CKS1BP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.87234009
2ATP synthesis coupled proton transport (GO:0015986)7.03881070
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.03881070
4establishment of protein localization to mitochondrial membrane (GO:0090151)6.71709580
5protein-cofactor linkage (GO:0018065)6.64370463
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.65885592
7respiratory electron transport chain (GO:0022904)5.65170351
8electron transport chain (GO:0022900)5.57740488
9proteasome assembly (GO:0043248)4.86958658
10viral transcription (GO:0019083)4.79767089
11translational termination (GO:0006415)4.69628625
12ribosomal small subunit assembly (GO:0000028)4.59027413
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.46407643
14chromatin remodeling at centromere (GO:0031055)4.41403886
15cotranslational protein targeting to membrane (GO:0006613)4.39894538
16regulation of mitochondrial translation (GO:0070129)4.36882760
17protein targeting to ER (GO:0045047)4.36188579
18CENP-A containing nucleosome assembly (GO:0034080)4.33503749
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.29571572
20establishment of integrated proviral latency (GO:0075713)4.25482533
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.14075386
22mitochondrial respiratory chain complex I assembly (GO:0032981)4.14075386
23NADH dehydrogenase complex assembly (GO:0010257)4.14075386
24protein localization to endoplasmic reticulum (GO:0070972)4.07688385
25translational elongation (GO:0006414)4.03205940
26spliceosomal snRNP assembly (GO:0000387)4.00923508
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.95103229
28protein neddylation (GO:0045116)3.92587932
29activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.88288086
30protein complex biogenesis (GO:0070271)3.85526817
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.83901001
32chaperone-mediated protein transport (GO:0072321)3.74881102
33oxidative phosphorylation (GO:0006119)3.74368714
34mitochondrial respiratory chain complex assembly (GO:0033108)3.74245414
35positive regulation of prostaglandin secretion (GO:0032308)3.73898311
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.71625580
37termination of RNA polymerase III transcription (GO:0006386)3.71625580
38ATP biosynthetic process (GO:0006754)3.70860759
39purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.69423768
40viral mRNA export from host cell nucleus (GO:0046784)3.67301662
41purine nucleoside triphosphate biosynthetic process (GO:0009145)3.65561803
42GTP biosynthetic process (GO:0006183)3.64873295
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.61587519
44cellular protein complex disassembly (GO:0043624)3.59345089
45histone exchange (GO:0043486)3.52340942
46inner mitochondrial membrane organization (GO:0007007)3.51724544
47spliceosomal complex assembly (GO:0000245)3.51161392
48innate immune response in mucosa (GO:0002227)3.47872938
49establishment of viral latency (GO:0019043)3.40838835
50translational initiation (GO:0006413)3.39338559
51regulation of prostaglandin secretion (GO:0032306)3.36932340
52ribonucleoside triphosphate biosynthetic process (GO:0009201)3.32815939
53sequestering of actin monomers (GO:0042989)3.31155151
54UTP biosynthetic process (GO:0006228)3.30653840
55viral life cycle (GO:0019058)3.29598412
56DNA ligation (GO:0006266)3.29233475
57translation (GO:0006412)3.28963482
58regulation of DNA endoreduplication (GO:0032875)3.28340135
59histone mRNA metabolic process (GO:0008334)3.17641530
60UTP metabolic process (GO:0046051)3.14829952
61DNA strand elongation involved in DNA replication (GO:0006271)3.13093598
62regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.11226386
63regulation of mitotic spindle checkpoint (GO:1903504)3.11226386
64cAMP catabolic process (GO:0006198)3.06853668
65protein complex disassembly (GO:0043241)3.03854803
66ribosomal large subunit biogenesis (GO:0042273)3.03281596
67intracellular protein transmembrane import (GO:0044743)3.02645864
68hydrogen ion transmembrane transport (GO:1902600)3.01709720
69macromolecular complex disassembly (GO:0032984)3.01553354
70primitive streak formation (GO:0090009)2.98398243
