CLCA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1UDP-N-acetylglucosamine metabolic process (GO:0006047)9.43238655
2maintenance of gastrointestinal epithelium (GO:0030277)9.37603085
3intestinal epithelial cell development (GO:0060576)8.10890698
4intestinal absorption (GO:0050892)7.50741496
5regulation of guanylate cyclase activity (GO:0031282)7.40420094
6epithelial structure maintenance (GO:0010669)7.27246765
7O-glycan processing (GO:0016266)6.83438389
8NADH metabolic process (GO:0006734)6.59761331
9sulfation (GO:0051923)6.45808490
10lung secretory cell differentiation (GO:0061140)6.27585442
11bundle of His cell to Purkinje myocyte communication (GO:0086069)6.27559238
12lipoprotein transport (GO:0042953)5.96010322
13regulation of cellular extravasation (GO:0002691)5.71831469
14epoxygenase P450 pathway (GO:0019373)5.71470457
15actin filament depolymerization (GO:0030042)5.61872738
16positive regulation of guanylate cyclase activity (GO:0031284)5.59623076
17fat-soluble vitamin biosynthetic process (GO:0042362)5.54498132
18sulfate transmembrane transport (GO:1902358)5.46064523
19regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.36887342
20endocrine process (GO:0050886)5.36887342
21regulation of systemic arterial blood pressure by hormone (GO:0001990)5.36887342
22intestinal cholesterol absorption (GO:0030299)5.23371018
23digestive system process (GO:0022600)5.20684256
24bile acid and bile salt transport (GO:0015721)4.94509551
25cellular glucuronidation (GO:0052695)4.91977328
26antibacterial humoral response (GO:0019731)4.91209558
27hormone catabolic process (GO:0042447)4.87637327
28regulation of systemic arterial blood pressure (GO:0003073)4.84522640
29uronic acid metabolic process (GO:0006063)4.82461601
30glucuronate metabolic process (GO:0019585)4.82461601
31fructose metabolic process (GO:0006000)4.79903615
32glandular epithelial cell differentiation (GO:0002067)4.74986475
33antimicrobial humoral response (GO:0019730)4.73720198
34receptor guanylyl cyclase signaling pathway (GO:0007168)4.66889904
353-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.64959966
36purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.64959966
37positive regulation of respiratory burst (GO:0060267)4.64385318
38angiotensin maturation (GO:0002003)4.50419310
39positive regulation of pseudopodium assembly (GO:0031274)4.50065252
40regulation of cGMP biosynthetic process (GO:0030826)4.49404715
41regulation of vitamin metabolic process (GO:0030656)4.48478648
42renal system process involved in regulation of blood volume (GO:0001977)4.43543360
43vitamin A metabolic process (GO:0006776)4.40927942
44diacylglycerol metabolic process (GO:0046339)4.39710956
45protein O-linked glycosylation (GO:0006493)4.36882850
46sulfate transport (GO:0008272)4.35610970
47urea cycle (GO:0000050)4.33321843
48sperm capacitation (GO:0048240)4.27802391
49nucleotide-sugar biosynthetic process (GO:0009226)4.24870750
50bicarbonate transport (GO:0015701)4.24868574
51drug metabolic process (GO:0017144)4.23497826
52nucleotide-sugar metabolic process (GO:0009225)4.20930801
53flavonoid metabolic process (GO:0009812)4.12336593
54regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.10235368
55urea metabolic process (GO:0019627)4.09679346
56peptide hormone processing (GO:0016486)4.07640185
57sulfur amino acid catabolic process (GO:0000098)4.04192419
58regulation of pseudopodium assembly (GO:0031272)4.03687432
59peptide catabolic process (GO:0043171)3.99628439
60glycosphingolipid catabolic process (GO:0046479)3.97139444
61glycolipid catabolic process (GO:0019377)3.94714469
62hepatocyte apoptotic process (GO:0097284)3.87792649
63very-low-density lipoprotein particle assembly (GO:0034379)3.85918168
64antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.84438228
65glomerular filtration (GO:0003094)3.83232297
66regulation of cholesterol homeostasis (GO:2000188)3.81046883
67positive regulation of glycoprotein biosynthetic process (GO:0010560)3.80590109
68digestion (GO:0007586)3.79780741
69nitrogen cycle metabolic process (GO:0071941)3.77884423
70regulation of cGMP metabolic process (GO:0030823)3.72046424
71sulfur compound transport (GO:0072348)3.71827364
72adhesion of symbiont to host cell (GO:0044650)3.70136391
73virion attachment to host cell (GO:0019062)3.70136391
74antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.69719083
75galactose catabolic process (GO:0019388)3.69392292
76amino sugar metabolic process (GO:0006040)3.65772106
77transcytosis (GO:0045056)3.65378075
78regulation of bile acid biosynthetic process (GO:0070857)3.64679948
79regulation of triglyceride catabolic process (GO:0010896)3.55996100
80antigen processing and presentation of endogenous antigen (GO:0019883)3.51867166
81renal filtration (GO:0097205)3.49010955
82positive regulation of glycoprotein metabolic process (GO:1903020)3.47290377
83drug catabolic process (GO:0042737)3.46999683
84vitamin transmembrane transport (GO:0035461)3.45764073
85fucose catabolic process (GO:0019317)3.40841893
86L-fucose metabolic process (GO:0042354)3.40841893
87L-fucose catabolic process (GO:0042355)3.40841893
88pyrimidine-containing compound transmembrane transport (GO:0072531)3.40423624
89thyroid hormone metabolic process (GO:0042403)3.36691746
90arginine metabolic process (GO:0006525)3.36307371
