CKS1BP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.79887228
2DNA unwinding involved in DNA replication (GO:0006268)6.09768031
3nuclear pore organization (GO:0006999)5.49848510
4mitotic chromosome condensation (GO:0007076)5.40012975
5establishment of integrated proviral latency (GO:0075713)5.33425275
6pore complex assembly (GO:0046931)5.27617167
7mitotic sister chromatid segregation (GO:0000070)5.24986583
8protein localization to chromosome, centromeric region (GO:0071459)5.13671130
9sister chromatid segregation (GO:0000819)5.04949867
10protein localization to kinetochore (GO:0034501)5.03743707
11mitotic metaphase plate congression (GO:0007080)4.95287161
12DNA replication initiation (GO:0006270)4.55435094
13DNA strand elongation involved in DNA replication (GO:0006271)4.50438032
14DNA strand elongation (GO:0022616)4.45670405
15DNA topological change (GO:0006265)4.43764048
16regulation of mitotic spindle organization (GO:0060236)4.39243452
17formation of translation preinitiation complex (GO:0001731)4.38586968
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.21777872
19metaphase plate congression (GO:0051310)4.11332823
20establishment of viral latency (GO:0019043)4.08819798
21telomere maintenance via semi-conservative replication (GO:0032201)4.08187877
22mitotic nuclear envelope disassembly (GO:0007077)3.76583109
23chromosome condensation (GO:0030261)3.75779163
24telomere maintenance via recombination (GO:0000722)3.71753206
25regulation of spindle organization (GO:0090224)3.69211910
26mitotic recombination (GO:0006312)3.66482349
27mitotic sister chromatid cohesion (GO:0007064)3.66014854
28histone H2B ubiquitination (GO:0033523)3.65190529
29heterochromatin organization (GO:0070828)3.60111582
30nuclear envelope disassembly (GO:0051081)3.55171887
31membrane disassembly (GO:0030397)3.55171887
32ribosomal small subunit assembly (GO:0000028)3.52842545
33DNA replication checkpoint (GO:0000076)3.50608955
34ribosomal small subunit biogenesis (GO:0042274)3.46825505
35establishment of chromosome localization (GO:0051303)3.45903325
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.42522574
37regulation of translational termination (GO:0006449)3.41073502
38DNA packaging (GO:0006323)3.37413850
39meiotic chromosome segregation (GO:0045132)3.35630781
40protein localization to chromosome (GO:0034502)3.34440876
41CENP-A containing nucleosome assembly (GO:0034080)3.32215200
42regulation of double-strand break repair (GO:2000779)3.30449737
43ribosome assembly (GO:0042255)3.30419451
44DNA duplex unwinding (GO:0032508)3.29288037
45positive regulation of DNA-templated transcription, elongation (GO:0032786)3.28558451
46DNA synthesis involved in DNA repair (GO:0000731)3.28209656
47chromosome segregation (GO:0007059)3.27359437
48viral mRNA export from host cell nucleus (GO:0046784)3.27113431
49regulation of chromosome segregation (GO:0051983)3.26266037
50kinetochore organization (GO:0051383)3.25207250
51regulation of RNA export from nucleus (GO:0046831)3.24688917
52DNA conformation change (GO:0071103)3.24116655
53negative regulation of DNA repair (GO:0045738)3.21877475
54regulation of translational fidelity (GO:0006450)3.21001914
55ribosomal large subunit biogenesis (GO:0042273)3.20375361
56regulation of double-strand break repair via homologous recombination (GO:0010569)3.20104708
57chromatin assembly or disassembly (GO:0006333)3.14597541
58DNA geometric change (GO:0032392)3.11989690
59mitotic cytokinesis (GO:0000281)3.09707134
60chromatin remodeling at centromere (GO:0031055)3.06840552
61regulation of histone H3-K4 methylation (GO:0051569)3.06507172
62negative regulation of chromosome segregation (GO:0051985)3.04874847
63positive regulation of chromosome segregation (GO:0051984)3.03958708
64ATP-dependent chromatin remodeling (GO:0043044)3.03421568
65regulation of sister chromatid cohesion (GO:0007063)3.02998935
66spindle checkpoint (GO:0031577)3.02622647
67peptidyl-arginine omega-N-methylation (GO:0035247)2.99835275
68regulation of centriole replication (GO:0046599)2.98532032
69negative regulation of mitotic sister chromatid separation (GO:2000816)2.96703471
70negative regulation of sister chromatid segregation (GO:0033046)2.96703471
71negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96703471
72negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96703471
73negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96703471
74ribonucleoprotein complex biogenesis (GO:0022613)2.96632253
75positive regulation of DNA-dependent DNA replication (GO:2000105)2.96527793
76regulation of centrosome cycle (GO:0046605)2.95217059
77mitotic spindle assembly checkpoint (GO:0007094)2.93277807
78folic acid-containing compound biosynthetic process (GO:0009396)2.93007288
79telomere maintenance via telomere lengthening (GO:0010833)2.91424924
80protein export from nucleus (GO:0006611)2.88734840
81spindle assembly checkpoint (GO:0071173)2.88104353
82DNA replication-independent nucleosome assembly (GO:0006336)2.87130418
83DNA replication-independent nucleosome organization (GO:0034724)2.87130418
84negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.85757867
85regulation of mitotic sister chromatid separation (GO:0010965)2.85365473
86regulation of mitotic sister chromatid segregation (GO:0033047)2.85365473
87regulation of sister chromatid segregation (GO:0033045)2.85365473
88protein maturation by protein folding (GO:0022417)2.84518178
89mitotic spindle checkpoint (GO:0071174)2.84078069
90mitotic G2/M transition checkpoint (GO:0044818)2.82288770
91spliceosomal tri-snRNP complex assembly (GO:0000244)2.81926538
92purine nucleobase biosynthetic process (GO:0009113)2.79178980
93positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.78660503
94ribosome biogenesis (GO:0042254)2.77608299
95nucleobase-containing small molecule interconversion (GO:0015949)2.77427770
96regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.75889284
97regulation of mitotic metaphase/anaphase transition (GO:0030071)2.75889284
98nucleotide-excision repair, DNA gap filling (GO:0006297)2.72838840
99chromatin assembly (GO:0031497)2.71722281
100non-recombinational repair (GO:0000726)2.69130624

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.12412279
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.59267377
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.92472192
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.86123358
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.80920114
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.59826960
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.39122227
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.25817507
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.08474123
10AR_21909140_ChIP-Seq_LNCAP_Human2.69723848
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64836672
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56656027
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54579851
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46903298
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43664182
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.35113162
17XRN2_22483619_ChIP-Seq_HELA_Human2.32946928
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20816798
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.15562619
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.10158180
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.03966162
22DCP1A_22483619_ChIP-Seq_HELA_Human2.02233109
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00006038
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92303043
25MYC_22102868_ChIP-Seq_BL_Human1.91816676
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.86551668
27ZFX_18555785_ChIP-Seq_MESCs_Mouse1.85449581
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81863683
29TTF2_22483619_ChIP-Seq_HELA_Human1.81270333
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78918796
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73926043
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72860552
33ZNF263_19887448_ChIP-Seq_K562_Human1.71912926
34CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.71027174
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66795021
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66311504
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.65989477
