ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	9.62639217
2	lipopolysaccharide biosynthetic process (GO:0009103)	8.91114322
3	DNA methylation involved in gamete generation (GO:0043046)	8.65253260
4	protein-chromophore linkage (GO:0018298)	8.62469973
5	regulation of meiosis I (GO:0060631)	7.83172418
6	lipopolysaccharide metabolic process (GO:0008653)	7.80159314
7	regulation of pigment cell differentiation (GO:0050932)	7.49409908
8	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	7.37347022
9	sulfate transmembrane transport (GO:1902358)	7.32299218
10	regulation of protein glycosylation (GO:0060049)	7.28586643
11	positive regulation of developmental pigmentation (GO:0048087)	7.22592677
12	negative regulation of glycoprotein biosynthetic process (GO:0010561)	7.18235761
13	paraxial mesoderm development (GO:0048339)	6.60815774
14	negative regulation of cell cycle G2/M phase transition (GO:1902750)	6.59676823
15	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	6.48670938
16	sulfate transport (GO:0008272)	6.36931616
17	piRNA metabolic process (GO:0034587)	6.13048716
18	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	6.03439743
19	L-phenylalanine catabolic process (GO:0006559)	6.03439743
20	ribonucleoprotein complex disassembly (GO:0032988)	5.61350366
21	vitamin transmembrane transport (GO:0035461)	5.59836205
22	negative regulation of glycoprotein metabolic process (GO:1903019)	5.59122077
23	SMAD protein complex assembly (GO:0007183)	5.33439841
24	tyrosine metabolic process (GO:0006570)	5.26707609
25	notochord development (GO:0030903)	5.17507251
26	L-phenylalanine metabolic process (GO:0006558)	5.14360193
27	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.14360193
28	heme transport (GO:0015886)	5.02014376
29	meiotic chromosome segregation (GO:0045132)	4.87037950
30	nodal signaling pathway (GO:0038092)	4.62768039
31	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.55511290
32	positive regulation of meiosis (GO:0045836)	4.46532767
33	organelle disassembly (GO:1903008)	4.46266886
34	regulation of transforming growth factor beta2 production (GO:0032909)	4.45297764
35	serotonin receptor signaling pathway (GO:0007210)	4.42187462
36	centriole replication (GO:0007099)	4.28847228
37	regulation of odontogenesis (GO:0042481)	4.21480128
38	regulation of nuclear cell cycle DNA replication (GO:0033262)	4.19766742
39	negative regulation of stem cell proliferation (GO:2000647)	4.15065566
40	positive regulation of meiotic cell cycle (GO:0051446)	4.13664817
41	regulation of interleukin-5 production (GO:0032674)	4.11781593
42	protein retention in ER lumen (GO:0006621)	4.00751553
43	sulfur compound transport (GO:0072348)	4.00555916
44	germinal center formation (GO:0002467)	3.99460203
45	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.99287839
46	glycerol metabolic process (GO:0006071)	3.93781166
47	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.90908499
48	response to mercury ion (GO:0046689)	3.90332453
49	cellular response to gamma radiation (GO:0071480)	3.89133192
50	toxin metabolic process (GO:0009404)	3.84740327
51	regulation of developmental pigmentation (GO:0048070)	3.81165404
52	embryonic process involved in female pregnancy (GO:0060136)	3.73920317
53	aromatic amino acid family catabolic process (GO:0009074)	3.67053163
54	DNA damage induced protein phosphorylation (GO:0006975)	3.65454923
55	tachykinin receptor signaling pathway (GO:0007217)	3.57484783
56	iron coordination entity transport (GO:1901678)	3.55726365
57	rhodopsin mediated signaling pathway (GO:0016056)	3.54955564
58	heart valve formation (GO:0003188)	3.53605218
59	flavonoid metabolic process (GO:0009812)	3.52826098
60	alditol metabolic process (GO:0019400)	3.51089269
61	positive regulation of SMAD protein import into nucleus (GO:0060391)	3.50105761
62	negative regulation of cell-matrix adhesion (GO:0001953)	3.49835535
63	pantothenate metabolic process (GO:0015939)	3.49128054
64	aspartate family amino acid catabolic process (GO:0009068)	3.42802237
65	sympathetic nervous system development (GO:0048485)	3.40794055
66	lysine catabolic process (GO:0006554)	3.38338741
67	lysine metabolic process (GO:0006553)	3.38338741
68	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.37163045
69	response to epinephrine (GO:0071871)	3.35872706
70	negative regulation of neural precursor cell proliferation (GO:2000178)	3.35237405
