CLASP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.52040499
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.18243514
3neuron cell-cell adhesion (GO:0007158)5.01466873
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.99831917
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.90038871
6vocalization behavior (GO:0071625)4.83859782
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.71527047
8locomotory exploration behavior (GO:0035641)4.66782380
9synaptic vesicle exocytosis (GO:0016079)4.63550925
10neuronal action potential propagation (GO:0019227)4.63372387
11regulation of synaptic vesicle exocytosis (GO:2000300)4.58319130
12protein localization to synapse (GO:0035418)4.54527418
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.43223402
14nucleobase catabolic process (GO:0046113)4.31492681
15glutamate secretion (GO:0014047)4.27534450
16regulation of glutamate receptor signaling pathway (GO:1900449)4.24686279
17dendritic spine morphogenesis (GO:0060997)4.15598281
18layer formation in cerebral cortex (GO:0021819)4.11880601
19regulation of synaptic vesicle transport (GO:1902803)4.08539689
20regulation of synapse structural plasticity (GO:0051823)3.96918020
21glutamate receptor signaling pathway (GO:0007215)3.96185231
22presynaptic membrane assembly (GO:0097105)3.96099775
23neurotransmitter-gated ion channel clustering (GO:0072578)3.95208882
24synaptic transmission, glutamatergic (GO:0035249)3.94357222
25presynaptic membrane organization (GO:0097090)3.93182368
26regulation of neuronal synaptic plasticity (GO:0048168)3.89054730
27neuron recognition (GO:0008038)3.87049418
28exploration behavior (GO:0035640)3.85229153
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.76642354
30dendrite morphogenesis (GO:0048813)3.74688981
31neuron-neuron synaptic transmission (GO:0007270)3.74102404
32postsynaptic membrane organization (GO:0001941)3.74029363
33neurotransmitter secretion (GO:0007269)3.73724062
34axonal fasciculation (GO:0007413)3.72559539
35gamma-aminobutyric acid transport (GO:0015812)3.72500228
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70299237
37synaptic vesicle docking involved in exocytosis (GO:0016081)3.60464703
38auditory behavior (GO:0031223)3.57836314
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.55150393
40transmission of nerve impulse (GO:0019226)3.54330555
41regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.52513061
42long-term memory (GO:0007616)3.51925513
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.51211874
44positive regulation of dendritic spine morphogenesis (GO:0061003)3.47530590
45cellular potassium ion homeostasis (GO:0030007)3.47289675
46response to auditory stimulus (GO:0010996)3.43605002
47positive regulation of membrane potential (GO:0045838)3.40884454
48central nervous system myelination (GO:0022010)3.38949239
49axon ensheathment in central nervous system (GO:0032291)3.38949239
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38589748
51L-amino acid import (GO:0043092)3.37684572
52central nervous system projection neuron axonogenesis (GO:0021952)3.36552455
53adult walking behavior (GO:0007628)3.35994867
54cell migration in hindbrain (GO:0021535)3.34335702
55establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.33685146
56mitochondrion transport along microtubule (GO:0047497)3.33685146
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29879849
58cerebellar Purkinje cell differentiation (GO:0021702)3.29619460
59regulation of postsynaptic membrane potential (GO:0060078)3.29316947
60negative regulation of synaptic transmission, GABAergic (GO:0032229)3.26633283
61synapse assembly (GO:0007416)3.23714823
62neurotransmitter transport (GO:0006836)3.18984642
63response to pheromone (GO:0019236)3.18610691
64positive regulation of dendritic spine development (GO:0060999)3.18297992
65sodium ion export (GO:0071436)3.18256206
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.16663394
67synaptic vesicle endocytosis (GO:0048488)3.16470992
68regulation of dendritic spine morphogenesis (GO:0061001)3.16285802
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16015842
70mechanosensory behavior (GO:0007638)3.15768092
71proline transport (GO:0015824)3.15706739
72gamma-aminobutyric acid signaling pathway (GO:0007214)3.15581218
