CLASP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.38683648
2regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.26927293
3cardiac myofibril assembly (GO:0055003)5.25039190
4negative regulation of potassium ion transmembrane transport (GO:1901380)4.98211053
5regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.78289164
6regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.75939077
7sarcomere organization (GO:0045214)4.52162144
8cardiac muscle contraction (GO:0060048)4.30435154
9myofibril assembly (GO:0030239)4.27449691
10paraxial mesoderm development (GO:0048339)4.10325164
11cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.06892767
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.98449975
13adult heart development (GO:0007512)3.97548272
14plasma membrane repair (GO:0001778)3.91084805
15cell communication by electrical coupling (GO:0010644)3.89767482
16pyrimidine nucleobase catabolic process (GO:0006208)3.82237542
17regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.79519248
18regulation of relaxation of muscle (GO:1901077)3.75306876
19cell communication involved in cardiac conduction (GO:0086065)3.71642460
20postsynaptic membrane organization (GO:0001941)3.67450150
21presynaptic membrane assembly (GO:0097105)3.67156666
22regulation of skeletal muscle contraction (GO:0014819)3.52244214
23regulation of actin filament-based movement (GO:1903115)3.50521613
24presynaptic membrane organization (GO:0097090)3.44895226
25regulation of cell communication by electrical coupling (GO:0010649)3.43580583
26regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.41749831
27cardiac muscle hypertrophy (GO:0003300)3.41365491
28ventricular cardiac muscle cell action potential (GO:0086005)3.39591349
29regulation of membrane repolarization (GO:0060306)3.38593787
30cardiac muscle cell development (GO:0055013)3.33568584
31positive regulation of dendritic spine morphogenesis (GO:0061003)3.30046549
32muscle filament sliding (GO:0030049)3.28073527
33actin-myosin filament sliding (GO:0033275)3.28073527
34regulation of sarcomere organization (GO:0060297)3.27702439
35nucleus localization (GO:0051647)3.22411463
36striated muscle hypertrophy (GO:0014897)3.21547558
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.19842016
38cardiac cell development (GO:0055006)3.19436287
39negative regulation of organelle assembly (GO:1902116)3.14913282
40neurotransmitter-gated ion channel clustering (GO:0072578)3.13931818
41actomyosin structure organization (GO:0031032)3.13605605
42prostate gland growth (GO:0060736)3.13525069
43striated muscle contraction (GO:0006941)3.11981665
44layer formation in cerebral cortex (GO:0021819)3.08930521
45cardiac muscle cell action potential (GO:0086001)3.07675718
46embryonic retina morphogenesis in camera-type eye (GO:0060059)3.07242361
47outflow tract septum morphogenesis (GO:0003148)3.04886170
48neuron cell-cell adhesion (GO:0007158)3.04834675
49regulation of striated muscle contraction (GO:0006942)3.04009257
50vocalization behavior (GO:0071625)3.03991661
51cytoplasmic mRNA processing body assembly (GO:0033962)3.03695143
52cerebellar Purkinje cell differentiation (GO:0021702)2.99760881
53neuron recognition (GO:0008038)2.97614409
54negative regulation of cytosolic calcium ion concentration (GO:0051481)2.97359101
55regulation of short-term neuronal synaptic plasticity (GO:0048172)2.96343570
56ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.94486385
57protein localization to synapse (GO:0035418)2.93375276
58neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.92527710
59cardiac muscle tissue morphogenesis (GO:0055008)2.92328316
60establishment of nucleus localization (GO:0040023)2.91359083
61regulation of mitochondrial translation (GO:0070129)2.90606554
62regulation of the force of heart contraction (GO:0002026)2.89277860
63regulation of cardiac muscle contraction (GO:0055117)2.88837258
64dosage compensation (GO:0007549)2.88208712
65positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.87672672
66regulation of NFAT protein import into nucleus (GO:0051532)2.87453767
67nucleobase catabolic process (GO:0046113)2.82804447
68cardiac conduction (GO:0061337)2.82615902
69actin-mediated cell contraction (GO:0070252)2.81455003
70ionotropic glutamate receptor signaling pathway (GO:0035235)2.80999754
71dendrite morphogenesis (GO:0048813)2.80774928
72regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.80120160
73negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.78490719
74regulation of cardiac muscle cell contraction (GO:0086004)2.78377707
75establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.76744020
76mitochondrion transport along microtubule (GO:0047497)2.76744020
77negative regulation of neurotransmitter secretion (GO:0046929)2.76699638
78regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.76241818
79polarized epithelial cell differentiation (GO:0030859)2.75652302
80cell migration in hindbrain (GO:0021535)2.75516084
81synaptic vesicle docking involved in exocytosis (GO:0016081)2.74873731
82regulation of dendritic spine morphogenesis (GO:0061001)2.74789490
83muscle cell cellular homeostasis (GO:0046716)2.74425574
84positive regulation of cardiac muscle cell differentiation (GO:2000727)2.73202555
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.72624466
