ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of cGMP biosynthetic process (GO:0030828)	9.55382035
2	regulation of cGMP biosynthetic process (GO:0030826)	9.02135613
3	positive regulation of cGMP metabolic process (GO:0030825)	8.56417410
4	regulation of cGMP metabolic process (GO:0030823)	7.89122794
5	protein prenylation (GO:0018342)	6.90045818
6	prenylation (GO:0097354)	6.90045818
7	type B pancreatic cell proliferation (GO:0044342)	6.00519540
8	multi-organism reproductive behavior (GO:0044705)	5.97894925
9	histone H2A acetylation (GO:0043968)	5.88585103
10	cellular ketone body metabolic process (GO:0046950)	5.81775059
11	wound healing, spreading of epidermal cells (GO:0035313)	5.78174630
12	protein import into peroxisome matrix (GO:0016558)	5.66988180
13	type B pancreatic cell development (GO:0003323)	5.63792703
14	reproductive behavior (GO:0019098)	5.59828526
15	synapsis (GO:0007129)	5.34494148
16	phosphate ion transport (GO:0006817)	5.22824330
17	homeostasis of number of cells within a tissue (GO:0048873)	5.22517493
18	ketone body metabolic process (GO:1902224)	5.15407198
19	seminiferous tubule development (GO:0072520)	4.82408555
20	spermatid development (GO:0007286)	4.77301376
21	phosphorelay signal transduction system (GO:0000160)	4.63845186
22	histone H4-K12 acetylation (GO:0043983)	4.61775436
23	phosphate ion transmembrane transport (GO:0035435)	4.44567098
24	complement activation, alternative pathway (GO:0006957)	4.42594728
25	peptidyl-tyrosine autophosphorylation (GO:0038083)	4.15445146
26	acrosome reaction (GO:0007340)	4.07456988
27	carnitine shuttle (GO:0006853)	4.05289280
28	cellular sodium ion homeostasis (GO:0006883)	3.93077079
29	regulation of hippo signaling (GO:0035330)	3.86522980
30	urate metabolic process (GO:0046415)	3.83727395
31	glandular epithelial cell development (GO:0002068)	3.79795952
32	fatty acid transmembrane transport (GO:1902001)	3.78894241
33	regulation of RNA export from nucleus (GO:0046831)	3.70179034
34	response to lead ion (GO:0010288)	3.69369311
35	pentose metabolic process (GO:0019321)	3.58237881
36	respiratory chain complex IV assembly (GO:0008535)	3.56048626
37	negative regulation of cAMP-mediated signaling (GO:0043951)	3.53909809
38	fertilization (GO:0009566)	3.45746207
39	histone H3-K9 methylation (GO:0051567)	3.41026045
40	nephron tubule morphogenesis (GO:0072078)	3.36845846
41	nephron epithelium morphogenesis (GO:0072088)	3.36845846
42	response to parathyroid hormone (GO:0071107)	3.35661701
43	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.32403090
44	wound healing, spreading of cells (GO:0044319)	3.32027811
45	carnitine transmembrane transport (GO:1902603)	3.30833603
46	protein targeting to peroxisome (GO:0006625)	3.30693191
47	establishment of protein localization to peroxisome (GO:0072663)	3.30693191
48	protein localization to peroxisome (GO:0072662)	3.30693191
49	peristalsis (GO:0030432)	3.17381357
50	positive regulation of calcium ion import (GO:0090280)	3.16253986
51	sodium ion homeostasis (GO:0055078)	3.14546096
52	branched-chain amino acid catabolic process (GO:0009083)	3.14243335
53	positive regulation of action potential (GO:0045760)	3.13170523
54	positive regulation of cyclic nucleotide biosynthetic process (GO:0030804)	3.12315647
55	regulation of gene expression by genetic imprinting (GO:0006349)	3.11474970
56	multicellular organism reproduction (GO:0032504)	3.11454466
57	amino-acid betaine transport (GO:0015838)	3.02140826
58	carnitine transport (GO:0015879)	3.02140826
59	positive regulation of nucleotide biosynthetic process (GO:0030810)	3.01361774
60	positive regulation of purine nucleotide biosynthetic process (GO:1900373)	3.01361774
61	growth hormone receptor signaling pathway (GO:0060396)	2.98567008
62	peroxisomal transport (GO:0043574)	2.97708932