71nuclear-transcribed mRNA catabolic process (GO:0000956)2.98339843
72DNA replication-independent nucleosome assembly (GO:0006336)2.97575572
73DNA replication-independent nucleosome organization (GO:0034724)2.97575572
74protein targeting to mitochondrion (GO:0006626)2.97064465
75establishment of protein localization to mitochondrion (GO:0072655)2.96529543
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95393593
77prenylation (GO:0097354)2.94996973
78protein prenylation (GO:0018342)2.94996973
79DNA strand elongation (GO:0022616)2.92152377
80purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.86358062
81purine nucleoside monophosphate biosynthetic process (GO:0009127)2.86358062
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85593036
83DNA replication checkpoint (GO:0000076)2.83987518
84cell fate commitment involved in formation of primary germ layer (GO:0060795)2.83683370
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83647441
86protein localization to mitochondrion (GO:0070585)2.83461520
87regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.80786485
88formation of translation preinitiation complex (GO:0001731)2.80612016
89mRNA catabolic process (GO:0006402)2.80321705
90telomere maintenance via semi-conservative replication (GO:0032201)2.80030289
91protein targeting to membrane (GO:0006612)2.79906016
92nucleoside triphosphate biosynthetic process (GO:0009142)2.78752867
93centriole replication (GO:0007099)2.78503993
94RNA catabolic process (GO:0006401)2.78005776
95pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.77936743
96guanosine-containing compound biosynthetic process (GO:1901070)2.77624779
97mucosal immune response (GO:0002385)2.76834576
98negative regulation of heart rate (GO:0010459)2.75335957
99CTP biosynthetic process (GO:0006241)2.72056668
100CTP metabolic process (GO:0046036)2.72056668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.43011920
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.87395451
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.55658592
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.79927961
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.79069652
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.68420000
7E2F7_22180533_ChIP-Seq_HELA_Human3.45429022
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.16221516
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.78779776
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78430417
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78266102
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.65439925
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61794983
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58285446
15ELK1_19687146_ChIP-ChIP_HELA_Human2.58160907
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54405858
17VDR_23849224_ChIP-Seq_CD4+_Human2.48534680
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.47951271
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45933916
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.45503370
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41882634
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39680280
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29301699
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21128713
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.20973979
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17621755
27SOX2_16153702_ChIP-ChIP_HESCs_Human2.12999392
28TTF2_22483619_ChIP-Seq_HELA_Human2.12865338
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09033249
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.05235029
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01869694
32FOXP3_21729870_ChIP-Seq_TREG_Human2.01402732
33POU5F1_16153702_ChIP-ChIP_HESCs_Human2.00226619
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.98315616
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96291636
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.95700722
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93653059
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.91434897
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91279453
