CITED4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heme biosynthetic process (GO:0006783)9.78493445
2porphyrin-containing compound biosynthetic process (GO:0006779)9.71477651
3tetrapyrrole biosynthetic process (GO:0033014)8.65146143
4heme metabolic process (GO:0042168)7.62000922
5porphyrin-containing compound metabolic process (GO:0006778)7.59905675
6granulocyte differentiation (GO:0030851)6.96827523
7erythrocyte maturation (GO:0043249)6.80646301
8embryonic hemopoiesis (GO:0035162)6.72905166
9erythrocyte development (GO:0048821)6.56327122
10platelet formation (GO:0030220)6.10876186
11desmosome organization (GO:0002934)5.75395393
12atrioventricular valve morphogenesis (GO:0003181)5.70109712
13CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.41795162
14hemidesmosome assembly (GO:0031581)5.18108301
15erythrocyte differentiation (GO:0030218)5.16080342
16regulation of erythrocyte differentiation (GO:0045646)5.06845924
17myeloid cell development (GO:0061515)5.03545410
18tetrapyrrole metabolic process (GO:0033013)4.99182862
19DNA deamination (GO:0045006)4.84934717
20heart valve formation (GO:0003188)4.76373446
21thyroid hormone generation (GO:0006590)4.72333628
22megakaryocyte development (GO:0035855)4.68026221
23response to lead ion (GO:0010288)4.64623895
24pigment biosynthetic process (GO:0046148)4.44741096
25negative regulation of erythrocyte differentiation (GO:0045647)4.34605018
26maternal placenta development (GO:0001893)4.26864371
27positive regulation of odontogenesis (GO:0042482)4.13687656
28viral transcription (GO:0019083)4.12812020
29cellular response to thyroid hormone stimulus (GO:0097067)4.08210976
30pinocytosis (GO:0006907)3.97820257
31translational termination (GO:0006415)3.93139304
32basement membrane organization (GO:0071711)3.92130672
33apoptotic process involved in morphogenesis (GO:0060561)3.92082705
34disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.89377029
35killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.89377029
36negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.89238034
37negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.86724214
38positive regulation of osteoblast proliferation (GO:0033690)3.79378477
39urea cycle (GO:0000050)3.77379594
40positive regulation of erythrocyte differentiation (GO:0045648)3.68994664
413-UTR-mediated mRNA stabilization (GO:0070935)3.66128678
42pigment metabolic process (GO:0042440)3.64429498
43positive regulation of histone deacetylation (GO:0031065)3.60513716
44thyroid hormone metabolic process (GO:0042403)3.57465473
45planar cell polarity pathway involved in neural tube closure (GO:0090179)3.56427073
46SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.56180911
47T cell lineage commitment (GO:0002360)3.55770133
48translational elongation (GO:0006414)3.55695058
49cell-substrate junction assembly (GO:0007044)3.54312392
50response to methylmercury (GO:0051597)3.52297107
51establishment of apical/basal cell polarity (GO:0035089)3.51819798
52regulation of water loss via skin (GO:0033561)3.49411750
53protein targeting to ER (GO:0045047)3.49342434
54urea metabolic process (GO:0019627)3.48902262
55ribosomal small subunit assembly (GO:0000028)3.46273595
56cotranslational protein targeting to membrane (GO:0006613)3.44018479
57purine-containing compound salvage (GO:0043101)3.38127696
58negative regulation of fatty acid transport (GO:2000192)3.35924311
59establishment of protein localization to endoplasmic reticulum (GO:0072599)3.33888471
60oxidative phosphorylation (GO:0006119)3.29341468
61response to thyroid hormone (GO:0097066)3.28646318
62UV protection (GO:0009650)3.26960009
63epithelial cell-cell adhesion (GO:0090136)3.26296408
64protein localization to endoplasmic reticulum (GO:0070972)3.24227462
65cell-cell junction maintenance (GO:0045217)3.24023309
66translational initiation (GO:0006413)3.23783809
67decidualization (GO:0046697)3.21707027
68viral life cycle (GO:0019058)3.20543485
69cell-substrate adherens junction assembly (GO:0007045)3.19021306
70focal adhesion assembly (GO:0048041)3.19021306
71endothelial cell chemotaxis (GO:0035767)3.17425127
72pattern specification involved in kidney development (GO:0061004)3.16933297
73regulation of apoptotic process involved in morphogenesis (GO:1902337)3.15953557
74regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.15847760
75establishment of skin barrier (GO:0061436)3.14299993
76protein autoprocessing (GO:0016540)3.14138332
77DNA strand elongation involved in DNA replication (GO:0006271)3.13394471
78protein localization to endosome (GO:0036010)3.13197951
79ribosomal small subunit biogenesis (GO:0042274)3.13053447
80negative regulation of bone mineralization (GO:0030502)3.11722886
81response to insecticide (GO:0017085)3.11361055
82negative regulation of cell size (GO:0045792)3.11358442
83nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.11056395
84DNA replication initiation (GO:0006270)3.07309217
85adherens junction assembly (GO:0034333)3.04528362
86telomere maintenance via semi-conservative replication (GO:0032201)3.04381828
87nitrogen cycle metabolic process (GO:0071941)3.03503313
88bundle of His cell to Purkinje myocyte communication (GO:0086069)3.01994992
89cellular protein complex disassembly (GO:0043624)3.01536083
90mannose metabolic process (GO:0006013)2.99817541
91DNA replication checkpoint (GO:0000076)2.99689496
92regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.97463595
93atrial septum morphogenesis (GO:0060413)2.97434798
94activation of Rac GTPase activity (GO:0032863)2.95800117
95positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.93224901
96angiogenesis involved in wound healing (GO:0060055)2.93170289
97regulation of response to osmotic stress (GO:0047484)2.91557457
98DNA strand elongation (GO:0022616)2.90752044
99positive regulation of protein deacetylation (GO:0090312)2.89932539
100one-carbon compound transport (GO:0019755)2.88348632
101proline biosynthetic process (GO:0006561)2.87599326
102embryonic process involved in female pregnancy (GO:0060136)2.86829972
103formation of translation preinitiation complex (GO:0001731)2.84954498
104negative regulation of granulocyte differentiation (GO:0030853)2.84903390