86sarcoplasmic reticulum calcium ion transport (GO:0070296)2.72457949
87regulation of heart rate (GO:0002027)2.71418420
88cardiac muscle cell action potential involved in contraction (GO:0086002)2.70912503
89negative regulation of potassium ion transport (GO:0043267)2.69775668
90muscle hypertrophy (GO:0014896)2.69163456
91relaxation of cardiac muscle (GO:0055119)2.68601495
92central nervous system neuron axonogenesis (GO:0021955)2.68574512
93regulation of heart rate by cardiac conduction (GO:0086091)2.68272071
94regulation of calcium ion transmembrane transport (GO:1903169)2.66816899
95regulation of calcium ion transmembrane transporter activity (GO:1901019)2.66816899
96regulation of potassium ion transmembrane transporter activity (GO:1901016)2.64971258
97actin filament-based movement (GO:0030048)2.64891950
98vesicle transport along microtubule (GO:0047496)2.63791324
99cardiac chamber formation (GO:0003207)2.63628175
100activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.62625195
101regulation of synaptic vesicle exocytosis (GO:2000300)2.62371303
102positive regulation of synapse maturation (GO:0090129)2.62214648
103interkinetic nuclear migration (GO:0022027)2.61937573
104synaptic vesicle maturation (GO:0016188)2.61701983
105positive regulation of potassium ion transmembrane transport (GO:1901381)2.61611216
106heart trabecula formation (GO:0060347)2.61412998
107embryonic camera-type eye morphogenesis (GO:0048596)2.58869599
108auditory behavior (GO:0031223)2.58663320
109muscle tissue morphogenesis (GO:0060415)2.58655561
110nerve growth factor signaling pathway (GO:0038180)2.58142529
111positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.57830812
112opioid receptor signaling pathway (GO:0038003)2.57626251
113dendritic spine morphogenesis (GO:0060997)2.57369596
114neuronal action potential propagation (GO:0019227)2.56787823
115myotube differentiation (GO:0014902)2.55581573
116retina vasculature morphogenesis in camera-type eye (GO:0061299)2.54886851
117establishment or maintenance of monopolar cell polarity (GO:0061339)2.54698043
118establishment of monopolar cell polarity (GO:0061162)2.54698043
119basement membrane organization (GO:0071711)2.53611849
120bundle of His cell to Purkinje myocyte communication (GO:0086069)2.52763798
121histone H3-K4 trimethylation (GO:0080182)2.52192252
122negative regulation of striated muscle cell apoptotic process (GO:0010664)2.51496129
123organelle transport along microtubule (GO:0072384)2.50427011
124atrial septum morphogenesis (GO:0060413)2.50143728
125heart morphogenesis (GO:0003007)2.48737471
126receptor recycling (GO:0001881)2.47924516
127early endosome to late endosome transport (GO:0045022)2.47791910
128regulation of potassium ion transmembrane transport (GO:1901379)2.47627664
129glutamate secretion (GO:0014047)2.47484662
130bone trabecula formation (GO:0060346)2.45723784
131positive regulation of dendrite morphogenesis (GO:0050775)2.45535823
132central nervous system projection neuron axonogenesis (GO:0021952)2.45108064
133neuromuscular synaptic transmission (GO:0007274)2.44929542
134epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.44667511
135membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.43269277
136axonal fasciculation (GO:0007413)2.42009914
137mitochondrion localization (GO:0051646)2.41842139
138regulation of glutamate receptor signaling pathway (GO:1900449)2.40463597
139synapse assembly (GO:0007416)2.40136592
140cerebellar granule cell differentiation (GO:0021707)2.38839447
141regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.37374396
142establishment of mitochondrion localization (GO:0051654)2.36520942
143negative regulation of neurotransmitter transport (GO:0051589)2.36123270
144cerebral cortex radially oriented cell migration (GO:0021799)2.34832535
145cell differentiation in hindbrain (GO:0021533)2.33304356
146axon extension (GO:0048675)2.33263786
147regulation of dendritic spine development (GO:0060998)2.32273870
148neuronal ion channel clustering (GO:0045161)2.32184512
149positive regulation of dendritic spine development (GO:0060999)2.31644725
150glutamate receptor signaling pathway (GO:0007215)2.31576070
151gamma-aminobutyric acid transport (GO:0015812)2.29820963
152regulation of axon guidance (GO:1902667)2.29479005
153response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.28459899
154regulation of synapse maturation (GO:0090128)2.28096838
155regulation of dendrite morphogenesis (GO:0048814)2.28006341
156membrane assembly (GO:0071709)2.27926662
157spinal cord development (GO:0021510)2.26951265
158regulation of axon extension involved in axon guidance (GO:0048841)2.25265905
159regulation of synapse assembly (GO:0051963)2.25244598
160myoblast fusion (GO:0007520)2.25156971
161negative regulation of dendrite development (GO:2000171)2.24579088
162hippocampus development (GO:0021766)2.24199227
163exploration behavior (GO:0035640)2.24121841
164regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.23552268
165locomotory exploration behavior (GO:0035641)2.23027702
166cardiac muscle hypertrophy in response to stress (GO:0014898)2.22861004
167muscle hypertrophy in response to stress (GO:0003299)2.22861004
168cardiac muscle adaptation (GO:0014887)2.22861004
169regulation of skeletal muscle cell differentiation (GO:2001014)2.22771174
