ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	oxygen transport (GO:0015671)	7.95745244
2	gas transport (GO:0015669)	6.43715189
3	cellular response to zinc ion (GO:0071294)	5.44058559
4	rRNA modification (GO:0000154)	5.28723982
5	cellular response to cadmium ion (GO:0071276)	4.95796590
6	proteasome assembly (GO:0043248)	4.88023860
7	rRNA methylation (GO:0031167)	4.87070294
8	cullin deneddylation (GO:0010388)	4.82063056
9	DNA deamination (GO:0045006)	4.80301803
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.69381173
11	maturation of 5.8S rRNA (GO:0000460)	4.65872736
12	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.59848826
13	nonmotile primary cilium assembly (GO:0035058)	4.23675402
14	ribosome assembly (GO:0042255)	4.18461758
15	protein deneddylation (GO:0000338)	4.17099322
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.08838295
17	ATP synthesis coupled proton transport (GO:0015986)	4.08838295
18	synapsis (GO:0007129)	3.89712054
19	carnitine metabolic process (GO:0009437)	3.80390767
20	DNA double-strand break processing (GO:0000729)	3.80298939
21	erythrocyte maturation (GO:0043249)	3.73412031
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.64983813
23	UTP biosynthetic process (GO:0006228)	3.62774625
24	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.59430075
25	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.58313845
26	microtubule severing (GO:0051013)	3.49623991
27	GTP biosynthetic process (GO:0006183)	3.49469034
28	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.48111313
29	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.40747855
30	nucleobase biosynthetic process (GO:0046112)	3.40352588
31	DNA catabolic process, exonucleolytic (GO:0000738)	3.38120065
32	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.37702539
33	mitotic metaphase plate congression (GO:0007080)	3.35407057
34	protein-cofactor linkage (GO:0018065)	3.35214676
35	meiotic chromosome segregation (GO:0045132)	3.34741355
36	NADH dehydrogenase complex assembly (GO:0010257)	3.33172904
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.33172904
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.33172904
39	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.31827727
40	respiratory electron transport chain (GO:0022904)	3.27742384
41	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.26344178
42	metaphase plate congression (GO:0051310)	3.22818262
43	pseudouridine synthesis (GO:0001522)	3.20447348
44	electron transport chain (GO:0022900)	3.19492017
45	transcription from mitochondrial promoter (GO:0006390)	3.14290703
46	peptide catabolic process (GO:0043171)	3.13920750
47	UTP metabolic process (GO:0046051)	3.12750124
48	DNA replication checkpoint (GO:0000076)	3.11214381
49	regulation of transcription from RNA polymerase I promoter (GO:0006356)	3.10146444
50	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.09856483
51	CENP-A containing nucleosome assembly (GO:0034080)	3.08545619
52	amino-acid betaine metabolic process (GO:0006577)	3.08398211
53	chromatin remodeling at centromere (GO:0031055)	3.07393564
54	spliceosomal snRNP assembly (GO:0000387)	3.00777784
55	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.96798509
56	water-soluble vitamin biosynthetic process (GO:0042364)	2.96663949
57	endothelial tube morphogenesis (GO:0061154)	2.95995191
58	morphogenesis of an endothelium (GO:0003159)	2.95995191
59	protein K11-linked deubiquitination (GO:0035871)	2.95518161
60	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.94209906
61	translesion synthesis (GO:0019985)	2.92226211
62	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.92013353
63	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.91810029
64	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.91810029
65	negative regulation of response to food (GO:0032096)	2.90946390
66	negative regulation of appetite (GO:0032099)	2.90946390
67	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.88474670
68	chromosome organization involved in meiosis (GO:0070192)	2.86429930
69	protein localization to kinetochore (GO:0034501)	2.86205951
70	male meiosis I (GO:0007141)	2.84780497
71	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.84143310
72	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.83562619
73	piRNA metabolic process (GO:0034587)	2.83481418
74	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.82741741