105proteasome assembly (GO:0043248)2.83272957
106pentose-phosphate shunt (GO:0006098)2.82142569
107negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.82069700
108negative regulation of interleukin-8 production (GO:0032717)2.81394412
109low-density lipoprotein particle clearance (GO:0034383)2.80949358
110GDP-mannose metabolic process (GO:0019673)2.80712591
111regulation of p38MAPK cascade (GO:1900744)2.80386540
112protein localization to chromosome, centromeric region (GO:0071459)2.78251226
113protein retention in ER lumen (GO:0006621)2.78231084
114cofactor biosynthetic process (GO:0051188)2.77927254
115regulation of cholesterol biosynthetic process (GO:0045540)2.76218597
116mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.75175431
117negative regulation of viral release from host cell (GO:1902187)2.74431662
118hydrogen peroxide catabolic process (GO:0042744)2.74226618
119negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73643044
120glucose catabolic process (GO:0006007)2.73524695
121iron ion import (GO:0097286)2.71345783
122protein complex disassembly (GO:0043241)2.71126438
123neutrophil mediated immunity (GO:0002446)2.70743130
124cellular response to dexamethasone stimulus (GO:0071549)2.69819978
125lysine catabolic process (GO:0006554)2.69776524
126lysine metabolic process (GO:0006553)2.69776524
127hemoglobin metabolic process (GO:0020027)2.69583988
128folic acid-containing compound biosynthetic process (GO:0009396)2.68968709
129vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.68707857
130positive regulation of fatty acid beta-oxidation (GO:0032000)2.68584308
131negative regulation of biomineral tissue development (GO:0070168)2.68581349
132positive regulation of fibroblast migration (GO:0010763)2.68553690
133lipopolysaccharide biosynthetic process (GO:0009103)2.67892559
134stress fiber assembly (GO:0043149)2.67667554
135establishment of monopolar cell polarity (GO:0061162)2.67243809
136establishment or maintenance of monopolar cell polarity (GO:0061339)2.67243809
137regulation of translational fidelity (GO:0006450)2.66569583
138negative regulation of RNA splicing (GO:0033119)2.66142878
139bicarbonate transport (GO:0015701)2.65321101
140positive regulation of Cdc42 GTPase activity (GO:0043089)2.63783284
141translation (GO:0006412)2.63425034
142gas transport (GO:0015669)2.63081850
143positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.62320986
144regulation of fatty acid beta-oxidation (GO:0031998)2.61396433
145citrulline biosynthetic process (GO:0019240)2.59593608
146negative regulation of transcription regulatory region DNA binding (GO:2000678)2.59105789
147maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.58873335
148hemopoiesis (GO:0030097)2.58794391
149semaphorin-plexin signaling pathway (GO:0071526)2.58416014
150regulation of exit from mitosis (GO:0007096)2.57151270
151apoptotic process involved in development (GO:1902742)2.54479931
152response to arsenic-containing substance (GO:0046685)2.53644570
153hyaluronan catabolic process (GO:0030214)2.52887545
154regulation of mammary gland epithelial cell proliferation (GO:0033599)2.52778840
155regulation of transcription regulatory region DNA binding (GO:2000677)2.52762583
156macromolecular complex disassembly (GO:0032984)2.51007877
157intracellular estrogen receptor signaling pathway (GO:0030520)2.50467860
158cell junction maintenance (GO:0034331)2.49289676
159response to peptidoglycan (GO:0032494)2.48919690
160hypotonic response (GO:0006971)2.48210058
161tooth mineralization (GO:0034505)2.45186624
162positive regulation of triglyceride metabolic process (GO:0090208)2.43299512
163response to laminar fluid shear stress (GO:0034616)2.43029310
164citrulline metabolic process (GO:0000052)2.42974903
165cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.42616995
166multicellular organismal water homeostasis (GO:0050891)2.42509440
167positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.41898870
168membrane tubulation (GO:0097320)2.39960973
169sperm capacitation (GO:0048240)2.39672282
170activation of MAPKKK activity (GO:0000185)2.38999058
171respiratory system process (GO:0003016)2.35911052
172negative regulation of catenin import into nucleus (GO:0035414)2.34857668
173positive regulation of lipid catabolic process (GO:0050996)2.34834744
174white fat cell differentiation (GO:0050872)2.33641546
175amyloid precursor protein catabolic process (GO:0042987)2.33527398
176glycogen catabolic process (GO:0005980)2.33200241
177glial cell migration (GO:0008347)2.32623426
178osteoblast development (GO:0002076)2.32011704
179cell volume homeostasis (GO:0006884)2.30769516
180mammary gland epithelial cell differentiation (GO:0060644)2.30403597
181cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.29872400
182embryonic skeletal joint morphogenesis (GO:0060272)2.28389380
183regulation of necrotic cell death (GO:0010939)2.26870837
184negative regulation of striated muscle cell differentiation (GO:0051154)2.26820108
185negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.25415877
186keratinization (GO:0031424)2.24831057
187barbed-end actin filament capping (GO:0051016)2.24517976
188dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.24283257
189protoporphyrinogen IX metabolic process (GO:0046501)11.4760718
190protoporphyrinogen IX biosynthetic process (GO:0006782)10.7005933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse5.06897033
2E2F7_22180533_ChIP-Seq_HELA_Human4.21783760
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.14021054
4GATA1_22025678_ChIP-Seq_K562_Human3.60036244
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.19513631
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.02623362
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.79798771
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.68334312
9SCL_19346495_ChIP-Seq_HPC-7_Human2.64733063
10MYC_22102868_ChIP-Seq_BL_Human2.61550381
11* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.56662987
12GATA1_19941826_ChIP-Seq_K562_Human2.45180110
13GATA1_19941827_ChIP-Seq_MEL_Mouse2.35493369
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.33932812
15* GATA1_22383799_ChIP-Seq_G1ME_Mouse2.23936652