73regulation of neurotransmitter secretion (GO:0046928)3.14823564
74glycine transport (GO:0015816)3.14122401
75regulation of respiratory system process (GO:0044065)3.14044146
76cerebellar granule cell differentiation (GO:0021707)3.12887555
77positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.12586525
78startle response (GO:0001964)3.12357849
79nerve growth factor signaling pathway (GO:0038180)3.11110383
80establishment of mitochondrion localization (GO:0051654)3.11061770
81neuronal ion channel clustering (GO:0045161)3.10857323
82neuromuscular process controlling posture (GO:0050884)3.09994509
83neuromuscular process controlling balance (GO:0050885)3.08286749
84regulation of synapse maturation (GO:0090128)3.06519625
85neuromuscular synaptic transmission (GO:0007274)3.06145594
86negative regulation of dendrite development (GO:2000171)3.04722524
87regulation of synaptic transmission, glutamatergic (GO:0051966)3.03747508
88regulation of synaptic plasticity (GO:0048167)3.02726142
89negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01599797
90membrane hyperpolarization (GO:0060081)3.00654552
91central nervous system neuron axonogenesis (GO:0021955)3.00556593
92membrane depolarization during action potential (GO:0086010)2.97946377
93positive regulation of synapse maturation (GO:0090129)2.96304270
94regulation of dendritic spine development (GO:0060998)2.95480088
95membrane depolarization (GO:0051899)2.95017056
96learning (GO:0007612)2.93983586
97regulation of synaptic transmission, GABAergic (GO:0032228)2.93402144
98membrane assembly (GO:0071709)2.92867180
99regulation of neurotransmitter transport (GO:0051588)2.91558165
100pyrimidine nucleobase catabolic process (GO:0006208)2.91215812
101long-term synaptic potentiation (GO:0060291)2.89810781
102neurofilament cytoskeleton organization (GO:0060052)2.89460950
103regulation of vesicle fusion (GO:0031338)2.89166048
104negative regulation of neurotransmitter transport (GO:0051589)2.88751203
105regulation of neurotransmitter levels (GO:0001505)2.87930446
106regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.87733501
107prepulse inhibition (GO:0060134)2.87620299
108dendritic spine organization (GO:0097061)2.87354023
109regulation of voltage-gated calcium channel activity (GO:1901385)2.87179504
110regulation of respiratory gaseous exchange (GO:0043576)2.86678640
111cell communication by electrical coupling (GO:0010644)2.85164820
112cerebral cortex radially oriented cell migration (GO:0021799)2.84464466
113organelle transport along microtubule (GO:0072384)2.83468948
114synapse organization (GO:0050808)2.82685497
115positive regulation of synapse assembly (GO:0051965)2.82420623
116negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.81968916
117establishment of nucleus localization (GO:0040023)2.76327088
118regulation of synapse assembly (GO:0051963)2.74394807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.94428843
2* GBX2_23144817_ChIP-Seq_PC3_Human3.78785764
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97700437
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97269235
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83728183
6REST_21632747_ChIP-Seq_MESCs_Mouse2.61115294
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59109264
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59109264
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.55744570
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44390001
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43541817
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40643229
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38246861
14DROSHA_22980978_ChIP-Seq_HELA_Human2.37711853
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34794608
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32110821
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.23726777
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.23080192
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.19509019
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.18142664
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17856619
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11767641
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09255600