75	striatum development (GO:0021756)	2.82674675
76	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.82672936
77	CTP metabolic process (GO:0046036)	2.80784505
78	CTP biosynthetic process (GO:0006241)	2.80784505
79	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.79472130
80	termination of RNA polymerase I transcription (GO:0006363)	2.78795946
81	mitochondrial respiratory chain complex assembly (GO:0033108)	2.77453815
82	guanosine-containing compound biosynthetic process (GO:1901070)	2.76875586
83	regulation of cilium movement (GO:0003352)	2.75154465
84	positive regulation of cell fate commitment (GO:0010455)	2.74260008
85	protein complex biogenesis (GO:0070271)	2.73826624
86	cellular response to leptin stimulus (GO:0044320)	2.72635845
87	meiosis I (GO:0007127)	2.71901672
88	protein localization to cilium (GO:0061512)	2.71392218
89	meiotic nuclear division (GO:0007126)	2.71032743
90	histone exchange (GO:0043486)	2.70331829
91	male meiosis (GO:0007140)	2.69351015
92	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.68521768
93	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.67876968
94	secondary heart field specification (GO:0003139)	2.67446820
95	heart field specification (GO:0003128)	2.67446820
96	mismatch repair (GO:0006298)	2.63608875
97	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.63422094
98	aldehyde catabolic process (GO:0046185)	2.62718596
99	chaperone-mediated protein transport (GO:0072321)	2.61763455
100	transcription from RNA polymerase I promoter (GO:0006360)	2.61272328

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.45490091
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.06367731
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.71491790
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.32960778
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.35598179
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.16956681
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.05719395
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.04977726
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.02389118
10	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.74611036
11	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.66938735
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.58554108
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.47788834
14	VDR_22108803_ChIP-Seq_LS180_Human	2.38018467
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.36919660
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.29900670
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.24033219
18	DCP1A_22483619_ChIP-Seq_HELA_Human	2.23209591
19	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.07256992
20	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.00615286
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.00535160
22	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.93638910
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.89644313
24	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.87395957
25	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.87395957
26	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.87395957
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.86189975
28	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.85805603
29	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.82521600
30	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.75577871
31	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.75049672
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.74564640
33	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.74546965
34	EWS_26573619_Chip-Seq_HEK293_Human	1.73127892
35	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.73089828
36	ZNF274_21170338_ChIP-Seq_K562_Hela	1.72063200
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.71386900
38	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.71183963
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.68939238
40	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.61113311
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.60426425
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.59011524
43	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.58987170
44	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.52976094
