CKAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.29292364
2DNA ligation (GO:0006266)5.22168674
3mitotic metaphase plate congression (GO:0007080)5.18816954
4kinetochore organization (GO:0051383)4.97100032
5protein localization to chromosome, centromeric region (GO:0071459)4.69606364
6metaphase plate congression (GO:0051310)4.62818976
7mitotic sister chromatid segregation (GO:0000070)4.58904326
8CENP-A containing nucleosome assembly (GO:0034080)4.56310874
9chromatin remodeling at centromere (GO:0031055)4.54727010
10nuclear pore organization (GO:0006999)4.54413002
11nuclear pore complex assembly (GO:0051292)4.49588173
12kinetochore assembly (GO:0051382)4.40363960
13regulation of spindle organization (GO:0090224)4.36303820
14DNA unwinding involved in DNA replication (GO:0006268)4.35710921
15sister chromatid segregation (GO:0000819)4.32614106
16DNA replication initiation (GO:0006270)4.29427131
17attachment of spindle microtubules to kinetochore (GO:0008608)4.28933005
18DNA strand elongation involved in DNA replication (GO:0006271)4.28791954
19mitotic chromosome condensation (GO:0007076)4.23470156
20establishment of chromosome localization (GO:0051303)4.20358171
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.18809850
22regulation of mitotic spindle organization (GO:0060236)4.11803876
23mitotic nuclear envelope disassembly (GO:0007077)4.10099143
24DNA strand elongation (GO:0022616)4.09292130
25DNA replication-independent nucleosome assembly (GO:0006336)4.08449456
26DNA replication-independent nucleosome organization (GO:0034724)4.08449456
27DNA replication checkpoint (GO:0000076)4.00252573
28telomere maintenance via semi-conservative replication (GO:0032201)3.99219113
29establishment of integrated proviral latency (GO:0075713)3.91446146
30histone exchange (GO:0043486)3.87566667
31DNA replication-dependent nucleosome assembly (GO:0006335)3.85602233
32DNA replication-dependent nucleosome organization (GO:0034723)3.85602233
33spindle checkpoint (GO:0031577)3.83172408
34membrane disassembly (GO:0030397)3.81654182
35nuclear envelope disassembly (GO:0051081)3.81654182
36ventricular cardiac muscle cell development (GO:0055015)3.80333636
37mitotic recombination (GO:0006312)3.77489437
38negative regulation of mitosis (GO:0045839)3.75011251
39telomere maintenance via recombination (GO:0000722)3.73787216
40meiotic chromosome segregation (GO:0045132)3.72918002
41positive regulation of chromosome segregation (GO:0051984)3.72703116
42DNA packaging (GO:0006323)3.70727315
43regulation of chromosome segregation (GO:0051983)3.66211658
44mitotic G2/M transition checkpoint (GO:0044818)3.65628142
45spindle assembly checkpoint (GO:0071173)3.64261231
46negative regulation of chromosome segregation (GO:0051985)3.63868782
47regulation of mitotic metaphase/anaphase transition (GO:0030071)3.63767119
48regulation of DNA endoreduplication (GO:0032875)3.63398279
49negative regulation of mitotic sister chromatid separation (GO:2000816)3.62559734
50negative regulation of mitotic sister chromatid segregation (GO:0033048)3.62559734
51negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.62559734
52negative regulation of sister chromatid segregation (GO:0033046)3.62559734
53protein localization to chromosome (GO:0034502)3.58232584
54regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.58211225
55maturation of SSU-rRNA (GO:0030490)3.57323892
56mitotic spindle checkpoint (GO:0071174)3.56990684
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.55405265
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.55284510
59mitotic spindle assembly checkpoint (GO:0007094)3.55004897
60regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.53660319
61positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.53604435
62positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.53604435
63positive regulation of mitotic sister chromatid separation (GO:1901970)3.53604435
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.49174381
65microtubule depolymerization (GO:0007019)3.49154525
66chromosome segregation (GO:0007059)3.47730159
67telomere maintenance via telomere lengthening (GO:0010833)3.46907525
68regulation of sister chromatid segregation (GO:0033045)3.46050202
69regulation of mitotic sister chromatid separation (GO:0010965)3.46050202
70regulation of mitotic sister chromatid segregation (GO:0033047)3.46050202
71protein K6-linked ubiquitination (GO:0085020)3.45042379
72pore complex assembly (GO:0046931)3.44310557
73regulation of centrosome cycle (GO:0046605)3.37053367
74mitotic spindle organization (GO:0007052)3.37028158
75mitotic sister chromatid cohesion (GO:0007064)3.35035583
76nucleobase biosynthetic process (GO:0046112)3.34908411
