CLC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mast cell activation involved in immune response (GO:0033008)9.86670112
2positive regulation of mast cell degranulation (GO:0043306)9.86670112
3positive regulation of mast cell activation (GO:0033005)8.69800184
4regulation of mast cell activation involved in immune response (GO:0033006)7.59197699
5positive regulation of myeloid leukocyte mediated immunity (GO:0002888)7.57701803
6positive regulation of leukocyte degranulation (GO:0043302)7.52886752
7regulation of mast cell degranulation (GO:0043304)6.80624951
8regulation of mast cell activation (GO:0033003)6.37351021
9angiotensin maturation (GO:0002003)6.29452094
10positive regulation of regulated secretory pathway (GO:1903307)6.17227643
11cellular biogenic amine biosynthetic process (GO:0042401)6.03846483
12amine biosynthetic process (GO:0009309)5.71712265
13regulation of myeloid leukocyte mediated immunity (GO:0002886)5.57530357
14regulation of leukocyte degranulation (GO:0043300)5.55219133
15catechol-containing compound biosynthetic process (GO:0009713)5.31299242
16catecholamine biosynthetic process (GO:0042423)5.31299242
17regulation of regulated secretory pathway (GO:1903305)4.78844335
18neutrophil activation (GO:0042119)4.45619035
19lipoxygenase pathway (GO:0019372)4.36993649
20positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.34201554
21superoxide anion generation (GO:0042554)4.25886727
22negative regulation of interleukin-10 production (GO:0032693)4.23165726
23positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.22732853
24positive regulation of interleukin-4 production (GO:0032753)4.09247196
25granulocyte activation (GO:0036230)3.97225016
26neutrophil activation involved in immune response (GO:0002283)3.95576917
27innate immune response in mucosa (GO:0002227)3.92860169
28positive regulation of gamma-delta T cell activation (GO:0046645)3.84196665
29cytokine secretion (GO:0050663)3.75285149
30detection of other organism (GO:0098543)3.74533157
31regulation of B cell receptor signaling pathway (GO:0050855)3.71319633
32negative regulation of mast cell activation (GO:0033004)3.71207955
33cytokine biosynthetic process (GO:0042089)3.68744790
34leukotriene biosynthetic process (GO:0019370)3.68573402
35cellular extravasation (GO:0045123)3.64157898
36respiratory burst (GO:0045730)3.54496789
37mRNA transcription from RNA polymerase II promoter (GO:0042789)3.50052141
38regulation of interleukin-4 production (GO:0032673)3.48773422
39detection of bacterium (GO:0016045)3.46805429
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.46469781
41positive regulation of granulocyte differentiation (GO:0030854)3.43069747
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.42190079
43mucosal immune response (GO:0002385)3.40328530
44production of molecular mediator involved in inflammatory response (GO:0002532)3.40224635
45negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.37787220
46negative regulation of T-helper cell differentiation (GO:0045623)3.37787220
47endosome to pigment granule transport (GO:0043485)3.36638352
48endosome to melanosome transport (GO:0035646)3.36638352
49response to peptidoglycan (GO:0032494)3.32467978
50organ or tissue specific immune response (GO:0002251)3.32182992
51regulation of interleukin-5 production (GO:0032674)3.31308932
52positive regulation of natural killer cell differentiation (GO:0032825)3.26695315
53replication fork processing (GO:0031297)3.26692554
54interleukin-6-mediated signaling pathway (GO:0070102)3.24884675
55negative regulation of cell killing (GO:0031342)3.22237099
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.22237099
57regulation of interferon-beta biosynthetic process (GO:0045357)3.21188486
58cytokine metabolic process (GO:0042107)3.16388484
59regulation of isotype switching to IgG isotypes (GO:0048302)3.14731623
60T cell migration (GO:0072678)3.14267074
61leukotriene metabolic process (GO:0006691)3.12463647
62negative regulation of lymphocyte mediated immunity (GO:0002707)3.12437676
63defense response to fungus (GO:0050832)3.11641632
64negative regulation of bone mineralization (GO:0030502)3.08199251
65negative regulation of adaptive immune response (GO:0002820)3.06097396