91nucleoside diphosphate biosynthetic process (GO:0009133)3.35118356
92plasma lipoprotein particle assembly (GO:0034377)3.34793965
93calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.33700699
94sialylation (GO:0097503)3.33141737
95ventricular cardiac muscle cell action potential (GO:0086005)3.29444099
96oligosaccharide biosynthetic process (GO:0009312)3.28905645
97hemidesmosome assembly (GO:0031581)3.28712213
98cGMP-mediated signaling (GO:0019934)3.28296617
99fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.27355554
100alkaloid metabolic process (GO:0009820)3.26450781
101cell communication involved in cardiac conduction (GO:0086065)3.25857084
102regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.25225278
103positive regulation of actin filament depolymerization (GO:0030836)3.24850623
104positive regulation of epidermal cell differentiation (GO:0045606)3.24844554
105ethanol oxidation (GO:0006069)3.24822323
106lipopolysaccharide biosynthetic process (GO:0009103)3.23259372
107positive regulation of cGMP biosynthetic process (GO:0030828)3.22750127
108N-acetylglucosamine metabolic process (GO:0006044)3.22691018
109lung cell differentiation (GO:0060479)3.22619819
110ceramide catabolic process (GO:0046514)3.19024378
111glutamine family amino acid biosynthetic process (GO:0009084)3.18784491
112lipoprotein metabolic process (GO:0042157)3.17700502
113midgut development (GO:0007494)3.17019138
114drinking behavior (GO:0042756)3.16659580
115cellular response to hepatocyte growth factor stimulus (GO:0035729)3.16655433
116response to hepatocyte growth factor (GO:0035728)3.16655433
117cellular response to nitric oxide (GO:0071732)3.16047443
118sexual reproduction (GO:0019953)3.12467102
119renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.12390820
120vitamin transport (GO:0051180)3.11297939
121keratan sulfate biosynthetic process (GO:0018146)3.11014178
122protein-lipid complex assembly (GO:0065005)3.09276546
123lung epithelial cell differentiation (GO:0060487)3.08729599
124glucosamine-containing compound metabolic process (GO:1901071)3.08434061
125bile acid metabolic process (GO:0008206)3.07891168
126regulation of pH (GO:0006885)3.07702102
127negative regulation of cell fate commitment (GO:0010454)3.06864609
128auditory receptor cell differentiation (GO:0042491)3.06211499
129thrombin receptor signaling pathway (GO:0070493)3.05438281
130eosinophil chemotaxis (GO:0048245)3.05009425
131sphingolipid catabolic process (GO:0030149)3.04763554
132drug transport (GO:0015893)3.03156307
133response to nitric oxide (GO:0071731)3.02366982
134cGMP biosynthetic process (GO:0006182)2.99934522
135sphingomyelin metabolic process (GO:0006684)2.98911358
136citrulline biosynthetic process (GO:0019240)2.98479556
137sodium ion export (GO:0071436)2.97932370
138glycerol metabolic process (GO:0006071)2.97060329
139cytoskeletal anchoring at plasma membrane (GO:0007016)2.94602949
140adhesion of symbiont to host (GO:0044406)2.93887372
141membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.93414519
142regulation of respiratory burst (GO:0060263)2.91923267
143galactose metabolic process (GO:0006012)2.91508423
144desmosome organization (GO:0002934)2.89992874
145regulation of actin nucleation (GO:0051125)2.88248286
146negative regulation of cholesterol transport (GO:0032375)2.86835269
147negative regulation of sterol transport (GO:0032372)2.86835269
148regulation of intracellular pH (GO:0051453)2.86724658
149hypotonic response (GO:0006971)2.84978854
150GDP-mannose metabolic process (GO:0019673)2.81829518
151striated muscle atrophy (GO:0014891)2.81061446
152homocysteine metabolic process (GO:0050667)2.78888171
153columnar/cuboidal epithelial cell development (GO:0002066)2.75976529
154cardiac conduction (GO:0061337)2.75422932
155phospholipid translocation (GO:0045332)2.74220291
156lipid translocation (GO:0034204)2.74220291
157phospholipid scrambling (GO:0017121)2.71229763
158leukocyte tethering or rolling (GO:0050901)2.68784889
159glycosylceramide metabolic process (GO:0006677)2.68753865
160lipopolysaccharide metabolic process (GO:0008653)2.67816725
161keratan sulfate metabolic process (GO:0042339)2.62216158
162regulation of membrane lipid distribution (GO:0097035)2.60214856
163protein autoprocessing (GO:0016540)2.60077440
164positive regulation of epidermis development (GO:0045684)2.59830579
165nucleotide transmembrane transport (GO:1901679)2.59695725
166regulation of heart rate by cardiac conduction (GO:0086091)2.59151049
167membrane repolarization during action potential (GO:0086011)2.58395812
168phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.57968648
169detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.57810931
170regulation of cellular pH (GO:0030641)2.57746726
171epithelial cell-cell adhesion (GO:0090136)2.56488217
172modified amino acid transport (GO:0072337)2.56374066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.34500252
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.62483137
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.21198917
4SOX2_27498859_Chip-Seq_STOMACH_Mouse3.74590100
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.03294017
6SOX2_20726797_ChIP-Seq_SW620_Human2.91235500
7GATA4_25053715_ChIP-Seq_YYC3_Human2.89768303
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.80403324
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.79006424