45	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.51147221
46	TTF2_22483619_ChIP-Seq_HELA_Human	1.51140753
47	TAF15_26573619_Chip-Seq_HEK293_Human	1.48323604
48	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.47800168
49	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.37853674
50	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.37700320
51	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.37214663
52	FUS_26573619_Chip-Seq_HEK293_Human	1.36987969
53	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.32884965
54	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.29953744
55	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.25943863
56	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.24512307
57	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.21905277
58	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.19886174
59	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.19201713
60	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.17242733
61	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.17165407
62	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.16377426
63	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.11942302
64	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06835018
65	IGF1R_20145208_ChIP-Seq_DFB_Human	1.06478789
66	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.06095092
67	XRN2_22483619_ChIP-Seq_HELA_Human	1.03398070
68	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.03310984
69	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.03245462
70	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.00776661
71	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.00502529
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98983949
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98983949
74	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.98413334
75	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97378778
76	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97378778
77	ER_23166858_ChIP-Seq_MCF-7_Human	0.96192488
78	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.95055622
79	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.93364942
80	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.92311898
81	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.91010424
82	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.90540580
83	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.90409681
84	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.88692360
85	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.88503346
86	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.88407992
87	HTT_18923047_ChIP-ChIP_STHdh_Human	0.86289024
88	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.85926218
89	CBP_20019798_ChIP-Seq_JUKART_Human	0.82630620
90	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.82630620
91	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.81734702
92	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.81598914
93	BCAT_22108803_ChIP-Seq_LS180_Human	0.80154209
94	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.80020819
95	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.78949837
96	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.77877258
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.77071804
98	GATA3_26560356_Chip-Seq_TH1_Human	0.76236428
99	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.75876798
100	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.74854413

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	4.42092685
2	MP0005377_hearing/vestibular/ear_phenot	4.42092685
3	MP0000569_abnormal_digit_pigmentation	3.83909916
4	MP0008058_abnormal_DNA_repair	3.83669009
5	MP0001984_abnormal_olfaction	3.61918116
6	MP0003567_abnormal_fetal_cardiomyocyte	3.01388978
7	MP0003186_abnormal_redox_activity	2.92270254
8	MP0002102_abnormal_ear_morphology	2.65223205
9	MP0006292_abnormal_olfactory_placode	2.51872418
10	MP0010094_abnormal_chromosome_stability	2.43968694
11	MP0008877_abnormal_DNA_methylation	2.26899983
12	MP0003718_maternal_effect	2.24108591
13	MP0004957_abnormal_blastocyst_morpholog	2.00053864
14	MP0001293_anophthalmia	1.96128007
15	MP0000383_abnormal_hair_follicle	1.94209070
16	MP0003011_delayed_dark_adaptation	1.89235383
17	MP0003806_abnormal_nucleotide_metabolis	1.87769627
18	MP0003693_abnormal_embryo_hatching	1.87039966