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.83448609
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78553066
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74092400
43IRF1_19129219_ChIP-ChIP_H3396_Human1.70870221
44MYC_18940864_ChIP-ChIP_HL60_Human1.69434220
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65197697
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63933213
47DCP1A_22483619_ChIP-Seq_HELA_Human1.61436078
48XRN2_22483619_ChIP-Seq_HELA_Human1.60388308
49AR_21909140_ChIP-Seq_LNCAP_Human1.60290266
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.59157932
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58054906
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55227788
53GATA1_22025678_ChIP-Seq_K562_Human1.52994135
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52481346
55CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.47067499
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.45283313
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44318294
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37669946
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.33042882
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32151153
61CIITA_25753668_ChIP-Seq_RAJI_Human1.31310382
62EWS_26573619_Chip-Seq_HEK293_Human1.27937545
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27671644
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26788807
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25369912
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23295422
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19248300
68PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18849325
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18454809
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.16349740
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15068568
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11804805
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11461604
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10687462
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10133066
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08227195
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06981811
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.05253267
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03943104
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03023907
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00576569
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99889689
83ELK1_22589737_ChIP-Seq_MCF10A_Human0.99383555
84GABP_19822575_ChIP-Seq_HepG2_Human0.99356545
85STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98448642
86ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98386751
87MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98377286
88SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96415641
89GATA1_26923725_Chip-Seq_HPCs_Mouse0.95443030
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94067850
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94023738
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93683557
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91495879
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.91310000
95ERG_20517297_ChIP-Seq_VCAP_Human0.88247774
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86254828
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84244908
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83740523
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83162859
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80728384

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.54354617
2MP0002009_preneoplasia3.87820076
3MP0002166_altered_tumor_susceptibility3.16114764
4MP0008789_abnormal_olfactory_epithelium3.15232977
5MP0002006_tumorigenesis2.82812207
6MP0006292_abnormal_olfactory_placode2.77194620
7MP0010094_abnormal_chromosome_stability2.74016522
8MP0003283_abnormal_digestive_organ2.71157730
9MP0006072_abnormal_retinal_apoptosis2.66656166
10MP0005377_hearing/vestibular/ear_phenot2.58621598
11MP0003878_abnormal_ear_physiology2.58621598
12MP0003136_yellow_coat_color2.50920226