170synapse organization (GO:0050808)2.22196243
171limb bud formation (GO:0060174)2.22169261
172membrane depolarization during action potential (GO:0086010)2.22129951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.04318823
2DROSHA_22980978_ChIP-Seq_HELA_Human2.48969390
3* EP300_21415370_ChIP-Seq_HL-1_Mouse2.26326082
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.21841802
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.19499543
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17924189
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.13070623
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.08577848
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04990919
10GBX2_23144817_ChIP-Seq_PC3_Human2.00434225
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.00052421
12RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99921122
13EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99921122
14* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.99051063
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.96344344
16RNF2_27304074_Chip-Seq_ESCs_Mouse1.91826448
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82620394
18TAF15_26573619_Chip-Seq_HEK293_Human1.81924811
19IGF1R_20145208_ChIP-Seq_DFB_Human1.80670072
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76759847
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74234924
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74023060
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73787682
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.73717065
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72803096
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71544980
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67330772
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63213793
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61958492
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61411288
31* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60949379
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59959490
33TP53_16413492_ChIP-PET_HCT116_Human1.59218134
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58546991
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58432558
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.58090940
37BCAT_22108803_ChIP-Seq_LS180_Human1.56432297
38AHR_22903824_ChIP-Seq_MCF-7_Human1.56114475
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54912150
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54459024
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.53727864
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.51187141
43* ISL1_27105846_Chip-Seq_CPCs_Mouse1.50104909
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50082782
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.49719469
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49221878
47* RING1B_27294783_Chip-Seq_ESCs_Mouse1.48478213
48AR_21572438_ChIP-Seq_LNCaP_Human1.46507890
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.44987070
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42246239
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42024462
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.41804375
53YAP1_20516196_ChIP-Seq_MESCs_Mouse1.41196086
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39776440
55AR_19668381_ChIP-Seq_PC3_Human1.39433173
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39057453
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38771274
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38663205
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.37797580
60FUS_26573619_Chip-Seq_HEK293_Human1.37668211
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37142102
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36643977
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36605574
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36282898
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35683272
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35683272
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34557114
68* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34473004
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.32869267
70RNF2_27304074_Chip-Seq_NSC_Mouse1.32805831
71SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32365018
72RXR_22108803_ChIP-Seq_LS180_Human1.32180414
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.30954533
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.29846831
75* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28494256
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27086912
77* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26766775
78SMAD4_21741376_ChIP-Seq_HESCs_Human1.26729312
79EGR1_19374776_ChIP-ChIP_THP-1_Human1.25635754
80* TBX20_22328084_ChIP-Seq_HEART_Mouse1.24921557
81* TBX20_22080862_ChIP-Seq_HEART_Mouse1.24921557
82KDM2B_26808549_Chip-Seq_K562_Human1.24601515
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.23426527
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.23153693
85STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23033476
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22774137
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22517512
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21651206
