CITED2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of hypoxia-inducible factor 1-alpha to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)4.45786895
2cell migration involved in heart development (GO:0060973)4.04097963
3protein heterotrimerization (GO:0070208)4.04064931
4bone trabecula formation (GO:0060346)3.57887793
5planar cell polarity pathway involved in neural tube closure (GO:0090179)3.56704666
6kidney mesenchyme development (GO:0072074)3.52960253
7negative regulation of smooth muscle cell migration (GO:0014912)3.50203042
8type B pancreatic cell proliferation (GO:0044342)3.41646497
9regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.38624810
10hypotonic response (GO:0006971)3.37247903
11adhesion of symbiont to host cell (GO:0044650)3.33033685
12virion attachment to host cell (GO:0019062)3.33033685
13cell-substrate adherens junction assembly (GO:0007045)3.29792706
14focal adhesion assembly (GO:0048041)3.29792706
15atrioventricular valve morphogenesis (GO:0003181)3.29356196
16adherens junction assembly (GO:0034333)3.26646782
17barbed-end actin filament capping (GO:0051016)3.24990318
18Arp2/3 complex-mediated actin nucleation (GO:0034314)3.19039521
19negative regulation of fatty acid transport (GO:2000192)3.17177027
20extracellular matrix assembly (GO:0085029)3.17029330
21stress fiber assembly (GO:0043149)3.16636811
22sequestering of extracellular ligand from receptor (GO:0035581)3.15959396
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.14109632
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.14109632
25modulation by symbiont of host immune response (GO:0052553)3.14109632
26positive regulation by symbiont of host defense response (GO:0052509)3.14109632
27modulation by symbiont of host defense response (GO:0052031)3.14109632
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.14109632
29protein localization to endosome (GO:0036010)3.13937477
30adhesion of symbiont to host (GO:0044406)3.11334884
31blood vessel maturation (GO:0001955)3.10880147
32cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.08459266
33chondrocyte proliferation (GO:0035988)3.07569048
34collagen metabolic process (GO:0032963)3.05424108
35positive regulation of p38MAPK cascade (GO:1900745)3.05226362
36positive regulation of histone deacetylation (GO:0031065)3.04685259
37negative regulation of phagocytosis (GO:0050765)3.04445756
38germ cell migration (GO:0008354)3.03155592
39endodermal cell differentiation (GO:0035987)3.02484042
40metanephric mesenchyme development (GO:0072075)3.02442666
41response to muramyl dipeptide (GO:0032495)2.98886353
42cell adhesion mediated by integrin (GO:0033627)2.98003060
43vascular endothelial growth factor signaling pathway (GO:0038084)2.97970322
44positive regulation of blood vessel endothelial cell migration (GO:0043536)2.95024933
45mannose metabolic process (GO:0006013)2.91790906
46response to peptidoglycan (GO:0032494)2.89617266
47endothelial cell morphogenesis (GO:0001886)2.89026211
48positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.88412835
49regulation of transforming growth factor beta1 production (GO:0032908)2.85066803
50hyaluronan catabolic process (GO:0030214)2.85057118
51positive regulation of osteoblast proliferation (GO:0033690)2.83991916
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.83805971
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.83805971
54cell migration involved in sprouting angiogenesis (GO:0002042)2.83003032
55negative regulation of erythrocyte differentiation (GO:0045647)2.81887311
563-UTR-mediated mRNA stabilization (GO:0070935)2.81030454
57chondrocyte development (GO:0002063)2.80901053
58multicellular organismal macromolecule metabolic process (GO:0044259)2.79224735
59collagen catabolic process (GO:0030574)2.78943687
60positive regulation of natural killer cell differentiation (GO:0032825)2.78644920
61epithelial cell-cell adhesion (GO:0090136)2.78153926
62vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.77337620
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77200858
64response to interferon-alpha (GO:0035455)2.77021003
65neutrophil activation involved in immune response (GO:0002283)2.73490285
66wound healing, spreading of cells (GO:0044319)2.69071778
67multicellular organismal metabolic process (GO:0044236)2.67381494
68positive regulation of extracellular matrix organization (GO:1903055)2.66557227
69cellular response to interferon-alpha (GO:0035457)2.65908708
70definitive hemopoiesis (GO:0060216)2.65527674
71cellular response to vitamin (GO:0071295)2.65148316
72platelet aggregation (GO:0070527)2.64933798
73negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.63876610
74polarized epithelial cell differentiation (GO:0030859)2.63446243
75heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.63319302
76blood vessel endothelial cell migration (GO:0043534)2.62999435
77protein targeting to plasma membrane (GO:0072661)2.62903190
78T cell apoptotic process (GO:0070231)2.62726454
79tooth mineralization (GO:0034505)2.62666415
80basement membrane organization (GO:0071711)2.61683696
81mesenchymal-epithelial cell signaling (GO:0060638)2.61515880
82negative regulation of homotypic cell-cell adhesion (GO:0034111)2.60789963
83natural killer cell differentiation (GO:0001779)2.60411854
84positive regulation of interferon-alpha production (GO:0032727)2.60277380
85wound healing, spreading of epidermal cells (GO:0035313)2.60040416
86negative regulation of skeletal muscle tissue development (GO:0048642)2.58898242
87actin nucleation (GO:0045010)2.58269493
88negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.58130580