13MP0004133_heterotaxia2.41339699
14MP0003077_abnormal_cell_cycle2.26210078
15MP0005394_taste/olfaction_phenotype2.25623678
16MP0005499_abnormal_olfactory_system2.25623678
17MP0003011_delayed_dark_adaptation2.12831664
18MP0001529_abnormal_vocalization2.12108982
19MP0004957_abnormal_blastocyst_morpholog2.09223434
20MP0006036_abnormal_mitochondrial_physio2.03019831
21MP0003806_abnormal_nucleotide_metabolis2.01878846
22MP0008932_abnormal_embryonic_tissue1.95654242
23MP0004147_increased_porphyrin_level1.88833229
24MP0008007_abnormal_cellular_replicative1.84998652
25MP0003315_abnormal_perineum_morphology1.83963782
26MP0003718_maternal_effect1.70366234
27MP0002277_abnormal_respiratory_mucosa1.70068091
28MP0009379_abnormal_foot_pigmentation1.61013472
29MP0006035_abnormal_mitochondrial_morpho1.60618622
30MP0002160_abnormal_reproductive_system1.60317393
31MP0003111_abnormal_nucleus_morphology1.60203484
32MP0003763_abnormal_thymus_physiology1.54332311
33MP0001835_abnormal_antigen_presentation1.53893525
34MP0005084_abnormal_gallbladder_morpholo1.53004999
35MP0010030_abnormal_orbit_morphology1.50666551
36MP0009697_abnormal_copulation1.48501542
37MP0001919_abnormal_reproductive_system1.42923118
38MP0001485_abnormal_pinna_reflex1.42842519
39MP0008058_abnormal_DNA_repair1.37348816
40MP0002282_abnormal_trachea_morphology1.36063460
41MP0001346_abnormal_lacrimal_gland1.35688151
42MP0000566_synostosis1.35630440
43MP0002090_abnormal_vision1.34554768
44MP0003119_abnormal_digestive_system1.28772904
45MP0003186_abnormal_redox_activity1.28712873
46MP0005671_abnormal_response_to1.27089326
47MP0005389_reproductive_system_phenotype1.24101067
48MP0008877_abnormal_DNA_methylation1.22328738
49MP0005645_abnormal_hypothalamus_physiol1.18580795
50MP0003693_abnormal_embryo_hatching1.15015323
51MP0000685_abnormal_immune_system1.14873995
52MP0001286_abnormal_eye_development1.14832934
53MP0002877_abnormal_melanocyte_morpholog1.07916317
54MP0001293_anophthalmia1.06501894
55MP0005646_abnormal_pituitary_gland1.06122307
56MP0003938_abnormal_ear_development1.05424480
57MP0005253_abnormal_eye_physiology1.05150181
58MP0009333_abnormal_splenocyte_physiolog1.04974587
59MP0003786_premature_aging1.02767780
60MP0002653_abnormal_ependyma_morphology1.01752716
61MP0003941_abnormal_skin_development1.00220196
62MP0003123_paternal_imprinting0.95102485
63MP0004742_abnormal_vestibular_system0.94174835
64MP0008961_abnormal_basal_metabolism0.90698786
65MP0002233_abnormal_nose_morphology0.90347728
66MP0005410_abnormal_fertilization0.90139136
67MP0005197_abnormal_uvea_morphology0.88642024
68MP0005220_abnormal_exocrine_pancreas0.88525501
69MP0008872_abnormal_physiological_respon0.88103099
70MP0003937_abnormal_limbs/digits/tail_de0.87384514
71MP0008057_abnormal_DNA_replication0.87303377
72MP0008875_abnormal_xenobiotic_pharmacok0.86670738
73MP0000569_abnormal_digit_pigmentation0.85082736
74MP0009764_decreased_sensitivity_to0.84359347
75MP0000631_abnormal_neuroendocrine_gland0.83069623
76MP0000579_abnormal_nail_morphology0.82330828
77MP0000350_abnormal_cell_proliferation0.81303708
78MP0001800_abnormal_humoral_immune0.80098272
79MP0004142_abnormal_muscle_tone0.79581065
80MP0003943_abnormal_hepatobiliary_system0.78670909
81MP0002234_abnormal_pharynx_morphology0.73615127
82MP0001440_abnormal_grooming_behavior0.70854259
83MP0005670_abnormal_white_adipose0.70236215
84MP0002751_abnormal_autonomic_nervous0.70083269
85MP0009053_abnormal_anal_canal0.68551876
86MP0004145_abnormal_muscle_electrophysio0.62360009
87MP0001944_abnormal_pancreas_morphology0.61663842
88MP0000313_abnormal_cell_death0.61449262
89MP0000639_abnormal_adrenal_gland0.60653172
90MP0002557_abnormal_social/conspecific_i0.60495737
91MP0005636_abnormal_mineral_homeostasis0.59314417
92MP0002938_white_spotting0.58786307
93MP0005387_immune_system_phenotype0.58506681
94MP0001790_abnormal_immune_system0.58506681
95MP0002075_abnormal_coat/hair_pigmentati0.58351461
96MP0005000_abnormal_immune_tolerance0.57759934
97MP0001186_pigmentation_phenotype0.56987258
98MP0005195_abnormal_posterior_eye0.55682928
99MP0000013_abnormal_adipose_tissue0.55272734
100MP0000358_abnormal_cell_content/0.55177633

