CKB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.15256836
2synaptic vesicle maturation (GO:0016188)5.03555956
3locomotory exploration behavior (GO:0035641)4.93101579
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.84590005
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.70287218
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.64104716
7sodium ion export (GO:0071436)4.55401220
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.49649471
9vocalization behavior (GO:0071625)4.48741707
10cellular potassium ion homeostasis (GO:0030007)4.41617540
11glutamate secretion (GO:0014047)4.33389189
12regulation of synaptic vesicle exocytosis (GO:2000300)4.29469972
13protein localization to synapse (GO:0035418)4.29230418
14axon ensheathment in central nervous system (GO:0032291)4.28604403
15central nervous system myelination (GO:0022010)4.28604403
16neuron cell-cell adhesion (GO:0007158)4.26917542
17layer formation in cerebral cortex (GO:0021819)4.25783751
18neurotransmitter-gated ion channel clustering (GO:0072578)4.12850262
19regulation of synapse structural plasticity (GO:0051823)4.12400659
20neuronal action potential propagation (GO:0019227)4.05098154
21regulation of glutamate receptor signaling pathway (GO:1900449)3.99717970
22neurotransmitter secretion (GO:0007269)3.99506408
23gamma-aminobutyric acid transport (GO:0015812)3.97611841
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.97058477
25establishment of mitochondrion localization (GO:0051654)3.91876635
26cerebellar granule cell differentiation (GO:0021707)3.87109698
27positive regulation of synapse maturation (GO:0090129)3.85706825
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.85079202
29synaptic transmission, glutamatergic (GO:0035249)3.83977377
30pyrimidine nucleobase catabolic process (GO:0006208)3.80854869
31innervation (GO:0060384)3.79059281
32response to auditory stimulus (GO:0010996)3.77154566
33ionotropic glutamate receptor signaling pathway (GO:0035235)3.76162471
34G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.75994382
35regulation of neuronal synaptic plasticity (GO:0048168)3.68531505
36glutamate receptor signaling pathway (GO:0007215)3.67827009
37regulation of synaptic vesicle transport (GO:1902803)3.67002648
38dendritic spine morphogenesis (GO:0060997)3.66436969
39L-amino acid import (GO:0043092)3.64775120
40positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.63954345
41exploration behavior (GO:0035640)3.63539097
42neuron-neuron synaptic transmission (GO:0007270)3.62030505
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60553016
44auditory behavior (GO:0031223)3.58000559
45regulation of long-term neuronal synaptic plasticity (GO:0048169)3.57721457
46dendritic spine organization (GO:0097061)3.48698522
47transmission of nerve impulse (GO:0019226)3.46957895
48cell communication by electrical coupling (GO:0010644)3.46893498
49long-term synaptic potentiation (GO:0060291)3.45425943
50regulation of synaptic transmission, glutamatergic (GO:0051966)3.43437454
51presynaptic membrane assembly (GO:0097105)3.41096132
52potassium ion homeostasis (GO:0055075)3.38358958
53neuromuscular process controlling balance (GO:0050885)3.34379878
54negative regulation of cytosolic calcium ion concentration (GO:0051481)3.33510082
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.33290612
56amino acid import (GO:0043090)3.33000579
57long-term memory (GO:0007616)3.32194669
58neurotransmitter transport (GO:0006836)3.29226482
59mitochondrion transport along microtubule (GO:0047497)3.27597080
60establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.27597080
61response to pheromone (GO:0019236)3.27530170
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26493066
63prepulse inhibition (GO:0060134)3.26058912
64positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25305399
65cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.22465133
66synaptic vesicle endocytosis (GO:0048488)3.20769501
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.20205565
68membrane hyperpolarization (GO:0060081)3.19422755
69regulation of synaptic plasticity (GO:0048167)3.12798810
70cerebral cortex neuron differentiation (GO:0021895)3.11959428
71axonal fasciculation (GO:0007413)3.11711251
72positive regulation of membrane potential (GO:0045838)3.10425980
73cerebellar Purkinje cell differentiation (GO:0021702)3.09616408
74negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07771976
75regulation of excitatory postsynaptic membrane potential (GO:0060079)3.06709235
76regulation of neurotransmitter levels (GO:0001505)3.05886437
77regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.05345457
78neuron recognition (GO:0008038)3.04099635
79adult walking behavior (GO:0007628)3.03815469
80nucleobase catabolic process (GO:0046113)3.03441426