77chromatin assembly or disassembly (GO:0006333)3.32988748
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.32533755
79regulation of nuclear cell cycle DNA replication (GO:0033262)3.31387928
80negative regulation of nuclear division (GO:0051784)3.27219860
81negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.26892566
82negative regulation of cell division (GO:0051782)3.26660685
83regulation of centriole replication (GO:0046599)3.26179874
84ribosomal small subunit assembly (GO:0000028)3.25515674
85nucleotide-excision repair, DNA gap filling (GO:0006297)3.24508165
86mitotic G2 DNA damage checkpoint (GO:0007095)3.23951338
87double-strand break repair via nonhomologous end joining (GO:0006303)3.22473434
88non-recombinational repair (GO:0000726)3.22473434
89resolution of meiotic recombination intermediates (GO:0000712)3.21964858
90DNA duplex unwinding (GO:0032508)3.21553831
91DNA geometric change (GO:0032392)3.21513975
92regulation of telomere maintenance via telomerase (GO:0032210)3.21017265
93folic acid-containing compound biosynthetic process (GO:0009396)3.20561925
94spindle assembly involved in mitosis (GO:0090307)3.20270344
95replication fork processing (GO:0031297)3.18016457
96DNA topological change (GO:0006265)3.17888414
97regulation of sister chromatid cohesion (GO:0007063)3.17335798
98IMP biosynthetic process (GO:0006188)3.16265290
99ATP-dependent chromatin remodeling (GO:0043044)3.14908750
100formation of translation preinitiation complex (GO:0001731)3.14641459
101mitotic nuclear division (GO:0007067)3.10833223
102histone-serine phosphorylation (GO:0035404)3.10830172
103regulation of helicase activity (GO:0051095)3.10280662
104ribosome assembly (GO:0042255)3.09444547
105mitotic cell cycle checkpoint (GO:0007093)3.08736951
106negative regulation of proteasomal protein catabolic process (GO:1901799)3.07605132
107negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07361371
108DNA double-strand break processing (GO:0000729)3.05501860
109regulation of double-strand break repair via homologous recombination (GO:0010569)3.05414169
110somatic hypermutation of immunoglobulin genes (GO:0016446)3.04780040
111somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04780040
112purine nucleobase biosynthetic process (GO:0009113)3.04714322
113ribosomal large subunit biogenesis (GO:0042273)3.03720647
114negative regulation of DNA-dependent DNA replication (GO:2000104)3.03010226
115chromosome organization (GO:0051276)3.02439495
116regulation of centrosome duplication (GO:0010824)2.99665825
117microtubule polymerization or depolymerization (GO:0031109)2.98357464
118regulation of histone H3-K9 methylation (GO:0051570)2.98237475
119centriole replication (GO:0007099)2.97870820
120chromosome condensation (GO:0030261)2.95667818
121ribosome biogenesis (GO:0042254)2.95208090
122mismatch repair (GO:0006298)2.94540944
123translational termination (GO:0006415)2.93863446
124mitotic cell cycle (GO:0000278)2.93798206
125DNA conformation change (GO:0071103)2.93000857
126viral transcription (GO:0019083)2.92900982
127nuclear envelope organization (GO:0006998)2.92861771
128ribonucleoprotein complex biogenesis (GO:0022613)2.90250755
129telomere maintenance (GO:0000723)2.86135503

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.80975575
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.20824126
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.52876059
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.10449091
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.06264950
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03117979
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87195526
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.85429372
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73404731
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71654079
11AR_21909140_ChIP-Seq_LNCAP_Human2.64962714
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47577124
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46308029
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.41307777
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34830075
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.31843069
17MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.31399162
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.29919791
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26324648
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22423852
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.16971958
22XRN2_22483619_ChIP-Seq_HELA_Human2.15823654
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.15300759
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07898784
