CKMT1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)7.07819508
2glutamate secretion (GO:0014047)6.78021130
3synaptic vesicle maturation (GO:0016188)6.73088192
4regulation of short-term neuronal synaptic plasticity (GO:0048172)6.06945247
5sodium ion export (GO:0071436)5.93175682
6synaptic vesicle exocytosis (GO:0016079)5.89029170
7cellular potassium ion homeostasis (GO:0030007)5.85004348
8regulation of synaptic vesicle exocytosis (GO:2000300)5.38521212
9neurotransmitter secretion (GO:0007269)5.36415464
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.13281113
11positive regulation of synapse maturation (GO:0090129)5.00156220
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.75475266
13regulation of synaptic vesicle transport (GO:1902803)4.55094260
14vocalization behavior (GO:0071625)4.37002266
15neurotransmitter transport (GO:0006836)4.34913158
16regulation of neuronal synaptic plasticity (GO:0048168)4.24732113
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.24548631
18cerebellar granule cell differentiation (GO:0021707)4.17046315
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.12378317
20potassium ion homeostasis (GO:0055075)4.02685114
21regulation of long-term neuronal synaptic plasticity (GO:0048169)3.92235884
22regulation of neurotransmitter levels (GO:0001505)3.83567670
23cell communication involved in cardiac conduction (GO:0086065)3.81288927
24locomotory exploration behavior (GO:0035641)3.74794828
25desmosome organization (GO:0002934)3.73426134
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.69834614
27regulation of synapse maturation (GO:0090128)3.66350178
28L-amino acid import (GO:0043092)3.62967260
29cell communication by electrical coupling (GO:0010644)3.61795887
30cytoskeletal anchoring at plasma membrane (GO:0007016)3.55682807
31synaptic vesicle endocytosis (GO:0048488)3.49898650
32dendritic spine morphogenesis (GO:0060997)3.49577163
33cellular sodium ion homeostasis (GO:0006883)3.46441927
34positive regulation of membrane potential (GO:0045838)3.44271921
35regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.42657865
36potassium ion import (GO:0010107)3.41313150
37amino acid import (GO:0043090)3.40306237
38cerebellar Purkinje cell layer development (GO:0021680)3.40165686
39proline transport (GO:0015824)3.39569000
40neuronal action potential propagation (GO:0019227)3.37347795
41regulation of synaptic plasticity (GO:0048167)3.37069706
42dendritic spine organization (GO:0097061)3.37031574
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.33844564
44layer formation in cerebral cortex (GO:0021819)3.30354689
45neuronal ion channel clustering (GO:0045161)3.30312329
46regulation of heart rate by cardiac conduction (GO:0086091)3.29151444
47exploration behavior (GO:0035640)3.27834958
48cardiac conduction (GO:0061337)3.26337004
49negative regulation of dendrite morphogenesis (GO:0050774)3.22560332
50synaptic transmission, glutamatergic (GO:0035249)3.21860989
51neuromuscular process controlling balance (GO:0050885)3.21683869
52regulation of vesicle fusion (GO:0031338)3.19613988
53regulation of ARF protein signal transduction (GO:0032012)3.17696222
54positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.06470690
55protein localization to synapse (GO:0035418)3.05554228
56neuron cell-cell adhesion (GO:0007158)3.05381477
57regulation of neurotransmitter secretion (GO:0046928)3.04796549
58positive regulation of neurotransmitter transport (GO:0051590)3.03433184
59neuron-neuron synaptic transmission (GO:0007270)3.02874119
60regulation of excitatory postsynaptic membrane potential (GO:0060079)3.02674065
61regulation of glutamate receptor signaling pathway (GO:1900449)3.00428267
62response to histamine (GO:0034776)3.00181438
63neuromuscular process controlling posture (GO:0050884)3.00154234
64positive regulation of dendritic spine morphogenesis (GO:0061003)3.00057272
65positive regulation of dendritic spine development (GO:0060999)2.95473172
66glutamate receptor signaling pathway (GO:0007215)2.92460116
67NADH metabolic process (GO:0006734)2.92302579
68signal release (GO:0023061)2.90614249
69mating behavior (GO:0007617)2.89828927