19	MP0002736_abnormal_nociception_after	1.81651537
20	MP0005645_abnormal_hypothalamus_physiol	1.73625185
21	MP0002160_abnormal_reproductive_system	1.71450493
22	MP0009697_abnormal_copulation	1.70132557
23	MP0008995_early_reproductive_senescence	1.63523637
24	MP0005084_abnormal_gallbladder_morpholo	1.60745481
25	MP0004742_abnormal_vestibular_system	1.60717182
26	MP0002234_abnormal_pharynx_morphology	1.60484131
27	MP0003315_abnormal_perineum_morphology	1.57578121
28	MP0008789_abnormal_olfactory_epithelium	1.56957207
29	MP0001485_abnormal_pinna_reflex	1.56643588
30	MP0008260_abnormal_autophagy	1.56375905
31	MP0002277_abnormal_respiratory_mucosa	1.54041004
32	MP0001188_hyperpigmentation	1.52358205
33	MP0000427_abnormal_hair_cycle	1.50019220
34	MP0002938_white_spotting	1.47257044
35	MP0010678_abnormal_skin_adnexa	1.43243933
36	MP0008007_abnormal_cellular_replicative	1.42147604
37	MP0005551_abnormal_eye_electrophysiolog	1.37545446
38	MP0002138_abnormal_hepatobiliary_system	1.36875483
39	MP0003077_abnormal_cell_cycle	1.34346803
40	MP0003786_premature_aging	1.30804417
41	MP0001929_abnormal_gametogenesis	1.29219959
42	MP0008057_abnormal_DNA_replication	1.29109571
43	MP0002210_abnormal_sex_determination	1.25645383
44	MP0004215_abnormal_myocardial_fiber	1.23110120
45	MP0006036_abnormal_mitochondrial_physio	1.20362963
46	MP0003119_abnormal_digestive_system	1.17649605
47	MP0001145_abnormal_male_reproductive	1.14785266
48	MP0003111_abnormal_nucleus_morphology	1.14397080
49	MP0000631_abnormal_neuroendocrine_gland	1.12669429
50	MP0003283_abnormal_digestive_organ	1.11122212
51	MP0006072_abnormal_retinal_apoptosis	1.09778953
52	MP0005253_abnormal_eye_physiology	1.09502041
53	MP0001968_abnormal_touch/_nociception	1.08442522
54	MP0000653_abnormal_sex_gland	1.07016533
55	MP0003937_abnormal_limbs/digits/tail_de	1.04440823
56	MP0005174_abnormal_tail_pigmentation	1.03770567
57	MP0001119_abnormal_female_reproductive	1.02613220
58	MP0002282_abnormal_trachea_morphology	1.01447756
59	MP0005389_reproductive_system_phenotype	1.00323809
60	MP0002233_abnormal_nose_morphology	0.99125590
61	MP0008932_abnormal_embryonic_tissue	0.98191867
62	MP0001764_abnormal_homeostasis	0.97958492
63	MP0000566_synostosis	0.97439062
64	MP0003698_abnormal_male_reproductive	0.95687485
65	MP0005085_abnormal_gallbladder_physiolo	0.95214978
66	MP0000490_abnormal_crypts_of	0.92855262
67	MP0005636_abnormal_mineral_homeostasis	0.92631318
68	MP0005647_abnormal_sex_gland	0.89350990
69	MP0008873_increased_physiological_sensi	0.89272022
70	MP0000343_altered_response_to	0.87741972
71	MP0002095_abnormal_skin_pigmentation	0.86573692
72	MP0000579_abnormal_nail_morphology	0.85724654
73	MP0006035_abnormal_mitochondrial_morpho	0.85712970
74	MP0008004_abnormal_stomach_pH	0.84575930
75	MP0005499_abnormal_olfactory_system	0.83274154
76	MP0005394_taste/olfaction_phenotype	0.83274154
77	MP0000358_abnormal_cell_content/	0.79079879
78	MP0005380_embryogenesis_phenotype	0.76971167
79	MP0001672_abnormal_embryogenesis/_devel	0.76971167
80	MP0008875_abnormal_xenobiotic_pharmacok	0.76879997
81	MP0001905_abnormal_dopamine_level	0.75946945
82	MP0004145_abnormal_muscle_electrophysio	0.73255887
83	MP0006276_abnormal_autonomic_nervous	0.73058933
84	MP0000313_abnormal_cell_death	0.72883580
85	MP0001529_abnormal_vocalization	0.71379154
86	MP0002088_abnormal_embryonic_growth/wei	0.70795156
87	MP0005391_vision/eye_phenotype	0.69650775
88	MP0000647_abnormal_sebaceous_gland	0.68862011
89	MP0001697_abnormal_embryo_size	0.68057049
90	MP0003172_abnormal_lysosome_physiology	0.68006591
91	MP0001879_abnormal_lymphatic_vessel	0.67157998
92	MP0001243_abnormal_dermal_layer	0.67037127
93	MP0009765_abnormal_xenobiotic_induced	0.65914341
94	MP0003984_embryonic_growth_retardation	0.65576169
95	MP0005167_abnormal_blood-brain_barrier	0.64415667
96	MP0002733_abnormal_thermal_nociception	0.63762528
97	MP0002653_abnormal_ependyma_morphology	0.63207189
98	MP0001486_abnormal_startle_reflex	0.63121135
99	MP0003638_abnormal_response/metabolism_	0.62706294
100	MP0003936_abnormal_reproductive_system	0.62124476

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal hemoglobin (HP:0011902)	6.67712402
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.62679635
3	Chromsome breakage (HP:0040012)	4.15986740
4	Tubulointerstitial nephritis (HP:0001970)	4.13210189
5	Acute necrotizing encephalopathy (HP:0006965)	3.96875878