89pinocytosis (GO:0006907)2.58100294
90lymph vessel development (GO:0001945)2.56282824
91regulation of integrin activation (GO:0033623)2.56264150
92substrate adhesion-dependent cell spreading (GO:0034446)2.56119452
93substrate-dependent cell migration (GO:0006929)2.55529488
94cortical actin cytoskeleton organization (GO:0030866)2.54496813
95regulation of interferon-beta biosynthetic process (GO:0045357)2.54351732
96multicellular organismal catabolic process (GO:0044243)2.54055282
97negative regulation of granulocyte differentiation (GO:0030853)2.53391919
98endocytic recycling (GO:0032456)2.53388295
99regulation of interleukin-12 biosynthetic process (GO:0045075)2.53326115
100pericardium development (GO:0060039)2.52920954
101response to laminar fluid shear stress (GO:0034616)2.52128700
102extracellular matrix disassembly (GO:0022617)2.50660449
103positive regulation of SMAD protein import into nucleus (GO:0060391)2.50476804
104regulation of SMAD protein import into nucleus (GO:0060390)2.49983842
105apoptotic cell clearance (GO:0043277)2.49949460
106positive regulation of fibroblast migration (GO:0010763)2.49080012
107positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.47528379
108venous blood vessel morphogenesis (GO:0048845)2.46831681
109regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.46125200
110regulation of interferon-alpha production (GO:0032647)2.44769985
111maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.44757465
112mRNA stabilization (GO:0048255)2.44233383
113RNA stabilization (GO:0043489)2.44233383
114regulation of extracellular matrix disassembly (GO:0010715)2.44127299
115positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.42983135
116hepatocyte apoptotic process (GO:0097284)2.42463495
117fibril organization (GO:0097435)2.42424087
118regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.41507703
119positive regulation of cartilage development (GO:0061036)2.41467408
120extracellular fibril organization (GO:0043206)2.41064003
121negative regulation of embryonic development (GO:0045992)2.41016738
122trabecula formation (GO:0060343)2.40193401
123negative regulation of biomineral tissue development (GO:0070168)2.38924875
124positive regulation of endothelial cell apoptotic process (GO:2000353)2.38205843
125Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.38182202
126antigen processing and presentation of endogenous antigen (GO:0019883)2.38087821
127leukocyte aggregation (GO:0070486)2.38021370
128regulation of protein heterodimerization activity (GO:0043497)2.38009480
129* endocardial cushion development (GO:0003197)2.37221579
130antigen processing and presentation via MHC class Ib (GO:0002475)2.36614424
131positive regulation of vasculogenesis (GO:2001214)2.36570737
132extracellular negative regulation of signal transduction (GO:1900116)2.35911874
133extracellular regulation of signal transduction (GO:1900115)2.35911874
134mammary gland epithelial cell proliferation (GO:0033598)2.35509357
135membrane raft organization (GO:0031579)2.35148949
136positive regulation of protein deacetylation (GO:0090312)2.34930251
137cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.34659250
138production of molecular mediator involved in inflammatory response (GO:0002532)2.34179696
139glucocorticoid receptor signaling pathway (GO:0042921)2.33875261
140maternal placenta development (GO:0001893)2.33016025
141regulation of establishment of planar polarity (GO:0090175)2.32330222
142lipopolysaccharide-mediated signaling pathway (GO:0031663)2.32213561
143insulin-like growth factor receptor signaling pathway (GO:0048009)2.31594312
144regulation of erythrocyte differentiation (GO:0045646)2.29824291
145regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.29112523
146sequestering of metal ion (GO:0051238)2.28649961
147cell-substrate junction assembly (GO:0007044)2.28502159
148positive regulation of epithelial to mesenchymal transition (GO:0010718)2.27987481
149response to fungus (GO:0009620)2.27740523
150response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.27005247
151response to host (GO:0075136)2.27005247
152response to host defenses (GO:0052200)2.27005247
153skin morphogenesis (GO:0043589)2.26095905
154negative regulation of cell size (GO:0045792)2.24745876
155positive regulation of macrophage differentiation (GO:0045651)2.23712452
156immunoglobulin mediated immune response (GO:0016064)2.23600955
157mRNA transcription (GO:0009299)2.23413114
158lymphocyte apoptotic process (GO:0070227)2.22977681
159regulation of p38MAPK cascade (GO:1900744)2.22597137
160positive regulation of leukocyte degranulation (GO:0043302)2.20574126
161mesodermal cell differentiation (GO:0048333)2.19242952
162granulocyte activation (GO:0036230)2.18740809
163apoptotic process involved in morphogenesis (GO:0060561)2.18721340
164heterochromatin organization (GO:0070828)2.18252222
165homotypic cell-cell adhesion (GO:0034109)2.17924893
166activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.17420487
167protein retention in ER lumen (GO:0006621)2.17404260
168regulation of hippo signaling (GO:0035330)2.17293598
169positive regulation of gamma-delta T cell activation (GO:0046645)2.17062846
170regulation of early endosome to late endosome transport (GO:2000641)2.16290366
171myeloid cell homeostasis (GO:0002262)2.16246297
172regulation of T-helper 1 cell differentiation (GO:0045625)2.16226834
173macrophage activation involved in immune response (GO:0002281)2.15208005
174ribosomal small subunit assembly (GO:0000028)2.15027854
175positive regulation of nuclease activity (GO:0032075)2.13212882
176Golgi transport vesicle coating (GO:0048200)2.12078571
