CKAP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)5.89287635
2protein heterotrimerization (GO:0070208)5.55157299
3chondrocyte proliferation (GO:0035988)5.32063361
4endodermal cell differentiation (GO:0035987)4.99303765
5bone trabecula formation (GO:0060346)4.72325581
6hemidesmosome assembly (GO:0031581)4.44702040
7skin morphogenesis (GO:0043589)4.39704923
8cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.14147532
9collagen metabolic process (GO:0032963)4.07028876
10basement membrane organization (GO:0071711)4.01917375
11sequestering of extracellular ligand from receptor (GO:0035581)4.00324699
12collagen catabolic process (GO:0030574)3.99020440
13peptidyl-proline hydroxylation (GO:0019511)3.96073271
14heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.84742427
15chondrocyte development (GO:0002063)3.78551159
16multicellular organismal macromolecule metabolic process (GO:0044259)3.76229312
17polarized epithelial cell differentiation (GO:0030859)3.72682258
18multicellular organismal catabolic process (GO:0044243)3.62400712
19type B pancreatic cell proliferation (GO:0044342)3.62052264
20neuron projection extension involved in neuron projection guidance (GO:1902284)3.60034208
21axon extension involved in axon guidance (GO:0048846)3.60034208
22wound healing, spreading of epidermal cells (GO:0035313)3.57204801
23extracellular matrix disassembly (GO:0022617)3.57056105
24negative regulation of fatty acid transport (GO:2000192)3.56887682
25regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.56459342
26paraxial mesoderm development (GO:0048339)3.54635578
27multicellular organismal metabolic process (GO:0044236)3.50160008
28planar cell polarity pathway involved in neural tube closure (GO:0090179)3.49751773
29protein localization to endosome (GO:0036010)3.47645541
30protein hydroxylation (GO:0018126)3.47413756
31hippo signaling (GO:0035329)3.46807785
32positive regulation of endothelial cell apoptotic process (GO:2000353)3.41668689
33mesodermal cell differentiation (GO:0048333)3.39732961
34mesenchymal-epithelial cell signaling (GO:0060638)3.36623401
35cell adhesion mediated by integrin (GO:0033627)3.34795242
36regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.33256963
37dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.31546046
38endocardial cushion development (GO:0003197)3.29876586
39maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.27096508
40epithelial cell-cell adhesion (GO:0090136)3.25246476
41extracellular matrix assembly (GO:0085029)3.21259831
42positive regulation of epithelial to mesenchymal transition (GO:0010718)3.19412288
43adhesion of symbiont to host cell (GO:0044650)3.17664371
44virion attachment to host cell (GO:0019062)3.17664371
45dermatan sulfate biosynthetic process (GO:0030208)3.16908221
46protein retention in ER lumen (GO:0006621)3.15883768
47craniofacial suture morphogenesis (GO:0097094)3.15551282
48heparan sulfate proteoglycan metabolic process (GO:0030201)3.13860893
49outer ear morphogenesis (GO:0042473)3.12395581
50negative regulation of smooth muscle cell migration (GO:0014912)3.11172069
51negative regulation of chondrocyte differentiation (GO:0032331)3.10577199
52hypotonic response (GO:0006971)3.08703474
53stress fiber assembly (GO:0043149)3.06109011
54regulation of plasminogen activation (GO:0010755)3.06006887
55regulation of SMAD protein import into nucleus (GO:0060390)3.05395252
56negative regulation of axon extension involved in axon guidance (GO:0048843)3.04906812
57Golgi transport vesicle coating (GO:0048200)3.03657123
58COPI coating of Golgi vesicle (GO:0048205)3.03657123
59keratan sulfate catabolic process (GO:0042340)3.03226873
60metanephric mesenchyme development (GO:0072075)2.99684577
61tooth mineralization (GO:0034505)2.96008358
62regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.95962906
63retina vasculature morphogenesis in camera-type eye (GO:0061299)2.95312750
64vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.94911309
65blood vessel endothelial cell migration (GO:0043534)2.92693326
66establishment of apical/basal cell polarity (GO:0035089)2.91999177
67barbed-end actin filament capping (GO:0051016)2.91640589
68adhesion of symbiont to host (GO:0044406)2.90701100
69embryonic cranial skeleton morphogenesis (GO:0048701)2.89598856
70wound healing, spreading of cells (GO:0044319)2.88873047
71plasma membrane repair (GO:0001778)2.88798567
72negative regulation of cartilage development (GO:0061037)2.86228540
73G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.86053915
74substrate adhesion-dependent cell spreading (GO:0034446)2.84619960
75notochord development (GO:0030903)2.83597091
76kidney mesenchyme development (GO:0072074)2.83540509
