CKAP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.79127454
2sister chromatid segregation (GO:0000819)4.45070868
3nuclear pore complex assembly (GO:0051292)4.32149317
4mitotic sister chromatid cohesion (GO:0007064)4.29251100
5mitotic chromosome condensation (GO:0007076)4.27302350
6regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.21868750
7nuclear pore organization (GO:0006999)4.17599775
8protein localization to kinetochore (GO:0034501)4.01932604
9mitotic sister chromatid segregation (GO:0000070)3.94831073
10pre-miRNA processing (GO:0031054)3.82456168
11regulation of centriole replication (GO:0046599)3.74658815
12DNA strand elongation involved in DNA replication (GO:0006271)3.68314083
13DNA strand elongation (GO:0022616)3.58166848
14positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.55451071
15positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.55451071
16positive regulation of mitotic sister chromatid separation (GO:1901970)3.55451071
17DNA unwinding involved in DNA replication (GO:0006268)3.54962174
18DNA ligation (GO:0006266)3.49752735
19kinetochore organization (GO:0051383)3.49309458
20establishment of integrated proviral latency (GO:0075713)3.42341142
21regulation of sister chromatid cohesion (GO:0007063)3.38335403
22protein localization to chromosome, centromeric region (GO:0071459)3.36683943
23double-strand break repair via nonhomologous end joining (GO:0006303)3.34494225
24non-recombinational repair (GO:0000726)3.34494225
25regulation of translational fidelity (GO:0006450)3.34427164
26DNA replication initiation (GO:0006270)3.32241589
27layer formation in cerebral cortex (GO:0021819)3.31525015
28establishment of nucleus localization (GO:0040023)3.20175336
29positive regulation of chromosome segregation (GO:0051984)3.18199333
30telomere maintenance via semi-conservative replication (GO:0032201)3.17916368
31negative regulation of histone methylation (GO:0031061)3.17219612
32regulation of spindle organization (GO:0090224)3.16613659
33regulation of mitotic spindle organization (GO:0060236)3.15568413
34CENP-A containing nucleosome assembly (GO:0034080)3.15462267
35regulation of RNA export from nucleus (GO:0046831)3.15425790
36pore complex assembly (GO:0046931)3.14132522
37attachment of spindle microtubules to kinetochore (GO:0008608)3.12707617
38nuclear envelope organization (GO:0006998)3.10017732
39peptidyl-lysine dimethylation (GO:0018027)3.08774601
40regulation of DNA endoreduplication (GO:0032875)3.05675245
41regulation of chromosome segregation (GO:0051983)3.04165009
42DNA synthesis involved in DNA repair (GO:0000731)3.03673745
43paraxial mesoderm development (GO:0048339)3.03350424
44regulation of histone H3-K9 methylation (GO:0051570)3.02375496
45mitotic recombination (GO:0006312)3.02310012
46protein complex localization (GO:0031503)3.00598307
47DNA topological change (GO:0006265)3.00536855
48spindle checkpoint (GO:0031577)3.00006384
49DNA replication checkpoint (GO:0000076)2.98923724
50mitotic cytokinesis (GO:0000281)2.96954825
51establishment of mitotic spindle localization (GO:0040001)2.94511493
52spindle assembly checkpoint (GO:0071173)2.94471594
53glucocorticoid receptor signaling pathway (GO:0042921)2.93772509
54metaphase plate congression (GO:0051310)2.92582015
55cytoskeleton-dependent cytokinesis (GO:0061640)2.91965067
56mitotic metaphase plate congression (GO:0007080)2.89710734
57regulation of centrosome cycle (GO:0046605)2.88239807
58regulation of mitotic metaphase/anaphase transition (GO:0030071)2.87957217
59microtubule depolymerization (GO:0007019)2.86484706
60regulation of mitotic sister chromatid separation (GO:0010965)2.86052879
61regulation of mitotic sister chromatid segregation (GO:0033047)2.86052879
62regulation of sister chromatid segregation (GO:0033045)2.86052879
63protein localization to chromosome (GO:0034502)2.86033913
64regulation of centrosome duplication (GO:0010824)2.85895331
65protein-DNA complex disassembly (GO:0032986)2.85199631
66nucleosome disassembly (GO:0006337)2.85199631
67chromosome condensation (GO:0030261)2.83721480
68regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.81473608
69mitotic spindle assembly checkpoint (GO:0007094)2.80947115
70negative regulation of chromosome segregation (GO:0051985)2.80442893
71mitotic spindle checkpoint (GO:0071174)2.80210911
72membrane disassembly (GO:0030397)2.80106482
73nuclear envelope disassembly (GO:0051081)2.80106482
74mitotic nuclear envelope disassembly (GO:0007077)2.79875229
75establishment of chromosome localization (GO:0051303)2.79611460
76DNA replication-dependent nucleosome organization (GO:0034723)2.78573244
77DNA replication-dependent nucleosome assembly (GO:0006335)2.78573244
78negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.77789728
79negative regulation of sister chromatid segregation (GO:0033046)2.77789728
80negative regulation of mitotic sister chromatid separation (GO:2000816)2.77789728
81negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77789728
