CKLF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)4.69314391
2cytidine catabolic process (GO:0006216)4.69314391
3cytidine deamination (GO:0009972)4.69314391
4ribosomal small subunit assembly (GO:0000028)4.68438498
5neutrophil activation involved in immune response (GO:0002283)4.10041785
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.98484467
7pyrimidine ribonucleoside catabolic process (GO:0046133)3.98258245
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88866842
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.81155266
10viral transcription (GO:0019083)3.77220922
11ribosomal small subunit biogenesis (GO:0042274)3.75928152
12antigen processing and presentation of endogenous antigen (GO:0019883)3.68587908
13DNA deamination (GO:0045006)3.66564004
14ATP synthesis coupled proton transport (GO:0015986)3.64298927
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.64298927
16negative regulation of cell killing (GO:0031342)3.61213075
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.61213075
18translational termination (GO:0006415)3.59081357
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57881735
20response to interferon-beta (GO:0035456)3.54852136
21positive regulation of interleukin-8 secretion (GO:2000484)3.46160674
22cellular response to interleukin-15 (GO:0071350)3.45911292
23regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.45188830
24mast cell activation (GO:0045576)3.45168455
25response to peptidoglycan (GO:0032494)3.43452001
26respiratory burst (GO:0045730)3.42830153
27cellular response to interferon-beta (GO:0035458)3.37431293
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.32590639
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.28775851
30defense response to protozoan (GO:0042832)3.27801813
31positive regulation of T cell mediated cytotoxicity (GO:0001916)3.27630823
32immunoglobulin mediated immune response (GO:0016064)3.26699658
33leukocyte aggregation (GO:0070486)3.23328531
34cotranslational protein targeting to membrane (GO:0006613)3.22469672
35protein targeting to ER (GO:0045047)3.19505206
36regulation of regulatory T cell differentiation (GO:0045589)3.18971476
37mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14069888
38respiratory electron transport chain (GO:0022904)3.12562539
39regulation of B cell receptor signaling pathway (GO:0050855)3.09743110
40regulation of T cell mediated cytotoxicity (GO:0001914)3.07763705
41electron transport chain (GO:0022900)3.06364597
42telomere maintenance via semi-conservative replication (GO:0032201)3.05898807
43response to protozoan (GO:0001562)3.03898085
44protein localization to endoplasmic reticulum (GO:0070972)3.02474500
45negative T cell selection (GO:0043383)3.02119418
46actin nucleation (GO:0045010)3.00938684
47establishment of protein localization to endoplasmic reticulum (GO:0072599)2.99919123
48translational elongation (GO:0006414)2.99673895
49response to interleukin-15 (GO:0070672)2.96644241
50regulation of interleukin-8 secretion (GO:2000482)2.96307875
51maturation of SSU-rRNA (GO:0030490)2.90739788
52DNA strand elongation involved in DNA replication (GO:0006271)2.86811383
53positive thymic T cell selection (GO:0045059)2.86140749
54neutrophil activation (GO:0042119)2.85931428
55positive regulation of gamma-delta T cell activation (GO:0046645)2.85596985
56positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84570702
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84340896
58telomere maintenance via recombination (GO:0000722)2.83911688
59viral life cycle (GO:0019058)2.83585742
60type I interferon signaling pathway (GO:0060337)2.82806441
61cellular response to type I interferon (GO:0071357)2.82806441
62negative regulation of T cell apoptotic process (GO:0070233)2.81598725
63antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.81496389
64response to type I interferon (GO:0034340)2.80346593
65regulation of cellular amino acid metabolic process (GO:0006521)2.79305703
66cellular extravasation (GO:0045123)2.79054902
67negative thymic T cell selection (GO:0045060)2.78485040
68positive regulation of defense response to virus by host (GO:0002230)2.78074598
69DNA strand elongation (GO:0022616)2.76639139
70protein complex biogenesis (GO:0070271)2.75562232
71negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75133543
72antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.74322879
73intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74050201
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74050201
75signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.73526960
76signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.73526960
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.73526960
78positive regulation of antigen processing and presentation (GO:0002579)2.72955606
79antigen processing and presentation via MHC class Ib (GO:0002475)2.70130368
80cellular defense response (GO:0006968)2.69665757
81nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.69458263