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20585832
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20133135
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19811555
92* SOX9_26525672_Chip-Seq_HEART_Mouse1.19645432
93ZNF274_21170338_ChIP-Seq_K562_Hela1.19569149
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19216323
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18599960
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17353771
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16978856
98* NANOG_18555785_Chip-Seq_ESCs_Mouse1.16361554
99REST_21632747_ChIP-Seq_MESCs_Mouse1.16267518
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16151476
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14282298
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14258939
103STAT3_23295773_ChIP-Seq_U87_Human1.14219899
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13094995
105KDM2B_26808549_Chip-Seq_REH_Human1.11171257
106REST_18959480_ChIP-ChIP_MESCs_Mouse1.10398656
107* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09724844
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09497935
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.09136821
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08468080
111TP53_20018659_ChIP-ChIP_R1E_Mouse1.07157876
112TP53_18474530_ChIP-ChIP_U2OS_Human1.07096608
113TCF4_23295773_ChIP-Seq_U87_Human1.05960257
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05173475
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04178956
116RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02364509
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00825585
118BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00568803
119P300_19829295_ChIP-Seq_ESCs_Human0.98363307
120FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98186757
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97336427
122OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96841581
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95751978
124* RUNX2_22187159_ChIP-Seq_PCA_Human0.95581848
125TCF4_18268006_ChIP-ChIP_LS174T_Human0.95298783
126P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94818308
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94367113
128AR_25329375_ChIP-Seq_VCAP_Human0.93650343
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90849319
130POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90505099
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90380133
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90315935

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy4.34721798
2MP0002837_dystrophic_cardiac_calcinosis3.93889645
3MP0004084_abnormal_cardiac_muscle3.89234467
4MP0004215_abnormal_myocardial_fiber3.55896162
5MP0003941_abnormal_skin_development3.06612382
6MP0000566_synostosis2.96882233
7MP0005248_abnormal_Harderian_gland2.81108230
8MP0003646_muscle_fatigue2.64622205
9MP0001346_abnormal_lacrimal_gland2.63906579
10MP0003787_abnormal_imprinting2.47236701
11MP0005423_abnormal_somatic_nervous2.42345960
12MP0003137_abnormal_impulse_conducting2.36352869
13MP0004036_abnormal_muscle_relaxation2.30747193
14MP0008775_abnormal_heart_ventricle2.21067450
15MP0003705_abnormal_hypodermis_morpholog2.17626648
16MP0005330_cardiomyopathy2.16868589
17MP0000749_muscle_degeneration2.02162214
18MP0005409_darkened_coat_color2.01935942
19MP0004859_abnormal_synaptic_plasticity2.00737617
20MP0005623_abnormal_meninges_morphology2.00040814
21MP0002972_abnormal_cardiac_muscle1.98356623
22MP0004087_abnormal_muscle_fiber1.94581534
23MP0004145_abnormal_muscle_electrophysio1.87839936
24MP0004272_abnormal_basement_membrane1.85239985
25MP0002822_catalepsy1.81579704
26MP0010630_abnormal_cardiac_muscle1.81012120
27MP0003950_abnormal_plasma_membrane1.80128194
28MP0005620_abnormal_muscle_contractility1.72199153
29MP0000579_abnormal_nail_morphology1.69908099
30MP0003828_pulmonary_edema1.68912199
31MP0002269_muscular_atrophy1.68810312
32MP0006138_congestive_heart_failure1.66218828
33MP0001486_abnormal_startle_reflex1.60615236
34MP0002734_abnormal_mechanical_nocicepti1.60511094
35MP0001544_abnormal_cardiovascular_syste1.60071145
36MP0005385_cardiovascular_system_phenoty1.60071145
37MP0001984_abnormal_olfaction1.56501062
38MP0004484_altered_response_of1.56195510
39MP0004085_abnormal_heartbeat1.55164452
40MP0000569_abnormal_digit_pigmentation1.54994563
41MP0008569_lethality_at_weaning1.52528127
42MP0002106_abnormal_muscle_physiology1.51032665
43MP0002127_abnormal_cardiovascular_syste1.43759828
44MP0000427_abnormal_hair_cycle1.42275057
45MP0002064_seizures1.38165896
46MP0003890_abnormal_embryonic-extraembry1.37014074
47MP0002572_abnormal_emotion/affect_behav1.36412233
48MP0000750_abnormal_muscle_regeneration1.35321881
49MP0002272_abnormal_nervous_system1.34591996
50MP0004885_abnormal_endolymph1.34228389
51MP0000759_abnormal_skeletal_muscle1.32556507
52MP0004233_abnormal_muscle_weight1.32256939
53MP0006276_abnormal_autonomic_nervous1.29826520
54MP0005369_muscle_phenotype1.29411813
55MP0003121_genomic_imprinting1.27291284
56MP0000733_abnormal_muscle_development1.22310810
57MP0002067_abnormal_sensory_capabilities1.20473857
58MP0003045_fibrosis1.19173338
59MP0003385_abnormal_body_wall1.18135688
60MP0004130_abnormal_muscle_cell1.16389567
61MP0005386_behavior/neurological_phenoty1.15727522
