CITED1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of male gonad development (GO:2000020)8.23265191
2* melanin biosynthetic process (GO:0042438)7.48374996
3regulation of gonadotropin secretion (GO:0032276)7.45129446
4negative regulation of macrophage differentiation (GO:0045650)6.90227189
5cellular response to follicle-stimulating hormone stimulus (GO:0071372)6.89459906
6purine nucleobase biosynthetic process (GO:0009113)6.71009756
7* melanin metabolic process (GO:0006582)6.58798932
8regulation of male gonad development (GO:2000018)6.55854968
9* secondary metabolite biosynthetic process (GO:0044550)6.44620988
10nucleobase biosynthetic process (GO:0046112)5.99018134
11gonadal mesoderm development (GO:0007506)5.92203052
12ribosome assembly (GO:0042255)5.57953824
13cellular response to gonadotropin stimulus (GO:0071371)5.41613496
14response to follicle-stimulating hormone (GO:0032354)5.29732399
15fusion of sperm to egg plasma membrane (GO:0007342)5.23473026
16mitotic metaphase plate congression (GO:0007080)5.09324622
17sex differentiation (GO:0007548)5.07458246
18hemoglobin metabolic process (GO:0020027)4.91796027
19nephron tubule formation (GO:0072079)4.82349356
20ribosome biogenesis (GO:0042254)4.79615000
21regulation of G0 to G1 transition (GO:0070316)4.75620411
22sex determination (GO:0007530)4.73932141
23cornea development in camera-type eye (GO:0061303)4.62996169
24anatomical structure regression (GO:0060033)4.60672446
25vitamin transmembrane transport (GO:0035461)4.54365308
26transcription elongation from RNA polymerase III promoter (GO:0006385)4.52454330
27termination of RNA polymerase III transcription (GO:0006386)4.52454330
28formation of translation preinitiation complex (GO:0001731)4.52429119
29seminiferous tubule development (GO:0072520)4.45844471
30regulation of spindle organization (GO:0090224)4.43453753
31short-term memory (GO:0007614)4.38546175
32transcription elongation from RNA polymerase I promoter (GO:0006362)4.34428420
33termination of RNA polymerase I transcription (GO:0006363)4.32661202
34folic acid metabolic process (GO:0046655)4.32192499
35response to gonadotropin (GO:0034698)4.29251925
36DNA replication checkpoint (GO:0000076)4.22819702
37maturation of SSU-rRNA (GO:0030490)4.21676206
38skeletal muscle organ development (GO:0060538)4.21460063
39regulation of female gonad development (GO:2000194)4.20163452
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.20002595
41short-chain fatty acid metabolic process (GO:0046459)4.19843802
42transcription from RNA polymerase I promoter (GO:0006360)4.16051708
437-methylguanosine mRNA capping (GO:0006370)4.12400589
44proteasome assembly (GO:0043248)4.09341521
45plasma membrane fusion (GO:0045026)4.07528306
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.05763826
47folic acid transport (GO:0015884)4.04947454
48male sex determination (GO:0030238)4.04937469
49ribonucleoprotein complex biogenesis (GO:0022613)3.98400649
50rRNA modification (GO:0000154)3.96323281
517-methylguanosine RNA capping (GO:0009452)3.95897034
52RNA capping (GO:0036260)3.95897034
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.92825322
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.92159457
55lung-associated mesenchyme development (GO:0060484)3.90632745
56GMP metabolic process (GO:0046037)3.89943715
57transcription initiation from RNA polymerase I promoter (GO:0006361)3.86475058
58metaphase plate congression (GO:0051310)3.85080135
59endocardial cushion development (GO:0003197)3.84054984
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.75670681
61ribosomal large subunit biogenesis (GO:0042273)3.72171257
62guanosine-containing compound biosynthetic process (GO:1901070)3.70864159
63regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.69836683
64diaphragm development (GO:0060539)3.67970967
65oocyte maturation (GO:0001556)3.64533877
66positive regulation of chromosome segregation (GO:0051984)3.63956954
67positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.61122807
68blastocyst development (GO:0001824)3.60100727
69rRNA processing (GO:0006364)3.53444696
70acrosome reaction (GO:0007340)3.48865170
71spliceosomal snRNP assembly (GO:0000387)3.48788381
72muscle cell fate commitment (GO:0042693)3.47037455
73male genitalia development (GO:0030539)3.46269364
74regulation of mitotic spindle organization (GO:0060236)3.45771740
75protein localization to kinetochore (GO:0034501)3.45416284
76rRNA metabolic process (GO:0016072)3.43509332
77spindle checkpoint (GO:0031577)3.42849161
78negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.42336226
79regulation of translation in response to stress (GO:0043555)3.41186496
80mitotic spindle checkpoint (GO:0071174)3.39610512
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.38331087
82negative regulation of ligase activity (GO:0051352)3.35849083
83negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.35849083
84positive regulation of ligase activity (GO:0051351)3.32910643
85establishment of protein localization to mitochondrial membrane (GO:0090151)3.31956824
86cardiac right ventricle morphogenesis (GO:0003215)3.30803859
87positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.28057105
88ventricular cardiac muscle cell development (GO:0055015)3.26629602
89positive regulation of viral transcription (GO:0050434)3.24767597
90negative regulation of chromosome segregation (GO:0051985)3.24711390
91mitotic spindle assembly checkpoint (GO:0007094)3.24635661
92protein localization to synapse (GO:0035418)3.24438169
93DNA-templated transcription, elongation (GO:0006354)3.22719800
94regulation of ubiquitin-protein transferase activity (GO:0051438)3.21926531
95negative regulation of mitotic sister chromatid separation (GO:2000816)3.21083085
96negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21083085
97negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21083085
98negative regulation of sister chromatid segregation (GO:0033046)3.21083085
99positive regulation of odontogenesis (GO:0042482)3.20284719
100L-methionine salvage (GO:0071267)3.18614710
101L-methionine biosynthetic process (GO:0071265)3.18614710
102amino acid salvage (GO:0043102)3.18614710
103regulation of chromosome segregation (GO:0051983)3.17023421
104transcription elongation from RNA polymerase II promoter (GO:0006368)3.16894820
105regulation of cardiac muscle cell contraction (GO:0086004)3.16035894
