ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	desmosome organization (GO:0002934)	5.95108952
2	synaptic vesicle docking involved in exocytosis (GO:0016081)	5.58715947
3	glutamate secretion (GO:0014047)	5.44039964
4	synaptic vesicle maturation (GO:0016188)	5.16776888
5	sodium ion export (GO:0071436)	5.03440590
6	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.86418392
7	cellular potassium ion homeostasis (GO:0030007)	4.68190768
8	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.61703732
9	synaptic vesicle exocytosis (GO:0016079)	4.41759277
10	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	4.27229617
11	neurotransmitter secretion (GO:0007269)	4.07853553
12	regulation of synaptic vesicle exocytosis (GO:2000300)	4.03436320
13	regulation of water loss via skin (GO:0033561)	4.01024889
14	NADH metabolic process (GO:0006734)	3.99963608
15	positive regulation of synapse maturation (GO:0090129)	3.85912737
16	cell communication involved in cardiac conduction (GO:0086065)	3.73380209
17	establishment of skin barrier (GO:0061436)	3.72244473
18	multicellular organismal water homeostasis (GO:0050891)	3.49225817
19	regulation of heart rate by cardiac conduction (GO:0086091)	3.48609482
20	regulation of synaptic vesicle transport (GO:1902803)	3.41750194
21	potassium ion homeostasis (GO:0055075)	3.39054290
22	intestinal epithelial cell development (GO:0060576)	3.36554915
23	neurotransmitter transport (GO:0006836)	3.32668248
24	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.30709610
25	hemidesmosome assembly (GO:0031581)	3.28873440
26	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.28148910
27	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.22128307
28	cardiac conduction (GO:0061337)	3.21141587
29	regulation of neuronal synaptic plasticity (GO:0048168)	3.19913592
30	vocalization behavior (GO:0071625)	3.19181490
31	dendritic spine organization (GO:0097061)	3.16759990
32	regulation of neurotransmitter levels (GO:0001505)	2.92822886
33	cerebellar Purkinje cell layer development (GO:0021680)	2.90267781
34	negative regulation of dendrite morphogenesis (GO:0050774)	2.89480479
35	synaptic vesicle endocytosis (GO:0048488)	2.88286274
36	regulation of guanylate cyclase activity (GO:0031282)	2.86571555
37	regulation of long-term neuronal synaptic plasticity (GO:0048169)	2.85412572
38	dendritic spine morphogenesis (GO:0060997)	2.84883293
39	cellular sodium ion homeostasis (GO:0006883)	2.83070782
40	GDP-mannose metabolic process (GO:0019673)	2.82174240
41	water homeostasis (GO:0030104)	2.81472139
42	cell communication by electrical coupling (GO:0010644)	2.81184445
43	intermediate filament organization (GO:0045109)	2.79834400
44	layer formation in cerebral cortex (GO:0021819)	2.77203220
45	ventricular cardiac muscle cell action potential (GO:0086005)	2.69597924
46	cerebellar granule cell differentiation (GO:0021707)	2.69565631
47	proline transport (GO:0015824)	2.67936994
48	cochlea development (GO:0090102)	2.67747621
49	sodium ion homeostasis (GO:0055078)	2.64839640
50	regulation of synapse maturation (GO:0090128)	2.64726110
51	regulation of synaptic plasticity (GO:0048167)	2.60723156
52	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.58861173
53	response to histamine (GO:0034776)	2.55204982
54	keratinization (GO:0031424)	2.55110517
55	nucleoside diphosphate biosynthetic process (GO:0009133)	2.52943694
56	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.52026572
57	chemosensory behavior (GO:0007635)	2.51611441
58	potassium ion import (GO:0010107)	2.50418797
59	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	2.49826127
60	positive regulation of membrane potential (GO:0045838)	2.48367542
61	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.46715668
62	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.44999114