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.06009954
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04806001
26AR_21572438_ChIP-Seq_LNCaP_Human1.94780488
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78942389
28TAF15_26573619_Chip-Seq_HEK293_Human1.77211073
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73347995
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72536231
31IGF1R_20145208_ChIP-Seq_DFB_Human1.72476059
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69067898
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66447714
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63946685
35* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58219310
36SMAD4_21799915_ChIP-Seq_A2780_Human1.57447656
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57369067
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55054021
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51875678
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.50653130
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47229577
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46300664
43ZNF274_21170338_ChIP-Seq_K562_Hela1.44234565
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42583519
45P300_19829295_ChIP-Seq_ESCs_Human1.42430581
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41684700
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40689045
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36815867
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.35404920
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33234114
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31451824
52STAT3_23295773_ChIP-Seq_U87_Human1.31240884
53RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29661371
54RNF2_27304074_Chip-Seq_NSC_Mouse1.29075811
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.29020436
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28661528
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28102628
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.27417093
59* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27193524
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27166859
61* SOX2_21211035_ChIP-Seq_LN229_Gbm1.23132628
62AR_25329375_ChIP-Seq_VCAP_Human1.22520562
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22401126
64P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22368648
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.21857916
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21735925
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21550490
68EWS_26573619_Chip-Seq_HEK293_Human1.19230358
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.18025837
70SOX9_26525672_Chip-Seq_HEART_Mouse1.16272860
71AR_19668381_ChIP-Seq_PC3_Human1.15561924
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.15093164
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14914217
74LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14504439
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14365938
76CBP_20019798_ChIP-Seq_JUKART_Human1.14365938
77TCF4_23295773_ChIP-Seq_U87_Human1.14166854
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.13140924
79* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10106668
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.10041671
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09768624
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08915227
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08426691
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08152059
85STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08053384
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07423115
87VDR_22108803_ChIP-Seq_LS180_Human1.06822026
88KDM2B_26808549_Chip-Seq_REH_Human1.06761936
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06504587
90AHR_22903824_ChIP-Seq_MCF-7_Human1.06408058
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05820090
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.04070592
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.03320418
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02565480
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02353226
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02344701