81positive regulation of dendritic spine development (GO:0060999)3.03347737
82C4-dicarboxylate transport (GO:0015740)3.02546016
83regulation of neurotransmitter secretion (GO:0046928)3.01750780
84regulation of synapse maturation (GO:0090128)3.00458617
85establishment of nucleus localization (GO:0040023)3.00130896
86regulation of dendritic spine morphogenesis (GO:0061001)3.00129690
87regulation of respiratory gaseous exchange (GO:0043576)2.99970488
88regulation of voltage-gated calcium channel activity (GO:1901385)2.99685689
89neuronal ion channel clustering (GO:0045161)2.98711744
90postsynaptic membrane organization (GO:0001941)2.97763435
91neuromuscular process controlling posture (GO:0050884)2.97600037
92membrane repolarization (GO:0086009)2.96887324
93regulation of postsynaptic membrane potential (GO:0060078)2.96029819
94regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95450614
95dendrite morphogenesis (GO:0048813)2.94316219
96positive regulation of potassium ion transmembrane transport (GO:1901381)2.94129828
97spinal cord association neuron differentiation (GO:0021527)2.93088967
98glycine transport (GO:0015816)2.92573598
99regulation of neurotransmitter transport (GO:0051588)2.92412277
100potassium ion import (GO:0010107)2.91368915
101positive regulation of synapse assembly (GO:0051965)2.91255578
102mating behavior (GO:0007617)2.89787180
103neuronal stem cell maintenance (GO:0097150)2.89666567
104cellular sodium ion homeostasis (GO:0006883)2.89381605
105mechanosensory behavior (GO:0007638)2.89285846
106presynaptic membrane organization (GO:0097090)2.88239090
107substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.87612088
108substrate-independent telencephalic tangential migration (GO:0021826)2.87612088
109cell migration in hindbrain (GO:0021535)2.86681112
110neuroblast proliferation (GO:0007405)2.85782969
111cerebellar Purkinje cell layer development (GO:0021680)2.84033499
112negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.83953521
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.83739124
114acidic amino acid transport (GO:0015800)2.75797905
115positive regulation of neurotransmitter transport (GO:0051590)2.74286814
116neuromuscular synaptic transmission (GO:0007274)2.72694896
117establishment of synaptic vesicle localization (GO:0097480)2.72400081
118synaptic vesicle transport (GO:0048489)2.72400081
119regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.62408393
120negative regulation of oligodendrocyte differentiation (GO:0048715)2.61687480
121regulation of respiratory system process (GO:0044065)2.60741052
122neurotransmitter uptake (GO:0001504)2.52493660
123negative regulation of microtubule polymerization (GO:0031115)2.52322020
124synapse assembly (GO:0007416)2.50616851
125L-glutamate transport (GO:0015813)2.50230311
126regulation of vesicle fusion (GO:0031338)2.50005671
127behavioral response to cocaine (GO:0048148)2.49704477
128regulation of dendritic spine development (GO:0060998)2.48177756
129dicarboxylic acid transport (GO:0006835)2.45883426

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.18807811
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.40237628
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.28706916
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.27809650
5EZH2_18974828_ChIP-Seq_MESCs_Mouse3.06521080
6RNF2_18974828_ChIP-Seq_MESCs_Mouse3.06521080
7JARID2_20075857_ChIP-Seq_MESCs_Mouse3.02063271
8GBX2_23144817_ChIP-Seq_PC3_Human2.96776217
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.93694124
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.91190638
11REST_21632747_ChIP-Seq_MESCs_Mouse2.78521846
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.74634521
13* RARB_27405468_Chip-Seq_BRAIN_Mouse2.73882498
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.69037525
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68718639
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.67194819
17DROSHA_22980978_ChIP-Seq_HELA_Human2.67169669
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.61460189
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.61292584
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.59490574
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.57699672
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.42785606
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30548872
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29174526
25AR_21572438_ChIP-Seq_LNCaP_Human2.19630157
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16648939
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.13852406
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13262244
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09938227
30ERG_21242973_ChIP-ChIP_JURKAT_Human2.03236802
31IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00385768
