CLCA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.55832410
2establishment of skin barrier (GO:0061436)7.81641311
3regulation of water loss via skin (GO:0033561)7.17622589
4keratinization (GO:0031424)6.84857163
5surfactant homeostasis (GO:0043129)6.09494031
6positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.96253471
7regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.96253471
8establishment of planar polarity (GO:0001736)5.92783023
9establishment of tissue polarity (GO:0007164)5.92783023
10keratinocyte differentiation (GO:0030216)5.90567589
11keratinocyte proliferation (GO:0043616)5.89674719
12sphingoid metabolic process (GO:0046519)5.85397218
13regulation of keratinocyte proliferation (GO:0010837)5.70321635
14gap junction assembly (GO:0016264)5.44399166
15lateral sprouting from an epithelium (GO:0060601)5.30831069
16interferon-gamma secretion (GO:0072643)5.28251576
17sphingosine metabolic process (GO:0006670)5.06225687
18epithelial cell differentiation involved in prostate gland development (GO:0060742)5.01724104
19hair cycle (GO:0042633)4.98431865
20molting cycle (GO:0042303)4.98431865
21polarized epithelial cell differentiation (GO:0030859)4.96724403
22dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.92082928
23multicellular organismal water homeostasis (GO:0050891)4.87173925
24viral transcription (GO:0019083)4.85929050
25ribosomal small subunit biogenesis (GO:0042274)4.85668169
26glucosamine-containing compound catabolic process (GO:1901072)4.78949057
27translational termination (GO:0006415)4.57866166
28regulation of phospholipase A2 activity (GO:0032429)4.55237775
29bundle of His cell to Purkinje myocyte communication (GO:0086069)4.54310292
30cell adhesion mediated by integrin (GO:0033627)4.54035465
31diol metabolic process (GO:0034311)4.49525866
32epidermal cell differentiation (GO:0009913)4.48667059
33prostanoid biosynthetic process (GO:0046457)4.46585952
34prostaglandin biosynthetic process (GO:0001516)4.46585952
35intermediate filament organization (GO:0045109)4.45108647
36intermediate filament-based process (GO:0045103)4.44713196
37keratinocyte development (GO:0003334)4.42781203
38natural killer cell activation involved in immune response (GO:0002323)4.42644606
39regulation of hair follicle development (GO:0051797)4.41371816
40ectoderm development (GO:0007398)4.33871498
41regulation of MHC class I biosynthetic process (GO:0045343)4.33077512
42regulation of cell proliferation involved in kidney development (GO:1901722)4.30357930
43positive regulation of interleukin-8 secretion (GO:2000484)4.28565858
44atrioventricular valve morphogenesis (GO:0003181)4.20719560
45regulation of ruffle assembly (GO:1900027)4.19924952
46positive regulation of epidermis development (GO:0045684)4.18738497
47regulation of chemokine secretion (GO:0090196)4.12673016
48water homeostasis (GO:0030104)4.09515473
49positive regulation of epidermal cell differentiation (GO:0045606)4.07507070
50skin morphogenesis (GO:0043589)3.98198387
51epidermis development (GO:0008544)3.92687290
52peptide cross-linking (GO:0018149)3.92093910
53regulation of keratinocyte differentiation (GO:0045616)3.81993000
54maturation of SSU-rRNA (GO:0030490)3.73315555
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65010948
56positive regulation of hair follicle development (GO:0051798)3.62772984
57positive regulation of hair cycle (GO:0042635)3.62772984
58regulation of epidermis development (GO:0045682)3.61223717
59intestinal epithelial cell development (GO:0060576)3.60304292
60protein targeting to ER (GO:0045047)3.60192960
61viral life cycle (GO:0019058)3.58843877
62hypotonic response (GO:0006971)3.58540397
63cotranslational protein targeting to membrane (GO:0006613)3.57998901
64cardiac right ventricle morphogenesis (GO:0003215)3.57892244
65detection of other organism (GO:0098543)3.57244862
66prostanoid metabolic process (GO:0006692)3.55519607
67prostaglandin metabolic process (GO:0006693)3.55519607
68translational elongation (GO:0006414)3.54611774
69endodermal cell differentiation (GO:0035987)3.54385902
70negative regulation of epidermis development (GO:0045683)3.50565412
71regulation of interleukin-8 secretion (GO:2000482)3.48710132
72establishment of protein localization to endoplasmic reticulum (GO:0072599)3.48490442
73regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.47176287
74cellular protein complex disassembly (GO:0043624)3.46221205
75positive regulation of odontogenesis (GO:0042482)3.44632204
76ventricular cardiac muscle cell action potential (GO:0086005)3.42764797
77axonemal dynein complex assembly (GO:0070286)3.40557847
78regulation of transforming growth factor beta2 production (GO:0032909)3.40275565
79hair follicle morphogenesis (GO:0031069)3.37334607
80negative regulation of interleukin-2 production (GO:0032703)3.36904585
81negative regulation of interferon-gamma production (GO:0032689)3.36284884
82positive regulation of chemokine secretion (GO:0090197)3.33090954
83protein localization to endoplasmic reticulum (GO:0070972)3.32304659
84negative regulation of chondrocyte differentiation (GO:0032331)3.31567892
85positive regulation of vesicle fusion (GO:0031340)3.30941845
86glomerular visceral epithelial cell development (GO:0072015)3.28831190