71	inflammatory response to antigenic stimulus (GO:0002437)	3.28678591
72	somite rostral/caudal axis specification (GO:0032525)	3.13961389
73	uterus development (GO:0060065)	3.12157339
74	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	3.10807268
75	aromatic amino acid family metabolic process (GO:0009072)	3.06978741
76	urate metabolic process (GO:0046415)	3.02175488
77	DNA methylation (GO:0006306)	2.98732341
78	DNA alkylation (GO:0006305)	2.98732341
79	regulation of keratinocyte proliferation (GO:0010837)	2.95957398
80	polyol biosynthetic process (GO:0046173)	2.94319205
81	regulation of hair follicle development (GO:0051797)	2.93567043
82	positive regulation of fatty acid oxidation (GO:0046321)	2.91120863
83	negative regulation of BMP signaling pathway (GO:0030514)	2.84366287
84	2-oxoglutarate metabolic process (GO:0006103)	2.81592950
85	membrane lipid biosynthetic process (GO:0046467)	2.80925693
86	biotin metabolic process (GO:0006768)	2.80032580
87	protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)	2.79625773
88	organ induction (GO:0001759)	2.78795343
89	centriole assembly (GO:0098534)	2.77398886
90	cofactor transport (GO:0051181)	2.73283688
91	DNA deamination (GO:0045006)	2.71873215
92	sphingolipid biosynthetic process (GO:0030148)	2.71847512
93	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	2.69527777
94	regulation of translational termination (GO:0006449)	2.67625716
95	regulation of SMAD protein import into nucleus (GO:0060390)	2.67621123
96	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.67595342
97	adaptation of signaling pathway (GO:0023058)	2.63841474
98	sphingosine metabolic process (GO:0006670)	17.0948094
99	diol metabolic process (GO:0034311)	15.5098578
100	sphingoid metabolic process (GO:0046519)	13.8012289

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	AR_21572438_ChIP-Seq_LNCaP_Human	5.12087264
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.75218853
3	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	3.23145496
4	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.14226051
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.89736541
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.83105865
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.58120563
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.48342020
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.40453028
10	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.32174713
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.22808210
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.21466273
13	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.19286106
14	P300_19829295_ChIP-Seq_ESCs_Human	2.13861019
15	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.95510441
16	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.95510441
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.93348863
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.92771368
19	SOX2_19829295_ChIP-Seq_ESCs_Human	1.92536046
20	NANOG_19829295_ChIP-Seq_ESCs_Human	1.92536046
21	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.82084681
22	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.80983287
23	HOXB7_26014856_ChIP-Seq_BT474_Human	1.79202427
24	EGR1_19032775_ChIP-ChIP_M12_Human	1.76965627
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.70992576
26	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.68648662
27	STAT1_20625510_ChIP-Seq_HELA_Human	1.67436858
28	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.64470724
29	TCF4_23295773_ChIP-Seq_U87_Human	1.59616959
30	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.59292381
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51756281
32	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.49119303
33	OCT4_20526341_ChIP-Seq_ESCs_Human	1.48755395
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48689401
35	STAT3_23295773_ChIP-Seq_U87_Human	1.48650257
36	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.48321633
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.45015234
38	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.43795219
39	AR_25329375_ChIP-Seq_VCAP_Human	1.42428222
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.42040863
41	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.38409682