63	regulation of ARF protein signal transduction (GO:0032012)	2.44400663
64	negative regulation of keratinocyte proliferation (GO:0010839)	2.43782103
65	tricarboxylic acid cycle (GO:0006099)	2.43627448
66	myelin maintenance (GO:0043217)	2.43543898
67	locomotory exploration behavior (GO:0035641)	2.43007189
68	negative regulation of microtubule polymerization (GO:0031115)	2.42302292
69	cardiac muscle cell action potential involved in contraction (GO:0086002)	2.41812902
70	positive regulation of respiratory burst (GO:0060267)	2.41689813
71	oxaloacetate metabolic process (GO:0006107)	2.39185899
72	apical protein localization (GO:0045176)	2.38553303
73	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.38470491
74	glucose 6-phosphate metabolic process (GO:0051156)	2.38125449
75	proline biosynthetic process (GO:0006561)	2.37733641
76	innervation (GO:0060384)	2.34917925
77	membrane repolarization (GO:0086009)	2.34721083
78	regulation of clathrin-mediated endocytosis (GO:2000369)	2.32572541
79	glutathione biosynthetic process (GO:0006750)	2.31679047
80	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.31120919
81	signal release (GO:0023061)	2.29773880
82	exploration behavior (GO:0035640)	2.29383328
83	regulation of vesicle fusion (GO:0031338)	2.27874567
84	positive regulation of neurotransmitter secretion (GO:0001956)	2.27521980
85	mating behavior (GO:0007617)	2.26599852
86	cardiac muscle cell action potential (GO:0086001)	2.26304372
87	dicarboxylic acid transport (GO:0006835)	2.25800360
88	activation of Rac GTPase activity (GO:0032863)	2.25380105
89	positive regulation of sodium ion transport (GO:0010765)	2.25183010
90	regulation of cellular respiration (GO:0043457)	2.25117375
91	neuronal action potential propagation (GO:0019227)	2.24847436
92	synaptic vesicle transport (GO:0048489)	2.24263484
93	establishment of synaptic vesicle localization (GO:0097480)	2.24263484
94	neuromuscular process controlling balance (GO:0050885)	2.24016485
95	positive regulation of neurotransmitter transport (GO:0051590)	2.23894661
96	neuronal ion channel clustering (GO:0045161)	2.22969375
97	membrane hyperpolarization (GO:0060081)	2.22825641
98	neutral amino acid transport (GO:0015804)	2.22787575
99	multicellular organismal signaling (GO:0035637)	2.21995200
100	long term synaptic depression (GO:0060292)	2.21414715

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	5.56179695
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.32688200
3	ZNF263_19887448_ChIP-Seq_K562_Human	2.57350771
4	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.53346825
5	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	2.46612868
6	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.40446650
7	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.32893702
8	RARB_27405468_Chip-Seq_BRAIN_Mouse	2.23421889
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.19752368
10	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.19053625
11	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.17004814
12	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.16391153
13	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.11486044
14	RACK7_27058665_Chip-Seq_MCF-7_Human	2.09823688
15	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.91338635
16	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.88141284
17	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.84922277
18	REST_21632747_ChIP-Seq_MESCs_Mouse	1.84288745
19	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.71384502
20	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.70051510
21	AR_21909140_ChIP-Seq_LNCAP_Human	1.67187290
22	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.67094785
23	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.66550289