77cochlea morphogenesis (GO:0090103)2.82394028
78dermatan sulfate metabolic process (GO:0030205)2.82121444
79positive regulation of SMAD protein import into nucleus (GO:0060391)2.81150003
80regulation of extracellular matrix disassembly (GO:0010715)2.79903544
81protein localization to cell surface (GO:0034394)2.79427264
82cell-substrate adherens junction assembly (GO:0007045)2.79354990
83focal adhesion assembly (GO:0048041)2.79354990
84endothelial cell morphogenesis (GO:0001886)2.78267039
85cell migration involved in heart development (GO:0060973)2.78229592
86venous blood vessel morphogenesis (GO:0048845)2.75794728
87hyaluronan catabolic process (GO:0030214)2.72588797
88negative regulation of embryonic development (GO:0045992)2.71382943
89cellular response to vitamin D (GO:0071305)2.70619824
90lymphangiogenesis (GO:0001946)2.69591039
91regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.69585430
92chondroitin sulfate biosynthetic process (GO:0030206)2.68699942
93extracellular matrix organization (GO:0030198)2.66857360
94proteoglycan biosynthetic process (GO:0030166)2.66252414
95apoptotic cell clearance (GO:0043277)2.66026036
96extracellular structure organization (GO:0043062)2.65909454
97embryonic skeletal joint morphogenesis (GO:0060272)2.65906425
98regulation of heart morphogenesis (GO:2000826)2.63249255
99regulation of cartilage development (GO:0061035)2.62674456
100proteoglycan metabolic process (GO:0006029)2.61703810
101negative regulation of osteoblast proliferation (GO:0033689)2.61673616
102muscle cell migration (GO:0014812)2.60712367
103vascular endothelial growth factor signaling pathway (GO:0038084)2.60545232
104non-canonical Wnt signaling pathway (GO:0035567)2.59630764
105regulation of hippo signaling (GO:0035330)2.59028138
106cranial suture morphogenesis (GO:0060363)2.58919824
107positive regulation of blood vessel endothelial cell migration (GO:0043536)2.58556650
108regulation of tight junction assembly (GO:2000810)2.58392064
109regulation of early endosome to late endosome transport (GO:2000641)2.58271492
110extracellular negative regulation of signal transduction (GO:1900116)2.57713725
111extracellular regulation of signal transduction (GO:1900115)2.57713725
112cell-substrate junction assembly (GO:0007044)2.57322255
113cell migration involved in sprouting angiogenesis (GO:0002042)2.57138826
114extracellular fibril organization (GO:0043206)2.56856056
115positive regulation of osteoblast proliferation (GO:0033690)2.53892189
116adherens junction assembly (GO:0034333)2.52992234
117Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.52714999
118positive regulation of stem cell differentiation (GO:2000738)2.51618947
119heterochromatin organization (GO:0070828)2.50898958
120middle ear morphogenesis (GO:0042474)2.49190293
121positive regulation of cartilage development (GO:0061036)2.48449654
122glomerular basement membrane development (GO:0032836)2.48358315
123negative regulation of catenin import into nucleus (GO:0035414)2.48302063
124establishment of monopolar cell polarity (GO:0061162)2.47707838
125establishment or maintenance of monopolar cell polarity (GO:0061339)2.47707838
126endochondral ossification (GO:0001958)2.47591849
127replacement ossification (GO:0036075)2.47591849
128regulation of establishment of planar polarity (GO:0090175)2.46893670
129fibril organization (GO:0097435)2.46794556
130cellular response to vitamin (GO:0071295)2.45359395
131substrate-dependent cell migration (GO:0006929)2.44766064
132epithelial to mesenchymal transition (GO:0001837)2.44367440
133insulin-like growth factor receptor signaling pathway (GO:0048009)2.43853226
134mesenchyme development (GO:0060485)2.43746122
135regulation of gastrulation (GO:0010470)2.41482186
136negative regulation of cell fate specification (GO:0009996)2.40834472
137regulation of chondrocyte differentiation (GO:0032330)2.39878132
138regulation of cell fate specification (GO:0042659)2.38922029

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.09029763
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.04736294
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.01400579
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.90455462
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.11884990
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.08564551
7E2F7_22180533_ChIP-Seq_HELA_Human2.96894419
8RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.93429502
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.54756050
10CLOCK_20551151_ChIP-Seq_293T_Human2.47918259
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.39916302
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.38094394
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.33723515
