CIT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.84400139
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.67426438
3mitotic chromosome condensation (GO:0007076)5.55902881
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.19022655
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.15892044
6* sister chromatid segregation (GO:0000819)5.03999869
7regulation of mitotic spindle organization (GO:0060236)5.03934979
8neuron cell-cell adhesion (GO:0007158)5.03607874
9synaptic vesicle exocytosis (GO:0016079)4.93221968
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.89895603
11DNA unwinding involved in DNA replication (GO:0006268)4.87564646
12locomotory exploration behavior (GO:0035641)4.76783663
13regulation of glutamate receptor signaling pathway (GO:1900449)4.74500051
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.65353777
15nuclear pore complex assembly (GO:0051292)4.65336688
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.58990245
17neurotransmitter secretion (GO:0007269)4.55242567
18synaptic vesicle maturation (GO:0016188)4.51562681
19neuronal action potential propagation (GO:0019227)4.49945441
20regulation of synaptic vesicle exocytosis (GO:2000300)4.42459026
21regulation of spindle organization (GO:0090224)4.37289597
22glutamate secretion (GO:0014047)4.34131821
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.30088699
24synaptic vesicle docking involved in exocytosis (GO:0016081)4.18373278
25protein localization to synapse (GO:0035418)4.17323310
26protein localization to chromosome, centromeric region (GO:0071459)4.16147344
27protein localization to kinetochore (GO:0034501)4.13477449
28gamma-aminobutyric acid transport (GO:0015812)4.11780900
29neurotransmitter-gated ion channel clustering (GO:0072578)4.06614122
30neuron-neuron synaptic transmission (GO:0007270)4.06233986
31gamma-aminobutyric acid signaling pathway (GO:0007214)4.04063498
32mitotic metaphase plate congression (GO:0007080)4.02045281
33nuclear pore organization (GO:0006999)3.98647581
34synaptic transmission, glutamatergic (GO:0035249)3.94252636
35cerebellar Purkinje cell differentiation (GO:0021702)3.91900618
36cellular potassium ion homeostasis (GO:0030007)3.91645541
37regulation of synaptic vesicle transport (GO:1902803)3.88101874
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.86133927
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.85765158
40presynaptic membrane assembly (GO:0097105)3.84570500
41startle response (GO:0001964)3.83996089
42glutamate receptor signaling pathway (GO:0007215)3.83859324
43chromosome condensation (GO:0030261)3.83279254
44sodium ion export (GO:0071436)3.80079035
45transmission of nerve impulse (GO:0019226)3.79233394
46neurotransmitter transport (GO:0006836)3.74128875
47response to histamine (GO:0034776)3.70086516
48regulation of neuronal synaptic plasticity (GO:0048168)3.68818879
49postsynaptic membrane organization (GO:0001941)3.65556294
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.63489308
51mitotic sister chromatid cohesion (GO:0007064)3.63147134
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.61523115
53exploration behavior (GO:0035640)3.58814361
54DNA topological change (GO:0006265)3.55198266
55presynaptic membrane organization (GO:0097090)3.54939521
56metaphase plate congression (GO:0051310)3.54329723
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53073576
58regulation of neurotransmitter levels (GO:0001505)3.49612703
59neuromuscular process controlling posture (GO:0050884)3.48613874
60kinetochore organization (GO:0051383)3.47252021
61long-term memory (GO:0007616)3.45591220
62auditory behavior (GO:0031223)3.43364223
63amino acid import (GO:0043090)3.43063221
64positive regulation of membrane potential (GO:0045838)3.42409778
65regulation of postsynaptic membrane potential (GO:0060078)3.41843471
66pore complex assembly (GO:0046931)3.40498175
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.40018031
68proline transport (GO:0015824)3.38432470
69L-amino acid import (GO:0043092)3.36700082
70establishment of chromosome localization (GO:0051303)3.36495671
71mechanosensory behavior (GO:0007638)3.36317009
72cytoskeletal anchoring at plasma membrane (GO:0007016)3.33971096
73striatum development (GO:0021756)3.32721534
74regulation of protein kinase A signaling (GO:0010738)3.29054022
75positive regulation of synapse assembly (GO:0051965)3.28560977
76positive regulation of synaptic transmission, GABAergic (GO:0032230)3.27544709
77positive regulation of chromosome segregation (GO:0051984)3.27512748
78positive regulation of synapse maturation (GO:0090129)3.26581003
79DNA packaging (GO:0006323)3.24868278
80DNA strand elongation involved in DNA replication (GO:0006271)3.23687946
81long-term synaptic potentiation (GO:0060291)3.22023315
82regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.19610829
83synaptic vesicle endocytosis (GO:0048488)3.17290048
84G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16014770
85DNA strand elongation (GO:0022616)3.14776097
86membrane hyperpolarization (GO:0060081)3.14214823
87protein complex localization (GO:0031503)3.13014106
88regulation of synaptic plasticity (GO:0048167)3.12712995
89* mitotic sister chromatid segregation (GO:0000070)3.11350922
90cerebellar granule cell differentiation (GO:0021707)3.10883695
91regulation of synaptic transmission, GABAergic (GO:0032228)3.10502446
92glycine transport (GO:0015816)3.09964963
93regulation of neurotransmitter secretion (GO:0046928)3.07780028
94neurotransmitter uptake (GO:0001504)3.05836151
95regulation of synapse structural plasticity (GO:0051823)3.04383446
96microtubule depolymerization (GO:0007019)3.04375462
97negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.03361677
98adult walking behavior (GO:0007628)3.03073116
99positive regulation of dendritic spine morphogenesis (GO:0061003)3.01338264
100mitotic cytokinesis (GO:0000281)2.99675502
101positive regulation of neurotransmitter transport (GO:0051590)2.99525381
102neuronal ion channel clustering (GO:0045161)2.99223502
103social behavior (GO:0035176)2.99021376
104intraspecies interaction between organisms (GO:0051703)2.99021376
105* regulation of chromosome segregation (GO:0051983)2.98644833
106mitotic nuclear envelope disassembly (GO:0007077)2.98232418
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98157571
108regulation of glutamate secretion (GO:0014048)2.98093296
109membrane depolarization (GO:0051899)2.97351296
110microtubule polymerization or depolymerization (GO:0031109)2.97026850
111DNA replication initiation (GO:0006270)2.96844474
112behavioral fear response (GO:0001662)2.95999872
113behavioral defense response (GO:0002209)2.95999872
114membrane disassembly (GO:0030397)2.94308853
115nuclear envelope disassembly (GO:0051081)2.94308853
116neuromuscular process controlling balance (GO:0050885)2.91298518
117response to auditory stimulus (GO:0010996)2.90663233
118membrane depolarization during action potential (GO:0086010)2.90005487
119learning (GO:0007612)2.89760931
120dendritic spine morphogenesis (GO:0060997)2.87933924
121* chromosome segregation (GO:0007059)2.87894973
122regulation of sister chromatid cohesion (GO:0007063)2.87716374
123establishment of mitotic spindle localization (GO:0040001)2.87192076
124positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86903537
125regulation of synapse maturation (GO:0090128)2.85953143
126regulation of neurotransmitter transport (GO:0051588)2.85531661
127neuromuscular process (GO:0050905)2.84905210
128neuron recognition (GO:0008038)2.84849943
129synaptic transmission (GO:0007268)2.84720407
130establishment of spindle localization (GO:0051293)2.84449856
131glucocorticoid receptor signaling pathway (GO:0042921)2.81992015
132potassium ion homeostasis (GO:0055075)2.79801896
133telomere maintenance via semi-conservative replication (GO:0032201)2.79628546
134regulation of vesicle fusion (GO:0031338)2.78503381
135G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.78280486
136positive regulation of neurotransmitter secretion (GO:0001956)2.78152289
137synapse assembly (GO:0007416)2.77953518
138positive regulation of synaptic transmission (GO:0050806)2.77436275
139layer formation in cerebral cortex (GO:0021819)2.77174478
140cellular protein complex localization (GO:0034629)2.76895015
141positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.76486063
142regulation of exit from mitosis (GO:0007096)2.74813000
143heterochromatin organization (GO:0070828)2.74768489
144protein localization to chromosome (GO:0034502)2.74500627
145spindle checkpoint (GO:0031577)2.73876792
146regulation of centriole replication (GO:0046599)2.72902845
147fear response (GO:0042596)2.72835221
148negative regulation of amino acid transport (GO:0051956)2.72147505
149regulation of synaptic transmission (GO:0050804)2.71893800
150DNA replication checkpoint (GO:0000076)2.71638834
151cell differentiation in hindbrain (GO:0021533)2.71506083
152meiotic chromosome segregation (GO:0045132)2.71481539
153establishment of integrated proviral latency (GO:0075713)2.70003331
154negative regulation of chromosome segregation (GO:0051985)2.66675307
155regulation of translational fidelity (GO:0006450)2.65863866
156cytoskeleton-dependent cytokinesis (GO:0061640)2.64180214
157DNA conformation change (GO:0071103)2.61903317
158kinetochore assembly (GO:0051382)2.61323370
159DNA ligation (GO:0006266)2.58894020
160DNA duplex unwinding (GO:0032508)2.51870248
161cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.50746662
162regulation of nucleobase-containing compound transport (GO:0032239)2.50097826
163positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.50052359
164positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.50052359
165positive regulation of mitotic sister chromatid separation (GO:1901970)2.50052359
166mitotic spindle checkpoint (GO:0071174)2.49537210
167regulation of mammary gland epithelial cell proliferation (GO:0033599)2.48835080
168negative regulation of mitotic sister chromatid separation (GO:2000816)2.48241765
169negative regulation of sister chromatid segregation (GO:0033046)2.48241765
170negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.48241765
171negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.48241765
172negative regulation of mitotic sister chromatid segregation (GO:0033048)2.48241765
173regulation of centrosome cycle (GO:0046605)2.47644550
174regulation of RNA export from nucleus (GO:0046831)2.47582682
175establishment of spindle orientation (GO:0051294)2.47196075
176protein depolymerization (GO:0051261)2.47192589
177regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.45609169

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.86666280
2GBX2_23144817_ChIP-Seq_PC3_Human3.98421523
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.90611406
4* AR_21909140_ChIP-Seq_LNCAP_Human3.25420475
5REST_21632747_ChIP-Seq_MESCs_Mouse2.78683169
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74137204
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62512533
8TAF15_26573619_Chip-Seq_HEK293_Human2.61803963
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.57537171
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.54036057
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.51482323
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.50772556