82myeloid dendritic cell activation (GO:0001773)2.69255742
83detection of other organism (GO:0098543)2.68531612
84positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.68454416
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.67880274
86T cell migration (GO:0072678)2.67721432
87cellular protein complex disassembly (GO:0043624)2.67172157
88regulation of gamma-delta T cell differentiation (GO:0045586)2.66631551
89B cell mediated immunity (GO:0019724)2.66574065
90cellular response to zinc ion (GO:0071294)2.65758331
91granulocyte activation (GO:0036230)2.65491674
92CENP-A containing nucleosome assembly (GO:0034080)2.64809044
93myeloid cell activation involved in immune response (GO:0002275)2.64222803
94regulation of leukocyte mediated cytotoxicity (GO:0001910)2.64150775
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.62858275
96ribosomal large subunit biogenesis (GO:0042273)2.62502111
97regulation of antigen processing and presentation (GO:0002577)2.62306500
98production of molecular mediator involved in inflammatory response (GO:0002532)2.59801432
99regulation of activation of Janus kinase activity (GO:0010533)2.59577250
100positive regulation of monocyte chemotaxis (GO:0090026)2.59440091
101leukocyte mediated cytotoxicity (GO:0001909)2.59316082
102signal transduction involved in DNA damage checkpoint (GO:0072422)2.59068588
103signal transduction involved in DNA integrity checkpoint (GO:0072401)2.59068588
104mast cell activation involved in immune response (GO:0002279)2.58661020
105mast cell degranulation (GO:0043303)2.58661020
106proteasome assembly (GO:0043248)2.58479419
107regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.57618650
108negative regulation of lymphocyte apoptotic process (GO:0070229)2.57102295
109purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.57096968
110regulation of T cell tolerance induction (GO:0002664)2.57073053
111positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.56916794
112regulation of gamma-delta T cell activation (GO:0046643)2.56642233
113translational initiation (GO:0006413)2.56518603
114negative regulation of interleukin-12 production (GO:0032695)2.56452826
115Arp2/3 complex-mediated actin nucleation (GO:0034314)2.55144834
116platelet dense granule organization (GO:0060155)2.54278179
117positive regulation by symbiont of host defense response (GO:0052509)2.52692650
118modulation by symbiont of host defense response (GO:0052031)2.52692650
119modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.52692650
120modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.52692650
121positive regulation by organism of defense response of other organism involved in symbiotic interact2.52692650
122modulation by symbiont of host immune response (GO:0052553)2.52692650
123purine deoxyribonucleotide catabolic process (GO:0009155)2.52556175
124natural killer cell mediated cytotoxicity (GO:0042267)2.52446458
125natural killer cell mediated immunity (GO:0002228)2.52446458
126signal transduction involved in cell cycle checkpoint (GO:0072395)2.51934912
127deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.50889472
128response to interferon-alpha (GO:0035455)2.50879608
129kinetochore organization (GO:0051383)2.50734112
130interferon-gamma-mediated signaling pathway (GO:0060333)2.50352647
131negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.48468521
132negative regulation of ligase activity (GO:0051352)2.48468521
133protein neddylation (GO:0045116)2.48132983
134leukocyte degranulation (GO:0043299)2.47758151
135pyrimidine nucleoside catabolic process (GO:0046135)2.47315180
136mitotic recombination (GO:0006312)2.47003924
137mitochondrial respiratory chain complex assembly (GO:0033108)2.46090164
138cellular response to exogenous dsRNA (GO:0071360)2.45956233
139positive regulation of alpha-beta T cell proliferation (GO:0046641)2.45500433
140positive regulation of interferon-alpha production (GO:0032727)2.45484246
141chromatin remodeling at centromere (GO:0031055)2.44514964
142cytochrome complex assembly (GO:0017004)2.43713562
143purine nucleotide salvage (GO:0032261)2.43079845
144superoxide anion generation (GO:0042554)2.41471740
145regulation of chemokine biosynthetic process (GO:0045073)2.40624798
146regulation of mast cell activation (GO:0033003)2.39531605
147interferon-gamma production (GO:0032609)2.38766183
148regulation of B cell differentiation (GO:0045577)2.38686056
149negative regulation of viral genome replication (GO:0045071)2.37918483
150regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.37683110
151regulation of alpha-beta T cell proliferation (GO:0046640)2.36505625
152positive regulation of B cell differentiation (GO:0045579)2.36077921
153regulation of interferon-alpha production (GO:0032647)2.35621429
154exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.34939939
155kinetochore assembly (GO:0051382)2.34457322
156positive regulation of mast cell activation (GO:0033005)2.34221074
157myeloid leukocyte activation (GO:0002274)2.32753994