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10547947
17TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.10487365
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.06018135
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05138132
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01434155
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.00053977
22* VDR_21846776_ChIP-Seq_THP-1_Human1.98859122
23ZNF263_19887448_ChIP-Seq_K562_Human1.92651505
24* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88244452
25* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.83308328
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81761931
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81306929
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80835540
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78725306
30KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.77741876
31SMC4_20622854_ChIP-Seq_HELA_Human1.77252279
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73944939
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.73565851
34XRN2_22483619_ChIP-Seq_HELA_Human1.71334764
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70097617
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68066124
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.67232424
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65332653
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64805336
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.64603327
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.62964764
42* KDM2B_26808549_Chip-Seq_K562_Human1.61697327
43* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60400327
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58217935
45CTCF_27219007_Chip-Seq_Bcells_Human1.56557683
46CREB1_26743006_Chip-Seq_LNCaP_Human1.56145235
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.55960281
48* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55286495
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.53681923
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51073405
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50459181
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.49377249
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48716909
54CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.48629141
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48018340
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47111477
57DCP1A_22483619_ChIP-Seq_HELA_Human1.46892901
58EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46011353
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45330082
60* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44254650
61CIITA_25753668_ChIP-Seq_RAJI_Human1.43495780
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42687457
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41734505
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.40203218
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39901451
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.39882672
67SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39869299
68* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39664569
69GABP_19822575_ChIP-Seq_HepG2_Human1.38327131
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36642934
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35730251
72VDR_23849224_ChIP-Seq_CD4+_Human1.34731141
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34631577
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.33463066
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33399189
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33137258
77MAF_26560356_Chip-Seq_TH1_Human1.32476815
78TCF7_22412390_ChIP-Seq_EML_Mouse1.32018971
79* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31985653
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.31862074
81LXR_22292898_ChIP-Seq_THP-1_Human1.31858243
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30893249
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30618995
84* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29789603
85KDM5A_27292631_Chip-Seq_BREAST_Human1.28896320
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28891946
87RXR_22158963_ChIP-Seq_LIVER_Mouse1.28647754
88ATF3_27146783_Chip-Seq_COLON_Human1.27556848
89NCOR1_26117541_ChIP-Seq_K562_Human1.27343893
90KDM2B_26808549_Chip-Seq_DND41_Human1.26449298
91TP63_22573176_ChIP-Seq_HFKS_Human1.26040347
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25792007
93* SA1_27219007_Chip-Seq_Bcells_Human1.25729961
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25137194
95MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.24883292
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24829476
97* GATA2_19941826_ChIP-Seq_K562_Human1.24521345
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.23774832
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22214677
100P68_20966046_ChIP-Seq_HELA_Human1.22193330
101FOXP3_21729870_ChIP-Seq_TREG_Human1.21751999
102FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21084433
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20916297
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20762117
105E2F1_20622854_ChIP-Seq_HELA_Human1.18101213
106MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17939409
107TP53_22127205_ChIP-Seq_IMR90_Human1.17700705
108RACK7_27058665_Chip-Seq_MCF-7_Human1.17503479
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16619314
110ESR1_21235772_ChIP-Seq_MCF-7_Human1.16268214
111PHF8_20622854_ChIP-Seq_HELA_Human1.16211934
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15720503
113UBF1/2_26484160_Chip-Seq_HMECs_Human1.15664596
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15089044
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14810254
116TTF2_22483619_ChIP-Seq_HELA_Human1.14421424
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14141673
118* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13361201
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12573852
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12489719
121CLOCK_20551151_ChIP-Seq_293T_Human1.12467395
122NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11859623
123YY1_22570637_ChIP-Seq_MALME-3M_Human1.11641165
124MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11450732
125TFEB_21752829_ChIP-Seq_HELA_Human1.11007628
126BCOR_27268052_Chip-Seq_Bcells_Human1.10614338
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10428630
128UTX_26944678_Chip-Seq_JUKART_Human1.09474832
129DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09128040
130ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09087625
131NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09070941
132* RUNX1_22412390_ChIP-Seq_EML_Mouse1.08969373
133CTCF_26484167_Chip-Seq_Bcells_Mouse1.08839186
134SA1_27219007_Chip-Seq_ERYTHROID_Human1.08723232
135STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.08112940
136KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08065267
137BCL6_27268052_Chip-Seq_Bcells_Human1.08033565
138NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07672252
139CTCF_21964334_Chip-Seq_Bcells_Human1.06462757
140MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04464724
141* MAF_26560356_Chip-Seq_TH2_Human1.04020489
142* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03797807
143RARA_24833708_ChIP-Seq_LIVER_Mouse1.03528925
144CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03250682
145E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01592029
146PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01447594
147SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01215371
148CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00221635
149KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99230223
150PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98456999
151VDR_24763502_ChIP-Seq_THP-1_Human0.98453613
152ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97958092
153SRF_21415370_ChIP-Seq_HL-1_Mouse0.97739945
154FOXP1_21924763_ChIP-Seq_HESCs_Human0.97344295
155BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97266395
156HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97107989
157* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96711381
158TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96674997
159RARB_24833708_ChIP-Seq_LIVER_Mouse0.96271133

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo8.98051133
2MP0004147_increased_porphyrin_level7.32203542
3MP0001545_abnormal_hematopoietic_system3.88048063
4MP0005397_hematopoietic_system_phenotyp3.88048063
5MP0005451_abnormal_body_composition3.42614372
6MP0005076_abnormal_cell_differentiation3.27373591
7MP0003111_abnormal_nucleus_morphology2.80999724
8MP0002132_abnormal_respiratory_system2.80042368
9MP0005083_abnormal_biliary_tract2.60546953
10MP0005058_abnormal_lysosome_morphology2.53951595
11MP0005670_abnormal_white_adipose2.48088893
12MP0000579_abnormal_nail_morphology2.47987256
13MP0006054_spinal_hemorrhage2.44421249
14MP0010030_abnormal_orbit_morphology2.35995283
15MP0005666_abnormal_adipose_tissue2.28686483
16MP0003693_abnormal_embryo_hatching2.25662696
17MP0000566_synostosis2.25398526
18MP0001849_ear_inflammation2.20574060
19MP0000751_myopathy2.16963553
20MP0005375_adipose_tissue_phenotype2.16934396
21MP0004381_abnormal_hair_follicle2.13480572
22MP0005409_darkened_coat_color2.10383033
23MP0000490_abnormal_crypts_of2.07817896
24MP0004957_abnormal_blastocyst_morpholog2.06815831
25MP0006036_abnormal_mitochondrial_physio2.06659878
26MP0008775_abnormal_heart_ventricle2.05523558
27MP0005636_abnormal_mineral_homeostasis1.96727582
28MP0004215_abnormal_myocardial_fiber1.89868911
29MP0008260_abnormal_autophagy1.89142102
30MP0010352_gastrointestinal_tract_polyps1.82504028
31MP0001348_abnormal_lacrimal_gland1.76349074
32MP0000467_abnormal_esophagus_morphology1.76022860
33MP0003300_gastrointestinal_ulcer1.75570904
34MP0009840_abnormal_foam_cell1.73225528
35MP0000749_muscle_degeneration1.69258726
36MP0003077_abnormal_cell_cycle1.68994973
37MP0002060_abnormal_skin_morphology1.65862633
38MP0002254_reproductive_system_inflammat1.64991816
39MP0002396_abnormal_hematopoietic_system1.64373185
40MP0005377_hearing/vestibular/ear_phenot1.61738847
41MP0003878_abnormal_ear_physiology1.61738847
42MP0002249_abnormal_larynx_morphology1.57110409
43MP0010094_abnormal_chromosome_stability1.54375901
44MP0001216_abnormal_epidermal_layer1.51973868
45MP0005501_abnormal_skin_physiology1.47263257
46MP0000013_abnormal_adipose_tissue1.45415963
47MP0003705_abnormal_hypodermis_morpholog1.44373426
48MP0005410_abnormal_fertilization1.43996888
49MP0005310_abnormal_salivary_gland1.42967599
50MP0005330_cardiomyopathy1.40396797
51MP0000733_abnormal_muscle_development1.35785414
52MP0000762_abnormal_tongue_morphology1.33330904
53MP0009931_abnormal_skin_appearance1.32591365
54MP0001661_extended_life_span1.30934137
55MP0009333_abnormal_splenocyte_physiolog1.28577526
56MP0006138_congestive_heart_failure1.27757435
57MP0008057_abnormal_DNA_replication1.25075389
58MP0009053_abnormal_anal_canal1.23185818
59MP0004858_abnormal_nervous_system1.21906770
60MP0009379_abnormal_foot_pigmentation1.21117138
61MP0004130_abnormal_muscle_cell1.19736402
62MP0008770_decreased_survivor_rate1.19656628
63MP0000313_abnormal_cell_death1.18922096
64MP0009278_abnormal_bone_marrow1.18805285
65MP0003866_abnormal_defecation1.18652988
66MP0004043_abnormal_pH_regulation1.16578663
67MP0002722_abnormal_immune_system1.16544917
68MP0003172_abnormal_lysosome_physiology1.16173715
69MP0004947_skin_inflammation1.15013373
70MP0002877_abnormal_melanocyte_morpholog1.14910302
71MP0005023_abnormal_wound_healing1.13301311
72MP0008872_abnormal_physiological_respon1.13007675
73MP0004084_abnormal_cardiac_muscle1.12573080
74MP0004264_abnormal_extraembryonic_tissu1.10990469
75MP0003091_abnormal_cell_migration1.10599602
76MP0003186_abnormal_redox_activity1.10551766
77MP0002398_abnormal_bone_marrow1.10500845
78MP0003806_abnormal_nucleotide_metabolis1.10396226
79MP0004233_abnormal_muscle_weight1.10125875
80MP0001730_embryonic_growth_arrest1.05783585
81MP0000858_altered_metastatic_potential1.04981737
82MP0001881_abnormal_mammary_gland1.04633976
83MP0000350_abnormal_cell_proliferation1.03599924
84MP0000689_abnormal_spleen_morphology1.02702345
85MP0000377_abnormal_hair_follicle1.02410362