63	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.96973983
64	metanephric tubule development (GO:0072170)	2.94113164
65	metanephric nephron tubule development (GO:0072234)	2.94113164
66	behavioral response to nicotine (GO:0035095)	2.91595362
67	multi-organism behavior (GO:0051705)	2.88035476
68	response to growth hormone (GO:0060416)	2.87614556
69	positive regulation of histone H3-K4 methylation (GO:0051571)	2.87188639
70	germ cell development (GO:0007281)	2.84871886
71	branched-chain amino acid metabolic process (GO:0009081)	2.84737912
72	cornea development in camera-type eye (GO:0061303)	2.80871786
73	calcium ion-dependent exocytosis (GO:0017156)	2.80580227
74	histone H3-K9 modification (GO:0061647)	2.80358625
75	positive regulation of cyclic nucleotide metabolic process (GO:0030801)	2.79765922
76	negative regulation of Rho protein signal transduction (GO:0035024)	2.76892808
77	regulation of nucleobase-containing compound transport (GO:0032239)	2.76205702
78	negative regulation of cell-matrix adhesion (GO:0001953)	2.75911923
79	male meiosis I (GO:0007141)	2.71379741
80	cofactor catabolic process (GO:0051187)	2.69131344
81	adenosine metabolic process (GO:0046085)	2.68939880
82	cellular response to growth hormone stimulus (GO:0071378)	2.66879104
83	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.66190024
84	regulation of natural killer cell differentiation (GO:0032823)	2.66018146
85	glucosamine-containing compound catabolic process (GO:1901072)	2.65468691
86	phospholipid catabolic process (GO:0009395)	2.65194999
87	response to pheromone (GO:0019236)	2.64787447
88	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.64277898
89	detection of light stimulus involved in sensory perception (GO:0050962)	2.63558322
90	detection of light stimulus involved in visual perception (GO:0050908)	2.63558322
91	detection of bacterium (GO:0016045)	2.63527600
92	coenzyme catabolic process (GO:0009109)	2.62715778
93	rRNA transcription (GO:0009303)	2.60488747
94	metanephric nephron epithelium development (GO:0072243)	2.55826831
95	protein localization to microtubule (GO:0035372)	2.55536342
96	negative regulation of JAK-STAT cascade (GO:0046426)	2.55124962
97	cytochrome complex assembly (GO:0017004)	2.54149030
98	sulfation (GO:0051923)	2.53898137
99	mating behavior (GO:0007617)	19.8129193
100	genitalia morphogenesis (GO:0035112)	11.5619529

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	9.14066567
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	8.06255769
3	EZH2_22144423_ChIP-Seq_EOC_Human	7.02215880
4	GATA1_22025678_ChIP-Seq_K562_Human	5.60980087
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.30827546
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.27064297
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.87598782
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.62848741
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.26727289
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.13779144
11	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.94615576
12	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.88763183
13	ER_23166858_ChIP-Seq_MCF-7_Human	1.78919913
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.74821830
15	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.50913957
16	FUS_26573619_Chip-Seq_HEK293_Human	1.50547327
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.49934547
18	P300_19829295_ChIP-Seq_ESCs_Human	1.48906329
19	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.45107694
20	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.45081530
21	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40459271
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.39747580
23	DROSHA_22980978_ChIP-Seq_HELA_Human	1.39262591
24	VDR_22108803_ChIP-Seq_LS180_Human	1.38931125