97ER_23166858_ChIP-Seq_MCF-7_Human1.01863685
98* RUNX2_22187159_ChIP-Seq_PCA_Human1.01825407
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00910882
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.00409149
101JUN_21703547_ChIP-Seq_K562_Human0.99146502
102P53_22387025_ChIP-Seq_ESCs_Mouse0.99097943
103NANOG_18555785_Chip-Seq_ESCs_Mouse0.98180143
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97877218
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97877218
106ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97859884
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96577899
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.95547214
109DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95022391
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93639067
111FUS_26573619_Chip-Seq_HEK293_Human0.93118481
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.92533585
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91647001
114KDM2B_26808549_Chip-Seq_K562_Human0.90867000
115* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88477249
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.87634980
117* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87392138
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86735067
119E2F1_18555785_Chip-Seq_ESCs_Mouse0.85232749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.51552648
2MP0003880_abnormal_central_pattern4.65123750
3MP0004270_analgesia3.82241642
4MP0003635_abnormal_synaptic_transmissio3.78746416
5MP0005423_abnormal_somatic_nervous3.30439177
6MP0002063_abnormal_learning/memory/cond3.04548802
7MP0009745_abnormal_behavioral_response3.00716847
8MP0002064_seizures2.94510645
9MP0009046_muscle_twitch2.90896929
10MP0001486_abnormal_startle_reflex2.73874824
11MP0001968_abnormal_touch/_nociception2.72633052
12MP0002734_abnormal_mechanical_nocicepti2.69981257
13MP0002272_abnormal_nervous_system2.57472818
14MP0002572_abnormal_emotion/affect_behav2.54322476
15MP0000778_abnormal_nervous_system2.42642253
16MP0002735_abnormal_chemical_nociception2.17617087
17MP0002733_abnormal_thermal_nociception2.17483627
18MP0002067_abnormal_sensory_capabilities2.08086841
19MP0001440_abnormal_grooming_behavior2.05843428
20MP0001970_abnormal_pain_threshold2.05825072
21MP0008569_lethality_at_weaning1.99430022
22MP0006276_abnormal_autonomic_nervous1.99020288
23MP0002184_abnormal_innervation1.93717365
24MP0002736_abnormal_nociception_after1.90641843
25MP0004885_abnormal_endolymph1.84401047
26MP0002557_abnormal_social/conspecific_i1.84110969
27MP0004924_abnormal_behavior1.82503275
28MP0005386_behavior/neurological_phenoty1.82503275
29MP0000955_abnormal_spinal_cord1.76278581
30MP0003329_amyloid_beta_deposits1.76110729
31MP0004811_abnormal_neuron_physiology1.73179191
32MP0001501_abnormal_sleep_pattern1.71749725
33MP0005645_abnormal_hypothalamus_physiol1.70993007
34MP0001984_abnormal_olfaction1.66191904
35MP0004142_abnormal_muscle_tone1.65602885
36MP0005646_abnormal_pituitary_gland1.63081832
37MP0002882_abnormal_neuron_morphology1.62887627
38MP0002822_catalepsy1.56546779
39MP0001529_abnormal_vocalization1.53978475
40MP0000920_abnormal_myelination1.52783230
41MP0001502_abnormal_circadian_rhythm1.47809619
42MP0004858_abnormal_nervous_system1.45542087
43MP0002066_abnormal_motor_capabilities/c1.45444396
44MP0000569_abnormal_digit_pigmentation1.44710395
45MP0004742_abnormal_vestibular_system1.40290913
46MP0003121_genomic_imprinting1.40229104
47MP0002909_abnormal_adrenal_gland1.35282827
48MP0005551_abnormal_eye_electrophysiolog1.35196805
49MP0001188_hyperpigmentation1.33228055
50MP0001905_abnormal_dopamine_level1.33129906
51MP0003633_abnormal_nervous_system1.32354082
52MP0009780_abnormal_chondrocyte_physiolo1.30509988
53MP0002229_neurodegeneration1.26763237
54MP0003634_abnormal_glial_cell1.25883703
55MP0002152_abnormal_brain_morphology1.24182690
56MP0003787_abnormal_imprinting1.23946808
57MP0004145_abnormal_muscle_electrophysio1.21797427
58MP0003631_nervous_system_phenotype1.20499146
59MP0002638_abnormal_pupillary_reflex1.19141316
60MP0005409_darkened_coat_color1.16764849
61MP0003690_abnormal_glial_cell1.15452822
62MP0003122_maternal_imprinting1.11370800
63MP0005187_abnormal_penis_morphology1.11108729