87regulation of hair cycle (GO:0042634)3.25683571
88nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.25245185
89mesodermal cell differentiation (GO:0048333)3.25128619
90epithelium development (GO:0060429)3.24542618
91positive regulation of keratinocyte differentiation (GO:0045618)3.23004022
92skin development (GO:0043588)3.18293656
93peptidyl-tyrosine autophosphorylation (GO:0038083)3.17248305
94cell junction assembly (GO:0034329)3.15927123
95long-chain fatty acid biosynthetic process (GO:0042759)3.14509465
96ribosomal small subunit assembly (GO:0000028)3.13115715
97regulation of endothelial cell differentiation (GO:0045601)3.12195515
98regulation of hypersensitivity (GO:0002883)3.11698233
99planar cell polarity pathway involved in neural tube closure (GO:0090179)3.09384749
100protein localization to endosome (GO:0036010)3.08357214
101cell junction organization (GO:0034330)3.07536474
102cellular response to interferon-alpha (GO:0035457)3.07300593
103fatty acid elongation (GO:0030497)3.02630280
104heart valve morphogenesis (GO:0003179)3.01976495
105negative regulation of kidney development (GO:0090185)3.00688240
106phosphatidylinositol acyl-chain remodeling (GO:0036149)3.00495197
107molting cycle process (GO:0022404)3.00043434
108hair cycle process (GO:0022405)3.00043434
109renal system development (GO:0072001)2.99874544
110regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.99181403
111lymphangiogenesis (GO:0001946)2.98968493
112lipoxygenase pathway (GO:0019372)2.98253319
113glomerular epithelial cell development (GO:0072310)2.97859482
114negative regulation of cell fate specification (GO:0009996)2.97424440
115membrane budding (GO:0006900)2.97200994
116renal filtration (GO:0097205)2.96914410
117cellular response to antibiotic (GO:0071236)2.95961508
118regulation of epidermal cell differentiation (GO:0045604)2.94017721
119regulation of heart rate by cardiac conduction (GO:0086091)2.88829372
120cell communication involved in cardiac conduction (GO:0086065)2.88266634
121cyclooxygenase pathway (GO:0019371)2.86810404
122negative regulation of acute inflammatory response (GO:0002674)2.85639016
123regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.83578073
124cell-substrate junction assembly (GO:0007044)2.81579485
125wound healing (GO:0042060)2.77967392
126regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.76728600
127protein complex disassembly (GO:0043241)2.76604891
128linoleic acid metabolic process (GO:0043651)2.76208894
129primary alcohol catabolic process (GO:0034310)2.75840905
130ribosomal large subunit biogenesis (GO:0042273)2.74798362
131phosphatidylserine acyl-chain remodeling (GO:0036150)2.73333124
132positive regulation of interleukin-4 production (GO:0032753)2.73051855
133gland morphogenesis (GO:0022612)2.73027338
134negative regulation of stress fiber assembly (GO:0051497)2.70910355
135detection of bacterium (GO:0016045)2.69893680
136extracellular matrix disassembly (GO:0022617)2.68647321
137protein targeting to membrane (GO:0006612)2.67839570
138negative regulation of keratinocyte proliferation (GO:0010839)2.67679742
139eyelid development in camera-type eye (GO:0061029)2.67062747
140arachidonic acid secretion (GO:0050482)2.66928796
141icosanoid secretion (GO:0032309)2.66928796
142translational initiation (GO:0006413)2.66399632
143cytoskeletal anchoring at plasma membrane (GO:0007016)2.61265756
144cilium or flagellum-dependent cell motility (GO:0001539)2.60083214
145negative regulation of cell fate commitment (GO:0010454)2.59348716
146lymph vessel development (GO:0001945)2.58491504
147intermediate filament cytoskeleton organization (GO:0045104)2.56263987
148cellular copper ion homeostasis (GO:0006878)2.56224381
149positive regulation of endothelial cell differentiation (GO:0045603)2.52927867
150regulation of protein localization to cell surface (GO:2000008)2.52486789
151mitotic G1 DNA damage checkpoint (GO:0031571)2.52141688
152icosanoid biosynthetic process (GO:0046456)2.51686019
153fatty acid derivative biosynthetic process (GO:1901570)2.51686019
154macromolecular complex disassembly (GO:0032984)2.51349833
155prostate gland epithelium morphogenesis (GO:0060740)2.50134185
156chemical homeostasis within a tissue (GO:0048875)2.49861183
157L-serine transport (GO:0015825)2.49142330
158hair follicle development (GO:0001942)2.47941675
159positive regulation of monocyte chemotaxis (GO:0090026)2.47071736
160epithelial cell proliferation (GO:0050673)2.44334338
161mammary gland development (GO:0030879)2.43596758
162apical protein localization (GO:0045176)2.38585305
163morphogenesis of embryonic epithelium (GO:0016331)2.35598372
164neural crest cell development (GO:0014032)2.35322177
165regulation of transforming growth factor beta production (GO:0071634)2.34956247
166genitalia morphogenesis (GO:0035112)2.34617559
167Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.34181667
168regulation of cardioblast differentiation (GO:0051890)2.32888150
169regulation of establishment of planar polarity (GO:0090175)2.31240633
170smooth muscle tissue development (GO:0048745)2.29677758
171desmosome organization (GO:0002934)12.5108896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.43751792