66positive regulation of interferon-alpha production (GO:0032727)3.05375018
67mRNA transcription (GO:0009299)3.05131819
68positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.00867521
69detection of external biotic stimulus (GO:0098581)2.98272365
70positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.97966075
71peroxisome fission (GO:0016559)2.94207441
72cellular response to virus (GO:0098586)2.93850517
73regulation of natural killer cell differentiation (GO:0032823)2.93209714
74centrosome duplication (GO:0051298)2.91403638
75programmed necrotic cell death (GO:0097300)2.89861280
76positive regulation of DNA recombination (GO:0045911)2.88936833
77negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.88279586
78regulation of interleukin-8 biosynthetic process (GO:0045414)2.87569412
79positive regulation of B cell differentiation (GO:0045579)2.87537874
80positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.86584238
81regulation of interleukin-10 production (GO:0032653)2.85432008
82neutrophil mediated immunity (GO:0002446)2.83729029
83immunoglobulin mediated immune response (GO:0016064)2.82141522
84leukocyte migration involved in inflammatory response (GO:0002523)2.81873845
85sequestering of actin monomers (GO:0042989)2.81847361
86regulation of interferon-alpha production (GO:0032647)2.80747799
87regulation of MHC class II biosynthetic process (GO:0045346)2.80631709
88leukocyte aggregation (GO:0070486)2.80152918
89defense response to protozoan (GO:0042832)2.78407679
90regulation of gamma-delta T cell activation (GO:0046643)2.78250297
91CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.73798446
92phenol-containing compound biosynthetic process (GO:0046189)2.73402566
93reactive oxygen species biosynthetic process (GO:1903409)2.72984229
94regulation of gamma-delta T cell differentiation (GO:0045586)2.72748749
95response to protozoan (GO:0001562)2.72389783
96negative regulation of T cell mediated immunity (GO:0002710)2.72143991
97regulation of double-strand break repair via homologous recombination (GO:0010569)2.72083754
98modulation by symbiont of host immune response (GO:0052553)2.69826259
99modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.69826259
100imidazole-containing compound metabolic process (GO:0052803)13.1809655

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.03095883
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.49093140
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.27985405
4MYB_21317192_ChIP-Seq_ERMYB_Mouse3.71006767
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.37563534
6E2F7_22180533_ChIP-Seq_HELA_Human2.91125773
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.90319467
8* SPI1_23547873_ChIP-Seq_NB4_Human2.67041497
9VDR_21846776_ChIP-Seq_THP-1_Human2.65086479
10SCL_19346495_ChIP-Seq_HPC-7_Human2.64539404
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.60697143
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58841270
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.49374017
14VDR_24763502_ChIP-Seq_THP-1_Human2.42254944
15RUNX_20019798_ChIP-Seq_JUKART_Human2.32961876
16MYB_26560356_Chip-Seq_TH2_Human2.25534966
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.18662006
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17608658
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16113286
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09081663
21RUNX1_22412390_ChIP-Seq_EML_Mouse2.00279540
22SPI1_23127762_ChIP-Seq_K562_Human2.00232264
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.2158504
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95847691
25UTX_26944678_Chip-Seq_JUKART_Human1.94712885
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91891638
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90153891
28LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.87084022
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.85058497
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81530894
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75938185
32VDR_24787735_ChIP-Seq_THP-1_Human1.72577771
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.68076892