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.30718498
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.13875065
16BRD4_25478319_ChIP-Seq_HGPS_Human2.12582495
17* ELK3_25401928_ChIP-Seq_HUVEC_Human2.12213917
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.09259784
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.03919592
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.02119046
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.02052004
22CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.95538507
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.93838177
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92515888
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.81245682
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.80350554
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.72344977
28CJUN_26792858_Chip-Seq_BT549_Human1.71683245
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.71529483
30ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.70804611
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70789849
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64694119
33SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.63683909
34SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.63683909
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.62667488
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.62235660
37* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.61863525
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61843587
39TP53_22127205_ChIP-Seq_IMR90_Human1.61507784
40AR_21909140_ChIP-Seq_LNCAP_Human1.61229758
41* ATF3_27146783_Chip-Seq_COLON_Human1.58211211
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.58204094
43TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56527745
44* UBF1/2_26484160_Chip-Seq_HMECs_Human1.51333683
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49589915
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48768884
47TP53_20018659_ChIP-ChIP_R1E_Mouse1.48311353
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.47561655
49TP53_18474530_ChIP-ChIP_U2OS_Human1.43700152
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42844870
51MYC_22102868_ChIP-Seq_BL_Human1.42810674
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41346652
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41346652
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41147467
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39073413
56* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.37933783
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37209679
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36451744
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36132722
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35971192
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35717853
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.35154747
63* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34379408
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.33452437
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.33452437
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.33452437
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30414436
68SMC3_22415368_ChIP-Seq_MEFs_Mouse1.30376236
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30349377
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.29954902
71SMC1_22415368_ChIP-Seq_MEFs_Mouse1.29549626
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28638030
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28410482
74* KDM2B_26808549_Chip-Seq_K562_Human1.28035079
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27701883
76SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27228907
77VDR_21846776_ChIP-Seq_THP-1_Human1.27018262
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.25618982
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25578357
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24877165
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24418758
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23948990
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23540075
84* RACK7_27058665_Chip-Seq_MCF-7_Human1.23389275
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23303356
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23230092
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23186433
88KDM2B_26808549_Chip-Seq_DND41_Human1.22477098
89MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.21151044
90ZNF263_19887448_ChIP-Seq_K562_Human1.20904304
91SA1_22415368_ChIP-Seq_MEFs_Mouse1.20766511
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20623601