177COPI coating of Golgi vesicle (GO:0048205)2.12078571

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.38343008
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.71395486
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.71245969
4MYC_22102868_ChIP-Seq_BL_Human2.80526444
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.57748369
6* VDR_21846776_ChIP-Seq_THP-1_Human2.51539795
7* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.51132403
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.49251292
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46017546
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.45244278
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.43938449
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.43445191
13SCL_19346495_ChIP-Seq_HPC-7_Human2.34417928
14* TCF7_22412390_ChIP-Seq_EML_Mouse2.30349438
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.26840201
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.23774899
17* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23445691
18* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23247629
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.22490208
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12294798
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.08704668
22* VDR_24763502_ChIP-Seq_THP-1_Human2.03845494
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.02168213
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.01079099
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.00150308
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95967951
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.95667820
28* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94701145
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93655599
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.90510579
31MAF_26560356_Chip-Seq_TH1_Human1.89720741
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.88612710
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88055595
34KDM2B_26808549_Chip-Seq_DND41_Human1.84662959
35* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83420966
36* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.75819745
37UTX_26944678_Chip-Seq_JUKART_Human1.75736130
38CLOCK_20551151_ChIP-Seq_293T_Human1.73899114
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70212212
40KDM2B_26808549_Chip-Seq_K562_Human1.70039317
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.68719833
42* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68701091
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67330005
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.65162292
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.64776611
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59711097
47* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58146557
48* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56148057
49* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55558638
50ATF3_27146783_Chip-Seq_COLON_Human1.52327643
51* SPI1_23547873_ChIP-Seq_NB4_Human1.51593989
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50944232
53* MYB_26560356_Chip-Seq_TH2_Human1.49982287
54* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.48580007
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47097378
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46937078
57* RACK7_27058665_Chip-Seq_MCF-7_Human1.46402663
58* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43953373
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.43361556
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.42728682
61GATA1_19941826_ChIP-Seq_K562_Human1.41724641
62* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40649805
63MYB_26560356_Chip-Seq_TH1_Human1.40228266
64NCOR1_26117541_ChIP-Seq_K562_Human1.37626523
65* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36450577
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35687783
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35461927
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33756053
69* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33039611
70* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32562200
71* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32188949
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32178947
73LXR_22292898_ChIP-Seq_THP-1_Human1.31669067
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31585210
75E2F7_22180533_ChIP-Seq_HELA_Human1.30718316
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29627661
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29174833
78UBF1/2_26484160_Chip-Seq_HMECs_Human1.28724643
79* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28714798
80SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28556042
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28556042
82SPI1_23127762_ChIP-Seq_K562_Human1.27554981
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26283410
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25405209
85* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24891224
86* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24748449
87KDM2B_26808549_Chip-Seq_JURKAT_Human1.24733243
88TBX20_22328084_ChIP-Seq_HEART_Mouse1.23901957
89TBX20_22080862_ChIP-Seq_HEART_Mouse1.23901957
90ESR1_21235772_ChIP-Seq_MCF-7_Human1.23875077
91DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22511346
92* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21300597
93EED_16625203_ChIP-ChIP_MESCs_Mouse1.21297025
94* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21083868