24	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.66239815
25	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.65151514
26	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.64306341
27	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.62529131
28	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.61431886
29	CTCF_27219007_Chip-Seq_Bcells_Human	1.54301441
30	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.53535270
31	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.53189195
32	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.51833908
33	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.50518115
34	DROSHA_22980978_ChIP-Seq_HELA_Human	1.49862694
35	LXR_22292898_ChIP-Seq_THP-1_Human	1.48669106
36	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.45722633
37	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.43797327
38	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.41578627
39	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.38625017
40	GATA6_25053715_ChIP-Seq_YYC3_Human	1.38572859
41	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.38440850
42	CREB1_26743006_Chip-Seq_LNCaP_Human	1.37039750
43	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.35813563
44	SMC4_20622854_ChIP-Seq_HELA_Human	1.31688180
45	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.31404933
46	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.30954256
47	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.30003293
48	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.29969047
49	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.29627374
50	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.29171686
51	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.28496394
52	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.28447741
53	SOX2_20726797_ChIP-Seq_SW620_Human	1.27160585
54	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.27010719
55	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.26623811
56	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.26090705
57	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.25776713
58	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.24788416
59	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.22313293
60	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.21725460
61	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.17681923
62	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.17454537
63	KDM2B_26808549_Chip-Seq_K562_Human	1.16379653
64	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.14901049
65	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.14281459
66	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.14281459
67	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.14231687
68	P68_20966046_ChIP-Seq_HELA_Human	1.13620703
69	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.12077657
70	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11260803
71	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.09929374
72	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.09717361
73	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.08579550
74	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.07509969
75	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.07486865
76	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.07068396
77	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.05705467
78	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.05686696
79	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.04041169
80	KLF5_25053715_ChIP-Seq_YYC3_Human	1.03578605
81	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.03574634
82	SA1_27219007_Chip-Seq_Bcells_Human	1.03360426
83	* TP63_22573176_ChIP-Seq_HFKS_Human	1.03246645
84	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.00678420