106spindle assembly checkpoint (GO:0071173)3.15246799
107reproductive system development (GO:0061458)3.14949378
108mitotic nuclear envelope disassembly (GO:0007077)3.14824813
109DNA replication-dependent nucleosome assembly (GO:0006335)3.11963569
110DNA replication-dependent nucleosome organization (GO:0034723)3.11963569
111negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.10551077
112mitotic sister chromatid segregation (GO:0000070)3.08971390
113intestinal epithelial cell development (GO:0060576)3.08532806
114male gonad development (GO:0008584)3.08469264
115lipopolysaccharide biosynthetic process (GO:0009103)3.07286421
116attachment of spindle microtubules to kinetochore (GO:0008608)3.07105377
117cellular component biogenesis (GO:0044085)3.03187972
118regulation of double-strand break repair via homologous recombination (GO:0010569)3.02986439
119regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02916634
120negative regulation of receptor-mediated endocytosis (GO:0048261)3.02852884
121intraciliary transport (GO:0042073)3.02736603
122NADH metabolic process (GO:0006734)3.02022118
123maturation of 5.8S rRNA (GO:0000460)3.01839010
124regulation of ligase activity (GO:0051340)2.99821687
125respiratory system process (GO:0003016)2.97737204
126anterior/posterior axis specification, embryo (GO:0008595)2.97714587
127mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.97252488
128histone-serine phosphorylation (GO:0035404)2.96473426
129glutathione derivative biosynthetic process (GO:1901687)2.96197134
130glutathione derivative metabolic process (GO:1901685)2.96197134
131regulation of cellular amino acid metabolic process (GO:0006521)2.96002489
132glycine metabolic process (GO:0006544)2.95993076
133pyrimidine nucleobase catabolic process (GO:0006208)2.95508533
134DNA replication-independent nucleosome organization (GO:0034724)2.95372093
135DNA replication-independent nucleosome assembly (GO:0006336)2.95372093
136regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.95191139
137regulation of nuclear cell cycle DNA replication (GO:0033262)2.95113350
138DNA deamination (GO:0045006)2.94186728
139epithelial cell fate commitment (GO:0072148)2.93920111
140transcription-coupled nucleotide-excision repair (GO:0006283)2.93014168
141rRNA methylation (GO:0031167)2.92480849
142CENP-A containing nucleosome assembly (GO:0034080)2.92263539
143negative regulation of translational initiation (GO:0045947)2.92192124
144behavioral response to nicotine (GO:0035095)2.91356896
145synaptonemal complex assembly (GO:0007130)2.90632004
146nuclear envelope disassembly (GO:0051081)2.89818097
147membrane disassembly (GO:0030397)2.89818097
148protein localization to chromosome, centromeric region (GO:0071459)2.89781814
149autophagic vacuole assembly (GO:0000045)2.88846872
150cullin deneddylation (GO:0010388)2.88603223
151* phenol-containing compound biosynthetic process (GO:0046189)2.87979195
152regulation of cardioblast differentiation (GO:0051890)2.87779731
153detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.86766879
154detection of temperature stimulus involved in sensory perception (GO:0050961)2.86766879
155ATP synthesis coupled proton transport (GO:0015986)2.82907498
156energy coupled proton transport, down electrochemical gradient (GO:0015985)2.82907498
157embryonic foregut morphogenesis (GO:0048617)2.79482792
158glomerulus development (GO:0032835)2.78755649
159cerebellar Purkinje cell layer development (GO:0021680)2.77378233
160metanephric mesenchyme development (GO:0072075)2.77359034
161negative regulation of catenin import into nucleus (GO:0035414)2.77038047
162cardiac muscle adaptation (GO:0014887)2.76929345
163cardiac muscle hypertrophy in response to stress (GO:0014898)2.76929345
164muscle hypertrophy in response to stress (GO:0003299)2.76929345
165respiratory electron transport chain (GO:0022904)2.73592002
166retinal rod cell development (GO:0046548)2.72290109
167urogenital system development (GO:0001655)2.71740143
168kidney mesenchyme development (GO:0072074)2.71328356
169regulation of mesenchymal cell apoptotic process (GO:2001053)2.70759510
170* columnar/cuboidal epithelial cell differentiation (GO:0002065)2.70071910
171cellular response to oxygen radical (GO:0071450)2.68080263
172removal of superoxide radicals (GO:0019430)2.68080263
173cellular response to superoxide (GO:0071451)2.68080263
174cellular response to BMP stimulus (GO:0071773)2.67816602
175response to BMP (GO:0071772)2.67816602
176DNA strand renaturation (GO:0000733)2.66369984
177cerebral cortex neuron differentiation (GO:0021895)2.65018274
178electron transport chain (GO:0022900)2.63341747
179gonad development (GO:0008406)2.62328404
180exploration behavior (GO:0035640)2.60037388
181oxygen transport (GO:0015671)2.57760976
182layer formation in cerebral cortex (GO:0021819)2.57377475
183regulation of dopamine metabolic process (GO:0042053)2.56909158
184regulation of catecholamine metabolic process (GO:0042069)2.56909158
185protein deneddylation (GO:0000338)2.56315320
186androgen biosynthetic process (GO:0006702)2.54407547
187base-excision repair, AP site formation (GO:0006285)2.54066442
188postsynaptic membrane organization (GO:0001941)2.51296359
189melanosome organization (GO:0032438)2.50540965
190outflow tract septum morphogenesis (GO:0003148)2.49245388
191photoreceptor cell differentiation (GO:0046530)2.49080155
192eye photoreceptor cell differentiation (GO:0001754)2.49080155
193* negative regulation of metanephros development (GO:0072217)2.48520326
194Leydig cell differentiation (GO:0033327)2.48423945
195atrial septum morphogenesis (GO:0060413)2.47780343
196piRNA metabolic process (GO:0034587)2.46537000
197positive regulation of mesonephros development (GO:0061213)2.46192109
198mesonephros development (GO:0001823)2.45899569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.72187046
2E2F7_22180533_ChIP-Seq_HELA_Human4.44932737
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.06139147
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.94232787
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.73095080
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.71023957
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.69154023
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.52336260
9EZH2_22144423_ChIP-Seq_EOC_Human3.44161290