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20623601
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20533062
95TP53_16413492_ChIP-PET_HCT116_Human1.16434263
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15321779
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14361955
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14346614
99TP53_23651856_ChIP-Seq_MEFs_Mouse1.14332525
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13639172
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13418743
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13102230
103* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.12866584
104ESR1_21235772_ChIP-Seq_MCF-7_Human1.12834413
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09192968
106NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07108222
107P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06787709
108ISL1_27105846_Chip-Seq_CPCs_Mouse1.05963917
109SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05291124
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03301554
111PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02963302
112STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02617546
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02167670
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02071024
115TCF7_22412390_ChIP-Seq_EML_Mouse1.01940670
116ELK1_22589737_ChIP-Seq_MCF10A_Human1.01323096
117LXR_22292898_ChIP-Seq_THP-1_Human1.01132145
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01125492
119KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01039271
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01003437
121* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00126941
122EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99944868
123NANOG_16153702_ChIP-ChIP_HESCs_Human0.99648990
124SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98923764
125KDM2B_26808549_Chip-Seq_JURKAT_Human0.97397935
126TBX20_22080862_ChIP-Seq_HEART_Mouse0.96770579
127TBX20_22328084_ChIP-Seq_HEART_Mouse0.96770579
128SOX2_20726797_ChIP-Seq_SW620_Human0.96472952
129NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95187891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.37871585
2MP0005503_abnormal_tendon_morphology4.41855642
3MP0005275_abnormal_skin_tensile4.10647534
4MP0003705_abnormal_hypodermis_morpholog3.54651370
5MP0003279_aneurysm3.27536518
6MP0004272_abnormal_basement_membrane3.13955676
7MP0005623_abnormal_meninges_morphology2.95952635
8MP0006054_spinal_hemorrhage2.53120405
9MP0001958_emphysema2.41226394
10MP0010030_abnormal_orbit_morphology2.34149782
11MP0003566_abnormal_cell_adhesion2.23129121
12MP0009384_cardiac_valve_regurgitation2.17306429
13MP0005508_abnormal_skeleton_morphology2.10839738
14MP0010352_gastrointestinal_tract_polyps2.09892497
15MP0003385_abnormal_body_wall1.96748836
16MP0005257_abnormal_intraocular_pressure1.96471515
17MP0009250_abnormal_appendicular_skeleto1.94961562
18MP0005023_abnormal_wound_healing1.88559675
19MP0003950_abnormal_plasma_membrane1.82363479
20MP0002282_abnormal_trachea_morphology1.75005623
21MP0009053_abnormal_anal_canal1.74322508
22MP0004858_abnormal_nervous_system1.66900896
23MP0005076_abnormal_cell_differentiation1.64220966
24MP0003091_abnormal_cell_migration1.56606112
25MP0002060_abnormal_skin_morphology1.56201016
26MP0000733_abnormal_muscle_development1.52613160
27MP0002896_abnormal_bone_mineralization1.50862100
28MP0003941_abnormal_skin_development1.50162496
29MP0009780_abnormal_chondrocyte_physiolo1.46831820
30MP0003942_abnormal_urinary_system1.45403690
31MP0003283_abnormal_digestive_organ1.44330524
32MP0001542_abnormal_bone_strength1.43447613
33MP0004134_abnormal_chest_morphology1.42633892
34MP0003123_paternal_imprinting1.38077176
35MP0000163_abnormal_cartilage_morphology1.35014749
36MP0000049_abnormal_middle_ear1.34385708
37MP0000767_abnormal_smooth_muscle1.32280453
38MP0002932_abnormal_joint_morphology1.30954647
39MP0002877_abnormal_melanocyte_morpholog1.30778378
40MP0000428_abnormal_craniofacial_morphol1.30745232
41MP0005390_skeleton_phenotype1.29008766
42MP0002108_abnormal_muscle_morphology1.28324544
43MP0003115_abnormal_respiratory_system1.28257888
44MP0002115_abnormal_skeleton_extremities1.28025408
45MP0003755_abnormal_palate_morphology1.26864689
46MP0000013_abnormal_adipose_tissue1.26765590
47MP0002933_joint_inflammation1.26602875
48MP0000537_abnormal_urethra_morphology1.26144614
49MP0000534_abnormal_ureter_morphology1.25640098
50MP0001299_abnormal_eye_distance/1.24675798
51MP0002113_abnormal_skeleton_development1.21923206
52MP0005197_abnormal_uvea_morphology1.19879419
53MP0001243_abnormal_dermal_layer1.18745058
54MP0003122_maternal_imprinting1.18315139