85	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.00161827
86	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.98396483
87	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.97821304
88	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.97604818
89	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.97408659
90	* CHD1_26751641_Chip-Seq_LNCaP_Human	0.97052045
91	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.94660995
92	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.94415504
93	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.94166763
94	ATF3_27146783_Chip-Seq_COLON_Human	0.92071987
95	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.89392301
96	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.89230863
97	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.89159996
98	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.89056623
99	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.88475542
100	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.87124677

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	6.21691201
2	MP0004270_analgesia	4.15928759
3	MP0000579_abnormal_nail_morphology	3.62173057
4	MP0002796_impaired_skin_barrier	3.49978556
5	MP0004859_abnormal_synaptic_plasticity	3.37176903
6	MP0003880_abnormal_central_pattern	3.00123779
7	MP0004264_abnormal_extraembryonic_tissu	2.54927136
8	MP0009780_abnormal_chondrocyte_physiolo	2.22491990
9	MP0000566_synostosis	2.19633472
10	MP0003941_abnormal_skin_development	2.09378389
11	MP0002734_abnormal_mechanical_nocicepti	2.08399128
12	MP0003635_abnormal_synaptic_transmissio	2.07896950
13	MP0005501_abnormal_skin_physiology	2.06981439
14	MP0003123_paternal_imprinting	2.04402343
15	MP0002064_seizures	1.99809525
16	MP0001188_hyperpigmentation	1.96790909
17	MP0003879_abnormal_hair_cell	1.87816043
18	MP0002098_abnormal_vibrissa_morphology	1.86449215
19	MP0010678_abnormal_skin_adnexa	1.78488784
20	MP0002822_catalepsy	1.78415304
21	MP0009745_abnormal_behavioral_response	1.77360927
22	MP0004147_increased_porphyrin_level	1.76321152
23	MP0005423_abnormal_somatic_nervous	1.73260307
24	MP0010352_gastrointestinal_tract_polyps	1.65267936
25	MP0004043_abnormal_pH_regulation	1.62346209
26	MP0002063_abnormal_learning/memory/cond	1.62127827
27	MP0002272_abnormal_nervous_system	1.58856464
28	MP0009046_muscle_twitch	1.55120741
29	MP0009379_abnormal_foot_pigmentation	1.50511324
30	MP0004782_abnormal_surfactant_physiolog	1.50039981
31	MP0000678_abnormal_parathyroid_gland	1.48873664
32	MP0002909_abnormal_adrenal_gland	1.44096909
33	MP0004019_abnormal_vitamin_homeostasis	1.40840716
34	MP0003787_abnormal_imprinting	1.39092913
35	MP0001968_abnormal_touch/_nociception	1.38171050
36	MP0001666_abnormal_nutrient_absorption	1.38034988
37	MP0005409_darkened_coat_color	1.37277763
38	MP0003329_amyloid_beta_deposits	1.36661144
39	MP0000467_abnormal_esophagus_morphology	1.35066789
40	MP0002572_abnormal_emotion/affect_behav	1.34115934
41	MP0001765_abnormal_ion_homeostasis	1.33061631
42	MP0000537_abnormal_urethra_morphology	1.30366037
43	MP0008569_lethality_at_weaning	1.25567572
44	MP0001664_abnormal_digestion	1.25122392
45	MP0000377_abnormal_hair_follicle	1.22654502
46	MP0002736_abnormal_nociception_after	1.22390832
47	MP0001486_abnormal_startle_reflex	1.22093684
48	MP0003693_abnormal_embryo_hatching	1.21381299
49	MP0001216_abnormal_epidermal_layer	1.20059057
50	MP0010771_integument_phenotype	1.17468194
51	MP0001501_abnormal_sleep_pattern	1.16965796
52	MP0005360_urolithiasis	1.14012653
53	MP0000762_abnormal_tongue_morphology	1.11904978
54	MP0003183_abnormal_peptide_metabolism	1.11028902
55	MP0000427_abnormal_hair_cycle	1.08913699
56	MP0001346_abnormal_lacrimal_gland	1.08851239
57	MP0000462_abnormal_digestive_system	1.08340507