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67512349
35GATA1_19941826_ChIP-Seq_K562_Human1.65812886
36GATA2_22383799_ChIP-Seq_G1ME_Mouse1.59965636
37GATA1_22025678_ChIP-Seq_K562_Human1.59399087
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58686010
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57683571
40GATA1_22383799_ChIP-Seq_G1ME_Mouse1.56395309
41MAF_26560356_Chip-Seq_TH1_Human1.56247669
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56184809
43MYC_22102868_ChIP-Seq_BL_Human1.53710924
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.52864707
45MYB_26560356_Chip-Seq_TH1_Human1.52780488
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52404464
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.51333434
48TCF7_22412390_ChIP-Seq_EML_Mouse1.49229671
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48264589
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42412487
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41115028
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40112116
53GATA3_27048872_Chip-Seq_THYMUS_Human1.39837989
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39576242
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38459073
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35121755
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.33761713
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32913926
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32049189
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31511142
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30209094
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30158496
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30089693
64GATA2_19941826_ChIP-Seq_K562_Human1.30059893
65MAF_26560356_Chip-Seq_TH2_Human1.30001139
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29459992
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24574407
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24454536
69GATA3_26560356_Chip-Seq_TH2_Human1.20597785
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13251901
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08619209
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99593606
73KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97737938
74IRF1_19129219_ChIP-ChIP_H3396_Human0.95196396
75PU_27001747_Chip-Seq_BMDM_Mouse0.95133524
76NCOR1_26117541_ChIP-Seq_K562_Human0.94621561
77KDM2B_26808549_Chip-Seq_DND41_Human0.91671930
78ELF1_20517297_ChIP-Seq_JURKAT_Human0.91332679
79SPI1_20517297_ChIP-Seq_HL60_Human0.90767005
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90680123
81* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90347250
82KDM2B_26808549_Chip-Seq_JURKAT_Human0.88878037
83CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88787235
84ETS1_22383799_ChIP-Seq_G1ME_Mouse0.87644020
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87606981
86HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86355044
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85029901
88RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84143462
89BCL6_27268052_Chip-Seq_Bcells_Human0.83750429
90PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83345205
91BCOR_27268052_Chip-Seq_Bcells_Human0.82110381
92SMRT_27268052_Chip-Seq_Bcells_Human0.81632511
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80613879
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79818913
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.77991464
96RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76921431
97LXR_22292898_ChIP-Seq_THP-1_Human0.76229458
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76056138
99P300_27268052_Chip-Seq_Bcells_Human0.73275994
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72652766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception3.94440770
2MP0006082_CNS_inflammation3.31040132
3MP0003436_decreased_susceptibility_to3.25838277
4MP0003303_peritoneal_inflammation3.22570862
5MP0002148_abnormal_hypersensitivity_rea3.07279528
6MP0001835_abnormal_antigen_presentation2.87565666
7MP0002419_abnormal_innate_immunity2.75345391
8MP0001790_abnormal_immune_system2.71090647
9MP0005387_immune_system_phenotype2.71090647