70regulation of postsynaptic membrane potential (GO:0060078)2.88392121
71regulation of voltage-gated calcium channel activity (GO:1901385)2.87725469
72positive regulation of neurotransmitter secretion (GO:0001956)2.87549995
73regulation of synapse structural plasticity (GO:0051823)2.86418979
74neurotransmitter-gated ion channel clustering (GO:0072578)2.86327470
75membrane hyperpolarization (GO:0060081)2.84113374
76neurotransmitter uptake (GO:0001504)2.82850252
77negative regulation of microtubule polymerization (GO:0031115)2.82683426
78chemosensory behavior (GO:0007635)2.82580125
79synaptic vesicle transport (GO:0048489)2.81708030
80establishment of synaptic vesicle localization (GO:0097480)2.81708030
81membrane repolarization (GO:0086009)2.80730124
82axon ensheathment in central nervous system (GO:0032291)2.78973008
83central nervous system myelination (GO:0022010)2.78973008
84regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.78825118
85negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78457717
86regulation of neurotransmitter transport (GO:0051588)2.76837431
87cochlea development (GO:0090102)2.75246346
88peptidyl-tyrosine autophosphorylation (GO:0038083)2.75121819
89dicarboxylic acid transport (GO:0006835)2.74986988
90regulation of dendritic spine morphogenesis (GO:0061001)2.74616403
91auditory behavior (GO:0031223)2.73561249
92bundle of His cell to Purkinje myocyte communication (GO:0086069)2.72297239
93acid secretion (GO:0046717)2.71767359
94myelin maintenance (GO:0043217)2.68886003
95cerebellar Purkinje cell differentiation (GO:0021702)2.66496412
96long-term memory (GO:0007616)2.66096016
97adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.65108706
98dopamine receptor signaling pathway (GO:0007212)2.65094521
99regulation of water loss via skin (GO:0033561)2.64487482
100multicellular organismal signaling (GO:0035637)2.64367387

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.25369435
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.27334706
3RARB_27405468_Chip-Seq_BRAIN_Mouse2.97767230
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.93507837
5REST_21632747_ChIP-Seq_MESCs_Mouse2.84838752
6DROSHA_22980978_ChIP-Seq_HELA_Human2.48570084
7REST_18959480_ChIP-ChIP_MESCs_Mouse2.44075765
8ERG_21242973_ChIP-ChIP_JURKAT_Human2.38760008
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.38623930
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35637305
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.33457362
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32229365
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.29411512
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29250279
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21794354
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.20105771
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.15674598
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15184964
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14003234
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12743317
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10094183
22ZFP281_18757296_ChIP-ChIP_E14_Mouse2.10058120
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09330606
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09330606
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.01198386
26RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.97905476
27EZH2_22144423_ChIP-Seq_EOC_Human1.89509760
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.85816636
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85184367
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83620288
31RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.83560115
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.83042527
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80332921
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.78886518
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76091641
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.70466506
37TET1_21490601_ChIP-Seq_MESCs_Mouse1.68595915
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68232649
