CIZ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)8.75214108
2N-glycan processing (GO:0006491)5.60858714
3regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)5.48823496
4positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)5.48823496
5regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)5.47407832
6positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO5.47407832
7positive regulation of gamma-delta T cell activation (GO:0046645)5.20839883
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.10522891
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.10522891
10positive regulation of mRNA catabolic process (GO:0061014)4.97821265
11regulation of mRNA catabolic process (GO:0061013)4.67620450
12antigen processing and presentation of endogenous antigen (GO:0019883)4.65283215
13COPI coating of Golgi vesicle (GO:0048205)4.44786929
14Golgi transport vesicle coating (GO:0048200)4.44786929
15synaptic vesicle endocytosis (GO:0048488)4.41407928
16antigen processing and presentation via MHC class Ib (GO:0002475)4.41203692
17regulation of histone H3-K27 methylation (GO:0061085)4.33545012
18RNA localization (GO:0006403)4.16040337
19negative regulation of cell size (GO:0045792)4.10901637
20DNA unwinding involved in DNA replication (GO:0006268)4.10184096
21regulation of early endosome to late endosome transport (GO:2000641)4.06859421
22negative regulation of erythrocyte differentiation (GO:0045647)4.06794936
23regulation of translational fidelity (GO:0006450)4.02029435
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.01024597
25protein retention in ER lumen (GO:0006621)4.00649099
26regulation of gamma-delta T cell activation (GO:0046643)3.98592897
27regulation of gamma-delta T cell differentiation (GO:0045586)3.88053954
28proline biosynthetic process (GO:0006561)3.87970007
29regulation of RNA export from nucleus (GO:0046831)3.86929839
30positive regulation of histone deacetylation (GO:0031065)3.86570533
31regulation of mammary gland epithelial cell proliferation (GO:0033599)3.78240244
32regulation of nucleobase-containing compound transport (GO:0032239)3.65764868
33spliceosomal tri-snRNP complex assembly (GO:0000244)3.63834016
34mitotic chromosome condensation (GO:0007076)3.56335925
35retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.52578364
36adherens junction assembly (GO:0034333)3.52493925
37cell-substrate adherens junction assembly (GO:0007045)3.51521105
38focal adhesion assembly (GO:0048041)3.51521105
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.47150640
40histone H3-K4 trimethylation (GO:0080182)3.46295934
41positive thymic T cell selection (GO:0045059)3.45112756
42regulation of glucose import in response to insulin stimulus (GO:2001273)3.34132739
43intracellular estrogen receptor signaling pathway (GO:0030520)3.30546840
44regulation of interleukin-12 biosynthetic process (GO:0045075)3.29328334
45cytoskeletal anchoring at plasma membrane (GO:0007016)3.28994237
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.27929873
47negative regulation of granulocyte differentiation (GO:0030853)3.27510207
48glucose 6-phosphate metabolic process (GO:0051156)3.25703560
49planar cell polarity pathway involved in neural tube closure (GO:0090179)3.23806634
50protein-DNA complex disassembly (GO:0032986)3.20766505
51nucleosome disassembly (GO:0006337)3.20766505
52mannose metabolic process (GO:0006013)3.18094866
53positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.15826720
54activation of Rac GTPase activity (GO:0032863)3.15493215
55positive regulation of protein deacetylation (GO:0090312)3.13965608
56negative thymic T cell selection (GO:0045060)3.13811485
57mitotic sister chromatid cohesion (GO:0007064)3.13777745
58maternal placenta development (GO:0001893)3.13727243
59nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.12534589
60regulation of B cell receptor signaling pathway (GO:0050855)3.11403716
61apoptotic process involved in morphogenesis (GO:0060561)3.11376461
62positive regulation of mRNA 3-end processing (GO:0031442)3.10865630
63activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.08835153
64positive regulation of B cell differentiation (GO:0045579)3.08492522
65cardiolipin metabolic process (GO:0032048)3.05923414
66regulation of erythrocyte differentiation (GO:0045646)3.05910162
67positive regulation of nuclease activity (GO:0032075)3.01993812
68protein export from nucleus (GO:0006611)2.99817480
69negative T cell selection (GO:0043383)2.99140740
70leukocyte aggregation (GO:0070486)2.97377741
71positive regulation of blood vessel endothelial cell migration (GO:0043536)2.97151298
72regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.96792141
73thymic T cell selection (GO:0045061)2.93044540
74negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.92348663
75negative regulation of cell killing (GO:0031342)2.92348663
76modulation by virus of host process (GO:0019054)2.92301822
77formation of translation preinitiation complex (GO:0001731)2.91346927
78definitive hemopoiesis (GO:0060216)2.89803011
79protoporphyrinogen IX metabolic process (GO:0046501)2.89156812
80negative regulation of phagocytosis (GO:0050765)2.83731590
81oxygen transport (GO:0015671)2.82174915
82natural killer cell differentiation (GO:0001779)2.80006625
83cell-substrate junction assembly (GO:0007044)2.79426560
84nuclear pore complex assembly (GO:0051292)2.78301594
85positive regulation of mRNA metabolic process (GO:1903313)2.77525232
86regulation of B cell differentiation (GO:0045577)2.77124819
87modulation by symbiont of host cellular process (GO:0044068)2.76033340
88heterochromatin organization (GO:0070828)2.75443525
89regulation of granulocyte differentiation (GO:0030852)2.73578442
90protein localization to endosome (GO:0036010)2.72402157
91regulation of chromatin binding (GO:0035561)2.71518689
92B cell receptor signaling pathway (GO:0050853)2.70715734
93barbed-end actin filament capping (GO:0051016)2.70603114