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.75676394
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.75299712
12GATA6_25053715_ChIP-Seq_YYC3_Human2.58834781
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.33711012
14FOXO3_23340844_ChIP-Seq_DLD1_Human2.27656102
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.26980331
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.25920579
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.17287220
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.09736694
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.06027279
20PPARA_22158963_ChIP-Seq_LIVER_Mouse2.05621973
21PPAR_26484153_Chip-Seq_NCI-H1993_Human2.01450758
22EGR1_23403033_ChIP-Seq_LIVER_Mouse1.97492166
23RUNX1_27514584_Chip-Seq_MCF-7_Human1.96739544
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.96640966
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89910002
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.86859897
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.86692643
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.85150258
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.84706475
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.83238427
31ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.78721702
32RXR_22158963_ChIP-Seq_LIVER_Mouse1.77543623
33KLF5_25053715_ChIP-Seq_YYC3_Human1.68425073
34BCAT_22108803_ChIP-Seq_LS180_Human1.63558663
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62980116
36GATA1_22025678_ChIP-Seq_K562_Human1.62359461
37TCF4_18268006_ChIP-ChIP_LS174T_Human1.59612931
38RACK7_27058665_Chip-Seq_MCF-7_Human1.59260721
39* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.58476500
40DROSHA_22980978_ChIP-Seq_HELA_Human1.58251033
41ZNF263_19887448_ChIP-Seq_K562_Human1.58164549
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56383179
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55074365
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54744417
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54491841
46ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.53718705
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53545035
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.51888905
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46649781
50CLOCK_20551151_ChIP-Seq_293T_Human1.34577725
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34337740
52FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.31569903
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28285785
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.28045209
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26689491
56* GATA2_19941826_ChIP-Seq_K562_Human1.25727295
57STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23727541
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21634717
59AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.21055032
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17793076
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16792805
62FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15727986
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14626459
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14204587
65ATF3_27146783_Chip-Seq_COLON_Human1.13502234
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12842789
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10071996
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10071996
69FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08944349
70VDR_22108803_ChIP-Seq_LS180_Human1.08090727
71LXR_22292898_ChIP-Seq_THP-1_Human1.06890468
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06604302
73CREB1_26743006_Chip-Seq_LNCaP_Human1.06311363
74SA1_27219007_Chip-Seq_Bcells_Human1.05554797
75FOXA1_25552417_ChIP-Seq_VCAP_Human1.05220549
76JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05198552
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.04248665
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03466677
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02515112
80ELF5_23300383_ChIP-Seq_T47D_Human1.01891967
81CDX2_22108803_ChIP-Seq_LS180_Human1.01082350
82ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00303638
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00235574
84GATA3_24758297_ChIP-Seq_MCF-7_Human0.99890938
85PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99047771
86BCL6_27268052_Chip-Seq_Bcells_Human0.98796627
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96960471
88BCOR_27268052_Chip-Seq_Bcells_Human0.96941658
89GATA1_19941826_ChIP-Seq_K562_Human0.96933764
90AR_21909140_ChIP-Seq_LNCAP_Human0.96553513
91FOXA2_19822575_ChIP-Seq_HepG2_Human0.93809034
92CEBPB_22108803_ChIP-Seq_LS180_Human0.93514537
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93450587
94HNF4A_19822575_ChIP-Seq_HepG2_Human0.92312571
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91548334
96RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90436422
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89778649
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.89735311
99VDR_24763502_ChIP-Seq_THP-1_Human0.89609409
100CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88956514
101SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88235676
102* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88163764
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87925123
104* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87374177
105* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86814896
106STAT1_20625510_ChIP-Seq_HELA_Human0.86424093
107NANOG_20526341_ChIP-Seq_ESCs_Human0.86205592
108DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85973002
109PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85384708
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85088079
111CTCF_27219007_Chip-Seq_Bcells_Human0.84684799
112NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84495491
113VDR_24787735_ChIP-Seq_THP-1_Human0.84414345
114AHR_22903824_ChIP-Seq_MCF-7_Human0.83998690
115IRF8_27001747_Chip-Seq_BMDM_Mouse0.83943799
116EGR1_19032775_ChIP-ChIP_M12_Human0.82627386
117CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81679897
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81444337
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79868571
120SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.79740497
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78774717
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78009544
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76803593
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76709892
125P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75625769
126RXR_22108803_ChIP-Seq_LS180_Human0.75586732
127CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.75532553
128IKZF1_21737484_ChIP-ChIP_HCT116_Human0.75463730
129ELK3_25401928_ChIP-Seq_HUVEC_Human0.74797344
130* CJUN_26792858_Chip-Seq_BT549_Human0.74455920
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73605290
132TCF3_18692474_ChIP-Seq_MEFs_Mouse0.72815179
133PIAS1_25552417_ChIP-Seq_VCAP_Human0.71909674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.27964367
2MP0003866_abnormal_defecation4.97344577
3MP0005360_urolithiasis4.77667104
4MP0001663_abnormal_digestive_system4.44904853
5MP0001666_abnormal_nutrient_absorption4.17402988
6MP0005381_digestive/alimentary_phenotyp3.92558101
7MP0004264_abnormal_extraembryonic_tissu3.90354096
8MP0010155_abnormal_intestine_physiology3.73647545
9MP0001873_stomach_inflammation3.43537417
10MP0000462_abnormal_digestive_system3.33523103
11MP0000490_abnormal_crypts_of2.94727413
12MP0005085_abnormal_gallbladder_physiolo2.93000852
13MP0004043_abnormal_pH_regulation2.90619902
14MP0006054_spinal_hemorrhage2.87436420
15MP0000477_abnormal_intestine_morphology2.76848043
16MP0001664_abnormal_digestion2.65262666
17MP0000537_abnormal_urethra_morphology2.62461614
18MP0003705_abnormal_hypodermis_morpholog2.50874640
19MP0010352_gastrointestinal_tract_polyps2.46027856
20MP0003868_abnormal_feces_composition2.44256794
21MP0005409_darkened_coat_color2.19709787
22MP0003252_abnormal_bile_duct2.09857971
23MP0008875_abnormal_xenobiotic_pharmacok2.08447500
24MP0005365_abnormal_bile_salt1.91564766
25MP0000465_gastrointestinal_hemorrhage1.91041293
26MP0005166_decreased_susceptibility_to1.90679993
27MP0002822_catalepsy1.88028187
28MP0002139_abnormal_hepatobiliary_system1.83298200
29MP0002277_abnormal_respiratory_mucosa1.82068024
30MP0005167_abnormal_blood-brain_barrier1.81672320
31MP0003283_abnormal_digestive_organ1.81110835
32MP0003300_gastrointestinal_ulcer1.76033387
33MP0000467_abnormal_esophagus_morphology1.58820883
34MP0000538_abnormal_urinary_bladder1.55755470
35MP0004858_abnormal_nervous_system1.55017060
36MP0004147_increased_porphyrin_level1.53762235
37MP0000678_abnormal_parathyroid_gland1.50902283
38MP0010329_abnormal_lipoprotein_level1.44697305
39MP0008004_abnormal_stomach_pH1.43935732
40MP0001764_abnormal_homeostasis1.42959011
41MP0001765_abnormal_ion_homeostasis1.41712732
42MP0001188_hyperpigmentation1.40361602
43MP0004782_abnormal_surfactant_physiolog1.38168064
44MP0005670_abnormal_white_adipose1.33119552
45MP0005377_hearing/vestibular/ear_phenot1.30636550
46MP0003878_abnormal_ear_physiology1.30636550
47MP0003183_abnormal_peptide_metabolism1.26543815
48MP0009764_decreased_sensitivity_to1.24077679
49MP0010678_abnormal_skin_adnexa1.23834392
50MP0009840_abnormal_foam_cell1.21875746
51MP0000470_abnormal_stomach_morphology1.20495391
52MP0002796_impaired_skin_barrier1.18651629
53MP0005310_abnormal_salivary_gland1.17029482
54MP0005165_increased_susceptibility_to1.13743164
55MP0001849_ear_inflammation1.13201931
56MP0009643_abnormal_urine_homeostasis1.06961209
57MP0003724_increased_susceptibility_to1.05828760
58MP0001501_abnormal_sleep_pattern1.05325963
59MP0002166_altered_tumor_susceptibility0.99295569
60MP0005636_abnormal_mineral_homeostasis0.97588693
61MP0002876_abnormal_thyroid_physiology0.97165132
62MP0002138_abnormal_hepatobiliary_system0.96957174
63MP0009379_abnormal_foot_pigmentation0.96575853
64MP0004019_abnormal_vitamin_homeostasis0.93060455
65MP0009785_altered_susceptibility_to0.91513649
66MP0003303_peritoneal_inflammation0.88906826
67MP0005584_abnormal_enzyme/coenzyme_acti0.87673491
68MP0003191_abnormal_cellular_cholesterol0.86854592
69MP0002971_abnormal_brown_adipose0.86198655
70MP0005187_abnormal_penis_morphology0.86000653
71MP0003453_abnormal_keratinocyte_physiol0.84491327
72MP0003806_abnormal_nucleotide_metabolis0.84144638
73MP0008872_abnormal_physiological_respon0.82641020
74MP0005535_abnormal_body_temperature0.82116235