64MP0000631_abnormal_neuroendocrine_gland1.09445058
65MP0002752_abnormal_somatic_nervous1.06890855
66MP0003632_abnormal_nervous_system1.03545763
67MP0008877_abnormal_DNA_methylation1.01259397
68MP0003879_abnormal_hair_cell1.00709133
69MP0003136_yellow_coat_color1.00515170
70MP0001963_abnormal_hearing_physiology0.99237655
71MP0003137_abnormal_impulse_conducting0.99236542
72MP0006292_abnormal_olfactory_placode0.96615507
73MP0008260_abnormal_autophagy0.96012458
74MP0005171_absent_coat_pigmentation0.91622404
75MP0000751_myopathy0.90728262
76MP0001485_abnormal_pinna_reflex0.89053811
77MP0001177_atelectasis0.88330814
78MP0003890_abnormal_embryonic-extraembry0.86331717
79MP0006072_abnormal_retinal_apoptosis0.85680594
80MP0010386_abnormal_urinary_bladder0.85094790
81MP0001299_abnormal_eye_distance/0.85070693
82MP0005253_abnormal_eye_physiology0.84160324
83MP0002069_abnormal_eating/drinking_beha0.82077022
84MP0005394_taste/olfaction_phenotype0.79835900
85MP0005499_abnormal_olfactory_system0.79835900
86MP0003861_abnormal_nervous_system0.77409715
87MP0004085_abnormal_heartbeat0.76266623
88MP0002234_abnormal_pharynx_morphology0.71087820
89MP0001986_abnormal_taste_sensitivity0.67393783
90MP0000026_abnormal_inner_ear0.67331826
91MP0004133_heterotaxia0.67111460
92MP0002653_abnormal_ependyma_morphology0.66621965
93MP0002081_perinatal_lethality0.65848706
94MP0000015_abnormal_ear_pigmentation0.65807381
95MP0002751_abnormal_autonomic_nervous0.64868654
96MP0003123_paternal_imprinting0.62582853
97MP0003119_abnormal_digestive_system0.62134186
98MP0002090_abnormal_vision0.62115675
99MP0004130_abnormal_muscle_cell0.61309918
100MP0000604_amyloidosis0.60939037
101MP0010769_abnormal_survival0.60464735
102MP0002082_postnatal_lethality0.59159905
103MP0010770_preweaning_lethality0.59159905
104MP0002102_abnormal_ear_morphology0.58089671
105MP0001943_abnormal_respiration0.57472464
106MP0010768_mortality/aging0.56990400
107MP0004215_abnormal_myocardial_fiber0.56201742
108MP0005195_abnormal_posterior_eye0.55812734
109MP0005535_abnormal_body_temperature0.55031170
110MP0004147_increased_porphyrin_level0.54926730
111MP0005248_abnormal_Harderian_gland0.54559490
112MP0004043_abnormal_pH_regulation0.54183197

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.49096151
2Myokymia (HP:0002411)5.78152061
3Focal seizures (HP:0007359)4.86803235
4Epileptic encephalopathy (HP:0200134)4.39670559
5Action tremor (HP:0002345)4.18231484
6Progressive cerebellar ataxia (HP:0002073)4.17808502
7Supranuclear gaze palsy (HP:0000605)4.06539906
8Febrile seizures (HP:0002373)3.99216485
9Visual hallucinations (HP:0002367)3.92935076
10Broad-based gait (HP:0002136)3.86201254
11Ankle clonus (HP:0011448)3.79337213
12Atonic seizures (HP:0010819)3.68412319
13Mutism (HP:0002300)3.30065588
14Gaze-evoked nystagmus (HP:0000640)3.24539779
15Absence seizures (HP:0002121)3.22935498
16Abnormality of the corticospinal tract (HP:0002492)3.20338572
17Neurofibrillary tangles (HP:0002185)3.16458905
18Dialeptic seizures (HP:0011146)3.13047186
19Truncal ataxia (HP:0002078)3.11931499
20Dysmetria (HP:0001310)3.09537076
21Poor eye contact (HP:0000817)3.08785874
22Generalized tonic-clonic seizures (HP:0002069)3.03902694
23Spastic gait (HP:0002064)3.03874790
24Hemiparesis (HP:0001269)3.03068070
25Dysdiadochokinesis (HP:0002075)3.02662654
26Drooling (HP:0002307)2.97170804
27Excessive salivation (HP:0003781)2.97170804
28Papilledema (HP:0001085)2.96004138
29Depression (HP:0000716)2.90171158
30Scanning speech (HP:0002168)2.84950696
31Agitation (HP:0000713)2.83105060
32Abnormal eating behavior (HP:0100738)2.82356103
33Megalencephaly (HP:0001355)2.81652221
34Intention tremor (HP:0002080)2.80837854
35Urinary bladder sphincter dysfunction (HP:0002839)2.74926457
36Hyperventilation (HP:0002883)2.74889284
37Progressive inability to walk (HP:0002505)2.71741056
38Abnormal social behavior (HP:0012433)2.64404726
39Impaired social interactions (HP:0000735)2.64404726
40Genetic anticipation (HP:0003743)2.63401859
41Urinary urgency (HP:0000012)2.62220229
42Insidious onset (HP:0003587)2.61619727
43Termporal pattern (HP:0011008)2.61619727
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.58062659
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.58062659
46Limb dystonia (HP:0002451)2.54023745