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.65966266
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.63656583
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63462316
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62268474
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.60175091
43KDM5A_27292631_Chip-Seq_BREAST_Human1.59001618
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57293164
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51326755
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51172110
47GABP_19822575_ChIP-Seq_HepG2_Human1.50389697
48ELK1_19687146_ChIP-ChIP_HELA_Human1.48259649
49KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45412760
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44740714
51FOXP3_21729870_ChIP-Seq_TREG_Human1.43208322
52CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.42627116
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37049521
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32608139
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32154796
56CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31923992
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30647762
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30431046
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29934738
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26974082
61CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21033462
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16157669
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15978416
64CIITA_25753668_ChIP-Seq_RAJI_Human1.15710396
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.15480150
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15310859
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12545742
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12133388
69VDR_23849224_ChIP-Seq_CD4+_Human1.08919327
70NCOR1_26117541_ChIP-Seq_K562_Human1.08326499
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07706538
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05374691
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04465717
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02810793
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02296257
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.01431718
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.01168961
78SOX17_20123909_ChIP-Seq_XEN_Mouse0.98815836
79CHD1_26751641_Chip-Seq_LNCaP_Human0.98339467
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97684238
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96138613
82ELK3_25401928_ChIP-Seq_HUVEC_Human0.94550051
83PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94457988
84VDR_21846776_ChIP-Seq_THP-1_Human0.94213017
85TFEB_21752829_ChIP-Seq_HELA_Human0.92370100
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91985279
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89612961
88SALL1_21062744_ChIP-ChIP_HESCs_Human0.88810102
89SRF_21415370_ChIP-Seq_HL-1_Mouse0.87680936
90TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85487958
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85074319
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84465886
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.84320180
94NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.81997520
95P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81996246
96TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81243767
97ATF3_27146783_Chip-Seq_COLON_Human0.81071861
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80997043
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80978894
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80881929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.96096587
2MP0010094_abnormal_chromosome_stability4.56595114
3MP0003693_abnormal_embryo_hatching4.43107108
4MP0004957_abnormal_blastocyst_morpholog3.80669892
5MP0003111_abnormal_nucleus_morphology3.78324384
6MP0008058_abnormal_DNA_repair3.48540753
7MP0003077_abnormal_cell_cycle3.15327716
8MP0008007_abnormal_cellular_replicative2.94076654
9MP0008932_abnormal_embryonic_tissue2.85309143