39CDX2_20551321_ChIP-Seq_CACO-2_Human1.67489327
40CTCF_27219007_Chip-Seq_Bcells_Human1.64228123
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.63770763
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.62879047
43KDM2B_26808549_Chip-Seq_K562_Human1.61385364
44LXR_22292898_ChIP-Seq_THP-1_Human1.61107748
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60748995
46RACK7_27058665_Chip-Seq_MCF-7_Human1.59992297
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59797475
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.52384372
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.47427672
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46047904
51ZNF263_19887448_ChIP-Seq_K562_Human1.45114387
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41608111
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39780187
54CREB1_26743006_Chip-Seq_LNCaP_Human1.37869358
55SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30007393
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27999755
57SMC4_20622854_ChIP-Seq_HELA_Human1.27839850
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.27368511
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27283095
60SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26171131
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25864108
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22871233
63BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.18615944
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.17792980
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.17327502
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17116731
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13677542
68GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.13112732
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.12174514
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09837248
71SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.09416324
72P68_20966046_ChIP-Seq_HELA_Human1.04964309
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04313255
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.02725110
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02075378
76SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01847481
77RUNX1_27514584_Chip-Seq_MCF-7_Human0.94827395
78BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94670074
79SA1_27219007_Chip-Seq_Bcells_Human0.93200544
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93054552
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90912465
82NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.90750651
83* TP63_22573176_ChIP-Seq_HFKS_Human0.90186629
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89965131
85OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88849128
86ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87449212
87EGR1_19032775_ChIP-ChIP_M12_Human0.85125532
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84655703
89NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84394154
90WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82930530
91OCT4_19829295_ChIP-Seq_ESCs_Human0.82679173
92SA1_27219007_Chip-Seq_ERYTHROID_Human0.82107363
93NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.81229268
94AR_19668381_ChIP-Seq_PC3_Human0.80671242
95JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.79710351
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79367311
97CTCF_20526341_ChIP-Seq_ESCs_Human0.78691033
98SOX2_20726797_ChIP-Seq_SW620_Human0.77600896
99MYC_19915707_ChIP-ChIP_AK7_Human0.76997862
100FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76749711

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.84063086
2MP0004270_analgesia4.78172170
3MP0010234_abnormal_vibrissa_follicle4.14676888
4MP0003880_abnormal_central_pattern4.06724015
5MP0003635_abnormal_synaptic_transmissio3.11286436
6MP0005423_abnormal_somatic_nervous2.95658729
7MP0002064_seizures2.95268082
8MP0000579_abnormal_nail_morphology2.79164601
9MP0002734_abnormal_mechanical_nocicepti2.67040284
10MP0009745_abnormal_behavioral_response2.64210171
11MP0002063_abnormal_learning/memory/cond2.45134143