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76739774
83establishment of spindle localization (GO:0051293)2.75483969
84telomere maintenance via recombination (GO:0000722)2.74571086
85* spindle organization (GO:0007051)2.69805040
86negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.69698219
87regulation of nucleobase-containing compound transport (GO:0032239)2.69176730
88DNA geometric change (GO:0032392)2.68624849
89DNA duplex unwinding (GO:0032508)2.68616282
90spindle assembly involved in mitosis (GO:0090307)2.68132275
91nucleus localization (GO:0051647)2.67998693
92chromosome segregation (GO:0007059)2.67018551
93* mitotic cell cycle (GO:0000278)2.65519978
94negative regulation of organelle assembly (GO:1902116)2.65334480
95meiotic chromosome segregation (GO:0045132)2.64625194
96microtubule polymerization or depolymerization (GO:0031109)2.64346250
97chromosome organization (GO:0051276)2.64240359
98mitotic spindle organization (GO:0007052)2.64132749
99cellular protein complex localization (GO:0034629)2.62417818
100chromatin assembly (GO:0031497)2.62407791
101kinetochore assembly (GO:0051382)2.60991717
102establishment of mitotic spindle orientation (GO:0000132)2.59570490
103regulation of short-term neuronal synaptic plasticity (GO:0048172)2.58082470
104negative regulation of DNA repair (GO:0045738)2.56251733
105synaptic vesicle maturation (GO:0016188)2.54975776
106regulation of telomere maintenance via telomerase (GO:0032210)2.54846075
107NLS-bearing protein import into nucleus (GO:0006607)2.54221710
108DNA packaging (GO:0006323)2.51703039
109microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.50439072
110chromatin assembly or disassembly (GO:0006333)2.47997141
111interkinetic nuclear migration (GO:0022027)2.46388071
112histone exchange (GO:0043486)2.42210677
113histone H2A monoubiquitination (GO:0035518)2.40168772
114cytoplasmic mRNA processing body assembly (GO:0033962)2.39465680
115sister chromatid cohesion (GO:0007062)2.37450445
116dosage compensation (GO:0007549)2.36431064
117DNA conformation change (GO:0071103)2.35620707
118DNA replication-independent nucleosome organization (GO:0034724)2.34482581
119DNA replication-independent nucleosome assembly (GO:0006336)2.34482581
120chromatin remodeling at centromere (GO:0031055)2.33554271
121heterochromatin organization (GO:0070828)2.33126433
122positive regulation of dendritic spine morphogenesis (GO:0061003)2.32607688
123positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.31953077
124corticosteroid receptor signaling pathway (GO:0031958)2.31183146
125ATP-dependent chromatin remodeling (GO:0043044)2.30800526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.40989980
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.74501739
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.83529537
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.63952167
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.30060374
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.12566555
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.04550196
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.93265327
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.86000292
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.85226011
11* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53996905
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.47530621
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37707957
14EZH2_22144423_ChIP-Seq_EOC_Human2.21413790
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16234844
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08905438
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07830257
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06522185
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.03078831
20AR_21909140_ChIP-Seq_LNCAP_Human1.94608191
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91071535
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90787718
23SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.81392874
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.79315736
25TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.78294512
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76238517
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70349520
28ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67458430
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65441050
30FUS_26573619_Chip-Seq_HEK293_Human1.64592778
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59176887
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58772696
33XRN2_22483619_ChIP-Seq_HELA_Human1.57673500
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51409412
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47273471
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46563655
37SOX2_16153702_ChIP-ChIP_HESCs_Human1.41837220
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41616447
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41199263
40EWS_26573619_Chip-Seq_HEK293_Human1.39473646