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.20689532
2Abnormal mitochondria in muscle tissue (HP:0008316)5.65864467
3Acute encephalopathy (HP:0006846)5.38936807
4Mitochondrial inheritance (HP:0001427)5.01390017
5Progressive macrocephaly (HP:0004481)4.97352424
6Congenital, generalized hypertrichosis (HP:0004540)4.91689968
7Increased CSF lactate (HP:0002490)4.72188166
8Oral leukoplakia (HP:0002745)4.27360775
9Increased hepatocellular lipid droplets (HP:0006565)4.15824361
10Leukodystrophy (HP:0002415)4.06117836
11Neuroendocrine neoplasm (HP:0100634)4.05741057
12Cerebral edema (HP:0002181)3.92336383
13Agitation (HP:0000713)3.83231442
14Hepatocellular necrosis (HP:0001404)3.76620016
15Lipid accumulation in hepatocytes (HP:0006561)3.76283840
16Aplastic anemia (HP:0001915)3.51179331
17Hepatic necrosis (HP:0002605)3.37974793
183-Methylglutaconic aciduria (HP:0003535)3.33777273
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.13410500
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.13410500
21Increased intramyocellular lipid droplets (HP:0012240)3.13158678
22Abnormality of the prostate (HP:0008775)3.11926912
23Optic disc pallor (HP:0000543)3.03685486
24Abnormality of the labia minora (HP:0012880)3.02354052
25Renal Fanconi syndrome (HP:0001994)2.98116686
26Woolly hair (HP:0002224)2.95314167
27Increased serum lactate (HP:0002151)2.91954400
28Respiratory failure (HP:0002878)2.90513029
29Prostate neoplasm (HP:0100787)2.89635558
30Tinnitus (HP:0000360)2.83009464
31Maternal diabetes (HP:0009800)2.80886318
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.78267574
33Abnormality of alanine metabolism (HP:0010916)2.78267574
34Hyperalaninemia (HP:0003348)2.78267574
35Lactic acidosis (HP:0003128)2.74450873
36Restlessness (HP:0000711)2.71337969
37Increased muscle lipid content (HP:0009058)2.64079558
38Exercise intolerance (HP:0003546)2.57017122
39Conical tooth (HP:0000698)2.56181023
40Septo-optic dysplasia (HP:0100842)2.48770881
41Methylmalonic acidemia (HP:0002912)2.46975656
42Delayed CNS myelination (HP:0002188)2.46286457
43Hyperglycinemia (HP:0002154)2.45991015
44Abnormal number of erythroid precursors (HP:0012131)2.42630581
45Respiratory difficulties (HP:0002880)2.39816741
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37355206
47Exertional dyspnea (HP:0002875)2.33908429
48Increased density of long bones (HP:0006392)2.31908526
49Pancytopenia (HP:0001876)2.31114712
50Pallor (HP:0000980)2.30987697
51Macrocytic anemia (HP:0001972)2.29702030
52Abnormality of cells of the erythroid lineage (HP:0012130)2.28378579
53Pheochromocytoma (HP:0002666)2.25911740
54Type II lissencephaly (HP:0007260)2.24386062
55Striae distensae (HP:0001065)2.23924586
56Abnormality of renal resorption (HP:0011038)2.18541738
57Renal cortical cysts (HP:0000803)2.17796508
58Abnormality of placental membranes (HP:0011409)2.16988033
59Amniotic constriction ring (HP:0009775)2.16988033
60Abnormality of serum amino acid levels (HP:0003112)2.14373433
61Severe visual impairment (HP:0001141)2.14053940
62Neoplasm of the peripheral nervous system (HP:0100007)2.11237524
63Onycholysis (HP:0001806)2.08374924
64IgM deficiency (HP:0002850)2.07599068
65Methylmalonic aciduria (HP:0012120)2.05656451
66Hypogonadotrophic hypogonadism (HP:0000044)2.04827301
67Abnormality of male internal genitalia (HP:0000022)2.02165760
68Concave nail (HP:0001598)2.01522437
69X-linked dominant inheritance (HP:0001423)2.01169890
70Cellular immunodeficiency (HP:0005374)2.00754939
71Bilateral microphthalmos (HP:0007633)2.00632811
72Central scotoma (HP:0000603)1.98205365
73Blindness (HP:0000618)1.98166657
74Absent septum pellucidum (HP:0001331)1.97855686
75Cleft eyelid (HP:0000625)1.97001973
76Hypothermia (HP:0002045)1.95756282
77Lethargy (HP:0001254)1.93867846
78Septate vagina (HP:0001153)1.92956208
79Hypercortisolism (HP:0001578)1.92255507
80Tubulointerstitial nephritis (HP:0001970)1.90181765
81Symptomatic seizures (HP:0011145)1.89881078
82Megaloblastic anemia (HP:0001889)1.85586587
83Multiple enchondromatosis (HP:0005701)1.85117040
84Abnormality of the septum pellucidum (HP:0007375)1.84818950
85Retinal dysplasia (HP:0007973)1.84532304
86Type I diabetes mellitus (HP:0100651)1.81021268