158regulation of RIG-I signaling pathway (GO:0039535)2.32738167
159detection of bacterium (GO:0016045)2.32405448
160sequestering of actin monomers (GO:0042989)2.32295404
161regulation of T cell migration (GO:2000404)2.32255273
162positive regulation of T cell migration (GO:2000406)2.31481114
163positive regulation of chemokine biosynthetic process (GO:0045080)2.30033268
164negative regulation of myeloid cell apoptotic process (GO:0033033)2.29781715
165regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.29727493
166positive regulation of lymphocyte migration (GO:2000403)2.29482997

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.08665109
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.30230480
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.23520977
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.96522202
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.64749278
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.53566999
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.99476962
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.96386695
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.86870762
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.66852571
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.64563742
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60350968
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.59974414
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.57177480
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.52920314
16* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.51505032
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.37483005
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.34215238
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32029870
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.31906990
21SPI1_23547873_ChIP-Seq_NB4_Human2.30441163
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.26916398
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24422712
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22507335
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18493730
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.15351251
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11344906
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09482989
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03179883
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.02386516
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01960378
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98040659
33* VDR_23849224_ChIP-Seq_CD4+_Human1.96490024
34* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91226267
35* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89573113
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87810960
37* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87486590
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85241193
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78888041
40SCL_19346495_ChIP-Seq_HPC-7_Human1.77497086
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75612577
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75079477
43ELK1_19687146_ChIP-ChIP_HELA_Human1.74943152
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.74215601
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.72711484
46* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72561229
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.66009512
48* MYB_26560356_Chip-Seq_TH2_Human1.64852760
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63437306
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63283325
51FOXP3_21729870_ChIP-Seq_TREG_Human1.59964398
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59947215
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58941956
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54952339
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.54615376
56GATA3_27048872_Chip-Seq_THYMUS_Human1.54434563
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53191677
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52841827
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.51484854
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51048043
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.49270222
62* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44048713
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42960940
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41139205
65DCP1A_22483619_ChIP-Seq_HELA_Human1.41126825
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37186047
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33530317
68XRN2_22483619_ChIP-Seq_HELA_Human1.31985715
69* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28606396
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26369142
71* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26278133
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25769066
73MYB_26560356_Chip-Seq_TH1_Human1.25624632