47Impaired vibration sensation in the lower limbs (HP:0002166)2.52131251
48Cerebral inclusion bodies (HP:0100314)2.50509759
49Abnormality of the lower motor neuron (HP:0002366)2.49238253
50Diplopia (HP:0000651)2.47853071
51Abnormality of binocular vision (HP:0011514)2.47853071
52Lower limb muscle weakness (HP:0007340)2.47051777
53Anxiety (HP:0000739)2.45707072
54Hemiplegia (HP:0002301)2.45538497
55Polyphagia (HP:0002591)2.44227145
56Absent speech (HP:0001344)2.43170300
57Postural instability (HP:0002172)2.35151486
58Amblyopia (HP:0000646)2.32311886
59Peripheral hypomyelination (HP:0007182)2.25443267
60Stereotypic behavior (HP:0000733)2.24167627
61Spastic tetraplegia (HP:0002510)2.23594578
62Status epilepticus (HP:0002133)2.22374784
63Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.21085679
64Epileptiform EEG discharges (HP:0011182)2.19512894
65Pheochromocytoma (HP:0002666)2.17319871
66Akinesia (HP:0002304)2.17236668
67EEG with generalized epileptiform discharges (HP:0011198)2.17028212
68Fetal akinesia sequence (HP:0001989)2.16537959
69Pachygyria (HP:0001302)2.16534043
70Blue irides (HP:0000635)2.15526518
71Cortical dysplasia (HP:0002539)2.13213414
72Hypoplasia of the corpus callosum (HP:0002079)2.11065813
73Impaired smooth pursuit (HP:0007772)2.10757519
74Hypsarrhythmia (HP:0002521)2.08504064
75Gait imbalance (HP:0002141)2.04820954
76Aqueductal stenosis (HP:0002410)2.04667680
77Torticollis (HP:0000473)2.03574442
78Abnormality of salivation (HP:0100755)2.03111578
79Clonus (HP:0002169)2.02084800
80Hepatoblastoma (HP:0002884)2.01922059
81Sleep apnea (HP:0010535)2.00312094
82Inability to walk (HP:0002540)1.99891750
83Specific learning disability (HP:0001328)1.99712583
84Nephrogenic diabetes insipidus (HP:0009806)1.97431830
85Aplasia/Hypoplasia of the brainstem (HP:0007362)1.97396342
86Hypoplasia of the brainstem (HP:0002365)1.97396342
87Impaired vibratory sensation (HP:0002495)1.97052884
88Bradykinesia (HP:0002067)1.97041326
89Paraplegia (HP:0010550)1.96294273
90Split foot (HP:0001839)1.96198274
91Papillary thyroid carcinoma (HP:0002895)1.96142344
92Congenital primary aphakia (HP:0007707)1.95878701
93Generalized myoclonic seizures (HP:0002123)1.95324274
94Medial flaring of the eyebrow (HP:0010747)1.94965704
95Abnormality of the labia minora (HP:0012880)1.93527747
96Inappropriate behavior (HP:0000719)1.93348726
97Abnormality of ocular smooth pursuit (HP:0000617)1.90873483
98Esotropia (HP:0000565)1.89626059
99Genital tract atresia (HP:0001827)1.87922965
100Spastic paraplegia (HP:0001258)1.87776505
101Protruding tongue (HP:0010808)1.87373442
102Cerebral hypomyelination (HP:0006808)1.87219170
103Abnormal EKG (HP:0003115)1.86479076
104Amyotrophic lateral sclerosis (HP:0007354)1.85783232
105Exotropia (HP:0000577)1.85532777
106Vaginal atresia (HP:0000148)1.85445030
107Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.85227148
108Gait ataxia (HP:0002066)1.85172080
109Neuroendocrine neoplasm (HP:0100634)1.83974772
110Aplasia involving bones of the upper limbs (HP:0009823)1.81784093
111Aplasia of the phalanges of the hand (HP:0009802)1.81784093
112Aplasia involving bones of the extremities (HP:0009825)1.81784093
113Onion bulb formation (HP:0003383)1.80191454
114Obstructive sleep apnea (HP:0002870)1.80076593
115Failure to thrive in infancy (HP:0001531)1.79719497
116Insomnia (HP:0100785)1.78621146
117Intellectual disability, severe (HP:0010864)1.78509949
118Retinal dysplasia (HP:0007973)1.77857488
119Neuronal loss in central nervous system (HP:0002529)1.77385146
120Lissencephaly (HP:0001339)1.76616624
121Bradycardia (HP:0001662)1.76465138
122Focal dystonia (HP:0004373)1.74191256
123Morphological abnormality of the pyramidal tract (HP:0002062)1.73307033
124Ulnar claw (HP:0001178)1.73181356

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.61844079
2NTRK33.63753090
3MAP3K93.10126181
4EPHA43.00213191
5NTRK22.71920961
6MINK12.64684430
7MAP2K72.54583785
8TNIK2.51536042
9PRPF4B2.44480644
10MAP3K42.40875748
11CASK2.36031773
12PAK62.01656354
13UHMK11.93794397
14MAPK131.79163697
15KSR11.75521719
16PHKG11.69913698
17PHKG21.69913698
18CDK191.67249158
19SGK2231.66634769
20SGK4941.66634769
21NTRK11.62309544
22SIK31.56089043
23BCR1.55194199
24FGFR21.50973558
25DAPK21.50633798
26FRK1.47889147
27CDK51.46045880