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.47696301
14* FOXM1_23109430_ChIP-Seq_U2OS_Human2.46236147
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38002610
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26027393
17* REST_18959480_ChIP-ChIP_MESCs_Mouse2.24431174
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.19396100
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18535666
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15010168
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14997936
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11068598
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.09437834
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09117519
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09117519
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.06298279
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05094325
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00301138
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96396037
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92993194
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92153283
32E2F7_22180533_ChIP-Seq_HELA_Human1.91433333
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87993564
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86358881
35DROSHA_22980978_ChIP-Seq_HELA_Human1.85344996
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82402776
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.81309218
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.80167257
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78468645
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77538874
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.75880053
42FUS_26573619_Chip-Seq_HEK293_Human1.71670892
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.69125871
44SMAD4_21799915_ChIP-Seq_A2780_Human1.66105531
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63079122
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62357681
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59994234
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58388280
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58076740
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54371338
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.53094557
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51502241
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.51236544
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50736735
55ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49016661
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48540510
57RNF2_27304074_Chip-Seq_NSC_Mouse1.46028865
58P300_19829295_ChIP-Seq_ESCs_Human1.42726846
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42139072
60CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39889699
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39815425
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39299994
63* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.38318323
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.38076796
65* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36465354
66* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36126944
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.33515306
68IGF1R_20145208_ChIP-Seq_DFB_Human1.31438095
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30885807
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30773325
71* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30532941
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29650428
73* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29471166
74KDM2B_26808549_Chip-Seq_K562_Human1.28850035
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27420917
76TCF4_23295773_ChIP-Seq_U87_Human1.27317286
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.26188607
78EWS_26573619_Chip-Seq_HEK293_Human1.24805351
79STAT3_23295773_ChIP-Seq_U87_Human1.24154766
80PKCTHETA_26484144_Chip-Seq_BREAST_Human1.23861449
81SOX9_26525672_Chip-Seq_HEART_Mouse1.22486772
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20637662
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20356174
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20122144
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.19516659
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18500609
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18073823
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15671626
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15660727
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.15480081
91GATA1_26923725_Chip-Seq_HPCs_Mouse1.14532054
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14432197
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14238624
94XRN2_22483619_ChIP-Seq_HELA_Human1.13593087
95NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12973886
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11479421
97* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10022130
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09559655
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09515423
100NANOG_21062744_ChIP-ChIP_HESCs_Human1.09171700
101CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08585817
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07909364
103* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06992244
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06801720
105MYC_22102868_ChIP-Seq_BL_Human1.06332705
106MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06013207
107AR_25329375_ChIP-Seq_VCAP_Human1.05109137
108* AR_19668381_ChIP-Seq_PC3_Human1.05071016