86MP0002080_prenatal_lethality1.01662491
87MP0005360_urolithiasis1.00946863
88MP0002086_abnormal_extraembryonic_tissu0.97592843
89MP0003646_muscle_fatigue0.96771516
90MP0005275_abnormal_skin_tensile0.96332001
91MP0001697_abnormal_embryo_size0.95293714
92MP0002089_abnormal_postnatal_growth/wei0.93393969
93MP0000465_gastrointestinal_hemorrhage0.93213448
94MP0004510_myositis0.92276256
95MP0010234_abnormal_vibrissa_follicle0.90658809
96MP0001346_abnormal_lacrimal_gland0.90046941
97MP0002971_abnormal_brown_adipose0.89788360
98MP0002796_impaired_skin_barrier0.87349628
99MP0002019_abnormal_tumor_incidence0.87223839
100MP0002269_muscular_atrophy0.87218613
101MP0000750_abnormal_muscle_regeneration0.86621643
102MP0010307_abnormal_tumor_latency0.84333890
103MP0002429_abnormal_blood_cell0.83872440
104MP0000747_muscle_weakness0.83693582
105MP0006035_abnormal_mitochondrial_morpho0.83674565
106MP0001873_stomach_inflammation0.83293859
107MP0000685_abnormal_immune_system0.79749237
108MP0000678_abnormal_parathyroid_gland0.79728603
109MP0002098_abnormal_vibrissa_morphology0.79009316
110MP0000681_abnormal_thyroid_gland0.78823886
111MP0008007_abnormal_cellular_replicative0.78783190
112MP0003453_abnormal_keratinocyte_physiol0.77761322
113MP0010630_abnormal_cardiac_muscle0.77183447
114MP0000470_abnormal_stomach_morphology0.77163223
115MP0004782_abnormal_surfactant_physiolog0.76484996
116MP0002933_joint_inflammation0.76235937
117MP0002837_dystrophic_cardiac_calcinosis0.75675858
118MP0003436_decreased_susceptibility_to0.75560060
119MP0004036_abnormal_muscle_relaxation0.74473432
120MP0002970_abnormal_white_adipose0.73628679
121MP0008058_abnormal_DNA_repair0.73249794
122MP0000266_abnormal_heart_morphology0.72898258
123MP0000358_abnormal_cell_content/0.72874719
124MP0004087_abnormal_muscle_fiber0.72784003
125MP0000598_abnormal_liver_morphology0.72557576
126MP0003191_abnormal_cellular_cholesterol0.71892398
127MP0000609_abnormal_liver_physiology0.71503855
128MP0005623_abnormal_meninges_morphology0.71304113
129MP0000537_abnormal_urethra_morphology0.71290830
130MP0003984_embryonic_growth_retardation0.70909587
131MP0000703_abnormal_thymus_morphology0.70743879
132MP0008932_abnormal_embryonic_tissue0.70048415
133MP0005334_abnormal_fat_pad0.69786254
134MP0002088_abnormal_embryonic_growth/wei0.69476290
135MP0003828_pulmonary_edema0.69183549
136MP0000003_abnormal_adipose_tissue0.69025094
137MP0003137_abnormal_impulse_conducting0.68741972
138MP0009384_cardiac_valve_regurgitation0.68049026
139MP0004185_abnormal_adipocyte_glucose0.67779224
140MP0003566_abnormal_cell_adhesion0.66939607
141MP0000767_abnormal_smooth_muscle0.66831875
142MP0001340_abnormal_eyelid_morphology0.66755815
143MP0003221_abnormal_cardiomyocyte_apopto0.66420261
144MP0001672_abnormal_embryogenesis/_devel0.65607885
145MP0005380_embryogenesis_phenotype0.65607885
146MP0000367_abnormal_coat/_hair0.65071625
147MP0005248_abnormal_Harderian_gland0.63828289
148MP0002106_abnormal_muscle_physiology0.63160220
149MP0001851_eye_inflammation0.62984015
150MP0005075_abnormal_melanosome_morpholog0.62822458
151MP0003786_premature_aging0.62403118
152MP0001765_abnormal_ion_homeostasis0.61922425
153MP0005464_abnormal_platelet_physiology0.61516460
154MP0005319_abnormal_enzyme/_coenzyme0.61351586
155MP0010329_abnormal_lipoprotein_level0.60832128
156MP0003879_abnormal_hair_cell0.60640496
157MP0001663_abnormal_digestive_system0.59358565
158MP0000759_abnormal_skeletal_muscle0.59338238
159MP0001784_abnormal_fluid_regulation0.58581624
160MP0002972_abnormal_cardiac_muscle0.57721754
161MP0009643_abnormal_urine_homeostasis0.57536590
162MP0002653_abnormal_ependyma_morphology0.57387252
163MP0000627_abnormal_mammary_gland0.57321268
164MP0000249_abnormal_blood_vessel0.56939844
165MP0002998_abnormal_bone_remodeling0.56828070
166MP0010771_integument_phenotype0.56002998
167MP0002405_respiratory_system_inflammati0.55838123

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytosis (HP:0001923)8.54532036
2Poikilocytosis (HP:0004447)8.31960850
3Acanthocytosis (HP:0001927)7.82570809
4Abnormal number of erythroid precursors (HP:0012131)6.97948495
5Abnormality of cells of the erythroid lineage (HP:0012130)6.55231485
6Abnormality of reticulocytes (HP:0004312)6.16129323
7Petechiae (HP:0000967)5.69399511
8Polycythemia (HP:0001901)5.64554813
9Diaphragmatic weakness (HP:0009113)5.07204196
10Short middle phalanx of the 5th finger (HP:0004220)5.00116901
11Distal lower limb muscle weakness (HP:0009053)4.39955536
12Hyperbilirubinemia (HP:0002904)4.35242763
13Increased serum ferritin (HP:0003281)3.99179056
14Paralysis (HP:0003470)3.86770150
15Cholelithiasis (HP:0001081)3.78182569
16Pili torti (HP:0003777)3.76590770
17Vitreoretinal degeneration (HP:0000655)3.66114490
18Increased connective tissue (HP:0009025)3.65905929
19Pallor (HP:0000980)3.60418885
20Flattened epiphyses (HP:0003071)3.50444239
21Prolonged bleeding time (HP:0003010)3.48362330
22Abnormal gallbladder morphology (HP:0012437)3.32599972
23Distal lower limb amyotrophy (HP:0008944)3.26367752
24Abnormality of iron homeostasis (HP:0011031)3.22843093
25Obstructive sleep apnea (HP:0002870)3.14538187
26Fragile nails (HP:0001808)3.11063668
27Abnormality of transition element cation homeostasis (HP:0011030)3.06865125
28Milia (HP:0001056)3.03605915
29Myopathic facies (HP:0002058)3.02508067
30Abnormality of nail color (HP:0100643)3.02234277
31Asymmetric septal hypertrophy (HP:0001670)3.02035932
32Ulnar bowing (HP:0003031)2.99319017
33Insomnia (HP:0100785)2.93465019
34Stridor (HP:0010307)2.92922331
35Exercise-induced myalgia (HP:0003738)2.91515472
36Abnormal platelet function (HP:0011869)2.87236818
37Impaired platelet aggregation (HP:0003540)2.87236818
38Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.85256205
39Broad palm (HP:0001169)2.84048061
40Cutaneous photosensitivity (HP:0000992)2.83160582
41Abnormality of dental color (HP:0011073)2.81069985
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.66773986
43Bulbar palsy (HP:0001283)2.64972794
44Short 5th finger (HP:0009237)2.64785671
45Macrocytic anemia (HP:0001972)2.64329805
46Short nail (HP:0001799)2.63172740
47Onycholysis (HP:0001806)2.60449683
48Acanthosis nigricans (HP:0000956)2.60274654