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.14487928
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.86888450
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.78222188
5* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.67542122
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.66180210
7ZNF263_19887448_ChIP-Seq_K562_Human2.63889350
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.61870036
9SOX9_24532713_ChIP-Seq_HFSC_Mouse2.54946277
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.00991886
11* TP63_17297297_ChIP-ChIP_HaCaT_Human14.8843205
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.89095814
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.89095814
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81088848
15ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72663006
16FOXO3_23340844_ChIP-Seq_DLD1_Human1.68887998
17SOX2_20726797_ChIP-Seq_SW620_Human1.65162481
18* CJUN_26792858_Chip-Seq_BT549_Human1.60395003
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57956955
20GATA2_21666600_ChIP-Seq_HMVEC_Human1.48158382
21CDX2_20551321_ChIP-Seq_CACO-2_Human1.36854711
22AR_21572438_ChIP-Seq_LNCaP_Human1.36204202
23TP53_18474530_ChIP-ChIP_U2OS_Human1.31364450
24TCF4_18268006_ChIP-ChIP_LS174T_Human1.29476045
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28542984
26* TP63_23658742_ChIP-Seq_EP156T_Human1.26457770
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25425552
28TP53_20018659_ChIP-ChIP_R1E_Mouse1.24824878
29AHR_22903824_ChIP-Seq_MCF-7_Human1.23862231
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21963360
31RUNX1_27514584_Chip-Seq_MCF-7_Human1.20796669
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19036762
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11581773
34KLF5_25053715_ChIP-Seq_YYC3_Human1.10317385
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08640164
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05483443
37EGR1_19032775_ChIP-ChIP_M12_Human1.05112374
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04937920
39SMAD3_21741376_ChIP-Seq_HESCs_Human1.03520796
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03283650
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.02903383
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02719935
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.00842023
44FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00703377
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99744778
46RXR_22108803_ChIP-Seq_LS180_Human0.96735982
47* TP63_22573176_ChIP-Seq_HFKS_Human0.96689952
48SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95859753
49UBF1/2_26484160_Chip-Seq_HMECs_Human0.95357053
50BCAT_22108803_ChIP-Seq_LS180_Human0.95037677
51PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93266357
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91206089
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90514205
54TBX20_22080862_ChIP-Seq_HEART_Mouse0.90497738
55TBX20_22328084_ChIP-Seq_HEART_Mouse0.90497738
56ESR1_20079471_ChIP-ChIP_T-47D_Human0.90427644
57GATA4_25053715_ChIP-Seq_YYC3_Human0.90407260
58* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89711029
59JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89627652
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89053219
61RACK7_27058665_Chip-Seq_MCF-7_Human0.88929105
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88387035
63BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88120096
64ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85531093
65CLOCK_20551151_ChIP-Seq_293T_Human0.85248049
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85224771
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84960789
68P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84834556
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83416440
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83011758
71ARNT_22903824_ChIP-Seq_MCF-7_Human0.81964666
72EZH2_27294783_Chip-Seq_ESCs_Mouse0.80835280
73JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80266433
74CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80163604
75FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79359977
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78628636
77STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.78372102
78NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77853943
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77853943
80SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.77044088
81* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.76681755
82EP300_21415370_ChIP-Seq_HL-1_Mouse0.76216246
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75002536
84CEBPB_22108803_ChIP-Seq_LS180_Human0.74596576
85PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74550288
86GATA3_24758297_ChIP-Seq_MCF-7_Human0.74524786
87RNF2_18974828_ChIP-Seq_MESCs_Mouse0.74410939
88EZH2_18974828_ChIP-Seq_MESCs_Mouse0.74410939
89BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73805117
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.73529841
91GATA6_25053715_ChIP-Seq_YYC3_Human0.73105372
92* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72608151