55MP0010368_abnormal_lymphatic_system1.18281239
56MP0004197_abnormal_fetal_growth/weight/1.12769208
57MP0003935_abnormal_craniofacial_develop1.10312239
58MP0002295_abnormal_pulmonary_circulatio1.09848002
59MP0005409_darkened_coat_color1.09341354
60MP0000432_abnormal_head_morphology1.08966536
61MP0005595_abnormal_vascular_smooth1.08109603
62MP0003937_abnormal_limbs/digits/tail_de1.06536988
63MP0002116_abnormal_craniofacial_bone1.06274545
64MP0000762_abnormal_tongue_morphology1.05913496
65MP0002109_abnormal_limb_morphology1.03688170
66MP0002111_abnormal_tail_morphology1.03215420
67MP0009278_abnormal_bone_marrow1.02509066
68MP0000516_abnormal_urinary_system1.00025738
69MP0005367_renal/urinary_system_phenotyp1.00025738
70MP0003567_abnormal_fetal_cardiomyocyte0.99597062
71MP0002089_abnormal_postnatal_growth/wei0.98721308
72MP0002249_abnormal_larynx_morphology0.98180365
73MP0003300_gastrointestinal_ulcer0.98163850
74MP0004808_abnormal_hematopoietic_stem0.96684076
75MP0002697_abnormal_eye_size0.96417619
76MP0001915_intracranial_hemorrhage0.95606031
77MP0002254_reproductive_system_inflammat0.95411481
78MP0002925_abnormal_cardiovascular_devel0.94070904
79MP0000750_abnormal_muscle_regeneration0.91029153
80MP0000467_abnormal_esophagus_morphology0.88784768
81MP0001879_abnormal_lymphatic_vessel0.88387127
82MP0001348_abnormal_lacrimal_gland0.87090569
83MP0005164_abnormal_response_to0.85518314
84MP0002233_abnormal_nose_morphology0.85430655
85MP0001614_abnormal_blood_vessel0.84201304
86MP0009840_abnormal_foam_cell0.84013721
87MP0002084_abnormal_developmental_patter0.83226970
88MP0003119_abnormal_digestive_system0.83206910
89MP0002114_abnormal_axial_skeleton0.83107403
90MP0000751_myopathy0.82573879
91MP0001533_abnormal_skeleton_physiology0.82015485
92MP0003795_abnormal_bone_structure0.81979976
93MP0002085_abnormal_embryonic_tissue0.81478015
94MP0000003_abnormal_adipose_tissue0.80500005
95MP0002128_abnormal_blood_circulation0.80125726
96MP0000858_altered_metastatic_potential0.79906120
97MP0001175_abnormal_lung_morphology0.78392158
98MP0010386_abnormal_urinary_bladder0.76855434
99MP0002177_abnormal_outer_ear0.75463427
100MP0003121_genomic_imprinting0.75140486
101MP0004233_abnormal_muscle_weight0.74487052
102MP0000462_abnormal_digestive_system0.73841558
103MP0000350_abnormal_cell_proliferation0.73463427
104MP0005193_abnormal_anterior_eye0.73299884
105MP0002086_abnormal_extraembryonic_tissu0.73152051
106MP0008007_abnormal_cellular_replicative0.72993402
107MP0004084_abnormal_cardiac_muscle0.72650006
108MP0003984_embryonic_growth_retardation0.72369030
109MP0002088_abnormal_embryonic_growth/wei0.72274580
110MP0003191_abnormal_cellular_cholesterol0.72078615
111MP0002998_abnormal_bone_remodeling0.71440518
112MP0003828_pulmonary_edema0.69988795
113MP0000579_abnormal_nail_morphology0.69736414
114MP0001697_abnormal_embryo_size0.69700198
115MP0001672_abnormal_embryogenesis/_devel0.68693931
116MP0005380_embryogenesis_phenotype0.68693931
117MP0003448_altered_tumor_morphology0.68369637
118MP0001849_ear_inflammation0.67962463
119MP0004510_myositis0.66257581
120MP0000759_abnormal_skeletal_muscle0.65535166
121MP0005058_abnormal_lysosome_morphology0.65135352
122MP0002092_abnormal_eye_morphology0.62539695
123MP0003453_abnormal_keratinocyte_physiol0.59511380
124MP0002133_abnormal_respiratory_system0.58151329
125MP0005388_respiratory_system_phenotype0.58151329
126MP0005165_increased_susceptibility_to0.56135416
127MP0000538_abnormal_urinary_bladder0.55607904

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.34224036
2Premature rupture of membranes (HP:0001788)7.00359507
3Shallow orbits (HP:0000586)4.46370104
4Arterial tortuosity (HP:0005116)4.19508910
5Ankle contracture (HP:0006466)4.04261313
6Atrophic scars (HP:0001075)3.93065504
7Aortic dissection (HP:0002647)3.87511292
8Cerebral aneurysm (HP:0004944)3.82085432
9Peritonitis (HP:0002586)3.81012920
10Cervical subluxation (HP:0003308)3.78885806
11Neonatal short-limb short stature (HP:0008921)3.77072575
12Abnormality of dentin (HP:0010299)3.74537878
13Soft skin (HP:0000977)3.73026416
14Genu recurvatum (HP:0002816)3.58284865
15Bladder diverticulum (HP:0000015)3.52559213
16Wormian bones (HP:0002645)3.23183336
17Fragile skin (HP:0001030)3.20651116
18Dilatation of the ascending aorta (HP:0005111)3.19418492
19Blue sclerae (HP:0000592)3.02222050
20Biconcave vertebral bodies (HP:0004586)3.01464370
21Aortic aneurysm (HP:0004942)2.98520850
22Mitral valve prolapse (HP:0001634)2.92448338
23Broad metatarsal (HP:0001783)2.89058146
24Vertebral compression fractures (HP:0002953)2.80985085
25Spinal rigidity (HP:0003306)2.78363464
26Wrist flexion contracture (HP:0001239)2.75365430
27Follicular hyperkeratosis (HP:0007502)2.68307808