12MP0009046_muscle_twitch2.38578847
13MP0009780_abnormal_chondrocyte_physiolo2.36256491
14MP0002796_impaired_skin_barrier2.35881556
15MP0002272_abnormal_nervous_system2.33531219
16MP0003879_abnormal_hair_cell2.31031378
17MP0001486_abnormal_startle_reflex2.11744959
18MP0003123_paternal_imprinting2.11255243
19MP0002572_abnormal_emotion/affect_behav2.08923534
20MP0003329_amyloid_beta_deposits1.98484747
21MP0008569_lethality_at_weaning1.97743771
22MP0001188_hyperpigmentation1.94155952
23MP0001968_abnormal_touch/_nociception1.93133377
24MP0003787_abnormal_imprinting1.90678972
25MP0000566_synostosis1.88817815
26MP0002822_catalepsy1.85493712
27MP0001501_abnormal_sleep_pattern1.82910336
28MP0002909_abnormal_adrenal_gland1.58623472
29MP0004885_abnormal_endolymph1.57652273
30MP0002736_abnormal_nociception_after1.54849820
31MP0004264_abnormal_extraembryonic_tissu1.53584696
32MP0001970_abnormal_pain_threshold1.50452686
33MP0005409_darkened_coat_color1.41335124
34MP0009379_abnormal_foot_pigmentation1.40301282
35MP0002733_abnormal_thermal_nociception1.39672536
36MP0001440_abnormal_grooming_behavior1.38410443
37MP0004147_increased_porphyrin_level1.36865631
38MP0002735_abnormal_chemical_nociception1.33288790
39MP0002557_abnormal_social/conspecific_i1.32693207
40MP0001346_abnormal_lacrimal_gland1.32357782
41MP0004811_abnormal_neuron_physiology1.29993821
42MP0005501_abnormal_skin_physiology1.25521200
43MP0002067_abnormal_sensory_capabilities1.23848766
44MP0002066_abnormal_motor_capabilities/c1.19452658
45MP0005646_abnormal_pituitary_gland1.16626511
46MP0002098_abnormal_vibrissa_morphology1.15018703
47MP0001502_abnormal_circadian_rhythm1.13995032
48MP0004043_abnormal_pH_regulation1.13366450
49MP0000537_abnormal_urethra_morphology1.12841954
50MP0001765_abnormal_ion_homeostasis1.12247521
51MP0005386_behavior/neurological_phenoty1.08459064
52MP0004924_abnormal_behavior1.08459064
53MP0002882_abnormal_neuron_morphology1.08312484
54MP0010678_abnormal_skin_adnexa1.06328865
55MP0004742_abnormal_vestibular_system1.05811572
56MP0002184_abnormal_innervation1.04972929
57MP0003941_abnormal_skin_development1.04877324
58MP0000678_abnormal_parathyroid_gland1.04067383
59MP0001485_abnormal_pinna_reflex1.03403980
60MP0000778_abnormal_nervous_system1.01724346
61MP0002229_neurodegeneration0.99099744
62MP0001177_atelectasis0.98707881
63MP0004782_abnormal_surfactant_physiolog0.97705858
64MP0001664_abnormal_digestion0.97607307
65MP0004019_abnormal_vitamin_homeostasis0.97517908
66MP0001905_abnormal_dopamine_level0.96623896
67MP0006276_abnormal_autonomic_nervous0.95607173
68MP0000955_abnormal_spinal_cord0.94784993
69MP0003633_abnormal_nervous_system0.91208008
70MP0001666_abnormal_nutrient_absorption0.89510799
71MP0003122_maternal_imprinting0.88181099
72MP0002069_abnormal_eating/drinking_beha0.84466267
73MP0003631_nervous_system_phenotype0.84345704
74MP0000462_abnormal_digestive_system0.82664522
75MP0000920_abnormal_myelination0.81814491
76MP0001984_abnormal_olfaction0.79774102
77MP0001529_abnormal_vocalization0.79748065
78MP0002152_abnormal_brain_morphology0.79065702
79MP0008872_abnormal_physiological_respon0.77784934
80MP0000467_abnormal_esophagus_morphology0.77512474
81MP0003690_abnormal_glial_cell0.76725592
82MP0003634_abnormal_glial_cell0.76219017
83MP0005535_abnormal_body_temperature0.76181873
84MP0009672_abnormal_birth_weight0.76105941
85MP0010771_integument_phenotype0.75428949
86MP0002638_abnormal_pupillary_reflex0.74044387
87MP0003632_abnormal_nervous_system0.71540162
88MP0005636_abnormal_mineral_homeostasis0.68151015
89MP0005645_abnormal_hypothalamus_physiol0.68123753
90MP0010352_gastrointestinal_tract_polyps0.67279185
91MP0002876_abnormal_thyroid_physiology0.67127753
92MP0000377_abnormal_hair_follicle0.64779061
93MP0001963_abnormal_hearing_physiology0.63867836
94MP0003705_abnormal_hypodermis_morpholog0.61857569
95MP0003283_abnormal_digestive_organ0.60737765
96MP0008874_decreased_physiological_sensi0.60188583
97MP0000427_abnormal_hair_cycle0.60108178
98MP0001348_abnormal_lacrimal_gland0.58855027
99MP0002249_abnormal_larynx_morphology0.57831311