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.31414455
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.23279833
12MYC_19079543_ChIP-ChIP_MESCs_Mouse3.23045845
13FOXM1_23109430_ChIP-Seq_U2OS_Human3.16557488
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.09608542
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.07780274
16* EZH2_27304074_Chip-Seq_ESCs_Mouse2.96937208
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93025144
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.84411670
19CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.81233626
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77970388
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.68411444
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62111515
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56888814
24CBX2_27304074_Chip-Seq_ESCs_Mouse2.50404658
25* EED_16625203_ChIP-ChIP_MESCs_Mouse2.44797696
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34926045
27XRN2_22483619_ChIP-Seq_HELA_Human2.34837653
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33054910
29AR_21909140_ChIP-Seq_LNCAP_Human2.31999035
30VDR_23849224_ChIP-Seq_CD4+_Human2.26911310
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23548178
32GABP_19822575_ChIP-Seq_HepG2_Human2.22421361
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14541702
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.13460536
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10310582
36RNF2_27304074_Chip-Seq_NSC_Mouse2.09541137
37DCP1A_22483619_ChIP-Seq_HELA_Human2.07908581
38YY1_21170310_ChIP-Seq_MESCs_Mouse2.06690030
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99780012
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97746598
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.95795579
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92292715
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90033764
44* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89631356
45* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89631356
46ZNF263_19887448_ChIP-Seq_K562_Human1.89358209
47* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86526402
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.85297487
49* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84356206
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84317111
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.81674951
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80289525
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79552418
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77891826
55TTF2_22483619_ChIP-Seq_HELA_Human1.76893121
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75116630
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.71313999
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71204966
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70696522
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69202629
61KDM5A_27292631_Chip-Seq_BREAST_Human1.69075793
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68931408
63FOXP3_21729870_ChIP-Seq_TREG_Human1.68562002
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65086284
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.64167377
66* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62911872
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61394559
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60153702
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58753801
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.57874189
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57344913
72* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.56292285
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51256879
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50592065
75* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48988998
76CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.48010563
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45698151
78GBX2_23144817_ChIP-Seq_PC3_Human1.42547043
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42036270
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40896334
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38471514
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.37561392
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.34232696
84* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34089669
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.32117580
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31021602
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.29623354
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29088590
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28898269
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28489597
91REST_19997604_ChIP-ChIP_NEURONS_Mouse1.28143527
92CIITA_25753668_ChIP-Seq_RAJI_Human1.26148866
93E2F1_21310950_ChIP-Seq_MCF-7_Human1.25706346
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23120718
95* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22637226
96ELK1_19687146_ChIP-ChIP_HELA_Human1.22602958
97NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.22396860
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22139337
99* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20341907
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19441399
101ERG_21242973_ChIP-ChIP_JURKAT_Human1.18968952
102TP53_20018659_ChIP-ChIP_R1E_Mouse1.17814649
103STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17558258
104NANOG_21062744_ChIP-ChIP_HESCs_Human1.16721828
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.16226706
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15637026
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15552567
108SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14483136
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12713622
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12402396
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.11465303
112IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11379842
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10862558
114RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10649999
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.09094270
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08472120
117KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08050987
118KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08050987
119KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08050987
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07917735
121* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07809233
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06839831
123* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06407889
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04047454
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04047454
126* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.03982071
127EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.02888422
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02150100
129PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02046350
130OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01642866
131POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00989873
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00884240
133CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00611716
134SOX17_20123909_ChIP-Seq_XEN_Mouse0.98806363
135GATA1_26923725_Chip-Seq_HPCs_Mouse0.98630910
136MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98496436
137EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98395190
138PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97582800
139MYC_18940864_ChIP-ChIP_HL60_Human0.97429176
140KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96600807
141RING1B_27294783_Chip-Seq_ESCs_Mouse0.96170717
142PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95029660
143SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93375048
144CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93338188
145POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.92958905
146REST_21632747_ChIP-Seq_MESCs_Mouse0.92894275
147CTCF_27219007_Chip-Seq_Bcells_Human0.92246571
148E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92172873
149SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.91952758
150MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90651587
151JUN_21703547_ChIP-Seq_K562_Human0.90331103
152KDM2B_26808549_Chip-Seq_K562_Human0.90133306
153NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90055015
154TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.88587598
155CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87992473
156SOX3_22085726_ChIP-Seq_NPCs_Mouse0.87850271
157ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87197203
158CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86002027
159RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84645890
160SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.83324344
161ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83296046
162TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82922685
163TFEB_21752829_ChIP-Seq_HELA_Human0.82892086
164FOXP1_21924763_ChIP-Seq_HESCs_Human0.81296189
165SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79313004
166HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77967816

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.29107884
2MP0000372_irregular_coat_pigmentation4.97746819
3MP0003111_abnormal_nucleus_morphology4.32935556
4MP0008260_abnormal_autophagy3.95622217
5MP0004957_abnormal_blastocyst_morpholog3.84958146
6MP0003122_maternal_imprinting3.49707663
7MP0003718_maternal_effect3.37155998
8MP0005171_absent_coat_pigmentation3.34674016
9MP0005377_hearing/vestibular/ear_phenot3.22584227
10MP0003878_abnormal_ear_physiology3.22584227
11MP0003077_abnormal_cell_cycle3.18920296
12MP0001661_extended_life_span3.08481295
13MP0010094_abnormal_chromosome_stability2.98707459
14MP0003136_yellow_coat_color2.97773490
15MP0003786_premature_aging2.73004381
16MP0008877_abnormal_DNA_methylation2.63444157
17MP0001730_embryonic_growth_arrest2.37361641
18MP0004084_abnormal_cardiac_muscle2.36313018
19MP0002638_abnormal_pupillary_reflex2.33923621
20MP0008058_abnormal_DNA_repair2.33469345
21MP0008932_abnormal_embryonic_tissue2.27847212
22MP0000516_abnormal_urinary_system2.26007304
23MP0005367_renal/urinary_system_phenotyp2.26007304
24MP0009384_cardiac_valve_regurgitation2.23897199
25MP0003011_delayed_dark_adaptation2.23685856
26MP0008057_abnormal_DNA_replication2.16496112
27MP0005075_abnormal_melanosome_morpholog2.15537337
28* MP0003123_paternal_imprinting2.11600412
29MP0003315_abnormal_perineum_morphology1.97700014
30MP0005380_embryogenesis_phenotype1.97289357
31MP0001672_abnormal_embryogenesis/_devel1.97289357
32MP0000639_abnormal_adrenal_gland1.95438171
33MP0003567_abnormal_fetal_cardiomyocyte1.94260227
34MP0000015_abnormal_ear_pigmentation1.91213793
35MP0002822_catalepsy1.87790494
36MP0008007_abnormal_cellular_replicative1.86947946
37* MP0003121_genomic_imprinting1.82235815
38MP0003984_embryonic_growth_retardation1.80965026
39MP0002088_abnormal_embryonic_growth/wei1.77774166
40MP0006276_abnormal_autonomic_nervous1.73218796
41MP0000750_abnormal_muscle_regeneration1.67782680
42MP0001697_abnormal_embryo_size1.63388726
43MP0005451_abnormal_body_composition1.61469301
44MP0001324_abnormal_eye_pigmentation1.60432627
45MP0004885_abnormal_endolymph1.54048537
46MP0000350_abnormal_cell_proliferation1.54012333
47MP0003221_abnormal_cardiomyocyte_apopto1.53674358
48* MP0002080_prenatal_lethality1.48885191
49MP0002210_abnormal_sex_determination1.43200267
50MP0002095_abnormal_skin_pigmentation1.42929295
51MP0003938_abnormal_ear_development1.39871705
52MP0004859_abnormal_synaptic_plasticity1.38003064
53MP0008995_early_reproductive_senescence1.37533951
54MP0001919_abnormal_reproductive_system1.36554716
55MP0005257_abnormal_intraocular_pressure1.36431453
56MP0002085_abnormal_embryonic_tissue1.36187042
57MP0003806_abnormal_nucleotide_metabolis1.34542218
58MP0003119_abnormal_digestive_system1.33746136
59MP0001188_hyperpigmentation1.31708534
60MP0005409_darkened_coat_color1.31099459
61MP0005423_abnormal_somatic_nervous1.29654992
62MP0000371_diluted_coat_color1.27336659
63* MP0002086_abnormal_extraembryonic_tissu1.26115052
64MP0002160_abnormal_reproductive_system1.26030705
65MP0003186_abnormal_redox_activity1.25889423
66MP0002084_abnormal_developmental_patter1.24228515
67MP0001542_abnormal_bone_strength1.23145934
68MP0001145_abnormal_male_reproductive1.21036333
69MP0005253_abnormal_eye_physiology1.20889581
70MP0001984_abnormal_olfaction1.18725363