41PKCTHETA_26484144_Chip-Seq_BREAST_Human1.38078087
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35890988
43TTF2_22483619_ChIP-Seq_HELA_Human1.35637300
44DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35063216
45* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.34924210
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33443059
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33323932
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31762479
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31563239
50SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.30664131
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30594113
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.29672955
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28349955
54ELK1_19687146_ChIP-ChIP_HELA_Human1.27173407
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27065421
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26561716
57RARB_27405468_Chip-Seq_BRAIN_Mouse1.26481560
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26002649
59ZNF274_21170338_ChIP-Seq_K562_Hela1.24296972
60GBX2_23144817_ChIP-Seq_PC3_Human1.24286578
61POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.23412694
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22618481
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21901501
64DCP1A_22483619_ChIP-Seq_HELA_Human1.21766972
65* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21150786
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19989864
67CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17605913
68CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17558156
69SOX9_26525672_Chip-Seq_HEART_Mouse1.16549486
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15168778
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13989589
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12896933
73SOX17_20123909_ChIP-Seq_XEN_Mouse1.12451938
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12275584
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11453996
76* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10433530
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09789802
78KDM5A_27292631_Chip-Seq_BREAST_Human1.09558172
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09249891
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07216847
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.06785817
82NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06157429
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03588421
84TP53_16413492_ChIP-PET_HCT116_Human1.03139318
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01785933
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01737839
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01724667
88STAT3_23295773_ChIP-Seq_U87_Human1.01724213
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01605119
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.00621601
91TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99151366
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99112281
93* CHD1_26751641_Chip-Seq_LNCaP_Human0.98677261
94TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98459976
95SMAD_19615063_ChIP-ChIP_OVARY_Human0.98276201
96WT1_19549856_ChIP-ChIP_CCG9911_Human0.97066045
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96077007
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95907917
99ISL1_27105846_Chip-Seq_CPCs_Mouse0.95777719
100* SMAD4_21799915_ChIP-Seq_A2780_Human0.94861554
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94516067
102TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92220917
103CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91753264
104CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91446274
105TCF4_18268006_ChIP-ChIP_LS174T_Human0.91134432
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91078344
107MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90775986
108ETS1_20019798_ChIP-Seq_JURKAT_Human0.90443655
109REST_21632747_ChIP-Seq_MESCs_Mouse0.89703471
110AR_19668381_ChIP-Seq_PC3_Human0.89498640
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89229847
112SOX2_21211035_ChIP-Seq_LN229_Gbm0.88534570
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88422778
114CLOCK_20551151_ChIP-Seq_293T_Human0.88090156
115NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87895212
116* TCF4_23295773_ChIP-Seq_U87_Human0.85367731
117* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85258166
118AR_21572438_ChIP-Seq_LNCaP_Human0.84755173
119TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.83577296
120NANOG_16153702_ChIP-ChIP_HESCs_Human0.81842207
121GABP_19822575_ChIP-Seq_HepG2_Human0.81211792
122NELFA_20434984_ChIP-Seq_ESCs_Mouse0.80230793
123PADI4_21655091_ChIP-ChIP_MCF-7_Human0.79299067
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79250279
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79250279
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79123010
127RNF2_27304074_Chip-Seq_NSC_Mouse0.78920974