10MP0003724_increased_susceptibility_to2.68692097
11MP0005075_abnormal_melanosome_morpholog2.55628899
12MP0001873_stomach_inflammation2.52334953
13MP0002405_respiratory_system_inflammati2.52255766
14MP0005464_abnormal_platelet_physiology2.48287040
15MP0005025_abnormal_response_to2.38540025
16MP0001800_abnormal_humoral_immune2.35697262
17MP0009115_abnormal_fat_cell2.32257739
18MP0003183_abnormal_peptide_metabolism2.30769697
19MP0002420_abnormal_adaptive_immunity2.26281067
20MP0001819_abnormal_immune_cell2.25281713
21MP0005058_abnormal_lysosome_morphology2.24473941
22MP0002971_abnormal_brown_adipose2.23565916
23MP0000465_gastrointestinal_hemorrhage2.14083361
24MP0002452_abnormal_antigen_presenting2.11591247
25MP0005171_absent_coat_pigmentation2.10472560
26MP0002723_abnormal_immune_serum2.06734256
27MP0005000_abnormal_immune_tolerance2.02660460
28MP0002398_abnormal_bone_marrow1.99584503
29MP0000716_abnormal_immune_system1.93753060
30MP0005076_abnormal_cell_differentiation1.93320252
31MP0005671_abnormal_response_to1.88842523
32MP0009840_abnormal_foam_cell1.88710052
33MP0008961_abnormal_basal_metabolism1.81706962
34MP0009785_altered_susceptibility_to1.80470574
35MP0002722_abnormal_immune_system1.79061558
36MP0000685_abnormal_immune_system1.78600511
37MP0003763_abnormal_thymus_physiology1.74054954
38MP0005310_abnormal_salivary_gland1.71272075
39MP0002429_abnormal_blood_cell1.69695526
40MP0009765_abnormal_xenobiotic_induced1.62791523
41MP0005083_abnormal_biliary_tract1.55545033
42MP0003172_abnormal_lysosome_physiology1.53993158
43MP0000689_abnormal_spleen_morphology1.53200982
44MP0000703_abnormal_thymus_morphology1.51541652
45MP0009278_abnormal_bone_marrow1.49510022
46MP0003191_abnormal_cellular_cholesterol1.46152104
47MP0001845_abnormal_inflammatory_respons1.43617661
48MP0004947_skin_inflammation1.39664684
49MP0005448_abnormal_energy_balance1.39150904
50MP0001533_abnormal_skeleton_physiology1.38575479
51MP0001853_heart_inflammation1.37762018
52MP0002396_abnormal_hematopoietic_system1.36975390
53MP0002877_abnormal_melanocyte_morpholog1.33110766
54MP0002970_abnormal_white_adipose1.32799785
55MP0003638_abnormal_response/metabolism_1.31469022
56MP0003300_gastrointestinal_ulcer1.30438780
57MP0002733_abnormal_thermal_nociception1.28043829
58MP0001348_abnormal_lacrimal_gland1.26545358
59MP0005334_abnormal_fat_pad1.26450024
60MP0000371_diluted_coat_color1.21058309
61MP0008469_abnormal_protein_level1.20249838
62MP0003656_abnormal_erythrocyte_physiolo1.18553331
63MP0000372_irregular_coat_pigmentation1.17246355
64MP0001545_abnormal_hematopoietic_system1.15004229
65MP0005397_hematopoietic_system_phenotyp1.15004229
66MP0005503_abnormal_tendon_morphology1.13827550
67MP0005174_abnormal_tail_pigmentation1.07530496
68MP0004185_abnormal_adipocyte_glucose1.07197534
69MP0009763_increased_sensitivity_to1.03859872
70MP0003828_pulmonary_edema1.03193341
71MP0008057_abnormal_DNA_replication1.01794373
72MP0003690_abnormal_glial_cell1.01193317
73MP0008260_abnormal_autophagy0.99966486
74MP0008058_abnormal_DNA_repair0.97701207
75MP0004883_abnormal_blood_vessel0.96956393
76MP0005451_abnormal_body_composition0.92469547
77MP0004808_abnormal_hematopoietic_stem0.91896891
78MP0004381_abnormal_hair_follicle0.90888316
79MP0001663_abnormal_digestive_system0.88399829
80MP0002734_abnormal_mechanical_nocicepti0.86060278
81MP0002998_abnormal_bone_remodeling0.86048893
82MP0003806_abnormal_nucleotide_metabolis0.85391613
83MP0009764_decreased_sensitivity_to0.85081981
84MP0000858_altered_metastatic_potential0.83973433
85MP0002132_abnormal_respiratory_system0.83685300
86MP0010155_abnormal_intestine_physiology0.81630409
87MP0003787_abnormal_imprinting0.79704687
88MP0000733_abnormal_muscle_development0.79378185
89MP0008995_early_reproductive_senescence0.78662978
90MP0009333_abnormal_splenocyte_physiolog0.76127082
91MP0003283_abnormal_digestive_organ0.76085082
92MP0001851_eye_inflammation0.75138492
93MP0005166_decreased_susceptibility_to0.73362163
94MP0000015_abnormal_ear_pigmentation0.71545321
95MP0000569_abnormal_digit_pigmentation0.70892472
96MP0005319_abnormal_enzyme/_coenzyme0.70102436
97MP0005390_skeleton_phenotype0.67966100
98MP0010094_abnormal_chromosome_stability0.66728987