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.38493057
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36323061
27	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.34955357
28	STAT3_23295773_ChIP-Seq_U87_Human	1.32634713
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.32405669
30	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29875402
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.23614239
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.22847374
33	HTT_18923047_ChIP-ChIP_STHdh_Human	1.21285595
34	TP53_18474530_ChIP-ChIP_U2OS_Human	1.20257008
35	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.18422146
36	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16806045
37	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.16749825
38	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.11576715
39	ERG_20517297_ChIP-Seq_VCAP_Human	1.11254835
40	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.05142412
41	RUNX2_22187159_ChIP-Seq_PCA_Human	1.04468154
42	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04377738
43	TCF4_23295773_ChIP-Seq_U87_Human	1.02782992
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.02396311
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02173151
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.02173151
47	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.01505999
48	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01393724
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.99991079
50	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.99817447
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.99455133
52	CJUN_26792858_Chip-Seq_BT549_Human	0.98058425
53	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.97502755
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97287349
55	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.97012466
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97004281
57	STAT1_17558387_ChIP-Seq_HELA_Human	0.96704748
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.96663051
59	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95494937
60	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.91060715
61	TCF4_22108803_ChIP-Seq_LS180_Human	0.90746262
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.89818133
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.89818133
64	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.88053563
65	NCOR_22424771_ChIP-Seq_293T_Human	0.86816804
66	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.86357933
67	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.86338390
68	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.85146532
69	AR_25329375_ChIP-Seq_VCAP_Human	0.85102327
70	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.84729362
71	STAT1_20625510_ChIP-Seq_HELA_Human	0.84548926
72	AR_20517297_ChIP-Seq_VCAP_Human	0.83523035
73	GATA3_26560356_Chip-Seq_TH1_Human	0.82785857
74	EWS_26573619_Chip-Seq_HEK293_Human	0.82590137
75	REST_21632747_ChIP-Seq_MESCs_Mouse	0.82022804
76	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.81655543
77	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.81363457
78	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.80655738
79	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.80449591
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.80432938
81	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.79145338
82	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.78690372
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.78558026
84	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.78040513
85	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.78039723
86	BCAT_22108803_ChIP-Seq_LS180_Human	0.78004567
87	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.77032912