94cellular response to epidermal growth factor stimulus (GO:0071364)2.70579017
95glucose catabolic process (GO:0006007)2.69931497
96positive T cell selection (GO:0043368)2.68827094
97endoplasmic reticulum unfolded protein response (GO:0030968)2.68009207
98positive regulation of lamellipodium organization (GO:1902745)2.67624089
99T cell selection (GO:0045058)2.65935982
100ribosomal small subunit biogenesis (GO:0042274)2.65661139
101embryonic process involved in female pregnancy (GO:0060136)2.65610471
102positive regulation of erythrocyte differentiation (GO:0045648)2.65601405
1033-UTR-mediated mRNA stabilization (GO:0070935)2.65351846
104embryonic hemopoiesis (GO:0035162)2.65254410
105peptidyl-lysine dimethylation (GO:0018027)2.65110240
106positive regulation of gene expression, epigenetic (GO:0045815)2.64968283
107positive regulation of mRNA processing (GO:0050685)2.62972523
108regulation of nuclease activity (GO:0032069)2.62689017
109stress fiber assembly (GO:0043149)2.62461835
110activation of MAPKKK activity (GO:0000185)2.62306978
111modulation by virus of host morphology or physiology (GO:0019048)2.62057516
112regulation of interferon-beta biosynthetic process (GO:0045357)2.60828676
113positive regulation of granulocyte differentiation (GO:0030854)2.60627954
114DNA topological change (GO:0006265)2.60098711
115megakaryocyte development (GO:0035855)2.60019725
116positive regulation of protein export from nucleus (GO:0046827)2.58972401
117UV protection (GO:0009650)2.58949695
118histone H4 deacetylation (GO:0070933)2.58758562
119platelet formation (GO:0030220)2.58393978
120response to epidermal growth factor (GO:0070849)2.58355482
121peptidyl-arginine omega-N-methylation (GO:0035247)2.57468451
122glucocorticoid receptor signaling pathway (GO:0042921)2.56738814
123regulation of mRNA 3-end processing (GO:0031440)2.56448597
124ER-nucleus signaling pathway (GO:0006984)2.56423673
125response to prostaglandin E (GO:0034695)2.56035800
126regulation of mitotic spindle organization (GO:0060236)2.55819860
127positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.55081833
128erythrocyte development (GO:0048821)2.53629048
129lamellipodium assembly (GO:0030032)2.53478719
130gene silencing by RNA (GO:0031047)2.52821460
131poly(A)+ mRNA export from nucleus (GO:0016973)2.52609473
132positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.51221889
133response to muramyl dipeptide (GO:0032495)2.50640833
134protein targeting to plasma membrane (GO:0072661)2.48923874
135corticosteroid receptor signaling pathway (GO:0031958)2.47612827
136regulation of response to osmotic stress (GO:0047484)2.46921087
137cellular response to unfolded protein (GO:0034620)2.46036244
138regulation of histone H3-K4 methylation (GO:0051569)2.45821170
139cardiac myofibril assembly (GO:0055003)2.45612021
140cell-cell junction maintenance (GO:0045217)2.43980067
141stress granule assembly (GO:0034063)2.43859131
142negative regulation of histone methylation (GO:0031061)2.43621309
143NADPH regeneration (GO:0006740)2.43293337
144positive regulation of transcription regulatory region DNA binding (GO:2000679)2.42687921
145atrioventricular valve morphogenesis (GO:0003181)2.42511196
146endothelial cell chemotaxis (GO:0035767)2.42386194
147lamellipodium organization (GO:0097581)2.42008961
148embryonic eye morphogenesis (GO:0048048)2.41687416
149vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.41579711
150semaphorin-plexin signaling pathway (GO:0071526)2.41525105
151histone H3-K4 methylation (GO:0051568)2.40856751
152T cell apoptotic process (GO:0070231)2.40199378
153mRNA stabilization (GO:0048255)2.39839060
154RNA stabilization (GO:0043489)2.39839060
155vesicle coating (GO:0006901)2.39826303
156basement membrane organization (GO:0071711)2.39558211
157negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.39083238
158venous blood vessel morphogenesis (GO:0048845)2.38882206
159regulation of cell communication by electrical coupling (GO:0010649)2.38739774
160positive regulation of myotube differentiation (GO:0010831)2.38228666
161ganglioside metabolic process (GO:0001573)2.36283434
162nuclear pore organization (GO:0006999)2.36233580
163negative regulation of striated muscle cell differentiation (GO:0051154)2.35813069
164erythrocyte maturation (GO:0043249)2.35652247
165regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.33635714
166positive regulation of lamellipodium assembly (GO:0010592)2.33386924
167positive regulation by symbiont of host defense response (GO:0052509)2.30530495
168modulation by symbiont of host defense response (GO:0052031)2.30530495
169modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.30530495
170modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.30530495
171positive regulation by organism of defense response of other organism involved in symbiotic interact2.30530495
172modulation by symbiont of host immune response (GO:0052553)2.30530495
173negative regulation of interleukin-12 production (GO:0032695)2.29820525
174positive regulation of natural killer cell differentiation (GO:0032825)2.29113627
175cellular response to zinc ion (GO:0071294)2.28994150
176valine metabolic process (GO:0006573)2.28970588
177mast cell activation (GO:0045576)2.28867145
178pentose-phosphate shunt (GO:0006098)2.27885098
179dosage compensation (GO:0007549)2.27406664
180regulation of NFAT protein import into nucleus (GO:0051532)2.25925264
181positive regulation of RNA splicing (GO:0033120)2.24008619
182mast cell degranulation (GO:0043303)2.23741002
183mast cell activation involved in immune response (GO:0002279)2.23741002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.35264707
2MYC_22102868_ChIP-Seq_BL_Human3.75441726
3SCL_19346495_ChIP-Seq_HPC-7_Human3.73828149
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.38102343
5E2F7_22180533_ChIP-Seq_HELA_Human3.10513485
6VDR_21846776_ChIP-Seq_THP-1_Human2.98708688
7GATA1_22025678_ChIP-Seq_K562_Human2.71796944