49Brushfield spots (HP:0001088)2.57118318
50Natal tooth (HP:0000695)2.54578589
51Birth length less than 3rd percentile (HP:0003561)2.54356190
52Cerebral aneurysm (HP:0004944)2.54350145
53Abnormal hair laboratory examination (HP:0003328)2.53311563
54Cervical subluxation (HP:0003308)2.51623662
55Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.51085409
56Broad face (HP:0000283)2.51061410
57Ileus (HP:0002595)2.47782049
58Centrally nucleated skeletal muscle fibers (HP:0003687)2.45666132
59Type 1 muscle fiber predominance (HP:0003803)2.38941278
60Hypochromic anemia (HP:0001931)2.38294781
61Increased cerebral lipofuscin (HP:0011813)2.37496954
62Abnormality of the distal phalanges of the toes (HP:0010182)2.35815362
63Abnormal gallbladder physiology (HP:0012438)2.35601134
64Cholecystitis (HP:0001082)2.35601134
65Atrophic scars (HP:0001075)2.35513681
66Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.34950216
67Advanced eruption of teeth (HP:0006288)2.33764575
68Progressive muscle weakness (HP:0003323)2.32033302
69Abnormality of the Achilles tendon (HP:0005109)2.31430012
70Thick nail (HP:0001805)2.31375723
71Pustule (HP:0200039)2.31224747
72Alopecia of scalp (HP:0002293)2.30741681
73Epiphyseal dysplasia (HP:0002656)2.29774904
74Lip pit (HP:0100267)2.27233219
75Abnormality of skeletal muscle fiber size (HP:0012084)2.26150014
76Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25852619
77Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25852619
78Increased variability in muscle fiber diameter (HP:0003557)2.25261371
79Osteomalacia (HP:0002749)2.23547109
80Flat acetabular roof (HP:0003180)2.23300445
81Microcytic anemia (HP:0001935)2.22571057
82Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.21897320
83Upper limb amyotrophy (HP:0009129)2.20022074
84Distal upper limb amyotrophy (HP:0007149)2.20022074
85Multiple enchondromatosis (HP:0005701)2.19807883
86Mildly elevated creatine phosphokinase (HP:0008180)2.19229720
87Plantar hyperkeratosis (HP:0007556)2.18797644
88Epistaxis (HP:0000421)2.18023288
89Hypochromic microcytic anemia (HP:0004840)2.17857174
90Increased density of long bones (HP:0006392)2.17224159
91Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14535460
92Deep venous thrombosis (HP:0002625)2.14481345
93Turricephaly (HP:0000262)2.14044272
94Elbow flexion contracture (HP:0002987)2.13805724
95Abnormality of the gallbladder (HP:0005264)2.11783443
96Muscle fiber splitting (HP:0003555)2.11407069
97Joint stiffness (HP:0001387)2.11400195
98Hyponatremia (HP:0002902)2.09607296
99Abnormal blistering of the skin (HP:0008066)2.08896929
100Premature rupture of membranes (HP:0001788)2.08053009
101Nail dystrophy (HP:0008404)2.07402610
102Nasolacrimal duct obstruction (HP:0000579)2.06485812
103Easy fatigability (HP:0003388)2.04819842
104Axonal loss (HP:0003447)2.04560103
105Spinal rigidity (HP:0003306)2.03521880
106Thin bony cortex (HP:0002753)2.02249035
107Hyporeflexia of lower limbs (HP:0002600)2.01592528
108Hypertriglyceridemia (HP:0002155)2.00188324
109Abnormality of the heme biosynthetic pathway (HP:0010472)13.8574871
110Abnormality of monocarboxylic acid metabolism (HP:0010996)1.99880536
111Vertebral compression fractures (HP:0002953)1.98805126
112Hyperparathyroidism (HP:0000843)1.98033987
113Muscle fiber inclusion bodies (HP:0100299)1.97935464
114Ureteral duplication (HP:0000073)1.97673098
115Abnormality of the phalanges of the 5th finger (HP:0004213)1.97133702
116Down-sloping shoulders (HP:0200021)1.96433520
117Goiter (HP:0000853)1.96316537
118Protrusio acetabuli (HP:0003179)1.94902466
119Ulnar deviation of the wrist (HP:0003049)1.94729056
120Ventricular tachycardia (HP:0004756)1.94593768
121Fragile skin (HP:0001030)1.94201306
122Reticulocytopenia (HP:0001896)1.92302279
123Nemaline bodies (HP:0003798)1.91318774
124Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.88437094
125Generalized hyperpigmentation (HP:0007440)1.87953407
126Cortical visual impairment (HP:0100704)1.87416460
127Round ear (HP:0100830)1.86883034
128Metaphyseal cupping (HP:0003021)1.85464137
129Flared metaphyses (HP:0003015)1.84766003
130Sudden death (HP:0001699)1.84712310
131Abnormality of the thoracic spine (HP:0100711)1.83908202
132Bell-shaped thorax (HP:0001591)1.82937589
133Lymphangioma (HP:0100764)1.79276232
134Hypotrichosis (HP:0001006)1.78596943
135Hyperacusis (HP:0010780)1.77962742
136Ridged nail (HP:0001807)1.77381687
137Hemorrhage of the eye (HP:0011885)1.77360449
138Sparse lateral eyebrow (HP:0005338)1.75950940
139Lower limb amyotrophy (HP:0007210)1.75644615
140Increased IgE level (HP:0003212)1.75221708
141Testicular atrophy (HP:0000029)1.74815026
142Pterygium (HP:0001059)1.74799970
143Increased muscle lipid content (HP:0009058)1.74391249
144Waddling gait (HP:0002515)1.72275324
145Hypercortisolism (HP:0001578)1.70587990
146Ragged-red muscle fibers (HP:0003200)1.70187928
147Abnormal mitochondria in muscle tissue (HP:0008316)1.69313620
148Basal cell carcinoma (HP:0002671)1.69009070
149Abnormality of sodium homeostasis (HP:0010931)1.68281472
150Microretrognathia (HP:0000308)1.68141765
151Shallow orbits (HP:0000586)1.67627571
152Severe Myopia (HP:0011003)1.67387702
153Polygenic inheritance (HP:0010982)1.66897851
154Hepatic necrosis (HP:0002605)1.66386682
155Thin ribs (HP:0000883)1.66150339
156Hypoplasia of dental enamel (HP:0006297)1.65887444
157Breast hypoplasia (HP:0003187)1.65310952
158Myoglobinuria (HP:0002913)1.64067721
159Nausea (HP:0002018)1.63244153
160Increased intramyocellular lipid droplets (HP:0012240)1.62465239
161Acute necrotizing encephalopathy (HP:0006965)1.60294001
162Trismus (HP:0000211)1.59152597
163Hepatocellular necrosis (HP:0001404)1.58741874
164Selective tooth agenesis (HP:0001592)1.58086196
165Difficulty climbing stairs (HP:0003551)1.56476915
166Right ventricular cardiomyopathy (HP:0011663)1.55328084
167Mitochondrial inheritance (HP:0001427)1.55020339
168Global brain atrophy (HP:0002283)1.50593277
169Decreased subcutaneous fat (HP:0001002)1.50327054
170Hypoplasia of the pons (HP:0012110)1.46201610
171Generalized amyotrophy (HP:0003700)1.45639264
172Slender build (HP:0001533)1.45488237
173Rhabdomyolysis (HP:0003201)1.45398634
174Multiple lipomas (HP:0001012)1.45134636