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04071127
110JUN_21703547_ChIP-Seq_K562_Human1.03751104
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03088911
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02378410
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01892776
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01265553
115SOX2_16153702_ChIP-ChIP_HESCs_Human1.01071806
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99309494
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98965869
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.98798098
119RUNX2_22187159_ChIP-Seq_PCA_Human0.98438672
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97469805
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97303625
122* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95960224
123AR_21572438_ChIP-Seq_LNCaP_Human0.95877361
124FLI1_27457419_Chip-Seq_LIVER_Mouse0.95421942
125RING1B_27294783_Chip-Seq_ESCs_Mouse0.94411309
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93856449
127P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93810611
128THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93769336
129ER_23166858_ChIP-Seq_MCF-7_Human0.93625046
130ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92897772
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92304741
132SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89454496
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89377344
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89377344
135ZNF274_21170338_ChIP-Seq_K562_Hela0.89107227
136* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.88918102
137CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88854800
138UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88566400
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.87545392
140SALL1_21062744_ChIP-ChIP_HESCs_Human0.87297670
141KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87174607
142POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87135320
143PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86376376
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86067330
145PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85628611
146PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85358538
147PIAS1_25552417_ChIP-Seq_VCAP_Human0.84184723
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83682751
149POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83367804
150RUNX1_26923725_Chip-Seq_HPCs_Mouse0.82717301
151TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81583253
152TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81367539
153CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81030728
154SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80873279
155UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80820563
156* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80449166
157NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78521892
158* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.77630730
159TTF2_22483619_ChIP-Seq_HELA_Human0.77522676
160RING1B_27294783_Chip-Seq_NPCs_Mouse0.76531834
161KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76490813
162SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75794195
163TET1_21490601_ChIP-Seq_MESCs_Mouse0.75309383
164THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73239529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.98834557
2MP0004859_abnormal_synaptic_plasticity4.97710619
3MP0003635_abnormal_synaptic_transmissio3.74564074
4* MP0009046_muscle_twitch3.37591886
5* MP0009745_abnormal_behavioral_response3.37406387
6MP0002822_catalepsy3.17189390
7* MP0002064_seizures3.12577901
8MP0002063_abnormal_learning/memory/cond2.88225149
9MP0003787_abnormal_imprinting2.85446586
10MP0005423_abnormal_somatic_nervous2.76050960
11MP0001968_abnormal_touch/_nociception2.74273812
12MP0002572_abnormal_emotion/affect_behav2.63740090
13MP0004270_analgesia2.59034484
14MP0002272_abnormal_nervous_system2.56633537
15MP0001486_abnormal_startle_reflex2.41223456
16MP0003693_abnormal_embryo_hatching2.34173347
17MP0002734_abnormal_mechanical_nocicepti2.32515233
18MP0003077_abnormal_cell_cycle2.31942291
19MP0008877_abnormal_DNA_methylation2.25770115
20MP0001501_abnormal_sleep_pattern2.24563966
21MP0003705_abnormal_hypodermis_morpholog2.19575478
22MP0003122_maternal_imprinting2.18400463
23MP0002736_abnormal_nociception_after2.13161146
24MP0004957_abnormal_blastocyst_morpholog2.12115551
25MP0001529_abnormal_vocalization2.05678880
26MP0002067_abnormal_sensory_capabilities2.01888738
27MP0005646_abnormal_pituitary_gland1.96248446
28MP0001188_hyperpigmentation1.91441142
29MP0001440_abnormal_grooming_behavior1.87016963
30MP0002733_abnormal_thermal_nociception1.84879898
31MP0001970_abnormal_pain_threshold1.82502853
32MP0002735_abnormal_chemical_nociception1.82079513
33MP0004142_abnormal_muscle_tone1.79715298
34MP0003123_paternal_imprinting1.77017316
35MP0008932_abnormal_embryonic_tissue1.76679072
36MP0003121_genomic_imprinting1.72796194
37MP0008569_lethality_at_weaning1.72695096
38MP0002557_abnormal_social/conspecific_i1.71453750
39MP0006276_abnormal_autonomic_nervous1.71139084
40MP0005386_behavior/neurological_phenoty1.68041177
41MP0004924_abnormal_behavior1.68041177
42MP0002184_abnormal_innervation1.60048181
43MP0001346_abnormal_lacrimal_gland1.56536321
44MP0009672_abnormal_birth_weight1.51150344
45MP0000569_abnormal_digit_pigmentation1.49205194
46MP0002653_abnormal_ependyma_morphology1.48447210
47MP0002877_abnormal_melanocyte_morpholog1.46803378
48MP0003879_abnormal_hair_cell1.45250685
49MP0001984_abnormal_olfaction1.41984911
50* MP0004811_abnormal_neuron_physiology1.40611854