99MP0003279_aneurysm0.66574008
100MP0005584_abnormal_enzyme/coenzyme_acti0.65464240

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.43073324
2Male infertility (HP:0003251)5.40565570
3Recurrent abscess formation (HP:0002722)5.31230924
4Recurrent bacterial skin infections (HP:0005406)5.14674951
5Abnormality of macrophages (HP:0004311)5.05657696
6Abnormal delayed hypersensitivity skin test (HP:0002963)5.00299876
7Recurrent gram-negative bacterial infections (HP:0005420)4.68255616
8Failure to thrive in infancy (HP:0001531)4.64973383
9Autoimmune thrombocytopenia (HP:0001973)4.44407843
10Recurrent cutaneous fungal infections (HP:0011370)4.27217294
11Chronic mucocutaneous candidiasis (HP:0002728)4.27217294
12Recurrent fungal infections (HP:0002841)4.07220726
13Recurrent skin infections (HP:0001581)3.98818884
14Stomatitis (HP:0010280)3.97626140
15Recurrent viral infections (HP:0004429)3.94121050
16Obstructive lung disease (HP:0006536)3.69762821
17Chronic obstructive pulmonary disease (HP:0006510)3.69762821
18Abnormality of T cell physiology (HP:0011840)3.68522120
19Hypochromic microcytic anemia (HP:0004840)3.67105293
20Gastrointestinal infarctions (HP:0005244)3.61743729
21Episodic fever (HP:0001954)3.55704672
22Mediastinal lymphadenopathy (HP:0100721)3.55561105
23Papilledema (HP:0001085)3.33491626
24Myositis (HP:0100614)3.29130590
25Meningitis (HP:0001287)3.26013357
26Recurrent sinusitis (HP:0011108)3.25987069
27Premature graying of hair (HP:0002216)3.19443756
28Orthostatic hypotension (HP:0001278)3.16233842
29Retrobulbar optic neuritis (HP:0100654)3.06725164
30Optic neuritis (HP:0100653)3.06725164
31Increased cerebral lipofuscin (HP:0011813)3.06274143
32Gingivitis (HP:0000230)3.04735414
33Orchitis (HP:0100796)3.02557219
34Pustule (HP:0200039)3.01385316
35Prolonged bleeding time (HP:0003010)2.98414788
36Cellulitis (HP:0100658)2.98289406
37Alveolar cell carcinoma (HP:0006519)2.96928204
38Elevated erythrocyte sedimentation rate (HP:0003565)2.96539758
39Abnormality of T cells (HP:0002843)2.93038047
40Osteomyelitis (HP:0002754)2.92112731
41Increased neuronal autofluorescent lipopigment (HP:0002074)2.91060850
42Neoplasm of the tracheobronchial system (HP:0100552)2.87254672
43Vacuolated lymphocytes (HP:0001922)2.85021606
44Panhypogammaglobulinemia (HP:0003139)2.84079443
45Encephalitis (HP:0002383)2.73526457
46Spontaneous hematomas (HP:0007420)2.71227714
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.61389294
48Colitis (HP:0002583)2.59876351
49Abnormality of the heme biosynthetic pathway (HP:0010472)2.58939482
50Autoimmune hemolytic anemia (HP:0001890)2.58666350
51Vasculitis (HP:0002633)2.57234208
52Urticaria (HP:0001025)2.54411378
53Hypochromic anemia (HP:0001931)2.53964921
54T lymphocytopenia (HP:0005403)2.51569125
55Chest pain (HP:0100749)2.47406319
56Acute hepatic failure (HP:0006554)2.46073494
57Rough bone trabeculation (HP:0100670)2.44293443
58Abnormality of T cell number (HP:0011839)2.42351078
59Inflammation of the large intestine (HP:0002037)2.35812470
60Petechiae (HP:0000967)2.32990887
61Bone marrow hypocellularity (HP:0005528)2.32663987
62Gingival bleeding (HP:0000225)2.31414217
63Keratoconjunctivitis sicca (HP:0001097)2.30629460
64Agammaglobulinemia (HP:0004432)2.27058184
65Aseptic necrosis (HP:0010885)2.26090231
66Epistaxis (HP:0000421)2.25774674
67Dysostosis multiplex (HP:0000943)2.21372969
68Microcytic anemia (HP:0001935)2.20491125
69Gastrointestinal inflammation (HP:0004386)2.19179067
70Abnormality of transition element cation homeostasis (HP:0011030)2.18537487
71Glomerulopathy (HP:0100820)2.18392384
72Pulmonary infiltrates (HP:0002113)2.17223950
73Abnormality of pyrimidine metabolism (HP:0004353)2.15200965
74Upper motor neuron abnormality (HP:0002127)2.13455347
75Hemoptysis (HP:0002105)2.10257291
76Global brain atrophy (HP:0002283)2.10001330
77Arterial thrombosis (HP:0004420)2.09953428
78Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08827663
79Keratoconjunctivitis (HP:0001096)2.07938398
80Recurrent lower respiratory tract infections (HP:0002783)2.06493572
81Cellular immunodeficiency (HP:0005374)2.04470691
82Abnormality of the pleura (HP:0002103)2.04265610
83Ventricular fibrillation (HP:0001663)2.03729285