6	Hepatocellular necrosis (HP:0001404)	3.89420941
7	Mitochondrial inheritance (HP:0001427)	3.85948460
8	Progressive macrocephaly (HP:0004481)	3.85787263
9	Aplastic anemia (HP:0001915)	3.81035605
10	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.64911322
11	Increased CSF lactate (HP:0002490)	3.64016685
12	Type I transferrin isoform profile (HP:0003642)	3.56763669
13	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.49591206
14	Abnormal protein N-linked glycosylation (HP:0012347)	3.49591206
15	Abnormal protein glycosylation (HP:0012346)	3.49591206
16	Abnormal glycosylation (HP:0012345)	3.49591206
17	Abnormal mitochondria in muscle tissue (HP:0008316)	3.46524173
18	Hepatic necrosis (HP:0002605)	3.34812363
19	Bilateral microphthalmos (HP:0007633)	3.22814092
20	Acute encephalopathy (HP:0006846)	3.12218663
21	Congenital primary aphakia (HP:0007707)	3.05157059
22	Gait imbalance (HP:0002141)	2.93100189
23	Medial flaring of the eyebrow (HP:0010747)	2.92163502
24	Abnormality of midbrain morphology (HP:0002418)	2.87267599
25	Molar tooth sign on MRI (HP:0002419)	2.87267599
26	Nephroblastoma (Wilms tumor) (HP:0002667)	2.82780340
27	Lipid accumulation in hepatocytes (HP:0006561)	2.80770929
28	Nephrogenic diabetes insipidus (HP:0009806)	2.77836156
29	Increased serum pyruvate (HP:0003542)	2.75793312
30	Abnormality of glycolysis (HP:0004366)	2.65104073
31	Embryonal renal neoplasm (HP:0011794)	2.61274879
32	Increased hepatocellular lipid droplets (HP:0006565)	2.59977441
33	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.56401535
34	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.56401535
35	Methylmalonic acidemia (HP:0002912)	2.53929082
36	Cerebral edema (HP:0002181)	2.49370154
37	Medulloblastoma (HP:0002885)	2.46735031
38	Vaginal atresia (HP:0000148)	2.35832036
39	Nephronophthisis (HP:0000090)	2.35001433
40	Pancytopenia (HP:0001876)	2.34717523
41	Gout (HP:0001997)	2.34587049
42	Median cleft lip (HP:0000161)	2.32780804
43	Respiratory failure (HP:0002878)	2.31653280
44	Meckel diverticulum (HP:0002245)	2.31031113
45	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.27398209
46	Abnormal number of incisors (HP:0011064)	2.26038877
47	Lactic acidosis (HP:0003128)	2.25157739
48	Renal Fanconi syndrome (HP:0001994)	2.23589523
49	Genital tract atresia (HP:0001827)	2.22990012
50	Abnormality of DNA repair (HP:0003254)	2.22494029
51	Adenoma sebaceum (HP:0009720)	2.19956028
52	Angiofibromas (HP:0010615)	2.19956028
53	Increased serum lactate (HP:0002151)	2.18633761
54	Colon cancer (HP:0003003)	2.17918258
55	CNS demyelination (HP:0007305)	2.12983009
56	Supernumerary bones of the axial skeleton (HP:0009144)	2.12184457
57	Hypoplasia of the pons (HP:0012110)	2.11830049
58	Abnormality of the ileum (HP:0001549)	2.09097239
59	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.06959776
60	Broad distal phalanx of finger (HP:0009836)	2.06039588
61	Methylmalonic aciduria (HP:0012120)	1.99054388
62	Pendular nystagmus (HP:0012043)	1.98759070
63	Pancreatic cysts (HP:0001737)	1.96809491
64	Neonatal respiratory distress (HP:0002643)	1.95032195
65	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.94850903
66	Biliary tract neoplasm (HP:0100574)	1.94286435
67	Megalencephaly (HP:0001355)	1.93478940
68	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.93209433
69	Congenital, generalized hypertrichosis (HP:0004540)	1.93086849
70	Abnormal number of erythroid precursors (HP:0012131)	1.92674109
71	Optic disc pallor (HP:0000543)	1.92099743
72	Exercise intolerance (HP:0003546)	1.90805489
73	Poor coordination (HP:0002370)	1.88891638
74	Abnormality of the pons (HP:0007361)	1.87681478
75	Scotoma (HP:0000575)	1.84725350
76	Lethargy (HP:0001254)	1.84230939
77	High anterior hairline (HP:0009890)	1.83384489
78	X-linked dominant inheritance (HP:0001423)	1.83091477
79	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.82705190
80	Dicarboxylic aciduria (HP:0003215)	1.82705190
81	Spontaneous abortion (HP:0005268)	1.81925871
82	Abnormality of chromosome stability (HP:0003220)	1.81345383
83	Opisthotonus (HP:0002179)	1.81004129
84	Multiple enchondromatosis (HP:0005701)	1.79786781
85	Abnormality of the renal medulla (HP:0100957)	1.78536115
86	Abnormality of vitamin B metabolism (HP:0004340)	1.78069109
87	Generalized aminoaciduria (HP:0002909)	1.78013365
88	Increased IgM level (HP:0003496)	1.77582713
