
74TESK20.67286246
75MAP3K120.64986153
76YES10.62717410
77TGFBR10.61573537
78RPS6KC10.60607624
79RPS6KL10.60607624
80RIPK10.57896086
81MAP3K10.57866291
82BMX0.57456464
83PTK60.55799849
84PRKCQ0.55509550
85TAOK10.54841202
86MYLK0.54035655
87ICK0.52443709
88KDR0.51586461
89MAPKAPK20.50890448
90TRPM70.50321354
91MAP3K20.50090817
92PDPK10.49630014
93MARK20.48018999
94ALK0.46851830
95SIK20.46343610
96MAP3K60.45711998
97RET0.44583727
98CSF1R0.42867668
99CDK60.42859020
100CAMKK10.40476158
101HIPK20.39770953
102CLK10.39228927
103CDC42BPA0.38573437
104MAP3K100.38417647
105ABL20.37018349
106PRKCD0.35737592
107CAMKK20.35589056
108MAPK30.34633254
109ABL10.33746038
110MST1R0.33114353
111MAP3K70.32679352
112FYN0.32320632
113MAPKAPK30.30364891
114PIK3CG0.30280376
115TAOK20.30189095
116DAPK30.29806794
117PDGFRB0.29133864
118PDK10.28680122
119DYRK1B0.28349275
120RPS6KA10.27966228
121RPS6KA50.27765139
122RPS6KA60.25453831
123GRK60.25049901
124FES0.24646577
125GRK70.24504186
126EIF2AK20.24313556
127TLK10.24182393
128PRKCH0.23626515
129CDK40.22937095

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.73592787
2Graft-versus-host disease_Homo sapiens_hsa053323.72725806
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.36559410
4Asthma_Homo sapiens_hsa053103.15018342
5Leishmaniasis_Homo sapiens_hsa051403.02560713
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.90752855
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.71549675
8Caffeine metabolism_Homo sapiens_hsa002322.64312878
9Measles_Homo sapiens_hsa051622.58993058
10Primary immunodeficiency_Homo sapiens_hsa053402.54017029
11Type I diabetes mellitus_Homo sapiens_hsa049402.43325159
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.38499983
13Autoimmune thyroid disease_Homo sapiens_hsa053202.34175358
14Legionellosis_Homo sapiens_hsa051342.15352169
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.14295801
16Osteoclast differentiation_Homo sapiens_hsa043802.14126694
17* Jak-STAT signaling pathway_Homo sapiens_hsa046302.14039643
18Toll-like receptor signaling pathway_Homo sapiens_hsa046202.13476581
19NOD-like receptor signaling pathway_Homo sapiens_hsa046212.02758112
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.86031739
21TNF signaling pathway_Homo sapiens_hsa046681.80817954
22T cell receptor signaling pathway_Homo sapiens_hsa046601.77767592
23Hematopoietic cell lineage_Homo sapiens_hsa046401.75460944
24Toxoplasmosis_Homo sapiens_hsa051451.70846515
25Rheumatoid arthritis_Homo sapiens_hsa053231.63203403
26Staphylococcus aureus infection_Homo sapiens_hsa051501.61342175
27Influenza A_Homo sapiens_hsa051641.60993507
28Herpes simplex infection_Homo sapiens_hsa051681.60765438
29Malaria_Homo sapiens_hsa051441.58710072
30Pertussis_Homo sapiens_hsa051331.52039811
31Tuberculosis_Homo sapiens_hsa051521.48657474
32Antigen processing and presentation_Homo sapiens_hsa046121.48346220
33Viral myocarditis_Homo sapiens_hsa054161.45386660
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37889552
35B cell receptor signaling pathway_Homo sapiens_hsa046621.33450062
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26413236
37Non-small cell lung cancer_Homo sapiens_hsa052231.23666901
38Acute myeloid leukemia_Homo sapiens_hsa052211.22458812
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19935254
40Chemokine signaling pathway_Homo sapiens_hsa040621.18805131
41Apoptosis_Homo sapiens_hsa042101.17898764
42Salmonella infection_Homo sapiens_hsa051321.12101278
43Hepatitis B_Homo sapiens_hsa051611.08101441
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98113084
45African trypanosomiasis_Homo sapiens_hsa051430.97268048
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.93909792
47* Prolactin signaling pathway_Homo sapiens_hsa049170.90889171
48Hepatitis C_Homo sapiens_hsa051600.89986020
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86929838
50Shigellosis_Homo sapiens_hsa051310.86826396
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.80366179
52Renal cell carcinoma_Homo sapiens_hsa052110.74588856
53Insulin resistance_Homo sapiens_hsa049310.73736065
54mTOR signaling pathway_Homo sapiens_hsa041500.72329560