175Increased serum lactate (HP:0002151)1.43923729
176Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.43633533
177Duodenal stenosis (HP:0100867)1.42878146
178Small intestinal stenosis (HP:0012848)1.42878146
179Hypoplastic iliac wings (HP:0002866)1.41444163
180Protruding tongue (HP:0010808)1.40899757
181Delusions (HP:0000746)1.39579985
182Achilles tendon contracture (HP:0001771)1.39570119
183Aplastic anemia (HP:0001915)1.39142773
184Secondary amenorrhea (HP:0000869)1.37103074
185Cerebral palsy (HP:0100021)1.36478314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.30810069
2EPHA24.26457992
3NME24.04975674
4MAP3K103.47375038
5TRIB33.06916835
6MAP3K112.89053914
7MST1R2.73870026
8SCYL22.41164091
9PKN22.39237880
10TESK12.28163266
11DYRK32.27146467
12BUB12.14059508
13ERN12.12640089
14MAPK152.07560610
15SMG12.06898542
16TAOK12.04516443
17EEF2K2.02973099
18RIPK11.95219255
19SIK11.93804923
20CDC71.92791851
21TAOK31.74750284
22CDK191.74375197
23PDK21.68874493
24MAPK111.62117674
25BCKDK1.60362212
26ICK1.57579833
27NEK21.57107990
28DYRK1B1.54099867
29BRSK11.53976746
30STK41.52879585
31PRPF4B1.52251559
32MAPKAPK31.51289680
33MAP4K11.50707960
34PIM21.48753225
35STK101.45453147
36KDR1.41416897
37RPS6KB21.30226864
38MARK21.22456461
39FLT31.21435917
40LRRK21.19439879
41PDPK11.19285104
42NEK11.16868041
43TLK11.16690411
44AURKA1.15823243
45BMX1.14786842
46MAP3K81.13273042
47MET1.06064286
48JAK21.04432685
49MAP2K21.03854661
50TNK21.03587215
51DMPK1.02468127
52MUSK1.02155306
53EPHB11.01417516
54PIM10.99212929
55PTK60.98604041
56CDK40.98461546
57PRKD30.98213758
58IRAK30.98060471
59BRSK20.97426383
60WEE10.94061443
61RPS6KA40.93968344
62RPS6KL10.92237442
63RPS6KC10.92237442
64RPS6KA60.91431577
65ABL20.90860896
66STK390.90080950
67PTK20.90031269
68GRK60.89801145
69HIPK20.87757761
70LATS20.86475602
71NME10.86259267
72EPHB20.85532417
73BRAF0.84460155
74ARAF0.82961913
75DDR20.82166793
76PAK40.81657786
77MAPK70.80564743
78RPS6KA10.80521242
79TAOK20.78390959
80CDK70.77778355
81MAP3K70.75964430
82STK380.75499389
83CDK120.74811241
84AURKB0.74551756
85MAP3K60.73387927
86MAPKAPK50.73276971
87VRK10.70486571
88OBSCN0.65968992
89PLK10.65702873
90PRKCI0.65200849
91CHEK20.63958520
92TRPM70.63299924
93MAP3K10.63208924
94PHKG10.63206616
95PHKG20.63206616
96RPS6KA20.61466055
97CDK60.61245238
98TBK10.60962886
99TTK0.60141353
100AKT20.58109771
101MATK0.57839335
102TTN0.57609022
103IKBKB0.57193649
104TYK20.55335550
105ILK0.55233321
106PDK10.55210537
107NTRK10.55089351
108MAPKAPK20.54627415
109MAP2K30.54250138
110UHMK10.53339802
111RIPK40.52172222
112IRAK40.51613906
113DAPK30.51408296
114PRKG20.51053865
115MAP3K130.50350215
116MAP2K60.49745810
117FGFR40.49286100
118MTOR0.49248370
119MAPK120.48454858
120MST40.48331948
121MAPK40.46440303
122CDC42BPA0.45316452
123ZAP700.45022346
124CDK80.43302702
125SIK20.43167246
126CHEK10.43105246
127WNK40.42750281
128CSNK2A20.42518943
129TGFBR20.41978530
130IRAK20.41882166
131STK160.41457896
132DAPK20.40862286
133RET0.40373566
134NEK60.39911221
135PIK3CG0.39146526
136TESK20.38982222
137MAP3K30.38834915
138RPS6KA50.37822211
139PRKAA20.37419483
140LMTK20.37114668
141GSK3A0.37078801
142PRKAA10.36186366
143BLK0.35556347
144PAK20.35506241
145ATM0.35047240
146PRKD20.34767494
147MAPK80.34411766
148PRKD10.33974419

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008605.77764249
2DNA replication_Homo sapiens_hsa030304.06131385
3Ribosome_Homo sapiens_hsa030104.01575803
4Phenylalanine metabolism_Homo sapiens_hsa003602.95632114
5Sulfur relay system_Homo sapiens_hsa041222.89513358
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.67463440
7Other glycan degradation_Homo sapiens_hsa005112.44717497
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.36492309
9Mismatch repair_Homo sapiens_hsa034302.34400839
10Parkinsons disease_Homo sapiens_hsa050122.32247430
11Spliceosome_Homo sapiens_hsa030402.25129808
12Base excision repair_Homo sapiens_hsa034102.22307942
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.22220925
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.17687555
15Oxidative phosphorylation_Homo sapiens_hsa001902.15048587
16Arginine biosynthesis_Homo sapiens_hsa002201.83566400
17Cell cycle_Homo sapiens_hsa041101.82226805
18Bladder cancer_Homo sapiens_hsa052191.81664406
19Nucleotide excision repair_Homo sapiens_hsa034201.72062637
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.72005875
21ECM-receptor interaction_Homo sapiens_hsa045121.66661123
22Huntingtons disease_Homo sapiens_hsa050161.61246717
23Vitamin B6 metabolism_Homo sapiens_hsa007501.58569038
24Pentose phosphate pathway_Homo sapiens_hsa000301.57989960
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56819521
26p53 signaling pathway_Homo sapiens_hsa041151.53078513
27Cardiac muscle contraction_Homo sapiens_hsa042601.52258972
28RNA transport_Homo sapiens_hsa030131.49774265
29Pyrimidine metabolism_Homo sapiens_hsa002401.36068666
30Alzheimers disease_Homo sapiens_hsa050101.34157355
31Homologous recombination_Homo sapiens_hsa034401.33798136
32Focal adhesion_Homo sapiens_hsa045101.31174054
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.30886983
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29810633
35Amoebiasis_Homo sapiens_hsa051461.28197501
36Tyrosine metabolism_Homo sapiens_hsa003501.25119988
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21937453
38Chronic myeloid leukemia_Homo sapiens_hsa052201.20911019
39Proteasome_Homo sapiens_hsa030501.18087647
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15716365
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13791371
42Caffeine metabolism_Homo sapiens_hsa002321.12309302
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11464527
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10748467
45Galactose metabolism_Homo sapiens_hsa000521.05846008
46Thyroid cancer_Homo sapiens_hsa052161.05817234
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.05615376
48Glycerophospholipid metabolism_Homo sapiens_hsa005641.05492498
49Acute myeloid leukemia_Homo sapiens_hsa052211.04922240
50One carbon pool by folate_Homo sapiens_hsa006701.04047375
51Carbon metabolism_Homo sapiens_hsa012001.03771591