89	Central scotoma (HP:0000603)	1.75636521
90	Small intestinal stenosis (HP:0012848)	1.75143302
91	Duodenal stenosis (HP:0100867)	1.75143302
92	Myokymia (HP:0002411)	1.74932235
93	Short nail (HP:0001799)	1.73833297
94	Confusion (HP:0001289)	1.73608668
95	Reduced antithrombin III activity (HP:0001976)	1.72145009
96	Exertional dyspnea (HP:0002875)	1.70488328
97	Abnormality of the preputium (HP:0100587)	1.68191656
98	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.66427222
99	Abnormality of the prostate (HP:0008775)	1.65901274
100	Horizontal nystagmus (HP:0000666)	1.65784181

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.78080110
2	TAF1	3.59422887
3	PNCK	3.43577315
4	PLK4	3.37424742
5	MST4	3.36608306
6	PBK	3.35034691
7	MKNK1	2.92491373
8	CDC7	2.87333087
9	TSSK6	2.77624412
10	NEK1	2.42105175
11	BCKDK	2.41700328
12	SRPK1	2.23097560
13	BUB1	1.97499763
14	CASK	1.94090839
15	MAPKAPK5	1.77355901
16	DYRK2	1.63059146
17	WEE1	1.62803462
18	MET	1.62312648
19	MAP3K12	1.61895529
20	CAMK1G	1.61151179
21	MKNK2	1.59602004
22	VRK1	1.55604594
23	CSNK1A1L	1.51069704
24	NUAK1	1.49982467
25	DAPK1	1.42007914
26	CCNB1	1.36733301
27	DAPK2	1.36553027
28	NME2	1.36113516
29	CDK8	1.34215291
30	NME1	1.30130647
31	TNIK	1.29039969
32	OXSR1	1.28375069
33	EIF2AK1	1.23267876
34	PTK2B	1.22024122
35	FGR	1.21745061
36	TXK	1.20877915
37	CSNK1G3	1.14092084
38	PLK2	1.11430236
39	STK16	1.05157659
40	CSNK1G2	1.01769992
41	PLK1	0.98056064
42	CSNK1G1	0.97662713
43	PDK2	0.94982650
44	MAP2K4	0.94219335
45	PLK3	0.91771763
46	ZAK	0.90568003
47	WNK3	0.90262702
48	MAP3K5	0.88772829
49	MAP2K3	0.88523669
50	GRK1	0.84810137
51	NEK2	0.84253523
52	PINK1	0.84250693
53	ATR	0.83163311
54	BMPR1B	0.82849666
55	AURKB	0.79502868
56	CDK19	0.78871914
57	CSF1R	0.77441582
58	PASK	0.77382874
59	EIF2AK3	0.76385876
60	MYLK	0.70997376
61	TRIM28	0.70688669
62	MAP2K6	0.64870428
63	TTK	0.64612754
64	ATM	0.61208800
65	BMX	0.59123456
66	NEK9	0.56676955
67	ADRBK2	0.54315497
68	CDK7	0.53852291
69	DAPK3	0.51560126
70	RPS6KA5	0.51263219
71	MAP3K6	0.50526224
72	MAP3K4	0.49411515
73	ADRBK1	0.49166980
74	KIT	0.48041371
75	TAOK3	0.47482886
76	PHKG2	0.43427346
77	PHKG1	0.43427346
78	FGFR1	0.42344774
79	CSNK2A2	0.41134960
80	EGFR	0.40721048
81	BCR	0.40085470
82	ABL2	0.39511766
83	STK38L	0.38096708
84	CSNK2A1	0.37978434
85	RPS6KB1	0.36848731
86	CHEK1	0.36782389
87	PRKCQ	0.35050563
88	CHEK2	0.34328012
89	IGF1R	0.33546758
90	MINK1	0.33299851
91	SCYL2	0.33173508
92	CAMK2A	0.32975520
93	CSNK1E	0.32906423
94	PIK3CG	0.31421343
95	TEC	0.30860810
96	AKT2	0.30653854
97	ERBB2	0.30650011
98	CAMK1	0.29878192
99	INSRR	0.27566742
100	CAMK1D	0.27390264

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.55160213
2	Protein export_Homo sapiens_hsa03060	3.49249337
3	Proteasome_Homo sapiens_hsa03050	3.26727765
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.17656828
5	Parkinsons disease_Homo sapiens_hsa05012	3.05869901
6	DNA replication_Homo sapiens_hsa03030	2.95658357
7	RNA degradation_Homo sapiens_hsa03018	2.73070324
8	Homologous recombination_Homo sapiens_hsa03440	2.46600260
9	Mismatch repair_Homo sapiens_hsa03430	2.46021817
10	Propanoate metabolism_Homo sapiens_hsa00640	2.41052279
11	Nucleotide excision repair_Homo sapiens_hsa03420	2.28421647
12	Basal transcription factors_Homo sapiens_hsa03022	2.22979135
13	One carbon pool by folate_Homo sapiens_hsa00670	2.22143262
14	Ribosome_Homo sapiens_hsa03010	2.19555697
15	Pyruvate metabolism_Homo sapiens_hsa00620	2.16186517
16	Huntingtons disease_Homo sapiens_hsa05016	2.11836731
17	RNA polymerase_Homo sapiens_hsa03020	2.11714941
18	Fanconi anemia pathway_Homo sapiens_hsa03460	2.03569736
19	Alzheimers disease_Homo sapiens_hsa05010	1.94628855
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.93468198
21	Pyrimidine metabolism_Homo sapiens_hsa00240	1.86645566
22	Base excision repair_Homo sapiens_hsa03410	1.85667273
23	RNA transport_Homo sapiens_hsa03013	1.80780658
24	Spliceosome_Homo sapiens_hsa03040	1.77567146
25	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.55997361
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.50613537
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.46339128
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.43944158
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.43378778
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.42728988