62MP0004924_abnormal_behavior1.15727522
63MP0000778_abnormal_nervous_system1.13592798
64MP0003567_abnormal_fetal_cardiomyocyte1.13358181
65MP0004510_myositis1.12956923
66MP0004858_abnormal_nervous_system1.12325368
67MP0005379_endocrine/exocrine_gland_phen1.10189470
68MP0000747_muscle_weakness1.09934579
69MP0000383_abnormal_hair_follicle1.09377656
70MP0004134_abnormal_chest_morphology1.08291124
71MP0005670_abnormal_white_adipose1.07322317
72MP0005503_abnormal_tendon_morphology1.07077968
73MP0008057_abnormal_DNA_replication1.03413104
74MP0001177_atelectasis1.02873697
75MP0005645_abnormal_hypothalamus_physiol1.01669983
76MP0002108_abnormal_muscle_morphology1.00981316
77MP0002081_perinatal_lethality1.00813320
78MP0000631_abnormal_neuroendocrine_gland1.00576852
79MP0000534_abnormal_ureter_morphology0.99985443
80MP0005187_abnormal_penis_morphology0.99919640
81MP0000266_abnormal_heart_morphology0.99584118
82MP0002009_preneoplasia0.97163001
83MP0001502_abnormal_circadian_rhythm0.96903567
84MP0003880_abnormal_central_pattern0.95896258
85MP0003755_abnormal_palate_morphology0.95553527
86MP0003635_abnormal_synaptic_transmissio0.94462889
87MP0002066_abnormal_motor_capabilities/c0.92540752
88MP0002063_abnormal_learning/memory/cond0.92532879
89MP0004142_abnormal_muscle_tone0.92485318
90MP0002925_abnormal_cardiovascular_devel0.92191452
91MP0003935_abnormal_craniofacial_develop0.91594041
92MP0004264_abnormal_extraembryonic_tissu0.91226371
93MP0002752_abnormal_somatic_nervous0.90647821
94MP0005646_abnormal_pituitary_gland0.89964786
95MP0004270_analgesia0.89332901
96MP0004197_abnormal_fetal_growth/weight/0.89253697
97MP0003942_abnormal_urinary_system0.87990240
98MP0003566_abnormal_cell_adhesion0.87713269
99MP0009046_muscle_twitch0.85578851
100MP0002234_abnormal_pharynx_morphology0.85333152
101MP0003122_maternal_imprinting0.85238934
102MP0002638_abnormal_pupillary_reflex0.84691299
103MP0001943_abnormal_respiration0.84070623
104MP0001879_abnormal_lymphatic_vessel0.83636859
105MP0008877_abnormal_DNA_methylation0.83186912
106MP0002697_abnormal_eye_size0.82705869
107MP0009780_abnormal_chondrocyte_physiolo0.81235406
108MP0001293_anophthalmia0.80700936
109MP0001299_abnormal_eye_distance/0.79626707
110MP0005394_taste/olfaction_phenotype0.79397725
111MP0005499_abnormal_olfactory_system0.79397725
112MP0002184_abnormal_innervation0.79352965
113MP0003861_abnormal_nervous_system0.79163059
114MP0002557_abnormal_social/conspecific_i0.77704544
115MP0003119_abnormal_digestive_system0.77581387
116MP0002735_abnormal_chemical_nociception0.75895534
117MP0000428_abnormal_craniofacial_morphol0.75325555
118MP0010769_abnormal_survival0.75077680
119MP0001968_abnormal_touch/_nociception0.74714134
120MP0009703_decreased_birth_body0.74508424
121MP0002116_abnormal_craniofacial_bone0.74384983
122MP0010770_preweaning_lethality0.74318959
123MP0002082_postnatal_lethality0.74318959
124MP0005171_absent_coat_pigmentation0.73987393
125MP0005076_abnormal_cell_differentiation0.72826072
126MP0010386_abnormal_urinary_bladder0.71471814
127MP0003937_abnormal_limbs/digits/tail_de0.70978283
128MP0006072_abnormal_retinal_apoptosis0.69388901
129MP0004811_abnormal_neuron_physiology0.69039145
130MP0009745_abnormal_behavioral_response0.67275822
131MP0002152_abnormal_brain_morphology0.65719800
132MP0002896_abnormal_bone_mineralization0.64141529
133MP0002084_abnormal_developmental_patter0.63557713
134MP0005165_increased_susceptibility_to0.63120524
135MP0000955_abnormal_spinal_cord0.62045892
136MP0000537_abnormal_urethra_morphology0.60354161
137MP0003115_abnormal_respiratory_system0.60331513
138MP0002882_abnormal_neuron_morphology0.60108326
139MP0010368_abnormal_lymphatic_system0.59875427
140MP0010352_gastrointestinal_tract_polyps0.58120962
141MP0000681_abnormal_thyroid_gland0.57590757
142MP0003279_aneurysm0.56513983
143MP0005551_abnormal_eye_electrophysiolog0.54682228
144MP0002233_abnormal_nose_morphology0.54297545
145MP0008770_decreased_survivor_rate0.53691421

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.45665371
2Atrial fibrillation (HP:0005110)4.56319856
3Primary atrial arrhythmia (HP:0001692)4.33737249
4Supraventricular tachycardia (HP:0004755)4.08734601
5Hypoplastic ischia (HP:0003175)4.07487260
6Supraventricular arrhythmia (HP:0005115)4.01374421
7Ventricular tachycardia (HP:0004756)3.86499167
8Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.83962127
9Abnormality of the calf musculature (HP:0001430)3.82602824
10Prolonged QT interval (HP:0001657)3.67671257
11Syncope (HP:0001279)3.64303489
12Subaortic stenosis (HP:0001682)3.56450283
13Abnormality of the left ventricular outflow tract (HP:0011103)3.56450283
14Abnormality of the ischium (HP:0003174)3.52521889
15Lower limb amyotrophy (HP:0007210)3.36839825
16Calf muscle hypertrophy (HP:0008981)3.35302114
17Hyporeflexia of lower limbs (HP:0002600)3.27709903
18Oligomenorrhea (HP:0000876)3.16438140
19Abnormality of the labia minora (HP:0012880)3.15157488
20Lipoatrophy (HP:0100578)3.14247407
21Muscle hypertrophy of the lower extremities (HP:0008968)2.93885284
22Exercise-induced myalgia (HP:0003738)2.92622568
23Right ventricular cardiomyopathy (HP:0011663)2.89538596
24Ventricular fibrillation (HP:0001663)2.82076405
25Genetic anticipation (HP:0003743)2.80998355
26Pendular nystagmus (HP:0012043)2.78263676