42	VDR_22108803_ChIP-Seq_LS180_Human	1.37439174
43	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.35731759
44	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.35596985
45	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.34113608
46	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.32398940
47	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.28424322
48	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.27622127
49	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.25137673
50	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.24286202
51	AR_19668381_ChIP-Seq_PC3_Human	1.22750284
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21716809
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21716809
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21156566
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.20712347
56	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.18151735
57	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.16642782
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.16624708
59	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.15727635
60	NCOR_22424771_ChIP-Seq_293T_Human	1.14424136
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.13061278
62	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.12960119
63	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.12726213
64	CEBPB_22108803_ChIP-Seq_LS180_Human	1.12355812
65	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.12261331
66	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11687299
67	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11520116
68	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.11475615
69	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.08909145
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.08554163
71	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.07638200
72	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.07541370
73	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07525641
74	SMAD4_21799915_ChIP-Seq_A2780_Human	1.07426876
75	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.05576747
76	STAT1_17558387_ChIP-Seq_HELA_Human	1.05495993
77	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.04341419
78	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.04263563
79	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.04155806
80	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.03781794
81	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03590106
82	SPI1_20517297_ChIP-Seq_HL60_Human	1.03035034
83	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.03030153
84	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.01887554
85	CDX2_22108803_ChIP-Seq_LS180_Human	1.01661588
86	MYC_19829295_ChIP-Seq_ESCs_Human	1.01409964
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00782457
88	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.00378142
89	TP53_16413492_ChIP-PET_HCT116_Human	0.99942715
90	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.99741921
91	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99449821
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98852289
93	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.97712305
94	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.97647872
95	P53_21459846_ChIP-Seq_SAOS-2_Human	0.96615873
96	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.96176357
97	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.95931655
98	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.95802377
99	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95693984
100	SCL_19346495_ChIP-Seq_HPC-7_Human	0.94670060

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	9.36836418
2	MP0003136_yellow_coat_color	8.17686316
3	MP0005171_absent_coat_pigmentation	7.21107472
4	MP0002653_abnormal_ependyma_morphology	6.01231228
5	MP0003045_fibrosis	4.31938008
6	MP0003890_abnormal_embryonic-extraembry	4.31021331
7	MP0003646_muscle_fatigue	4.14242536
8	MP0000569_abnormal_digit_pigmentation	3.46550460
9	MP0003879_abnormal_hair_cell	3.38663847
10	MP0004381_abnormal_hair_follicle	3.01678150
11	MP0005670_abnormal_white_adipose	2.38226382
12	MP0004147_increased_porphyrin_level	2.32814548
13	MP0002138_abnormal_hepatobiliary_system	2.25574409
14	MP0003195_calcinosis	2.20337066
15	MP0005085_abnormal_gallbladder_physiolo	2.18409147