128DROSHA_22980978_ChIP-Seq_HELA_Human0.77912990
129CIITA_25753668_ChIP-Seq_RAJI_Human0.77840562
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77392530
131GATA1_26923725_Chip-Seq_HPCs_Mouse0.76957504
132MYC_22102868_ChIP-Seq_BL_Human0.76895948
133RNF2_27304074_Chip-Seq_ESCs_Mouse0.76438719
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.76108193
135RING1B_27294783_Chip-Seq_NPCs_Mouse0.75763294
136NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.75651788
137SMAD3_21741376_ChIP-Seq_EPCs_Human0.74992741
138* SMAD3_21741376_ChIP-Seq_ESCs_Human0.74986373
139ZNF263_19887448_ChIP-Seq_K562_Human0.74614486
140CTBP1_25329375_ChIP-Seq_LNCAP_Human0.73885295
141HOXB4_20404135_ChIP-ChIP_EML_Mouse0.73025260
142SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.72963205
143PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72638817
144JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.72311374
145CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.70264736
146ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.69157239
147TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.67795644
148* FOXP3_21729870_ChIP-Seq_TREG_Human0.67067910
149GATA4_21415370_ChIP-Seq_HL-1_Mouse0.65816302
150SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.65781251

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation2.74194210
2MP0004859_abnormal_synaptic_plasticity2.59580903
3MP0010094_abnormal_chromosome_stability2.52299487
4MP0003121_genomic_imprinting2.40352682
5MP0003111_abnormal_nucleus_morphology2.39170632
6MP0003123_paternal_imprinting2.37470995
7MP0008877_abnormal_DNA_methylation2.33134039
8MP0003787_abnormal_imprinting2.21770919
9MP0003077_abnormal_cell_cycle1.91992878
10MP0008057_abnormal_DNA_replication1.82628512
11MP0009697_abnormal_copulation1.80646997
12MP0000537_abnormal_urethra_morphology1.78539492
13MP0003890_abnormal_embryonic-extraembry1.75128679
14MP0010030_abnormal_orbit_morphology1.74109426
15MP0005623_abnormal_meninges_morphology1.71412333
16MP0010307_abnormal_tumor_latency1.70394903
17MP0003122_maternal_imprinting1.69716230
18MP0005076_abnormal_cell_differentiation1.66608814
19MP0002877_abnormal_melanocyte_morpholog1.64731647
20MP0000778_abnormal_nervous_system1.60929342
21MP0003941_abnormal_skin_development1.59469234
22MP0004957_abnormal_blastocyst_morpholog1.52215009
23MP0002084_abnormal_developmental_patter1.50907812
24MP0003635_abnormal_synaptic_transmissio1.50872625
25MP0005187_abnormal_penis_morphology1.50383024
26MP0003937_abnormal_limbs/digits/tail_de1.48995677
27MP0001730_embryonic_growth_arrest1.47131693
28MP0003718_maternal_effect1.46128552
29MP0004270_analgesia1.45349161
30MP0003861_abnormal_nervous_system1.44648033
31MP0001299_abnormal_eye_distance/1.42237082
32MP0010352_gastrointestinal_tract_polyps1.40521030
33MP0002009_preneoplasia1.39411574
34MP0003693_abnormal_embryo_hatching1.36353774
35MP0000428_abnormal_craniofacial_morphol1.35149165
36MP0004197_abnormal_fetal_growth/weight/1.35045789
37MP0004233_abnormal_muscle_weight1.34492566
38MP0002085_abnormal_embryonic_tissue1.34152371
39MP0000566_synostosis1.34005445
40MP0005423_abnormal_somatic_nervous1.31434935
41MP0002653_abnormal_ependyma_morphology1.31167977
42MP0000350_abnormal_cell_proliferation1.31037600
43MP0009046_muscle_twitch1.31002649
44MP0008932_abnormal_embryonic_tissue1.29468308
45MP0009780_abnormal_chondrocyte_physiolo1.27625990
46MP0001293_anophthalmia1.26211532
47MP0001346_abnormal_lacrimal_gland1.24979709
48MP0004811_abnormal_neuron_physiology1.22943191
49MP0002063_abnormal_learning/memory/cond1.22052610
50MP0001286_abnormal_eye_development1.21459677
51MP0005171_absent_coat_pigmentation1.20133877
52MP0003119_abnormal_digestive_system1.19068647
53MP0005380_embryogenesis_phenotype1.18404915
54MP0001672_abnormal_embryogenesis/_devel1.18404915
55MP0002152_abnormal_brain_morphology1.17157124
56MP0001697_abnormal_embryo_size1.16814295
57MP0006292_abnormal_olfactory_placode1.16516325
58MP0003880_abnormal_central_pattern1.15786407
59MP0009703_decreased_birth_body1.15381363
60MP0003385_abnormal_body_wall1.15130362
61MP0010234_abnormal_vibrissa_follicle1.14001371
62MP0002092_abnormal_eye_morphology1.13387914
63MP0003705_abnormal_hypodermis_morpholog1.13311005
64MP0000631_abnormal_neuroendocrine_gland1.12992994
65MP0008007_abnormal_cellular_replicative1.12178295
66MP0003935_abnormal_craniofacial_develop1.11615973
67MP0002184_abnormal_innervation1.11480064
68MP0000955_abnormal_spinal_cord1.10516257
69MP0006072_abnormal_retinal_apoptosis1.09524581
70MP0008058_abnormal_DNA_repair1.08581663
71MP0003115_abnormal_respiratory_system1.05575797
72MP0003755_abnormal_palate_morphology1.04807871
73MP0003984_embryonic_growth_retardation1.04779991
74MP0004858_abnormal_nervous_system1.04221483
75MP0003283_abnormal_digestive_organ1.04171835
76MP0002734_abnormal_mechanical_nocicepti1.02692262
77MP0002088_abnormal_embryonic_growth/wei1.02561498
78MP0000579_abnormal_nail_morphology1.01327646
79MP0001968_abnormal_touch/_nociception1.01136057