93AR_21909140_ChIP-Seq_LNCAP_Human0.71509668
94ATF3_27146783_Chip-Seq_COLON_Human0.71272706
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70691648
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.70573948
97ELK4_26923725_Chip-Seq_MESODERM_Mouse0.69783510
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68515152
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.68381677
100RNF2_27304074_Chip-Seq_ESCs_Mouse0.68029818
101FOXM1_26456572_ChIP-Seq_MCF-7_Human0.67740214
102SOX2_27498859_Chip-Seq_STOMACH_Mouse0.67521700
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.66703601
104TP53_16413492_ChIP-PET_HCT116_Human0.66589579
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.66224795
106JARID2_20075857_ChIP-Seq_MESCs_Mouse0.64692172
107MTF2_20144788_ChIP-Seq_MESCs_Mouse0.64353096
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.64265041
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.63894177
110KDM2B_26808549_Chip-Seq_K562_Human0.63530791
111VDR_22108803_ChIP-Seq_LS180_Human0.63229906
112ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.61319583
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.61111854
114* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.60866887
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.60577953
116* GATA6_21074721_ChIP-Seq_CACO-2_Human0.59424033
117KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.59384126
118KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.59384126
119KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.59384126
120JARID2_20064375_ChIP-Seq_MESCs_Mouse0.59072478
121P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.58922919
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.58530613
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.58395899
124BRD4_25478319_ChIP-Seq_HGPS_Human0.58341420
125TCF4_22108803_ChIP-Seq_LS180_Human0.58277947
126ELK3_25401928_ChIP-Seq_HUVEC_Human0.58108948
127EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.57866030
128GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.57805379
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.57761147
130* RBPJ_21746931_ChIP-Seq_IB4_Human0.57517587
131CTNNB1_20460455_ChIP-Seq_HCT116_Human0.56472358
132PIAS1_25552417_ChIP-Seq_VCAP_Human0.55538068
133FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55388830
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.54511415
135* ETV1_20927104_ChIP-Seq_GIST48_Human0.53149240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.21421390
2MP0004381_abnormal_hair_follicle5.46154466
3MP0003941_abnormal_skin_development5.07390007
4MP0002254_reproductive_system_inflammat4.77408236
5MP0010234_abnormal_vibrissa_follicle4.48087089
6MP0005501_abnormal_skin_physiology3.80426882
7MP0005275_abnormal_skin_tensile3.71499881
8MP0000383_abnormal_hair_follicle3.63284274
9MP0002060_abnormal_skin_morphology3.48798532
10MP0003453_abnormal_keratinocyte_physiol3.35419640
11MP0010678_abnormal_skin_adnexa3.18396110
12MP0001216_abnormal_epidermal_layer3.14407966
13MP0000579_abnormal_nail_morphology2.94278734
14MP0009379_abnormal_foot_pigmentation2.78951975
15MP0000647_abnormal_sebaceous_gland2.73863646
16MP0010771_integument_phenotype2.69537067
17MP0000467_abnormal_esophagus_morphology2.52572453
18MP0002098_abnormal_vibrissa_morphology2.39029006
19MP0000566_synostosis2.36242630
20MP0001851_eye_inflammation2.29039265
21MP0000427_abnormal_hair_cycle2.22307042
22MP0003136_yellow_coat_color2.16931527
23MP0004947_skin_inflammation2.13419155
24MP0003566_abnormal_cell_adhesion2.12468335
25MP0000377_abnormal_hair_follicle2.03921814
26MP0004264_abnormal_extraembryonic_tissu2.00345430
27MP0000762_abnormal_tongue_morphology1.83909198
28MP0006054_spinal_hemorrhage1.78032687
29MP0003724_increased_susceptibility_to1.74630786
30MP0002009_preneoplasia1.74183349
31MP0001346_abnormal_lacrimal_gland1.68097307
32MP0001191_abnormal_skin_condition1.66573124
33MP0003705_abnormal_hypodermis_morpholog1.62484086
34MP0009931_abnormal_skin_appearance1.56409421
35MP0004885_abnormal_endolymph1.54350801
36MP0004185_abnormal_adipocyte_glucose1.52706111
37MP0003828_pulmonary_edema1.52669845
38MP0002877_abnormal_melanocyte_morpholog1.50549390
39MP0000465_gastrointestinal_hemorrhage1.49660641
40MP0002132_abnormal_respiratory_system1.41665575
41MP0001243_abnormal_dermal_layer1.31887376
42MP0000678_abnormal_parathyroid_gland1.29344265
43MP0009780_abnormal_chondrocyte_physiolo1.21970057
44MP0005451_abnormal_body_composition1.19434078
45MP0008789_abnormal_olfactory_epithelium1.18916831
46MP0000367_abnormal_coat/_hair1.17578431
47MP0005023_abnormal_wound_healing1.15235787
48MP0001879_abnormal_lymphatic_vessel1.15168387
49MP0005187_abnormal_penis_morphology1.14045184
50MP0008260_abnormal_autophagy1.11527118
51MP0004272_abnormal_basement_membrane1.10789681
52MP0010352_gastrointestinal_tract_polyps1.09193604
53MP0001340_abnormal_eyelid_morphology1.04931090
54MP0010030_abnormal_orbit_morphology1.03678500
55MP0004782_abnormal_surfactant_physiolog1.00741209
56MP0003315_abnormal_perineum_morphology0.93324936
57MP0005257_abnormal_intraocular_pressure0.91569463
58MP0002277_abnormal_respiratory_mucosa0.84479843
59MP0005499_abnormal_olfactory_system0.84207618