16	MP0005075_abnormal_melanosome_morpholog	2.08494416
17	MP0003705_abnormal_hypodermis_morpholog	1.93027847
18	MP0000749_muscle_degeneration	1.89101200
19	MP0002168_other_aberrant_phenotype	1.88178483
20	MP0002938_white_spotting	1.78175227
21	MP0005365_abnormal_bile_salt	1.58597247
22	MP0010352_gastrointestinal_tract_polyps	1.43107979
23	MP0002095_abnormal_skin_pigmentation	1.37317369
24	MP0002075_abnormal_coat/hair_pigmentati	1.30502839
25	MP0004233_abnormal_muscle_weight	1.28837117
26	MP0005174_abnormal_tail_pigmentation	1.19196439
27	MP0002160_abnormal_reproductive_system	1.16583570
28	MP0006054_spinal_hemorrhage	1.13150838
29	MP0005395_other_phenotype	1.08134231
30	MP0003137_abnormal_impulse_conducting	0.96101070
31	MP0001186_pigmentation_phenotype	0.94990123
32	MP0001501_abnormal_sleep_pattern	0.94978898
33	MP0004043_abnormal_pH_regulation	0.86836144
34	MP0002735_abnormal_chemical_nociception	0.86330737
35	MP0000015_abnormal_ear_pigmentation	0.83447988
36	MP0005330_cardiomyopathy	0.82235070
37	MP0002876_abnormal_thyroid_physiology	0.78948307
38	MP0002269_muscular_atrophy	0.78051823
39	MP0000427_abnormal_hair_cycle	0.77689992
40	MP0005377_hearing/vestibular/ear_phenot	0.72713653
41	MP0003878_abnormal_ear_physiology	0.72713653
42	MP0003252_abnormal_bile_duct	0.71702545
43	MP0001324_abnormal_eye_pigmentation	0.68090886
44	MP0003950_abnormal_plasma_membrane	0.64798748
45	MP0005319_abnormal_enzyme/_coenzyme	0.62382302
46	MP0008875_abnormal_xenobiotic_pharmacok	0.61096612
47	MP0008770_decreased_survivor_rate	0.60121743
48	MP0002332_abnormal_exercise_endurance	0.59209024
49	MP0000534_abnormal_ureter_morphology	0.58702088
50	MP0001486_abnormal_startle_reflex	0.58468721
51	MP0002396_abnormal_hematopoietic_system	0.57716985
52	MP0002272_abnormal_nervous_system	0.57595674
53	MP0001984_abnormal_olfaction	0.55153511
54	MP0003300_gastrointestinal_ulcer	0.52590831
55	MP0009745_abnormal_behavioral_response	0.52458136
56	MP0002102_abnormal_ear_morphology	0.51555474
57	MP0009764_decreased_sensitivity_to	0.50836303
58	MP0002928_abnormal_bile_duct	0.48137843
59	MP0005389_reproductive_system_phenotype	0.47817587
60	MP0001970_abnormal_pain_threshold	0.46030735
61	MP0001661_extended_life_span	0.45283869
62	MP0005076_abnormal_cell_differentiation	0.44541162
63	MP0004130_abnormal_muscle_cell	0.44439576
64	MP0008569_lethality_at_weaning	0.43379549
65	MP0002254_reproductive_system_inflammat	0.41715934
66	MP0009046_muscle_twitch	0.41297877
67	MP0002277_abnormal_respiratory_mucosa	0.39106174
68	MP0005551_abnormal_eye_electrophysiolog	0.38690785
69	MP0002971_abnormal_brown_adipose	0.38166764
70	MP0004142_abnormal_muscle_tone	0.37755928
71	MP0002064_seizures	0.37343212
72	MP0002229_neurodegeneration	0.34891785
73	MP0005410_abnormal_fertilization	0.34814536
74	MP0003937_abnormal_limbs/digits/tail_de	0.33662140
75	MP0005266_abnormal_metabolism	0.33038631
76	MP0002572_abnormal_emotion/affect_behav	0.32485935
77	MP0009115_abnormal_fat_cell	0.32399580
78	MP0008874_decreased_physiological_sensi	0.32180437
79	MP0002733_abnormal_thermal_nociception	0.31722705
80	MP0008872_abnormal_physiological_respon	0.31645315
81	MP0001800_abnormal_humoral_immune	0.30802879
82	MP0004484_altered_response_of	0.29166484
83	MP0000026_abnormal_inner_ear	0.29129123
84	MP0002106_abnormal_muscle_physiology	0.26318652
85	MP0001986_abnormal_taste_sensitivity	0.24817012
86	MP0005646_abnormal_pituitary_gland	0.24633417
87	MP0002751_abnormal_autonomic_nervous	0.24337313
88	MP0001963_abnormal_hearing_physiology	0.23906899
89	MP0000470_abnormal_stomach_morphology	0.23771549
90	MP0005387_immune_system_phenotype	0.23284997
91	MP0001790_abnormal_immune_system	0.23284997
92	MP0005620_abnormal_muscle_contractility	0.23101442
93	MP0000230_abnormal_systemic_arterial	0.22732225
94	MP0000377_abnormal_hair_follicle	0.21830996
95	MP0003635_abnormal_synaptic_transmissio	0.21206700
96	MP0005448_abnormal_energy_balance	0.20587241
97	MP0003959_abnormal_lean_body	0.20120721
98	MP0005535_abnormal_body_temperature	0.19875073
99	MP0000367_abnormal_coat/_hair	0.19443066
100	MP0004742_abnormal_vestibular_system	0.19415845

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	9.46887953
2	Acanthocytosis (HP:0001927)	7.77158581
3	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	7.51388061
4	Parakeratosis (HP:0001036)	7.02532579
5	Aplastic anemia (HP:0001915)	5.85899155