55Platelet activation_Homo sapiens_hsa046110.66068086
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64272809
57Chronic myeloid leukemia_Homo sapiens_hsa052200.63818081
58Epstein-Barr virus infection_Homo sapiens_hsa051690.63614981
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63114207
60Amoebiasis_Homo sapiens_hsa051460.61351651
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60970659
62HTLV-I infection_Homo sapiens_hsa051660.58614050
63Phagosome_Homo sapiens_hsa041450.54717911
64Lysosome_Homo sapiens_hsa041420.53570727
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.52193211
66HIF-1 signaling pathway_Homo sapiens_hsa040660.50111124
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48683281
68Fructose and mannose metabolism_Homo sapiens_hsa000510.46909145
69Viral carcinogenesis_Homo sapiens_hsa052030.45029556
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43487540
71Endometrial cancer_Homo sapiens_hsa052130.42536200
72Small cell lung cancer_Homo sapiens_hsa052220.42363249
73Thyroid cancer_Homo sapiens_hsa052160.41952862
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41293994
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40900841
76Insulin signaling pathway_Homo sapiens_hsa049100.38905822
77Pancreatic cancer_Homo sapiens_hsa052120.38177220
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37595217
79Dorso-ventral axis formation_Homo sapiens_hsa043200.36903810
80Other glycan degradation_Homo sapiens_hsa005110.36548046
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35734971
82Endocytosis_Homo sapiens_hsa041440.34500697
83Fatty acid degradation_Homo sapiens_hsa000710.34317904
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33560140
85Choline metabolism in cancer_Homo sapiens_hsa052310.33141313
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.31806944
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.28932469
88VEGF signaling pathway_Homo sapiens_hsa043700.28447363
89Prostate cancer_Homo sapiens_hsa052150.28268009
90Complement and coagulation cascades_Homo sapiens_hsa046100.28119823
91Bladder cancer_Homo sapiens_hsa052190.27759684
92ErbB signaling pathway_Homo sapiens_hsa040120.27274340
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.27189998
94Colorectal cancer_Homo sapiens_hsa052100.27056459
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.26395860
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26178881
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25627179
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24146397
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23254927
100p53 signaling pathway_Homo sapiens_hsa041150.23198375
101FoxO signaling pathway_Homo sapiens_hsa040680.22986976
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21938336
103Inositol phosphate metabolism_Homo sapiens_hsa005620.21929307
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.21698490
105Prion diseases_Homo sapiens_hsa050200.21214034
106Type II diabetes mellitus_Homo sapiens_hsa049300.19835636
107Galactose metabolism_Homo sapiens_hsa000520.19495536
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16272367
109Ribosome_Homo sapiens_hsa030100.16110182
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14890155
111Notch signaling pathway_Homo sapiens_hsa043300.14867922
112Tryptophan metabolism_Homo sapiens_hsa003800.14321419
113ABC transporters_Homo sapiens_hsa020100.12536685
114PPAR signaling pathway_Homo sapiens_hsa033200.11546529
115Regulation of autophagy_Homo sapiens_hsa041400.10081475
116Pentose phosphate pathway_Homo sapiens_hsa000300.09471541
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.09199098
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.08616744
119Phenylalanine metabolism_Homo sapiens_hsa003600.08199542
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.03643723
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.03119365
122beta-Alanine metabolism_Homo sapiens_hsa004100.02235158
123MAPK signaling pathway_Homo sapiens_hsa040100.01850183
124Peroxisome_Homo sapiens_hsa041460.01390862

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