84Neurodegeneration (HP:0002180)2.03031222
85Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.02799804
86Leukocytosis (HP:0001974)2.02448144
87Albinism (HP:0001022)1.98701534
88Increased serum ferritin (HP:0003281)1.96683268
89Impaired proprioception (HP:0010831)1.96514885
90Hypermelanotic macule (HP:0001034)1.95299719
91Abnormality of iron homeostasis (HP:0011031)1.94753222
92Generalized hyperpigmentation (HP:0007440)1.92466099
93Skin ulcer (HP:0200042)1.91947673
94Granulocytopenia (HP:0001913)1.89978837
95Spastic diplegia (HP:0001264)1.86892682
96IgG deficiency (HP:0004315)1.85219676
97Hepatitis (HP:0012115)1.82457605
98Basal ganglia calcification (HP:0002135)1.78630141
99Splenomegaly (HP:0001744)1.78457402
100Viral hepatitis (HP:0006562)1.78331400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM288.53219558
2GRK63.30447960
3TAOK13.03052986
4RIPK43.00904524
5PRPF4B2.98055720
6BLK2.74157883
7MAP4K12.49704774
8IRAK42.46694282
9FES2.46201449
10TYK22.23558285
11MARK31.81627538
12TNIK1.77325823
13MAP2K31.75134023
14CSK1.65580817
15BTK1.63990430
16MATK1.60944128
17TNK21.57706595
18PRKD21.53336235
19LYN1.51312437
20FER1.51306595
21ZAP701.50650291
22SYK1.50602869
23IRAK31.39551734
24CSF1R1.36554534
25IKBKE1.35527855
26JAK21.33449676
27TAOK21.32555887
28TRIB31.27742363
29BMPR21.26475977
30GRK71.25239139
31PDK21.18782891
32ERN11.15617839
33TBK11.10940824
34TGFBR21.09837709
35MARK21.09127200
36CAMK1G1.06573743
37HCK1.06567623
38TEC1.05955057
39CDK60.98032339
40FGR0.96627518
41ITK0.94444092
42HIPK20.93000896
43DAPK20.91334619
44LCK0.90880377
45CAMK1D0.90826855
46PIM10.89759946
47SIK30.88857840
48KIT0.87634158
49YES10.85183755
50PDK10.84936058
51MAP3K20.82553968
52TRPM70.80103270
53JAK10.79076696
54STK100.77522195
55TXK0.73692618
56SIK20.72502874
57PIK3CG0.70133486
58MAP3K30.69917997
59JAK30.68083684
60CAMKK20.65480311
61MAP3K110.63815739
62FRK0.63046225
63MAP3K10.62499307
64MAP3K140.60469970
65WNK10.60253457
66DYRK1B0.60027062
67PDPK10.56433882
68CAMKK10.55969215
69BCKDK0.54879181
70PKN20.54618752
71MOS0.54164255
72IKBKB0.50277130
73STK380.49477995
74TAOK30.47284263
75RPS6KC10.41165368
76RPS6KL10.41165368
77RPS6KA60.40477733
78PTK60.39281253
79PRKCH0.38531676
80PRKCQ0.36742495
81MAP2K20.36645716
82INSR0.36002442
83GSK3A0.35461398
84IRAK20.35265797
85MAPK40.34721209
86MAPKAPK20.34176000
87CHUK0.32849139
88FYN0.29122268
89MAP3K60.27441623
90ACVR1B0.27073007
91PRKCD0.26700717
92CAMK40.26484858
93MAPK30.25044865
94MAPK100.24357114
95STK110.24021899
96PRKCZ0.22453616
97ATR0.21671431
98ABL10.20903730
99EPHB10.20417705
100AKT10.20055072

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053106.28999377
2Histidine metabolism_Homo sapiens_hsa003404.46678983
3Renin-angiotensin system_Homo sapiens_hsa046144.08485404
4Other glycan degradation_Homo sapiens_hsa005113.86440138
5Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.74185097
6Leishmaniasis_Homo sapiens_hsa051402.50847056
7Hematopoietic cell lineage_Homo sapiens_hsa046402.30289558
8Osteoclast differentiation_Homo sapiens_hsa043802.04638778
9Staphylococcus aureus infection_Homo sapiens_hsa051501.72563698
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.71180139
11B cell receptor signaling pathway_Homo sapiens_hsa046621.69771385
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65854199
13Jak-STAT signaling pathway_Homo sapiens_hsa046301.49783190
14Allograft rejection_Homo sapiens_hsa053301.49085206
15Sphingolipid signaling pathway_Homo sapiens_hsa040711.44659253
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41944431
17Autoimmune thyroid disease_Homo sapiens_hsa053201.39886047
18Malaria_Homo sapiens_hsa051441.34885175
19Lysosome_Homo sapiens_hsa041421.32343519
20Primary immunodeficiency_Homo sapiens_hsa053401.32310452
21Tuberculosis_Homo sapiens_hsa051521.32240604
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.31788364
23Glycerophospholipid metabolism_Homo sapiens_hsa005641.31785326
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29111536
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28967565
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24613803
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.22693028
28Platelet activation_Homo sapiens_hsa046111.20247634