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.76799377
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.76598411
90	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.76539806
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.75949471
92	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.75388654
93	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.74535933
94	SOX2_19829295_ChIP-Seq_ESCs_Human	0.74522335
95	NANOG_19829295_ChIP-Seq_ESCs_Human	0.74522335
96	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.74290634
97	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.74167191
98	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.73483367
99	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.73241264
100	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.72830067

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	8.39977060
2	MP0003787_abnormal_imprinting	7.97804162
3	MP0001502_abnormal_circadian_rhythm	4.81134686
4	MP0005646_abnormal_pituitary_gland	4.27341285
5	MP0009780_abnormal_chondrocyte_physiolo	3.86521216
6	MP0002332_abnormal_exercise_endurance	2.86125945
7	MP0002254_reproductive_system_inflammat	2.81642587
8	MP0005645_abnormal_hypothalamus_physiol	2.71481380
9	MP0002909_abnormal_adrenal_gland	2.69107800
10	MP0003121_genomic_imprinting	2.65367876
11	MP0003724_increased_susceptibility_to	2.56995596
12	MP0002837_dystrophic_cardiac_calcinosis	2.26565486
13	MP0005379_endocrine/exocrine_gland_phen	2.25458240
14	MP0000013_abnormal_adipose_tissue	2.21007479
15	MP0003123_paternal_imprinting	2.16891841
16	MP0002160_abnormal_reproductive_system	2.04129061
17	MP0002138_abnormal_hepatobiliary_system	1.90351120
18	MP0004130_abnormal_muscle_cell	1.83048432
19	MP0003045_fibrosis	1.62902960
20	MP0002163_abnormal_gland_morphology	1.59576272
21	MP0000569_abnormal_digit_pigmentation	1.54502631
22	MP0001501_abnormal_sleep_pattern	1.46790592
23	MP0004147_increased_porphyrin_level	1.44281827
24	MP0004381_abnormal_hair_follicle	1.42350005
25	MP0003136_yellow_coat_color	1.40812297
26	MP0005647_abnormal_sex_gland	1.38847659
27	MP0005551_abnormal_eye_electrophysiolog	1.38836804
28	MP0001764_abnormal_homeostasis	1.36857007
29	MP0005389_reproductive_system_phenotype	1.34597202
30	MP0002693_abnormal_pancreas_physiology	1.32697038
31	MP0000383_abnormal_hair_follicle	1.31504674
32	MP0003195_calcinosis	1.31164600
33	MP0000427_abnormal_hair_cycle	1.29558219
34	MP0004019_abnormal_vitamin_homeostasis	1.24707746
35	MP0003878_abnormal_ear_physiology	1.24411117
36	MP0005377_hearing/vestibular/ear_phenot	1.24411117
37	MP0001944_abnormal_pancreas_morphology	1.21590399
38	MP0000372_irregular_coat_pigmentation	1.14308528
39	MP0006072_abnormal_retinal_apoptosis	1.13418241
40	MP0002139_abnormal_hepatobiliary_system	1.10863266
41	MP0002735_abnormal_chemical_nociception	1.06515022
42	MP0002210_abnormal_sex_determination	1.05484779
43	MP0005266_abnormal_metabolism	1.04414262
44	MP0004270_analgesia	1.00874556
45	MP0000003_abnormal_adipose_tissue	1.00518721
46	MP0003698_abnormal_male_reproductive	0.99789060
47	MP0005360_urolithiasis	0.97294855
48	MP0002090_abnormal_vision	0.96540683
49	MP0009046_muscle_twitch	0.95078133
50	MP0004043_abnormal_pH_regulation	0.93057872
51	MP0005670_abnormal_white_adipose	0.90622634
52	MP0002132_abnormal_respiratory_system	0.90376926
53	MP0004215_abnormal_myocardial_fiber	0.89682703
54	MP0010678_abnormal_skin_adnexa	0.88419755
55	MP0005084_abnormal_gallbladder_morpholo	0.88305496
56	MP0002653_abnormal_ependyma_morphology	0.88027157
57	MP0001765_abnormal_ion_homeostasis	0.87701885
58	MP0004510_myositis	0.87568175
59	MP0002733_abnormal_thermal_nociception	0.84821763
60	MP0001929_abnormal_gametogenesis	0.83181784
61	MP0003690_abnormal_glial_cell	0.80717503
62	MP0001968_abnormal_touch/_nociception	0.80482622