75MP0005025_abnormal_response_to0.80528903
76MP0003718_maternal_effect0.80431381
77MP0000516_abnormal_urinary_system0.79416594
78MP0005367_renal/urinary_system_phenotyp0.79416594
79MP0001835_abnormal_antigen_presentation0.79158236
80MP0005387_immune_system_phenotype0.76882527
81MP0001790_abnormal_immune_system0.76882527
82MP0004484_altered_response_of0.75270122
83MP0001845_abnormal_inflammatory_respons0.74138679
84MP0006082_CNS_inflammation0.73899248
85MP0009115_abnormal_fat_cell0.73744745
86MP0004947_skin_inflammation0.73568985
87MP0003436_decreased_susceptibility_to0.73458379
88MP0008469_abnormal_protein_level0.70382166
89MP0005501_abnormal_skin_physiology0.70095620
90MP0002909_abnormal_adrenal_gland0.68829650
91MP0003091_abnormal_cell_migration0.68031239
92MP0003329_amyloid_beta_deposits0.67944480
93MP0002006_tumorigenesis0.67844015
94MP0002118_abnormal_lipid_homeostasis0.66671963
95MP0009780_abnormal_chondrocyte_physiolo0.66158660
96MP0001485_abnormal_pinna_reflex0.66046490
97MP0002009_preneoplasia0.65548202
98MP0002396_abnormal_hematopoietic_system0.64558527
99MP0005448_abnormal_energy_balance0.64187122
100MP0000609_abnormal_liver_physiology0.64178943
101MP0002136_abnormal_kidney_physiology0.63397270
102MP0009642_abnormal_blood_homeostasis0.62769734
103MP0000604_amyloidosis0.62485306
104MP0000230_abnormal_systemic_arterial0.62464655
105MP0003315_abnormal_perineum_morphology0.61242976
106MP0002837_dystrophic_cardiac_calcinosis0.60730803
107MP0002098_abnormal_vibrissa_morphology0.60515968
108MP0009333_abnormal_splenocyte_physiolog0.60279174
109MP0005319_abnormal_enzyme/_coenzyme0.59708820
110MP0000249_abnormal_blood_vessel0.59063111
111MP0003075_altered_response_to0.58930658
112MP0009384_cardiac_valve_regurgitation0.57784562
113MP0002254_reproductive_system_inflammat0.56378055
114MP0002060_abnormal_skin_morphology0.56107071
115MP0003566_abnormal_cell_adhesion0.56039779
116MP0001216_abnormal_epidermal_layer0.54858435
117MP0005451_abnormal_body_composition0.54728981
118MP0004185_abnormal_adipocyte_glucose0.52776480
119MP0004270_analgesia0.52629234
120MP0001533_abnormal_skeleton_physiology0.52568394
121MP0001881_abnormal_mammary_gland0.52404138
122MP0002148_abnormal_hypersensitivity_rea0.52298253
123MP0002089_abnormal_postnatal_growth/wei0.51593976
124MP0010386_abnormal_urinary_bladder0.50785267
125MP0005058_abnormal_lysosome_morphology0.50316909
126MP0003879_abnormal_hair_cell0.49708252
127MP0001800_abnormal_humoral_immune0.48962912
128MP0003045_fibrosis0.47635642
129MP0005666_abnormal_adipose_tissue0.47583921
130MP0000613_abnormal_salivary_gland0.46599487
131MP0005332_abnormal_amino_acid0.46126421
132MP0002896_abnormal_bone_mineralization0.46038311
133MP0001756_abnormal_urination0.45064847
134MP0008873_increased_physiological_sensi0.44383490
135MP0005084_abnormal_gallbladder_morpholo0.38222994
136MP0010771_integument_phenotype0.38152013
137MP0005257_abnormal_intraocular_pressure0.37836519
138MP0005266_abnormal_metabolism0.37076310
139MP0003950_abnormal_plasma_membrane0.37050363

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.75418458
2Right ventricular cardiomyopathy (HP:0011663)7.43632644
3Hyperactive renin-angiotensin system (HP:0000841)6.86379299
4Metabolic alkalosis (HP:0200114)5.71946012
5Abdominal distention (HP:0003270)5.03400744
6Malnutrition (HP:0004395)4.77909882
7Abnormality of chloride homeostasis (HP:0011422)4.68378173
8Systemic lupus erythematosus (HP:0002725)4.20383430
9Abnormality of renin-angiotensin system (HP:0000847)4.09482844
10Widely patent fontanelles and sutures (HP:0004492)4.04208235
11Gastrointestinal dysmotility (HP:0002579)3.97275805
12Flat acetabular roof (HP:0003180)3.96663671
13Mildly elevated creatine phosphokinase (HP:0008180)3.83804309
14Confusion (HP:0001289)3.80033449
15Abnormality of the 1st metacarpal (HP:0010009)3.69423429
16Conjugated hyperbilirubinemia (HP:0002908)3.66447132
17Abnormal tarsal ossification (HP:0008369)3.66195761
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.64624924
19Abnormality of vitamin metabolism (HP:0100508)3.57490987
20Chronic diarrhea (HP:0002028)3.39778523
21Pigmentary retinal degeneration (HP:0001146)3.31808628
22Palpitations (HP:0001962)3.24737715
23Hyperaldosteronism (HP:0000859)3.18972317
24Nausea (HP:0002018)3.18885755
25Abnormal foot bone ossification (HP:0010675)3.14427474
26Abnormality of urine glucose concentration (HP:0011016)3.14309205
27Glycosuria (HP:0003076)3.14309205
28Wide cranial sutures (HP:0010537)3.07069287
29Hyperglycinuria (HP:0003108)3.06783254
30Micronodular cirrhosis (HP:0001413)3.03604170
31Decreased circulating renin level (HP:0003351)3.02374602
32Rectal prolapse (HP:0002035)3.00708876
33Proximal tubulopathy (HP:0000114)2.98406311
34Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.89690529
35Short 1st metacarpal (HP:0010034)2.89690529
36Eczematoid dermatitis (HP:0000976)2.89074134
37Syncope (HP:0001279)2.88261406
38Aortic aneurysm (HP:0004942)2.87610588
39Nephrolithiasis (HP:0000787)2.85540880
40Intrahepatic cholestasis (HP:0001406)2.84605512
41Abnormality of the distal phalanx of the thumb (HP:0009617)2.81598673
42Hyperparathyroidism (HP:0000843)2.81468806
43Woolly hair (HP:0002224)2.75934948
44Hemorrhage of the eye (HP:0011885)2.75268315
45Hydroxyprolinuria (HP:0003080)2.73677920
46Abnormality of proline metabolism (HP:0010907)2.73677920