10MP0009697_abnormal_copulation2.83311420
11MP0004185_abnormal_adipocyte_glucose2.80508084
12MP0001730_embryonic_growth_arrest2.51829559
13MP0004233_abnormal_muscle_weight2.50438304
14MP0003705_abnormal_hypodermis_morpholog2.21363668
15MP0003786_premature_aging2.20121456
16MP0000350_abnormal_cell_proliferation2.17212395
17MP0010307_abnormal_tumor_latency2.05748638
18MP0005076_abnormal_cell_differentiation1.98019800
19MP0002396_abnormal_hematopoietic_system1.94937875
20MP0002877_abnormal_melanocyte_morpholog1.85422456
21MP0005451_abnormal_body_composition1.83827902
22MP0001697_abnormal_embryo_size1.81411887
23MP0003656_abnormal_erythrocyte_physiolo1.75637538
24MP0005380_embryogenesis_phenotype1.75035578
25MP0001672_abnormal_embryogenesis/_devel1.75035578
26MP0003984_embryonic_growth_retardation1.68435637
27MP0002080_prenatal_lethality1.66645801
28MP0010352_gastrointestinal_tract_polyps1.65601765
29MP0000678_abnormal_parathyroid_gland1.63278134
30MP0002088_abnormal_embryonic_growth/wei1.58246520
31MP0002085_abnormal_embryonic_tissue1.48280083
32MP0001727_abnormal_embryo_implantation1.47385341
33MP0000313_abnormal_cell_death1.43972514
34MP0003566_abnormal_cell_adhesion1.37485040
35MP0000537_abnormal_urethra_morphology1.36833555
36MP0002084_abnormal_developmental_patter1.36062003
37MP0005501_abnormal_skin_physiology1.33970253
38MP0003718_maternal_effect1.32521583
39MP0009333_abnormal_splenocyte_physiolog1.30331725
40MP0002086_abnormal_extraembryonic_tissu1.29948164
41MP0005623_abnormal_meninges_morphology1.27810831
42MP0002019_abnormal_tumor_incidence1.25117189
43MP0008995_early_reproductive_senescence1.24106701
44MP0000358_abnormal_cell_content/1.19806997
45MP0010030_abnormal_orbit_morphology1.19782388
46MP0002210_abnormal_sex_determination1.14116451
47MP0008438_abnormal_cutaneous_collagen1.13162242
48MP0009672_abnormal_birth_weight1.08220260
49MP0004197_abnormal_fetal_growth/weight/1.06910611
50MP0002269_muscular_atrophy1.01464337
51MP0003315_abnormal_perineum_morphology1.00455478
52MP0006035_abnormal_mitochondrial_morpho0.98296891
53MP0001873_stomach_inflammation0.96690067
54MP0001915_intracranial_hemorrhage0.96469325
55MP0004808_abnormal_hematopoietic_stem0.95341655
56MP0005621_abnormal_cell_physiology0.93564277
57MP0003950_abnormal_plasma_membrane0.91588406
58MP0003937_abnormal_limbs/digits/tail_de0.91574558
59MP0000490_abnormal_crypts_of0.91547477
60MP0005384_cellular_phenotype0.89516825
61MP0000858_altered_metastatic_potential0.87687489
62MP0003890_abnormal_embryonic-extraembry0.87586820
63MP0000428_abnormal_craniofacial_morphol0.87338108
64MP0000627_abnormal_mammary_gland0.86337004
65MP0001145_abnormal_male_reproductive0.86037503
66MP0001661_extended_life_span0.85090268
67MP0001881_abnormal_mammary_gland0.84637507
68MP0003385_abnormal_body_wall0.84295785
69MP0003453_abnormal_keratinocyte_physiol0.82318212
70MP0001929_abnormal_gametogenesis0.81655567
71MP0004134_abnormal_chest_morphology0.81400668
72MP0002092_abnormal_eye_morphology0.78780016
73MP0003942_abnormal_urinary_system0.78427859
74MP0003943_abnormal_hepatobiliary_system0.75385435
75MP0002234_abnormal_pharynx_morphology0.75261885
76MP0002970_abnormal_white_adipose0.75074535
77MP0002697_abnormal_eye_size0.74589024
78MP0000467_abnormal_esophagus_morphology0.73548800
79MP0002006_tumorigenesis0.73053862
80MP0008877_abnormal_DNA_methylation0.72474783
81MP0003221_abnormal_cardiomyocyte_apopto0.71281477
82MP0000653_abnormal_sex_gland0.71222055
83MP0001286_abnormal_eye_development0.69260276
84MP0001243_abnormal_dermal_layer0.68895443
85MP0000703_abnormal_thymus_morphology0.68752942
86MP0003935_abnormal_craniofacial_develop0.68685422
87MP0005666_abnormal_adipose_tissue0.68262551
88MP0003186_abnormal_redox_activity0.67408611
89MP0003699_abnormal_female_reproductive0.67201645
90MP0002111_abnormal_tail_morphology0.66574613
91MP0000733_abnormal_muscle_development0.66158065
92MP0009703_decreased_birth_body0.66034662
93MP0003806_abnormal_nucleotide_metabolis0.64855894
94MP0002060_abnormal_skin_morphology0.64435482
95MP0003123_paternal_imprinting0.62844695
96MP0005408_hypopigmentation0.62374005
97MP0010630_abnormal_cardiac_muscle0.62343548