74* TTF2_22483619_ChIP-Seq_HELA_Human1.24905955
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24580482
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23401313
77* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23108227
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22646150
79SPI1_23127762_ChIP-Seq_K562_Human1.22351443
80VDR_24763502_ChIP-Seq_THP-1_Human1.19745611
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18316807
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17431369
83MAF_26560356_Chip-Seq_TH1_Human1.17146195
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16356716
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.14300079
86* VDR_21846776_ChIP-Seq_THP-1_Human1.11760745
87RUNX_20019798_ChIP-Seq_JUKART_Human1.10409453
88MAF_26560356_Chip-Seq_TH2_Human1.09996120
89STAT1_20625510_ChIP-Seq_HELA_Human1.05667670
90PU_27001747_Chip-Seq_BMDM_Mouse1.05558594
91CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05302281
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05195404
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05122793
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04518814
95ELK1_22589737_ChIP-Seq_MCF10A_Human1.04295433
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04240180
97CIITA_25753668_ChIP-Seq_RAJI_Human1.02800539
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02739699
99BCL6_27268052_Chip-Seq_Bcells_Human1.02302731
100* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02090689
101YY1_21170310_ChIP-Seq_MESCs_Mouse1.01832400
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01776265
103EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00426249
104GABP_19822575_ChIP-Seq_HepG2_Human0.99963148
105* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99732773
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99523518
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98805386
108EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98296295
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97740638
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97608530
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96496018
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96106356
113TFEB_21752829_ChIP-Seq_HELA_Human0.96077554
114EGR1_19374776_ChIP-ChIP_THP-1_Human0.95433286
115PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93950063
116GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93256481
117UTX_26944678_Chip-Seq_JUKART_Human0.92651416
118* GATA3_26560356_Chip-Seq_TH2_Human0.91290330
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91282803
120ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89462626
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89248969
122PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87614421

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.40785547
2MP0009785_altered_susceptibility_to3.72581132
3MP0002148_abnormal_hypersensitivity_rea3.50082643
4MP0005671_abnormal_response_to3.43423221
5MP0003806_abnormal_nucleotide_metabolis3.31533116
6MP0003436_decreased_susceptibility_to3.21574051
7MP0005000_abnormal_immune_tolerance2.95472668
8MP0005025_abnormal_response_to2.80913268
9MP0003724_increased_susceptibility_to2.70921519
10MP0002419_abnormal_innate_immunity2.64557994
11MP0000685_abnormal_immune_system2.63366956
12MP0001800_abnormal_humoral_immune2.62586594
13MP0002452_abnormal_antigen_presenting2.55786578
14MP0002723_abnormal_immune_serum2.49151748
15MP0003763_abnormal_thymus_physiology2.39169791
16MP0002420_abnormal_adaptive_immunity2.39067818
17MP0001819_abnormal_immune_cell2.38765229
18MP0001853_heart_inflammation2.38230531
19MP0005387_immune_system_phenotype2.31854010
20MP0001790_abnormal_immune_system2.31854010
21MP0008057_abnormal_DNA_replication2.26831355
22MP0006082_CNS_inflammation2.26761405
23MP0002405_respiratory_system_inflammati2.17072251
24MP0002396_abnormal_hematopoietic_system2.15625440
25MP0002398_abnormal_bone_marrow2.08341653
26MP0009333_abnormal_splenocyte_physiolog2.07916124
27MP0003693_abnormal_embryo_hatching2.05007618
28MP0000716_abnormal_immune_system1.90345858
29MP0005464_abnormal_platelet_physiology1.84245599
30MP0010094_abnormal_chromosome_stability1.83259696
31MP0000689_abnormal_spleen_morphology1.72340665
32MP0002006_tumorigenesis1.72338174
33MP0002722_abnormal_immune_system1.67739597
34MP0002429_abnormal_blood_cell1.66745642
35MP0010155_abnormal_intestine_physiology1.63922411
36MP0008007_abnormal_cellular_replicative1.63212148
37MP0001845_abnormal_inflammatory_respons1.62466818
38MP0008058_abnormal_DNA_repair1.62331245
39MP0005174_abnormal_tail_pigmentation1.61858529
40MP0002166_altered_tumor_susceptibility1.60887845
41MP0004808_abnormal_hematopoietic_stem1.60287095
42MP0000490_abnormal_crypts_of1.53284067
43MP0005410_abnormal_fertilization1.52492698
44MP0001545_abnormal_hematopoietic_system1.51656589
45MP0005397_hematopoietic_system_phenotyp1.51656589
46MP0003077_abnormal_cell_cycle1.51608253