60MP0005394_taste/olfaction_phenotype0.84207618
61MP0005248_abnormal_Harderian_gland0.79689827
62MP0008438_abnormal_cutaneous_collagen0.79487442
63MP0005377_hearing/vestibular/ear_phenot0.78781335
64MP0003878_abnormal_ear_physiology0.78781335
65MP0005076_abnormal_cell_differentiation0.76011701
66MP0008004_abnormal_stomach_pH0.74626147
67MP0005409_darkened_coat_color0.74277909
68MP0000627_abnormal_mammary_gland0.73828241
69MP0001849_ear_inflammation0.72362156
70MP0005503_abnormal_tendon_morphology0.70856083
71MP0003638_abnormal_response/metabolism_0.69648539
72MP0002163_abnormal_gland_morphology0.67850563
73MP0000537_abnormal_urethra_morphology0.67332605
74MP0002166_altered_tumor_susceptibility0.64350259
75MP0001299_abnormal_eye_distance/0.64236696
76MP0002006_tumorigenesis0.63754474
77MP0001784_abnormal_fluid_regulation0.63742212
78MP0005508_abnormal_skeleton_morphology0.63297608
79MP0003011_delayed_dark_adaptation0.61560126
80MP0010368_abnormal_lymphatic_system0.60092567
81MP0009053_abnormal_anal_canal0.60051352
82MP0002896_abnormal_bone_mineralization0.58238627
83MP0003385_abnormal_body_wall0.56976785
84MP0003183_abnormal_peptide_metabolism0.55922163
85MP0005167_abnormal_blood-brain_barrier0.53457257
86MP0002148_abnormal_hypersensitivity_rea0.53149786
87MP0003300_gastrointestinal_ulcer0.51206647
88MP0000858_altered_metastatic_potential0.50314678
89MP0005075_abnormal_melanosome_morpholog0.50075395
90MP0009250_abnormal_appendicular_skeleto0.49627458
91MP0001188_hyperpigmentation0.48419636
92MP0002234_abnormal_pharynx_morphology0.48373936
93MP0001958_emphysema0.47821139
94MP0005623_abnormal_meninges_morphology0.47316891
95MP0004883_abnormal_blood_vessel0.47063521
96MP0003755_abnormal_palate_morphology0.46323155
97MP0010155_abnormal_intestine_physiology0.46298714
98MP0000372_irregular_coat_pigmentation0.46147900
99MP0002089_abnormal_postnatal_growth/wei0.45860531
100MP0002177_abnormal_outer_ear0.44854403
101MP0002111_abnormal_tail_morphology0.44065544
102MP0005360_urolithiasis0.44058685
103MP0003191_abnormal_cellular_cholesterol0.43428385
104MP0005390_skeleton_phenotype0.43326724
105MP0002282_abnormal_trachea_morphology0.42788495
106MP0002133_abnormal_respiratory_system0.42423902
107MP0005388_respiratory_system_phenotype0.42423902
108MP0003436_decreased_susceptibility_to0.42355394
109MP0005193_abnormal_anterior_eye0.41391060
110MP0004019_abnormal_vitamin_homeostasis0.41113328
111MP0003763_abnormal_thymus_physiology0.40942537
112MP0003950_abnormal_plasma_membrane0.40711820
113MP0000767_abnormal_smooth_muscle0.40451606
114MP0001765_abnormal_ion_homeostasis0.40370690
115MP0002295_abnormal_pulmonary_circulatio0.38949027
116MP0000432_abnormal_head_morphology0.38946251
117MP0005408_hypopigmentation0.38527935
118MP0002233_abnormal_nose_morphology0.38469779
119MP0006138_congestive_heart_failure0.38355624
120MP0003329_amyloid_beta_deposits0.38230935
121MP0009384_cardiac_valve_regurgitation0.38139553
122MP0003091_abnormal_cell_migration0.37811356
123MP0005164_abnormal_response_to0.37560761
124MP0005197_abnormal_uvea_morphology0.37096544
125MP0000462_abnormal_digestive_system0.36681161
126MP0004484_altered_response_of0.36254589
127MP0000613_abnormal_salivary_gland0.35140351
128MP0003448_altered_tumor_morphology0.35043248
129MP0001533_abnormal_skeleton_physiology0.35016428
130MP0000538_abnormal_urinary_bladder0.34610880
131MP0005165_increased_susceptibility_to0.34590393
132MP0003045_fibrosis0.34091029
133MP0002095_abnormal_skin_pigmentation0.33908933
134MP0002697_abnormal_eye_size0.27938581
135MP0002168_other_aberrant_phenotype0.26885685

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)6.62787241
2Hypotrichosis (HP:0001006)6.51045103
3Plantar hyperkeratosis (HP:0007556)6.13778860
4Milia (HP:0001056)5.40335063
5Parakeratosis (HP:0001036)5.34516990
6Fragile nails (HP:0001808)5.27663663
7Palmoplantar hyperkeratosis (HP:0000972)5.17056292
8Woolly hair (HP:0002224)4.87295691
9Palmar hyperkeratosis (HP:0010765)4.86587309
10Onycholysis (HP:0001806)4.85236352
11Thick nail (HP:0001805)4.76667253
12Abnormality of the axillary hair (HP:0100134)4.66442067
13Abnormality of secondary sexual hair (HP:0009888)4.66442067
14Right ventricular cardiomyopathy (HP:0011663)4.65519774
15Congenital ichthyosiform erythroderma (HP:0007431)4.51834069
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.35175288
17Ectropion (HP:0000656)4.21783485
18Oral leukoplakia (HP:0002745)4.19102030
19Abnormal hair laboratory examination (HP:0003328)4.02982147
20Nail dystrophy (HP:0008404)3.99099933
21Erythema (HP:0010783)3.95950965
22Abnormal hemoglobin (HP:0011902)3.95582390
23Abnormality of nail color (HP:0100643)3.90655008
24Abnormal blistering of the skin (HP:0008066)3.81255215
25Increased IgE level (HP:0003212)3.65565688
26Natal tooth (HP:0000695)3.64117422
27Aplasia cutis congenita (HP:0001057)3.61893188
28Atrophic scars (HP:0001075)3.58807128
29Alopecia of scalp (HP:0002293)3.57963512
30Distal lower limb muscle weakness (HP:0009053)3.57961055
31Abnormality of cells of the erythroid lineage (HP:0012130)3.53115269
32Selective tooth agenesis (HP:0001592)3.40693527
33Absent eyelashes (HP:0000561)3.37313555
34Reticulocytopenia (HP:0001896)3.28018314
35Hypohidrosis (HP:0000966)3.26597040