98MP0000759_abnormal_skeletal_muscle0.61445367
99MP0008961_abnormal_basal_metabolism0.60862065
100MP0002114_abnormal_axial_skeleton0.60833385

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.89836582
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.56227564
3Cholecystitis (HP:0001082)3.58774280
4Abnormal gallbladder physiology (HP:0012438)3.58774280
5Abnormality of cells of the erythroid lineage (HP:0012130)3.54692008
6Nephroblastoma (Wilms tumor) (HP:0002667)3.23883698
7Increased nuchal translucency (HP:0010880)3.22491432
8Orthostatic hypotension (HP:0001278)3.04740127
9Embryonal renal neoplasm (HP:0011794)3.01788412
10Abnormality of chromosome stability (HP:0003220)2.88461026
11Reticulocytopenia (HP:0001896)2.76480398
12Termporal pattern (HP:0011008)2.74212628
13Insidious onset (HP:0003587)2.74212628
14Cortical dysplasia (HP:0002539)2.73069939
15Abnormality of the preputium (HP:0100587)2.70186733
16Ankyloglossia (HP:0010296)2.62059328
17Protrusio acetabuli (HP:0003179)2.60805845
18Myelodysplasia (HP:0002863)2.56184642
19Deep philtrum (HP:0002002)2.55080761
20Progressive muscle weakness (HP:0003323)2.53956374
21Abnormality of reticulocytes (HP:0004312)2.52904995
22Abnormal number of erythroid precursors (HP:0012131)2.50727322
23Overlapping toe (HP:0001845)2.48819250
24Upper limb muscle weakness (HP:0003484)2.45693068
25Reticulocytosis (HP:0001923)2.41737698
26Selective tooth agenesis (HP:0001592)2.40361280
27Aplastic anemia (HP:0001915)2.39727039
28Meckel diverticulum (HP:0002245)2.38721767
29Vertebral compression fractures (HP:0002953)2.38655751
30Hand muscle atrophy (HP:0009130)2.38161711
31Heterotopia (HP:0002282)2.37339071
32Deviation of the thumb (HP:0009603)2.36119675
33Proximal placement of thumb (HP:0009623)2.34856835
34Asymmetry of the thorax (HP:0001555)2.34394559
35Abnormality of the ileum (HP:0001549)2.33342302
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.29083473
37Trismus (HP:0000211)2.28567093
38Small intestinal stenosis (HP:0012848)2.28306618
39Duodenal stenosis (HP:0100867)2.28306618
40Birth length less than 3rd percentile (HP:0003561)2.23680512
41Cafe-au-lait spot (HP:0000957)2.23424983
42Insomnia (HP:0100785)2.18544023
43Abnormality of oral frenula (HP:0000190)2.17287822
44Hyperacusis (HP:0010780)2.15670211
45Abnormal umbilical cord blood vessels (HP:0011403)2.13876748
46Single umbilical artery (HP:0001195)2.13876748
47Abnormality of the fetal cardiovascular system (HP:0010948)2.13876748
48Sparse lateral eyebrow (HP:0005338)2.12588830
49Distal upper limb amyotrophy (HP:0007149)2.08370446
50Upper limb amyotrophy (HP:0009129)2.08370446
51Macrocytic anemia (HP:0001972)2.06763759
52Abnormality of glycolysis (HP:0004366)2.02981339
53Abnormality of the carotid arteries (HP:0005344)2.02623927
54Multiple enchondromatosis (HP:0005701)2.00073921
55Rough bone trabeculation (HP:0100670)1.98784240
56Entropion (HP:0000621)1.97906558
57Microvesicular hepatic steatosis (HP:0001414)1.96764597
58Hypoplastic left heart (HP:0004383)1.95984223
59Poikiloderma (HP:0001029)1.94693400
60Biconcave vertebral bodies (HP:0004586)1.94406982
61Volvulus (HP:0002580)1.92042502
62Renal duplication (HP:0000075)1.91841834
63Abnormal lung lobation (HP:0002101)1.90010749
64Increased serum pyruvate (HP:0003542)1.88132673
65Achilles tendon contracture (HP:0001771)1.88079088
66Pallor (HP:0000980)1.87230738
67Abnormality of the umbilical cord (HP:0010881)1.84971109
68Breech presentation (HP:0001623)1.83393375
69Horseshoe kidney (HP:0000085)1.82812415
70Septate vagina (HP:0001153)1.82714839
71Patellar dislocation (HP:0002999)1.81356770
72Long eyelashes (HP:0000527)1.79880020
73Hypoparathyroidism (HP:0000829)1.79270323
74Absent thumb (HP:0009777)1.74440200
75Premature rupture of membranes (HP:0001788)1.73798185
76Arteriovenous malformation (HP:0100026)1.72942481
77Diaphragmatic weakness (HP:0009113)1.72347392
78Unilateral renal agenesis (HP:0000122)1.72342867
79Limited elbow extension (HP:0001377)1.72293128
80Nonimmune hydrops fetalis (HP:0001790)1.72161685
81Choanal atresia (HP:0000453)1.71594095
82Abnormality of the tricuspid valve (HP:0001702)1.70000808
83Atresia of the external auditory canal (HP:0000413)1.69617500