100MP0003183_abnormal_peptide_metabolism0.57528296

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.84393310
2Focal motor seizures (HP:0011153)4.95042546
3Ankle clonus (HP:0011448)4.28931496
4Focal seizures (HP:0007359)4.20753980
5Action tremor (HP:0002345)3.78977511
6Epileptic encephalopathy (HP:0200134)3.71057392
7Supranuclear gaze palsy (HP:0000605)3.69826883
8Pili torti (HP:0003777)3.66095915
9Febrile seizures (HP:0002373)3.55568981
10Limb dystonia (HP:0002451)3.29598910
11Atonic seizures (HP:0010819)3.28771395
12Akinesia (HP:0002304)3.21788862
13Generalized tonic-clonic seizures (HP:0002069)3.11506853
14Abnormality of nail color (HP:0100643)3.08126768
15Cerebral hypomyelination (HP:0006808)3.01883709
16Visual hallucinations (HP:0002367)2.97304920
17Neurofibrillary tangles (HP:0002185)2.88103212
18Right ventricular cardiomyopathy (HP:0011663)2.85884511
19Spastic gait (HP:0002064)2.74310852
20Abnormal eating behavior (HP:0100738)2.74274364
21Tetraplegia (HP:0002445)2.73089361
22Hyperactive renin-angiotensin system (HP:0000841)2.70175378
23Impaired vibration sensation in the lower limbs (HP:0002166)2.69645966
24Dysmetria (HP:0001310)2.66083440
25Intention tremor (HP:0002080)2.65692268
26Depression (HP:0000716)2.60391688
27Cerebral inclusion bodies (HP:0100314)2.53263443
28Absence seizures (HP:0002121)2.53251265
29Status epilepticus (HP:0002133)2.52119421
30Abnormal hair laboratory examination (HP:0003328)2.51881426
31Progressive cerebellar ataxia (HP:0002073)2.51620893
32Torticollis (HP:0000473)2.50434914
33Abnormality of binocular vision (HP:0011514)2.48449363
34Diplopia (HP:0000651)2.48449363
35Epileptiform EEG discharges (HP:0011182)2.48186348
36Dialeptic seizures (HP:0011146)2.40962378
37Ventricular fibrillation (HP:0001663)2.35100892
38Anxiety (HP:0000739)2.34983977
39Hyperparathyroidism (HP:0000843)2.34553756
40Postural instability (HP:0002172)2.33279712
41Abnormality of renin-angiotensin system (HP:0000847)2.32997235
42Plantar hyperkeratosis (HP:0007556)2.32697904
43Neuronal loss in central nervous system (HP:0002529)2.32411408
44Palmoplantar hyperkeratosis (HP:0000972)2.31885146
45Metabolic alkalosis (HP:0200114)2.31781253
46Confusion (HP:0001289)2.30529307
47Obstructive sleep apnea (HP:0002870)2.30064681
48Mutism (HP:0002300)2.29246847
49Truncal ataxia (HP:0002078)2.28499031
50Urinary urgency (HP:0000012)2.28224937
51Clonus (HP:0002169)2.27031127
52EEG with generalized epileptiform discharges (HP:0011198)2.26262886
53Sleep apnea (HP:0010535)2.24637195
54Urinary bladder sphincter dysfunction (HP:0002839)2.23959120
55Delusions (HP:0000746)2.22575766
56Abnormality of the corticospinal tract (HP:0002492)2.21501183
57Focal dystonia (HP:0004373)2.20915327
58Neonatal onset (HP:0003623)2.18765098
59Septate vagina (HP:0001153)2.17864079
60Annular pancreas (HP:0001734)2.16721355
61Syncope (HP:0001279)2.14581473
62Hypsarrhythmia (HP:0002521)2.13679638
63Palmar hyperkeratosis (HP:0010765)2.12878030
64Spastic tetraparesis (HP:0001285)2.09913199
65Abnormality of the salivary glands (HP:0010286)2.08941623
66Apathy (HP:0000741)2.07808737
67Bradykinesia (HP:0002067)2.06522350
68Diminished movement (HP:0002374)2.02266294
69Choreoathetosis (HP:0001266)2.02039053
70Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.01689851
71Hyperaldosteronism (HP:0000859)1.97894041
72Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95913160
73CNS hypomyelination (HP:0003429)1.93961871
74Hyperphosphatemia (HP:0002905)1.92720842
75Impaired social interactions (HP:0000735)1.92266136
76Abnormal social behavior (HP:0012433)1.92266136
77Craniofacial dystonia (HP:0012179)1.91956264
78Rigidity (HP:0002063)1.91778722
79Bundle branch block (HP:0011710)1.89536380
80Poor eye contact (HP:0000817)1.88959335
81Abnormality of the lower motor neuron (HP:0002366)1.87396899
82Dysmetric saccades (HP:0000641)1.87303447
83Diminished motivation (HP:0000745)1.84703807
84Decreased circulating renin level (HP:0003351)1.84153591
85Impaired vibratory sensation (HP:0002495)1.83869373
86Hyperinsulinemic hypoglycemia (HP:0000825)1.83341050
87Impaired smooth pursuit (HP:0007772)1.83142575
88Polyphagia (HP:0002591)1.82711956