27Central scotoma (HP:0000603)2.76674932
28Aplasia cutis congenita (HP:0001057)2.76640010
29Exercise-induced muscle cramps (HP:0003710)2.70042521
30Abnormal EKG (HP:0003115)2.68143583
31Drooling (HP:0002307)2.65883834
32Bundle branch block (HP:0011710)2.63456370
33Distal lower limb amyotrophy (HP:0008944)2.60429379
34Muscle fiber splitting (HP:0003555)2.59640691
35Ventricular arrhythmia (HP:0004308)2.57647364
36Focal seizures (HP:0007359)2.54046914
37Abnormality of the pubic bones (HP:0003172)2.44019453
38Atonic seizures (HP:0010819)2.42892446
39Muscle fiber inclusion bodies (HP:0100299)2.42665988
40Progressive cerebellar ataxia (HP:0002073)2.40308713
41Excessive salivation (HP:0003781)2.38124935
42Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.35816309
43Dilated cardiomyopathy (HP:0001644)2.34146913
44Pigmentary retinal degeneration (HP:0001146)2.33928446
45Focal motor seizures (HP:0011153)2.32724962
46Nemaline bodies (HP:0003798)2.29193382
47Horizontal nystagmus (HP:0000666)2.29189647
48Broad metatarsal (HP:0001783)2.26401704
49Urinary bladder sphincter dysfunction (HP:0002839)2.23089376
50EMG: myopathic abnormalities (HP:0003458)2.21637852
51Epileptic encephalopathy (HP:0200134)2.20077660
52Hepatoblastoma (HP:0002884)2.20003608
53Difficulty running (HP:0009046)2.19186713
54Action tremor (HP:0002345)2.18944398
55Shallow orbits (HP:0000586)2.17562952
56Subcapsular cataract (HP:0000523)2.16423987
57Heart block (HP:0012722)2.15058505
58Abnormality of the 4th metacarpal (HP:0010012)2.14229075
59Sparse scalp hair (HP:0002209)2.12292137
60Rib fusion (HP:0000902)2.11182817
61Hyperventilation (HP:0002883)2.11027738
62Type 1 muscle fiber predominance (HP:0003803)2.07953924
63Atrioventricular block (HP:0001678)2.07578255
64Wrist flexion contracture (HP:0001239)2.07372899
65Skull defect (HP:0001362)2.05764730
66Hyperglycemia (HP:0003074)2.04273655
67Aplasia/Hypoplasia of the sternum (HP:0006714)2.03832189
68Short 4th metacarpal (HP:0010044)2.03822242
69Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.03822242
70Dysmetric saccades (HP:0000641)2.02648621
71Hip contracture (HP:0003273)2.01951895
72Elfin facies (HP:0004428)2.00364469
73Mask-like facies (HP:0000298)2.00298767
74Alacrima (HP:0000522)2.00071799
75Cutaneous syndactyly (HP:0012725)1.99371321
76Distal arthrogryposis (HP:0005684)1.98528863
77Distal lower limb muscle weakness (HP:0009053)1.98033790
78Supernumerary ribs (HP:0005815)1.97976162
79Abnormal atrioventricular conduction (HP:0005150)1.97127042
80Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95960982
81Limited hip movement (HP:0008800)1.94010070
82Fetal akinesia sequence (HP:0001989)1.91660017
83Myoglobinuria (HP:0002913)1.91562009
84Chin dimple (HP:0010751)1.90247600
85Impaired vibration sensation in the lower limbs (HP:0002166)1.88218436
86Abnormality of the corticospinal tract (HP:0002492)1.88040549
87Broad-based gait (HP:0002136)1.87752748
88Morphological abnormality of the middle ear (HP:0008609)1.87593882
89Obstructive sleep apnea (HP:0002870)1.87234867
90Scotoma (HP:0000575)1.86703031
91Tracheomalacia (HP:0002779)1.85536803
92Rimmed vacuoles (HP:0003805)1.85088067
93Truncal obesity (HP:0001956)1.84049321
94Hyperacusis (HP:0010780)1.83711098
95Decreased lacrimation (HP:0000633)1.83418945
96Laryngomalacia (HP:0001601)1.83242415
97Increased connective tissue (HP:0009025)1.82629813
98Blue irides (HP:0000635)1.82191399
99Hyperkalemia (HP:0002153)1.82051671
100Volvulus (HP:0002580)1.80716962
101Lower limb muscle weakness (HP:0007340)1.80683165
102Vertebral arch anomaly (HP:0008438)1.80349562
103Scapular winging (HP:0003691)1.77970143
104Overgrowth (HP:0001548)1.77535384
105Exotropia (HP:0000577)1.75412209
106Neoplasm of the oral cavity (HP:0100649)1.75321850
107Insulin-resistant diabetes mellitus (HP:0000831)1.72793143
108Neoplasm of the heart (HP:0100544)1.71911507
109Renovascular hypertension (HP:0100817)1.71874932
110Cystic hygroma (HP:0000476)1.70793942
111Hypoplastic labia majora (HP:0000059)1.70522494
112Round ear (HP:0100830)1.70500479
113Urinary urgency (HP:0000012)1.70133717
114Long eyelashes (HP:0000527)1.70030529
115Supernumerary bones of the axial skeleton (HP:0009144)1.69710301
116Papillary thyroid carcinoma (HP:0002895)1.68936321
117Trigonocephaly (HP:0000243)1.68870836
118Macroorchidism (HP:0000053)1.68780283
119Pointed chin (HP:0000307)1.68033559
120Low posterior hairline (HP:0002162)1.67813126
121Abnormality of the labia majora (HP:0012881)1.67581336
122Abnormality of the lower motor neuron (HP:0002366)1.67450003
123Left ventricular hypertrophy (HP:0001712)1.67423295
124Scanning speech (HP:0002168)1.66640892
125Midline defect of the nose (HP:0004122)1.66102070
126Febrile seizures (HP:0002373)1.65908798
127Myotonia (HP:0002486)1.65554917
128Calcaneovalgus deformity (HP:0001848)1.64479920
129Narrow palate (HP:0000189)1.63937773
130Astrocytoma (HP:0009592)1.63563389
131Abnormality of the astrocytes (HP:0100707)1.63563389
132Spina bifida occulta (HP:0003298)1.63488723
133Open mouth (HP:0000194)1.63065824
134High anterior hairline (HP:0009890)1.63044683
135Neoplasm of the adrenal cortex (HP:0100641)1.62431421
136Dyschromatopsia (HP:0007641)1.62193964
137Cutaneous finger syndactyly (HP:0010554)1.61529671
138Pheochromocytoma (HP:0002666)1.61497121
139Spastic gait (HP:0002064)1.61486320