28Bowel diverticulosis (HP:0005222)2.66219763
29Mild short stature (HP:0003502)2.64551486
30Type 1 muscle fiber predominance (HP:0003803)2.62908805
31Mesomelia (HP:0003027)2.58542434
32Epiphyseal dysplasia (HP:0002656)2.56492187
33Abnormality of the acetabulum (HP:0003170)2.49997748
34Disproportionate tall stature (HP:0001519)2.46326376
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.44068462
36Short 4th metacarpal (HP:0010044)2.44068462
37Hypoventilation (HP:0002791)2.36029587
38Aortic regurgitation (HP:0001659)2.34248212
39Increased connective tissue (HP:0009025)2.34245687
40Deviation of the hallux (HP:0010051)2.34159074
41Coronal craniosynostosis (HP:0004440)2.32652661
42Hyperextensible skin (HP:0000974)2.30579737
43Hypoplastic ischia (HP:0003175)2.29555370
44Elbow flexion contracture (HP:0002987)2.28790215
45Ulnar bowing (HP:0003031)2.28056136
46Coxa vara (HP:0002812)2.26047341
47Hallux valgus (HP:0001822)2.25966768
48Cardiovascular calcification (HP:0011915)2.21595512
49Mitral stenosis (HP:0001718)2.21192397
50Overgrowth (HP:0001548)2.20758090
51Platyspondyly (HP:0000926)2.20485604
52Osteoarthritis (HP:0002758)2.18981302
53Cupped ribs (HP:0000887)2.18692008
54Broad long bones (HP:0005622)2.17592523
55Wide anterior fontanel (HP:0000260)2.17385565
56Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.15524815
57Joint laxity (HP:0001388)2.15377854
58Radial bowing (HP:0002986)2.15227763
59Breech presentation (HP:0001623)2.14610315
60Spinal cord compression (HP:0002176)2.14241152
61Abnormal delivery (HP:0001787)2.12340940
62Tibial bowing (HP:0002982)2.09565161
63Spinal cord lesions (HP:0100561)2.08808557
64Syringomyelia (HP:0003396)2.08808557
65Natal tooth (HP:0000695)2.07629691
66Mildly elevated creatine phosphokinase (HP:0008180)2.07226355
67Abnormality of the calcaneus (HP:0008364)2.06399790
68Abnormality of the peritoneum (HP:0002585)2.06298505
69Asymmetry of the thorax (HP:0001555)2.06042457
70Slender build (HP:0001533)2.05952798
71Broad ribs (HP:0000885)2.04233847
72Achilles tendon contracture (HP:0001771)2.00349706
73Abnormality of carpal bone ossification (HP:0006257)1.99383498
74Decreased skull ossification (HP:0004331)1.98563243
75Abnormality of the ischium (HP:0003174)1.97865944
76Aneurysm (HP:0002617)1.97253295
77Mitral regurgitation (HP:0001653)1.96407523
78Abnormal ossification of hand bones (HP:0005921)1.96326707
79Congenital glaucoma (HP:0001087)1.96089119
80Joint stiffness (HP:0001387)1.95963323
81Vascular tortuosity (HP:0004948)1.95909410
82Abnormality of skeletal muscle fiber size (HP:0012084)1.95345642
83Abnormal vertebral ossification (HP:0100569)1.95264836
84Increased density of long bones (HP:0006392)1.94850873
85Bell-shaped thorax (HP:0001591)1.93435734
86Protruding ear (HP:0000411)1.92555355
87Metaphyseal cupping (HP:0003021)1.91383472
88Thin bony cortex (HP:0002753)1.91364920
89Inguinal hernia (HP:0000023)1.91186448
90Ovoid vertebral bodies (HP:0003300)1.91160871
91Abnormality of the 4th metacarpal (HP:0010012)1.90188319
92Hip contracture (HP:0003273)1.89859916
93Osteolytic defects of the phalanges of the hand (HP:0009771)1.89726724
94Osteolytic defects of the hand bones (HP:0009699)1.89726724
95Buphthalmos (HP:0000557)1.88988183
96Aortic valve stenosis (HP:0001650)1.88208704
97Camptodactyly of toe (HP:0001836)1.87897503
98Knee flexion contracture (HP:0006380)1.87082631
99Long toe (HP:0010511)1.86314777
100Absent frontal sinuses (HP:0002688)1.86283332
101Ectopia lentis (HP:0001083)1.85581737
102Exostoses (HP:0100777)1.84842493
103Generalized amyotrophy (HP:0003700)1.84356365
104Short nail (HP:0001799)1.83782992
105Broad phalanx (HP:0006009)1.82128746
106Femoral bowing (HP:0002980)1.81979878
107Spondylolisthesis (HP:0003302)1.81240567
108Abnormality of skull ossification (HP:0002703)1.81167668
109Abnormality of the Achilles tendon (HP:0005109)1.80947842
110Abnormality of the 2nd finger (HP:0004100)1.79607176
111Bowed forearm bones (HP:0003956)1.79489890
112Bowing of the arm (HP:0006488)1.79489890
113Delayed cranial suture closure (HP:0000270)1.78625012
114Increased variability in muscle fiber diameter (HP:0003557)1.77655290
115Nonimmune hydrops fetalis (HP:0001790)1.77105804
116Renal duplication (HP:0000075)1.76797103
117Morphological abnormality of the middle ear (HP:0008609)1.76332992
118Slender long bone (HP:0003100)1.74690442
119Broad thumb (HP:0011304)1.73888004
120Thoracolumbar scoliosis (HP:0002944)1.73259053
121Osteopenia (HP:0000938)1.72541679
122Hyperacusis (HP:0010780)1.72434548
123Round ear (HP:0100830)1.72275713
124Upper limb amyotrophy (HP:0009129)1.71726610
125Distal upper limb amyotrophy (HP:0007149)1.71726610
126Premature skin wrinkling (HP:0100678)1.69349182