47Alkalosis (HP:0001948)2.73014993
48Xanthomatosis (HP:0000991)2.65255633
49Pustule (HP:0200039)2.64803527
50Abnormality of glycine metabolism (HP:0010895)2.64250372
51Abnormality of serine family amino acid metabolism (HP:0010894)2.64250372
52Ventricular fibrillation (HP:0001663)2.63499959
53Hyperammonemia (HP:0001987)2.62142935
54Dehydration (HP:0001944)2.61644965
55Goiter (HP:0000853)2.59946743
56Increased purine levels (HP:0004368)2.58021095
57Hyperuricemia (HP:0002149)2.58021095
58Autoimmune thrombocytopenia (HP:0001973)2.57962412
59Hypophosphatemia (HP:0002148)2.56037656
60Fat malabsorption (HP:0002630)2.55844701
61Cupped ribs (HP:0000887)2.52911481
62Steatorrhea (HP:0002570)2.52891400
63Congenital sensorineural hearing impairment (HP:0008527)2.52727634
64Ureteral stenosis (HP:0000071)2.51709164
65Potter facies (HP:0002009)2.51461699
66Facial shape deformation (HP:0011334)2.51461699
67Abnormality of carpal bone ossification (HP:0006257)2.50463662
68Posterior subcapsular cataract (HP:0007787)2.50455311
69Abnormal biliary tract morphology (HP:0012440)2.50153748
70Hypotension (HP:0002615)2.45547628
71Short phalanx of the thumb (HP:0009660)2.45109531
72Abnormality of monocarboxylic acid metabolism (HP:0010996)2.44350646
73Abnormality of the gastric mucosa (HP:0004295)2.42260968
74Abnormality of small intestinal villus morphology (HP:0011472)2.41125214
75Villous atrophy (HP:0011473)2.41125214
76Focal segmental glomerulosclerosis (HP:0000097)2.37820463
77Progressive sensorineural hearing impairment (HP:0000408)2.36825910
78Milia (HP:0001056)2.35678361
79Biliary tract neoplasm (HP:0100574)2.35428510
80Megaloblastic anemia (HP:0001889)2.34795070
81Ureteral obstruction (HP:0006000)2.31060667
82Petechiae (HP:0000967)2.30982594
83Enlarged epiphyses (HP:0010580)2.30560812
84Hypokalemia (HP:0002900)2.29807378
85Abnormal cartilage morphology (HP:0002763)2.28276510
86Pili torti (HP:0003777)2.27918706
87Hoarse voice (HP:0001609)2.26428553
88Ventricular tachycardia (HP:0004756)2.26203539
89Flattened epiphyses (HP:0003071)2.26105087
90Abnormality of purine metabolism (HP:0004352)2.26100874
91Hyponatremia (HP:0002902)2.24482008
92Glomerulonephritis (HP:0000099)2.23246457
93Atrophic scars (HP:0001075)2.22645174
94Renal tubular acidosis (HP:0001947)2.22430314
95Limb-girdle muscle atrophy (HP:0003797)2.22154683
96Hypolipoproteinemia (HP:0010981)2.21529694
97Abnormality of the 2nd finger (HP:0004100)2.20596749
98Hyperphosphatemia (HP:0002905)2.20351161
99Hypobetalipoproteinemia (HP:0003563)2.19409329
100Acanthocytosis (HP:0001927)2.19000843
101Delayed epiphyseal ossification (HP:0002663)2.14842623
102Myopathic facies (HP:0002058)2.14739419
103Bundle branch block (HP:0011710)2.14674719
104Abnormality of complement system (HP:0005339)2.14401545
105Aortic dissection (HP:0002647)2.14026434
106Fragile nails (HP:0001808)2.12336995
107Microretrognathia (HP:0000308)2.08935968
108Symphalangism affecting the phalanges of the hand (HP:0009773)2.08495158
109Abnormality of nucleobase metabolism (HP:0010932)2.08444647
110Abnormality of the costochondral junction (HP:0000919)2.07974620
111Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07577216
112Dicarboxylic aciduria (HP:0003215)2.07577216
113Cerebral palsy (HP:0100021)2.06964594
114Pancreatitis (HP:0001733)2.05729988
115Adrenal overactivity (HP:0002717)2.05697377
116Abnormal urine phosphate concentration (HP:0012599)2.05272241
117Abnormal vertebral ossification (HP:0100569)2.05019615
118Abnormality of aspartate family amino acid metabolism (HP:0010899)2.03108293
119Esophageal varix (HP:0002040)2.02689950
120Protuberant abdomen (HP:0001538)2.02402305
121Cone-rod dystrophy (HP:0000548)2.01330587
122Complement deficiency (HP:0004431)2.01140122
123Metabolic acidosis (HP:0001942)2.00993788
124Nephritis (HP:0000123)2.00864521
125Abnormal glucose tolerance (HP:0001952)2.00862093
126Progressive hearing impairment (HP:0001730)2.00388325
127Abnormality of the vitamin B12 metabolism (HP:0004341)1.99826344
128Abnormal ossification of hand bones (HP:0005921)1.98456325
129Curly hair (HP:0002212)1.98431163
130Gingivitis (HP:0000230)1.98133944
131Ventricular arrhythmia (HP:0004308)1.97823520
132Neonatal short-limb short stature (HP:0008921)1.97491993
133Hyperphosphaturia (HP:0003109)1.97479783
134Late onset (HP:0003584)1.96130635
135Abnormal hand bone ossification (HP:0010660)1.94370383
136Short hallux (HP:0010109)1.94076358
137Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.91522113
138Abnormality of potassium homeostasis (HP:0011042)1.91396460
139Neoplasm of the rectum (HP:0100743)1.91263700
140Growth hormone excess (HP:0000845)1.90318887
141Thin bony cortex (HP:0002753)1.89171939
142Abnormality of magnesium homeostasis (HP:0004921)1.87655559
143Subcapsular cataract (HP:0000523)1.85471375
144Abnormality of vitamin B metabolism (HP:0004340)1.84991931
145Plantar hyperkeratosis (HP:0007556)1.84916099
146Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.84131494
147Vertebral hypoplasia (HP:0008417)1.84131494
148Symptomatic seizures (HP:0011145)1.83975095
149Spinal cord compression (HP:0002176)1.83238090
150Onycholysis (HP:0001806)1.82354197
151Multiple lipomas (HP:0001012)1.81651324
152Vertebral clefting (HP:0008428)1.81610731
153Vascular calcification (HP:0004934)1.81008178
154Epidermoid cyst (HP:0200040)1.80162522