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05563110
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95873127
27* VDR_23849224_ChIP-Seq_CD4+_Human1.86149652
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84071493
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.82428890
30FOXP3_21729870_ChIP-Seq_TREG_Human1.74924195
31DCP1A_22483619_ChIP-Seq_HELA_Human1.74721340
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73038323
33TTF2_22483619_ChIP-Seq_HELA_Human1.72766538
34ELK1_19687146_ChIP-ChIP_HELA_Human1.71976651
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70514482
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66580342
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65060008
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60515157
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.57629737
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.57109741
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56279597
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.55669419
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49970700
44GABP_19822575_ChIP-Seq_HepG2_Human1.49512718
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45592515
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42496582
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42296212
48EWS_26573619_Chip-Seq_HEK293_Human1.42293229
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41712875
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39791094
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39624142
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36966674
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34803000
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34656527
55* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31692920
56CIITA_25753668_ChIP-Seq_RAJI_Human1.31671068
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29290799
58KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.27730626
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.27730626
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.27730626
61KDM5A_27292631_Chip-Seq_BREAST_Human1.26962531
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26274337
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26045322
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25357427
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22589958
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19882144
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19175710
68FUS_26573619_Chip-Seq_HEK293_Human1.17731603
69MYC_22102868_ChIP-Seq_BL_Human1.17606009
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17452461
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17151414
72* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15486084
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14515102
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14397103
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12947663
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.12016975
77TFEB_21752829_ChIP-Seq_HELA_Human1.09283738
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.08490086
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08399001
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06587563
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06279934
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03129265
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01997840
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01921000
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00474392
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99718052
87NANOG_21062744_ChIP-ChIP_HESCs_Human0.98847231
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98587037
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98206136
90* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96915139
91ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96066303
92TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95943353
93MYC_18940864_ChIP-ChIP_HL60_Human0.95117487
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92503359
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91332276
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90490785
97NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88635400
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.87195959
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86300971
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82765843
101NANOG_16153702_ChIP-ChIP_HESCs_Human0.82542740
102NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82185956
103SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79647462
104POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78388852
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.77026559
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.76335104
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76312093
108* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71842390
109FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.70150867
110* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68177310
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.65735642
112WT1_19549856_ChIP-ChIP_CCG9911_Human0.65563929
113SOX9_26525672_Chip-Seq_HEART_Mouse0.63032834
114CHD1_26751641_Chip-Seq_LNCaP_Human0.62226336
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.61975839
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.60486741
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.59010415
118IRF1_19129219_ChIP-ChIP_H3396_Human0.58034174
119ZNF274_21170338_ChIP-Seq_K562_Hela0.57854283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.79045638
2MP0010094_abnormal_chromosome_stability4.64397750
3MP0003111_abnormal_nucleus_morphology4.53065280
4MP0004957_abnormal_blastocyst_morpholog3.92820591
5MP0003077_abnormal_cell_cycle3.92574613
6MP0008057_abnormal_DNA_replication3.42209233
7MP0008007_abnormal_cellular_replicative3.00232664
8MP0008058_abnormal_DNA_repair2.98420163
9MP0008932_abnormal_embryonic_tissue2.61388201
10MP0010352_gastrointestinal_tract_polyps2.43311449
11MP0000350_abnormal_cell_proliferation2.23256942
12MP0010307_abnormal_tumor_latency2.16601417
13MP0001730_embryonic_growth_arrest2.12422327
14MP0003786_premature_aging2.00887926
15MP0003941_abnormal_skin_development1.98226416
16MP0010030_abnormal_orbit_morphology1.95246219
17MP0003123_paternal_imprinting1.85374619
18MP0008877_abnormal_DNA_methylation1.82565738
19MP0001672_abnormal_embryogenesis/_devel1.75794150
20MP0005380_embryogenesis_phenotype1.75794150
21MP0001697_abnormal_embryo_size1.73622459
22MP0002085_abnormal_embryonic_tissue1.68414270
23MP0003718_maternal_effect1.66686499
24MP0002396_abnormal_hematopoietic_system1.57137646
25MP0002084_abnormal_developmental_patter1.56590530
26MP0003984_embryonic_growth_retardation1.52658134
27MP0004197_abnormal_fetal_growth/weight/1.50090452
28MP0002088_abnormal_embryonic_growth/wei1.49507715
29MP0002080_prenatal_lethality1.47133089
30MP0002086_abnormal_extraembryonic_tissu1.45505401
31MP0005076_abnormal_cell_differentiation1.44008423
32MP0000490_abnormal_crypts_of1.42513530
33MP0004808_abnormal_hematopoietic_stem1.41792996
34MP0006292_abnormal_olfactory_placode1.36971107
35MP0003890_abnormal_embryonic-extraembry1.36539546
36MP0001293_anophthalmia1.36304061
37MP0003121_genomic_imprinting1.34918818
38MP0003136_yellow_coat_color1.33519443
39MP0000313_abnormal_cell_death1.30139769
40MP0002210_abnormal_sex_determination1.29550584
41MP0009053_abnormal_anal_canal1.28621157
42MP0008789_abnormal_olfactory_epithelium1.27722588
43MP0002234_abnormal_pharynx_morphology1.27355599
44MP0003937_abnormal_limbs/digits/tail_de1.23106344
45MP0001346_abnormal_lacrimal_gland1.21615706
46MP0000372_irregular_coat_pigmentation1.21407847
47MP0002019_abnormal_tumor_incidence1.20799844
48MP0002009_preneoplasia1.16018938
49MP0003567_abnormal_fetal_cardiomyocyte1.15255878
50MP0002233_abnormal_nose_morphology1.15114360
51MP0001529_abnormal_vocalization1.14048412
52MP0008438_abnormal_cutaneous_collagen1.12017502
53MP0002111_abnormal_tail_morphology1.11707688
54MP0001145_abnormal_male_reproductive1.11540002
55MP0003705_abnormal_hypodermis_morpholog1.11000631
56MP0000537_abnormal_urethra_morphology1.07578499
57MP0009379_abnormal_foot_pigmentation1.07088669
58MP0002653_abnormal_ependyma_morphology1.04075889
59MP0001929_abnormal_gametogenesis0.99881603
60MP0005171_absent_coat_pigmentation0.98799253
61MP0003119_abnormal_digestive_system0.98491563
62MP0000653_abnormal_sex_gland0.98444954
63MP0004133_heterotaxia0.95987287
64MP0000428_abnormal_craniofacial_morphol0.94247591
65MP0001286_abnormal_eye_development0.93005312
66MP0003566_abnormal_cell_adhesion0.92534910
67MP0005023_abnormal_wound_healing0.91129363
68MP0003385_abnormal_body_wall0.90416065
69MP0005503_abnormal_tendon_morphology0.89372942
70MP0003315_abnormal_perineum_morphology0.88563798
71MP0001119_abnormal_female_reproductive0.87148366
72MP0005394_taste/olfaction_phenotype0.87116942
73MP0005499_abnormal_olfactory_system0.87116942
74MP0000432_abnormal_head_morphology0.87062566
75MP0006035_abnormal_mitochondrial_morpho0.86681287
76MP0006054_spinal_hemorrhage0.86653888
77MP0006072_abnormal_retinal_apoptosis0.86437336
78MP0002102_abnormal_ear_morphology0.86321989
79MP0002877_abnormal_melanocyte_morpholog0.84353518
80MP0000733_abnormal_muscle_development0.83810136