51MP0001730_embryonic_growth_arrest1.34724798
52MP0000350_abnormal_cell_proliferation1.32538145
53MP0005076_abnormal_cell_differentiation1.32358128
54MP0000778_abnormal_nervous_system1.31480343
55MP0001299_abnormal_eye_distance/1.30896056
56* MP0002066_abnormal_motor_capabilities/c1.30591788
57MP0000955_abnormal_spinal_cord1.28986982
58MP0005645_abnormal_hypothalamus_physiol1.27210807
59MP0002882_abnormal_neuron_morphology1.25252533
60MP0000428_abnormal_craniofacial_morphol1.21926249
61MP0008007_abnormal_cellular_replicative1.18112537
62MP0001905_abnormal_dopamine_level1.16660983
63MP0008058_abnormal_DNA_repair1.13603110
64MP0003111_abnormal_nucleus_morphology1.12754718
65MP0000537_abnormal_urethra_morphology1.12605983
66* MP0002152_abnormal_brain_morphology1.11476203
67MP0005394_taste/olfaction_phenotype1.10747708
68MP0005499_abnormal_olfactory_system1.10747708
69MP0010030_abnormal_orbit_morphology1.09886702
70MP0002085_abnormal_embryonic_tissue1.07366826
71MP0001697_abnormal_embryo_size1.06761435
72MP0008872_abnormal_physiological_respon1.06754436
73MP0001348_abnormal_lacrimal_gland1.06385989
74MP0005257_abnormal_intraocular_pressure1.04792303
75MP0005380_embryogenesis_phenotype1.04729054
76MP0001672_abnormal_embryogenesis/_devel1.04729054
77MP0002084_abnormal_developmental_patter1.03680664
78MP0000566_synostosis1.02721102
79MP0010352_gastrointestinal_tract_polyps1.01363462
80MP0002080_prenatal_lethality1.01287372
81MP0004233_abnormal_muscle_weight1.00704058
82MP0003890_abnormal_embryonic-extraembry1.00215158
83MP0009780_abnormal_chondrocyte_physiolo0.99918079
84MP0003385_abnormal_body_wall0.99836897
85MP0003631_nervous_system_phenotype0.99173539
86MP0004147_increased_porphyrin_level0.99157523
87MP0008057_abnormal_DNA_replication0.96785769
88MP0010094_abnormal_chromosome_stability0.96194402
89MP0003633_abnormal_nervous_system0.96181261
90MP0005409_darkened_coat_color0.95629292
91MP0004885_abnormal_endolymph0.95403435
92MP0000579_abnormal_nail_morphology0.92379626
93MP0002697_abnormal_eye_size0.92041156
94MP0000631_abnormal_neuroendocrine_gland0.91095253
95MP0010307_abnormal_tumor_latency0.91021484
96MP0003937_abnormal_limbs/digits/tail_de0.89578873
97MP0001963_abnormal_hearing_physiology0.88574758
98MP0003634_abnormal_glial_cell0.88490016
99MP0003632_abnormal_nervous_system0.86451738
100MP0002081_perinatal_lethality0.85782211
101MP0001849_ear_inflammation0.85617827
102MP0002249_abnormal_larynx_morphology0.84957270
103MP0002229_neurodegeneration0.84829790
104MP0003984_embryonic_growth_retardation0.83433582
105MP0005623_abnormal_meninges_morphology0.82049628
106MP0001485_abnormal_pinna_reflex0.81167667
107MP0002909_abnormal_adrenal_gland0.80842937
108MP0009703_decreased_birth_body0.78719844
109MP0003329_amyloid_beta_deposits0.78499882
110MP0001502_abnormal_circadian_rhythm0.78433535
111MP0002088_abnormal_embryonic_growth/wei0.77551560
112MP0002089_abnormal_postnatal_growth/wei0.77539245
113MP0000015_abnormal_ear_pigmentation0.77438138
114MP0004197_abnormal_fetal_growth/weight/0.77398279
115MP0009697_abnormal_copulation0.76996399
116MP0002234_abnormal_pharynx_morphology0.76523663
117MP0002752_abnormal_somatic_nervous0.76519712
118MP0005171_absent_coat_pigmentation0.74848204
119MP0000920_abnormal_myelination0.74298026
120MP0001293_anophthalmia0.74105241
121MP0003861_abnormal_nervous_system0.74061794
122MP0008874_decreased_physiological_sensi0.73041241
123MP0001986_abnormal_taste_sensitivity0.72767623
124* MP0003698_abnormal_male_reproductive0.72266308
125MP0002069_abnormal_eating/drinking_beha0.71805587
126MP0003938_abnormal_ear_development0.70902746
127MP0006292_abnormal_olfactory_placode0.70607727
128MP0003941_abnormal_skin_development0.69619466
129* MP0010770_preweaning_lethality0.69072224
130* MP0002082_postnatal_lethality0.69072224
131MP0010769_abnormal_survival0.68812265
132MP0004742_abnormal_vestibular_system0.68427485
133MP0002102_abnormal_ear_morphology0.68421938
134MP0010768_mortality/aging0.68053706
135MP0001177_atelectasis0.67221187
136MP0004085_abnormal_heartbeat0.66823712
137MP0001943_abnormal_respiration0.66554905
138MP0003136_yellow_coat_color0.65744439
139MP0004858_abnormal_nervous_system0.60947251
140MP0004145_abnormal_muscle_electrophysio0.60793784
141MP0005551_abnormal_eye_electrophysiolog0.59815365
142MP0000026_abnormal_inner_ear0.59604520
143MP0005410_abnormal_fertilization0.56440200
144MP0002751_abnormal_autonomic_nervous0.55860363
145MP0002638_abnormal_pupillary_reflex0.53588242
146MP0000751_myopathy0.51223302
147MP0008260_abnormal_autophagy0.50731179
148MP0003786_premature_aging0.50219042

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.57109214
2Febrile seizures (HP:0002373)5.43370865
3Atonic seizures (HP:0010819)5.36905468
4Focal seizures (HP:0007359)5.33699569
5Epileptic encephalopathy (HP:0200134)5.00829627
6Myokymia (HP:0002411)4.73680464
7Absence seizures (HP:0002121)3.93821434
8Generalized tonic-clonic seizures (HP:0002069)3.69056070
9Dialeptic seizures (HP:0011146)3.63998096
10Progressive cerebellar ataxia (HP:0002073)3.54954347
11Visual hallucinations (HP:0002367)3.41561475
12Increased nuchal translucency (HP:0010880)3.35813990
13Broad-based gait (HP:0002136)3.35469905
14Hyperventilation (HP:0002883)3.31407682
15Gaze-evoked nystagmus (HP:0000640)3.23560706
16Abnormality of the labia minora (HP:0012880)3.23495482
17Abnormal hair whorl (HP:0010721)2.99483540
18Urinary bladder sphincter dysfunction (HP:0002839)2.83366012
19Hyperacusis (HP:0010780)2.74173742
20Dysdiadochokinesis (HP:0002075)2.73018813
21Impaired vibration sensation in the lower limbs (HP:0002166)2.69816691
22Hemiparesis (HP:0001269)2.59127737
23Poor eye contact (HP:0000817)2.53794593