155Abnormality of sodium homeostasis (HP:0010931)1.80047347
156Glomerulosclerosis (HP:0000096)1.79306263
157Fragile skin (HP:0001030)1.78107670
158Segmental peripheral demyelination/remyelination (HP:0003481)1.76897315
159Gout (HP:0001997)1.76142735
160Bone pain (HP:0002653)1.73367300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.46907572
2LMTK25.52301732
3MST45.09028040
4FRK4.76398451
5MST1R4.68211565
6MYLK3.46585395
7TESK13.01663753
8PRKG22.62582199
9PIK3CA2.61255448
10NME12.58549020
11MAP2K22.47543064
12RIPK12.21391442
13PTK62.19646166
14MAP3K22.09598213
15OXSR12.02953742
16FGFR42.02329709
17EPHB21.98742025
18KSR21.92423392
19EPHA31.76128028
20MET1.73518404
21LIMK11.72738334
22MAP3K101.61034932
23GRK61.55054589
24ERN11.46534796
25DMPK1.43203607
26MAP2K11.37697030
27STK101.29367170
28PRPF4B1.28763208
29FER1.24093324
30TNIK1.22459276
31RIPK41.21584872
32MAP4K11.18344209
33DDR21.18187764
34FGFR31.16347828
35PAK41.16076352
36MAP3K91.15331903
37PTK21.08239982
38LRRK21.03663786
39TAOK11.01216387
40EPHA21.00947284
41PKN20.95691866
42ERBB40.95436507
43NLK0.93754191
44EPHB10.92535742
45TTN0.91670434
46MAP3K70.91095305
47PAK20.86753328
48PAK30.86454980
49PRKCI0.86064128
50CAMK2D0.83864397
51MATK0.82492876
52EPHA40.82091732
53RPS6KB20.81718072
54MAP3K80.81583799
55EEF2K0.80363966
56PRKAA20.80281301
57MAP3K10.80169701
58TRIB30.79249466
59ERBB20.78510688
60PIK3CG0.77140346
61MAP3K120.73415274
62LATS10.65761212
63ROCK10.64451687
64BMX0.64356773
65CAMK2G0.60466934
66IRAK10.60333206
67MAP3K130.60251650
68BMPR20.59504769
69JAK10.58287580
70WNK40.58231788
71MAP2K60.58095509
72CAMK2B0.56338950
73NUAK10.55739086
74PRKAA10.55592423
75ICK0.53526550
76MAPKAPK30.53326128
77PAK10.53272134
78CASK0.53097882
79ARAF0.52425477
80MAPK110.51983465
81RET0.50637091
82MAP3K110.50620667
83ABL20.50147924
84TBK10.49172068
85PDPK10.48080808
86JAK20.47012887
87SCYL20.46953968
88DAPK30.46042992
89PRKCZ0.45118180
90CSK0.44473522
91YES10.44324663
92CDC42BPA0.43313167
93IKBKE0.43015971
94CAMKK10.42983012
95CDK190.42955086
96ROCK20.41878898
97FYN0.41760682
98PIM10.41574651
99ZAP700.40597063
100SRC0.40265996
101TAOK30.39813957
102MAP3K140.37869216
103SMG10.37026614
104TESK20.36930104
105MAPKAPK20.35407822
106STK390.34380473
107PDK30.33699748
108PDK40.33699748
109PRKCD0.33313731
110PDK10.32043535
111GRK10.31842123
112PDGFRA0.31341821
113PRKCA0.31005164
114JAK30.30330523
115NEK10.29947726
116PIM20.29500274
117CDK60.29045391
118CSF1R0.27581957
119GSK3A0.27017965
120PRKACG0.26514169
121MAP3K30.25910690
122STK240.25668519
123LYN0.25509478
124KIT0.25383126
125ITK0.25291140
126CSNK1A10.24602331
127BTK0.24302809
128SYK0.24064807
129RPS6KA20.23946129
130PDK20.23705428
131DYRK1B0.23037718
132AKT30.23017297
133TYK20.21992883
134NEK60.21845000
135KSR10.21238804
136ALK0.20213328
137MELK0.19471334
138LCK0.18094656
139IGF1R0.18090640

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.75215063
2Mineral absorption_Homo sapiens_hsa049784.45736333
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.96792274
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.89866430
5Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.67501803
6Fat digestion and absorption_Homo sapiens_hsa049753.38289330
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.95656983
8Bile secretion_Homo sapiens_hsa049762.63405177
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.56556877
10Renin-angiotensin system_Homo sapiens_hsa046142.33086112
11Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.10612149
12Drug metabolism - other enzymes_Homo sapiens_hsa009831.82603482
13Retinol metabolism_Homo sapiens_hsa008301.77341626
14Protein digestion and absorption_Homo sapiens_hsa049741.61461927
15Fructose and mannose metabolism_Homo sapiens_hsa000511.59659857
16Histidine metabolism_Homo sapiens_hsa003401.58897065
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57022041
18Galactose metabolism_Homo sapiens_hsa000521.46611800
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.45691754
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43096903
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38940870
22Caffeine metabolism_Homo sapiens_hsa002321.37769333
23Asthma_Homo sapiens_hsa053101.34849729
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31080301
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30026701
26* Pancreatic secretion_Homo sapiens_hsa049721.26379580
27Vitamin digestion and absorption_Homo sapiens_hsa049771.26150232
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23079997
29Thyroid hormone synthesis_Homo sapiens_hsa049181.21190884
30Linoleic acid metabolism_Homo sapiens_hsa005911.16682876
31Carbohydrate digestion and absorption_Homo sapiens_hsa049731.16505971
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14353704
33Tight junction_Homo sapiens_hsa045301.13893475
34Starch and sucrose metabolism_Homo sapiens_hsa005001.13352839
35Vibrio cholerae infection_Homo sapiens_hsa051101.08707864
36PPAR signaling pathway_Homo sapiens_hsa033201.05748776
37Tryptophan metabolism_Homo sapiens_hsa003801.03764702
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02074779
39Fatty acid degradation_Homo sapiens_hsa000711.01879920
40Allograft rejection_Homo sapiens_hsa053300.99696706
41Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97011128