81MP0003755_abnormal_palate_morphology0.82300038
82MP0001915_intracranial_hemorrhage0.82070946
83MP0005391_vision/eye_phenotype0.80236270
84MP0002092_abnormal_eye_morphology0.79722569
85MP0002132_abnormal_respiratory_system0.79432177
86MP0002697_abnormal_eye_size0.79408962
87MP0009250_abnormal_appendicular_skeleto0.78977880
88MP0005623_abnormal_meninges_morphology0.77599442
89MP0000647_abnormal_sebaceous_gland0.77582903
90MP0000566_synostosis0.76907290
91MP0005408_hypopigmentation0.76730956
92MP0002938_white_spotting0.75683870
93MP0000858_altered_metastatic_potential0.75669252
94MP0005187_abnormal_penis_morphology0.75614752
95MP0001545_abnormal_hematopoietic_system0.75157242
96MP0005397_hematopoietic_system_phenotyp0.75157242
97MP0005384_cellular_phenotype0.74857113
98MP0009703_decreased_birth_body0.74597247
99MP0002160_abnormal_reproductive_system0.74362047
100MP0009672_abnormal_birth_weight0.73994267
101MP0005621_abnormal_cell_physiology0.73827567
102MP0002932_abnormal_joint_morphology0.72850740
103MP0003806_abnormal_nucleotide_metabolis0.72451131
104MP0000703_abnormal_thymus_morphology0.72305823
105MP0003935_abnormal_craniofacial_develop0.71935527
106MP0003698_abnormal_male_reproductive0.70740107
107MP0009697_abnormal_copulation0.70180470
108MP0002075_abnormal_coat/hair_pigmentati0.68815321
109MP0001727_abnormal_embryo_implantation0.68725764
110MP0000358_abnormal_cell_content/0.68562479
111MP0002751_abnormal_autonomic_nervous0.67750371
112MP0002095_abnormal_skin_pigmentation0.67704420
113MP0005248_abnormal_Harderian_gland0.67523751
114MP0000516_abnormal_urinary_system0.66720436
115MP0005367_renal/urinary_system_phenotyp0.66720436
116MP0005395_other_phenotype0.66116983
117MP0000049_abnormal_middle_ear0.65658116
118MP0001186_pigmentation_phenotype0.64913929
119MP0003943_abnormal_hepatobiliary_system0.64823780
120MP0002114_abnormal_axial_skeleton0.64534096
121MP0000631_abnormal_neuroendocrine_gland0.64211472
122MP0005501_abnormal_skin_physiology0.63907610
123MP0002177_abnormal_outer_ear0.63673284
124MP0003115_abnormal_respiratory_system0.63390853
125MP0001299_abnormal_eye_distance/0.63294471
126MP0003861_abnormal_nervous_system0.63214395
127MP0002161_abnormal_fertility/fecundity0.62246528
128MP0005389_reproductive_system_phenotype0.61727325
129MP0002925_abnormal_cardiovascular_devel0.59418761

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.56865199
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.43980000
3Birth length less than 3rd percentile (HP:0003561)4.06887987
4Reticulocytopenia (HP:0001896)3.83897253
5Cortical dysplasia (HP:0002539)3.65663958
6Breast hypoplasia (HP:0003187)3.58034991
7Abnormality of chromosome stability (HP:0003220)3.46179440
8Colon cancer (HP:0003003)3.40731574
9Meckel diverticulum (HP:0002245)3.37853732
10Patellar aplasia (HP:0006443)3.20714631
11Medulloblastoma (HP:0002885)3.19746098
12Abnormality of the ileum (HP:0001549)3.18189388
13Aplasia/Hypoplasia of the uvula (HP:0010293)3.15949334
14Abnormality of the preputium (HP:0100587)3.15113133
15Selective tooth agenesis (HP:0001592)3.06661867
16Ependymoma (HP:0002888)3.04865107
17Increased nuchal translucency (HP:0010880)3.04109097
18Aplasia/Hypoplasia of the patella (HP:0006498)2.96649250
19Absent radius (HP:0003974)2.93341986
20Duodenal stenosis (HP:0100867)2.89459383
21Small intestinal stenosis (HP:0012848)2.89459383
22Abnormality of the labia minora (HP:0012880)2.80499322
23Abnormality of the carotid arteries (HP:0005344)2.76436540
24Absent forearm bone (HP:0003953)2.74014996
25Aplasia involving forearm bones (HP:0009822)2.74014996
26Absent thumb (HP:0009777)2.73298847
27Impulsivity (HP:0100710)2.65268780
28Myelodysplasia (HP:0002863)2.60488017
29Ectopic kidney (HP:0000086)2.58572532
30Rhabdomyosarcoma (HP:0002859)2.55146116
31Carpal bone hypoplasia (HP:0001498)2.52110788
32Oral leukoplakia (HP:0002745)2.46440663
33Sloping forehead (HP:0000340)2.43481702
34Volvulus (HP:0002580)2.43112271
35Abnormal number of incisors (HP:0011064)2.42044593
36Supernumerary spleens (HP:0009799)2.40925781
37Abnormality of the duodenum (HP:0002246)2.40277231
38Embryonal neoplasm (HP:0002898)2.38379540
39Duplicated collecting system (HP:0000081)2.37407997
40Neoplasm of the pancreas (HP:0002894)2.36805531
4111 pairs of ribs (HP:0000878)2.36670912
42Deviation of the thumb (HP:0009603)2.35299796
43Proximal placement of thumb (HP:0009623)2.35203164
44Hypoplastic pelvis (HP:0008839)2.33785908
45Abnormal lung lobation (HP:0002101)2.32586433
46Abnormality of the anterior horn cell (HP:0006802)2.32046995
47Degeneration of anterior horn cells (HP:0002398)2.32046995
48Glioma (HP:0009733)2.31288507
49Abnormality of abdominal situs (HP:0011620)2.29782122