24Impaired smooth pursuit (HP:0007772)2.47966789
25Cerebral hypomyelination (HP:0006808)2.42855432
26Depression (HP:0000716)2.42000125
27Abnormal social behavior (HP:0012433)2.41412618
28Impaired social interactions (HP:0000735)2.41412618
29Diplopia (HP:0000651)2.39512749
30Abnormality of binocular vision (HP:0011514)2.39512749
31Progressive inability to walk (HP:0002505)2.37805620
32Protruding tongue (HP:0010808)2.36505295
33Truncal ataxia (HP:0002078)2.36313484
34Abnormality of cochlea (HP:0000375)2.36189568
35Abnormal eating behavior (HP:0100738)2.32100313
36Morphological abnormality of the inner ear (HP:0011390)2.31674795
37Obstructive sleep apnea (HP:0002870)2.31284695
38Excessive salivation (HP:0003781)2.29610505
39Drooling (HP:0002307)2.29610505
40Absent speech (HP:0001344)2.27233705
41Papilledema (HP:0001085)2.26466491
42Abnormality of ocular smooth pursuit (HP:0000617)2.25294440
43Resting tremor (HP:0002322)2.25112771
44Cortical dysplasia (HP:0002539)2.23302138
45Ankle clonus (HP:0011448)2.23184468
46Anxiety (HP:0000739)2.22562204
47Status epilepticus (HP:0002133)2.18993437
48Urethral obstruction (HP:0000796)2.17548841
49Genetic anticipation (HP:0003743)2.16890974
50Overriding aorta (HP:0002623)2.16216096
51Dysmetric saccades (HP:0000641)2.15532473
52Postural instability (HP:0002172)2.14301745
53Dysmetria (HP:0001310)2.13851952
54Hemiplegia (HP:0002301)2.13544203
55Bradykinesia (HP:0002067)2.10884539
56Shallow orbits (HP:0000586)2.10806868
57Amblyopia (HP:0000646)2.08868606
58Hyperthyroidism (HP:0000836)2.08778989
59Absent/shortened dynein arms (HP:0200106)2.08473469
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.08473469
61Heterotopia (HP:0002282)2.06206348
62Birth length less than 3rd percentile (HP:0003561)2.05835338
63High anterior hairline (HP:0009890)2.04505654
64Failure to thrive in infancy (HP:0001531)2.01861561
65Impaired vibratory sensation (HP:0002495)2.01389574
66Gait imbalance (HP:0002141)2.00545003
67Ankyloglossia (HP:0010296)2.00158748
68Abnormality of the corticospinal tract (HP:0002492)2.00141717
69Action tremor (HP:0002345)1.98990880
70Fetal akinesia sequence (HP:0001989)1.97124692
71Epileptiform EEG discharges (HP:0011182)1.96670166
72Insidious onset (HP:0003587)1.96139120
73Termporal pattern (HP:0011008)1.96139120
74Polyphagia (HP:0002591)1.96093473
75Spastic gait (HP:0002064)1.95369454
76Meckel diverticulum (HP:0002245)1.94589503
77Generalized hypotonia (HP:0001290)1.93927750
78Obsessive-compulsive behavior (HP:0000722)1.93923939
79Elfin facies (HP:0004428)1.92264831
80Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92059275
81Peripheral hypomyelination (HP:0007182)1.90494453
82Abnormality of the lower motor neuron (HP:0002366)1.88884973
83Inability to walk (HP:0002540)1.88222498
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87818953
85Degeneration of the lateral corticospinal tracts (HP:0002314)1.87818953
86EEG with generalized epileptiform discharges (HP:0011198)1.86890836
87Cafe-au-lait spot (HP:0000957)1.86410879
88Volvulus (HP:0002580)1.85965806
89Abnormality of the carotid arteries (HP:0005344)1.85615657
90Specific learning disability (HP:0001328)1.84575015
91Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84547746
92Insomnia (HP:0100785)1.84342219
93Congenital primary aphakia (HP:0007707)1.84019323
94Duplication of thumb phalanx (HP:0009942)1.83569911
95Abnormality of the ileum (HP:0001549)1.83562702
96Tetraplegia (HP:0002445)1.82091024
97Relative macrocephaly (HP:0004482)1.81555095
98Sleep apnea (HP:0010535)1.81313255
99Pointed chin (HP:0000307)1.80776475
100Abnormality of chromosome stability (HP:0003220)1.80444820
101Urinary urgency (HP:0000012)1.80417563
102Supranuclear gaze palsy (HP:0000605)1.80405771
103Ectopic kidney (HP:0000086)1.80180092
104Missing ribs (HP:0000921)1.80133892
105Chromsome breakage (HP:0040012)1.79839790
106Limb dystonia (HP:0002451)1.79728529
107Medial flaring of the eyebrow (HP:0010747)1.77956468
108Renal duplication (HP:0000075)1.77753779
109Renovascular hypertension (HP:0100817)1.77205427
110Scanning speech (HP:0002168)1.77065081
111Stereotypic behavior (HP:0000733)1.76719489
112Hypsarrhythmia (HP:0002521)1.75866636
113Annular pancreas (HP:0001734)1.75411158
114Broad distal phalanx of finger (HP:0009836)1.74905085
115Vertebral arch anomaly (HP:0008438)1.74788640
116Absent radius (HP:0003974)1.74278787
117Narrow nasal bridge (HP:0000446)1.74161033
118Attention deficit hyperactivity disorder (HP:0007018)1.73504277
119Aplasia/Hypoplasia of the uvula (HP:0010293)1.73092336
120Nephroblastoma (Wilms tumor) (HP:0002667)1.72605872
121Hypopigmentation of the fundus (HP:0007894)1.72235152
122Bronchomalacia (HP:0002780)1.71109575
123Sensory axonal neuropathy (HP:0003390)1.69998553
124Overlapping toe (HP:0001845)1.69941677
125Abnormal lung lobation (HP:0002101)1.69734918
126Abnormality of chromosome segregation (HP:0002916)1.68482398
127Lower limb amyotrophy (HP:0007210)1.68425393
128Small intestinal stenosis (HP:0012848)1.68363927
129Duodenal stenosis (HP:0100867)1.68363927
130Tracheomalacia (HP:0002779)1.67991505
131Poor suck (HP:0002033)1.67727042
132Ulnar bowing (HP:0003031)1.67254602
133Generalized myoclonic seizures (HP:0002123)1.66525867
134Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.66496438
135Cerebral inclusion bodies (HP:0100314)1.66222076
136Aplasia/Hypoplasia of the sternum (HP:0006714)1.65995004
137Turricephaly (HP:0000262)1.64767967
138Nephrogenic diabetes insipidus (HP:0009806)1.64080249
139Embryonal renal neoplasm (HP:0011794)1.63326872
140Abnormality of the preputium (HP:0100587)1.61916206
141Abnormality of the heme biosynthetic pathway (HP:0010472)1.61512929