29Chemokine signaling pathway_Homo sapiens_hsa040621.14168568
30Measles_Homo sapiens_hsa051621.12071036
31Hepatitis C_Homo sapiens_hsa051601.11924165
32Legionellosis_Homo sapiens_hsa051341.10051538
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09150644
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06223100
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05739064
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02197116
37Acute myeloid leukemia_Homo sapiens_hsa052211.01674779
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01218193
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.00206065
40African trypanosomiasis_Homo sapiens_hsa051430.99512163
41T cell receptor signaling pathway_Homo sapiens_hsa046600.98757456
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98646393
43Hepatitis B_Homo sapiens_hsa051610.96784979
44Non-small cell lung cancer_Homo sapiens_hsa052230.96317002
45Graft-versus-host disease_Homo sapiens_hsa053320.92370248
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.91350805
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87444790
48Antigen processing and presentation_Homo sapiens_hsa046120.83861004
49Pancreatic secretion_Homo sapiens_hsa049720.82043525
50Starch and sucrose metabolism_Homo sapiens_hsa005000.81052901
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80895546
52Herpes simplex infection_Homo sapiens_hsa051680.78216149
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77982478
54Toxoplasmosis_Homo sapiens_hsa051450.76265584
55Phagosome_Homo sapiens_hsa041450.74585552
56Influenza A_Homo sapiens_hsa051640.73432078
57Chronic myeloid leukemia_Homo sapiens_hsa052200.72820986
58TNF signaling pathway_Homo sapiens_hsa046680.72207102
59Pertussis_Homo sapiens_hsa051330.69217105
60Arachidonic acid metabolism_Homo sapiens_hsa005900.66322539
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66080501
62Caffeine metabolism_Homo sapiens_hsa002320.64190143
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63958910
64Renal cell carcinoma_Homo sapiens_hsa052110.63915503
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61898820
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.60914710
67Pancreatic cancer_Homo sapiens_hsa052120.55953261
68Apoptosis_Homo sapiens_hsa042100.54069292
69HIF-1 signaling pathway_Homo sapiens_hsa040660.52748587
70Insulin resistance_Homo sapiens_hsa049310.51006705
71Galactose metabolism_Homo sapiens_hsa000520.48868227
72Systemic lupus erythematosus_Homo sapiens_hsa053220.48678691
73Viral myocarditis_Homo sapiens_hsa054160.44341791
74Type I diabetes mellitus_Homo sapiens_hsa049400.43301320
75Fanconi anemia pathway_Homo sapiens_hsa034600.41387823
76Choline metabolism in cancer_Homo sapiens_hsa052310.41361314
77Rheumatoid arthritis_Homo sapiens_hsa053230.39472956
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38888957
79Viral carcinogenesis_Homo sapiens_hsa052030.38536335
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.36634798
81GnRH signaling pathway_Homo sapiens_hsa049120.36614657
82Olfactory transduction_Homo sapiens_hsa047400.31889750
83Protein digestion and absorption_Homo sapiens_hsa049740.28749115
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28707146
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27797457
86Inositol phosphate metabolism_Homo sapiens_hsa005620.27157878
87Ether lipid metabolism_Homo sapiens_hsa005650.26955667
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26900460
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26427611
90Nitrogen metabolism_Homo sapiens_hsa009100.26376012
91Homologous recombination_Homo sapiens_hsa034400.26271142
92Salmonella infection_Homo sapiens_hsa051320.24559075
93Endocytosis_Homo sapiens_hsa041440.23288101
94Peroxisome_Homo sapiens_hsa041460.18944474
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.18399175
96HTLV-I infection_Homo sapiens_hsa051660.16718856
97Regulation of autophagy_Homo sapiens_hsa041400.15202188
98Long-term depression_Homo sapiens_hsa047300.13906430
99Glioma_Homo sapiens_hsa052140.13821601
100Prolactin signaling pathway_Homo sapiens_hsa049170.13754727

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