50Abdominal situs inversus (HP:0003363)2.29782122
51Triphalangeal thumb (HP:0001199)2.27291020
52Missing ribs (HP:0000921)2.26801999
53Agnosia (HP:0010524)2.25764452
54Astrocytoma (HP:0009592)2.25691202
55Abnormality of the astrocytes (HP:0100707)2.25691202
56Tracheoesophageal fistula (HP:0002575)2.24444503
57Atresia of the external auditory canal (HP:0000413)2.23979098
58Abnormality of chromosome segregation (HP:0002916)2.22400753
59Nephroblastoma (Wilms tumor) (HP:0002667)2.21185404
60Short thumb (HP:0009778)2.20371424
61Long clavicles (HP:0000890)2.15611980
62Abnormality of the fetal cardiovascular system (HP:0010948)2.15510195
63Abnormal umbilical cord blood vessels (HP:0011403)2.15510195
64Single umbilical artery (HP:0001195)2.15510195
65Abnormality of the renal collecting system (HP:0004742)2.14131157
66Horseshoe kidney (HP:0000085)2.11940493
67Abnormality of cells of the erythroid lineage (HP:0012130)2.10855543
68Bone marrow hypocellularity (HP:0005528)2.09925845
69Embryonal renal neoplasm (HP:0011794)2.09658519
70Aplasia/Hypoplasia of the sternum (HP:0006714)2.09493534
71Rough bone trabeculation (HP:0100670)2.08742710
72Facial hemangioma (HP:0000329)2.08547226
73Neoplasm of the colon (HP:0100273)2.06816758
74Aplastic anemia (HP:0001915)2.04663873
75Short 4th metacarpal (HP:0010044)2.04646267
76Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.04646267
77Neoplasm of the oral cavity (HP:0100649)2.01569317
78Cafe-au-lait spot (HP:0000957)1.99919189
79Renal duplication (HP:0000075)1.98315971
80Basal cell carcinoma (HP:0002671)1.98033777
81Aplasia/hypoplasia of the humerus (HP:0006507)1.97716220
82Abnormality of the septum pellucidum (HP:0007375)1.97469302
83Deep philtrum (HP:0002002)1.93728458
84Neoplasm of striated muscle (HP:0009728)1.93581314
85Squamous cell carcinoma (HP:0002860)1.93437811
86Biliary tract neoplasm (HP:0100574)1.93070904
87Premature graying of hair (HP:0002216)1.92574539
88Trismus (HP:0000211)1.92320214
89Abnormal number of erythroid precursors (HP:0012131)1.91863584
90Clubbing of toes (HP:0100760)1.90660948
91High anterior hairline (HP:0009890)1.88806989
92Absent septum pellucidum (HP:0001331)1.86990478
93Pallor (HP:0000980)1.86464020
94Ovarian neoplasm (HP:0100615)1.83954104
95Spinal muscular atrophy (HP:0007269)1.83141952
96Ankle contracture (HP:0006466)1.82736330
97Septo-optic dysplasia (HP:0100842)1.82502863
98Oligodactyly (hands) (HP:0001180)1.80782537
99Overlapping toe (HP:0001845)1.80144748
100Macrocytic anemia (HP:0001972)1.79965744
101Duplication of thumb phalanx (HP:0009942)1.79221476
102Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79135134
103Abnormality of DNA repair (HP:0003254)1.77293507
104Abnormality of the umbilical cord (HP:0010881)1.77236185
105Abnormal auditory evoked potentials (HP:0006958)1.77222254
106Microvesicular hepatic steatosis (HP:0001414)1.77197379
107Oligodactyly (HP:0012165)1.75629267
108Bowel diverticulosis (HP:0005222)1.75623966
109Slender long bone (HP:0003100)1.73553559
110Choanal atresia (HP:0000453)1.73376097
111Abnormality of the proximal phalanges of the hand (HP:0009834)1.72602506
112Malignant gastrointestinal tract tumors (HP:0006749)1.71619323
113Gastrointestinal carcinoma (HP:0002672)1.71619323
114Abnormality of glycolysis (HP:0004366)1.71288361
115Rib fusion (HP:0000902)1.68470801
116Short humerus (HP:0005792)1.68062670
117High pitched voice (HP:0001620)1.67629431
118Dandy-Walker malformation (HP:0001305)1.66924142
119Abnormality of cochlea (HP:0000375)1.66526732
120Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66228557
121Amaurosis fugax (HP:0100576)1.65558904
122Arteriovenous malformation (HP:0100026)1.64387203
123Increased serum pyruvate (HP:0003542)1.64287416
124Abnormality of the phalanges of the hallux (HP:0010057)1.64142156
125Cleft eyelid (HP:0000625)1.64133769
126Esophageal atresia (HP:0002032)1.63783988
127Facial cleft (HP:0002006)1.62277152
128Holoprosencephaly (HP:0001360)1.60980906
129Preaxial hand polydactyly (HP:0001177)1.60472874
130Intestinal atresia (HP:0011100)1.60119573
131Anal atresia (HP:0002023)1.59819520
132Small hand (HP:0200055)1.59289852
133Gastrointestinal atresia (HP:0002589)1.56653924
134Intestinal polyposis (HP:0200008)1.53689096
135Multiple enchondromatosis (HP:0005701)1.53033296
136Pancreatic islet-cell hyperplasia (HP:0004510)1.52569617
137Hypoplasia of the capital femoral epiphysis (HP:0003090)1.51927586
138Bifid tongue (HP:0010297)1.51355203
139Broad distal phalanx of finger (HP:0009836)1.50753810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.82922803
2CDC74.45832622
3WEE14.10130872
4NEK23.18507585
5TTK3.14723402
6SRPK12.73244123
7PLK12.40768987
8PLK42.32966137