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20798721
96* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20283426
97* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19822911
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19220315
99* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.15905289
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15175461
101ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14738680
102EP300_21415370_ChIP-Seq_HL-1_Mouse1.14667261
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13083964
104* CJUN_26792858_Chip-Seq_BT549_Human1.12649548
105* PU_27001747_Chip-Seq_BMDM_Mouse1.12588776
106* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.11835562
107ZNF263_19887448_ChIP-Seq_K562_Human1.10298574
108* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09372230
109* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09279208
110GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08575493
111ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08427686
112RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05758660
113EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05758660
114CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04674362
115FOXO3_23340844_ChIP-Seq_DLD1_Human1.04665079
116* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04658929
117CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04368142
118TFEB_21752829_ChIP-Seq_HELA_Human1.04131434
119* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03854543
120* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03542155
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03240231
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03192711
123MAF_26560356_Chip-Seq_TH2_Human1.02655778
124GATA2_21666600_ChIP-Seq_HMVEC_Human1.02551869
125* SA1_22415368_ChIP-Seq_MEFs_Mouse1.02508846
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02167713
127GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02100449
128SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01928602
129WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01636262
130TP53_23651856_ChIP-Seq_MEFs_Mouse1.00798092
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00149280
132SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00146154
133SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99264081
134RUNX_20019798_ChIP-Seq_JUKART_Human0.99122262
135GATA6_25053715_ChIP-Seq_YYC3_Human0.98434577
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96815779
137TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95961684
138* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95663819
139TP53_22127205_ChIP-Seq_IMR90_Human0.94363716
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94357947
141* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94192267
142BRD4_25478319_ChIP-Seq_HGPS_Human0.93658558
143STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93423699
144THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92918744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology4.17340355
2MP0003303_peritoneal_inflammation3.17315820
3MP0003705_abnormal_hypodermis_morpholog3.14959943
4MP0010352_gastrointestinal_tract_polyps2.90452608
5MP0001542_abnormal_bone_strength2.63046931
6MP0005257_abnormal_intraocular_pressure2.61948656
7MP0003566_abnormal_cell_adhesion2.57276871
8MP0005076_abnormal_cell_differentiation2.55885202
9MP0009278_abnormal_bone_marrow2.53453277
10MP0003436_decreased_susceptibility_to2.51898654
11MP0003300_gastrointestinal_ulcer2.33520616
12MP0002877_abnormal_melanocyte_morpholog2.23882281
13MP0005623_abnormal_meninges_morphology2.19989534
14MP0008438_abnormal_cutaneous_collagen1.98414899
15MP0004808_abnormal_hematopoietic_stem1.91618895
16MP0003091_abnormal_cell_migration1.86154767
17MP0003279_aneurysm1.84250595
18* MP0009384_cardiac_valve_regurgitation1.82605709
19MP0000858_altered_metastatic_potential1.76580206
20MP0005397_hematopoietic_system_phenotyp1.76130353
21MP0001545_abnormal_hematopoietic_system1.76130353
22MP0003950_abnormal_plasma_membrane1.72120555
23MP0005023_abnormal_wound_healing1.71353231
24MP0009785_altered_susceptibility_to1.70590221
25MP0006054_spinal_hemorrhage1.69778964
26MP0000733_abnormal_muscle_development1.61858837
27MP0000013_abnormal_adipose_tissue1.58710060
28MP0001835_abnormal_antigen_presentation1.54289991
29MP0002148_abnormal_hypersensitivity_rea1.53015813
30MP0004947_skin_inflammation1.52337345
31MP0002419_abnormal_innate_immunity1.51715274
32MP0001533_abnormal_skeleton_physiology1.50326847
33MP0005464_abnormal_platelet_physiology1.49217458
34MP0002396_abnormal_hematopoietic_system1.47287435
35MP0004510_myositis1.44443968
36MP0005000_abnormal_immune_tolerance1.43250865
37MP0003828_pulmonary_edema1.42587732
38MP0000490_abnormal_crypts_of1.42469612
39MP0000685_abnormal_immune_system1.41998263
40MP0002452_abnormal_antigen_presenting1.41580123
41MP0009250_abnormal_appendicular_skeleto1.40171518
42MP0004272_abnormal_basement_membrane1.38768906
43MP0000534_abnormal_ureter_morphology1.38226125
44MP0003448_altered_tumor_morphology1.36897967
45MP0002108_abnormal_muscle_morphology1.36025913
46MP0000465_gastrointestinal_hemorrhage1.35900713
47MP0000003_abnormal_adipose_tissue1.35133100
48MP0002405_respiratory_system_inflammati1.35092588
49MP0004858_abnormal_nervous_system1.32977649
50MP0002295_abnormal_pulmonary_circulatio1.32730168
51MP0005025_abnormal_response_to1.31413215
52MP0000343_altered_response_to1.29217930
53MP0001243_abnormal_dermal_layer1.28083802
54MP0005595_abnormal_vascular_smooth1.27675276
55MP0010307_abnormal_tumor_latency1.27602365
56MP0000750_abnormal_muscle_regeneration1.26303270