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97190515
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.94571984
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78257213
35RING1B_27294783_Chip-Seq_ESCs_Mouse1.70914002
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70810738
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.68718296
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57994883
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56738881
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.55122954
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47836205
42RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45382710
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41981655
44* RING1B_27294783_Chip-Seq_NPCs_Mouse1.40465894
45SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.39925930
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36919897
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36852163
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35577077
49OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.34733316
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33162640
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.28143058
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25575397
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25565223
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22437403
55* KDM2B_26808549_Chip-Seq_K562_Human1.20324687
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18335790
57* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18083901
58P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17590451
59* XRN2_22483619_ChIP-Seq_HELA_Human1.17183244
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16401744
61* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16346002
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14644236
63AR_19668381_ChIP-Seq_PC3_Human1.14430016
64SMAD4_21799915_ChIP-Seq_A2780_Human1.14364063
65ZNF274_21170338_ChIP-Seq_K562_Hela1.14346944
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13736307
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13090953
68* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13058701
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12607218
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.09846415
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09248105
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.09206400
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09132091
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07521899
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05945415
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05848766
77CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05783830
78* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.05579407
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04831281
80SOX3_22085726_ChIP-Seq_NPCs_Mouse1.03231235
81* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03121521
82EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02384688
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02316693
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01694871
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01475843
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00989540
87SMAD3_21741376_ChIP-Seq_ESCs_Human1.00570254
88GATA1_26923725_Chip-Seq_HPCs_Mouse0.99275731
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99065677
90YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98213408
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97089056
92BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95886784
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95641453
94LXR_22292898_ChIP-Seq_THP-1_Human0.94711068
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93172201
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.91563361
97TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91379589
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90918435
99TET1_21490601_ChIP-Seq_MESCs_Mouse0.90894403
100* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.90446046
101RUNX1_26923725_Chip-Seq_HPCs_Mouse0.90121794
102CTCF_27219007_Chip-Seq_Bcells_Human0.89651950
103TET1_21451524_ChIP-Seq_MESCs_Mouse0.88824094
104AR_25329375_ChIP-Seq_VCAP_Human0.88536262
105STAT3_23295773_ChIP-Seq_U87_Human0.88326090
106* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88135031
107CREB1_26743006_Chip-Seq_LNCaP_Human0.88041062
108* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87831249
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.87441005
110* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87422802
111P300_19829295_ChIP-Seq_ESCs_Human0.87237461
112P68_20966046_ChIP-Seq_HELA_Human0.87133590
113POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86521513
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85913414
115* RNF2_27304074_Chip-Seq_NSC_Mouse0.85425903
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85266093
117TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83389477
118YY1_21170310_ChIP-Seq_MESCs_Mouse0.82963583
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82938164
120TAF15_26573619_Chip-Seq_HEK293_Human0.82724910
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.82282460
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.82155106
123TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82028222
124* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81145726
125MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.80832795
126NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.79527252
127ZFP57_27257070_Chip-Seq_ESCs_Mouse0.79425551
128POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79098571
129PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.78225896
130* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78066570
131TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77811160
132* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77226517
133* KLF4_19829295_ChIP-Seq_ESCs_Human0.77058241
134SOX9_26525672_Chip-Seq_HEART_Mouse0.76974077
135* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.76143957
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.76089661
137* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75943330
138GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75798913
139SMC4_20622854_ChIP-Seq_HELA_Human0.75240548
140PIAS1_25552417_ChIP-Seq_VCAP_Human0.74334219
141SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.73289347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.23108293
2MP0003880_abnormal_central_pattern3.87583855
3MP0003635_abnormal_synaptic_transmissio3.57675074
4* MP0002064_seizures3.00006753
5MP0009046_muscle_twitch2.98541132
6MP0002653_abnormal_ependyma_morphology2.96915647
7MP0004270_analgesia2.90808706
8* MP0009745_abnormal_behavioral_response2.90580776
9* MP0002063_abnormal_learning/memory/cond2.82786848
10MP0005423_abnormal_somatic_nervous2.56857727
11* MP0001486_abnormal_startle_reflex2.51483792
12MP0002272_abnormal_nervous_system2.43709491
13MP0000778_abnormal_nervous_system2.41362234
14* MP0002572_abnormal_emotion/affect_behav2.40927235
15MP0001968_abnormal_touch/_nociception2.39236092
16MP0002822_catalepsy2.34993939
17MP0001984_abnormal_olfaction2.29058044
18MP0004858_abnormal_nervous_system2.27580218
19MP0002734_abnormal_mechanical_nocicepti2.20029702
20MP0001529_abnormal_vocalization2.16633933
21MP0003329_amyloid_beta_deposits2.16129496
22MP0002736_abnormal_nociception_after2.08933309
23MP0002067_abnormal_sensory_capabilities2.03301008
24MP0008569_lethality_at_weaning1.98206344
25MP0005646_abnormal_pituitary_gland1.94952530
26MP0004885_abnormal_endolymph1.94605805
27MP0004142_abnormal_muscle_tone1.89054320
28MP0000566_synostosis1.88680664
29MP0005551_abnormal_eye_electrophysiolog1.85708468
30MP0000955_abnormal_spinal_cord1.84028722
31MP0001502_abnormal_circadian_rhythm1.82312341
32MP0001346_abnormal_lacrimal_gland1.81207208
33MP0001440_abnormal_grooming_behavior1.75730250
34MP0003634_abnormal_glial_cell1.72664283
35* MP0002557_abnormal_social/conspecific_i1.70286768
36MP0002184_abnormal_innervation1.69650587
37MP0002733_abnormal_thermal_nociception1.68241228
38MP0001970_abnormal_pain_threshold1.65062791
39MP0002882_abnormal_neuron_morphology1.62939288
40MP0002249_abnormal_larynx_morphology1.59833924
41MP0001501_abnormal_sleep_pattern1.58851632
42MP0004924_abnormal_behavior1.56346427
43MP0005386_behavior/neurological_phenoty1.56346427
44MP0004133_heterotaxia1.56296987
45MP0004811_abnormal_neuron_physiology1.52531071
46MP0003787_abnormal_imprinting1.51627726
47MP0009780_abnormal_chondrocyte_physiolo1.50987376
48MP0003123_paternal_imprinting1.46594169
49MP0003690_abnormal_glial_cell1.44486674
50MP0002735_abnormal_chemical_nociception1.44052359
51MP0002234_abnormal_pharynx_morphology1.43192442
52MP0002066_abnormal_motor_capabilities/c1.41440804
53* MP0002152_abnormal_brain_morphology1.37331280
54MP0002090_abnormal_vision1.37041269
55MP0006072_abnormal_retinal_apoptosis1.36825356
56MP0002909_abnormal_adrenal_gland1.30345009
57MP0003633_abnormal_nervous_system1.26848322
58MP0003938_abnormal_ear_development1.26769331
59MP0000049_abnormal_middle_ear1.24678077
60MP0003136_yellow_coat_color1.22143220
61MP0005394_taste/olfaction_phenotype1.21417868
62MP0005499_abnormal_olfactory_system1.21417868
63MP0001188_hyperpigmentation1.20933416
64MP0003283_abnormal_digestive_organ1.20473166
65MP0000631_abnormal_neuroendocrine_gland1.19271979
66MP0000920_abnormal_myelination1.17681302
67MP0003631_nervous_system_phenotype1.16326429