9EIF2AK12.30901590
10NEK12.27158325
11BRSK22.27121702
12CDK122.13721077
13ACVR1B2.05778528
14ZAK2.02390812
15VRK21.97465309
16TLK11.96793304
17* AURKB1.96780636
18MKNK11.88909505
19CHEK21.88521021
20PLK31.86513974
21ATR1.81790500
22EPHA21.80181814
23CDK71.77853794
24RPS6KB21.74173713
25VRK11.52182082
26PASK1.50546670
27TAF11.48827918
28MAP3K81.48017361
29TRIM281.46958670
30MKNK21.46936600
31CHEK11.39338091
32AURKA1.38828737
33STK101.38658267
34STK41.38544368
35DYRK31.38237470
36RPS6KA41.36243637
37TESK21.35642461
38BRSK11.33173262
39CDK41.30727369
40TSSK61.25299292
41NME21.23285518
42EIF2AK31.20803523
43CCNB11.17000870
44PAK41.13127009
45ATM1.12547863
46BRD41.11714519
47CDK61.09634956
48MELK1.08315054
49EEF2K1.07033957
50TGFBR11.03840708
51STK30.99379941
52STK38L0.99353771
53CDK80.98379922
54MST40.96219415
55EIF2AK20.92929560
56CDK20.91272094
57LATS10.90189475
58PBK0.86877413
59WNK30.86515975
60PIM10.86463874
61TNIK0.79909672
62STK160.78626904
63* CDK10.77350054
64PLK20.75800003
65SCYL20.73645910
66BMPR1B0.68729270
67LATS20.64995722
68FLT30.62903977
69ALK0.62779059
70TESK10.60257593
71BCR0.57062864
72PAK10.56935338
73CSNK2A20.55050676
74CSNK2A10.54890915
75PRKCI0.54508553
76MTOR0.51254764
77CDK90.49804332
78YES10.49739260
79CDK30.49690199
80NEK90.48658162
81CLK10.47112312
82RPS6KA50.45693672
83UHMK10.45484628
84LRRK20.45279293
85CDK180.44418379
86PRKDC0.43882669
87BRAF0.43286803
88PKN20.43110496
89TAOK20.42501043
90CDK11A0.41291789
91CDK150.40866251
92AKT20.38994247
93CSNK1G10.37356892
94CDK140.36577768
95MAP3K30.34457440
96MARK30.33522114
97ERBB30.32471676
98DYRK20.32251276
99ERBB40.31992749
100MAP3K100.30331425
101PAK20.29649072
102CSNK1E0.29370860
103LMTK20.29223498
104MAPK140.28733774
105AKT10.28157242
106CSNK1D0.27269443
107CSNK1G30.26530454
108MET0.26204795
109NME10.26010935
110MINK10.25641852
111MAPK10.25373243
112TTN0.24814583
113ERBB20.24001328
114NUAK10.23921101
115STK390.23838428
116DYRK1B0.22880127
117FGFR10.21704681
118MAP2K30.21680388
119DMPK0.20977202
120RAF10.20544530
121GSK3B0.19727971
122PIM20.19499253
123SMG10.19495651
124PNCK0.19349854
125LIMK10.18278887
126CSNK1G20.15400871

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.80582691
2Mismatch repair_Homo sapiens_hsa034304.29047584
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.43672840
4Homologous recombination_Homo sapiens_hsa034403.43468894
5Cell cycle_Homo sapiens_hsa041103.33025981
6Spliceosome_Homo sapiens_hsa030403.23706676
7RNA transport_Homo sapiens_hsa030133.12853146
8Base excision repair_Homo sapiens_hsa034102.95925402
9Nucleotide excision repair_Homo sapiens_hsa034202.95053923
10Ribosome_Homo sapiens_hsa030102.88624692
11Fanconi anemia pathway_Homo sapiens_hsa034602.83463075
12RNA polymerase_Homo sapiens_hsa030202.75336778
13One carbon pool by folate_Homo sapiens_hsa006702.74026438
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27193839
15Basal transcription factors_Homo sapiens_hsa030222.20706172
16p53 signaling pathway_Homo sapiens_hsa041152.20307285
17Non-homologous end-joining_Homo sapiens_hsa034502.18813170
18Pyrimidine metabolism_Homo sapiens_hsa002402.17778088
19Proteasome_Homo sapiens_hsa030502.16563931
20mRNA surveillance pathway_Homo sapiens_hsa030152.00339845
21RNA degradation_Homo sapiens_hsa030181.91350042
22Systemic lupus erythematosus_Homo sapiens_hsa053221.67905420
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48759787
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29810432
25Oocyte meiosis_Homo sapiens_hsa041141.22844718
26Steroid biosynthesis_Homo sapiens_hsa001001.19616654
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19410335
28Viral carcinogenesis_Homo sapiens_hsa052031.18992582
29Epstein-Barr virus infection_Homo sapiens_hsa051691.15039616
30MicroRNAs in cancer_Homo sapiens_hsa052061.12388628
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11746645
32Purine metabolism_Homo sapiens_hsa002301.10950658
33Propanoate metabolism_Homo sapiens_hsa006401.10798933
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08975411
35Pyruvate metabolism_Homo sapiens_hsa006201.08274145
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01745533
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00696456
38Parkinsons disease_Homo sapiens_hsa050121.00279160
39Herpes simplex infection_Homo sapiens_hsa051681.00158760
40HTLV-I infection_Homo sapiens_hsa051660.93921170
41Small cell lung cancer_Homo sapiens_hsa052220.92130234
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89228304
43Fatty acid elongation_Homo sapiens_hsa000620.87407423
44Hippo signaling pathway_Homo sapiens_hsa043900.84447332
45Oxidative phosphorylation_Homo sapiens_hsa001900.84279259
46Basal cell carcinoma_Homo sapiens_hsa052170.83304710