63	MP0001545_abnormal_hematopoietic_system	0.79823717
64	MP0005397_hematopoietic_system_phenotyp	0.79823717
65	MP0000230_abnormal_systemic_arterial	0.79802466
66	MP0005332_abnormal_amino_acid	0.78523734
67	MP0005410_abnormal_fertilization	0.78294653
68	MP0008057_abnormal_DNA_replication	0.77875660
69	MP0004085_abnormal_heartbeat	0.77467571
70	MP0005310_abnormal_salivary_gland	0.77287104
71	MP0000647_abnormal_sebaceous_gland	0.75786900
72	MP0004484_altered_response_of	0.73892820
73	MP0005319_abnormal_enzyme/_coenzyme	0.73539290
74	MP0000631_abnormal_neuroendocrine_gland	0.73087789
75	MP0003953_abnormal_hormone_level	0.72348847
76	MP0001486_abnormal_startle_reflex	0.68540491
77	MP0001145_abnormal_male_reproductive	0.68329279
78	MP0009745_abnormal_behavioral_response	0.64333706
79	MP0002166_altered_tumor_susceptibility	0.63253901
80	MP0001243_abnormal_dermal_layer	0.62986648
81	MP0003633_abnormal_nervous_system	0.62575028
82	MP0001533_abnormal_skeleton_physiology	0.62571681
83	MP0001348_abnormal_lacrimal_gland	0.62328023
84	MP0005253_abnormal_eye_physiology	0.61852664
85	MP0005195_abnormal_posterior_eye	0.59204941
86	MP0000462_abnormal_digestive_system	0.58889148
87	MP0000653_abnormal_sex_gland	0.57974349
88	MP0002078_abnormal_glucose_homeostasis	0.55831510
89	MP0002557_abnormal_social/conspecific_i	0.55163273
90	MP0002971_abnormal_brown_adipose	0.54806238
91	MP0004142_abnormal_muscle_tone	0.53720528
92	MP0004145_abnormal_muscle_electrophysio	0.53175952
93	MP0001970_abnormal_pain_threshold	0.52584686
94	MP0005376_homeostasis/metabolism_phenot	0.51274304
95	MP0008875_abnormal_xenobiotic_pharmacok	0.49888080
96	MP0004782_abnormal_surfactant_physiolog	0.49139074
97	MP0009785_altered_susceptibility_to	0.48615404
98	MP0002064_seizures	0.48301010
99	MP0000639_abnormal_adrenal_gland	0.48062455
100	MP0002063_abnormal_learning/memory/cond	0.47593299

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Neonatal hypoglycemia (HP:0001998)	5.34864558
2	Recurrent gram-negative bacterial infections (HP:0005420)	4.91124507
3	Pancreatic cysts (HP:0001737)	4.67910123
4	Posterior subcapsular cataract (HP:0007787)	4.25457472
5	Infertility (HP:0000789)	4.23620633
6	Mitral stenosis (HP:0001718)	4.19828639
7	Abnormality of midbrain morphology (HP:0002418)	4.14364702
8	Molar tooth sign on MRI (HP:0002419)	4.14364702
9	True hermaphroditism (HP:0010459)	3.88711722
10	Cystic liver disease (HP:0006706)	3.83472588
11	Pancreatic fibrosis (HP:0100732)	3.81057669
12	3-Methylglutaconic aciduria (HP:0003535)	3.77791521
13	Urethral obstruction (HP:0000796)	3.75270842
14	Pheochromocytoma (HP:0002666)	3.71378832
15	Microretrognathia (HP:0000308)	3.69067552
16	Pendular nystagmus (HP:0012043)	3.68363084
17	Attenuation of retinal blood vessels (HP:0007843)	3.57219584
18	Generalized aminoaciduria (HP:0002909)	3.55524233
19	Congenital sensorineural hearing impairment (HP:0008527)	3.47725619
20	Bifid tongue (HP:0010297)	3.45675764
21	Lip pit (HP:0100267)	3.45377223
22	Ketosis (HP:0001946)	3.39743413
23	Complement deficiency (HP:0004431)	3.35986702
24	Fetal akinesia sequence (HP:0001989)	3.26858721
25	Severe visual impairment (HP:0001141)	3.24012056
26	Congenital stationary night blindness (HP:0007642)	3.23242852
27	Hyperglycemia (HP:0003074)	3.18951434
28	Neoplasm of the heart (HP:0100544)	3.11344316
29	Ketoacidosis (HP:0001993)	3.02642227
30	Large eyes (HP:0001090)	2.97794727
31	Neuroendocrine neoplasm (HP:0100634)	2.96895005
32	Depressed nasal tip (HP:0000437)	2.87030272
33	Furrowed tongue (HP:0000221)	2.84616081
34	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.84407222
35	Oligodontia (HP:0000677)	2.77481636
36	Proximal tubulopathy (HP:0000114)	2.72215864
37	Broad alveolar ridges (HP:0000187)	2.67900035
38	Heterotopia (HP:0002282)	2.67649539