47MP0003186_abnormal_redox_activity1.51365548
48MP0000858_altered_metastatic_potential1.48932391
49MP0003191_abnormal_cellular_cholesterol1.48639934
50MP0001533_abnormal_skeleton_physiology1.48086688
51MP0005075_abnormal_melanosome_morpholog1.38956221
52MP0006036_abnormal_mitochondrial_physio1.37500336
53MP0009379_abnormal_foot_pigmentation1.35078664
54MP0000465_gastrointestinal_hemorrhage1.33926989
55MP0008469_abnormal_protein_level1.32682977
56MP0000343_altered_response_to1.32267885
57MP0000703_abnormal_thymus_morphology1.30356834
58MP0003448_altered_tumor_morphology1.29643725
59MP0003195_calcinosis1.29597753
60MP0002138_abnormal_hepatobiliary_system1.29098636
61MP0002132_abnormal_respiratory_system1.27321695
62MP0005084_abnormal_gallbladder_morpholo1.24845707
63MP0004947_skin_inflammation1.24255344
64MP0009764_decreased_sensitivity_to1.23668685
65MP0003111_abnormal_nucleus_morphology1.22358938
66MP0003828_pulmonary_edema1.21424925
67MP0005058_abnormal_lysosome_morphology1.21222967
68MP0001873_stomach_inflammation1.20603404
69MP0003303_peritoneal_inflammation1.15021883
70MP0004510_myositis1.10889529
71MP0002933_joint_inflammation1.05685150
72MP0004957_abnormal_blastocyst_morpholog1.04241193
73MP0000015_abnormal_ear_pigmentation1.03321041
74MP0008875_abnormal_xenobiotic_pharmacok1.01009260
75MP0002095_abnormal_skin_pigmentation1.00923079
76MP0002019_abnormal_tumor_incidence1.00044466
77MP0004381_abnormal_hair_follicle0.99807474
78MP0002277_abnormal_respiratory_mucosa0.98641311
79MP0009278_abnormal_bone_marrow0.95976926
80MP0006292_abnormal_olfactory_placode0.95630047
81MP0005310_abnormal_salivary_gland0.95519902
82MP0001851_eye_inflammation0.93368746
83MP0005165_increased_susceptibility_to0.92497462
84MP0003786_premature_aging0.92459333
85MP0003252_abnormal_bile_duct0.91088557
86MP0003866_abnormal_defecation0.90154355
87MP0006072_abnormal_retinal_apoptosis0.88963013
88MP0000372_irregular_coat_pigmentation0.86021011
89MP0000313_abnormal_cell_death0.85256244
90MP0006054_spinal_hemorrhage0.80871836
91MP0002693_abnormal_pancreas_physiology0.80832744
92MP0001919_abnormal_reproductive_system0.79720476
93MP0006035_abnormal_mitochondrial_morpho0.78976148
94MP0001542_abnormal_bone_strength0.77817940
95MP0005408_hypopigmentation0.76994399
96MP0002837_dystrophic_cardiac_calcinosis0.75616048
97MP0005319_abnormal_enzyme/_coenzyme0.75367075
98MP0003136_yellow_coat_color0.74685875
99MP0008873_increased_physiological_sensi0.73812046
100MP0005390_skeleton_phenotype0.73718823
101MP0009765_abnormal_xenobiotic_induced0.73554267
102MP0004147_increased_porphyrin_level0.72353557
103MP0000569_abnormal_digit_pigmentation0.71569977
104MP0009763_increased_sensitivity_to0.69043381
105MP0001929_abnormal_gametogenesis0.68736065
106MP0010307_abnormal_tumor_latency0.67896239
107MP0001764_abnormal_homeostasis0.67867304
108MP0001986_abnormal_taste_sensitivity0.67856513
109MP0002163_abnormal_gland_morphology0.67747139
110MP0004782_abnormal_surfactant_physiolog0.67355619
111MP0002877_abnormal_melanocyte_morpholog0.67353670
112MP0005584_abnormal_enzyme/coenzyme_acti0.67342468
113MP0003075_altered_response_to0.66607463
114MP0001905_abnormal_dopamine_level0.66328813
115MP0003638_abnormal_response/metabolism_0.66304382
116MP0008877_abnormal_DNA_methylation0.65405180
117MP0002876_abnormal_thyroid_physiology0.65340154
118MP0002210_abnormal_sex_determination0.64584520
119MP0005409_darkened_coat_color0.63849608
120MP0003656_abnormal_erythrocyte_physiolo0.62300279
121MP0001119_abnormal_female_reproductive0.60421025
122MP0003943_abnormal_hepatobiliary_system0.59378439
123MP0002998_abnormal_bone_remodeling0.58812071
124MP0008932_abnormal_embryonic_tissue0.56143621
125MP0005164_abnormal_response_to0.55093946
126MP0005166_decreased_susceptibility_to0.51696278
127MP0003172_abnormal_lysosome_physiology0.50564675

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.51693677
2Recurrent bacterial skin infections (HP:0005406)4.74069379
3Eczematoid dermatitis (HP:0000976)4.33446690
4Elevated erythrocyte sedimentation rate (HP:0003565)4.28897547
5Reticulocytopenia (HP:0001896)4.22193491
6Abnormality of cells of the erythroid lineage (HP:0012130)3.91056307
7Acute necrotizing encephalopathy (HP:0006965)3.85123928
8Mitochondrial inheritance (HP:0001427)3.83208859
9Myositis (HP:0100614)3.69320678
10Abnormal number of erythroid precursors (HP:0012131)3.68408169
11Abnormal mitochondria in muscle tissue (HP:0008316)3.65704034
12Hepatocellular necrosis (HP:0001404)3.60068806
13Obstructive lung disease (HP:0006536)3.53546577
14Chronic obstructive pulmonary disease (HP:0006510)3.53546577
15Mediastinal lymphadenopathy (HP:0100721)3.49475867
16IgM deficiency (HP:0002850)3.33868447
17Progressive macrocephaly (HP:0004481)3.29438100
18Hepatic necrosis (HP:0002605)3.28718419
19Increased CSF lactate (HP:0002490)3.27413616
20Petechiae (HP:0000967)3.20761348
21Abnormality of macrophages (HP:0004311)3.20286572
22Acute encephalopathy (HP:0006846)3.16458257
23Recurrent skin infections (HP:0001581)3.08015364