71MP0009333_abnormal_splenocyte_physiolog1.18094367
72MP0009840_abnormal_foam_cell1.16838157
73MP0002272_abnormal_nervous_system1.15254007
74MP0005395_other_phenotype1.14306726
75MP0006138_congestive_heart_failure1.12776366
76MP0002653_abnormal_ependyma_morphology1.11547168
77MP0002877_abnormal_melanocyte_morpholog1.11514155
78MP0000778_abnormal_nervous_system1.10987130
79MP0002127_abnormal_cardiovascular_syste1.10798701
80MP0005330_cardiomyopathy1.10505951
81MP0002269_muscular_atrophy1.10319480
82MP0001929_abnormal_gametogenesis1.10275608
83MP0000358_abnormal_cell_content/1.06936006
84MP0000653_abnormal_sex_gland1.06791630
85MP0003941_abnormal_skin_development1.06594649
86MP0001727_abnormal_embryo_implantation1.06572980
87MP0005551_abnormal_eye_electrophysiolog1.06157321
88MP0005197_abnormal_uvea_morphology1.05876126
89MP0004264_abnormal_extraembryonic_tissu1.05129206
90MP0004036_abnormal_muscle_relaxation1.04974327
91MP0005389_reproductive_system_phenotype1.04513078
92MP0005410_abnormal_fertilization1.01429068
93MP0002075_abnormal_coat/hair_pigmentati0.99775354
94MP0002090_abnormal_vision0.98901009
95MP0000747_muscle_weakness0.97738294
96MP0000537_abnormal_urethra_morphology0.97211612
97MP0004381_abnormal_hair_follicle0.95580999
98MP0002909_abnormal_adrenal_gland0.94421645
99MP0003890_abnormal_embryonic-extraembry0.94287708
100MP0000049_abnormal_middle_ear0.94120310
101MP0000428_abnormal_craniofacial_morphol0.93110838
102MP0004133_heterotaxia0.93094275
103MP0010307_abnormal_tumor_latency0.91915146
104MP0002102_abnormal_ear_morphology0.91797788
105MP0001186_pigmentation_phenotype0.91657601
106* MP0004197_abnormal_fetal_growth/weight/0.91346512
107MP0006035_abnormal_mitochondrial_morpho0.90670304
108MP0001293_anophthalmia0.88610910
109MP0002229_neurodegeneration0.88323919
110MP0001502_abnormal_circadian_rhythm0.87399565
111MP0001756_abnormal_urination0.86345391
112MP0009046_muscle_twitch0.85546993
113MP0003635_abnormal_synaptic_transmissio0.85456218
114MP0002557_abnormal_social/conspecific_i0.85006756
115MP0001485_abnormal_pinna_reflex0.84358063
116MP0005195_abnormal_posterior_eye0.84230894
117MP0003828_pulmonary_edema0.84037339
118MP0003937_abnormal_limbs/digits/tail_de0.83820234
119MP0000534_abnormal_ureter_morphology0.83676411
120MP0002882_abnormal_neuron_morphology0.82745764
121MP0003942_abnormal_urinary_system0.82642141
122MP0002752_abnormal_somatic_nervous0.82635050
123MP0000313_abnormal_cell_death0.82391102
124MP0005174_abnormal_tail_pigmentation0.82077179
125MP0005058_abnormal_lysosome_morphology0.79591721
126MP0005408_hypopigmentation0.79425289
127* MP0009672_abnormal_birth_weight0.79036155
128MP0004272_abnormal_basement_membrane0.78674178
129* MP0005384_cellular_phenotype0.78537022
130MP0002132_abnormal_respiratory_system0.78192556
131MP0002249_abnormal_larynx_morphology0.77634513
132MP0003646_muscle_fatigue0.76260297
133MP0000955_abnormal_spinal_cord0.76122819
134MP0000631_abnormal_neuroendocrine_gland0.75059512
135MP0001963_abnormal_hearing_physiology0.73859104
136MP0002938_white_spotting0.73227257
137MP0000678_abnormal_parathyroid_gland0.72756144
138MP0002063_abnormal_learning/memory/cond0.72725885
139MP0009053_abnormal_anal_canal0.72474926
140* MP0003936_abnormal_reproductive_system0.71312281
141MP0009745_abnormal_behavioral_response0.71110917
142MP0002396_abnormal_hematopoietic_system0.71016236
143MP0002067_abnormal_sensory_capabilities0.70966112
144MP0003698_abnormal_male_reproductive0.70081200
145MP0005391_vision/eye_phenotype0.69006521
146MP0003880_abnormal_central_pattern0.68963080
147MP0001970_abnormal_pain_threshold0.67502773
148MP0001119_abnormal_female_reproductive0.67316686
149MP0005621_abnormal_cell_physiology0.66935521
150MP0002161_abnormal_fertility/fecundity0.66576231
151MP0004215_abnormal_myocardial_fiber0.64966442
152MP0002064_seizures0.64200056
153MP0005646_abnormal_pituitary_gland0.63797830
154MP0002184_abnormal_innervation0.63697181
155MP0002733_abnormal_thermal_nociception0.63361890
156MP0002092_abnormal_eye_morphology0.62706370
157MP0004019_abnormal_vitamin_homeostasis0.60410451
158MP0003699_abnormal_female_reproductive0.59929962
159MP0004147_increased_porphyrin_level0.58551554
160MP0006292_abnormal_olfactory_placode0.58419325
161MP0003115_abnormal_respiratory_system0.58382355
162MP0002111_abnormal_tail_morphology0.58298464
163* MP0009703_decreased_birth_body0.58243054
164MP0001440_abnormal_grooming_behavior0.57118734
165MP0001544_abnormal_cardiovascular_syste0.57023807
166MP0005385_cardiovascular_system_phenoty0.57023807
167MP0003879_abnormal_hair_cell0.56748121

Predicted human phenotypes

RankGene SetZ-score
1Gonadal dysgenesis (HP:0000133)6.51235153
2Abnormal sex determination (HP:0012244)5.65541719
3Sex reversal (HP:0012245)5.65541719
4Testicular neoplasm (HP:0010788)5.32461298
5Male pseudohermaphroditism (HP:0000037)4.92222001
6Breast hypoplasia (HP:0003187)4.78373327
7Abnormality of the labia minora (HP:0012880)4.71866593
8Anomalous pulmonary venous return (HP:0010772)4.68693507
9Impulsivity (HP:0100710)4.68006916
10Hyperglycinemia (HP:0002154)4.56680051
11Cerebral hypomyelination (HP:0006808)4.44838529
12Birth length less than 3rd percentile (HP:0003561)4.39689950
13Abnormality of the pulmonary veins (HP:0011718)4.24450027
14Degeneration of the lateral corticospinal tracts (HP:0002314)4.00034922
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.00034922
16Multiple enchondromatosis (HP:0005701)3.90749509
17Abnormality of the umbilical cord (HP:0010881)3.85696996
18Hypoplastic heart (HP:0001961)3.80474275
19Carpal bone hypoplasia (HP:0001498)3.73670539
20Aplasia/Hypoplasia of the macula (HP:0008059)3.69110727
21Hyperglycinuria (HP:0003108)3.63070477
22Ureteral duplication (HP:0000073)3.61677266
23Congenital malformation of the right heart (HP:0011723)3.58203902
24Double outlet right ventricle (HP:0001719)3.58203902
25Abnormality of the corticospinal tract (HP:0002492)3.44289723
26Rough bone trabeculation (HP:0100670)3.43655108
27Aplasia/Hypoplasia affecting the retina (HP:0008061)3.42550296
28Patchy hypopigmentation of hair (HP:0011365)3.39458868
29White forelock (HP:0002211)3.36578682
30Patellar aplasia (HP:0006443)3.33654434
31Aplasia/Hypoplasia of the patella (HP:0006498)3.32838628
32Patent foramen ovale (HP:0001655)3.27956562
33Progressive muscle weakness (HP:0003323)3.24376377