142Cholecystitis (HP:0001082)1.61053494
143Abnormal gallbladder physiology (HP:0012438)1.61053494
144Trigonocephaly (HP:0000243)1.60483107
145Aplasia involving forearm bones (HP:0009822)1.59830779
146Absent forearm bone (HP:0003953)1.59830779
147Abnormal respiratory epithelium morphology (HP:0012253)1.59755487
148Abnormal respiratory motile cilium morphology (HP:0005938)1.59755487
149Aplasia involving bones of the upper limbs (HP:0009823)1.59506683
150Aplasia of the phalanges of the hand (HP:0009802)1.59506683
151Aplasia involving bones of the extremities (HP:0009825)1.59506683
152Abnormal ciliary motility (HP:0012262)1.59313800
153Incomplete penetrance (HP:0003829)1.58938600
154Gastroesophageal reflux (HP:0002020)1.58234028
155Blue irides (HP:0000635)1.57998170
156Impulsivity (HP:0100710)1.56863943
157Mild short stature (HP:0003502)1.56398919
158Abnormality of salivation (HP:0100755)1.55992549
159Bowel incontinence (HP:0002607)1.55779883
160Psychosis (HP:0000709)1.54868654
161Autism (HP:0000717)1.54749229
162Deep palmar crease (HP:0006191)1.54686579
163Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.53674098
164Neuroblastoma (HP:0003006)1.53674098
165Primitive neuroectodermal tumor (HP:0030065)1.53674098
166Neuroblastic tumors (HP:0004376)1.53674098
167Abnormality of the astrocytes (HP:0100707)1.53617930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.34834234
2NTRK33.70353279
3EPHA43.12424249
4MAP3K43.10381195
5MAP3K92.96573007
6MAP2K72.94929589
7MAP3K122.71689926
8CDK122.68989401
9TNIK2.46614066
10PNCK2.42157227
11NTRK22.16704398
12MINK12.00615913
13AKT31.89608672
14ICK1.84808115
15DAPK21.84243911
16DAPK11.79625402
17CCNB11.76667037
18PLK21.72190301
19RIPK41.70761006
20CDC71.60227783
21MKNK21.56914327
22MAP2K41.55477646
23UHMK11.53450857
24SMG11.52812402
25EEF2K1.52506922
26SIK21.50226972
27PBK1.46859667
28PLK41.42034645
29TSSK61.41855278
30MARK11.39993276
31TRIB31.32663525
32FES1.31998530
33SGK21.31329962
34MAPK131.30468218
35BRSK11.27534721
36NEK11.27229346
37PRKCG1.24087358
38BUB11.23469210
39NTRK11.22469157
40CDK191.19581911
41PRPF4B1.14569190
42CDK51.14258680
43STK381.13514912
44PAK61.12833647
45MAP3K101.11609208
46GRK51.10381952
47BRD41.07888305
48BRAF1.06583624
49CAMK1D1.05074941
50PDGFRA1.04258731
51AURKB1.03374086
52SGK31.00132418
53SGK2230.99001917
54SGK4940.99001917
55EIF2AK10.96793335
56CDK180.93731589
57TNK20.93194328
58MKNK10.92729667
59PLK30.91592397
60CDK150.90165825
61CAMKK10.87322175
62CDK70.81681862
63ATR0.81424624
64WEE10.79859727
65CDK140.79772890
66SGK10.79222600
67MET0.79107346
68CDK11A0.78888027
69PRKD30.76619168
70MTOR0.75808647
71MST1R0.74988543
72LATS20.73978629
73MAP3K80.73388707
74LATS10.72871410
75CAMK2A0.72767010
76STK110.68783533
77BMPR20.68631571
78TTK0.66511405
79BRSK20.66215122
80PLK10.65770184
81NEK20.64404235
82NEK60.64291115
83KSR10.63921775
84TAF10.63214902
85ALK0.62815457
86PTK20.62645873
87OXSR10.62084705
88MELK0.61857797
89TAOK10.61563254
90CDK80.61451942
91CAMK10.58949338
92SRPK10.58710435
93CDC42BPA0.58010722
94ATM0.57651326
95SIK30.57476221
96MUSK0.55867360
97RIPK10.55005446
98MAPK100.54897315
99SCYL20.53261630
100CAMK2B0.53174794
101WNK10.52834945
102AURKA0.51484857
103* RPS6KA30.50574780
104TYRO30.48779465
105PAK20.48592830
106MAP3K60.48313082
107CAMKK20.47900331
108ERBB40.47272931
109ARAF0.46884986
110PRKDC0.46453336
111CHEK20.46071566
112PDK40.46061267
113PDK30.46061267
114CDK10.45859573
115RAF10.45590145
116BMX0.45120202
117CAMK40.44791956
118CHEK10.44706283
119RPS6KB20.44484576
120DYRK1A0.44426041
121MARK20.43310641
122WNK30.42791677
123NME10.42769517
124KSR20.41337620
125PRKCB0.41311710
126GSK3B0.40387105
127CDK30.40317307
128CSNK1E0.38579209
129YES10.38352500
130PRKCE0.37713127
131ADRBK20.37547696
132CDK20.37321516
133CAMK1G0.37083843
134PRKCH0.37010240

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.39913536
2Synaptic vesicle cycle_Homo sapiens_hsa047213.82488658
3GABAergic synapse_Homo sapiens_hsa047272.79141521
4Olfactory transduction_Homo sapiens_hsa047402.74749768
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70679573
6Morphine addiction_Homo sapiens_hsa050322.61953049
7Long-term potentiation_Homo sapiens_hsa047202.47453813
8Collecting duct acid secretion_Homo sapiens_hsa049662.43434348
9Glutamatergic synapse_Homo sapiens_hsa047242.31972869
10Circadian entrainment_Homo sapiens_hsa047132.31725336
11Amphetamine addiction_Homo sapiens_hsa050312.25007141
12Dopaminergic synapse_Homo sapiens_hsa047281.99196531
13Taste transduction_Homo sapiens_hsa047421.98555490
14Salivary secretion_Homo sapiens_hsa049701.89783848
15Long-term depression_Homo sapiens_hsa047301.74609100
16Oocyte meiosis_Homo sapiens_hsa041141.67206945
17Serotonergic synapse_Homo sapiens_hsa047261.67137309
18Insulin secretion_Homo sapiens_hsa049111.62402154
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58842526
20Gastric acid secretion_Homo sapiens_hsa049711.56283033
21Cholinergic synapse_Homo sapiens_hsa047251.54861190
22Calcium signaling pathway_Homo sapiens_hsa040201.54591745
23Cocaine addiction_Homo sapiens_hsa050301.45271651
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41003118
25Renin secretion_Homo sapiens_hsa049241.39759514
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36952770
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34025763
28Oxidative phosphorylation_Homo sapiens_hsa001901.33406597
29Oxytocin signaling pathway_Homo sapiens_hsa049211.33048739
30Base excision repair_Homo sapiens_hsa034101.33032010
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32620766
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27094873
33Vibrio cholerae infection_Homo sapiens_hsa051101.26319363