140Protruding tongue (HP:0010808)1.61058996
141Deeply set eye (HP:0000490)1.60945602
142Abnormality of the foot musculature (HP:0001436)1.60616073
143Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.60378995
144Renal duplication (HP:0000075)1.59849979
145Palmoplantar keratoderma (HP:0000982)1.59216541
146Flat cornea (HP:0007720)1.59006309
147EMG: neuropathic changes (HP:0003445)1.58914434
148Tented upper lip vermilion (HP:0010804)1.58054325
149Abnormality of the parietal bone (HP:0002696)1.57697716
150Epileptiform EEG discharges (HP:0011182)1.57421004
151Gaze-evoked nystagmus (HP:0000640)1.57083205
152Thick eyebrow (HP:0000574)1.56178053
153Abnormality of lateral ventricle (HP:0030047)1.55762396
154Tapered finger (HP:0001182)1.55379212
155Vitreoretinal degeneration (HP:0000655)1.54155869
156Lymphangioma (HP:0100764)1.54099374
157Short chin (HP:0000331)1.52938184
158Asymmetric septal hypertrophy (HP:0001670)1.52584979
159Abnormality of the nasal septum (HP:0000419)1.51856444
160Choroideremia (HP:0001139)1.51786941
161Proximal amyotrophy (HP:0007126)1.51718649
162EEG with generalized epileptiform discharges (HP:0011198)1.51367081
163Aqueductal stenosis (HP:0002410)1.50340167
164Heterotopia (HP:0002282)1.50265197
165Insidious onset (HP:0003587)1.49844116
166Termporal pattern (HP:0011008)1.49844116
167Labial hypoplasia (HP:0000066)1.49829732
168Polar cataract (HP:0010696)1.49730748
169Maternal diabetes (HP:0009800)1.49403605
170Palpitations (HP:0001962)1.49358452
171Obsessive-compulsive behavior (HP:0000722)1.49346244
172Hypoplastic iliac wings (HP:0002866)1.48572876
173Megalencephaly (HP:0001355)1.48472451

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.70971542
2EPHA24.48320271
3TTN3.00077077
4PHKG22.49986856
5PHKG12.49986856
6LMTK22.35590412
7MARK12.31178868
8OBSCN2.17971992
9DMPK2.17501355
10BRD42.12235642
11LATS12.10499141
12AKT32.07206648
13ADRBK21.96821972
14NTRK31.92704551
15PNCK1.86893970
16ICK1.68289129
17KSR11.62574944
18MAP3K41.57830676
19NTRK21.57428140
20EPHB21.54466779
21BCR1.49814124
22INSRR1.49549567
23MAP3K91.43589725
24SIK21.34375391
25SGK21.32967081
26PDGFRA1.32353753
27PRPF4B1.31708769
28CAMK1G1.30431731
29CDC42BPA1.26649335
30STK41.26384707
31PKN21.23053964
32TIE11.22910466
33LATS21.21914546
34RIPK11.19063892
35MINK11.15084730
36PAK31.12123832
37FRK1.10441405
38NEK11.09738196
39UHMK11.09642345
40SGK31.07599086
41MAP3K101.06114498
42SRPK11.05634942
43STK381.03351637
44EPHA31.03104978
45MYLK0.96711150
46ZAK0.96675748
47MAP3K60.95529548
48ERBB30.92918450
49SIK30.89096025
50WNK10.87645151
51EPHA40.86206519
52WNK30.82537913
53PIK3CA0.81272054
54FER0.81094604
55ALK0.79843789
56MAPK100.79150531
57ROCK10.78805819
58SGK2230.78130908
59SGK4940.78130908
60CAMK1D0.77748874
61CSNK1A1L0.77563633
62CSNK1D0.77251636
63STK240.75880779
64PRKD30.75251592
65DYRK1A0.75001754
66CHEK20.74865408
67PDK40.74375809
68PDK30.74375809
69CAMK40.72514483
70EEF2K0.71283861
71PAK60.68244964
72PDGFRB0.68002947
73MAP2K70.67656522
74TNIK0.64852756
75PLK20.64519556
76CCNB10.64233133
77YES10.64111593
78SIK10.64099146
79TRIB30.63056845
80DYRK20.62814157
81CSNK1G20.62775604
82MKNK20.62677319
83MAP3K50.61916149
84CAMK2D0.61881208
85BMPR1B0.61428201
86MAPK130.60686174
87SGK10.60350258
88MTOR0.59411426
89PRKD10.59301273
90FGFR40.59225526
91MAP2K40.56720650
92STK38L0.55925505
93CDK50.55794642
94RPS6KB10.54961370
95ERBB20.54156743
96MAP3K70.54015685
97STK110.53985370
98FGFR30.53955796
99CAMK10.53119106
100PRKAA10.51681298
101PRKCE0.51130426
102DYRK1B0.51117513
103PRKCH0.50737307
104NTRK10.49896132
105MARK20.49749823
106TYRO30.48825288
107FGFR20.48781115
108PIK3CG0.48107773
109FGFR10.47279366
110PKN10.47194677
111PRKAA20.46769973
112PINK10.46640497
113CSNK1G10.46478872
114MAPK120.46268591
115RET0.46172142
116CAMK2B0.46165909
117CHEK10.46136851
118PRKG10.45583382
119STK30.44768532
120PRKCG0.44218643
121* MAPK80.42568720
122GSK3B0.41839097
123CDK40.41476040
124MAPK90.40866279
125CAMKK10.40613289
126NLK0.39334918
127CSNK1E0.39031075
128RPS6KA30.38421428
129CAMK2A0.37737371
130AKT10.36745652
131* ATM0.35688977
132CASK0.34686013
133PRKCB0.33964676

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054143.01609525
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.77553098
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.43700269
4Cardiac muscle contraction_Homo sapiens_hsa042602.10063611
5Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.98511527
6Viral myocarditis_Homo sapiens_hsa054161.89144813
7Notch signaling pathway_Homo sapiens_hsa043301.79799666
8Axon guidance_Homo sapiens_hsa043601.67299048
9Dorso-ventral axis formation_Homo sapiens_hsa043201.63557288
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59518486
11Nicotine addiction_Homo sapiens_hsa050331.57706193
12Circadian rhythm_Homo sapiens_hsa047101.56556119
13Circadian entrainment_Homo sapiens_hsa047131.54439717
14Type II diabetes mellitus_Homo sapiens_hsa049301.40969767
15Olfactory transduction_Homo sapiens_hsa047401.39361158
16Basal cell carcinoma_Homo sapiens_hsa052171.35546254
17Morphine addiction_Homo sapiens_hsa050321.34518986
18Taste transduction_Homo sapiens_hsa047421.32194283
19Adherens junction_Homo sapiens_hsa045201.30236862
20Phototransduction_Homo sapiens_hsa047441.29762891
21cGMP-PKG signaling pathway_Homo sapiens_hsa040221.27900689
22Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27649944
23Lysine degradation_Homo sapiens_hsa003101.25975948
24Oxytocin signaling pathway_Homo sapiens_hsa049211.24903363
25Insulin secretion_Homo sapiens_hsa049111.22911613
26Cholinergic synapse_Homo sapiens_hsa047251.21737720
27Calcium signaling pathway_Homo sapiens_hsa040201.20858699
28Long-term potentiation_Homo sapiens_hsa047201.20839002
29Wnt signaling pathway_Homo sapiens_hsa043101.19398488
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17840771
31Glutamatergic synapse_Homo sapiens_hsa047241.16134281
32Focal adhesion_Homo sapiens_hsa045101.15842371
33Glioma_Homo sapiens_hsa052141.12887530
34Renin secretion_Homo sapiens_hsa049241.12689413
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11944363
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10835369
37ErbB signaling pathway_Homo sapiens_hsa040121.09604840
38Melanogenesis_Homo sapiens_hsa049161.09597975
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08822440
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08492344
41cAMP signaling pathway_Homo sapiens_hsa040241.08422807
42GABAergic synapse_Homo sapiens_hsa047271.07790922
43Inositol phosphate metabolism_Homo sapiens_hsa005621.06465414
44Gastric acid secretion_Homo sapiens_hsa049711.06418124
45mTOR signaling pathway_Homo sapiens_hsa041501.06197426
46MicroRNAs in cancer_Homo sapiens_hsa052061.06090514
47Endometrial cancer_Homo sapiens_hsa052131.05499493
48Hedgehog signaling pathway_Homo sapiens_hsa043401.04963074
49Dopaminergic synapse_Homo sapiens_hsa047281.04919639
50Salivary secretion_Homo sapiens_hsa049701.02504242
51Hippo signaling pathway_Homo sapiens_hsa043901.00745951
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98843042
53Tight junction_Homo sapiens_hsa045300.98510090
54Prolactin signaling pathway_Homo sapiens_hsa049170.97886671
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95378099
56Estrogen signaling pathway_Homo sapiens_hsa049150.94366016
57Insulin signaling pathway_Homo sapiens_hsa049100.93492995
58Gap junction_Homo sapiens_hsa045400.92536286
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92205898
60Proteoglycans in cancer_Homo sapiens_hsa052050.91092062
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90368650
62Non-homologous end-joining_Homo sapiens_hsa034500.88221897
63GnRH signaling pathway_Homo sapiens_hsa049120.87594453
64Amphetamine addiction_Homo sapiens_hsa050310.87454812
65Glucagon signaling pathway_Homo sapiens_hsa049220.84787198
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84100747
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83925189
68Non-small cell lung cancer_Homo sapiens_hsa052230.83787758
69ECM-receptor interaction_Homo sapiens_hsa045120.83728864
70Synaptic vesicle cycle_Homo sapiens_hsa047210.82805517
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.82701365
72Insulin resistance_Homo sapiens_hsa049310.81053260
73Colorectal cancer_Homo sapiens_hsa052100.80743438
74Thyroid hormone synthesis_Homo sapiens_hsa049180.80406381
75Alcoholism_Homo sapiens_hsa050340.79696734
76MAPK signaling pathway_Homo sapiens_hsa040100.77752786
77Renal cell carcinoma_Homo sapiens_hsa052110.76591953
78Rap1 signaling pathway_Homo sapiens_hsa040150.76542580
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76332670
80Long-term depression_Homo sapiens_hsa047300.75311963
81Melanoma_Homo sapiens_hsa052180.74981238
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74051903
83AMPK signaling pathway_Homo sapiens_hsa041520.72953244
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72607912
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72379945
86HIF-1 signaling pathway_Homo sapiens_hsa040660.70449902
87Choline metabolism in cancer_Homo sapiens_hsa052310.69785199
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.69462699
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.68490216
90Serotonergic synapse_Homo sapiens_hsa047260.68434152
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67248053
92Prostate cancer_Homo sapiens_hsa052150.67079706
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67023441
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66182281
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65775151
96Ras signaling pathway_Homo sapiens_hsa040140.65258668
97FoxO signaling pathway_Homo sapiens_hsa040680.64207585
98Chronic myeloid leukemia_Homo sapiens_hsa052200.63474400
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.62664165
100Pancreatic secretion_Homo sapiens_hsa049720.60644861
101Oocyte meiosis_Homo sapiens_hsa041140.60291974
102VEGF signaling pathway_Homo sapiens_hsa043700.60072891
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59480983
104mRNA surveillance pathway_Homo sapiens_hsa030150.58526860
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58424150
106Pathways in cancer_Homo sapiens_hsa052000.58380096
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57915185
108Pancreatic cancer_Homo sapiens_hsa052120.57740084
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57261876
110Small cell lung cancer_Homo sapiens_hsa052220.55921321
111Fatty acid biosynthesis_Homo sapiens_hsa000610.55907256
112Cocaine addiction_Homo sapiens_hsa050300.54508049
113TGF-beta signaling pathway_Homo sapiens_hsa043500.52467625

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