87Abnormality of the renal cortex (HP:0011035)1.79113670
88Anxiety (HP:0000739)1.78153540
89Persistence of primary teeth (HP:0006335)1.78130104
90Gastrointestinal stroma tumor (HP:0100723)1.73300669
91Aplasia/hypoplasia of the uterus (HP:0008684)1.71499884
92Nephroblastoma (Wilms tumor) (HP:0002667)1.68133420
93Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66612071
94CNS demyelination (HP:0007305)1.61890242
95Hypoglycemic seizures (HP:0002173)1.61463552
96Generalized aminoaciduria (HP:0002909)1.58370531
97Abnormality of the vocal cords (HP:0008777)1.57220644
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.56852840
99Ridged nail (HP:0001807)1.56297258
100Hypoplasia of the uterus (HP:0000013)1.56279995

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.34421628
2TLK14.68620520
3VRK14.21213667
4ZAK3.87418109
5CDC73.53788143
6TAF13.17256375
7TXK2.87239179
8BUB12.70900071
9NEK12.54095889
10MAP4K22.33211212
11NUAK12.31074202
12PNCK2.24730344
13CDK192.17240875
14BRD42.10768852
15WEE11.94620542
16MAP2K21.81909454
17PASK1.73749598
18SRPK11.68391283
19KDR1.61554912
20NME21.58846814
21KIT1.51143545
22STK161.50403419
23MKNK11.47251634
24DAPK31.43871929
25MUSK1.41125502
26CHEK21.32937007
27AURKA1.28245098
28SMG11.21529751
29MAP3K141.19855908
30AURKB1.11953864
31NME11.11346203
32EIF2AK21.04557786
33PLK41.01572965
34PLK31.00224621
35BRSK20.97990383
36RPS6KA50.95477464
37SCYL20.94516207
38IKBKE0.86812968
39MAPKAPK50.84556120
40ADRBK20.81701866
41PLK10.79719444
42CSF1R0.76876774
43OXSR10.76702887
44CSNK1G20.76262824
45BMPR20.73682549
46TRIM280.71615927
47DYRK1A0.70488359
48EPHA40.68600150
49CSNK1G10.66476341
50NEK20.65770833
51TTK0.65732853
52LYN0.63190196
53IKBKB0.62257368
54DYRK20.62186560
55IRAK20.61409691
56MST40.60951594
57BRSK10.60881616
58CSNK1G30.60761751
59IRAK40.57997783
60WNK40.57914069
61BLK0.53727976
62TNIK0.52917196
63TBK10.51333779
64DAPK10.50404047
65CSNK2A20.47938164
66BCKDK0.47907754
67UHMK10.47832379
68CSNK2A10.45464217
69PBK0.44581745
70MST1R0.44361383
71STK240.44083529
72CSNK1A1L0.38842695
73CHUK0.38585543
74MAPK40.38584540
75TSSK60.37123708
76CDK70.36075215
77EGFR0.33418116
78ALK0.33239421
79STK390.33035902
80SYK0.32054063
81CSNK1E0.30619820
82CHEK10.30440791
83FGFR10.28542354
84PIM10.28068823
85MATK0.27729757
86FLT30.27568380
87MKNK20.27092135
88CDK140.25176803
89PRKCQ0.25169617
90PDK20.24796111
91CDK90.24048028
92CAMK1D0.23923808
93GRK50.23465312
94ATR0.23072869
95PKN10.22739392
96ERBB20.22628265
97INSR0.21049984
98CAMK1G0.20520119
99PRKCD0.20431220
100CDK11A0.20162276

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.12856002
2Oxidative phosphorylation_Homo sapiens_hsa001903.97090769
3Ribosome_Homo sapiens_hsa030103.82371128
4Parkinsons disease_Homo sapiens_hsa050123.54051463
5Proteasome_Homo sapiens_hsa030503.43535741
6Asthma_Homo sapiens_hsa053102.76107544
7Protein export_Homo sapiens_hsa030602.71244734
8Huntingtons disease_Homo sapiens_hsa050162.53189530
9Alzheimers disease_Homo sapiens_hsa050102.42148643
10RNA polymerase_Homo sapiens_hsa030202.41514318
11DNA replication_Homo sapiens_hsa030302.37993164
12Allograft rejection_Homo sapiens_hsa053302.17772083
13Alcoholism_Homo sapiens_hsa050342.12734624
14Autoimmune thyroid disease_Homo sapiens_hsa053202.11363440
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.05738243
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.04500285
17Graft-versus-host disease_Homo sapiens_hsa053322.00874402
18Spliceosome_Homo sapiens_hsa030401.99162170
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.89274287
20Fatty acid elongation_Homo sapiens_hsa000621.81143874
21Mismatch repair_Homo sapiens_hsa034301.79953957
22Type I diabetes mellitus_Homo sapiens_hsa049401.76267227
23Homologous recombination_Homo sapiens_hsa034401.76095094
24Non-homologous end-joining_Homo sapiens_hsa034501.67699525
25One carbon pool by folate_Homo sapiens_hsa006701.61437797
26Cardiac muscle contraction_Homo sapiens_hsa042601.58689505
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57028150
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.55625927
29Viral myocarditis_Homo sapiens_hsa054161.47428486
30Pyrimidine metabolism_Homo sapiens_hsa002401.45271734