36Sparse eyelashes (HP:0000653)3.22194549
37Conical tooth (HP:0000698)3.18230119
38Advanced eruption of teeth (HP:0006288)3.13855878
39Concave nail (HP:0001598)3.13015417
40Ridged nail (HP:0001807)3.11204066
41Hyporeflexia of lower limbs (HP:0002600)3.10902607
42Erythroderma (HP:0001019)3.10763083
43Popliteal pterygium (HP:0009756)3.05193786
44Conjunctival hamartoma (HP:0100780)2.98905854
45Pili torti (HP:0003777)2.97917680
46Abnormal number of erythroid precursors (HP:0012131)2.93178729
47Corneal erosion (HP:0200020)2.92777061
48Oligodontia (HP:0000677)2.90692371
49Sparse scalp hair (HP:0002209)2.88716043
50Anhidrosis (HP:0000970)2.85084499
51Gangrene (HP:0100758)2.83529172
52Dry hair (HP:0011359)2.76536385
53Increased connective tissue (HP:0009025)2.75404261
54Premature skin wrinkling (HP:0100678)2.71127996
55Calcaneovalgus deformity (HP:0001848)2.69784102
56Follicular hyperkeratosis (HP:0007502)2.68627905
57Pruritus (HP:0000989)2.66382006
58Abnormality of placental membranes (HP:0011409)2.62188242
59Amniotic constriction ring (HP:0009775)2.62188242
60Deformed tarsal bones (HP:0008119)2.60833594
61Ventricular tachycardia (HP:0004756)2.59870910
62Anonychia (HP:0001798)2.59544985
63Fragile skin (HP:0001030)2.56765402
64Pterygium (HP:0001059)2.54625499
65Acanthosis nigricans (HP:0000956)2.53731139
66Palmoplantar keratoderma (HP:0000982)2.53059681
67Absent eyebrow (HP:0002223)2.52184064
68Congenital, generalized hypertrichosis (HP:0004540)2.48808390
69Abnormality of the salivary glands (HP:0010286)2.48500766
70Absent hair (HP:0002298)2.45690351
71Aplasia involving bones of the upper limbs (HP:0009823)2.45453336
72Aplasia of the phalanges of the hand (HP:0009802)2.45453336
73Aplasia involving bones of the extremities (HP:0009825)2.45453336
74Septate vagina (HP:0001153)2.39003137
75Hypodontia (HP:0000668)2.38171380
76Carious teeth (HP:0000670)2.36040548
77Hyperhidrosis (HP:0000975)2.29411272
78Abnormality of permanent molar morphology (HP:0011071)2.18870380
79Abnormality of the dental root (HP:0006486)2.18870380
80Taurodontia (HP:0000679)2.18870380
81Areflexia of lower limbs (HP:0002522)2.15811524
82Ankyloglossia (HP:0010296)2.15561851
83Mesangial abnormality (HP:0001966)2.13778295
84Curly hair (HP:0002212)2.12494985
85Macrocytic anemia (HP:0001972)2.11435131
86Myopathic facies (HP:0002058)2.09920002
87Xerostomia (HP:0000217)2.09391097
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08178633
89Hypoplastic labia majora (HP:0000059)2.05083513
90Abnormality of molar (HP:0011077)2.04785129
91Abnormality of molar morphology (HP:0011070)2.04785129
92Laryngomalacia (HP:0001601)2.03694596
93Stenosis of the external auditory canal (HP:0000402)2.03362879
94Hypoplastic nipples (HP:0002557)2.00652433
95Ulnar claw (HP:0001178)2.00533413
96Autoimmune hemolytic anemia (HP:0001890)1.98499859
97Abnormality of the fingernails (HP:0001231)1.97177754
98Dehydration (HP:0001944)1.93962053
99Facial diplegia (HP:0001349)1.93250932
100Split foot (HP:0001839)1.93017482
101Hypoplasia of dental enamel (HP:0006297)1.92798026
102Abnormality of the dental pulp (HP:0006479)1.91753033
103Abnormality of the phalanges of the 2nd finger (HP:0009541)1.91202483
104Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.90838886
105Abnormality of the neuromuscular junction (HP:0003398)1.89859008
106Fatigable weakness (HP:0003473)1.89859008
107Blepharitis (HP:0000498)1.87199146
108Type I diabetes mellitus (HP:0100651)1.86262952
109Neonatal respiratory distress (HP:0002643)1.83927811
110Abnormality of the 2nd finger (HP:0004100)1.83473614
111Abnormality of the labia majora (HP:0012881)1.83426748
112Corneal dystrophy (HP:0001131)1.82552464
113Abnormality of hair growth rate (HP:0011363)1.81884286
114Slow-growing hair (HP:0002217)1.81884286
115Skin ulcer (HP:0200042)1.81621301
116Autoamputation (HP:0001218)1.80629183
117Breast hypoplasia (HP:0003187)1.80305924
118Labial hypoplasia (HP:0000066)1.80240514
119Amelogenesis imperfecta (HP:0000705)1.77135349
120Segmental peripheral demyelination/remyelination (HP:0003481)1.74716626
121Pallor (HP:0000980)1.72712867
122Dry skin (HP:0000958)1.72615893
123Skin pits (HP:0100276)1.70878871
124Esophageal atresia (HP:0002032)1.66871647
125Distal lower limb amyotrophy (HP:0008944)1.66280328
126Abnormal respiratory motile cilium physiology (HP:0012261)1.66048553
127Abnormality of the fetal cardiovascular system (HP:0010948)1.65603246
128Abnormal umbilical cord blood vessels (HP:0011403)1.65603246
129Single umbilical artery (HP:0001195)1.65603246
130Abnormality of the gastric mucosa (HP:0004295)1.64495724
131Recurrent corneal erosions (HP:0000495)1.64414135
132Multifactorial inheritance (HP:0001426)1.64332781
133Hypoplastic female external genitalia (HP:0012815)1.63757929
134Furrowed tongue (HP:0000221)1.63399921
135Absent hand (HP:0004050)1.62963741
136Chronic bronchitis (HP:0004469)1.62360784
137Abnormality of oral frenula (HP:0000190)1.62189798
138Nasolacrimal duct obstruction (HP:0000579)1.62009443
139Polygenic inheritance (HP:0010982)1.60774203
140Abnormality of the calcaneus (HP:0008364)1.60568678
141Abnormal respiratory epithelium morphology (HP:0012253)1.60484350
142Abnormal respiratory motile cilium morphology (HP:0005938)1.60484350