24Retrobulbar optic neuritis (HP:0100654)3.06757870
25Optic neuritis (HP:0100653)3.06757870
26Stomatitis (HP:0010280)3.02940231
27Recurrent gram-negative bacterial infections (HP:0005420)3.01673398
28Recurrent fungal infections (HP:0002841)2.99476549
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.96812814
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.96812814
31Orchitis (HP:0100796)2.95110517
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.92019516
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.90386856
34Absent/shortened dynein arms (HP:0200106)2.90386856
35Vacuolated lymphocytes (HP:0001922)2.80959809
36Recurrent viral infections (HP:0004429)2.75721602
37Meningitis (HP:0001287)2.75207278
38Pallor (HP:0000980)2.73924990
39Chronic otitis media (HP:0000389)2.73110498
40Recurrent bronchitis (HP:0002837)2.69522635
41Recurrent pneumonia (HP:0006532)2.69229316
42Thrombocytosis (HP:0001894)2.68997804
43Type I transferrin isoform profile (HP:0003642)2.66112638
44Exertional dyspnea (HP:0002875)2.65423437
45Increased intramyocellular lipid droplets (HP:0012240)2.65053298
46Vasculitis (HP:0002633)2.63677609
47Severe combined immunodeficiency (HP:0004430)2.57134322
48Autoimmune hemolytic anemia (HP:0001890)2.55025525
49Recurrent sinusitis (HP:0011108)2.52878332
50Thyroiditis (HP:0100646)2.52389577
51Chromsome breakage (HP:0040012)2.50653761
52IgG deficiency (HP:0004315)2.49525002
53Chronic mucocutaneous candidiasis (HP:0002728)2.46096495
54Recurrent cutaneous fungal infections (HP:0011370)2.46096495
55Congenital, generalized hypertrichosis (HP:0004540)2.46085370
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.45632609
57Abnormality of the prostate (HP:0008775)2.42755943
58Nasal polyposis (HP:0100582)2.42076448
59Agnosia (HP:0010524)2.39392381
60Macrocytic anemia (HP:0001972)2.38922054
61Increased hepatocellular lipid droplets (HP:0006565)2.38647414
62Poor head control (HP:0002421)2.38576418
63Combined immunodeficiency (HP:0005387)2.36115263
64Cerebral edema (HP:0002181)2.35233943
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.35212532
6611 pairs of ribs (HP:0000878)2.34986387
67Panhypogammaglobulinemia (HP:0003139)2.33790103
68Pustule (HP:0200039)2.33503281
69Leukocytosis (HP:0001974)2.33306140
70Hypoproteinemia (HP:0003075)2.31690890
71Gingivitis (HP:0000230)2.31597222
72Recurrent lower respiratory tract infections (HP:0002783)2.29271433
73Increased neuronal autofluorescent lipopigment (HP:0002074)2.29225582
74Gastrointestinal infarctions (HP:0005244)2.25383926
75Abnormality of T cells (HP:0002843)2.25302173
76Increased muscle lipid content (HP:0009058)2.25104898
77Cellulitis (HP:0100658)2.25065421
78Pulmonary fibrosis (HP:0002206)2.24589366
79Aplastic anemia (HP:0001915)2.22910514
80Abnormality of T cell number (HP:0011839)2.22220748
81Anorexia (HP:0002039)2.22125431
82Abnormal respiratory motile cilium morphology (HP:0005938)2.19904129
83Abnormal respiratory epithelium morphology (HP:0012253)2.19904129
84T lymphocytopenia (HP:0005403)2.19082208
85Lactic acidosis (HP:0003128)2.17305782
86Abnormality of liposaccharide metabolism (HP:0010968)2.15982207
87Abnormality of glycosphingolipid metabolism (HP:0004343)2.15982207
88Abnormality of glycolipid metabolism (HP:0010969)2.15982207
89Abnormality of T cell physiology (HP:0011840)2.15876004
90Hepatosplenomegaly (HP:0001433)2.15494988
91Reduced antithrombin III activity (HP:0001976)2.13400102
92Chronic diarrhea (HP:0002028)2.13291973
93Respiratory failure (HP:0002878)2.13131514
94Abnormality of eosinophils (HP:0001879)2.12136108
95Keratoconjunctivitis (HP:0001096)2.10702416
96Birth length less than 3rd percentile (HP:0003561)2.10132618
97Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.09416569
98Lymphoma (HP:0002665)2.09414228
99Renal Fanconi syndrome (HP:0001994)2.09238997
100Gangrene (HP:0100758)2.09139781
101Clubbing of toes (HP:0100760)2.07268421
102Increased serum lactate (HP:0002151)2.06723522
103Hemoptysis (HP:0002105)2.06585433
104Basal ganglia calcification (HP:0002135)2.06001800
105Urticaria (HP:0001025)2.05021297
106Acute hepatic failure (HP:0006554)2.04558099
107Keratoconjunctivitis sicca (HP:0001097)2.03626628
108Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03001683
109Pancytopenia (HP:0001876)2.01033940
110Abnormality of the nasal mucosa (HP:0000433)2.00612548
111Increased IgM level (HP:0003496)2.00071271
112Abnormality of the pleura (HP:0002103)1.99763553
113Encephalitis (HP:0002383)1.99398777
114Hypothermia (HP:0002045)1.98515527
115Chest pain (HP:0100749)1.98460860
116Lymphopenia (HP:0001888)1.98286737
117Joint swelling (HP:0001386)1.97915798
118Agammaglobulinemia (HP:0004432)1.97419147
119Periodontitis (HP:0000704)1.97336363
120Pulmonary infiltrates (HP:0002113)1.97178861
121Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.97178740
122Skin rash (HP:0000988)1.96533690
123Neutropenia (HP:0001875)1.95190391
124Optic disc pallor (HP:0000543)1.95056109
125Prostate neoplasm (HP:0100787)1.92717866