68MP0000537_abnormal_urethra_morphology1.15312691
69MP0003632_abnormal_nervous_system1.15288199
70MP0001485_abnormal_pinna_reflex1.12968299
71MP0002089_abnormal_postnatal_growth/wei1.12798921
72MP0002752_abnormal_somatic_nervous1.12625490
73MP0002229_neurodegeneration1.12026402
74MP0005253_abnormal_eye_physiology1.11712433
75MP0004742_abnormal_vestibular_system1.09658104
76MP0003121_genomic_imprinting1.08915291
77MP0002638_abnormal_pupillary_reflex1.08223969
78MP0005645_abnormal_hypothalamus_physiol1.07983213
79MP0006276_abnormal_autonomic_nervous1.07310840
80MP0001905_abnormal_dopamine_level1.04709566
81MP0004233_abnormal_muscle_weight1.00009178
82MP0003861_abnormal_nervous_system0.97910712
83MP0010030_abnormal_orbit_morphology0.92617322
84MP0002069_abnormal_eating/drinking_beha0.92086596
85MP0001177_atelectasis0.91096071
86MP0002233_abnormal_nose_morphology0.89585844
87MP0001963_abnormal_hearing_physiology0.88753891
88MP0003137_abnormal_impulse_conducting0.88307029
89MP0004145_abnormal_muscle_electrophysio0.88043678
90MP0008961_abnormal_basal_metabolism0.86809358
91MP0003879_abnormal_hair_cell0.86668643
92MP0005195_abnormal_posterior_eye0.86407730
93MP0002751_abnormal_autonomic_nervous0.85752278
94MP0000751_myopathy0.85593243
95MP0000604_amyloidosis0.84408047
96MP0005623_abnormal_meninges_morphology0.84314727
97MP0000026_abnormal_inner_ear0.81962477
98MP0003122_maternal_imprinting0.81267658
99MP0001293_anophthalmia0.79763362
100MP0008872_abnormal_physiological_respon0.79557990
101MP0008932_abnormal_embryonic_tissue0.76148957
102MP0001299_abnormal_eye_distance/0.75618033
103MP0001943_abnormal_respiration0.74434955
104MP0003075_altered_response_to0.73767275
105MP0000681_abnormal_thyroid_gland0.72910646
106MP0002081_perinatal_lethality0.72070529
107MP0003119_abnormal_digestive_system0.71266800
108MP0005171_absent_coat_pigmentation0.69949062
109MP0005391_vision/eye_phenotype0.69479265
110MP0002938_white_spotting0.69474323
111MP0003315_abnormal_perineum_morphology0.67209579
112MP0008789_abnormal_olfactory_epithelium0.67198195
113MP0000013_abnormal_adipose_tissue0.65438788
114MP0010769_abnormal_survival0.65107790
115MP0004085_abnormal_heartbeat0.63672767
116MP0010770_preweaning_lethality0.62923231
117MP0002082_postnatal_lethality0.62923231
118MP0010768_mortality/aging0.60921366
119MP0006292_abnormal_olfactory_placode0.60106585
120MP0005187_abnormal_penis_morphology0.59421042
121MP0003183_abnormal_peptide_metabolism0.59309141
122MP0004215_abnormal_myocardial_fiber0.58730993

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.06282726
2Focal motor seizures (HP:0011153)5.18313206
3Megalencephaly (HP:0001355)4.41441000
4Focal seizures (HP:0007359)4.24510991
5Epileptic encephalopathy (HP:0200134)4.19671372
6Progressive cerebellar ataxia (HP:0002073)4.02831573
7Visual hallucinations (HP:0002367)3.76853046
8Action tremor (HP:0002345)3.60289797
9Atonic seizures (HP:0010819)3.35801848
10Congenital malformation of the right heart (HP:0011723)3.26313094
11Double outlet right ventricle (HP:0001719)3.26313094
12Absence seizures (HP:0002121)3.26070760
13Supranuclear gaze palsy (HP:0000605)3.18830699
14Neurofibrillary tangles (HP:0002185)3.08488485
15Hemiparesis (HP:0001269)3.06118729
16Febrile seizures (HP:0002373)3.05857403
17Dysdiadochokinesis (HP:0002075)3.03366759
18Dialeptic seizures (HP:0011146)3.02622859
19Ankle clonus (HP:0011448)2.91910215
20Aplasia involving bones of the extremities (HP:0009825)2.89553258
21Aplasia involving bones of the upper limbs (HP:0009823)2.89553258
22Aplasia of the phalanges of the hand (HP:0009802)2.89553258
23Septo-optic dysplasia (HP:0100842)2.85949754
24Depression (HP:0000716)2.78774842
25Truncal ataxia (HP:0002078)2.74559810
26Generalized tonic-clonic seizures (HP:0002069)2.74313815
27Hemiplegia (HP:0002301)2.71270532
28Split foot (HP:0001839)2.70358685
29Abnormal eating behavior (HP:0100738)2.64051261
30Cerebral inclusion bodies (HP:0100314)2.59625848
31Dysmetria (HP:0001310)2.58084274
32Pheochromocytoma (HP:0002666)2.55179182
33Amblyopia (HP:0000646)2.52578680
34Anxiety (HP:0000739)2.49173007
35Central scotoma (HP:0000603)2.48774524
36Broad-based gait (HP:0002136)2.48132045
37Scanning speech (HP:0002168)2.47868357
38Scotoma (HP:0000575)2.45044170
39Abnormality of the aortic arch (HP:0012303)2.41845168
40Gaze-evoked nystagmus (HP:0000640)2.41753325
41Intention tremor (HP:0002080)2.27741129
42Abnormality of the parathyroid morphology (HP:0011766)2.27431811
43Congenital stationary night blindness (HP:0007642)2.26033925
44Hepatoblastoma (HP:0002884)2.25609665
45Insomnia (HP:0100785)2.25367497
46Impaired vibration sensation in the lower limbs (HP:0002166)2.24687826
47Spastic gait (HP:0002064)2.24243371
48Limb dystonia (HP:0002451)2.21745617
49Oligodactyly (hands) (HP:0001180)2.19101257
50Diplopia (HP:0000651)2.17636216