39	Horizontal nystagmus (HP:0000666)	2.67264259
40	Hyperventilation (HP:0002883)	2.65782391
41	Azoospermia (HP:0000027)	2.50650348
42	Myokymia (HP:0002411)	2.49028313
43	Hyperkalemia (HP:0002153)	2.47160145
44	Neoplasm of the peripheral nervous system (HP:0100007)	2.46961048
45	Bony spicule pigmentary retinopathy (HP:0007737)	2.41428334
46	Central scotoma (HP:0000603)	2.40732613
47	Spontaneous abortion (HP:0005268)	2.36636659
48	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36483021
49	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.35365451
50	Type 2 muscle fiber atrophy (HP:0003554)	2.34102406
51	Intellectual disability, progressive (HP:0006887)	2.33591370
52	Abnormality of the sella turcica (HP:0002679)	2.30278203
53	Milia (HP:0001056)	2.28539476
54	Abnormality of complement system (HP:0005339)	2.27340285
55	Flat occiput (HP:0005469)	2.21565399
56	Acute lymphatic leukemia (HP:0006721)	2.17671907
57	Brushfield spots (HP:0001088)	2.14118523
58	Optic nerve hypoplasia (HP:0000609)	2.14101018
59	Epiphyseal stippling (HP:0010655)	2.12854306
60	Nonprogressive disorder (HP:0003680)	2.12240905
61	Akinesia (HP:0002304)	2.11230766
62	Neoplasm of the oral cavity (HP:0100649)	2.10592539
63	Thoracolumbar scoliosis (HP:0002944)	2.10339855
64	Abnormality of proline metabolism (HP:0010907)	2.09278190
65	Hydroxyprolinuria (HP:0003080)	2.09278190
66	Hamartoma of the eye (HP:0010568)	2.09255073
67	Prolonged neonatal jaundice (HP:0006579)	2.09119080
68	Impaired smooth pursuit (HP:0007772)	2.09075967
69	Abnormality of chloride homeostasis (HP:0011422)	2.08245925
70	Intestinal atresia (HP:0011100)	2.06743466
71	Abnormal spermatogenesis (HP:0008669)	2.06667946
72	Gaze-evoked nystagmus (HP:0000640)	2.06456881
73	Abnormal rod and cone electroretinograms (HP:0008323)	2.01500709
74	Bile duct proliferation (HP:0001408)	2.00865603
75	Abnormal biliary tract physiology (HP:0012439)	2.00865603
76	Subcapsular cataract (HP:0000523)	1.96585469
77	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.95892169
78	Abnormality of alanine metabolism (HP:0010916)	1.95892169
79	Hyperalaninemia (HP:0003348)	1.95892169
80	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.95666320
81	Breech presentation (HP:0001623)	1.92723989
82	Abnormality of vitamin B metabolism (HP:0004340)	1.87540924
83	Truncal obesity (HP:0001956)	1.86634517
84	Sclerocornea (HP:0000647)	1.86255575
85	Meningioma (HP:0002858)	1.85900622
86	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.84154937
87	Popliteal pterygium (HP:0009756)	1.82254427
88	Muscle fiber atrophy (HP:0100295)	1.80353461
89	Abnormal albumin level (HP:0012116)	1.79366141
90	Hypoalbuminemia (HP:0003073)	1.79366141
91	Nephronophthisis (HP:0000090)	1.78765654
92	Glycosuria (HP:0003076)	1.78485656
93	Abnormality of urine glucose concentration (HP:0011016)	1.78485656
94	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.77740538
95	Cone-rod dystrophy (HP:0000548)	1.77028872
96	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.75115229
97	Hamartoma (HP:0010566)	1.74730187
98	Flat face (HP:0012368)	1.73225092
99	Dyschromatopsia (HP:0007641)	1.70911386
100	Increased corneal curvature (HP:0100692)	1.70665027

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.06881710
2	CDK12	4.47794942
3	MAP3K12	4.18965663
4	CDK19	3.93356202
5	MST4	3.61458531
6	NTRK3	3.56792883
7	MUSK	3.54325118
8	EPHA3	2.80711921
9	BRD4	2.54427592
10	ADRBK2	2.52438204
11	PIK3CG	2.25689219
12	MAP3K5	2.20370329
13	TNK2	2.11646549
14	EPHB1	2.07867498
15	PRKD3	1.91814652
16	FGFR4	1.69874231
17	STK38L	1.67611418
18	PHKG2	1.54873101
19	PHKG1	1.54873101
20	TXK	1.43173232
21	BUB1	1.43050212
22	FER	1.33729693
23	MAP3K11	1.30586041
24	RET	1.27766344
25	MOS	1.25101666
26	IRAK1	1.21006900
27	RPS6KB2	1.16681018
28	GRK7	1.14119599
29	ZAK	1.13787340