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.70254600
9TCF7_22412390_ChIP-Seq_EML_Mouse2.62786288
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59927971
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.46091953
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45505197
13KDM2B_26808549_Chip-Seq_DND41_Human2.42129513
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31219594
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24261234
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23414728
17MAF_26560356_Chip-Seq_TH1_Human2.16388886
18VDR_24763502_ChIP-Seq_THP-1_Human2.13414915
19CIITA_25753668_ChIP-Seq_RAJI_Human2.12814293
20UTX_26944678_Chip-Seq_JUKART_Human2.11164855
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.09985085
22ZNF263_19887448_ChIP-Seq_K562_Human2.07086401
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.04513943
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03834381
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02963398
26GATA1_19941827_ChIP-Seq_MEL_Mouse2.00142194
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94255177
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.90628272
29SPI1_23127762_ChIP-Seq_K562_Human1.90406093
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.88661840
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.88150655
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.86632351
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86073853
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84594376
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83909985
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83636227
37RUNX_20019798_ChIP-Seq_JUKART_Human1.80542209
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78238915
39* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77767184
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76224249
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74583118
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74220570
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71549207
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.69845657
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69800953
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68980285
47CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.68561795
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.67479243
49LXR_22292898_ChIP-Seq_THP-1_Human1.66499559
50* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66352061
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66087324
52MYB_26560356_Chip-Seq_TH2_Human1.65176322
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64323461
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63890596
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63409172
56MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61151086
57MYB_26560356_Chip-Seq_TH1_Human1.59981069
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58335905
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.56004326
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55314294
61* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.54117524
62* P68_20966046_ChIP-Seq_HELA_Human1.53932664
63* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53172239
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.51904122
65FOXM1_23109430_ChIP-Seq_U2OS_Human1.50009577
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49327002
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48347149
68IRF8_27001747_Chip-Seq_BMDM_Mouse1.47496578
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.45668884
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.43774117
71CLOCK_20551151_ChIP-Seq_293T_Human1.43638489
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43628968
73XRN2_22483619_ChIP-Seq_HELA_Human1.43336519
74* NCOR1_26117541_ChIP-Seq_K562_Human1.42845976
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41200257
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.40116997
77CREB1_26743006_Chip-Seq_LNCaP_Human1.38938694
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38395058
79SMC4_20622854_ChIP-Seq_HELA_Human1.36692157
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36656412
81* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36162799
82MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35794948
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33601351
84* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32866017
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31886096
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30979312
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30113428
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29213516
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.29107901
90* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28947434
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28892436
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28088380
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28029666
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26302362
95TBX20_22080862_ChIP-Seq_HEART_Mouse1.24958489
96TBX20_22328084_ChIP-Seq_HEART_Mouse1.24958489
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24841561
98* SPI1_23547873_ChIP-Seq_NB4_Human1.24801744
99ATF3_27146783_Chip-Seq_COLON_Human1.24447625
100* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24231434
101* KDM2B_26808549_Chip-Seq_K562_Human1.23972676
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23394935
103MAF_26560356_Chip-Seq_TH2_Human1.22196731
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22003697
105* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21879348
106STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21120673
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18858520
108SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.17327389
109* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16209381