51Abnormality of binocular vision (HP:0011514)2.17636216
52Epileptiform EEG discharges (HP:0011182)2.17183722
53Poor eye contact (HP:0000817)2.16362002
54EEG with generalized epileptiform discharges (HP:0011198)2.15311908
55Anomalous pulmonary venous return (HP:0010772)2.14672267
56Broad distal phalanx of finger (HP:0009836)2.13248959
57Hyperventilation (HP:0002883)2.11271900
58Abnormality of the labia minora (HP:0012880)2.09631598
59Abnormality of the lower motor neuron (HP:0002366)2.07490910
60Neuroendocrine neoplasm (HP:0100634)2.06916970
61Neoplasm of the heart (HP:0100544)2.04409504
62Cortical dysplasia (HP:0002539)2.04101657
63Urinary urgency (HP:0000012)2.04026943
64Postural instability (HP:0002172)2.03764469
65Retinal dysplasia (HP:0007973)2.03708569
66Hypsarrhythmia (HP:0002521)2.02658844
67Urinary bladder sphincter dysfunction (HP:0002839)2.02376240
68Peripheral hypomyelination (HP:0007182)2.01491373
69Genetic anticipation (HP:0003743)2.01349486
70Morphological abnormality of the inner ear (HP:0011390)2.01207623
71Insidious onset (HP:0003587)1.98627516
72Termporal pattern (HP:0011008)1.98627516
73Abnormal social behavior (HP:0012433)1.98525717
74Impaired social interactions (HP:0000735)1.98525717
75Lower limb muscle weakness (HP:0007340)1.98421296
76Annular pancreas (HP:0001734)1.97856198
77Synostosis involving the elbow (HP:0003938)1.96575181
78Humeroradial synostosis (HP:0003041)1.96575181
79Torticollis (HP:0000473)1.95240454
80Pointed chin (HP:0000307)1.94563438
81Thickened helices (HP:0000391)1.93670230
82Specific learning disability (HP:0001328)1.93609250
83Delusions (HP:0000746)1.93265742
84Cutaneous finger syndactyly (HP:0010554)1.91988690
85Renal dysplasia (HP:0000110)1.91840156
86Rib fusion (HP:0000902)1.91396855
87Alacrima (HP:0000522)1.91129935
88Hemivertebrae (HP:0002937)1.90027687
89Focal dystonia (HP:0004373)1.87837565
90Abnormality of macular pigmentation (HP:0008002)1.86181478
91Cerebral hypomyelination (HP:0006808)1.85416109
92Partial duplication of thumb phalanx (HP:0009944)1.85380570
93Gait imbalance (HP:0002141)1.84579948
94Abnormality of glycolysis (HP:0004366)1.83723756
95Oligodactyly (HP:0012165)1.83689391
96Sleep apnea (HP:0010535)1.83672553
97Absent septum pellucidum (HP:0001331)1.83314110
98Cutaneous syndactyly (HP:0012725)1.83224291
99Status epilepticus (HP:0002133)1.82415686
100Drooling (HP:0002307)1.82308959
101Excessive salivation (HP:0003781)1.82308959
102Stereotypic behavior (HP:0000733)1.82035905
103Fetal akinesia sequence (HP:0001989)1.81616484
104Polyphagia (HP:0002591)1.80707848
105Mutism (HP:0002300)1.80321988
106Clumsiness (HP:0002312)1.76563503
107Dysphonia (HP:0001618)1.76250599
108Bifid scrotum (HP:0000048)1.75852407
109Abnormality of the pulmonary veins (HP:0011718)1.75851820
110Impaired smooth pursuit (HP:0007772)1.75686437
111Tetraplegia (HP:0002445)1.75610183
112Athetosis (HP:0002305)1.75476752
113Abnormal ventriculo-arterial connection (HP:0011563)1.75372230
114Transposition of the great arteries (HP:0001669)1.75372230
115Abnormal connection of the cardiac segments (HP:0011545)1.75372230
116Incomplete penetrance (HP:0003829)1.75322536
117Preauricular pit (HP:0004467)1.75182610
118Periauricular skin pits (HP:0100277)1.75182610
119CNS hypomyelination (HP:0003429)1.74210672
120Truncus arteriosus (HP:0001660)1.74174107
121Occipital encephalocele (HP:0002085)1.73752572
122Ventricular fibrillation (HP:0001663)1.73186395
123Maternal diabetes (HP:0009800)1.72110411
124Neoplasm of the peripheral nervous system (HP:0100007)1.71577002
125Abnormality of the corticospinal tract (HP:0002492)1.70377213
126Spastic tetraparesis (HP:0001285)1.70248671
127Abnormality of ocular smooth pursuit (HP:0000617)1.69920650
128Abnormality of cochlea (HP:0000375)1.69161815
129Anophthalmia (HP:0000528)1.68489579
130Bradykinesia (HP:0002067)1.68269551
131Adactyly (HP:0009776)1.68057822
132Esophageal atresia (HP:0002032)1.67499853
133Clonus (HP:0002169)1.67048579
134Congenital primary aphakia (HP:0007707)1.66773281
135Lower limb asymmetry (HP:0100559)1.65961849
136Gait ataxia (HP:0002066)1.65728625
137Neuronal loss in central nervous system (HP:0002529)1.65507460
138Generalized myoclonic seizures (HP:0002123)1.63651534
139Renal hypoplasia (HP:0000089)1.63369764
140Vitreoretinal degeneration (HP:0000655)1.61039255
141Turricephaly (HP:0000262)1.57930722
142Hyperglycinemia (HP:0002154)1.57035719
143Obstructive sleep apnea (HP:0002870)1.56262858
144Poor suck (HP:0002033)1.55187895

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.26559459
2NTRK32.92053509
3CAMKK12.89142818
4PAK62.80164252
5MAP3K92.73481152
6NTRK22.61089153
7KSR12.41727543
8PASK2.41191269
9MINK12.33720544
10MARK12.30934160
11TYRO32.08350593
12PRKD32.01597619
13LMTK22.01552215
14MAP3K42.00074608
15CASK1.91729943
16PRPF4B1.89814775
17KSR21.77729412
18DAPK21.77634271