30	MAP2K3	1.10152259
31	MAP3K1	1.09566165
32	PRKG2	1.03416937
33	WNK4	1.01891338
34	PTK2B	0.98885537
35	EPHA4	0.93873734
36	FGFR3	0.93255347
37	FGFR2	0.91288530
38	DYRK1B	0.88643484
39	TRPM7	0.87630662
40	DAPK2	0.87025656
41	MAP2K4	0.86765708
42	TYRO3	0.83468334
43	PRKG1	0.82246527
44	OXSR1	0.81069090
45	ARAF	0.80816880
46	MAP3K3	0.78613394
47	PINK1	0.77225467
48	TAOK3	0.72516492
49	CDK9	0.64965252
50	MAPKAPK3	0.64844311
51	RPS6KA2	0.64488944
52	IKBKB	0.63980849
53	STK39	0.63791538
54	PRKACB	0.63688153
55	ACVR1B	0.63020961
56	NLK	0.61708549
57	MELK	0.61216160
58	TRIM28	0.61043796
59	RPS6KB1	0.58390492
60	STK3	0.55206632
61	DYRK1A	0.54325493
62	PRKCE	0.54100902
63	AURKA	0.51110381
64	PDK1	0.50154850
65	GRK5	0.49782069
66	NTRK2	0.47211485
67	PKN1	0.43759937
68	PDPK1	0.41106829
69	CAMK1	0.40722327
70	SGK1	0.39637453
71	ADRBK1	0.39549539
72	SIK3	0.38285609
73	PRKCG	0.38002282
74	PRKD2	0.36738235
75	STK38	0.35907992
76	LATS1	0.35389716
77	SIK2	0.35245662
78	MAP2K6	0.34459238
79	GRK1	0.32814229
80	ALK	0.31792945
81	PAK2	0.31475855
82	HCK	0.30469283
83	INSRR	0.29330919
84	CAMK2A	0.28942905
85	TGFBR2	0.27706229
86	MAP3K7	0.27260059
87	PRKAA1	0.27236401
88	DDR2	0.26496809
89	KSR1	0.25451925
90	BMPR1B	0.25029272
91	MAPK8	0.24348858
92	MAP2K1	0.24188102
93	CASK	0.24057025
94	RPS6KA5	0.23747335
95	STK4	0.23058621
96	STK11	0.22599246
97	CHEK1	0.22454630
98	PRKACA	0.22244596
99	MAPK4	0.20540824
100	RPS6KA3	0.20496299

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.19833179
2	Selenocompound metabolism_Homo sapiens_hsa00450	4.00093178
3	Sulfur metabolism_Homo sapiens_hsa00920	3.62941754
4	Circadian entrainment_Homo sapiens_hsa04713	3.33933112
5	Phototransduction_Homo sapiens_hsa04744	3.09123371
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.70568886
7	Butanoate metabolism_Homo sapiens_hsa00650	2.69253167
8	RNA polymerase_Homo sapiens_hsa03020	2.50058078
9	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.38602240
10	Renin-angiotensin system_Homo sapiens_hsa04614	2.32235662
11	One carbon pool by folate_Homo sapiens_hsa00670	2.07652773
12	Olfactory transduction_Homo sapiens_hsa04740	1.91114433
13	Taste transduction_Homo sapiens_hsa04742	1.79634669
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.74936346
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56105090
16	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.55439358
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.55396743
18	Circadian rhythm_Homo sapiens_hsa04710	1.51609061
19	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.46498032
20	Retinol metabolism_Homo sapiens_hsa00830	1.43514664
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.39928070
22	GABAergic synapse_Homo sapiens_hsa04727	1.37583138
23	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.37412845
24	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.37144944
25	Propanoate metabolism_Homo sapiens_hsa00640	1.36796974
26	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.35078809
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.34831865
28	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.34624231
29	Prion diseases_Homo sapiens_hsa05020	1.33481659
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.29190320
31	Morphine addiction_Homo sapiens_hsa05032	1.21369375
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.20855483
33	Complement and coagulation cascades_Homo sapiens_hsa04610	1.19426587
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.15194756
35	Insulin secretion_Homo sapiens_hsa04911	1.14075866
36	Linoleic acid metabolism_Homo sapiens_hsa00591	1.10678653
37	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.08388602
38	Homologous recombination_Homo sapiens_hsa03440	1.08153570
39	Caffeine metabolism_Homo sapiens_hsa00232	1.06747579