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14525291
111ESR2_21235772_ChIP-Seq_MCF-7_Human1.13659082
112ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10803053
113TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10162164
114* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10127979
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09672344
116TP53_22127205_ChIP-Seq_IMR90_Human1.09585232
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09231219
118GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08873583
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08793324
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08216261
121GATA2_19941826_ChIP-Seq_K562_Human1.07721184
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07686000
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06596335
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06292926
125IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06279574
126GATA2_21666600_ChIP-Seq_HMVEC_Human1.06118720
127THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06015920
128DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03473250
129ELF1_20517297_ChIP-Seq_JURKAT_Human1.02423171
130STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01722643
131SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01637520
132P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01553063
133RUNX1_27514584_Chip-Seq_MCF-7_Human1.01435060
134GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01430744
135RACK7_27058665_Chip-Seq_MCF-7_Human1.01415324
136MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01385592
137PU_27001747_Chip-Seq_BMDM_Mouse1.00988911
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00152683
139POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00025831
140GATA3_27048872_Chip-Seq_THYMUS_Human0.99904849
141NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99893021
142STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98478758
143SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97631609
144* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96488107
145ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95877769
146TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95305414
147DROSHA_22980978_ChIP-Seq_HELA_Human0.95052077
148GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94834150
149RARA_24833708_ChIP-Seq_LIVER_Mouse0.93718684
150MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93317128
151GATA1_19941826_ChIP-Seq_K562_Human0.93100729
152IRF8_21731497_ChIP-ChIP_J774_Mouse0.92617281
153SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92371021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.37779415
2MP0008438_abnormal_cutaneous_collagen3.07362714
3MP0005451_abnormal_body_composition3.01329241
4MP0004808_abnormal_hematopoietic_stem2.55597034
5MP0000685_abnormal_immune_system2.44629753
6MP0003172_abnormal_lysosome_physiology2.43319510
7MP0003183_abnormal_peptide_metabolism2.41257072
8MP0009278_abnormal_bone_marrow2.40712932
9MP0010307_abnormal_tumor_latency2.33602512
10MP0003300_gastrointestinal_ulcer2.32982218
11MP0002249_abnormal_larynx_morphology2.32444936
12MP0004858_abnormal_nervous_system2.29650420
13MP0005076_abnormal_cell_differentiation2.17398261
14MP0003763_abnormal_thymus_physiology2.17388622
15MP0001835_abnormal_antigen_presentation2.16246677
16MP0004233_abnormal_muscle_weight2.11115838
17MP0001348_abnormal_lacrimal_gland2.06767306
18MP0003705_abnormal_hypodermis_morpholog2.05795620
19MP0003566_abnormal_cell_adhesion2.00261777
20MP0001545_abnormal_hematopoietic_system1.97411581
21MP0005397_hematopoietic_system_phenotyp1.97411581
22MP0002398_abnormal_bone_marrow1.94781612
23MP0004084_abnormal_cardiac_muscle1.94069731
24MP0005464_abnormal_platelet_physiology1.93169642
25MP0005409_darkened_coat_color1.92344710
26MP0000516_abnormal_urinary_system1.92301745
27MP0005367_renal/urinary_system_phenotyp1.92301745
28MP0003436_decreased_susceptibility_to1.88206720
29MP0001800_abnormal_humoral_immune1.80676259
30MP0003303_peritoneal_inflammation1.77963279
31MP0010368_abnormal_lymphatic_system1.75896989
32MP0003111_abnormal_nucleus_morphology1.73251186
33MP0000003_abnormal_adipose_tissue1.72050085
34MP0001790_abnormal_immune_system1.70627682
35MP0005387_immune_system_phenotype1.70627682
36MP0001730_embryonic_growth_arrest1.69198995
37MP0002420_abnormal_adaptive_immunity1.66798647
38MP0000569_abnormal_digit_pigmentation1.63781794
39MP0001819_abnormal_immune_cell1.63408517
40MP0010352_gastrointestinal_tract_polyps1.62997823
41MP0002234_abnormal_pharynx_morphology1.62884987
42MP0000703_abnormal_thymus_morphology1.62066189
43MP0002933_joint_inflammation1.61216339
44MP0004510_myositis1.60586974
45MP0002452_abnormal_antigen_presenting1.59944955
46MP0001873_stomach_inflammation1.59129625
47MP0008260_abnormal_autophagy1.58182527
48MP0006054_spinal_hemorrhage1.57454398
49MP0005375_adipose_tissue_phenotype1.54777823
50MP0004145_abnormal_muscle_electrophysio1.54771881
51MP0000465_gastrointestinal_hemorrhage1.52850188
52MP0000858_altered_metastatic_potential1.52570713
53MP0000751_myopathy1.47828067
54MP0000716_abnormal_immune_system1.47055558
55MP0003123_paternal_imprinting1.46366802
56MP0002723_abnormal_immune_serum1.44222866
57MP0010630_abnormal_cardiac_muscle1.43518179
58MP0002166_altered_tumor_susceptibility1.43453346
59MP0005623_abnormal_meninges_morphology1.41227611
60MP0005671_abnormal_response_to1.41166947
61MP0000689_abnormal_spleen_morphology1.39610493
62MP0002722_abnormal_immune_system1.38375636
63MP0000759_abnormal_skeletal_muscle1.37175370
64MP0002429_abnormal_blood_cell1.37146132
65MP0008961_abnormal_basal_metabolism1.36569686
66MP0005670_abnormal_white_adipose1.36495319
67MP0000350_abnormal_cell_proliferation1.35406072
68MP0005501_abnormal_skin_physiology1.35085637
69MP0000747_muscle_weakness1.34261669
70MP0000681_abnormal_thyroid_gland1.33732398