80MP0002234_abnormal_pharynx_morphology0.98912767
81MP0004185_abnormal_adipocyte_glucose0.98099047
82MP0000733_abnormal_muscle_development0.97392279
83MP0002086_abnormal_extraembryonic_tissu0.97129556
84MP0009053_abnormal_anal_canal0.96202014
85MP0003942_abnormal_urinary_system0.95854620
86MP0002111_abnormal_tail_morphology0.95525050
87MP0000534_abnormal_ureter_morphology0.95511056
88MP0004272_abnormal_basement_membrane0.94224565
89MP0003567_abnormal_fetal_cardiomyocyte0.94143517
90MP0004885_abnormal_endolymph0.94082997
91MP0002882_abnormal_neuron_morphology0.93481496
92MP0001929_abnormal_gametogenesis0.93169019
93MP0002080_prenatal_lethality0.92813228
94MP0005499_abnormal_olfactory_system0.92694386
95MP0005394_taste/olfaction_phenotype0.92694386
96MP0000313_abnormal_cell_death0.91301990
97MP0002064_seizures0.90857512
98MP0009745_abnormal_behavioral_response0.90839027
99MP0002081_perinatal_lethality0.90817086
100MP0003315_abnormal_perineum_morphology0.90782192
101MP0009672_abnormal_birth_weight0.89053131
102MP0000432_abnormal_head_morphology0.88936551
103MP0002751_abnormal_autonomic_nervous0.88492031
104MP0005248_abnormal_Harderian_gland0.87202252
105MP0002210_abnormal_sex_determination0.86896728
106MP0008789_abnormal_olfactory_epithelium0.86821825
107MP0002396_abnormal_hematopoietic_system0.86176186
108MP0002116_abnormal_craniofacial_bone0.85628849
109MP0005409_darkened_coat_color0.85060712
110MP0000049_abnormal_middle_ear0.84980713
111MP0005257_abnormal_intraocular_pressure0.84669725
112MP0002572_abnormal_emotion/affect_behav0.82287877
113MP0000762_abnormal_tongue_morphology0.81702845
114MP0002233_abnormal_nose_morphology0.81646072
115MP0003632_abnormal_nervous_system0.81596053
116MP0003566_abnormal_cell_adhesion0.81429464
117MP0002557_abnormal_social/conspecific_i0.81272815
118MP0001486_abnormal_startle_reflex0.80927620
119MP0002067_abnormal_sensory_capabilities0.80389265
120MP0002697_abnormal_eye_size0.79906816
121MP0002938_white_spotting0.78500112
122MP0003698_abnormal_male_reproductive0.78115100
123MP0008569_lethality_at_weaning0.77916226
124MP0002114_abnormal_axial_skeleton0.76312292
125MP0000647_abnormal_sebaceous_gland0.74510857
126MP0001145_abnormal_male_reproductive0.73130668
127MP0001915_intracranial_hemorrhage0.71947241
128MP0003943_abnormal_hepatobiliary_system0.69284248
129MP0001177_atelectasis0.68817382
130MP0005384_cellular_phenotype0.68203682
131MP0005621_abnormal_cell_physiology0.67925957
132MP0001661_extended_life_span0.67867981
133MP0000653_abnormal_sex_gland0.66581413
134MP0003950_abnormal_plasma_membrane0.66511840
135MP0003699_abnormal_female_reproductive0.66262319
136MP0003786_premature_aging0.66027499
137MP0004264_abnormal_extraembryonic_tissu0.65978271

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)3.58216104
2Volvulus (HP:0002580)3.35176636
3Short 4th metacarpal (HP:0010044)3.18018190
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.18018190
5Increased nuchal translucency (HP:0010880)3.12720365
6Astrocytoma (HP:0009592)2.82610094
7Abnormality of the astrocytes (HP:0100707)2.82610094
8High anterior hairline (HP:0009890)2.66147091
9Hyperacusis (HP:0010780)2.45902474
10Meckel diverticulum (HP:0002245)2.44978796
11Renal duplication (HP:0000075)2.42396844
12Heterotopia (HP:0002282)2.42250349
13Aplasia/Hypoplasia of the uvula (HP:0010293)2.36740904
14Medulloblastoma (HP:0002885)2.34689332
15Papillary thyroid carcinoma (HP:0002895)2.34248900
16Abnormal lung lobation (HP:0002101)2.32560129
17Macroorchidism (HP:0000053)2.32246488
18Insidious onset (HP:0003587)2.30078227
19Termporal pattern (HP:0011008)2.30078227
20Renovascular hypertension (HP:0100817)2.29766816
21Glioma (HP:0009733)2.29421757
22Abnormality of the labia minora (HP:0012880)2.29242388
23Abnormality of the ileum (HP:0001549)2.28802754
24Pointed chin (HP:0000307)2.28078651
25Ependymoma (HP:0002888)2.26149799
26Abnormality of the 4th metacarpal (HP:0010012)2.25648744
27Overriding aorta (HP:0002623)2.25123428
28Overlapping toe (HP:0001845)2.23051948
29Abnormality of the preputium (HP:0100587)2.22053372
30Obsessive-compulsive behavior (HP:0000722)2.20758608
31Duodenal stenosis (HP:0100867)2.19195722
32Small intestinal stenosis (HP:0012848)2.19195722
33Colon cancer (HP:0003003)2.16598750
34Abnormality of the lower motor neuron (HP:0002366)2.12690887
35Aqueductal stenosis (HP:0002410)2.12457739
36Abnormality of chromosome segregation (HP:0002916)2.09722714
37Elfin facies (HP:0004428)2.09481448
38Insomnia (HP:0100785)2.08540720
39Bowel diverticulosis (HP:0005222)2.02383308
40Truncal obesity (HP:0001956)2.02230328
41Neoplasm of the oral cavity (HP:0100649)2.01047909
42Trigonocephaly (HP:0000243)2.00994981
43Aplasia/Hypoplasia of the sternum (HP:0006714)1.97023907
44Embryonal neoplasm (HP:0002898)1.96317068
45Absent radius (HP:0003974)1.93761587
46Deviation of the thumb (HP:0009603)1.92687853
47Ankyloglossia (HP:0010296)1.92519565
48Abnormality of the calcaneus (HP:0008364)1.92516783
49Proximal placement of thumb (HP:0009623)1.90946980