127Arachnodactyly (HP:0001166)1.67651911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.70016354
2TRIB34.12166666
3TTN3.62138895
4PKN23.49335461
5PDGFRA3.01375291
6LATS22.96760944
7LATS12.92382421
8NTRK12.79360668
9ERN12.30858437
10EPHB22.03791854
11TESK11.98664486
12PAK41.89889117
13PAK21.88328259
14RIPK11.87190339
15PRKD21.84067229
16LRRK21.77302866
17TRPM71.71565628
18PTK21.68249707
19PTK61.65469072
20EEF2K1.61031479
21DMPK1.59076623
22MAP3K101.57058628
23STK31.54346298
24EPHA21.53633552
25RPS6KA41.51701747
26IRAK31.50039586
27BMX1.46430220
28SMG11.41289128
29FER1.39935543
30STK381.36133108
31CDK121.34373221
32ERBB31.31626399
33LIMK11.29839265
34ERBB41.27826209
35ILK1.27751406
36FGFR11.21121746
37FGFR41.18899405
38TGFBR11.18385642
39SIK11.15261402
40NEK21.12166193
41FLT31.11452471
42STK38L1.10819267
43STK101.10283782
44PIM21.09142450
45MTOR1.08966798
46PTK2B1.07196708
47AKT31.05270717
48SCYL21.05169979
49PAK31.03559777
50PIK3CG1.01671607
51CDC71.00181395
52MST1R0.97070935
53TAOK20.94602606
54MAP3K80.93835374
55TESK20.90318788
56ARAF0.89997789
57PDGFRB0.89405336
58ROCK10.88980898
59NME20.88580677
60MAP3K30.88181354
61MKNK10.86431267
62EPHA30.85983441
63PRKG20.85800325
64MAP2K30.84929854
65ABL20.84616422
66GRK70.83449888
67CDK70.82889416
68LMTK20.81395781
69MET0.79636584
70MOS0.79471484
71TGFBR20.77135681
72MAP3K60.76730335
73TIE10.73651405
74CDK60.72403858
75NEK90.71633650
76PAK10.71250188
77PLK20.70282861
78RPS6KB20.68996810
79PRPF4B0.66605212
80ALK0.64714503
81CAMK1G0.64702987
82GSK3A0.63787000
83WNK10.61599609
84PNCK0.61314224
85ROCK20.60214014
86CDK80.60186386
87MELK0.58331234
88STK240.57792941
89PAK60.55977093
90ICK0.55705875
91WEE10.53971129
92MYLK0.52477830
93KSR20.52193216
94NEK10.52150135
95MAP3K120.51950002
96PLK30.51381162
97BRSK20.50041757
98EPHB10.47482147
99MAP2K10.46471884
100AURKB0.45760717
101KDR0.44807534
102DYRK1B0.44290826
103INSR0.43431093
104ADRBK10.41264723
105DAPK30.40514647
106PLK10.39346195
107CLK10.39266247
108KSR10.39001408
109PRKD30.38300386
110PASK0.37986852
111PIK3CA0.36033159
112RPS6KC10.35744886
113RPS6KL10.35744886
114CDK40.35552641
115TYRO30.35194489
116TTK0.34977814
117MAPK70.34461955
118RET0.33552249
119CDK140.32489407
120PRKD10.32306584
121MAPKAPK20.32145599
122SRC0.31577285
123BRAF0.31367301
124CDK150.31151843
125CDC42BPA0.31106261
126MAPK10.30914302
127MAPKAPK30.30034486
128CDK11A0.29607047
129TAOK10.28598863
130RPS6KA20.28598171
131AKT10.27789679
132PDPK10.27508667
133FRK0.27274673
134RPS6KA60.27027244

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.75719248
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.77890674
3Focal adhesion_Homo sapiens_hsa045102.76908725
4Proteoglycans in cancer_Homo sapiens_hsa052052.17380763
5Adherens junction_Homo sapiens_hsa045202.11005235
6Bladder cancer_Homo sapiens_hsa052192.08099031
7Protein digestion and absorption_Homo sapiens_hsa049742.07477958
8Small cell lung cancer_Homo sapiens_hsa052222.05935968
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.00006176
10Hippo signaling pathway_Homo sapiens_hsa043901.97956375
11TGF-beta signaling pathway_Homo sapiens_hsa043501.91864158
12Amoebiasis_Homo sapiens_hsa051461.89641565
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.87599991
14Basal cell carcinoma_Homo sapiens_hsa052171.86920771
15MicroRNAs in cancer_Homo sapiens_hsa052061.84081689
16Chronic myeloid leukemia_Homo sapiens_hsa052201.57948748
17p53 signaling pathway_Homo sapiens_hsa041151.57219539
18Hedgehog signaling pathway_Homo sapiens_hsa043401.57172577
19* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.52409035
20PI3K-Akt signaling pathway_Homo sapiens_hsa041511.51971278
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.51782150
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.51512141
23Other glycan degradation_Homo sapiens_hsa005111.51429323
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.42917638
25Dilated cardiomyopathy_Homo sapiens_hsa054141.42490992
26Cell cycle_Homo sapiens_hsa041101.40655098
27Prion diseases_Homo sapiens_hsa050201.37598799
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36111850
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.34810873
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31326450
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.30103133
32Viral myocarditis_Homo sapiens_hsa054161.29975129
33Malaria_Homo sapiens_hsa051441.27952787
34Melanoma_Homo sapiens_hsa052181.27012368
35Shigellosis_Homo sapiens_hsa051311.24238551
36Pathways in cancer_Homo sapiens_hsa052001.23001913
37Wnt signaling pathway_Homo sapiens_hsa043101.16368534
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15546114
39HTLV-I infection_Homo sapiens_hsa051661.15012914