126Lipid accumulation in hepatocytes (HP:0006561)1.92296223
127Abnormality of cells of the lymphoid lineage (HP:0012140)1.92193977
128Respiratory difficulties (HP:0002880)1.91816794
129Duplicated collecting system (HP:0000081)1.91778744
130Eosinophilia (HP:0001880)1.90675506
131Abnormality of the preputium (HP:0100587)1.90604092
132Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90466165
133Granulocytopenia (HP:0001913)1.89469562
134Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89347199
135Hypergammaglobulinemia (HP:0010702)1.89164593
136B lymphocytopenia (HP:0010976)1.88420531
137Abnormality of B cell number (HP:0010975)1.88420531
1383-Methylglutaconic aciduria (HP:0003535)1.87536747
139Systemic lupus erythematosus (HP:0002725)1.87511889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.41902495
2TXK3.16946176
3VRK23.04811895
4MAP4K12.93313684
5MAP3K142.72950455
6IRAK42.56072063
7NME22.37753237
8KIT2.31074490
9BUB12.27171099
10TEC2.24386994
11VRK12.15573567
12STK162.15515684
13BMPR1B2.09668359
14IRAK31.97715671
15BTK1.97498284
16WEE11.85857066
17PBK1.81161369
18PIM21.77897680
19TYK21.76591432
20BCKDK1.75999221
21TBK11.74504077
22IKBKE1.72907047
23CLK11.70301691
24MST41.68023137
25MAP3K121.67410200
26IKBKB1.59950947
27RIPK41.59482016
28EIF2AK11.58445952
29EIF2AK21.57514551
30JAK31.55942509
31EIF2AK31.53667832
32ZAP701.52540454
33MAP4K21.49284027
34TESK21.44812300
35KDR1.43890345
36PLK41.40364286
37CSF1R1.39122709
38LIMK11.38692677
39LYN1.36639734
40BRSK21.36330078
41SYK1.35317930
42STK41.30819063
43ACVR1B1.27573924
44CDC71.22847892
45TGFBR21.22023030
46NLK1.21866850
47STK101.19517928
48YES11.16526566
49TGFBR11.14807977
50TNK21.14081455
51DAPK11.09043854
52LCK1.08649412
53TESK11.06586103
54CDK81.06332155
55ADRBK21.05241945
56SRPK11.04979969
57ITK1.02939733
58MAPKAPK30.99488442
59MKNK10.98695155
60PIM10.97936778
61RPS6KA40.95704448
62DYRK30.95300087
63SCYL20.95056386
64GRK70.95046641
65MAP3K110.94632810
66MARK30.90487922
67HCK0.89795641
68TLK10.87739432
69ATR0.79060471
70FRK0.78858104
71CHUK0.77277672
72JAK10.76233883
73NEK20.75939690
74CCNB10.75799527
75NEK90.73331210
76PTK2B0.72718041
77MATK0.71212358
78ILK0.71120716
79PRKCQ0.71010180
80AURKB0.69637865
81NUAK10.69608053
82CSK0.69347760
83LRRK20.67436608
84MOS0.66416412
85RPS6KA50.65984188
86CDK70.65295589
87CDK190.65131845
88MAP3K130.64236985
89BMPR20.64139355
90MUSK0.64004954
91GRK10.63182272
92ERN10.62962616
93CAMKK20.61292464
94MYLK0.60936440
95MAP2K60.59288432
96ABL20.59111613
97MAP2K30.59060365
98PLK10.58668901
99CSNK1G30.57663560
100OXSR10.56189401
101STK240.54359824
102FES0.53995959
103BRSK10.52991665
104ZAK0.52508042
105JAK20.50860158
106PRKCD0.48762185
107CSNK2A10.47571689
108MAP2K20.47176747
109IRAK10.43687932
110MKNK20.42825667
111MAP3K80.42180457
112TAOK30.42152951
113ARAF0.41984178
114MAPKAPK20.40445691
115INSRR0.40443875
116MAP3K30.38911438
117PIK3CG0.38566991
118ADRBK10.37579399
119ABL10.37275260
120GRK60.36778184
121IGF1R0.36342827
122FGR0.36247474
123CDK40.34670855
124MAPKAPK50.34545931
125MAPK110.34407877
126FYN0.34137066
127CSNK1G10.33988324
128CHEK20.33028843
129PASK0.32646726
130MAPK40.32436497
131CSNK1A1L0.31856506
132PAK10.28772958

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.53617860
2DNA replication_Homo sapiens_hsa030303.10343464
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.74238102
4Proteasome_Homo sapiens_hsa030502.71997905
5Mismatch repair_Homo sapiens_hsa034302.42043575
6Graft-versus-host disease_Homo sapiens_hsa053322.40825141
7Primary immunodeficiency_Homo sapiens_hsa053402.23099203
8Allograft rejection_Homo sapiens_hsa053302.15605797
9Leishmaniasis_Homo sapiens_hsa051402.10939395
10Homologous recombination_Homo sapiens_hsa034402.09412445
11Base excision repair_Homo sapiens_hsa034102.00238674
12RNA polymerase_Homo sapiens_hsa030201.98440534
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95047302
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.88089417
15Legionellosis_Homo sapiens_hsa051341.78959565
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.78775347
17Measles_Homo sapiens_hsa051621.76315296
18Pyrimidine metabolism_Homo sapiens_hsa002401.69935957
19Spliceosome_Homo sapiens_hsa030401.64418620
20Nucleotide excision repair_Homo sapiens_hsa034201.63139150
21Hematopoietic cell lineage_Homo sapiens_hsa046401.61728723
22Fanconi anemia pathway_Homo sapiens_hsa034601.61245420
23Antigen processing and presentation_Homo sapiens_hsa046121.60979848
24Herpes simplex infection_Homo sapiens_hsa051681.58129669
25Protein export_Homo sapiens_hsa030601.52003215
26Asthma_Homo sapiens_hsa053101.49974020
27Non-homologous end-joining_Homo sapiens_hsa034501.45799650
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45697286
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45381919
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41562059
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40101822
32Pertussis_Homo sapiens_hsa051331.37308655
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37011223