28MAP3K121.39777278
29EPHA31.38241234
30OXSR11.37421858
31SGK21.30149323
32MAP2K41.25815622
33TYRO31.23720399
34CAMKK11.23417361
35PNCK1.20154379
36DYRK1A1.19942899
37SIK21.19395332
38KSR21.18863341
39DYRK21.13449004
40PRKD31.13438111
41STK391.10103349
42CSNK1G21.04840345
43CAMKK21.04475646
44STK381.01457913
45PRKCG0.99933388
46WNK30.94754783
47CAMK2A0.93209919
48CDK180.93204580
49SGK30.92192056
50CSNK1G10.91614495
51PINK10.91182234
52GRK50.90683941
53MUSK0.89753987
54TRIM280.88955776
55CCNB10.86771696
56CAMK2B0.86642222
57WNK10.86283519
58CDK140.85038881
59MARK20.84418207
60CDK150.83727019
61PKN10.82056524
62LIMK10.81626139
63STK110.79665900
64FES0.78853727
65RIPK40.78736459
66PLK20.76486392
67DAPK10.73387352
68CDK11A0.71803807
69CAMK10.71730463
70ERBB30.70780824
71SGK10.69397233
72MAP3K60.69035229
73PAK30.68991048
74PRKCE0.68794710
75CSNK1G30.67266527
76CSNK1A1L0.65099556
77RET0.62695239
78BMPR1B0.62393011
79MAP4K20.62053533
80OBSCN0.59900698
81PRKCZ0.59568471
82AKT30.58837997
83PRKCH0.57833357
84LMTK20.57419189
85CAMK2D0.57219928
86CAMK1G0.54718948
87NEK60.53970091
88MAPK120.53207812
89CSNK1D0.53169513
90ARAF0.52652990
91CDK30.50249092
92LATS20.49241231
93MAP3K20.49089175
94IRAK20.47626535
95PRKAA10.45800381
96MAPK100.44916249
97BRD40.44562303
98CAMK40.44331157
99MAPKAPK50.43880838
100ROCK20.43722159
101CAMK2G0.43387469
102FYN0.41993874
103RPS6KA30.41818336
104CSNK1E0.41744103
105CAMK1D0.41447382
106PRKACB0.40213759
107FGR0.39925364
108MKNK20.39225548
109BMPR20.37356897
110PRKACA0.36293557
111DYRK1B0.36248418
112PRKG10.35312962
113MAP3K130.35178780
114ICK0.33507087
115INSRR0.33269436
116PDPK10.33102087
117ALK0.32936964
118* GSK3B0.31702789
119ERBB20.31196473
120RPS6KB10.31074608
121STK38L0.30913309
122HIPK20.30335043
123PRKDC0.29120947
124PRKCB0.29069068
125PDK10.28917558
126CSNK1A10.28637372
127CDC42BPA0.28063266

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.61701167
2Synaptic vesicle cycle_Homo sapiens_hsa047212.98106663
3GABAergic synapse_Homo sapiens_hsa047272.76358198
4Glutamatergic synapse_Homo sapiens_hsa047242.64913762
5Circadian entrainment_Homo sapiens_hsa047132.59407832
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58395435
7Morphine addiction_Homo sapiens_hsa050322.54211152
8Olfactory transduction_Homo sapiens_hsa047402.47829651
9Long-term potentiation_Homo sapiens_hsa047202.21961898
10Dopaminergic synapse_Homo sapiens_hsa047282.15113500
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06916605
12Amphetamine addiction_Homo sapiens_hsa050312.02147133
13Cholinergic synapse_Homo sapiens_hsa047251.95203135
14Salivary secretion_Homo sapiens_hsa049701.92107561
15Taste transduction_Homo sapiens_hsa047421.85740415
16Insulin secretion_Homo sapiens_hsa049111.83566238
17Serotonergic synapse_Homo sapiens_hsa047261.79074274
18Long-term depression_Homo sapiens_hsa047301.69840131
19Cocaine addiction_Homo sapiens_hsa050301.65275568
20Gastric acid secretion_Homo sapiens_hsa049711.62694000
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58212968
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57768279
23Axon guidance_Homo sapiens_hsa043601.56585935
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56457177
25Renin secretion_Homo sapiens_hsa049241.52698409
26Oxytocin signaling pathway_Homo sapiens_hsa049211.46783953
27Calcium signaling pathway_Homo sapiens_hsa040201.38582735
28Phototransduction_Homo sapiens_hsa047441.37658422
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35288916
30Gap junction_Homo sapiens_hsa045401.32423182
31GnRH signaling pathway_Homo sapiens_hsa049121.25680824
32cAMP signaling pathway_Homo sapiens_hsa040241.24697593
33ErbB signaling pathway_Homo sapiens_hsa040121.20841656
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20578151
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16050435
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15536519
37Collecting duct acid secretion_Homo sapiens_hsa049661.11209231
38Type II diabetes mellitus_Homo sapiens_hsa049301.05506891
39Phospholipase D signaling pathway_Homo sapiens_hsa040720.98500783
40Melanogenesis_Homo sapiens_hsa049160.97840013
41Estrogen signaling pathway_Homo sapiens_hsa049150.97687189
42Glioma_Homo sapiens_hsa052140.94412410
43Dorso-ventral axis formation_Homo sapiens_hsa043200.92536564