50Birth length less than 3rd percentile (HP:0003561)1.89652796
51Shallow orbits (HP:0000586)1.89243173
52Abnormality of the duodenum (HP:0002246)1.88642127
53Abnormality of the diencephalon (HP:0010662)1.87374993
54Vertebral arch anomaly (HP:0008438)1.86305740
55Subacute progressive viral hepatitis (HP:0006572)1.85781008
56Megalencephaly (HP:0001355)1.85026555
57Choanal atresia (HP:0000453)1.82704332
58Myelodysplasia (HP:0002863)1.82644623
59Flat cornea (HP:0007720)1.82304414
60Absent frontal sinuses (HP:0002688)1.81442017
61Action tremor (HP:0002345)1.81345631
62Sacral dimple (HP:0000960)1.81176444
63Aplasia involving forearm bones (HP:0009822)1.77978778
64Absent forearm bone (HP:0003953)1.77978778
65Asymmetry of the thorax (HP:0001555)1.76995245
66Facial hemangioma (HP:0000329)1.74511496
67Broad thumb (HP:0011304)1.73778716
68Shoulder girdle muscle weakness (HP:0003547)1.73701244
69Duplication of thumb phalanx (HP:0009942)1.72321297
70Chromsome breakage (HP:0040012)1.71972061
71Nephroblastoma (Wilms tumor) (HP:0002667)1.71317455
72Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70936396
73Amyotrophic lateral sclerosis (HP:0007354)1.70587405
74Impaired vibration sensation in the lower limbs (HP:0002166)1.69942169
75Impaired smooth pursuit (HP:0007772)1.69768819
76Long clavicles (HP:0000890)1.69636000
77Megalocornea (HP:0000485)1.69158336
78Progressive cerebellar ataxia (HP:0002073)1.67129587
7911 pairs of ribs (HP:0000878)1.65988212
80Transitional cell carcinoma of the bladder (HP:0006740)1.64910646
81Urinary bladder sphincter dysfunction (HP:0002839)1.64645426
82Microglossia (HP:0000171)1.63580033
83Deep philtrum (HP:0002002)1.63046760
84Embryonal renal neoplasm (HP:0011794)1.62773326
85Hypopigmentation of the fundus (HP:0007894)1.62388469
86Papilledema (HP:0001085)1.62150464
87Atresia of the external auditory canal (HP:0000413)1.61811806
88Large earlobe (HP:0009748)1.61785459
89Genetic anticipation (HP:0003743)1.61617593
90Abnormality of ocular smooth pursuit (HP:0000617)1.60999981
91Inappropriate behavior (HP:0000719)1.60983858
92Gastrointestinal carcinoma (HP:0002672)1.60276279
93Malignant gastrointestinal tract tumors (HP:0006749)1.60276279
94Urinary urgency (HP:0000012)1.59925313
95Abnormality of oral frenula (HP:0000190)1.59849726
96Neoplasm of the adrenal cortex (HP:0100641)1.59204392
97Limited elbow extension (HP:0001377)1.59199641
98Sloping forehead (HP:0000340)1.58308698
99Skull defect (HP:0001362)1.58230565
100Radioulnar synostosis (HP:0002974)1.58102267
101Focal seizures (HP:0007359)1.58016320
102Leiomyosarcoma (HP:0100243)1.57293340
103Uterine leiomyosarcoma (HP:0002891)1.57293340
104Broad phalanges of the hand (HP:0009768)1.57247958
105Broad distal phalanx of finger (HP:0009836)1.56960295
106Rhabdomyosarcoma (HP:0002859)1.55636657
107Arteriovenous malformation (HP:0100026)1.55270146
108Abnormality of the carotid arteries (HP:0005344)1.55161532
109Ectopic kidney (HP:0000086)1.54152607
110Neoplasm of striated muscle (HP:0009728)1.53720002
111Chromosomal breakage induced by crosslinking agents (HP:0003221)1.53571681
112Dysmetric saccades (HP:0000641)1.53084336
113Ulnar bowing (HP:0003031)1.52976930
114Sandal gap (HP:0001852)1.52842547
115Cafe-au-lait spot (HP:0000957)1.52588460
116Attention deficit hyperactivity disorder (HP:0007018)1.52402477
117Pelvic girdle muscle weakness (HP:0003749)1.51774957
118Truncal ataxia (HP:0002078)1.50760614
119Abnormality of cochlea (HP:0000375)1.50586461
120Buphthalmos (HP:0000557)1.49870165
121Hypospadias (HP:0000047)1.49432803
122Bladder neoplasm (HP:0009725)1.48955653
123Bladder carcinoma (HP:0002862)1.48955653
124Broad finger (HP:0001500)1.48917976
125Abnormality of the nasal septum (HP:0000419)1.48552543
126Relative macrocephaly (HP:0004482)1.47970696
127Omphalocele (HP:0001539)1.47672596
128Urethral obstruction (HP:0000796)1.47377146
129Narrow face (HP:0000275)1.47260062
130Selective tooth agenesis (HP:0001592)1.47109693
131Fibrous tissue neoplasm (HP:0012316)1.45602361
132Smooth philtrum (HP:0000319)1.45397929
133Abnormality of the distal phalanx of the thumb (HP:0009617)1.45086014
134Intellectual disability, profound (HP:0002187)1.45030489
135Arnold-Chiari malformation (HP:0002308)1.44983567
136Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.44893091
137Abnormality of chromosome stability (HP:0003220)1.44877614
138Enlarged penis (HP:0000040)1.44339237
139Abnormality of the phalanges of the hallux (HP:0010057)1.44210536
140Long eyelashes (HP:0000527)1.43333930
141Midline defect of the nose (HP:0004122)1.42810582
142Missing ribs (HP:0000921)1.42378779
143Hepatoblastoma (HP:0002884)1.40638328
144Cutis marmorata (HP:0000965)1.40185215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.97949181
2CDK122.74600895
3NEK12.55478334
4PLK42.50679024
5NEK22.38295518
6PBK2.29674892
7EIF2AK12.10023787
8MARK12.05419303
9PNCK1.97840780
10PLK31.86362678
11MAP3K41.84478462
12BUB11.83179246
13WEE11.75348827
14TTK1.67172834
15BRSK11.62434357
16SCYL21.61875941