6	Dialeptic seizures (HP:0011146)	5.01101426
7	Rectal prolapse (HP:0002035)	4.47176726
8	Proximal amyotrophy (HP:0007126)	4.40367758
9	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.31565721
10	Colon cancer (HP:0003003)	4.31041820
11	Hematochezia (HP:0002573)	4.29892594
12	Congenital ichthyosiform erythroderma (HP:0007431)	4.17496549
13	Spontaneous hematomas (HP:0007420)	4.16446575
14	Aplasia/Hypoplasia of the uvula (HP:0010293)	4.13754489
15	Focal seizures (HP:0007359)	3.98191509
16	Vertebral arch anomaly (HP:0008438)	3.84301785
17	Pancreatic cysts (HP:0001737)	3.77939817
18	Scapular winging (HP:0003691)	3.73764325
19	Difficulty walking (HP:0002355)	3.72053339
20	Erythroderma (HP:0001019)	3.62379562
21	Poikilocytosis (HP:0004447)	3.49526454
22	Conjunctival telangiectasia (HP:0000524)	3.38217858
23	Potter facies (HP:0002009)	3.35373927
24	Facial shape deformation (HP:0011334)	3.35373927
25	Bilateral sensorineural hearing impairment (HP:0008619)	3.25151875
26	Esophageal varix (HP:0002040)	3.21504905
27	Ulnar claw (HP:0001178)	3.12962154
28	Abnormality of the renal cortex (HP:0011035)	3.08827692
29	Radial bowing (HP:0002986)	3.06102184
30	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.02418771
31	Hypoplastic iliac wings (HP:0002866)	3.00850879
32	Ulnar bowing (HP:0003031)	2.87627804
33	Overlapping toe (HP:0001845)	2.82972896
34	Cerebellar dysplasia (HP:0007033)	2.82097929
35	Enlarged kidneys (HP:0000105)	2.70708859
36	Inability to walk (HP:0002540)	2.65122662
37	Abnormality of the vocal cords (HP:0008777)	2.64673284
38	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.64000599
39	Broad ribs (HP:0000885)	2.61735750
40	Abnormality of the renal medulla (HP:0100957)	2.57977556
41	IgM deficiency (HP:0002850)	2.55315737
42	Portal hypertension (HP:0001409)	2.54546707
43	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.54427914
44	Petechiae (HP:0000967)	2.51045034
45	Pendular nystagmus (HP:0012043)	2.50284987
46	Tubular atrophy (HP:0000092)	2.45990936
47	Synostosis of carpal bones (HP:0005048)	2.44018308
48	Progressive inability to walk (HP:0002505)	2.41855276
49	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.37480054
50	Gangrene (HP:0100758)	2.36730125
51	Abnormality of the hepatic vasculature (HP:0006707)	2.33677981
52	Nephronophthisis (HP:0000090)	2.31222748
53	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.28655444
54	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.19427531
55	Hypokalemia (HP:0002900)	2.18306336
56	Peripheral hypomyelination (HP:0007182)	2.17990995
57	Abnormality of macular pigmentation (HP:0008002)	2.17917959
58	Type II lissencephaly (HP:0007260)	2.15751779
59	Hypoalbuminemia (HP:0003073)	2.14061294
60	Abnormal albumin level (HP:0012116)	2.14061294
61	Autoimmune hemolytic anemia (HP:0001890)	2.12383496
62	Lack of skin elasticity (HP:0100679)	2.11948875
63	Abnormality of the shoulder girdle musculature (HP:0001435)	2.10692249
64	Thickened calvaria (HP:0002684)	2.10060761
65	Severe visual impairment (HP:0001141)	2.09657038
66	Chromsome breakage (HP:0040012)	2.09502743
67	Tarsal synostosis (HP:0008368)	2.08344254
68	Decreased circulating renin level (HP:0003351)	2.07923725
69	Opisthotonus (HP:0002179)	2.07274695
70	Colitis (HP:0002583)	2.05630714
71	Albinism (HP:0001022)	2.00285298
72	Amelogenesis imperfecta (HP:0000705)	10.0272091
73	Abnormality of potassium homeostasis (HP:0011042)	1.98555612
74	Chronic diarrhea (HP:0002028)	1.97461530
75	Abnormality of the wing of the ilium (HP:0011867)	1.93506240
76	Dehydration (HP:0001944)	1.93331296
77	Cystic liver disease (HP:0006706)	1.92274572
78	Synostosis involving bones of the feet (HP:0009140)	1.87539386
79	Synostosis involving bones of the lower limbs (HP:0009138)	1.87539386
80	Tubulointerstitial fibrosis (HP:0005576)	1.86030350
81	Neoplasm of the small intestine (HP:0100833)	1.82255590
82	Increased cerebral lipofuscin (HP:0011813)	1.81353130
83	Retinitis pigmentosa (HP:0000510)	1.78564474
84	Bowed forearm bones (HP:0003956)	1.78017352
85	Bowing of the arm (HP:0006488)	1.78017352
86	Purpura (HP:0000979)	1.77727360
87	Recurrent sinusitis (HP:0011108)	1.76949539
88	Palmoplantar keratoderma (HP:0000982)	1.74583216
89	Clumsiness (HP:0002312)	1.72269822
90	Type I transferrin isoform profile (HP:0003642)	1.71198496
91	Posterior embryotoxon (HP:0000627)	1.70518525