84Elfin facies (HP:0004428)1.69451667
85Embryonal neoplasm (HP:0002898)1.69002252
86Missing ribs (HP:0000921)1.68206814
87Abnormality of the acetabulum (HP:0003170)1.67935041
88Disproportionate tall stature (HP:0001519)1.64839653
89Abnormality of the duodenum (HP:0002246)1.63949130
90Flat cornea (HP:0007720)1.63867716
91Duplication of thumb phalanx (HP:0009942)1.61235804
92Neoplasm of the pancreas (HP:0002894)1.60716201
93Thrombocytosis (HP:0001894)1.59929060
94Acute myeloid leukemia (HP:0004808)1.59163984
95Osteolytic defects of the phalanges of the hand (HP:0009771)1.58933430
96Osteolytic defects of the hand bones (HP:0009699)1.58933430
97Degeneration of anterior horn cells (HP:0002398)1.58780732
98Abnormality of the anterior horn cell (HP:0006802)1.58780732
9911 pairs of ribs (HP:0000878)1.57899018
100Male infertility (HP:0003251)1.57848743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.51502985
2CDC73.80521105
3CDK123.57559796
4TTK3.34382918
5EIF2AK13.29438698
6VRK23.15695896
7BUB12.76945727
8PBK2.65164198
9EEF2K2.17975684
10SRPK12.08893158
11ICK1.92946929
12LATS21.88898133
13SMG11.87900456
14NEK21.87159231
15TSSK61.71546679
16KDR1.62153105
17ILK1.61097123
18NME21.58954666
19TAF11.57253520
20RPS6KB21.56641207
21BRSK21.56137024
22BRSK11.52479917
23TESK11.52475928
24NEK11.49739631
25IRAK31.49578022
26CDK81.47456606
27WEE11.46878312
28SCYL21.44475075
29TESK21.42960880
30PLK41.42595183
31CHEK21.35610152
32MST1R1.33549809
33DMPK1.28744644
34BRD41.26944078
35CDK71.26319779
36DYRK31.25327754
37CDK41.24164649
38AURKB1.24100839
39MAP3K101.23884758
40PLK11.19877016
41ATR1.19463249
42PAK41.18211068
43CHEK11.13297303
44CLK11.12872828
45CDK91.07609634
46BMPR21.04828417
47MAP3K81.02589055
48PLK30.97356128
49AURKA0.97341718
50PTK20.94076637
51EIF2AK30.92573368
52SIK10.91602502
53PRPF4B0.88005700
54MTOR0.86510638
55BRAF0.86411922
56PAK20.84962586
57MET0.81661353
58TAOK20.81342758
59STK100.79910896
60STK40.79352379
61FGFR40.79021713
62PAK10.78205964
63ERBB40.77934481
64BMX0.77164048
65MELK0.76199286
66VRK10.74803744
67CDK10.72800429
68ATM0.71391716
69CDK20.67850879
70RPS6KA40.66711238
71KSR10.65851318
72PDGFRA0.65846293
73PNCK0.59933931
74CDK11A0.58615124
75MARK30.52151606
76LIMK10.52115339
77LRRK20.51527621
78RAF10.51400145
79CSNK2A20.50566207
80MAPKAPK50.49502210
81CDK150.48587320
82CSNK1E0.45136955
83EIF2AK20.44324135
84PTK60.44284887
85CDK180.43442033
86EPHB10.41992279
87AKT20.39806704
88LATS10.39751765
89PKN20.38805770
90SIK20.38427657
91PDK20.38243774
92CDK140.37116092
93PRKCI0.36827245
94STK160.36595736
95MAP3K20.35508798
96CCNB10.34416284
97CSNK2A10.33293305
98STK30.32667255
99NEK60.31699130
100WNK40.31395829

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.78227171
2Mismatch repair_Homo sapiens_hsa034303.51090370
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.14324849
4Cell cycle_Homo sapiens_hsa041102.98817473
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.79893061
6Spliceosome_Homo sapiens_hsa030402.78558005
7Base excision repair_Homo sapiens_hsa034102.78140106
8RNA transport_Homo sapiens_hsa030132.75559160
9Nucleotide excision repair_Homo sapiens_hsa034202.53884553
10Ribosome_Homo sapiens_hsa030102.42998702
11Homologous recombination_Homo sapiens_hsa034402.34634200
12Non-homologous end-joining_Homo sapiens_hsa034502.33825497
13One carbon pool by folate_Homo sapiens_hsa006702.13054437
14mRNA surveillance pathway_Homo sapiens_hsa030152.02808947
15Fanconi anemia pathway_Homo sapiens_hsa034602.01247939
16RNA polymerase_Homo sapiens_hsa030201.82820286
17Proteasome_Homo sapiens_hsa030501.79979246
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64871357
19Thyroid cancer_Homo sapiens_hsa052161.62265692
20Pyrimidine metabolism_Homo sapiens_hsa002401.59575395
21Basal transcription factors_Homo sapiens_hsa030221.55824798
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.52110677
23Chronic myeloid leukemia_Homo sapiens_hsa052201.47465385
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.37105467
25Pentose phosphate pathway_Homo sapiens_hsa000301.32766902
26Pancreatic cancer_Homo sapiens_hsa052121.31996730
27Biosynthesis of amino acids_Homo sapiens_hsa012301.26651293