19PHKG11.72504344
20PHKG21.72504344
21CDK191.66942294
22NTRK11.60833102
23UHMK11.60653832
24TNIK1.57849506
25CDK51.42321879
26DYRK21.36781941
27CDK181.34429412
28CSNK1A1L1.31547280
29CDK141.30244711
30CDK151.30186827
31PLK21.26273732
32NEK11.26235186
33MAPK131.25180316
34CAMK1D1.24935509
35TESK21.24468242
36MAP2K71.21094413
37NEK61.19904513
38SGK2231.19157520
39SGK4941.19157520
40OXSR11.17054833
41ROCK21.16739822
42CDK11A1.16080496
43ARAF1.16050020
44CAMK1G1.13761053
45LIMK11.12700121
46BCKDK1.11429180
47PRKCG1.07898385
48CSNK1G11.07019573
49BCR1.04354305
50STK381.03634143
51DYRK1A1.03544704
52BRSK11.01464551
53SIK31.00699787
54ICK0.99436597
55PNCK0.97047661
56BUB10.96132001
57CAMKK20.94066594
58BRAF0.86833767
59SRPK10.83475053
60DAPK10.83435512
61DYRK1B0.83218148
62CAMK2B0.82816228
63FES0.82657497
64PAK30.82249554
65PINK10.81939887
66EEF2K0.81730951
67CAMK2A0.80066100
68LATS20.78026355
69MAP3K130.77315409
70TRIB30.75567350
71GRK50.72598517
72WNK30.71988714
73ERBB20.71988161
74SIK20.71379999
75MARK20.69076489
76CAMK40.69030137
77PBK0.66013027
78MAP2K40.65601990
79PLK30.64024415
80PRKCZ0.63418848
81CAMK2D0.62649893
82PRKCH0.62610990
83STK110.61826283
84WEE10.61331137
85CDC42BPA0.60135719
86CAMK2G0.59179994
87RIPK40.59163104
88CSNK1G20.58241328
89MAP4K20.58168697
90TRIM280.56966548
91SGK20.56180326
92CCNB10.55970050
93MAPK150.55405418
94DYRK30.55068680
95AURKA0.54921111
96ROCK10.54264812
97TAOK10.51521197
98STK390.51405802
99FGR0.49322160
100AKT20.49023870
101MOS0.48066603
102TESK10.47841134
103MAP3K110.47583959
104PKN10.47417993
105CSNK1E0.47189644
106FYN0.46661678
107PLK40.46647001
108TTK0.46413793
109RPS6KA30.46355904
110PRKAA10.46309816
111ALK0.45451743
112PLK10.45196357
113MAPK100.44216820
114BMX0.43936672
115RET0.43911608
116IRAK20.43233675
117RIPK10.42860388
118SGK30.42796571
119SCYL20.40899025
120FGFR20.40439179
121CDK30.40172471
122PRKCE0.40071705
123RAF10.40020720
124EPHB20.39975151
125DDR20.39542772
126WNK10.39276943
127SGK10.38834068
128DAPK30.38237924
129SIK10.38033319
130CAMK10.36769853
131CSNK1G30.36131195
132MAP3K120.35758163

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.64992553
2Synaptic vesicle cycle_Homo sapiens_hsa047213.42133673
3GABAergic synapse_Homo sapiens_hsa047272.99275998
4Olfactory transduction_Homo sapiens_hsa047402.83225087
5Circadian entrainment_Homo sapiens_hsa047132.55988935
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55139305
7Morphine addiction_Homo sapiens_hsa050322.53660935
8Glutamatergic synapse_Homo sapiens_hsa047242.49069653
9Nitrogen metabolism_Homo sapiens_hsa009102.19419706
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13943779
11Salivary secretion_Homo sapiens_hsa049702.05284429
12Long-term potentiation_Homo sapiens_hsa047202.01690547
13Amphetamine addiction_Homo sapiens_hsa050311.91929703
14Dopaminergic synapse_Homo sapiens_hsa047281.87098103
15Insulin secretion_Homo sapiens_hsa049111.82194511
16Gastric acid secretion_Homo sapiens_hsa049711.77250573
17Cholinergic synapse_Homo sapiens_hsa047251.70843329
18Steroid biosynthesis_Homo sapiens_hsa001001.57738186
19Cocaine addiction_Homo sapiens_hsa050301.56440942
20Collecting duct acid secretion_Homo sapiens_hsa049661.54476069
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54395177
22Long-term depression_Homo sapiens_hsa047301.54182971
23Gap junction_Homo sapiens_hsa045401.51994141
24Oxytocin signaling pathway_Homo sapiens_hsa049211.51923905
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51157364
26Taste transduction_Homo sapiens_hsa047421.48155357
27Sulfur relay system_Homo sapiens_hsa041221.48076061
28Renin secretion_Homo sapiens_hsa049241.46457455
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45223413
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45155437
31Serotonergic synapse_Homo sapiens_hsa047261.42476572
32Calcium signaling pathway_Homo sapiens_hsa040201.36044230
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34107870
34Axon guidance_Homo sapiens_hsa043601.32705219
35* Arginine and proline metabolism_Homo sapiens_hsa003301.25002820
36Phototransduction_Homo sapiens_hsa047441.24075531
37Cardiac muscle contraction_Homo sapiens_hsa042601.20853782
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16493297
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13875678
40cAMP signaling pathway_Homo sapiens_hsa040241.13791565
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13252887
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11722414
43GnRH signaling pathway_Homo sapiens_hsa049121.11267565
44Melanogenesis_Homo sapiens_hsa049161.08787472
45Glioma_Homo sapiens_hsa052141.04149578
46Dorso-ventral axis formation_Homo sapiens_hsa043201.02950076
47Carbon metabolism_Homo sapiens_hsa012001.00633700
48Fatty acid biosynthesis_Homo sapiens_hsa000611.00279008