34Gap junction_Homo sapiens_hsa045401.22288536
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20020071
36GnRH signaling pathway_Homo sapiens_hsa049121.14729001
37Biosynthesis of amino acids_Homo sapiens_hsa012301.14351312
38Cardiac muscle contraction_Homo sapiens_hsa042601.13274838
39Adherens junction_Homo sapiens_hsa045201.12775341
40Alcoholism_Homo sapiens_hsa050341.12312539
41Lysine degradation_Homo sapiens_hsa003101.10562793
42MicroRNAs in cancer_Homo sapiens_hsa052061.10193164
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08133571
44Hippo signaling pathway_Homo sapiens_hsa043901.07791083
45Thyroid cancer_Homo sapiens_hsa052161.07249652
46Spliceosome_Homo sapiens_hsa030401.07233089
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06711722
48cAMP signaling pathway_Homo sapiens_hsa040241.06400488
49Nucleotide excision repair_Homo sapiens_hsa034201.03568358
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.03516606
51Parkinsons disease_Homo sapiens_hsa050121.03009111
52Estrogen signaling pathway_Homo sapiens_hsa049151.01191394
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99725262
54Glioma_Homo sapiens_hsa052140.99175552
55Huntingtons disease_Homo sapiens_hsa050160.99141585
56Chronic myeloid leukemia_Homo sapiens_hsa052200.95480598
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93306180
58Melanogenesis_Homo sapiens_hsa049160.93143122
59Phototransduction_Homo sapiens_hsa047440.90097909
60Alzheimers disease_Homo sapiens_hsa050100.88614058
61ErbB signaling pathway_Homo sapiens_hsa040120.87615803
62Type I diabetes mellitus_Homo sapiens_hsa049400.86639133
63One carbon pool by folate_Homo sapiens_hsa006700.84804862
64Endometrial cancer_Homo sapiens_hsa052130.83947620
65Fanconi anemia pathway_Homo sapiens_hsa034600.81139563
66Type II diabetes mellitus_Homo sapiens_hsa049300.79113346
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77208277
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.74065125
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73429037
70Dorso-ventral axis formation_Homo sapiens_hsa043200.72413250
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71551980
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69905683
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68660333
74Axon guidance_Homo sapiens_hsa043600.68557515
75Basal cell carcinoma_Homo sapiens_hsa052170.66450142
76mRNA surveillance pathway_Homo sapiens_hsa030150.66137036
77Cell cycle_Homo sapiens_hsa041100.65748932
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65545287
79Vitamin B6 metabolism_Homo sapiens_hsa007500.64086780
80Tight junction_Homo sapiens_hsa045300.63820896
81Prion diseases_Homo sapiens_hsa050200.63086646
82MAPK signaling pathway_Homo sapiens_hsa040100.62836573
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61276160
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58483375
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.57980823
86Renal cell carcinoma_Homo sapiens_hsa052110.57903183
87Proteoglycans in cancer_Homo sapiens_hsa052050.57629530
88Inositol phosphate metabolism_Homo sapiens_hsa005620.54473428
89Wnt signaling pathway_Homo sapiens_hsa043100.54400784
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54346957
91VEGF signaling pathway_Homo sapiens_hsa043700.53955467
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53580478
93Homologous recombination_Homo sapiens_hsa034400.53359923
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53206571
95Pancreatic cancer_Homo sapiens_hsa052120.51146278
96Prostate cancer_Homo sapiens_hsa052150.50798205
97Carbon metabolism_Homo sapiens_hsa012000.49162667
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48759880
99Dilated cardiomyopathy_Homo sapiens_hsa054140.48004506
100Insulin signaling pathway_Homo sapiens_hsa049100.47780748
101Pancreatic secretion_Homo sapiens_hsa049720.47633187
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47622677
103Pentose phosphate pathway_Homo sapiens_hsa000300.47476803
104Choline metabolism in cancer_Homo sapiens_hsa052310.47464325
105Viral carcinogenesis_Homo sapiens_hsa052030.46195766
106Glucagon signaling pathway_Homo sapiens_hsa049220.43915367
107Mismatch repair_Homo sapiens_hsa034300.43901312
108Ovarian steroidogenesis_Homo sapiens_hsa049130.43643827
109Ras signaling pathway_Homo sapiens_hsa040140.43309966
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42988899
111Thyroid hormone synthesis_Homo sapiens_hsa049180.42812205
112Circadian rhythm_Homo sapiens_hsa047100.42262388
113RNA transport_Homo sapiens_hsa030130.42132357
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41439668
115Rap1 signaling pathway_Homo sapiens_hsa040150.41273766
116Rheumatoid arthritis_Homo sapiens_hsa053230.40879832
117Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40162609
118Melanoma_Homo sapiens_hsa052180.40076215
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39557771
120Basal transcription factors_Homo sapiens_hsa030220.39249392
121Non-small cell lung cancer_Homo sapiens_hsa052230.37974597
122Hedgehog signaling pathway_Homo sapiens_hsa043400.37162606
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.35875872
124mTOR signaling pathway_Homo sapiens_hsa041500.35389769
125RNA degradation_Homo sapiens_hsa030180.30843688
126DNA replication_Homo sapiens_hsa030300.28622390
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27790075
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27635286
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26772109
130Colorectal cancer_Homo sapiens_hsa052100.26706856
131Non-homologous end-joining_Homo sapiens_hsa034500.25613886

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