34Abnormality of the anterior horn cell (HP:0006802)3.21423480
35Degeneration of anterior horn cells (HP:0002398)3.21423480
36Ventricular fibrillation (HP:0001663)3.21193221
37Blue irides (HP:0000635)3.17241751
38Secondary amenorrhea (HP:0000869)3.15621697
39Transposition of the great arteries (HP:0001669)3.11404687
40Abnormal connection of the cardiac segments (HP:0011545)3.11404687
41Abnormal ventriculo-arterial connection (HP:0011563)3.11404687
42Aplasia/Hypoplasia of the fovea (HP:0008060)2.96598220
43Hypoplasia of the fovea (HP:0007750)2.96598220
44Abnormality of the fovea (HP:0000493)2.95490902
45Premature ovarian failure (HP:0008209)2.94934335
46Iris hypopigmentation (HP:0007730)2.92341342
47Abnormality of male internal genitalia (HP:0000022)2.91859344
48Underdeveloped supraorbital ridges (HP:0009891)2.89096420
49Gout (HP:0001997)2.88100797
50Abnormality of glycine metabolism (HP:0010895)2.87422229
51Abnormality of serine family amino acid metabolism (HP:0010894)2.87422229
52Supernumerary spleens (HP:0009799)2.84932744
53Bundle branch block (HP:0011710)2.79860616
54Mesangial abnormality (HP:0001966)2.77837469
55Stridor (HP:0010307)2.75863229
56Beaking of vertebral bodies (HP:0004568)2.75381057
57Ocular albinism (HP:0001107)2.74498692
58Muscle fiber splitting (HP:0003555)2.71113606
59Male infertility (HP:0003251)2.67003304
60Fibular hypoplasia (HP:0003038)2.66498394
61CNS hypomyelination (HP:0003429)2.66332710
62Abnormal hemoglobin (HP:0011902)2.64918128
63Short nail (HP:0001799)2.57865011
64Skin pits (HP:0100276)2.57397249
65Female pseudohermaphroditism (HP:0010458)2.56930494
66Areflexia of lower limbs (HP:0002522)2.55569605
67Abnormality of the fetal cardiovascular system (HP:0010948)2.55278815
68Abnormal umbilical cord blood vessels (HP:0011403)2.55278815
69Single umbilical artery (HP:0001195)2.55278815
70Atrioventricular block (HP:0001678)2.54985338
71Germ cell neoplasia (HP:0100728)2.54479974
72Abnormality of the vocal cords (HP:0008777)2.53610319
73Trismus (HP:0000211)2.53308554
74Truncus arteriosus (HP:0001660)2.52932314
75Abnormal trabecular bone morphology (HP:0100671)2.51474465
76Akinesia (HP:0002304)2.49473761
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.47703909
78Infertility (HP:0000789)2.45780465
79Death in infancy (HP:0001522)2.45744412
80Abnormalities of placenta or umbilical cord (HP:0001194)2.45464501
81Aplasia/Hypoplasia involving the musculature (HP:0001460)2.45364018
82Entropion (HP:0000621)2.43312852
83Preauricular pit (HP:0004467)2.41068256
84Periauricular skin pits (HP:0100277)2.41068256
85Tongue fasciculations (HP:0001308)2.38780074
86Abnormal pancreas size (HP:0012094)2.36635804
87Selective tooth agenesis (HP:0001592)2.35650671
88Abnormality of the aortic arch (HP:0012303)2.35589775
89Absent radius (HP:0003974)2.34666613
90Retinal dysplasia (HP:0007973)2.33835082
91True hermaphroditism (HP:0010459)2.33736869
92Abnormality of serum amino acid levels (HP:0003112)2.30608561
93Hypoplasia of the capital femoral epiphysis (HP:0003090)2.29531503
94Oligomenorrhea (HP:0000876)2.28922408
95Tetraplegia (HP:0002445)2.28696669
96Ankle clonus (HP:0011448)2.26874387
97Hypopigmentation of the fundus (HP:0007894)2.26802762
98Megaloblastic anemia (HP:0001889)2.25782365
99Oligodactyly (HP:0012165)2.23800911
100Testicular atrophy (HP:0000029)2.22724449
101Abnormality of the lower motor neuron (HP:0002366)2.20599348
102Broad distal phalanx of finger (HP:0009836)2.19585721
103Delusions (HP:0000746)2.18901907
104Hand muscle atrophy (HP:0009130)2.17673493
105Premature rupture of membranes (HP:0001788)2.17668989
106Aplasia involving forearm bones (HP:0009822)2.16270821
107Absent forearm bone (HP:0003953)2.16270821
108Sparse eyelashes (HP:0000653)2.15317194
109Microretrognathia (HP:0000308)2.14612554
110Oral leukoplakia (HP:0002745)2.13713869
111Postnatal microcephaly (HP:0005484)2.09790696
112Abnormal lung lobation (HP:0002101)2.09556375
113Oligodactyly (hands) (HP:0001180)2.08604221
114Abnormality of the distal phalanges of the toes (HP:0010182)2.07680419
115Restlessness (HP:0000711)2.06153138
116Atrophy/Degeneration involving motor neurons (HP:0007373)2.05326888
117Atresia of the external auditory canal (HP:0000413)2.03878796
118Primary adrenal insufficiency (HP:0008207)2.02605976
119Polyphagia (HP:0002591)2.01565996
120Prolonged neonatal jaundice (HP:0006579)1.99681870
121Generalized hypopigmentation (HP:0007513)1.98924225
122Spinal muscular atrophy (HP:0007269)1.98850600
123Macrocytic anemia (HP:0001972)1.98420716
124Renal agenesis (HP:0000104)1.97528888
125Abnormality of cells of the erythroid lineage (HP:0012130)1.96299613
126Glossoptosis (HP:0000162)1.95346019
127Aplasia/Hypoplasia of the fibula (HP:0006492)1.95080962
128Hypoplastic left heart (HP:0004383)1.94810901
129Facial cleft (HP:0002006)1.94760754
130Personality changes (HP:0000751)1.94448507
131Hyperglycemia (HP:0003074)1.93765689
132Acute necrotizing encephalopathy (HP:0006965)1.93525323
133Adrenal hypoplasia (HP:0000835)1.92294780
134Cleft eyelid (HP:0000625)1.91814978
135Urinary urgency (HP:0000012)1.91014399
136Diaphragmatic weakness (HP:0009113)1.90479345
137Abnormal spermatogenesis (HP:0008669)1.89854745
138Papilledema (HP:0001085)1.89352203
139Calcaneovalgus deformity (HP:0001848)1.88140947
140Opisthotonus (HP:0002179)1.87888022
141Difficulty climbing stairs (HP:0003551)1.87709310
142Unsteady gait (HP:0002317)1.87539194
143Tetralogy of Fallot (HP:0001636)1.86081840
144Abnormal number of erythroid precursors (HP:0012131)1.85388946
145Acute encephalopathy (HP:0006846)1.85315884
146Muscle fibrillation (HP:0010546)1.84608005
147Aplasia/hypoplasia of the humerus (HP:0006507)1.84223261
148Horseshoe kidney (HP:0000085)1.84002845
149Meckel diverticulum (HP:0002245)1.83070908
150Deformed tarsal bones (HP:0008119)1.82977655
151Abnormal mitochondria in muscle tissue (HP:0008316)1.81211692
152Ankle contracture (HP:0006466)1.80421220
153Impaired vibration sensation in the lower limbs (HP:0002166)1.80134870
154Natal tooth (HP:0000695)1.79899084
155Decreased central vision (HP:0007663)1.78815277
156Clumsiness (HP:0002312)1.78697615
157Broad forehead (HP:0000337)1.78680967
158Hypoplasia of the uterus (HP:0000013)1.78240820
159Molar tooth sign on MRI (HP:0002419)1.77181924
160Abnormality of midbrain morphology (HP:0002418)1.77181924
161Renal Fanconi syndrome (HP:0001994)1.75330645