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98224359
50Vibrio cholerae infection_Homo sapiens_hsa051100.96230286
51Circadian rhythm_Homo sapiens_hsa047100.94181033
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93819815
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93262025
54Estrogen signaling pathway_Homo sapiens_hsa049150.92708567
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90026041
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89015002
57Fatty acid metabolism_Homo sapiens_hsa012120.89003175
58Pyruvate metabolism_Homo sapiens_hsa006200.88818215
59ErbB signaling pathway_Homo sapiens_hsa040120.86769583
60Hedgehog signaling pathway_Homo sapiens_hsa043400.86736191
61Oocyte meiosis_Homo sapiens_hsa041140.85458589
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.85083481
63Propanoate metabolism_Homo sapiens_hsa006400.82500971
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81637254
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.80212180
66Huntingtons disease_Homo sapiens_hsa050160.79520803
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76084489
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75666408
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75508410
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74621328
71beta-Alanine metabolism_Homo sapiens_hsa004100.73527478
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.72608544
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72209960
74Type II diabetes mellitus_Homo sapiens_hsa049300.70077529
75Dilated cardiomyopathy_Homo sapiens_hsa054140.69558015
76Alcoholism_Homo sapiens_hsa050340.69427056
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.67773859
78Pancreatic secretion_Homo sapiens_hsa049720.67130595
79Basal cell carcinoma_Homo sapiens_hsa052170.67009831
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66467219
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65901491
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64346687
83Folate biosynthesis_Homo sapiens_hsa007900.64291264
84AMPK signaling pathway_Homo sapiens_hsa041520.62593869
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61890223
86Fatty acid elongation_Homo sapiens_hsa000620.60280147
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59933783
88Wnt signaling pathway_Homo sapiens_hsa043100.59390665
89Renal cell carcinoma_Homo sapiens_hsa052110.59381347
90Prion diseases_Homo sapiens_hsa050200.59228401
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58981015
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58027140
93Base excision repair_Homo sapiens_hsa034100.57899270
94Spliceosome_Homo sapiens_hsa030400.57508119
95Hippo signaling pathway_Homo sapiens_hsa043900.55882660
96Arginine biosynthesis_Homo sapiens_hsa002200.55502670
97Notch signaling pathway_Homo sapiens_hsa043300.55322803
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55165547
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55019949
100Thyroid hormone synthesis_Homo sapiens_hsa049180.53900876
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53545248
102Bile secretion_Homo sapiens_hsa049760.49426202
103Choline metabolism in cancer_Homo sapiens_hsa052310.49364972
104Endocytosis_Homo sapiens_hsa041440.48563306
105Biosynthesis of amino acids_Homo sapiens_hsa012300.47724199
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.46838954
107Cell cycle_Homo sapiens_hsa041100.46327848
108MAPK signaling pathway_Homo sapiens_hsa040100.46307014
109Vitamin B6 metabolism_Homo sapiens_hsa007500.46100321
110Endometrial cancer_Homo sapiens_hsa052130.45808343
111Alzheimers disease_Homo sapiens_hsa050100.45507759
112Oxidative phosphorylation_Homo sapiens_hsa001900.44311835
113Tight junction_Homo sapiens_hsa045300.43980237
114Non-small cell lung cancer_Homo sapiens_hsa052230.43836732
115Parkinsons disease_Homo sapiens_hsa050120.43625368
116Butanoate metabolism_Homo sapiens_hsa006500.41900450
117Lysine degradation_Homo sapiens_hsa003100.41489564
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41257883
119Rap1 signaling pathway_Homo sapiens_hsa040150.41214155
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41192070
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.40333727
122Glucagon signaling pathway_Homo sapiens_hsa049220.40116745
123Ras signaling pathway_Homo sapiens_hsa040140.38398995
124Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37886356
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37727211
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37590338
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37214740
128Phenylalanine metabolism_Homo sapiens_hsa003600.37076368
129mTOR signaling pathway_Homo sapiens_hsa041500.37030886
130mRNA surveillance pathway_Homo sapiens_hsa030150.36456137

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