58	MP0001970_abnormal_pain_threshold	1.01337026
59	MP0004885_abnormal_endolymph	1.00549101
60	MP0003705_abnormal_hypodermis_morpholog	0.99482189
61	MP0009672_abnormal_birth_weight	0.97557182
62	MP0000383_abnormal_hair_follicle	0.96955443
63	MP0003453_abnormal_keratinocyte_physiol	0.96849779
64	MP0002733_abnormal_thermal_nociception	0.94917474
65	MP0001485_abnormal_pinna_reflex	0.94595092
66	MP0005636_abnormal_mineral_homeostasis	0.93307913
67	MP0005646_abnormal_pituitary_gland	0.88272120
68	MP0002557_abnormal_social/conspecific_i	0.86846008
69	MP0002876_abnormal_thyroid_physiology	0.84710268
70	MP0001440_abnormal_grooming_behavior	0.84177897
71	MP0004811_abnormal_neuron_physiology	0.82894844
72	MP0003315_abnormal_perineum_morphology	0.80699388
73	MP0002066_abnormal_motor_capabilities/c	0.80051969
74	MP0003866_abnormal_defecation	0.78868384
75	MP0004957_abnormal_blastocyst_morpholog	0.78171291
76	MP0004924_abnormal_behavior	0.76006037
77	MP0005386_behavior/neurological_phenoty	0.76006037
78	MP0002069_abnormal_eating/drinking_beha	0.75890341
79	MP0002229_neurodegeneration	0.75772973
80	MP0000627_abnormal_mammary_gland	0.75134793
81	MP0000647_abnormal_sebaceous_gland	0.75015790
82	MP0004858_abnormal_nervous_system	0.74546810
83	MP0002067_abnormal_sensory_capabilities	0.73720670
84	MP0002184_abnormal_innervation	0.73633411
85	MP0002234_abnormal_pharynx_morphology	0.73356541
86	MP0002735_abnormal_chemical_nociception	0.73332351
87	MP0005332_abnormal_amino_acid	0.73071946
88	MP0001905_abnormal_dopamine_level	0.71728887
89	MP0003122_maternal_imprinting	0.69892157
90	MP0002060_abnormal_skin_morphology	0.69521555
91	MP0000477_abnormal_intestine_morphology	0.68662882
92	MP0002882_abnormal_neuron_morphology	0.68133184
93	MP0005085_abnormal_gallbladder_physiolo	0.67876542
94	MP0003283_abnormal_digestive_organ	0.66648415
95	MP0000538_abnormal_urinary_bladder	0.66415473
96	MP0001502_abnormal_circadian_rhythm	0.65659652
97	MP0001881_abnormal_mammary_gland	0.63493112
98	MP0001177_atelectasis	0.62853201
99	MP0008872_abnormal_physiological_respon	0.62645279
100	MP0005083_abnormal_biliary_tract	0.62589954

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	4.95083005
2	Pili torti (HP:0003777)	4.94336604
3	Abnormality of nail color (HP:0100643)	4.17839611
4	Right ventricular cardiomyopathy (HP:0011663)	4.12944144
5	Hyperactive renin-angiotensin system (HP:0000841)	3.65912449
6	Ankle clonus (HP:0011448)	3.61249685
7	Abnormal hair laboratory examination (HP:0003328)	3.52901803
8	Plantar hyperkeratosis (HP:0007556)	3.34769441
9	Palmoplantar hyperkeratosis (HP:0000972)	3.26515935
10	Akinesia (HP:0002304)	3.05064437
11	Palmar hyperkeratosis (HP:0010765)	3.04803659
12	Focal motor seizures (HP:0011153)	2.99543063
13	Congenital ichthyosiform erythroderma (HP:0007431)	2.72902875
14	Onycholysis (HP:0001806)	2.71470360
15	Fragile nails (HP:0001808)	2.69762852
16	Hypoglycemic coma (HP:0001325)	2.67999491
17	Abnormality of renin-angiotensin system (HP:0000847)	2.64203346
18	Symptomatic seizures (HP:0011145)	2.61645996
19	Hypoglycemic seizures (HP:0002173)	2.55683802
20	Alopecia of scalp (HP:0002293)	2.54841415
21	Epileptic encephalopathy (HP:0200134)	2.46588609
22	Septate vagina (HP:0001153)	2.44364562
23	Supranuclear gaze palsy (HP:0000605)	2.43323492
24	Focal seizures (HP:0007359)	2.41079318
25	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.37030177
26	Hyperinsulinemic hypoglycemia (HP:0000825)	2.36819337
27	Cerebral hypomyelination (HP:0006808)	2.33267408
28	Diminished movement (HP:0002374)	2.28847254
29	Abnormality of the salivary glands (HP:0010286)	2.28069702
30	Sparse eyelashes (HP:0000653)	2.27472045
31	Action tremor (HP:0002345)	2.26267882
32	Hypotrichosis (HP:0001006)	2.25885027
33	Decreased circulating renin level (HP:0003351)	2.24939090