71MP0002419_abnormal_innate_immunity1.31032380
72MP0002796_impaired_skin_barrier1.30300249
73MP0002060_abnormal_skin_morphology1.29118636
74MP0009840_abnormal_foam_cell1.28962314
75MP0005000_abnormal_immune_tolerance1.28427948
76MP0003453_abnormal_keratinocyte_physiol1.25171753
77MP0004859_abnormal_synaptic_plasticity1.24548016
78MP0003656_abnormal_erythrocyte_physiolo1.24420591
79MP0002080_prenatal_lethality1.22868498
80MP0009672_abnormal_birth_weight1.22542118
81MP0005025_abnormal_response_to1.22459742
82MP0010155_abnormal_intestine_physiology1.18281027
83MP0009333_abnormal_splenocyte_physiolog1.17828165
84MP0004036_abnormal_muscle_relaxation1.17496717
85MP0003329_amyloid_beta_deposits1.16734664
86MP0000537_abnormal_urethra_morphology1.16500789
87MP0010234_abnormal_vibrissa_follicle1.15384526
88MP0004947_skin_inflammation1.15052750
89MP0008007_abnormal_cellular_replicative1.14146607
90MP0003942_abnormal_urinary_system1.13953283
91MP0003866_abnormal_defecation1.12666457
92MP0004147_increased_porphyrin_level1.12643743
93MP0009785_altered_susceptibility_to1.12557319
94MP0004087_abnormal_muscle_fiber1.11670144
95MP0003115_abnormal_respiratory_system1.11105967
96MP0005257_abnormal_intraocular_pressure1.10870097
97MP0005503_abnormal_tendon_morphology1.10302465
98MP0004957_abnormal_blastocyst_morpholog1.10072567
99MP0005621_abnormal_cell_physiology1.07857283
100MP0003984_embryonic_growth_retardation1.05851022
101MP0003385_abnormal_body_wall1.05005081
102MP0000678_abnormal_parathyroid_gland1.04675415
103MP0005380_embryogenesis_phenotype1.03239165
104MP0001672_abnormal_embryogenesis/_devel1.03239165
105MP0010030_abnormal_orbit_morphology1.02169171
106MP0000733_abnormal_muscle_development1.01992283
107MP0009931_abnormal_skin_appearance1.01902489
108MP0002405_respiratory_system_inflammati1.01512346
109MP0002086_abnormal_extraembryonic_tissu1.00664061
110MP0004130_abnormal_muscle_cell0.99803541
111MP0000371_diluted_coat_color0.98219311
112MP0001958_emphysema0.97958180
113MP0003943_abnormal_hepatobiliary_system0.97927516
114MP0003091_abnormal_cell_migration0.97730413
115MP0002088_abnormal_embryonic_growth/wei0.97633647
116MP0005083_abnormal_biliary_tract0.96827126
117MP0003077_abnormal_cell_cycle0.96649169
118MP0004272_abnormal_basement_membrane0.96194844
119MP0000266_abnormal_heart_morphology0.96073076
120MP0009780_abnormal_chondrocyte_physiolo0.95789421
121MP0003693_abnormal_embryo_hatching0.94796632
122MP0005275_abnormal_skin_tensile0.93849721
123MP0001697_abnormal_embryo_size0.93195801
124MP0001533_abnormal_skeleton_physiology0.93168820
125MP0002089_abnormal_postnatal_growth/wei0.92962989
126MP0003279_aneurysm0.91649690
127MP0000534_abnormal_ureter_morphology0.90826185
128MP0008932_abnormal_embryonic_tissue0.90807831
129MP0003045_fibrosis0.90788031
130MP0006138_congestive_heart_failure0.89967886
131MP0003567_abnormal_fetal_cardiomyocyte0.88711418
132MP0003191_abnormal_cellular_cholesterol0.88544240
133MP0002925_abnormal_cardiovascular_devel0.87782961
134MP0002269_muscular_atrophy0.87758096
135MP0000462_abnormal_digestive_system0.87724765
136MP0000490_abnormal_crypts_of0.86646489
137MP0001845_abnormal_inflammatory_respons0.86560762
138MP0009384_cardiac_valve_regurgitation0.86096978
139MP0009115_abnormal_fat_cell0.85890155
140MP0002085_abnormal_embryonic_tissue0.85695767
141MP0000750_abnormal_muscle_regeneration0.85600073
142MP0005023_abnormal_wound_healing0.85402812
143MP0002128_abnormal_blood_circulation0.84608485
144MP0000428_abnormal_craniofacial_morphol0.84539367
145MP0004197_abnormal_fetal_growth/weight/0.83899360
146MP0001544_abnormal_cardiovascular_syste0.83532102
147MP0005385_cardiovascular_system_phenoty0.83532102
148MP0004185_abnormal_adipocyte_glucose0.82830241
149MP0005666_abnormal_adipose_tissue0.82497267
150MP0005330_cardiomyopathy0.82372367
151MP0006292_abnormal_olfactory_placode0.82341435
152MP0001879_abnormal_lymphatic_vessel0.80441069
153MP0002006_tumorigenesis0.80157109
154MP0000767_abnormal_smooth_muscle0.79971141
155MP0002877_abnormal_melanocyte_morpholog0.79597705
156MP0010094_abnormal_chromosome_stability0.79477574
157MP0009379_abnormal_foot_pigmentation0.78623648
158MP0002114_abnormal_axial_skeleton0.76045737
159MP0002970_abnormal_white_adipose0.74492145
160MP0005384_cellular_phenotype0.73923642
161MP0001849_ear_inflammation0.73819785
162MP0002108_abnormal_muscle_morphology0.73011226
163MP0004264_abnormal_extraembryonic_tissu0.70583282
164MP0008770_decreased_survivor_rate0.70127829
165MP0002998_abnormal_bone_remodeling0.70078104
166MP0000313_abnormal_cell_death0.69317250
167MP0005058_abnormal_lysosome_morphology0.69029559

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.13387046
2Abnormal gallbladder physiology (HP:0012438)3.54324450
3Cholecystitis (HP:0001082)3.54324450
4Abnormality of the fingertips (HP:0001211)3.33213172
5Elfin facies (HP:0004428)3.30480813
6Premature rupture of membranes (HP:0001788)3.07372839
7Insomnia (HP:0100785)3.04298779
8Obstructive sleep apnea (HP:0002870)3.03014985
9Truncus arteriosus (HP:0001660)3.02557897
10Reticulocytosis (HP:0001923)3.01817079
11Increased connective tissue (HP:0009025)2.93267633
12Chronic otitis media (HP:0000389)2.90974413
13Hyperthyroidism (HP:0000836)2.84366873
14Long nose (HP:0003189)2.79429999
15Broad metatarsal (HP:0001783)2.75360218
16Achilles tendon contracture (HP:0001771)2.74418878
17Ankyloglossia (HP:0010296)2.70308188
18Cerebral aneurysm (HP:0004944)2.69444106
19Upper limb amyotrophy (HP:0009129)2.66781584
20Distal upper limb amyotrophy (HP:0007149)2.66781584
21Nasal polyposis (HP:0100582)2.66554278
22Broad face (HP:0000283)2.66027889
23Abnormality of the nasal mucosa (HP:0000433)2.65509805
24Renovascular hypertension (HP:0100817)2.65232650
25Distal lower limb amyotrophy (HP:0008944)2.63200608
26Macroorchidism (HP:0000053)2.49839554
27Poor eye contact (HP:0000817)2.48983388
28Ulnar bowing (HP:0003031)2.47223927
29Renal duplication (HP:0000075)2.46378845
30Prolonged bleeding time (HP:0003010)2.45707886