17MAP3K91.58435457
18KSR11.58165854
19NTRK31.57664703
20BRSK21.46948637
21MINK11.45480045
22PAK61.44047818
23EEF2K1.38498533
24MKNK11.36981397
25ERBB31.35490861
26PKN21.35318525
27NTRK21.34579132
28CHEK21.32858058
29PRKD31.32702221
30SMG11.32303056
31BRD41.29302991
32PLK11.28283653
33PLK21.27948217
34CHEK11.22445361
35ATR1.22183219
36UHMK11.19740175
37LATS11.19429170
38CDK71.18880023
39ALK1.16025967
40CCNB11.13025092
41SRPK11.12539330
42TAF11.09264920
43FGFR11.08595209
44MET1.06054950
45CDK61.05401742
46TYRO31.03254411
47FGFR21.02949049
48KSR21.02249416
49ATM1.02134696
50MELK1.01480077
51LMTK21.01093958
52CAMK1G1.01085617
53AURKB1.00672047
54TSSK61.00075210
55BRAF0.97500536
56RIPK10.95788994
57MKNK20.94177751
58EIF2AK30.93706044
59PASK0.93587203
60NTRK10.93253526
61CDK10.93111448
62PDGFRA0.92010809
63CLK10.91017775
64CDK20.90136041
65SGK30.86231031
66SGK20.86148264
67EPHA40.85656947
68MAP3K100.84422341
69CDK180.80979704
70LATS20.80214901
71CDK150.80093474
72CAMKK10.79537227
73CSNK1A1L0.79132639
74CDK140.76304715
75CDK80.76102909
76PRKDC0.74425475
77WNK10.74000464
78MST1R0.73785915
79RET0.73525991
80CSNK1G20.72910418
81ERBB40.72212641
82CAMK1D0.71875477
83CSNK1D0.71705569
84STK30.70487333
85TRIB30.70160046
86EIF2AK20.69878386
87CDK40.69412392
88MAP3K80.68141189
89MAPK130.67322492
90CDK11A0.67067541
91MTOR0.66709182
92ZAK0.65484086
93SGK4940.64452006
94SGK2230.64452006
95TRIM280.63179849
96ICK0.63012808
97MAPK100.59758631
98TTN0.59691374
99SIK20.59643555
100CDC42BPA0.59617338
101SGK10.58368756
102GSK3B0.58111975
103CSNK1E0.56411239
104AURKA0.56369782
105MAPK140.55985896
106PTK60.55956480
107PTK20.55351010
108RAF10.54583132
109CSNK1G30.54307728
110CDK50.53968703
111PAK40.52645130
112STK40.52632575
113PDGFRB0.51661549
114RPS6KB20.51372249
115MAP3K20.51152959
116BCR0.49956908
117LIMK10.49788063
118CDK90.47605360
119TNIK0.47289814
120RPS6KB10.46994656
121PHKG10.45541391
122PHKG20.45541391
123NEK60.45162819
124PAK20.43123140
125RPS6KA40.41822335
126YES10.40729489
127CDK30.40520844
128STK38L0.40139628
129AKT20.38132048

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.12566101
2Oocyte meiosis_Homo sapiens_hsa041142.05890448
3Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.81472009
4mRNA surveillance pathway_Homo sapiens_hsa030151.80480804
5Alcoholism_Homo sapiens_hsa050341.61007326
6Long-term potentiation_Homo sapiens_hsa047201.59204696
7RNA transport_Homo sapiens_hsa030131.57711569
8One carbon pool by folate_Homo sapiens_hsa006701.54477858
9Thyroid cancer_Homo sapiens_hsa052161.53891751
10Systemic lupus erythematosus_Homo sapiens_hsa053221.47983282
11Nicotine addiction_Homo sapiens_hsa050331.46020567
12Lysine degradation_Homo sapiens_hsa003101.45023281
13Biosynthesis of amino acids_Homo sapiens_hsa012301.44987930
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42334456
15Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42201079
16Mismatch repair_Homo sapiens_hsa034301.40651174
17Colorectal cancer_Homo sapiens_hsa052101.37911463
18Dorso-ventral axis formation_Homo sapiens_hsa043201.35296470
19Circadian entrainment_Homo sapiens_hsa047131.34370611
20Dopaminergic synapse_Homo sapiens_hsa047281.31633704
21MicroRNAs in cancer_Homo sapiens_hsa052061.30784417
22Glioma_Homo sapiens_hsa052141.30235244
23Olfactory transduction_Homo sapiens_hsa047401.30027535
24Hippo signaling pathway_Homo sapiens_hsa043901.29873562
25Spliceosome_Homo sapiens_hsa030401.27224583
26Glutamatergic synapse_Homo sapiens_hsa047241.25880227
27Endometrial cancer_Homo sapiens_hsa052131.24940669
28mTOR signaling pathway_Homo sapiens_hsa041501.24219247
29DNA replication_Homo sapiens_hsa030301.22993351
30Basal cell carcinoma_Homo sapiens_hsa052171.21355581
31Fanconi anemia pathway_Homo sapiens_hsa034601.19315286
32Amphetamine addiction_Homo sapiens_hsa050311.19249706
33Basal transcription factors_Homo sapiens_hsa030221.18738342
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18609541
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18200089
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16744162
37Synaptic vesicle cycle_Homo sapiens_hsa047211.15964145
38Axon guidance_Homo sapiens_hsa043601.15954108
39Long-term depression_Homo sapiens_hsa047301.14819194
40Gap junction_Homo sapiens_hsa045401.14569231
41Hedgehog signaling pathway_Homo sapiens_hsa043401.12936407
42Estrogen signaling pathway_Homo sapiens_hsa049151.11819814
43Viral carcinogenesis_Homo sapiens_hsa052031.07728673
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07586563
45GABAergic synapse_Homo sapiens_hsa047271.07098216
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05062365
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05010707
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04238842
49Non-homologous end-joining_Homo sapiens_hsa034501.04054970
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03417102
51Morphine addiction_Homo sapiens_hsa050321.03214306
52Wnt signaling pathway_Homo sapiens_hsa043101.02746771
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02612418