34	Woolly hair (HP:0002224)	2.24925053
35	Hypokinesia (HP:0002375)	2.24315368
36	Milia (HP:0001056)	2.20816619
37	Gout (HP:0001997)	2.16698394
38	Limb dystonia (HP:0002451)	2.14888290
39	Epileptiform EEG discharges (HP:0011182)	2.13481172
40	Syncope (HP:0001279)	2.12424315
41	Metabolic alkalosis (HP:0200114)	2.10071746
42	Neonatal onset (HP:0003623)	2.08841243
43	Hyperparathyroidism (HP:0000843)	2.01459483
44	EEG with generalized epileptiform discharges (HP:0011198)	2.01316199
45	Hyperaldosteronism (HP:0000859)	1.99957227
46	Ventricular fibrillation (HP:0001663)	1.99921200
47	Generalized tonic-clonic seizures (HP:0002069)	1.98789572
48	Curly hair (HP:0002212)	1.98146839
49	Hyperphosphatemia (HP:0002905)	1.98124538
50	Abnormality of glycolysis (HP:0004366)	1.96723307
51	Atonic seizures (HP:0010819)	1.96037974
52	Febrile seizures (HP:0002373)	1.94318887
53	Impaired vibration sensation in the lower limbs (HP:0002166)	1.93046180
54	Hypsarrhythmia (HP:0002521)	1.92590407
55	Amelogenesis imperfecta (HP:0000705)	1.92260366
56	Widely patent fontanelles and sutures (HP:0004492)	1.91675824
57	Nail dystrophy (HP:0008404)	1.90806844
58	Intention tremor (HP:0002080)	1.89722366
59	Depression (HP:0000716)	1.89422511
60	Spinal cord compression (HP:0002176)	1.89409385
61	Lip pit (HP:0100267)	1.86879617
62	Dysmetria (HP:0001310)	1.86556534
63	Confusion (HP:0001289)	1.84906053
64	Tetraplegia (HP:0002445)	1.80604954
65	Poor suck (HP:0002033)	1.78663459
66	Conjunctival hamartoma (HP:0100780)	1.76771323
67	Abnormality of chloride homeostasis (HP:0011422)	1.76689105
68	Hypoplasia of dental enamel (HP:0006297)	1.75629745
69	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.75578336
70	Clonus (HP:0002169)	1.74042988
71	Double outlet right ventricle (HP:0001719)	1.73376512
72	Congenital malformation of the right heart (HP:0011723)	1.73376512
73	Visual hallucinations (HP:0002367)	1.73151826
74	Malnutrition (HP:0004395)	1.72557901
75	Spastic gait (HP:0002064)	1.70121158
76	Abnormal eating behavior (HP:0100738)	1.70091226
77	Abnormality of vitamin B metabolism (HP:0004340)	1.69502592
78	Flat acetabular roof (HP:0003180)	1.68702170
79	Dysmetric saccades (HP:0000641)	1.68468386
80	Alkalosis (HP:0001948)	1.68397099
81	Ketoacidosis (HP:0001993)	1.68202126
82	Torticollis (HP:0000473)	1.67183480
83	Abdominal distention (HP:0003270)	1.66168172
84	Hyperglycinuria (HP:0003108)	1.65708023
85	Hyponatremia (HP:0002902)	1.64134840
86	Abnormality of vitamin metabolism (HP:0100508)	1.64092156
87	Dehydration (HP:0001944)	1.63887157
88	Urinary urgency (HP:0000012)	1.63536946
89	Hypotension (HP:0002615)	1.62703156
90	Megaloblastic anemia (HP:0001889)	1.62372328
91	Anxiety (HP:0000739)	1.61421593
92	Muscular hypotonia of the trunk (HP:0008936)	1.60333455
93	Hamartoma of the eye (HP:0010568)	1.59902676
94	Apathy (HP:0000741)	1.58416572
95	Bundle branch block (HP:0011710)	1.55930824
96	Ependymoma (HP:0002888)	1.54080622
97	Acute encephalopathy (HP:0006846)	1.53968855
98	Focal dystonia (HP:0004373)	1.53935363
99	Abnormality of permanent molar morphology (HP:0011071)	1.53629202
100	Taurodontia (HP:0000679)	1.53629202

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST1R	4.18593523
2	EPHA4	3.61311198
3	EPHA2	3.60418298
4	MAP3K9	3.24947236
5	RIPK1	2.53947627
6	DAPK2	2.30194618
7	LMTK2	1.99804393
8	NTRK3	1.96004608
9	MET	1.93970288
10	MINK1	1.83358579
11	MAP3K12	1.78609882
12	TESK1	1.77804921
13	NME1	1.71532418
14	DAPK1	1.67342696
15	TRIB3	1.65253526
16	NTRK1	1.57060250
17	ARAF	1.56819327
18	UHMK1	1.55103034
19	FER	1.53419172
20	PHKG1	1.50335909
21	PHKG2	1.50335909
22	MAP3K2	1.49355055
23	CAMKK1	1.44239510
24	PRKD3	1.41886332
25	LATS2	1.40547777
26	CASK	1.39928123
27	PAK6	1.39563947
28	SMG1	1.36831896
29	PRKG2	1.34905581
30	OXSR1	1.32454504
31	TSSK6	1.22744430
32	PRKCI	1.22349673