57MP0009840_abnormal_foam_cell1.26211041
58MP0000767_abnormal_smooth_muscle1.23521340
59MP0000751_myopathy1.23103331
60MP0010030_abnormal_orbit_morphology1.22304797
61MP0001819_abnormal_immune_cell1.21094636
62MP0005387_immune_system_phenotype1.20555009
63MP0001790_abnormal_immune_system1.20555009
64MP0010155_abnormal_intestine_physiology1.20337592
65MP0006082_CNS_inflammation1.19743830
66MP0002420_abnormal_adaptive_immunity1.19570465
67MP0002723_abnormal_immune_serum1.17352223
68MP0001800_abnormal_humoral_immune1.15550571
69MP0001958_emphysema1.14185156
70MP0003172_abnormal_lysosome_physiology1.13450598
71MP0002166_altered_tumor_susceptibility1.13373346
72MP0005058_abnormal_lysosome_morphology1.13068647
73MP0003453_abnormal_keratinocyte_physiol1.11978041
74MP0009780_abnormal_chondrocyte_physiolo1.11927962
75MP0001915_intracranial_hemorrhage1.11226974
76MP0005390_skeleton_phenotype1.10260186
77MP0002398_abnormal_bone_marrow1.07232463
78MP0002998_abnormal_bone_remodeling1.06532853
79MP0008007_abnormal_cellular_replicative1.06456280
80* MP0003942_abnormal_urinary_system1.02237402
81MP0005275_abnormal_skin_tensile1.00560160
82MP0009333_abnormal_splenocyte_physiolog0.99683767
83MP0004185_abnormal_adipocyte_glucose0.98783877
84MP0001845_abnormal_inflammatory_respons0.98640885
85MP0000759_abnormal_skeletal_muscle0.98462480
86MP0010234_abnormal_vibrissa_follicle0.95651988
87MP0002933_joint_inflammation0.95015203
88MP0003567_abnormal_fetal_cardiomyocyte0.94996099
89MP0001853_heart_inflammation0.94800994
90MP0005375_adipose_tissue_phenotype0.93853133
91MP0001849_ear_inflammation0.93614079
92MP0000716_abnormal_immune_system0.92704702
93MP0002006_tumorigenesis0.92325210
94MP0009053_abnormal_anal_canal0.92107554
95MP0001873_stomach_inflammation0.91796216
96* MP0002722_abnormal_immune_system0.88667802
97MP0005409_darkened_coat_color0.87403731
98MP0003795_abnormal_bone_structure0.87285634
99* MP0004197_abnormal_fetal_growth/weight/0.86241131
100MP0002086_abnormal_extraembryonic_tissu0.85951567
101MP0000428_abnormal_craniofacial_morphol0.85941505
102MP0002429_abnormal_blood_cell0.85708775
103MP0010368_abnormal_lymphatic_system0.85098848
104MP0003724_increased_susceptibility_to0.84337952
105MP0008961_abnormal_basal_metabolism0.84202895
106MP0006138_congestive_heart_failure0.83589985
107MP0000681_abnormal_thyroid_gland0.83547498
108MP0001348_abnormal_lacrimal_gland0.83301957
109MP0002896_abnormal_bone_mineralization0.83051045
110MP0001881_abnormal_mammary_gland0.82693996
111MP0001299_abnormal_eye_distance/0.82121648
112MP0002115_abnormal_skeleton_extremities0.81981208
113MP0000163_abnormal_cartilage_morphology0.81327891
114MP0010386_abnormal_urinary_bladder0.81283499
115* MP0000689_abnormal_spleen_morphology0.80638075
116* MP0002925_abnormal_cardiovascular_devel0.79987680
117MP0008004_abnormal_stomach_pH0.79794677
118MP0005388_respiratory_system_phenotype0.79764574
119MP0002133_abnormal_respiratory_system0.79764574
120MP0004264_abnormal_extraembryonic_tissu0.79032351
121* MP0001614_abnormal_blood_vessel0.78819666
122MP0002009_preneoplasia0.78725543
123MP0004233_abnormal_muscle_weight0.77748075
124MP0000249_abnormal_blood_vessel0.77656840
125MP0003941_abnormal_skin_development0.77389042
126MP0003191_abnormal_cellular_cholesterol0.77245380
127MP0010630_abnormal_cardiac_muscle0.76797892
128MP0002060_abnormal_skin_morphology0.76692090
129MP0005508_abnormal_skeleton_morphology0.75534298
130MP0005164_abnormal_response_to0.75273830
131MP0001879_abnormal_lymphatic_vessel0.74994865
132MP0004087_abnormal_muscle_fiber0.74926777
133MP0002113_abnormal_skeleton_development0.74639006
134MP0002796_impaired_skin_barrier0.74588349
135MP0005671_abnormal_response_to0.74010675
136* MP0002128_abnormal_blood_circulation0.73788436
137MP0003283_abnormal_digestive_organ0.73764983
138MP0005621_abnormal_cell_physiology0.73655853
139MP0001851_eye_inflammation0.72987032
140MP0005501_abnormal_skin_physiology0.72735007
141MP0004134_abnormal_chest_morphology0.72642379
142MP0004130_abnormal_muscle_cell0.72282881
143MP0003385_abnormal_body_wall0.72168048
144MP0000762_abnormal_tongue_morphology0.72129944
145MP0004782_abnormal_surfactant_physiolog0.70970788
146MP0003115_abnormal_respiratory_system0.68992502
147* MP0001175_abnormal_lung_morphology0.68873881
148MP0000350_abnormal_cell_proliferation0.68181487
149MP0003656_abnormal_erythrocyte_physiolo0.65201167
150MP0004883_abnormal_blood_vessel0.64232707
151MP0002249_abnormal_larynx_morphology0.63603036

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.84192695
2Vascular tortuosity (HP:0004948)3.82685717
3Soft skin (HP:0000977)3.40194965
4Premature rupture of membranes (HP:0001788)3.37972366
5Arterial tortuosity (HP:0005116)3.27164079
6Eczematoid dermatitis (HP:0000976)3.22602873
7Neonatal short-limb short stature (HP:0008921)3.22334292
8Recurrent abscess formation (HP:0002722)3.09333282
9Interstitial pulmonary disease (HP:0006530)3.08684837
10Abnormality of dentin (HP:0010299)3.06278962
11Increased density of long bones (HP:0006392)3.04732004
12Broad metatarsal (HP:0001783)3.03355635
13Cerebral aneurysm (HP:0004944)3.02065415
14Hematochezia (HP:0002573)2.96225225
15Fragile skin (HP:0001030)2.85797515
16Recurrent bacterial skin infections (HP:0005406)2.83138024
17Cervical subluxation (HP:0003308)2.81206871
18Shallow orbits (HP:0000586)2.78404080
19Petechiae (HP:0000967)2.74614951
20Follicular hyperkeratosis (HP:0007502)2.72479300
21Mitral regurgitation (HP:0001653)2.70864508
22Biconcave vertebral bodies (HP:0004586)2.66970562
23Increased variability in muscle fiber diameter (HP:0003557)2.65014584