143Pustule (HP:0200039)1.58750752
144Rhinitis (HP:0012384)1.58117874
145Abnormality of the lacrimal duct (HP:0011481)1.55937032
146Abnormal ciliary motility (HP:0012262)1.54238665
147Depressed nasal tip (HP:0000437)1.51148412
148Dynein arm defect of respiratory motile cilia (HP:0012255)1.49825630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.00800929
2MAPKAPK34.24061813
3FER4.14005467
4MST1R4.00491526
5ARAF3.86253081
6MAP3K33.50576503
7MST42.96182026
8PIM22.92495796
9NTRK12.72219880
10TRPM72.61741180
11MAP3K142.14444863
12MAPKAPK52.09201544
13RIPK12.08023937
14RPS6KB22.07787688
15TGFBR22.01501336
16AKT32.01248452
17ERBB32.00259678
18STK241.92246780
19MAP3K21.90303835
20MET1.84297363
21MAP3K121.79072097
22MAP3K61.67633674
23EPHA21.66245244
24EPHB21.58337962
25PTK61.56664383
26KSR21.56621953
27TGFBR11.52906735
28MAPK151.48536267
29PDGFRA1.40426604
30MAP3K111.36110692
31LRRK21.32233217
32EEF2K1.31873838
33GRK11.31784464
34FGFR21.30561724
35KDR1.23565927
36LATS11.21777510
37TESK11.20989972
38MAP2K61.16130828
39BMPR21.12511349
40STK101.10570446
41FGFR41.09961005
42MAP3K91.08476557
43PAK41.06788966
44PDK21.04974967
45MAP2K21.04544501
46FLT31.02491226
47FRK1.01173064
48LIMK11.00936133
49SMG10.97845221
50IKBKE0.97335497
51MAPK120.96650428
52RAF10.96462876
53ERBB20.95274427
54CDK60.93943997
55CDK120.93629670
56IKBKB0.88526325
57FGFR30.88303349
58TRIB30.87845462
59LATS20.86861626
60NTRK20.82317659
61LMTK20.82007281
62BRAF0.81413828
63ERN10.80946944
64ROCK20.78585624
65MAPKAPK20.77092503
66RET0.76693714
67FGFR10.76446629
68PRKCI0.76070820
69TSSK60.75199862
70PDGFRB0.75147696
71PRKD10.74879335
72TBK10.73833867
73MAP2K10.73415091
74PIK3CG0.72611476
75BMPR1B0.72010103
76MATK0.70932567
77EIF2AK20.69652997
78MAP3K10.69450444
79DYRK1B0.69234192
80EPHA30.69052996
81STK380.68614441
82JAK10.64558575
83PBK0.64138311
84TYK20.62551221
85TTN0.62222790
86CDC42BPA0.60276717
87RPS6KB10.59563764
88STK30.58833336
89MAP3K130.58523859
90CSF1R0.56828031
91MAP3K70.56619971
92GRK70.55442604
93PTK20.53739451
94MAPK70.51813779
95MAPK40.51260199
96CHUK0.50916659
97CDK30.49701802
98GSK3A0.45433587
99EPHB10.43472741
100ICK0.42552762
101CSK0.42033851
102MAP3K50.41361242
103GRK60.41187475
104NEK60.37208911
105MAP2K40.36322835
106PRKCE0.35024963
107RPS6KA20.34154566
108TEC0.33947463
109TAOK10.33513282
110ITK0.32913921
111ILK0.32656418
112PRKD20.32137095
113MYLK0.31475157
114MOS0.31334450
115STK110.30857759
116MTOR0.30199123
117YES10.30132072
118ABL10.29632744
119JAK30.28455920
120CDK190.28248008
121RPS6KA10.28204331
122CSNK1A1L0.27822733
123ROCK10.27476719
124CAMK1G0.27012059
125BMX0.24920465
126TYRO30.24778462
127WNK10.24246653
128FYN0.23987852
129IGF1R0.23736596
130INSR0.22810001
131MAPK110.22682033
132DMPK0.22323154
133SIK10.20874143
134EGFR0.20854013
135STK38L0.20722157
136PRKCD0.20677013
137SRC0.20310168
138RPS6KL10.20304377
139RPS6KC10.20304377
140RPS6KA40.19982425
141CASK0.19838685
142ADRBK10.19772003
143BCR0.19754655
144ERBB40.19291218
145SIK30.18872050

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.05973203
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.60702461
3Sphingolipid metabolism_Homo sapiens_hsa006002.84356019
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.76546455
5Linoleic acid metabolism_Homo sapiens_hsa005912.69298978
6Arachidonic acid metabolism_Homo sapiens_hsa005902.51237452
7Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.32946496
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14967764
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.78680385
10ECM-receptor interaction_Homo sapiens_hsa045121.71673324
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68230063
12Basal cell carcinoma_Homo sapiens_hsa052171.65194203
13Phenylalanine metabolism_Homo sapiens_hsa003601.60734486
14Ether lipid metabolism_Homo sapiens_hsa005651.54460635
15Steroid biosynthesis_Homo sapiens_hsa001001.52403428
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51652885
17Adherens junction_Homo sapiens_hsa045201.50417252
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49365354
19Histidine metabolism_Homo sapiens_hsa003401.48045554
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.45355798
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43917632
22Fatty acid elongation_Homo sapiens_hsa000621.43148415
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.35224292
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.34912928
25Tight junction_Homo sapiens_hsa045301.30981793
26Axon guidance_Homo sapiens_hsa043601.29240591
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28324586
28Proteoglycans in cancer_Homo sapiens_hsa052051.26759024
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23395438
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22874497
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20932419
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19676708
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18546993
34VEGF signaling pathway_Homo sapiens_hsa043701.18370462
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.17092370
36Chemical carcinogenesis_Homo sapiens_hsa052041.14374431
37Amoebiasis_Homo sapiens_hsa051461.14339492
38Glioma_Homo sapiens_hsa052141.10531042