89Congenital ichthyosiform erythroderma (HP:0007431)1.81110962
90Fragile nails (HP:0001808)1.80325898
91Dysdiadochokinesis (HP:0002075)1.78457418
92Lower limb muscle weakness (HP:0007340)1.76970273
93Degeneration of the lateral corticospinal tracts (HP:0002314)1.76843229
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76843229
95Insomnia (HP:0100785)1.76666033
96Hypoglycemic coma (HP:0001325)1.76312161
97Onycholysis (HP:0001806)1.74893653
98Gout (HP:0001997)1.73740821
99Hypoglycemic seizures (HP:0002173)1.71341489
100Symptomatic seizures (HP:0011145)1.70137958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.14438358
2MAP3K93.32200913
3NTRK33.18001991
4DAPK23.07030104
5RIPK12.73298932
6MARK12.70211612
7PAK62.69794312
8MINK12.45245743
9UHMK12.41674163
10MST1R2.10097828
11MAP3K122.06489943
12CAMKK12.02045094
13PRKD31.96655029
14CASK1.96621740
15EPHA21.93017799
16ARAF1.66354760
17NTRK11.61386869
18NTRK21.60625034
19LATS21.60408687
20PHKG11.58638896
21PHKG21.58638896
22DAPK11.55094972
23TRIB31.48717645
24GRK51.38635560
25TESK11.36942003
26KSR21.32576126
27CDK51.29038383
28CAMK2B1.23516984
29LMTK21.22882431
30ALK1.22164639
31NEK61.21841831
32CDK191.20213740
33MAP3K21.19300558
34BRSK11.14194551
35CDK151.13834214
36OXSR11.13087869
37CDK181.11941066
38FGFR21.04387198
39CDK11A1.04065339
40SGK2230.99430062
41SGK4940.99430062
42CDK140.99058426
43PAK30.98946497
44CAMK2G0.97574082
45PRKG20.96363458
46PLK20.93969298
47PRKCH0.93519091
48PRKCG0.93332866
49PINK10.92706048
50CDK120.90604418
51EEF2K0.86528347
52MAP2K60.80881697
53FER0.80878911
54CAMK10.79311347
55PRKCI0.78757081
56TSSK60.78369317
57CAMK2D0.77296997
58CAMK2A0.76782423
59PRPF4B0.76250169
60NME10.75899031
61MET0.74936776
62PDPK10.72991407
63BRAF0.69024482
64MAPK130.68587875
65DYRK1A0.68503910
66PIK3CA0.68217022
67SMG10.67876716
68LIMK10.65498401
69STK110.65194958
70TYRO30.63382119
71CSNK1G20.62538988
72STK380.61613737
73STK390.61093569
74CSNK1E0.60728622
75ICK0.60537967
76SGK10.60268856
77MAPKAPK30.59914390
78PTK20.58358041
79PDK10.56125663
80CAMKK20.55458808
81PRKCZ0.55344554
82MAP3K110.54977199
83MAP2K40.53252890
84MAP3K10.52161351
85SGK30.51890956
86TAOK10.51584656
87ERBB20.51336038
88MARK20.51131178
89DAPK30.50300839
90CSNK1G30.49386551
91KSR10.48396611
92MAP3K40.47567901
93WNK10.46265261
94MAPK100.45704389
95CSNK1A10.45433252
96SCYL20.42437834
97SGK20.41406980
98RPS6KA30.39784877
99PRKCA0.37817384
100MAP2K70.36556292

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.74568549
2Nicotine addiction_Homo sapiens_hsa050333.20646157
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.15616795
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.76196207
5Amphetamine addiction_Homo sapiens_hsa050312.34482554
6Insulin secretion_Homo sapiens_hsa049112.27222667
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.22420094
8Long-term potentiation_Homo sapiens_hsa047202.17815168
9Vitamin B6 metabolism_Homo sapiens_hsa007502.13495849
10GABAergic synapse_Homo sapiens_hsa047271.94732594
11Glutamatergic synapse_Homo sapiens_hsa047241.91690194
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87746305
13Circadian entrainment_Homo sapiens_hsa047131.84400162
14Dopaminergic synapse_Homo sapiens_hsa047281.78742608
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77260168
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.74139322
17Arginine biosynthesis_Homo sapiens_hsa002201.73623586
18Cocaine addiction_Homo sapiens_hsa050301.68521458
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68044431
20Gastric acid secretion_Homo sapiens_hsa049711.63378443
21Morphine addiction_Homo sapiens_hsa050321.55173249
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47971452
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45555910
24Vibrio cholerae infection_Homo sapiens_hsa051101.42517580
25Histidine metabolism_Homo sapiens_hsa003401.38500122
26Mineral absorption_Homo sapiens_hsa049781.35614224
27Salivary secretion_Homo sapiens_hsa049701.34121795
28Collecting duct acid secretion_Homo sapiens_hsa049661.33981713
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28175979
30Pancreatic secretion_Homo sapiens_hsa049721.25754487