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33459550
32RNA degradation_Homo sapiens_hsa030181.33330196
33Purine metabolism_Homo sapiens_hsa002301.23262843
34Base excision repair_Homo sapiens_hsa034101.20608258
35Antigen processing and presentation_Homo sapiens_hsa046121.15368252
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10717073
37Cell cycle_Homo sapiens_hsa041101.03576088
38Phenylalanine metabolism_Homo sapiens_hsa003601.03149010
39RNA transport_Homo sapiens_hsa030131.02468649
40Staphylococcus aureus infection_Homo sapiens_hsa051500.97893255
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94103273
42Rheumatoid arthritis_Homo sapiens_hsa053230.94024930
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88532615
44Leishmaniasis_Homo sapiens_hsa051400.85835458
45Pyruvate metabolism_Homo sapiens_hsa006200.85438463
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83599899
47Sulfur relay system_Homo sapiens_hsa041220.82306467
48Basal transcription factors_Homo sapiens_hsa030220.78512194
49Epstein-Barr virus infection_Homo sapiens_hsa051690.77405130
50Nucleotide excision repair_Homo sapiens_hsa034200.76228721
51p53 signaling pathway_Homo sapiens_hsa041150.75610059
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72557800
53Herpes simplex infection_Homo sapiens_hsa051680.71541060
54Primary immunodeficiency_Homo sapiens_hsa053400.70258733
55Fanconi anemia pathway_Homo sapiens_hsa034600.70180992
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68321375
57Selenocompound metabolism_Homo sapiens_hsa004500.67274079
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.67031968
59Viral carcinogenesis_Homo sapiens_hsa052030.64356874
60Tyrosine metabolism_Homo sapiens_hsa003500.64161939
61Propanoate metabolism_Homo sapiens_hsa006400.61014290
62Linoleic acid metabolism_Homo sapiens_hsa005910.59911902
63Butanoate metabolism_Homo sapiens_hsa006500.57419549
64Tryptophan metabolism_Homo sapiens_hsa003800.53421300
65Vitamin digestion and absorption_Homo sapiens_hsa049770.49684139
66Metabolic pathways_Homo sapiens_hsa011000.44415416
67Carbon metabolism_Homo sapiens_hsa012000.43645332
68Nitrogen metabolism_Homo sapiens_hsa009100.43343337
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42154569
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40962782
71Biosynthesis of amino acids_Homo sapiens_hsa012300.39512633
72Basal cell carcinoma_Homo sapiens_hsa052170.39363787
73Hematopoietic cell lineage_Homo sapiens_hsa046400.33565353
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32646648
75Caffeine metabolism_Homo sapiens_hsa002320.32576081
76beta-Alanine metabolism_Homo sapiens_hsa004100.29118275
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29087752
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28545595
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27438530
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26543653
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.24013621
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.23989906
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23656393
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23647569
85Retinol metabolism_Homo sapiens_hsa008300.21684359
86Morphine addiction_Homo sapiens_hsa050320.20763455
87Chemical carcinogenesis_Homo sapiens_hsa052040.20418685
88Influenza A_Homo sapiens_hsa051640.19879497
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19792533
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19700604
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19644085
92mRNA surveillance pathway_Homo sapiens_hsa030150.18932669
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18866740
94Oocyte meiosis_Homo sapiens_hsa041140.18826326
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18572966
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.15417048
97Histidine metabolism_Homo sapiens_hsa003400.15109175
98Hedgehog signaling pathway_Homo sapiens_hsa043400.14999727
99Arachidonic acid metabolism_Homo sapiens_hsa005900.14949844
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14135262

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