52Pyruvate metabolism_Homo sapiens_hsa006201.01739729
53Protein export_Homo sapiens_hsa030601.01231883
54Folate biosynthesis_Homo sapiens_hsa007900.99594652
55Lysosome_Homo sapiens_hsa041420.98832851
56Selenocompound metabolism_Homo sapiens_hsa004500.97467348
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95440964
58mRNA surveillance pathway_Homo sapiens_hsa030150.94704454
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94609750
60RNA degradation_Homo sapiens_hsa030180.93137225
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92999638
62RNA polymerase_Homo sapiens_hsa030200.92590620
63ABC transporters_Homo sapiens_hsa020100.91890364
64Small cell lung cancer_Homo sapiens_hsa052220.90666539
65Biosynthesis of amino acids_Homo sapiens_hsa012300.90483978
66Dilated cardiomyopathy_Homo sapiens_hsa054140.90371814
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.90215547
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86483526
69Hepatitis C_Homo sapiens_hsa051600.85717725
70Systemic lupus erythematosus_Homo sapiens_hsa053220.84780953
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.81124036
72Endometrial cancer_Homo sapiens_hsa052130.80752751
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79557931
74PPAR signaling pathway_Homo sapiens_hsa033200.79062710
75Endocytosis_Homo sapiens_hsa041440.77950947
76Renal cell carcinoma_Homo sapiens_hsa052110.77826814
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77816865
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.77265550
79Complement and coagulation cascades_Homo sapiens_hsa046100.77097233
80Apoptosis_Homo sapiens_hsa042100.74646636
81Prion diseases_Homo sapiens_hsa050200.74611009
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72645191
83Non-small cell lung cancer_Homo sapiens_hsa052230.70251995
84Histidine metabolism_Homo sapiens_hsa003400.69659407
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.69604151
86AMPK signaling pathway_Homo sapiens_hsa041520.69119761
87Lysine degradation_Homo sapiens_hsa003100.68586775
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68585151
89Renin-angiotensin system_Homo sapiens_hsa046140.68566263
90GnRH signaling pathway_Homo sapiens_hsa049120.67515497
91Fructose and mannose metabolism_Homo sapiens_hsa000510.67417397
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67243790
93Pancreatic cancer_Homo sapiens_hsa052120.66874010
94ErbB signaling pathway_Homo sapiens_hsa040120.66051205
95Osteoclast differentiation_Homo sapiens_hsa043800.63687919
96TNF signaling pathway_Homo sapiens_hsa046680.62682169
97Insulin resistance_Homo sapiens_hsa049310.61900152
98Proteoglycans in cancer_Homo sapiens_hsa052050.61872567
99Glucagon signaling pathway_Homo sapiens_hsa049220.61037644
100Purine metabolism_Homo sapiens_hsa002300.60778760
101Insulin signaling pathway_Homo sapiens_hsa049100.58909412
102Fanconi anemia pathway_Homo sapiens_hsa034600.58866602
103Fatty acid metabolism_Homo sapiens_hsa012120.58825509
104Glutathione metabolism_Homo sapiens_hsa004800.58683947
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58115188
106Hematopoietic cell lineage_Homo sapiens_hsa046400.58021146
107Tight junction_Homo sapiens_hsa045300.56800352
108VEGF signaling pathway_Homo sapiens_hsa043700.56368242
109Arginine and proline metabolism_Homo sapiens_hsa003300.55622697
110Fatty acid biosynthesis_Homo sapiens_hsa000610.55306043
111Bile secretion_Homo sapiens_hsa049760.55157838
112Herpes simplex infection_Homo sapiens_hsa051680.54674388
113Basal cell carcinoma_Homo sapiens_hsa052170.54487371
114Hepatitis B_Homo sapiens_hsa051610.54226522
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52524285
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52211638
117HTLV-I infection_Homo sapiens_hsa051660.50864807
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50270901
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.50234950
120Fat digestion and absorption_Homo sapiens_hsa049750.50124851
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49461959
122Choline metabolism in cancer_Homo sapiens_hsa052310.49138632
123Glioma_Homo sapiens_hsa052140.49113419
124Autoimmune thyroid disease_Homo sapiens_hsa053200.48731100
125Inositol phosphate metabolism_Homo sapiens_hsa005620.48655178
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47602332
127mTOR signaling pathway_Homo sapiens_hsa041500.46247135
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.45942206
129Influenza A_Homo sapiens_hsa051640.44967555
130Antigen processing and presentation_Homo sapiens_hsa046120.44393103
131B cell receptor signaling pathway_Homo sapiens_hsa046620.43872810
132FoxO signaling pathway_Homo sapiens_hsa040680.42512338
133N-Glycan biosynthesis_Homo sapiens_hsa005100.42303398
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.41638783
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40971702
136Prolactin signaling pathway_Homo sapiens_hsa049170.40828455
137Viral carcinogenesis_Homo sapiens_hsa052030.40689768
138MAPK signaling pathway_Homo sapiens_hsa040100.40194696
139Metabolic pathways_Homo sapiens_hsa011000.40080891
140Pertussis_Homo sapiens_hsa051330.39506011
141Cyanoamino acid metabolism_Homo sapiens_hsa004600.37770297
142Linoleic acid metabolism_Homo sapiens_hsa005910.36991022
143Toxoplasmosis_Homo sapiens_hsa051450.36735536
144Measles_Homo sapiens_hsa051620.34530914
145Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33925017
146Non-homologous end-joining_Homo sapiens_hsa034500.32299909
147HIF-1 signaling pathway_Homo sapiens_hsa040660.31992397
148Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30624378
149Thyroid hormone synthesis_Homo sapiens_hsa049180.30009268
150Epstein-Barr virus infection_Homo sapiens_hsa051690.29497966
151Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29135435
152Fatty acid degradation_Homo sapiens_hsa000710.28551920
153Notch signaling pathway_Homo sapiens_hsa043300.27033101
154Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.26480573
155Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25429293
156Alcoholism_Homo sapiens_hsa050340.23527044
157Jak-STAT signaling pathway_Homo sapiens_hsa046300.21895738

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