28MicroRNAs in cancer_Homo sapiens_hsa052061.17455750
29Viral carcinogenesis_Homo sapiens_hsa052031.15530072
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12624050
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11452159
32Pyruvate metabolism_Homo sapiens_hsa006201.09124116
33Adherens junction_Homo sapiens_hsa045201.08592551
34Carbon metabolism_Homo sapiens_hsa012001.05205079
35Oocyte meiosis_Homo sapiens_hsa041141.04120073
36Colorectal cancer_Homo sapiens_hsa052101.03398020
37Non-small cell lung cancer_Homo sapiens_hsa052231.01883180
38Epstein-Barr virus infection_Homo sapiens_hsa051690.98260512
39RNA degradation_Homo sapiens_hsa030180.97400558
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91936718
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91256397
42Small cell lung cancer_Homo sapiens_hsa052220.90052635
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88017052
44Purine metabolism_Homo sapiens_hsa002300.87137038
45Acute myeloid leukemia_Homo sapiens_hsa052210.87071280
46Shigellosis_Homo sapiens_hsa051310.85281241
47Lysine degradation_Homo sapiens_hsa003100.82142834
48Renal cell carcinoma_Homo sapiens_hsa052110.81279747
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81170571
50HTLV-I infection_Homo sapiens_hsa051660.78800877
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75868975
52Endometrial cancer_Homo sapiens_hsa052130.74804908
53Bladder cancer_Homo sapiens_hsa052190.72361235
54Glioma_Homo sapiens_hsa052140.70769308
55mTOR signaling pathway_Homo sapiens_hsa041500.70169136
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.70150526
57Sulfur relay system_Homo sapiens_hsa041220.69463331
58ErbB signaling pathway_Homo sapiens_hsa040120.68486359
59Proteoglycans in cancer_Homo sapiens_hsa052050.65945053
60Folate biosynthesis_Homo sapiens_hsa007900.64495211
61Prostate cancer_Homo sapiens_hsa052150.62053956
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61939108
63Steroid biosynthesis_Homo sapiens_hsa001000.61125752
64Hepatitis B_Homo sapiens_hsa051610.59522807
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59387724
66Alcoholism_Homo sapiens_hsa050340.57665568
67p53 signaling pathway_Homo sapiens_hsa041150.57419539
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56435198
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55507496
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55064561
71VEGF signaling pathway_Homo sapiens_hsa043700.54334574
72Melanoma_Homo sapiens_hsa052180.53914570
73Insulin signaling pathway_Homo sapiens_hsa049100.52007506
74Wnt signaling pathway_Homo sapiens_hsa043100.51427391
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51221396
76Glutathione metabolism_Homo sapiens_hsa004800.50071751
77N-Glycan biosynthesis_Homo sapiens_hsa005100.49668299
78Hippo signaling pathway_Homo sapiens_hsa043900.47430921
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43006465
80Focal adhesion_Homo sapiens_hsa045100.42846723
81TGF-beta signaling pathway_Homo sapiens_hsa043500.42358316
82AMPK signaling pathway_Homo sapiens_hsa041520.41900269
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40237073
84Systemic lupus erythematosus_Homo sapiens_hsa053220.39587467
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37387729
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36571424
87Huntingtons disease_Homo sapiens_hsa050160.36541307
88Apoptosis_Homo sapiens_hsa042100.35437173
89Vitamin B6 metabolism_Homo sapiens_hsa007500.33500683
90Pathways in cancer_Homo sapiens_hsa052000.31003841
91Fatty acid elongation_Homo sapiens_hsa000620.30747563
92Fructose and mannose metabolism_Homo sapiens_hsa000510.30382104
93HIF-1 signaling pathway_Homo sapiens_hsa040660.29128137
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28656041
95Protein export_Homo sapiens_hsa030600.26051779
96Selenocompound metabolism_Homo sapiens_hsa004500.25561411
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24790608
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22192898
99Inositol phosphate metabolism_Homo sapiens_hsa005620.20345587
100Herpes simplex infection_Homo sapiens_hsa051680.19890590

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