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24393913
32* Arginine and proline metabolism_Homo sapiens_hsa003301.23762934
33Renin secretion_Homo sapiens_hsa049241.22738233
34Bile secretion_Homo sapiens_hsa049761.21411072
35Sulfur metabolism_Homo sapiens_hsa009201.20034821
36Cholinergic synapse_Homo sapiens_hsa047251.16208576
37GnRH signaling pathway_Homo sapiens_hsa049121.06756060
38Long-term depression_Homo sapiens_hsa047301.02466442
39Taste transduction_Homo sapiens_hsa047421.01954220
40Thyroid hormone synthesis_Homo sapiens_hsa049181.01221182
41Phenylalanine metabolism_Homo sapiens_hsa003601.00685278
42Serotonergic synapse_Homo sapiens_hsa047261.00298940
43Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97442496
44Cardiac muscle contraction_Homo sapiens_hsa042600.95768676
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95183652
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93234117
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89216535
48Oocyte meiosis_Homo sapiens_hsa041140.88992797
49Estrogen signaling pathway_Homo sapiens_hsa049150.88223347
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84627128
51Fructose and mannose metabolism_Homo sapiens_hsa000510.84044655
52cAMP signaling pathway_Homo sapiens_hsa040240.83410018
53Calcium signaling pathway_Homo sapiens_hsa040200.82532134
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82306299
55Glucagon signaling pathway_Homo sapiens_hsa049220.81124742
56Fatty acid biosynthesis_Homo sapiens_hsa000610.79694187
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79447853
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78899140
59Oxytocin signaling pathway_Homo sapiens_hsa049210.77762854
60Alzheimers disease_Homo sapiens_hsa050100.77125317
61Gap junction_Homo sapiens_hsa045400.76175338
62Fat digestion and absorption_Homo sapiens_hsa049750.74654757
63Fatty acid elongation_Homo sapiens_hsa000620.71362163
64Biosynthesis of amino acids_Homo sapiens_hsa012300.70408964
65Folate biosynthesis_Homo sapiens_hsa007900.70111586
66Oxidative phosphorylation_Homo sapiens_hsa001900.69016919
67Tight junction_Homo sapiens_hsa045300.67354433
68Melanogenesis_Homo sapiens_hsa049160.66678890
69Pyruvate metabolism_Homo sapiens_hsa006200.64566016
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.62913402
71Vitamin digestion and absorption_Homo sapiens_hsa049770.62355055
72beta-Alanine metabolism_Homo sapiens_hsa004100.58639899
73ErbB signaling pathway_Homo sapiens_hsa040120.58206232
74Carbon metabolism_Homo sapiens_hsa012000.58159521
75Inositol phosphate metabolism_Homo sapiens_hsa005620.57730045
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56928217
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54317045
78Nitrogen metabolism_Homo sapiens_hsa009100.53603737
79Fatty acid metabolism_Homo sapiens_hsa012120.51103007
80Glioma_Homo sapiens_hsa052140.49112924
81Type II diabetes mellitus_Homo sapiens_hsa049300.48195796
82Axon guidance_Homo sapiens_hsa043600.46764688
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46132568
84Renin-angiotensin system_Homo sapiens_hsa046140.45388111
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45331303
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45203314
87Ovarian steroidogenesis_Homo sapiens_hsa049130.42486981
88Parkinsons disease_Homo sapiens_hsa050120.41502447
89Galactose metabolism_Homo sapiens_hsa000520.39981188
90Sulfur relay system_Homo sapiens_hsa041220.39068068
91VEGF signaling pathway_Homo sapiens_hsa043700.38634420
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38620122
93Protein digestion and absorption_Homo sapiens_hsa049740.38060173
94AMPK signaling pathway_Homo sapiens_hsa041520.37504388
95Sphingolipid metabolism_Homo sapiens_hsa006000.37212902
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36332932
97Olfactory transduction_Homo sapiens_hsa047400.36171244
98Prion diseases_Homo sapiens_hsa050200.34034405
99Ether lipid metabolism_Homo sapiens_hsa005650.33924550
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.30365985

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