31Fragile skin (HP:0001030)2.45514891
32Recurrent viral infections (HP:0004429)2.44256895
33Bowel incontinence (HP:0002607)2.41836667
34Biconcave vertebral bodies (HP:0004586)2.41513362
35Patellar dislocation (HP:0002999)2.41327782
36Impaired social interactions (HP:0000735)2.39501351
37Abnormal social behavior (HP:0012433)2.39501351
38Atelectasis (HP:0100750)2.37657503
39Abnormality of the Achilles tendon (HP:0005109)2.36214864
40Increased variability in muscle fiber diameter (HP:0003557)2.35554261
41Vertebral compression fractures (HP:0002953)2.34846487
42Fatigue (HP:0012378)2.33935901
43Supranuclear gaze palsy (HP:0000605)2.32834421
44Short 4th metacarpal (HP:0010044)2.32444679
45Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.32444679
46Long palpebral fissure (HP:0000637)2.31941635
47Flat cornea (HP:0007720)2.31906230
48Spinal rigidity (HP:0003306)2.30070635
49Pointed chin (HP:0000307)2.29997377
50Polycythemia (HP:0001901)2.29203926
51Myopathic facies (HP:0002058)2.26934391
52Asymmetry of the thorax (HP:0001555)2.26812751
53Easy fatigability (HP:0003388)2.26204095
54Abnormal large intestine physiology (HP:0012700)2.25125610
55Cellulitis (HP:0100658)2.23371943
56Abnormality of reticulocytes (HP:0004312)2.22186325
57Aortic aneurysm (HP:0004942)2.20957016
58Recurrent bronchitis (HP:0002837)2.20638250
59Overriding aorta (HP:0002623)2.20184245
60Abnormality of oral frenula (HP:0000190)2.17893863
61Abnormality of skeletal muscle fiber size (HP:0012084)2.17498091
62Broad palm (HP:0001169)2.16516430
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.16242354
64IgM deficiency (HP:0002850)2.16237791
65Mitral regurgitation (HP:0001653)2.15027634
66Posterior subcapsular cataract (HP:0007787)2.12922539
67Dysmetric saccades (HP:0000641)2.12438545
68Recurrent fungal infections (HP:0002841)2.12198810
69Hypertensive crisis (HP:0100735)2.11879976
70Thin ribs (HP:0000883)2.11183691
71Gastrointestinal inflammation (HP:0004386)2.10803004
72Tented upper lip vermilion (HP:0010804)2.09330563
73Hand muscle atrophy (HP:0009130)2.08295159
74Abnormality of the tricuspid valve (HP:0001702)2.04684122
75Cervical subluxation (HP:0003308)2.04089904
76Premature skin wrinkling (HP:0100678)2.02933297
77Neurodegeneration (HP:0002180)2.01834172
78Mildly elevated creatine phosphokinase (HP:0008180)2.01532862
79Long toe (HP:0010511)2.00490275
80Thrombocytosis (HP:0001894)2.00347705
81Hypercortisolism (HP:0001578)1.98067454
82Narrow palate (HP:0000189)1.97609985
83Ventricular tachycardia (HP:0004756)1.97315827
84Chest pain (HP:0100749)1.97074388
85Lower limb amyotrophy (HP:0007210)1.95986197
86Abnormality of the thoracic spine (HP:0100711)1.95246755
87Postural instability (HP:0002172)1.94511685
88Bowel diverticulosis (HP:0005222)1.94275036
89Myositis (HP:0100614)1.93474338
90Shallow orbits (HP:0000586)1.91677406
91Inflammation of the large intestine (HP:0002037)1.90457807
92Cholelithiasis (HP:0001081)1.89217283
93Abnormality of the peritoneum (HP:0002585)1.88385909
94Difficulty climbing stairs (HP:0003551)1.87558234
95Abnormality of the calcaneus (HP:0008364)1.87199121
96Increased nuchal translucency (HP:0010880)1.86648157
97Eczematoid dermatitis (HP:0000976)1.85869303
98Stridor (HP:0010307)1.85803229
99Venous abnormality (HP:0002624)1.85526806
100Asymmetric septal hypertrophy (HP:0001670)1.85515727
101Epistaxis (HP:0000421)1.85407562
102Deep palmar crease (HP:0006191)1.84521503
103Hyperparathyroidism (HP:0000843)1.84194863
104Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.83384431
105Deformed sella turcica (HP:0002681)1.83304650
106Emphysema (HP:0002097)1.83174530
107Genu recurvatum (HP:0002816)1.81501225
108Breech presentation (HP:0001623)1.80791345
109Aneurysm (HP:0002617)1.80340995
110Blue sclerae (HP:0000592)1.80255023
111Bicuspid aortic valve (HP:0001647)1.80114516
112J-shaped sella turcica (HP:0002680)1.79393801
113Trigonocephaly (HP:0000243)1.79348847
114Hypoparathyroidism (HP:0000829)1.79225992
115Heterotopia (HP:0002282)1.79151143
116Mediastinal lymphadenopathy (HP:0100721)1.79122983
117Increased density of long bones (HP:0006392)1.79098510
118Enlarged penis (HP:0000040)1.78478003
119Periodontitis (HP:0000704)1.77784760
120Subaortic stenosis (HP:0001682)1.77756277
121Abnormality of the left ventricular outflow tract (HP:0011103)1.77756277
122Trismus (HP:0000211)1.77725750
123Seborrheic dermatitis (HP:0001051)1.77490473
124Distal lower limb muscle weakness (HP:0009053)1.76361581
125Dilatation of the ascending aorta (HP:0005111)1.75468120
126Aortic regurgitation (HP:0001659)1.75425815
127Ureteral stenosis (HP:0000071)1.75375398
128Protrusio acetabuli (HP:0003179)1.75365551
129Abnormality of the endocardium (HP:0004306)1.74766045
130Elevated erythrocyte sedimentation rate (HP:0003565)1.74324044
131Hammertoe (HP:0001765)1.74283228
132Flat acetabular roof (HP:0003180)1.74281668
133Spontaneous hematomas (HP:0007420)1.74112021
134Panhypogammaglobulinemia (HP:0003139)1.73333380
135Persistence of primary teeth (HP:0006335)1.71452562
136Abnormality of the 4th metacarpal (HP:0010012)1.70548445
137Back pain (HP:0003418)1.70417419
138Prominent forehead (HP:0011220)1.69978720
139Abnormal platelet function (HP:0011869)1.69855667
140Impaired platelet aggregation (HP:0003540)1.69855667
141Recurrent abscess formation (HP:0002722)1.69839688
142Syringomyelia (HP:0003396)1.69495933
143Spinal cord lesions (HP:0100561)1.69495933
144Nonimmune hydrops fetalis (HP:0001790)1.69342620
145Peripheral hypomyelination (HP:0007182)1.69107439
146Interstitial pulmonary disease (HP:0006530)1.68970614
147Spondylolisthesis (HP:0003302)1.68513409
148Centrally nucleated skeletal muscle fibers (HP:0003687)1.67840106
149Broad distal phalanx of finger (HP:0009836)1.67417048
150Elbow flexion contracture (HP:0002987)1.67373031
151Disproportionate tall stature (HP:0001519)1.67206459
152Foot dorsiflexor weakness (HP:0009027)1.67034511
153Subcapsular cataract (HP:0000523)1.66949015