92	Aortic valve stenosis (HP:0001650)	1.65800288
93	Abnormality of the line of Schwalbe (HP:0008048)	1.65604624
94	Visceral angiomatosis (HP:0100761)	1.65550306
95	Hemangiomatosis (HP:0007461)	1.64206349
96	Absence seizures (HP:0002121)	1.61693715
97	Gastrointestinal stroma tumor (HP:0100723)	1.61462604
98	Neonatal respiratory distress (HP:0002643)	1.60036061
99	Macular degeneration (HP:0000608)	1.59710744
100	Neoplasm of the colon (HP:0100273)	1.57236323

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK38L	7.25504709
2	LATS2	6.69770024
3	PRKD3	2.99363456
4	ACVR1B	2.76593920
5	STK38	2.76401128
6	ZAK	2.75821640
7	FRK	2.40934087
8	NLK	2.27646407
9	MAP2K2	2.27603585
10	STK3	2.25433613
11	LATS1	10.6806607
12	MELK	1.82249559
13	BMPR1B	1.62604759
14	PIK3CG	1.59211924
15	GRK7	1.16543625
16	NEK2	1.06589465
17	KSR2	1.03860075
18	MAP3K2	1.03385848
19	EIF2AK3	1.02630199
20	PDPK1	1.00959727
21	MOS	0.94085813
22	PRKAA2	0.93405293
23	TAF1	0.91556854
24	ADRBK2	0.91401276
25	IRAK3	0.91296593
26	TGFBR1	0.87286054
27	PINK1	0.84121182
28	TGFBR2	0.83763956
29	WNK4	0.77242687
30	DAPK2	0.71668895
31	CSNK1A1L	0.69681208
32	ADRBK1	0.69169234
33	PRKD1	0.61608824
34	GRK5	0.52662830
35	NEK9	0.49483676
36	STK10	0.47887108
37	STK11	0.45610637
38	TNK2	0.44525734
39	MAP2K1	0.38245447
40	TAOK3	0.35394547
41	PIM1	0.34568518
42	TTK	0.32563600
43	OXSR1	0.32016513
44	NME1	0.24605503
45	EIF2AK2	0.23747578
46	TXK	0.23478320
47	CDK19	0.22193665
48	PRKCI	0.18977731
49	AKT2	0.17839273
50	TEC	0.17186146
51	CSNK1D	0.16713577
52	STK39	0.16280388
53	ITK	0.14807212
54	PLK1	0.14603274
55	MAPK3	0.13498179
56	CHEK2	0.11287217
57	ABL1	0.11102165
58	IRAK4	0.10149063
59	GRK1	0.07661637
60	JAK2	0.06616366
61	PRKACA	0.05705754
62	MAPK1	0.04433019
63	PIK3CA	0.04290680
64	PDK1	0.04067281
65	FER	0.03811802
66	NEK1	0.03627773
67	CSF1R	0.03598462
68	PRKG2	0.03372444
69	PLK2	0.03033324
70	PRKCE	0.02310455
71	CDK3	0.02095610
72	RET	0.02073975
73	CAMK2A	0.01780465
74	MAP2K6	0.00451038
75	MAP3K7	0.00441784
76	MAP3K1	0.00064543
77	IGF1R	-0.0918120
78	NTRK3	-0.0907370
79	PRKCG	-0.0884182
80	EPHA4	-0.0856864
81	PTK2B	-0.0807799
82	GSK3B	-0.0805231
83	MAP4K1	-0.0771062
84	PLK3	-0.0740241
85	MAP3K8	-0.0722367
86	INSRR	-0.0678203
87	MAPKAPK5	-0.0635962
88	PAK1	-0.0590485
89	KIT	-0.0584450
90	IKBKB	-0.0495180
91	CSNK1A1	-0.0464861
92	CAMK2B	-0.0449708
93	MAPK7	-0.0301058
94	BTK	-0.0273222
95	CDK5	-0.0260168
96	AKT1	-0.0259749
97	WNK3	-0.0211126
98	PRKACB	-0.0179110
99	MAPK8	-0.0023495
100	NEK6	-0.0015002

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	8.59969570
2	Phototransduction_Homo sapiens_hsa04744	4.25317497
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.84691430
4	Sphingolipid metabolism_Homo sapiens_hsa00600	3.80812714
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.52688798
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.87090215
7	Nicotine addiction_Homo sapiens_hsa05033	2.76613295
8	Taste transduction_Homo sapiens_hsa04742	2.18977968
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.12591801
10	Phenylalanine metabolism_Homo sapiens_hsa00360	1.99498117
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.93804519
12	Morphine addiction_Homo sapiens_hsa05032	1.72090209
13	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.68146428
14	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.67282314
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.51101270
16	Histidine metabolism_Homo sapiens_hsa00340	1.50790067
17	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.49295135
18	Viral myocarditis_Homo sapiens_hsa05416	1.48461855
19	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.41571808
20	GABAergic synapse_Homo sapiens_hsa04727	1.27438898
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.22832896
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.19697440
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.19326158
24	Asthma_Homo sapiens_hsa05310	1.17347991
25	Butanoate metabolism_Homo sapiens_hsa00650	1.15348258
26	One carbon pool by folate_Homo sapiens_hsa00670	1.14477340
27	ABC transporters_Homo sapiens_hsa02010	1.07796155
28	Calcium signaling pathway_Homo sapiens_hsa04020	1.06495251
29	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.05170275
30	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.03957632
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.01635508