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90936003
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90006856
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88660768
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87842649
48Butanoate metabolism_Homo sapiens_hsa006500.86423398
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85554518
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85189219
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.83230312
52Choline metabolism in cancer_Homo sapiens_hsa052310.82769158
53Oocyte meiosis_Homo sapiens_hsa041140.81101552
54Vibrio cholerae infection_Homo sapiens_hsa051100.81006678
55Pancreatic secretion_Homo sapiens_hsa049720.78848326
56Cardiac muscle contraction_Homo sapiens_hsa042600.78670140
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78496185
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.78087227
59MAPK signaling pathway_Homo sapiens_hsa040100.78054280
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77044753
61Renal cell carcinoma_Homo sapiens_hsa052110.76055694
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.73594628
63Ras signaling pathway_Homo sapiens_hsa040140.73491924
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70289730
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69490995
66Alcoholism_Homo sapiens_hsa050340.69266528
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68803731
68Dilated cardiomyopathy_Homo sapiens_hsa054140.67835734
69Inositol phosphate metabolism_Homo sapiens_hsa005620.67787428
70Endocytosis_Homo sapiens_hsa041440.67205985
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64759824
72Endometrial cancer_Homo sapiens_hsa052130.64562776
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64523944
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63035545
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61429513
76Wnt signaling pathway_Homo sapiens_hsa043100.60546047
77Hippo signaling pathway_Homo sapiens_hsa043900.60102689
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59863619
79Circadian rhythm_Homo sapiens_hsa047100.59716356
80Ether lipid metabolism_Homo sapiens_hsa005650.57655034
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56699205
82Bile secretion_Homo sapiens_hsa049760.56476618
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56359745
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56237931
85Fatty acid biosynthesis_Homo sapiens_hsa000610.54951128
86Thyroid hormone synthesis_Homo sapiens_hsa049180.54187209
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52953176
88VEGF signaling pathway_Homo sapiens_hsa043700.52243064
89Nitrogen metabolism_Homo sapiens_hsa009100.50984879
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50865917
91Rap1 signaling pathway_Homo sapiens_hsa040150.50834766
92Chemokine signaling pathway_Homo sapiens_hsa040620.49811839
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49589148
94Colorectal cancer_Homo sapiens_hsa052100.45866329
95Prion diseases_Homo sapiens_hsa050200.45118081
96AMPK signaling pathway_Homo sapiens_hsa041520.44355841
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44139494
98Ovarian steroidogenesis_Homo sapiens_hsa049130.43077762
99Type I diabetes mellitus_Homo sapiens_hsa049400.42487830
100Regulation of autophagy_Homo sapiens_hsa041400.42272533
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41181389
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.41034418
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39321418
104mTOR signaling pathway_Homo sapiens_hsa041500.37243339
105Prolactin signaling pathway_Homo sapiens_hsa049170.36600821
106Insulin signaling pathway_Homo sapiens_hsa049100.36573133
107Hedgehog signaling pathway_Homo sapiens_hsa043400.36355548
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35767062
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35345595
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35099588
111ABC transporters_Homo sapiens_hsa020100.32437711
112Glucagon signaling pathway_Homo sapiens_hsa049220.32299788
113Tight junction_Homo sapiens_hsa045300.32228890
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30505795

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