154Mitral valve prolapse (HP:0001634)1.66917923
155Hypotelorism (HP:0000601)1.66028258
156Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.65970502
157Bladder diverticulum (HP:0000015)1.65837112
158Advanced eruption of teeth (HP:0006288)1.64820010
159Wormian bones (HP:0002645)1.64818907
160Skin tags (HP:0010609)1.64738955
161Thin bony cortex (HP:0002753)1.63986164
162Exercise-induced myalgia (HP:0003738)1.63850611
163Ankle contracture (HP:0006466)1.63817437
164Long eyelashes (HP:0000527)1.63759141
165Hypercalcemia (HP:0003072)1.63696988
166Atrial fibrillation (HP:0005110)1.63550765
167Absent frontal sinuses (HP:0002688)1.62887608
168Wide nose (HP:0000445)1.62033516
169Acute lymphatic leukemia (HP:0006721)1.61501060
170Reduced subcutaneous adipose tissue (HP:0003758)1.61193888
171Obsessive-compulsive behavior (HP:0000722)1.60793787
172Type 1 muscle fiber predominance (HP:0003803)1.60547010
173Joint laxity (HP:0001388)1.59956215
174Prominent metopic ridge (HP:0005487)1.59764634

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.76832600
2MAP4K13.70982004
3TRIB33.41843396
4SMG13.31649059
5BRD43.17543123
6PRPF4B3.08928583
7ERN12.92825613
8EEF2K2.92340750
9PKN22.88551652
10TTN2.24861953
11SIK22.11809955
12MAP2K31.80538542
13SIK11.80071659
14ZAP701.72647367
15KSR21.69350795
16KIT1.68713995
17NME21.68379302
18JAK31.66631383
19ICK1.65165381
20CAMK1D1.64858626
21BTK1.64049723
22CAMK1G1.53601727
23PRKD31.51644186
24TGFBR11.44146112
25RIPK11.43476207
26TYK21.42238916
27TAOK21.41396671
28PTK61.41037469
29TXK1.40582413
30MAP3K71.40267203
31TBK11.38493371
32EPHB11.37968097
33CSF1R1.26310186
34LATS21.23540758
35CDK121.22950411
36STK241.21765308
37FLT31.20796472
38STK101.19729117
39TAOK31.19443126
40TGFBR21.17366526
41JAK11.14844627
42SCYL21.14634652
43RPS6KB21.12289571
44NTRK11.07468622
45PRKD21.06819921
46LRRK21.06411562
47RIPK41.01600738
48NEK21.00950732
49TESK11.00063234
50NTRK30.99815561
51IRAK40.99526392
52MAPK110.98790925
53SYK0.98150543
54FGFR40.95171633
55MTOR0.92158299
56FGFR30.89921785
57PAK40.89316834
58CDK60.89097665
59IKBKE0.87754738
60HCK0.87071455
61TYRO30.86625328
62SIK30.86087453
63ITK0.84592355
64ILK0.83377050
65FES0.83037204
66EPHA20.82119594
67RPS6KA40.80867944
68ARAF0.80757211
69GRK60.80515192
70MAP3K10.79988416
71PDGFRA0.79641325
72BLK0.78129292
73EIF2AK10.76255113
74PTK20.75699429
75DMPK0.73892856
76KDR0.73813196
77BRAF0.73620580
78PDPK10.73346337
79IRAK20.73341696
80CDK40.72330737
81MAP2K20.70389757
82TESK20.70099898
83TAOK10.68248500
84MARK20.67314801
85MATK0.66447894
86LCK0.66229835
87CAMK40.65904388
88RPS6KA20.65075899
89RAF10.64772466
90MAP3K110.62867189
91JAK20.61240921
92STK40.61162778
93ATR0.60863870
94PAK20.60154679
95SGK30.59849381
96HIPK20.59305565
97CAMKK10.59272971
98PRKCH0.56751475
99MYLK0.56067860
100CLK10.55893020
101RPS6KC10.54907788
102RPS6KL10.54907788
103MST1R0.53672255
104BRSK10.53555841
105CSK0.53540908
106INSRR0.53365242
107ALK0.52703867
108MOS0.52387278
109MAP3K130.52349759
110CDC42BPA0.51639872
111FGFR10.49906669
112MAPK100.49282817
113MAPK120.49229836
114CDK30.48784337
115PRKG20.48258914
116CHUK0.48191235
117CHEK10.47538811
118LYN0.47184731
119CAMK10.46527595
120MAP3K20.45962248
121KSR10.45848495
122BMX0.45794598
123ERBB20.45318972
124LATS10.45145427
125CDK11A0.43869153
126CDK70.43858430
127MAPKAPK30.43799052
128TEC0.43752242
129PDGFRB0.43682199
130CDK20.43590430
131AKT20.42532859
132WNK10.41276908
133PIM20.40709663
134TTK0.40043171
135MAP3K80.39952443
136STK380.39876563
137IRAK30.39715917
138CDK150.39076478
139MAP3K60.39032809
140PDK10.37339512
141SRC0.37175932
142RET0.37037093
143MAP2K60.36953150
144DAPK10.36794796
145MAPKAPK20.36349980
146MAP2K10.36307994
147PTK2B0.36056333
148PAK10.35213808
149CDK10.34903610
150CDK90.34902013
151MAP3K90.34846118
152CDK80.34541066
153PAK60.33630619

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.81248859
2Leishmaniasis_Homo sapiens_hsa051402.08932447
3B cell receptor signaling pathway_Homo sapiens_hsa046622.05839705
4Primary immunodeficiency_Homo sapiens_hsa053402.01522891
5Caffeine metabolism_Homo sapiens_hsa002321.97957004
6Other glycan degradation_Homo sapiens_hsa005111.79228427
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77814060
8Lysine degradation_Homo sapiens_hsa003101.75831237
9Osteoclast differentiation_Homo sapiens_hsa043801.75250429
10Bladder cancer_Homo sapiens_hsa052191.73448136
11Thyroid cancer_Homo sapiens_hsa052161.73322043
12Chronic myeloid leukemia_Homo sapiens_hsa052201.71733871
13Pentose phosphate pathway_Homo sapiens_hsa000301.62864312
14Neurotrophin signaling pathway_Homo sapiens_hsa047221.61614539
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57430503
16Acute myeloid leukemia_Homo sapiens_hsa052211.53542436
17Renal cell carcinoma_Homo sapiens_hsa052111.53354565
18ErbB signaling pathway_Homo sapiens_hsa040121.52003801
19Toxoplasmosis_Homo sapiens_hsa051451.51323047
20Measles_Homo sapiens_hsa051621.50520868
21Prion diseases_Homo sapiens_hsa050201.49258172
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42054118
23Platelet activation_Homo sapiens_hsa046111.41208181
24Biosynthesis of amino acids_Homo sapiens_hsa012301.36784052
25T cell receptor signaling pathway_Homo sapiens_hsa046601.34012423
26Non-small cell lung cancer_Homo sapiens_hsa052231.33674097
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32723975
28Fructose and mannose metabolism_Homo sapiens_hsa000511.29825381
29DNA replication_Homo sapiens_hsa030301.28228823
30Insulin resistance_Homo sapiens_hsa049311.24954069
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22859798
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22134109
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21464753
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.20132307
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19153856
36Shigellosis_Homo sapiens_hsa051311.18630168
37Viral myocarditis_Homo sapiens_hsa054161.17667948