32	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.97935541
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.97913298
34	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.96799130
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90173356
36	VEGF signaling pathway_Homo sapiens_hsa04370	0.87792660
37	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.84128430
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83711422
39	Basal transcription factors_Homo sapiens_hsa03022	0.81404075
40	Tyrosine metabolism_Homo sapiens_hsa00350	0.79919048
41	Serotonergic synapse_Homo sapiens_hsa04726	0.75406331
42	Glutamatergic synapse_Homo sapiens_hsa04724	0.70481258
43	Bile secretion_Homo sapiens_hsa04976	0.68839766
44	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.68805303
45	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.67283761
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.61381067
47	Linoleic acid metabolism_Homo sapiens_hsa00591	0.61211385
48	Tuberculosis_Homo sapiens_hsa05152	0.58041948
49	cAMP signaling pathway_Homo sapiens_hsa04024	0.53614367
50	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51846795
51	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.51193698
52	Homologous recombination_Homo sapiens_hsa03440	0.51088071
53	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50510706
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49656552
55	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.47809761
56	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.46312033
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46021204
58	ECM-receptor interaction_Homo sapiens_hsa04512	0.45579386
59	Salivary secretion_Homo sapiens_hsa04970	0.45169627
60	Fatty acid degradation_Homo sapiens_hsa00071	0.45100347
61	Olfactory transduction_Homo sapiens_hsa04740	0.42119274
62	Colorectal cancer_Homo sapiens_hsa05210	0.41889053
63	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.41239526
64	Pyruvate metabolism_Homo sapiens_hsa00620	0.40532592
65	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.40434776
66	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.40130643
67	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.37546426
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.37476457
69	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.37286412
70	Lysine degradation_Homo sapiens_hsa00310	0.36906361
71	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.35366609
72	Selenocompound metabolism_Homo sapiens_hsa00450	0.35356439
73	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.35127203
74	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.34905864
75	Adherens junction_Homo sapiens_hsa04520	0.34844138
76	Fanconi anemia pathway_Homo sapiens_hsa03460	0.34763982
77	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.34169598
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.34107139
79	Hippo signaling pathway_Homo sapiens_hsa04390	0.32825529
80	Graft-versus-host disease_Homo sapiens_hsa05332	0.32576204
81	African trypanosomiasis_Homo sapiens_hsa05143	0.30889800
82	Sulfur relay system_Homo sapiens_hsa04122	0.29715452
83	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.27705388
84	Thyroid cancer_Homo sapiens_hsa05216	0.27122038
85	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.26450646
86	Arginine and proline metabolism_Homo sapiens_hsa00330	0.25616295
87	Gastric acid secretion_Homo sapiens_hsa04971	0.25213066
88	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.24260714
89	Circadian entrainment_Homo sapiens_hsa04713	0.23632762
90	Retinol metabolism_Homo sapiens_hsa00830	0.22856343
91	Insulin secretion_Homo sapiens_hsa04911	0.19360529
92	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.18772622
93	Platelet activation_Homo sapiens_hsa04611	0.18121223
94	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.16502619
95	Metabolic pathways_Homo sapiens_hsa01100	0.14002198
96	Allograft rejection_Homo sapiens_hsa05330	0.13767079
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.13569419
98	Ether lipid metabolism_Homo sapiens_hsa00565	0.13290835
99	Peroxisome_Homo sapiens_hsa04146	0.13201971
100	Chemical carcinogenesis_Homo sapiens_hsa05204	0.11876196

CKBP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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