42Glycerolipid metabolism_Homo sapiens_hsa005610.94009444
43Nitrogen metabolism_Homo sapiens_hsa009100.93974650
44Autoimmune thyroid disease_Homo sapiens_hsa053200.93201354
45Glutathione metabolism_Homo sapiens_hsa004800.92326836
46Gastric acid secretion_Homo sapiens_hsa049710.89980092
47Graft-versus-host disease_Homo sapiens_hsa053320.88691865
48Folate biosynthesis_Homo sapiens_hsa007900.87871266
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.82668029
50Butanoate metabolism_Homo sapiens_hsa006500.81253464
51Staphylococcus aureus infection_Homo sapiens_hsa051500.79729814
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79065676
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76263098
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76038319
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.75178619
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73827738
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72713825
58Salivary secretion_Homo sapiens_hsa049700.72687328
59Type I diabetes mellitus_Homo sapiens_hsa049400.68623890
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.67459098
61Thyroid cancer_Homo sapiens_hsa052160.65354220
62Salmonella infection_Homo sapiens_hsa051320.64953177
63Carbon metabolism_Homo sapiens_hsa012000.62955712
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62879492
65Pyruvate metabolism_Homo sapiens_hsa006200.62432593
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60880718
67Ether lipid metabolism_Homo sapiens_hsa005650.60821140
68Other glycan degradation_Homo sapiens_hsa005110.58847355
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.58025604
70Arachidonic acid metabolism_Homo sapiens_hsa005900.55693836
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52950282
72Adherens junction_Homo sapiens_hsa045200.52679675
73Amoebiasis_Homo sapiens_hsa051460.51591279
74Antigen processing and presentation_Homo sapiens_hsa046120.48869286
75Arginine biosynthesis_Homo sapiens_hsa002200.48168553
76Pentose phosphate pathway_Homo sapiens_hsa000300.45951290
77N-Glycan biosynthesis_Homo sapiens_hsa005100.45788412
78Bladder cancer_Homo sapiens_hsa052190.45265813
79ABC transporters_Homo sapiens_hsa020100.45262777
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45236748
81Arginine and proline metabolism_Homo sapiens_hsa003300.44372408
82Hepatitis C_Homo sapiens_hsa051600.43761945
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43444841
84Peroxisome_Homo sapiens_hsa041460.42330364
85Leishmaniasis_Homo sapiens_hsa051400.41499793
86Sphingolipid metabolism_Homo sapiens_hsa006000.39528539
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39407376
88Propanoate metabolism_Homo sapiens_hsa006400.38506954
89Tyrosine metabolism_Homo sapiens_hsa003500.36497927
90Sulfur relay system_Homo sapiens_hsa041220.34600460
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34570747
92Insulin secretion_Homo sapiens_hsa049110.34037250
93Fatty acid biosynthesis_Homo sapiens_hsa000610.33883131
94Fatty acid metabolism_Homo sapiens_hsa012120.33121306
95GnRH signaling pathway_Homo sapiens_hsa049120.31378047
96beta-Alanine metabolism_Homo sapiens_hsa004100.30857075
97Chemical carcinogenesis_Homo sapiens_hsa052040.29785736
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.28699141
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.28540145
100Viral myocarditis_Homo sapiens_hsa054160.27430856
101Pertussis_Homo sapiens_hsa051330.27207779
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26262028
103VEGF signaling pathway_Homo sapiens_hsa043700.24732031
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24153219
105Insulin resistance_Homo sapiens_hsa049310.23130714
106Dorso-ventral axis formation_Homo sapiens_hsa043200.22418384
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20928675
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19270223
109African trypanosomiasis_Homo sapiens_hsa051430.19197687
110Phenylalanine metabolism_Homo sapiens_hsa003600.18862945
111Metabolic pathways_Homo sapiens_hsa011000.18485034
112Toxoplasmosis_Homo sapiens_hsa051450.18024457
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.17879750
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.17837434
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16990431
116Cardiac muscle contraction_Homo sapiens_hsa042600.16059215
117Type II diabetes mellitus_Homo sapiens_hsa049300.15859444
118Long-term depression_Homo sapiens_hsa047300.15566834
119Platelet activation_Homo sapiens_hsa046110.13922192
120Cocaine addiction_Homo sapiens_hsa050300.13376515
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13288519
122Alzheimers disease_Homo sapiens_hsa050100.12776383
123Biosynthesis of amino acids_Homo sapiens_hsa012300.11869298
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.11493368
125Gap junction_Homo sapiens_hsa045400.11271457
126Hematopoietic cell lineage_Homo sapiens_hsa046400.10913540
127Focal adhesion_Homo sapiens_hsa045100.10140113
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.09701753
129* Renin secretion_Homo sapiens_hsa049240.08427200
130Influenza A_Homo sapiens_hsa051640.07538121
131Chemokine signaling pathway_Homo sapiens_hsa040620.07533968
132Tuberculosis_Homo sapiens_hsa051520.07204782
133Glucagon signaling pathway_Homo sapiens_hsa049220.06449127

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