24Peritonitis (HP:0002586)2.64683390
25Thrombocytosis (HP:0001894)2.63412264
26Sparse lateral eyebrow (HP:0005338)2.61815470
27Vertebral compression fractures (HP:0002953)2.58899550
28Slender build (HP:0001533)2.51598529
29Myositis (HP:0100614)2.50415725
30Aortic regurgitation (HP:0001659)2.50272428
31Joint laxity (HP:0001388)2.50247455
32Cellulitis (HP:0100658)2.44835687
33Disproportionate tall stature (HP:0001519)2.42332722
34Aortic aneurysm (HP:0004942)2.41418576
35Impaired platelet aggregation (HP:0003540)2.40408066
36Abnormal platelet function (HP:0011869)2.40408066
37Abnormal platelet volume (HP:0011876)2.35710628
38Mildly elevated creatine phosphokinase (HP:0008180)2.35604456
39Joint stiffness (HP:0001387)2.34062767
40Wide anterior fontanel (HP:0000260)2.33881748
41Abnormality of skeletal muscle fiber size (HP:0012084)2.33763832
42Hyperextensible skin (HP:0000974)2.33453778
43Increased mean platelet volume (HP:0011877)2.32102494
44Overgrowth (HP:0001548)2.31395714
45Rectal prolapse (HP:0002035)2.23575737
46Bowel diverticulosis (HP:0005222)2.22369582
47Increased cerebral lipofuscin (HP:0011813)2.21590151
48Upper limb amyotrophy (HP:0009129)2.21402218
49Distal upper limb amyotrophy (HP:0007149)2.21402218
50Osteolytic defects of the phalanges of the hand (HP:0009771)2.21049580
51Osteolytic defects of the hand bones (HP:0009699)2.21049580
52Spinal cord lesions (HP:0100561)2.19703045
53Syringomyelia (HP:0003396)2.19703045
54Atrophic scars (HP:0001075)2.19388175
55Dilatation of the ascending aorta (HP:0005111)2.14827122
56Aortic valve stenosis (HP:0001650)2.14791212
57Aortic dissection (HP:0002647)2.13334403
58Autoimmune thrombocytopenia (HP:0001973)2.12218674
59Elevated erythrocyte sedimentation rate (HP:0003565)2.12156069
60Thin bony cortex (HP:0002753)2.11800901
61Distal lower limb muscle weakness (HP:0009053)2.11039566
62Absent frontal sinuses (HP:0002688)2.09719759
63Achilles tendon contracture (HP:0001771)2.07442559
64Abnormal delivery (HP:0001787)2.06826985
65Aneurysm (HP:0002617)2.06531599
66Hand muscle atrophy (HP:0009130)2.05874490
67Spontaneous hematomas (HP:0007420)2.04798304
68Coronal craniosynostosis (HP:0004440)2.03859019
69Mediastinal lymphadenopathy (HP:0100721)2.03521067
70Mitral stenosis (HP:0001718)2.02613608
71Arterial thrombosis (HP:0004420)2.01882842
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.01816675
73Orchitis (HP:0100796)2.01773435
74Camptodactyly of toe (HP:0001836)2.01706522
75Subacute progressive viral hepatitis (HP:0006572)2.01697976
76Round ear (HP:0100830)2.01325979
77Ankle contracture (HP:0006466)2.01308829
78Nonimmune hydrops fetalis (HP:0001790)1.99469897
79Enlarged penis (HP:0000040)1.98359857
80Hypoventilation (HP:0002791)1.97683006
81Urinary glycosaminoglycan excretion (HP:0003541)1.95484948
82Mucopolysacchariduria (HP:0008155)1.95484948
83Mitral valve prolapse (HP:0001634)1.95266593
84Radial bowing (HP:0002986)1.94649494
85Difficulty climbing stairs (HP:0003551)1.93288495
86Ulnar deviation of the wrist (HP:0003049)1.93224355
87Broad face (HP:0000283)1.91935183
88Prolonged bleeding time (HP:0003010)1.91794526
89Spinal rigidity (HP:0003306)1.91402353
90Short nail (HP:0001799)1.91021797
91Persistence of primary teeth (HP:0006335)1.90482732
92Spondylolisthesis (HP:0003302)1.90073660
93Long toe (HP:0010511)1.88670857
94Deviation of the thumb (HP:0009603)1.88283464
95Natal tooth (HP:0000695)1.88120976
96Dysostosis multiplex (HP:0000943)1.86633059
97Short clavicles (HP:0000894)1.86303847
98Increased connective tissue (HP:0009025)1.86295704
99Blue sclerae (HP:0000592)1.85009821
100Chest pain (HP:0100749)1.84553583
101Abnormal ossification of hand bones (HP:0005921)1.83795895
102Genu recurvatum (HP:0002816)1.83476542
103Hypoplasia of the iris (HP:0007676)1.82333995
104Abnormality of macrophages (HP:0004311)1.82218502
105Abnormality of the Achilles tendon (HP:0005109)1.81222424
106Menorrhagia (HP:0000132)1.81074513
107Abnormality of carpal bone ossification (HP:0006257)1.80674457
108Recurrent fungal infections (HP:0002841)1.80369545
109Ovoid vertebral bodies (HP:0003300)1.79327892
110Cardiovascular calcification (HP:0011915)1.77818969
111Delayed cranial suture closure (HP:0000270)1.77239972
112Axonal loss (HP:0003447)1.75644651
113Ectopia lentis (HP:0001083)1.75283530
114Hyperacusis (HP:0010780)1.74861366
115Abnormality of skull ossification (HP:0002703)1.74672793
116Wormian bones (HP:0002645)1.74567900
117Mesomelia (HP:0003027)1.74110837
118Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73598840
119Abnormality of polysaccharide metabolism (HP:0011012)1.73598840
120Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73598840
121Abnormality of the pericardium (HP:0001697)1.73082011
122Distal lower limb amyotrophy (HP:0008944)1.72871531
123Inguinal hernia (HP:0000023)1.72399379
124Flared iliac wings (HP:0002869)1.72130164
125Vacuolated lymphocytes (HP:0001922)1.71632510
126Abnormality of the distal phalanges of the toes (HP:0010182)1.71487916
127Generalized amyotrophy (HP:0003700)1.71446364
128Epistaxis (HP:0000421)1.71303907
129Frequent falls (HP:0002359)1.70592328
130Exostoses (HP:0100777)1.70582363
131Venous abnormality (HP:0002624)1.70228261
132Obstructive sleep apnea (HP:0002870)1.70151268
133Aplasia of the musculature (HP:0100854)1.69135253
134Type 1 muscle fiber predominance (HP:0003803)1.68696725
135Long eyelashes (HP:0000527)1.68364723
136Ulnar bowing (HP:0003031)1.68314189
137Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.68296455
138Recurrent viral infections (HP:0004429)1.67935292
139Abnormality of the phalanges of the hallux (HP:0010057)1.67929972