34Malaria_Homo sapiens_hsa051441.36043714
35Staphylococcus aureus infection_Homo sapiens_hsa051501.34110306
36Osteoclast differentiation_Homo sapiens_hsa043801.30441777
37Basal transcription factors_Homo sapiens_hsa030221.28705743
38RNA degradation_Homo sapiens_hsa030181.19522627
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15492240
40Salmonella infection_Homo sapiens_hsa051321.13935276
41Influenza A_Homo sapiens_hsa051641.13756323
42Autoimmune thyroid disease_Homo sapiens_hsa053201.13095231
43B cell receptor signaling pathway_Homo sapiens_hsa046621.09269731
44p53 signaling pathway_Homo sapiens_hsa041151.08252796
45Rheumatoid arthritis_Homo sapiens_hsa053231.05434652
46Cell cycle_Homo sapiens_hsa041101.05162023
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04988137
48Tuberculosis_Homo sapiens_hsa051521.03306905
49Other glycan degradation_Homo sapiens_hsa005111.03153316
50Type I diabetes mellitus_Homo sapiens_hsa049401.00826852
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.00253039
52Epstein-Barr virus infection_Homo sapiens_hsa051690.98453196
53One carbon pool by folate_Homo sapiens_hsa006700.96659502
54RNA transport_Homo sapiens_hsa030130.93663695
55Shigellosis_Homo sapiens_hsa051310.92515012
56Collecting duct acid secretion_Homo sapiens_hsa049660.92394955
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91384593
58Apoptosis_Homo sapiens_hsa042100.89294534
59Arachidonic acid metabolism_Homo sapiens_hsa005900.88687349
60Systemic lupus erythematosus_Homo sapiens_hsa053220.86596646
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84684770
62Purine metabolism_Homo sapiens_hsa002300.82662346
63Toxoplasmosis_Homo sapiens_hsa051450.81950676
64T cell receptor signaling pathway_Homo sapiens_hsa046600.81001050
65TNF signaling pathway_Homo sapiens_hsa046680.79957636
66Viral myocarditis_Homo sapiens_hsa054160.78975625
67Phagosome_Homo sapiens_hsa041450.78848789
68Oxidative phosphorylation_Homo sapiens_hsa001900.77709707
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77253283
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76850154
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75827725
72Hepatitis B_Homo sapiens_hsa051610.75323001
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75296708
74Sulfur metabolism_Homo sapiens_hsa009200.74950366
75African trypanosomiasis_Homo sapiens_hsa051430.73745607
76Fatty acid elongation_Homo sapiens_hsa000620.73262220
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.72041767
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.70664460
79Regulation of autophagy_Homo sapiens_hsa041400.70492183
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70230415
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67165787
82Lysosome_Homo sapiens_hsa041420.65772324
83Caffeine metabolism_Homo sapiens_hsa002320.65691549
84Parkinsons disease_Homo sapiens_hsa050120.64862891
85Huntingtons disease_Homo sapiens_hsa050160.62336112
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62087651
87Cardiac muscle contraction_Homo sapiens_hsa042600.61825155
88Chemokine signaling pathway_Homo sapiens_hsa040620.61553968
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.60185187
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58771720
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57857601
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56454702
93Ether lipid metabolism_Homo sapiens_hsa005650.56440338
94Viral carcinogenesis_Homo sapiens_hsa052030.54199259
95Peroxisome_Homo sapiens_hsa041460.52084168
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51100636
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51041215
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49400544
99Linoleic acid metabolism_Homo sapiens_hsa005910.48212189
100HTLV-I infection_Homo sapiens_hsa051660.45783144
101Nitrogen metabolism_Homo sapiens_hsa009100.42311064
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40704918
103Sphingolipid metabolism_Homo sapiens_hsa006000.39294766
104Alzheimers disease_Homo sapiens_hsa050100.37459770
105N-Glycan biosynthesis_Homo sapiens_hsa005100.37403322
106Pentose phosphate pathway_Homo sapiens_hsa000300.36542723
107Hepatitis C_Homo sapiens_hsa051600.36416979
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35154182
109Metabolic pathways_Homo sapiens_hsa011000.34332089
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34010119
111Folate biosynthesis_Homo sapiens_hsa007900.33396862
112Platelet activation_Homo sapiens_hsa046110.33302574
113Glutathione metabolism_Homo sapiens_hsa004800.32530012
114Chemical carcinogenesis_Homo sapiens_hsa052040.31886786
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29513627
116Small cell lung cancer_Homo sapiens_hsa052220.29137903
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27148180
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26481960
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23044308

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