33	NEK6	1.20957304
34	ALK	1.20652405
35	GRK5	1.07032743
36	MARK1	1.06567727
37	STK39	1.04513861
38	TTK	1.03938608
39	CAMK2B	1.03492963
40	BRSK1	1.01132844
41	NEK1	1.00531203
42	PIK3CA	1.00079130
43	MAP2K6	0.99521641
44	STK24	0.98444525
45	PBK	0.98289086
46	CDK5	0.97063894
47	PTK2	0.96459155
48	RPS6KB2	0.92526864
49	CDK18	0.91111250
50	CDK15	0.90779375
51	CAMK2G	0.88864043
52	NME2	0.88471570
53	ACVR1B	0.86119453
54	CDK12	0.86054714
55	WNK4	0.85387247
56	EIF2AK1	0.85075978
57	MAPKAPK3	0.84352517
58	PKN2	0.83981637
59	PAK3	0.83343103
60	MST4	0.81657928
61	CDK11A	0.81341167
62	CAMK2D	0.81003734
63	BRAF	0.79579470
64	EEF2K	0.79399971
65	CDK14	0.78439717
66	KSR2	0.75844632
67	PAK4	0.73585590
68	CSNK1E	0.70862328
69	LIMK1	0.69956340
70	FGFR2	0.69883745
71	CAMK1D	0.69085984
72	NTRK2	0.68760861
73	TAOK1	0.66517749
74	BUB1	0.64863239
75	SCYL2	0.64742640
76	TRIM28	0.63417989
77	PDPK1	0.63298356
78	PTK6	0.62454406
79	CDK19	0.61771866
80	CAMK1G	0.59175485
81	ERBB2	0.58601569
82	PRKCG	0.56240616
83	CAMK2A	0.52543156
84	CSNK1G3	0.51577788
85	IRAK2	0.51289969
86	CSNK1A1	0.51213864
87	MAP2K2	0.50495845
88	PLK2	0.50387453
89	CSNK1G2	0.49012196
90	PRKCH	0.47713303
91	MAP2K7	0.46018385
92	PDK2	0.45585433
93	DAPK3	0.43581824
94	PINK1	0.43365541
95	MAP3K4	0.43217571
96	CAMK1	0.42851444
97	TESK2	0.42530327
98	CSNK1G1	0.40302228
99	PRKCZ	0.40114663
100	PRKCA	0.35203279

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	3.21540381
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.86970706
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.65590002
4	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.53331302
5	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.45551204
6	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.38054441
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.19246136
8	Sulfur metabolism_Homo sapiens_hsa00920	2.10670960
9	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.03159858
10	Nicotine addiction_Homo sapiens_hsa05033	1.84487940
11	Insulin secretion_Homo sapiens_hsa04911	1.83263370
12	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.72292446
13	Mineral absorption_Homo sapiens_hsa04978	1.67803731
14	Amphetamine addiction_Homo sapiens_hsa05031	1.62454709
15	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.59410398
16	Vibrio cholerae infection_Homo sapiens_hsa05110	1.54546603
17	Long-term potentiation_Homo sapiens_hsa04720	1.51270437
18	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.50889290
19	Fatty acid elongation_Homo sapiens_hsa00062	1.42394812
20	* Arginine and proline metabolism_Homo sapiens_hsa00330	1.41991920
21	Histidine metabolism_Homo sapiens_hsa00340	1.40711700
22	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.39299410
23	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.37724748
24	Pancreatic secretion_Homo sapiens_hsa04972	1.26217607
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.23722903
26	Dopaminergic synapse_Homo sapiens_hsa04728	1.21276525
27	Phenylalanine metabolism_Homo sapiens_hsa00360	1.21071977
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.19528998
29	Collecting duct acid secretion_Homo sapiens_hsa04966	1.15611363
30	Fat digestion and absorption_Homo sapiens_hsa04975	1.15252398
31	GABAergic synapse_Homo sapiens_hsa04727	1.12978991
32	Bile secretion_Homo sapiens_hsa04976	1.12789460
33	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.12405163
34	Folate biosynthesis_Homo sapiens_hsa00790	1.08109815
35	Circadian entrainment_Homo sapiens_hsa04713	1.07563431
36	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.06121276
37	Gastric acid secretion_Homo sapiens_hsa04971	1.05788730
38	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.05345274
39	Pyruvate metabolism_Homo sapiens_hsa00620	1.04310068
40	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.03458895