140Premature skin wrinkling (HP:0100678)1.67718093
141Retinal atrophy (HP:0001105)1.67344279
142Coxa vara (HP:0002812)1.67295584
143Micronodular cirrhosis (HP:0001413)1.66863965
144Right ventricular cardiomyopathy (HP:0011663)1.66225270
145Lymphangioma (HP:0100764)1.65526264
146Deviation of the hallux (HP:0010051)1.64775424
147Hallux valgus (HP:0001822)1.64586837
148Fused cervical vertebrae (HP:0002949)1.63529573
149Viral hepatitis (HP:0006562)1.61855340
150Osteomyelitis (HP:0002754)1.60819360
151Abnormality of the acetabulum (HP:0003170)1.59747307
152Abnormality of the peritoneum (HP:0002585)1.57617112
153Flat acetabular roof (HP:0003180)1.57579959
154Recurrent gram-negative bacterial infections (HP:0005420)1.57327917
155Elbow flexion contracture (HP:0002987)1.57051478
156Bowed forearm bones (HP:0003956)1.56968212
157Bowing of the arm (HP:0006488)1.56968212
158Bladder diverticulum (HP:0000015)1.56951290
159Bruising susceptibility (HP:0000978)1.55634362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.77217781
2ERN13.72961733
3TRIB33.72054439
4MYLK3.45910473
5EEF2K3.15859384
6PKN23.15631882
7PIM22.26740318
8MAP3K102.24528019
9CDK122.18883597
10TTN2.09376550
11LRRK22.08209628
12TBK11.96138488
13PRPF4B1.91142024
14STK101.90985063
15PTK61.87666662
16ICK1.87082587
17BLK1.86422435
18RIPK11.84916083
19TGFBR21.79376166
20BMX1.73316688
21PAK41.69062645
22NME21.58274101
23RPS6KA41.52502829
24STK381.51248904
25TAOK31.46647594
26NTRK11.40915222
27BTK1.39865510
28CDK61.37900317
29MAP3K141.34770870
30MAP4K11.32169028
31PDGFRA1.31944277
32JAK31.31816933
33MAP3K61.31807776
34EPHB11.31413898
35TRPM71.30309630
36SIK11.29391603
37ZAP701.29196320
38MOS1.28798732
39TAOK21.28697586
40PIM11.26169797
41DMPK1.24197794
42MATK1.21854821
43TESK11.18581500
44KIT1.18140150
45MAP2K31.17913285
46CHUK1.14880877
47TYK21.13746509
48CDC42BPA1.13474971
49MAPK71.13455073
50PAK21.12426850
51MAPKAPK31.08664901
52IKBKB1.08566749
53PTK21.07969021
54FLT31.03763763
55MARK21.03714827
56SMG11.02916819
57RPS6KB21.02092365
58LIMK11.00455131
59SCYL20.98770665
60IKBKE0.94523476
61IRAK40.91525208
62DDR20.90363470
63TGFBR10.90174788
64ALK0.89442251
65IRAK30.88139227
66MTOR0.87350189
67EPHA20.85773084
68ABL20.85424397
69CSK0.85167248
70LATS10.84013725
71ILK0.83844283
72HCK0.83729787
73STK30.82445489
74CDK90.79696788
75CAMK1D0.79677845
76TAOK10.79124084
77TESK20.77815939
78CAMK1G0.76771999
79GRK70.76319541
80NEK90.75419264
81MAP3K110.75279456
82BRD40.72881558
83MAP2K10.72697849
84FGFR40.70747494
85MAP3K130.70409553
86DYRK1B0.70191032
87MAP3K80.69967081
88PRKG20.69395723
89KSR20.69371421
90PIK3CG0.69031313
91MAPKAPK20.68785111
92MAP3K10.67673539
93EPHA30.66905043
94MAP2K20.66647762
95PDPK10.66000520
96GSK3A0.65876007
97DAPK30.62161738
98NLK0.61584405
99NEK20.60619981
100RPS6KA60.60553980
101CDK40.60463444
102EPHB20.59459757
103WNK10.59365006
104MAP3K70.59275271
105CSF1R0.58921687
106RPS6KC10.56979072
107RPS6KL10.56979072
108PDGFRB0.56407083
109JAK10.56370635
110MAPK40.55221325
111PRKD10.55068848
112TEC0.54764733
113LATS20.52822239
114ROCK10.52429050
115HIPK20.51555382
116PRKD20.51511711
117PTK2B0.49997161
118CDK70.49513719
119ITK0.49300161
120PAK60.49222631
121STK40.48442428
122MAP3K50.47563741
123RPS6KA20.47386150
124MAP3K30.47076697
125MAPK120.46084893
126MELK0.44170490
127ERBB40.43647730
128ADRBK10.43342188
129SIK20.43253244
130RPS6KA10.41993421
131GRK60.41597454
132RET0.41064611
133PIK3CA0.40926249
134JAK20.40418092
135LCK0.39844907
136ROCK20.39797108
137ABL10.39729910
138PRKD30.39460453
139PAK10.37535086

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.34676919
2Osteoclast differentiation_Homo sapiens_hsa043801.95845322
3Chronic myeloid leukemia_Homo sapiens_hsa052201.91323031
4Toxoplasmosis_Homo sapiens_hsa051451.83017727
5Small cell lung cancer_Homo sapiens_hsa052221.82639660
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75034047
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.71585701
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.70012546
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.64028261
10Shigellosis_Homo sapiens_hsa051311.63975723
11Leukocyte transendothelial migration_Homo sapiens_hsa046701.62232137
12Acute myeloid leukemia_Homo sapiens_hsa052211.56284694
13Focal adhesion_Homo sapiens_hsa045101.56014681
14TNF signaling pathway_Homo sapiens_hsa046681.55770210
15Amoebiasis_Homo sapiens_hsa051461.54527613
16Legionellosis_Homo sapiens_hsa051341.53993410
17Proteoglycans in cancer_Homo sapiens_hsa052051.49123386
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.48482420
19Apoptosis_Homo sapiens_hsa042101.47813970
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.47570867
21Adherens junction_Homo sapiens_hsa045201.45801167
22Antigen processing and presentation_Homo sapiens_hsa046121.43717136
23Bladder cancer_Homo sapiens_hsa052191.43612935
24Protein digestion and absorption_Homo sapiens_hsa049741.42314020
25ECM-receptor interaction_Homo sapiens_hsa045121.41625593
26B cell receptor signaling pathway_Homo sapiens_hsa046621.41283249
27Pancreatic cancer_Homo sapiens_hsa052121.39229423
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38491338
29Measles_Homo sapiens_hsa051621.38187693
30Pertussis_Homo sapiens_hsa051331.37596571
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35784725
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35232448
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34930372
34Hepatitis B_Homo sapiens_hsa051611.33504960
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33255422
36Malaria_Homo sapiens_hsa051441.32033727
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31968836