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.41784088
32	Mineral absorption_Homo sapiens_hsa04978	1.34542444
33	Fatty acid degradation_Homo sapiens_hsa00071	1.32492572
34	Non-homologous end-joining_Homo sapiens_hsa03450	1.22933599
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.21440913
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.21188966
37	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.20673669
38	Purine metabolism_Homo sapiens_hsa00230	1.20231073
39	Folate biosynthesis_Homo sapiens_hsa00790	1.19123116
40	beta-Alanine metabolism_Homo sapiens_hsa00410	1.16389658
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.12816363
42	Butanoate metabolism_Homo sapiens_hsa00650	1.06571235
43	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.01699427
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.94918979
45	Cardiac muscle contraction_Homo sapiens_hsa04260	0.92527928
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.91993085
47	Olfactory transduction_Homo sapiens_hsa04740	0.85932904
48	Cell cycle_Homo sapiens_hsa04110	0.83699750
49	Histidine metabolism_Homo sapiens_hsa00340	0.78677825
50	Regulation of autophagy_Homo sapiens_hsa04140	0.75640068
51	Arginine and proline metabolism_Homo sapiens_hsa00330	0.71580587
52	Steroid biosynthesis_Homo sapiens_hsa00100	0.69829565
53	Metabolic pathways_Homo sapiens_hsa01100	0.68314964
54	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.67827936
55	Sulfur metabolism_Homo sapiens_hsa00920	0.65375064
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.65349283
57	Peroxisome_Homo sapiens_hsa04146	0.65191193
58	Oocyte meiosis_Homo sapiens_hsa04114	0.65073208
59	mRNA surveillance pathway_Homo sapiens_hsa03015	0.64440309
60	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.62889456
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.62761445
62	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.62189432
63	Glutathione metabolism_Homo sapiens_hsa00480	0.60792615
64	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.60681315
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59018273
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57454224
67	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.57321304
68	Fatty acid elongation_Homo sapiens_hsa00062	0.55640792
69	Selenocompound metabolism_Homo sapiens_hsa00450	0.55306169
70	Carbon metabolism_Homo sapiens_hsa01200	0.53346037
71	Retinol metabolism_Homo sapiens_hsa00830	0.51058147
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.50451714
73	Sulfur relay system_Homo sapiens_hsa04122	0.48743858
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.47517453
75	Lysine degradation_Homo sapiens_hsa00310	0.45840543
76	Caffeine metabolism_Homo sapiens_hsa00232	0.45047161
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44801984
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.44213795
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.43842461
80	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.42436234
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42349464
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.41471266
83	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.41223190
84	Tyrosine metabolism_Homo sapiens_hsa00350	0.39868040
85	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.39484977
86	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.39279876
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38626808
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38416439
89	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.37343958
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.35269533
91	Phototransduction_Homo sapiens_hsa04744	0.34819044
92	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33718403
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.32454015
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.30238244
95	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.28324025
96	Primary immunodeficiency_Homo sapiens_hsa05340	0.24769702
97	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.21458307
98	PPAR signaling pathway_Homo sapiens_hsa03320	0.20207278
99	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.19962929
100	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.18427808

CKS1BP7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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