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02388701
55Melanogenesis_Homo sapiens_hsa049161.01127832
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00707043
57ErbB signaling pathway_Homo sapiens_hsa040121.00564621
58Type II diabetes mellitus_Homo sapiens_hsa049300.99905091
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98810097
60Oxytocin signaling pathway_Homo sapiens_hsa049210.98212687
61Steroid biosynthesis_Homo sapiens_hsa001000.97671928
62Chronic myeloid leukemia_Homo sapiens_hsa052200.97436488
63Cholinergic synapse_Homo sapiens_hsa047250.97005747
64Carbon metabolism_Homo sapiens_hsa012000.96821633
65GnRH signaling pathway_Homo sapiens_hsa049120.95498684
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.95236473
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94805763
68Adherens junction_Homo sapiens_hsa045200.94408102
69Pyruvate metabolism_Homo sapiens_hsa006200.93927951
70Non-small cell lung cancer_Homo sapiens_hsa052230.93542701
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.91316921
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.90906694
73Gastric acid secretion_Homo sapiens_hsa049710.90761546
74Nucleotide excision repair_Homo sapiens_hsa034200.90080121
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89561996
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89513820
77Proteoglycans in cancer_Homo sapiens_hsa052050.88971808
78Insulin secretion_Homo sapiens_hsa049110.88608736
79Vitamin B6 metabolism_Homo sapiens_hsa007500.88254472
80Renal cell carcinoma_Homo sapiens_hsa052110.88076714
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88022764
82Salivary secretion_Homo sapiens_hsa049700.87955880
83TGF-beta signaling pathway_Homo sapiens_hsa043500.87700659
84Selenocompound metabolism_Homo sapiens_hsa004500.86165630
85Tight junction_Homo sapiens_hsa045300.84552706
86Renin secretion_Homo sapiens_hsa049240.84444649
87Phototransduction_Homo sapiens_hsa047440.83435858
88Homologous recombination_Homo sapiens_hsa034400.83356225
89HTLV-I infection_Homo sapiens_hsa051660.82430846
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81353902
91Base excision repair_Homo sapiens_hsa034100.81051928
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81030262
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80201025
94Pyrimidine metabolism_Homo sapiens_hsa002400.77100653
95Melanoma_Homo sapiens_hsa052180.76245877
96p53 signaling pathway_Homo sapiens_hsa041150.76092929
97RNA degradation_Homo sapiens_hsa030180.75745470
98MAPK signaling pathway_Homo sapiens_hsa040100.73442083
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73303450
100Pentose phosphate pathway_Homo sapiens_hsa000300.73149203
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72943492
102Pancreatic cancer_Homo sapiens_hsa052120.72869987
103Focal adhesion_Homo sapiens_hsa045100.72614296
104Cocaine addiction_Homo sapiens_hsa050300.72014493
105cAMP signaling pathway_Homo sapiens_hsa040240.71708963
106Small cell lung cancer_Homo sapiens_hsa052220.71155004
107Taste transduction_Homo sapiens_hsa047420.70085461
108Prostate cancer_Homo sapiens_hsa052150.70001734
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.69727762
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69675047
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69628102
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69140426
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68610648
114Bladder cancer_Homo sapiens_hsa052190.67844685
115Rap1 signaling pathway_Homo sapiens_hsa040150.67036771
116FoxO signaling pathway_Homo sapiens_hsa040680.66921626
117VEGF signaling pathway_Homo sapiens_hsa043700.66719421
118Dilated cardiomyopathy_Homo sapiens_hsa054140.65550705
119Thyroid hormone synthesis_Homo sapiens_hsa049180.64936673
120Pathways in cancer_Homo sapiens_hsa052000.64208021
121Viral myocarditis_Homo sapiens_hsa054160.62575777
122Choline metabolism in cancer_Homo sapiens_hsa052310.62531977
123AMPK signaling pathway_Homo sapiens_hsa041520.59091877
124ECM-receptor interaction_Homo sapiens_hsa045120.56526662
125N-Glycan biosynthesis_Homo sapiens_hsa005100.55724129
126Fatty acid biosynthesis_Homo sapiens_hsa000610.55592352
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55114171
128Insulin signaling pathway_Homo sapiens_hsa049100.53666778
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49707750
130RNA polymerase_Homo sapiens_hsa030200.48864165
131Inositol phosphate metabolism_Homo sapiens_hsa005620.48529059
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48403980
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47060227
134Purine metabolism_Homo sapiens_hsa002300.45184120
135Fatty acid metabolism_Homo sapiens_hsa012120.43686771
136Proteasome_Homo sapiens_hsa030500.42481374
137Propanoate metabolism_Homo sapiens_hsa006400.41689854
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39659449
139Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33170331

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