38Platelet activation_Homo sapiens_hsa046111.31038390
39Salmonella infection_Homo sapiens_hsa051321.30014928
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28950064
41Viral myocarditis_Homo sapiens_hsa054161.27223344
42Tuberculosis_Homo sapiens_hsa051521.25360932
43Influenza A_Homo sapiens_hsa051641.22464504
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22411053
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22345561
46MicroRNAs in cancer_Homo sapiens_hsa052061.22074419
47p53 signaling pathway_Homo sapiens_hsa041151.21650840
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.14427585
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13832622
50Herpes simplex infection_Homo sapiens_hsa051681.11465166
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09129255
52Prion diseases_Homo sapiens_hsa050201.09118670
53Asthma_Homo sapiens_hsa053101.07473247
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.06788043
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.05440747
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04663970
57Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01424674
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99521145
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.99387944
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99077225
61Lysosome_Homo sapiens_hsa041420.98783721
62HIF-1 signaling pathway_Homo sapiens_hsa040660.98693449
63HTLV-I infection_Homo sapiens_hsa051660.98250777
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.97948660
65Colorectal cancer_Homo sapiens_hsa052100.96410866
66VEGF signaling pathway_Homo sapiens_hsa043700.94878271
67Hematopoietic cell lineage_Homo sapiens_hsa046400.94189961
68Notch signaling pathway_Homo sapiens_hsa043300.94103393
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93548097
70Prolactin signaling pathway_Homo sapiens_hsa049170.93118234
71GnRH signaling pathway_Homo sapiens_hsa049120.92863069
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92847605
73Non-small cell lung cancer_Homo sapiens_hsa052230.92646463
74TGF-beta signaling pathway_Homo sapiens_hsa043500.92487107
75Melanogenesis_Homo sapiens_hsa049160.91796059
76Other glycan degradation_Homo sapiens_hsa005110.91750688
77Thyroid cancer_Homo sapiens_hsa052160.91728060
78MAPK signaling pathway_Homo sapiens_hsa040100.89389328
79Chemokine signaling pathway_Homo sapiens_hsa040620.87618187
80Endometrial cancer_Homo sapiens_hsa052130.87016594
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.86574593
82mTOR signaling pathway_Homo sapiens_hsa041500.85748197
83Endocytosis_Homo sapiens_hsa041440.85207386
84Viral carcinogenesis_Homo sapiens_hsa052030.85020712
85Hedgehog signaling pathway_Homo sapiens_hsa043400.84789821
86Estrogen signaling pathway_Homo sapiens_hsa049150.84263745
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84044366
88Gap junction_Homo sapiens_hsa045400.83758354
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83682967
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83488675
91Renin-angiotensin system_Homo sapiens_hsa046140.82366624
92Pathways in cancer_Homo sapiens_hsa052000.81394616
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.81235917
94N-Glycan biosynthesis_Homo sapiens_hsa005100.80251968
95Hippo signaling pathway_Homo sapiens_hsa043900.78610809
96Insulin signaling pathway_Homo sapiens_hsa049100.78415733
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77709885
98Prostate cancer_Homo sapiens_hsa052150.77054756
99Phagosome_Homo sapiens_hsa041450.77001840
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76262767
101ErbB signaling pathway_Homo sapiens_hsa040120.76257808
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75106690
103FoxO signaling pathway_Homo sapiens_hsa040680.74904015
104Insulin resistance_Homo sapiens_hsa049310.73850885
105Basal cell carcinoma_Homo sapiens_hsa052170.73762657
106AMPK signaling pathway_Homo sapiens_hsa041520.73472182
107Inositol phosphate metabolism_Homo sapiens_hsa005620.70940180
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69562559
109Choline metabolism in cancer_Homo sapiens_hsa052310.68625088
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68582730
111Long-term potentiation_Homo sapiens_hsa047200.67932823
112Dorso-ventral axis formation_Homo sapiens_hsa043200.67426945
113Glioma_Homo sapiens_hsa052140.66285612
114Hepatitis C_Homo sapiens_hsa051600.65891851
115Renal cell carcinoma_Homo sapiens_hsa052110.64365265
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.64358784
117Staphylococcus aureus infection_Homo sapiens_hsa051500.63403473
118Ribosome_Homo sapiens_hsa030100.62705444
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.62392171
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61573609
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61441136
122Ras signaling pathway_Homo sapiens_hsa040140.61219949
123Dilated cardiomyopathy_Homo sapiens_hsa054140.60984944
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60752361
125Melanoma_Homo sapiens_hsa052180.60639564
126Rap1 signaling pathway_Homo sapiens_hsa040150.59327912
127Epstein-Barr virus infection_Homo sapiens_hsa051690.58223934
128Wnt signaling pathway_Homo sapiens_hsa043100.57146716
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56995937
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55415625
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55387028
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55112206
133Galactose metabolism_Homo sapiens_hsa000520.55021235
134Graft-versus-host disease_Homo sapiens_hsa053320.54879846

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