40Prostate cancer_Homo sapiens_hsa052151.13828947
41Galactose metabolism_Homo sapiens_hsa000521.11564683
42N-Glycan biosynthesis_Homo sapiens_hsa005101.11194459
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10616799
44Complement and coagulation cascades_Homo sapiens_hsa046101.10498874
45Vibrio cholerae infection_Homo sapiens_hsa051101.09500254
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07829729
47Pancreatic cancer_Homo sapiens_hsa052121.06640211
48Tight junction_Homo sapiens_hsa045301.06231323
49Colorectal cancer_Homo sapiens_hsa052101.05908941
50RNA transport_Homo sapiens_hsa030131.05140695
51Glioma_Homo sapiens_hsa052141.04598119
52Central carbon metabolism in cancer_Homo sapiens_hsa052301.02230999
53Viral carcinogenesis_Homo sapiens_hsa052031.00115919
54Rap1 signaling pathway_Homo sapiens_hsa040150.97564804
55Toxoplasmosis_Homo sapiens_hsa051450.96092406
56Platelet activation_Homo sapiens_hsa046110.94600790
57Thyroid cancer_Homo sapiens_hsa052160.90162189
58HIF-1 signaling pathway_Homo sapiens_hsa040660.89656756
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.89449483
60Endometrial cancer_Homo sapiens_hsa052130.89306779
61Notch signaling pathway_Homo sapiens_hsa043300.86098947
62Hepatitis B_Homo sapiens_hsa051610.84934164
63Axon guidance_Homo sapiens_hsa043600.84120803
64Melanogenesis_Homo sapiens_hsa049160.81811436
65VEGF signaling pathway_Homo sapiens_hsa043700.80606342
66Renal cell carcinoma_Homo sapiens_hsa052110.79066273
67Lysosome_Homo sapiens_hsa041420.78864027
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78221735
69Estrogen signaling pathway_Homo sapiens_hsa049150.76845961
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76329554
71Apoptosis_Homo sapiens_hsa042100.76171214
72TNF signaling pathway_Homo sapiens_hsa046680.74115458
73mTOR signaling pathway_Homo sapiens_hsa041500.73822100
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73262696
75Leishmaniasis_Homo sapiens_hsa051400.73130061
76Phagosome_Homo sapiens_hsa041450.73108068
77Spliceosome_Homo sapiens_hsa030400.73038720
78One carbon pool by folate_Homo sapiens_hsa006700.71081266
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.69862441
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68125137
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67753455
82Ribosome_Homo sapiens_hsa030100.67316844
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.66998287
84Salmonella infection_Homo sapiens_hsa051320.66224059
85DNA replication_Homo sapiens_hsa030300.66135662
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65698815
87Gap junction_Homo sapiens_hsa045400.64628066
88Non-small cell lung cancer_Homo sapiens_hsa052230.64554545
89Sulfur metabolism_Homo sapiens_hsa009200.64372528
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63386328
91mRNA surveillance pathway_Homo sapiens_hsa030150.61125113
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57899546
93Sphingolipid metabolism_Homo sapiens_hsa006000.57812424
94Acute myeloid leukemia_Homo sapiens_hsa052210.57759155
95Pertussis_Homo sapiens_hsa051330.56531193
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56079507
97GnRH signaling pathway_Homo sapiens_hsa049120.52525692
98Endocytosis_Homo sapiens_hsa041440.50390346
99FoxO signaling pathway_Homo sapiens_hsa040680.50009529
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48554806
101Pentose phosphate pathway_Homo sapiens_hsa000300.48211458
102Epstein-Barr virus infection_Homo sapiens_hsa051690.47264028
103Legionellosis_Homo sapiens_hsa051340.46934692
104Thyroid hormone synthesis_Homo sapiens_hsa049180.46502329
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45728328
106Osteoclast differentiation_Homo sapiens_hsa043800.44405405
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43817953
108Oocyte meiosis_Homo sapiens_hsa041140.43394788
109MAPK signaling pathway_Homo sapiens_hsa040100.43004486
110Ras signaling pathway_Homo sapiens_hsa040140.42662748
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.42508389
112Prolactin signaling pathway_Homo sapiens_hsa049170.42407745
113ErbB signaling pathway_Homo sapiens_hsa040120.42156753
114Hepatitis C_Homo sapiens_hsa051600.41170122
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40691736
116Renin-angiotensin system_Homo sapiens_hsa046140.39111374
117AMPK signaling pathway_Homo sapiens_hsa041520.39052267
118Insulin resistance_Homo sapiens_hsa049310.38832537
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38776180
120Cocaine addiction_Homo sapiens_hsa050300.36488781
121Insulin signaling pathway_Homo sapiens_hsa049100.36089064
122Fructose and mannose metabolism_Homo sapiens_hsa000510.30204692

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