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.17458160
39Hematopoietic cell lineage_Homo sapiens_hsa046401.16141444
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15430886
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14531200
42Small cell lung cancer_Homo sapiens_hsa052221.13159037
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12578629
44AMPK signaling pathway_Homo sapiens_hsa041521.11734127
45Long-term potentiation_Homo sapiens_hsa047201.11550472
46Pancreatic cancer_Homo sapiens_hsa052121.09991132
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09053423
48Herpes simplex infection_Homo sapiens_hsa051681.08935004
49VEGF signaling pathway_Homo sapiens_hsa043701.08678345
50Antigen processing and presentation_Homo sapiens_hsa046121.08228532
51Type II diabetes mellitus_Homo sapiens_hsa049301.07683235
52NF-kappa B signaling pathway_Homo sapiens_hsa040641.07328051
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05327111
54TNF signaling pathway_Homo sapiens_hsa046681.05240943
55mRNA surveillance pathway_Homo sapiens_hsa030151.05229426
56Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04819540
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.04337765
58Proteoglycans in cancer_Homo sapiens_hsa052051.03618116
59Dilated cardiomyopathy_Homo sapiens_hsa054141.03268763
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02385998
61Influenza A_Homo sapiens_hsa051641.01884651
62Phospholipase D signaling pathway_Homo sapiens_hsa040721.01083390
63Central carbon metabolism in cancer_Homo sapiens_hsa052301.01023339
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99948686
65Prostate cancer_Homo sapiens_hsa052150.99934932
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99604182
67Choline metabolism in cancer_Homo sapiens_hsa052310.99292364
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98920523
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.97862723
70Glioma_Homo sapiens_hsa052140.97857540
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97044184
72Endometrial cancer_Homo sapiens_hsa052130.96935117
73Notch signaling pathway_Homo sapiens_hsa043300.96909678
74HTLV-I infection_Homo sapiens_hsa051660.96837146
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95627116
76Prolactin signaling pathway_Homo sapiens_hsa049170.95360505
77Tuberculosis_Homo sapiens_hsa051520.95134217
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.92363706
79Galactose metabolism_Homo sapiens_hsa000520.90817350
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89640581
81Hepatitis B_Homo sapiens_hsa051610.89452792
82Colorectal cancer_Homo sapiens_hsa052100.89106455
83mTOR signaling pathway_Homo sapiens_hsa041500.88309765
84Pertussis_Homo sapiens_hsa051330.87926388
85Spliceosome_Homo sapiens_hsa030400.86214312
86Cell cycle_Homo sapiens_hsa041100.86067037
87Chemokine signaling pathway_Homo sapiens_hsa040620.85401763
88Focal adhesion_Homo sapiens_hsa045100.84561101
89Carbon metabolism_Homo sapiens_hsa012000.84482484
90HIF-1 signaling pathway_Homo sapiens_hsa040660.80584231
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80391184
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80280129
93Sulfur relay system_Homo sapiens_hsa041220.78931370
94FoxO signaling pathway_Homo sapiens_hsa040680.78550617
95Mismatch repair_Homo sapiens_hsa034300.76282707
96N-Glycan biosynthesis_Homo sapiens_hsa005100.75677159
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75524112
98Apoptosis_Homo sapiens_hsa042100.74671387
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.73767721
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73480418
101Salmonella infection_Homo sapiens_hsa051320.72412308
102Endocytosis_Homo sapiens_hsa041440.71855701
103Melanogenesis_Homo sapiens_hsa049160.71413722
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71396742
105Base excision repair_Homo sapiens_hsa034100.71005863
106Glucagon signaling pathway_Homo sapiens_hsa049220.70227813
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70144335
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68214197
109Insulin signaling pathway_Homo sapiens_hsa049100.67969591
110ABC transporters_Homo sapiens_hsa020100.66423341
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65787952
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.65772009
113Rap1 signaling pathway_Homo sapiens_hsa040150.65544961
114Amoebiasis_Homo sapiens_hsa051460.64488548
115Viral carcinogenesis_Homo sapiens_hsa052030.63294491
116Gap junction_Homo sapiens_hsa045400.63007085
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62126567
118Adherens junction_Homo sapiens_hsa045200.62041354
119Inositol phosphate metabolism_Homo sapiens_hsa005620.61455095
120MAPK signaling pathway_Homo sapiens_hsa040100.61351874
121Vibrio cholerae infection_Homo sapiens_hsa051100.60713568
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60373866
123Gastric acid secretion_Homo sapiens_hsa049710.59725149
124Glycerolipid metabolism_Homo sapiens_hsa005610.59221165
125MicroRNAs in cancer_Homo sapiens_hsa052060.58606419
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58283681
127Hepatitis C_Homo sapiens_hsa051600.57472175
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56988603
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56980357
130Legionellosis_Homo sapiens_hsa051340.56504636
131Melanoma_Homo sapiens_hsa052180.54432730
132GnRH signaling pathway_Homo sapiens_hsa049120.54370911
133Fatty acid metabolism_Homo sapiens_hsa012120.54291758
134ECM-receptor interaction_Homo sapiens_hsa045120.52826349
135Pathways in cancer_Homo sapiens_hsa052000.51652882
136Synaptic vesicle cycle_Homo sapiens_hsa047210.51646958
137Epstein-Barr virus infection_Homo sapiens_hsa051690.50465928
138RNA transport_Homo sapiens_hsa030130.49250711
1392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48900253
140Estrogen signaling pathway_Homo sapiens_hsa049150.47873303

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