162Myokymia (HP:0002411)1.73960985
163Abnormal auditory evoked potentials (HP:0006958)1.70105309
164Dolichocephaly (HP:0000268)1.68084537
165Myopathic facies (HP:0002058)1.67176115
166Hypoplastic pelvis (HP:0008839)1.65947016
167Renal salt wasting (HP:0000127)1.65715082
168Congenital stationary night blindness (HP:0007642)1.64519386
169Agitation (HP:0000713)1.63620850
170Vitreoretinal degeneration (HP:0000655)1.63517374
171Poor suck (HP:0002033)1.63370935
172Progressive macrocephaly (HP:0004481)1.61973356
173Menstrual irregularities (HP:0000858)1.58947811
174Abnormal tarsal ossification (HP:0008369)1.58141417
175Nasal speech (HP:0001611)1.57214695
176Ulnar bowing (HP:0003031)1.56894846
177Resting tremor (HP:0002322)1.56322829
178Action tremor (HP:0002345)1.55908821
179Proximal placement of thumb (HP:0009623)1.55106728
180Bulbar palsy (HP:0001283)1.54948493
181Diminished movement (HP:0002374)1.52610215
182Ovarian neoplasm (HP:0100615)1.51412570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.50490286
2WEE14.96116921
3TSSK64.08208901
4AKT33.47425807
5PLK43.16252255
6ARAF2.91494054
7BRSK22.57979130
8NME22.52424400
9EIF2AK12.30301421
10NEK22.23780447
11PNCK2.21289138
12TRIM282.21070681
13MARK12.18554820
14SRPK12.16903958
15BMPR1B2.13306161
16BRD42.09462324
17PLK32.05742738
18EPHA22.05368232
19STK161.94194158
20PLK11.91365580
21ZAK1.88906192
22MINK11.85869551
23BRSK11.84264569
24PDK31.84186152
25PDK41.84186152
26MKNK21.78714166
27BRAF1.78336375
28TTK1.77005479
29NEK11.73222582
30PRKD31.59308104
31CAMK1D1.49737576
32PAK31.46687211
33DYRK31.46510269
34NTRK31.46037368
35MKNK11.43441095
36PHKG11.42190676
37PHKG21.42190676
38CCNB11.41480856
39EIF2AK31.41309524
40STK38L1.38053654
41LATS21.31746561
42MAP3K61.26491552
43PDK21.23901339
44MAP3K91.19372863
45AURKB1.18886063
46PRKCH1.18523801
47ERBB31.16555022
48CASK1.14765749
49RPS6KA21.14636527
50MAP2K71.14118474
51TAOK21.14008240
52CAMKK11.11209702
53STK31.08162340
54CHEK21.07174002
55TAOK11.04815632
56ACVR1B1.04807438
57ICK1.04431759
58AURKA1.04049816
59PRPF4B1.02459322
60NTRK21.02153536
61ALK1.01771794
62TYRO31.01639719
63ABL20.97487761
64DYRK1A0.93771310
65PINK10.92538936
66PKN10.91282134
67STK240.88754867
68PRKCI0.87422408
69CAMK1G0.86205397
70PIM20.85651277
71CDK70.85260825
72CDK30.84055768
73CHEK10.83827280
74CDK40.81273893
75OBSCN0.80403680
76CAMK40.78041090
77PAK10.77127618
78MST1R0.76745961
79WNK30.76419589
80DYRK1B0.75852139
81RPS6KL10.75644746
82RPS6KC10.75644746
83LRRK20.75210498
84CDK50.74674661
85MAP3K80.73414555
86RPS6KA60.73200568
87PRKCZ0.71904433
88BCR0.71878700
89CDK140.71249841
90CAMK2A0.70691948
91MYLK0.69276287
92CDC70.69081291
93PRKACA0.68946288
94ADRBK10.68844375
95LIMK10.68250406
96NUAK10.66518679
97GRK50.63946253
98PRKD10.62529661
99ERBB20.61986267
100NME10.59616915
101RAF10.57913615
102INSRR0.57636677
103CDK11A0.57268874
104LATS10.57242609
105CSNK1G30.57182510
106MAP3K40.56880302
107CSNK1G10.56405914
108RPS6KA10.54910845
109CDK180.53850584
110ATR0.53678281
111CSNK1E0.53153033
112CDK20.53054410
113PRKCE0.52657276
114CDK150.52287557
115SGK2230.52097427
116SGK4940.52097427
117UHMK10.49760626
118PASK0.49290415
119SGK30.49040075
120EPHA40.49029020
121CSNK2A10.48890378
122SGK10.48327819
123PRKDC0.47822780
124RPS6KA30.46228377
125CSNK2A20.45702237
126EIF2AK20.45315208
127MARK30.44091165
128STK380.43720623
129ZAP700.42670027
130RPS6KA40.41192639
131TRIB30.41184686
132MAP3K30.41079476
133CDK10.40507415
134RPS6KB20.39396365
135MTOR0.35339188
136CSNK1A1L0.35314508
137VRK10.34129018
138PRKCG0.34023704
139TESK20.34003756
140DYRK20.32390700
141PAK40.32142374
142AKT20.31596795
143IRAK30.30658958
144MAP2K20.28693899
145PRKAA10.28270025
146PAK20.27488862
147BCKDK0.24861092
148MELK0.22746526
149ATM0.21959605
150CSNK1A10.21103094
151LMTK20.20494831
152PLK20.18876073
153CSNK1G20.18163637
154PIM10.18137752
155DAPK30.16830482
156ILK0.13717603
157KSR20.13514572
158RPS6KA50.12836151
159STK40.11680350
160KSR10.11552415

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.64980516
2RNA polymerase_Homo sapiens_hsa030204.94116609
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.48538383
4Proteasome_Homo sapiens_hsa030504.10446100
5RNA transport_Homo sapiens_hsa030133.42674610
6Fatty acid elongation_Homo sapiens_hsa000623.09551108
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.98024367
8Ribosome_Homo sapiens_hsa030102.66480056
9Pyrimidine metabolism_Homo sapiens_hsa002402.62514616
10Spliceosome_Homo sapiens_hsa030402.52354326
11Regulation of autophagy_Homo sapiens_hsa041402.39701253
12DNA replication_Homo sapiens_hsa030302.32505874
13Cell cycle_Homo sapiens_hsa041102.32450540
14Basal transcription factors_Homo sapiens_hsa030222.16952029
15Steroid biosynthesis_Homo sapiens_hsa001002.04553017
16Mismatch repair_Homo sapiens_hsa034301.99743135
17Alzheimers disease_Homo sapiens_hsa050101.97578659
18Nucleotide excision repair_Homo sapiens_hsa034201.94887179
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.82543558
20Propanoate metabolism_Homo sapiens_hsa006401.82132465
21Purine metabolism_Homo sapiens_hsa002301.76718730
22Base excision repair_Homo sapiens_hsa034101.75086341
23Pyruvate metabolism_Homo sapiens_hsa006201.71488522
24Sulfur metabolism_Homo sapiens_hsa009201.70329431
25Homologous recombination_Homo sapiens_hsa034401.61600669
26Folate biosynthesis_Homo sapiens_hsa007901.59529342
27Oocyte meiosis_Homo sapiens_hsa041141.57512731
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.56740764
29Synaptic vesicle cycle_Homo sapiens_hsa047211.56637129
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55119063
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52471259
32Nicotine addiction_Homo sapiens_hsa050331.52129749
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49177876
34mRNA surveillance pathway_Homo sapiens_hsa030151.39039084
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.33508471
36Vibrio cholerae infection_Homo sapiens_hsa051101.32849683
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32597762
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29955324
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29239569
40Pentose phosphate pathway_Homo sapiens_hsa000301.28003109
41p53 signaling pathway_Homo sapiens_hsa041151.27318737
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.25665088
43Vitamin digestion and absorption_Homo sapiens_hsa049771.21490863