41	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.03379465
42	Oxidative phosphorylation_Homo sapiens_hsa00190	1.01988507
43	Carbon metabolism_Homo sapiens_hsa01200	1.01557684
44	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.00014389
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.98884592
46	Galactose metabolism_Homo sapiens_hsa00052	0.98289391
47	Cocaine addiction_Homo sapiens_hsa05030	0.96782646
48	Salivary secretion_Homo sapiens_hsa04970	0.95983690
49	Renin-angiotensin system_Homo sapiens_hsa04614	0.95218212
50	Renin secretion_Homo sapiens_hsa04924	0.93233902
51	Oocyte meiosis_Homo sapiens_hsa04114	0.91569914
52	Alzheimers disease_Homo sapiens_hsa05010	0.90178656
53	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.84765002
54	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.82171767
55	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.80762008
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.80269867
57	Tight junction_Homo sapiens_hsa04530	0.79595339
58	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.78434013
59	Glucagon signaling pathway_Homo sapiens_hsa04922	0.77994211
60	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.73593160
61	Taste transduction_Homo sapiens_hsa04742	0.72221922
62	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.72174913
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71058641
64	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.69299099
65	GnRH signaling pathway_Homo sapiens_hsa04912	0.68659518
66	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.68471421
67	Morphine addiction_Homo sapiens_hsa05032	0.67315214
68	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67204507
69	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.66470343
70	Sulfur relay system_Homo sapiens_hsa04122	0.66044400
71	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.65482250
72	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.65147740
73	Parkinsons disease_Homo sapiens_hsa05012	0.64190667
74	Cardiac muscle contraction_Homo sapiens_hsa04260	0.63459130
75	Nitrogen metabolism_Homo sapiens_hsa00910	0.62245296
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61922137
77	Long-term depression_Homo sapiens_hsa04730	0.61539819
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.60822655
79	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.60467848
80	Glutathione metabolism_Homo sapiens_hsa00480	0.60202047
81	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.59535527
82	Serotonergic synapse_Homo sapiens_hsa04726	0.57783284
83	Estrogen signaling pathway_Homo sapiens_hsa04915	0.57066145
84	Cholinergic synapse_Homo sapiens_hsa04725	0.56657263
85	Butanoate metabolism_Homo sapiens_hsa00650	0.53007346
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.52976621
87	Fatty acid degradation_Homo sapiens_hsa00071	0.52034584
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51350167
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49968181
90	Protein digestion and absorption_Homo sapiens_hsa04974	0.49315678
91	Propanoate metabolism_Homo sapiens_hsa00640	0.48220355
92	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.47810277
93	Huntingtons disease_Homo sapiens_hsa05016	0.46121381
94	Tyrosine metabolism_Homo sapiens_hsa00350	0.44708272
95	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.43271407
96	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.42827526
97	* Metabolic pathways_Homo sapiens_hsa01100	0.42694791
98	AMPK signaling pathway_Homo sapiens_hsa04152	0.42216023
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.40222161
100	Ether lipid metabolism_Homo sapiens_hsa00565	0.40134215

CKMT1A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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