40	Folate biosynthesis_Homo sapiens_hsa00790	0.99812411
41	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.99371368
42	AMPK signaling pathway_Homo sapiens_hsa04152	0.98094617
43	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.97414619
44	Salivary secretion_Homo sapiens_hsa04970	0.93648967
45	Fatty acid degradation_Homo sapiens_hsa00071	0.92652893
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92228211
47	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.88498044
48	Serotonergic synapse_Homo sapiens_hsa04726	0.84494818
49	Nicotine addiction_Homo sapiens_hsa05033	0.83825188
50	Sulfur relay system_Homo sapiens_hsa04122	0.83388201
51	Glucagon signaling pathway_Homo sapiens_hsa04922	0.80379666
52	Renin secretion_Homo sapiens_hsa04924	0.79962309
53	Insulin resistance_Homo sapiens_hsa04931	0.79564908
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.77659757
55	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.72276442
56	Glutamatergic synapse_Homo sapiens_hsa04724	0.71861618
57	Cardiac muscle contraction_Homo sapiens_hsa04260	0.71036932
58	FoxO signaling pathway_Homo sapiens_hsa04068	0.65020693
59	Alcoholism_Homo sapiens_hsa05034	0.64632831
60	Type II diabetes mellitus_Homo sapiens_hsa04930	0.64601280
61	Purine metabolism_Homo sapiens_hsa00230	0.64391677
62	Peroxisome_Homo sapiens_hsa04146	0.62071362
63	Nitrogen metabolism_Homo sapiens_hsa00910	0.60744491
64	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.59833271
65	ABC transporters_Homo sapiens_hsa02010	0.58582331
66	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.57818211
67	Calcium signaling pathway_Homo sapiens_hsa04020	0.55593269
68	Arginine biosynthesis_Homo sapiens_hsa00220	0.55389605
69	Cholinergic synapse_Homo sapiens_hsa04725	0.55351562
70	Protein export_Homo sapiens_hsa03060	0.54956536
71	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.53400800
72	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.52897992
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.52476122
74	cAMP signaling pathway_Homo sapiens_hsa04024	0.51371196
75	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.51018849
76	Cocaine addiction_Homo sapiens_hsa05030	0.50913876
77	Type I diabetes mellitus_Homo sapiens_hsa04940	0.47326059
78	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.47112408
79	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.46138456
80	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.45419989
81	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.44198368
82	African trypanosomiasis_Homo sapiens_hsa05143	0.44155629
83	Basal transcription factors_Homo sapiens_hsa03022	0.44023446
84	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.43570475
85	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.43375116
86	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.42123038
87	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.41525711
88	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.41045650
89	Chemical carcinogenesis_Homo sapiens_hsa05204	0.40757706
90	Dopaminergic synapse_Homo sapiens_hsa04728	0.39413989
91	Protein digestion and absorption_Homo sapiens_hsa04974	0.35070024
92	Ether lipid metabolism_Homo sapiens_hsa00565	0.32195646
93	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.31166787
94	Insulin signaling pathway_Homo sapiens_hsa04910	0.30864978
95	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.29773327
96	Pyrimidine metabolism_Homo sapiens_hsa00240	0.29555773
97	Mineral absorption_Homo sapiens_hsa04978	0.27959956
98	mTOR signaling pathway_Homo sapiens_hsa04150	0.27280919
99	Pancreatic secretion_Homo sapiens_hsa04972	0.27151993
100	Lysine degradation_Homo sapiens_hsa00310	0.25613214

CKAP2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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