44Epstein-Barr virus infection_Homo sapiens_hsa051691.18643815
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17318086
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16143000
47Fanconi anemia pathway_Homo sapiens_hsa034601.11435339
48Fatty acid metabolism_Homo sapiens_hsa012121.11394995
49RNA degradation_Homo sapiens_hsa030181.11000137
50Biosynthesis of amino acids_Homo sapiens_hsa012301.09360449
51Melanogenesis_Homo sapiens_hsa049161.08156957
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03920103
53Tyrosine metabolism_Homo sapiens_hsa003501.03099528
54Basal cell carcinoma_Homo sapiens_hsa052170.99853631
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.99591486
56Sulfur relay system_Homo sapiens_hsa041220.97174096
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95202359
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93749505
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92874755
60GABAergic synapse_Homo sapiens_hsa047270.92129008
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91777079
62Fructose and mannose metabolism_Homo sapiens_hsa000510.91438981
63Morphine addiction_Homo sapiens_hsa050320.91290884
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90564707
65Chemical carcinogenesis_Homo sapiens_hsa052040.87865516
66Phototransduction_Homo sapiens_hsa047440.84580975
67Carbon metabolism_Homo sapiens_hsa012000.82671334
68Galactose metabolism_Homo sapiens_hsa000520.79593472
69Ovarian steroidogenesis_Homo sapiens_hsa049130.79582647
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77850390
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77471654
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76376255
73One carbon pool by folate_Homo sapiens_hsa006700.76186205
74Dopaminergic synapse_Homo sapiens_hsa047280.75830844
75Cocaine addiction_Homo sapiens_hsa050300.75101738
76Circadian entrainment_Homo sapiens_hsa047130.74970121
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74891990
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72855022
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72247576
80Huntingtons disease_Homo sapiens_hsa050160.70906913
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68487555
82Glutamatergic synapse_Homo sapiens_hsa047240.64025940
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60907841
84Hippo signaling pathway_Homo sapiens_hsa043900.59462925
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57457014
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.57045608
87Peroxisome_Homo sapiens_hsa041460.56124097
88Axon guidance_Homo sapiens_hsa043600.52826117
89Glutathione metabolism_Homo sapiens_hsa004800.52544364
90mTOR signaling pathway_Homo sapiens_hsa041500.51477674
91Hedgehog signaling pathway_Homo sapiens_hsa043400.51432348
92Metabolic pathways_Homo sapiens_hsa011000.50845357
93Antigen processing and presentation_Homo sapiens_hsa046120.50272879
94Cholinergic synapse_Homo sapiens_hsa047250.48025901
95Parkinsons disease_Homo sapiens_hsa050120.47857332
96Circadian rhythm_Homo sapiens_hsa047100.47818607
97Phenylalanine metabolism_Homo sapiens_hsa003600.43538440
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.42972726
99Sphingolipid metabolism_Homo sapiens_hsa006000.42534214
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.41785237
101Wnt signaling pathway_Homo sapiens_hsa043100.41749695
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40906157
103cAMP signaling pathway_Homo sapiens_hsa040240.39527701
104Tight junction_Homo sapiens_hsa045300.39312912
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39265547
106Fatty acid biosynthesis_Homo sapiens_hsa000610.39215871
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39086625
108Arachidonic acid metabolism_Homo sapiens_hsa005900.38715396
109Cardiac muscle contraction_Homo sapiens_hsa042600.38664120
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37833640
111Alcoholism_Homo sapiens_hsa050340.37547125
112Arginine and proline metabolism_Homo sapiens_hsa003300.37394847
113Thyroid cancer_Homo sapiens_hsa052160.36418115
114Oxidative phosphorylation_Homo sapiens_hsa001900.35788106
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34246935
116Selenocompound metabolism_Homo sapiens_hsa004500.34242561
117Amphetamine addiction_Homo sapiens_hsa050310.31282824
118Fatty acid degradation_Homo sapiens_hsa000710.30600911
119Prion diseases_Homo sapiens_hsa050200.30231727
120HIF-1 signaling pathway_Homo sapiens_hsa040660.29513973
121Small cell lung cancer_Homo sapiens_hsa052220.29512541
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28870287
123Collecting duct acid secretion_Homo sapiens_hsa049660.28641606
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26689265
125Linoleic acid metabolism_Homo sapiens_hsa005910.24578143
126Mineral absorption_Homo sapiens_hsa049780.23899279
127Viral carcinogenesis_Homo sapiens_hsa052030.23737023
128FoxO signaling pathway_Homo sapiens_hsa040680.22574334
129Lysosome_Homo sapiens_hsa041420.22370059
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.19832228
131Glycerolipid metabolism_Homo sapiens_hsa005610.18840429
132HTLV-I infection_Homo sapiens_hsa051660.14275931
133AMPK signaling pathway_Homo sapiens_hsa041520.13840969
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.13550144
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.13231752
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.12207972
137Prostate cancer_Homo sapiens_hsa052150.11546767
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.09378456
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08632643
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.07317847
141Renal cell carcinoma_Homo sapiens_hsa052110.07289161
142Insulin signaling pathway_Homo sapiens_hsa049100.07214474
143Non-homologous end-joining_Homo sapiens_hsa034500.05938625
144TGF-beta signaling pathway_Homo sapiens_hsa043500.04815785
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.04362949
146Protein export_Homo sapiens_hsa030600.02829631
147Renin-angiotensin system_Homo sapiens_hsa046140.02208067
148Inositol phosphate metabolism_Homo sapiens_hsa005620.02152945
149Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.01997808
150beta-Alanine metabolism_Homo sapiens_hsa004100.01869609
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.01577845

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