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79790521
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79274566
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79148252
50TGF-beta signaling pathway_Homo sapiens_hsa043500.76847208
51Carbon metabolism_Homo sapiens_hsa012000.75790937
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73922925
53Thyroid cancer_Homo sapiens_hsa052160.69207069
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68352338
55Adherens junction_Homo sapiens_hsa045200.68306994
56Bladder cancer_Homo sapiens_hsa052190.67332021
57Alcoholism_Homo sapiens_hsa050340.67180414
58Selenocompound metabolism_Homo sapiens_hsa004500.65648614
59Antigen processing and presentation_Homo sapiens_hsa046120.64003888
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59027812
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58231641
62Colorectal cancer_Homo sapiens_hsa052100.56417617
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55286588
64Chronic myeloid leukemia_Homo sapiens_hsa052200.55276188
65Pentose phosphate pathway_Homo sapiens_hsa000300.53177872
66Hedgehog signaling pathway_Homo sapiens_hsa043400.53034366
67Notch signaling pathway_Homo sapiens_hsa043300.52271402
68Vitamin B6 metabolism_Homo sapiens_hsa007500.51069952
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.49482587
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.48922668
71Biosynthesis of amino acids_Homo sapiens_hsa012300.48899376
72Apoptosis_Homo sapiens_hsa042100.48093743
73Pathways in cancer_Homo sapiens_hsa052000.46634506
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44982744
75Hepatitis B_Homo sapiens_hsa051610.44454549
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42763515
77Legionellosis_Homo sapiens_hsa051340.42203531
78Alzheimers disease_Homo sapiens_hsa050100.40748769
79Viral myocarditis_Homo sapiens_hsa054160.40019191
80Folate biosynthesis_Homo sapiens_hsa007900.39530331
81Prostate cancer_Homo sapiens_hsa052150.37905248
82Melanoma_Homo sapiens_hsa052180.37682445
83Lysine degradation_Homo sapiens_hsa003100.37214006
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.36871942
85Tight junction_Homo sapiens_hsa045300.35747375
86Wnt signaling pathway_Homo sapiens_hsa043100.35548881
87Glutathione metabolism_Homo sapiens_hsa004800.35420161
88Metabolic pathways_Homo sapiens_hsa011000.33487023
89Shigellosis_Homo sapiens_hsa051310.32028027
90Proteoglycans in cancer_Homo sapiens_hsa052050.31913251
91FoxO signaling pathway_Homo sapiens_hsa040680.30737366
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30510260
93Fatty acid metabolism_Homo sapiens_hsa012120.30340087
94ECM-receptor interaction_Homo sapiens_hsa045120.28978188
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28122594
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.27185305
97Measles_Homo sapiens_hsa051620.27146333
98Pancreatic cancer_Homo sapiens_hsa052120.26294297
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26116586
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22969020
101Protein export_Homo sapiens_hsa030600.21701599
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21298741
103mTOR signaling pathway_Homo sapiens_hsa041500.21153780
104Endometrial cancer_Homo sapiens_hsa052130.21037265
105Influenza A_Homo sapiens_hsa051640.20706381
106HIF-1 signaling pathway_Homo sapiens_hsa040660.20703069
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20230268
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19737300
109Focal adhesion_Homo sapiens_hsa045100.19039465
110Non-small cell lung cancer_Homo sapiens_hsa052230.18980521
111Hematopoietic cell lineage_Homo sapiens_hsa046400.17324747
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16559560
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.15918740
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.15278551
115Huntingtons disease_Homo sapiens_hsa050160.14859030
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.14785123
117N-Glycan biosynthesis_Homo sapiens_hsa005100.14611651
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14526837
119Arachidonic acid metabolism_Homo sapiens_hsa005900.12245535
120Arginine and proline metabolism_Homo sapiens_hsa003300.12163414
121Renin-angiotensin system_Homo sapiens_hsa046140.11439530
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.09738558
123Sulfur relay system_Homo sapiens_hsa041220.08596149
124Gap junction_Homo sapiens_hsa045400.08166495
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.07573605
126Melanogenesis_Homo sapiens_hsa049160.06628621
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.03299643

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