39Toxoplasmosis_Homo sapiens_hsa051451.09278200
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08891761
41Retinol metabolism_Homo sapiens_hsa008301.07123337
42Hippo signaling pathway_Homo sapiens_hsa043901.07119045
43Pancreatic cancer_Homo sapiens_hsa052121.06963029
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05845516
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.05449291
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98506941
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98368206
48Platelet activation_Homo sapiens_hsa046110.97841521
49TNF signaling pathway_Homo sapiens_hsa046680.96832855
50Endometrial cancer_Homo sapiens_hsa052130.93710428
51Pertussis_Homo sapiens_hsa051330.93334363
52Acute myeloid leukemia_Homo sapiens_hsa052210.91843371
53Caffeine metabolism_Homo sapiens_hsa002320.91742776
54Rap1 signaling pathway_Homo sapiens_hsa040150.90746832
55Hedgehog signaling pathway_Homo sapiens_hsa043400.90576241
56Thyroid cancer_Homo sapiens_hsa052160.90541349
57Melanogenesis_Homo sapiens_hsa049160.89875236
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.88062985
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.87574178
60Hematopoietic cell lineage_Homo sapiens_hsa046400.84380729
61Bladder cancer_Homo sapiens_hsa052190.83408598
62Staphylococcus aureus infection_Homo sapiens_hsa051500.83231534
63Serotonergic synapse_Homo sapiens_hsa047260.82719908
64Malaria_Homo sapiens_hsa051440.82000207
65Salmonella infection_Homo sapiens_hsa051320.81947061
66Hepatitis C_Homo sapiens_hsa051600.81873205
67TGF-beta signaling pathway_Homo sapiens_hsa043500.81669290
68* Pancreatic secretion_Homo sapiens_hsa049720.81424762
69GnRH signaling pathway_Homo sapiens_hsa049120.81329140
70Chronic myeloid leukemia_Homo sapiens_hsa052200.78604840
71Ras signaling pathway_Homo sapiens_hsa040140.77845916
72Leishmaniasis_Homo sapiens_hsa051400.77756073
73Choline metabolism in cancer_Homo sapiens_hsa052310.76730982
74Phototransduction_Homo sapiens_hsa047440.76697982
75p53 signaling pathway_Homo sapiens_hsa041150.76063442
76MicroRNAs in cancer_Homo sapiens_hsa052060.75999910
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75491990
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.73468766
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72113879
80Renal cell carcinoma_Homo sapiens_hsa052110.71203143
81Protein digestion and absorption_Homo sapiens_hsa049740.70428347
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.70002228
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68941703
84Inositol phosphate metabolism_Homo sapiens_hsa005620.68309541
85Tyrosine metabolism_Homo sapiens_hsa003500.67321449
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66916936
87Complement and coagulation cascades_Homo sapiens_hsa046100.66837126
88Long-term depression_Homo sapiens_hsa047300.65913936
89Focal adhesion_Homo sapiens_hsa045100.65406984
90Insulin signaling pathway_Homo sapiens_hsa049100.65128550
91Ovarian steroidogenesis_Homo sapiens_hsa049130.64606113
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64157919
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63985899
94Notch signaling pathway_Homo sapiens_hsa043300.63764629
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.62922421
96Circadian rhythm_Homo sapiens_hsa047100.62041883
97Legionellosis_Homo sapiens_hsa051340.61603549
98Prion diseases_Homo sapiens_hsa050200.59752500
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59118342
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.59092934
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58435630
102Small cell lung cancer_Homo sapiens_hsa052220.57981550
103Melanoma_Homo sapiens_hsa052180.57905064
104Influenza A_Homo sapiens_hsa051640.56999080
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56575497
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55718430
107Endocytosis_Homo sapiens_hsa041440.54047558
108Vitamin digestion and absorption_Homo sapiens_hsa049770.53984592
109Osteoclast differentiation_Homo sapiens_hsa043800.53932073
110Salivary secretion_Homo sapiens_hsa049700.53794238
111Lysosome_Homo sapiens_hsa041420.53414377
112Dorso-ventral axis formation_Homo sapiens_hsa043200.52777302
113* Renin secretion_Homo sapiens_hsa049240.52737404
114Non-small cell lung cancer_Homo sapiens_hsa052230.50983828
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50889975
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50838647
117Fat digestion and absorption_Homo sapiens_hsa049750.50783439
118Prostate cancer_Homo sapiens_hsa052150.49867580
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49533220
120Dilated cardiomyopathy_Homo sapiens_hsa054140.49512176
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47602807
122Fatty acid biosynthesis_Homo sapiens_hsa000610.46923363
123Mineral absorption_Homo sapiens_hsa049780.45870284
124Rheumatoid arthritis_Homo sapiens_hsa053230.45665602
125Gastric acid secretion_Homo sapiens_hsa049710.44890854
126Insulin resistance_Homo sapiens_hsa049310.44563352
127ABC transporters_Homo sapiens_hsa020100.44479444
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.44388082
129Wnt signaling pathway_Homo sapiens_hsa043100.44131308
130Glycerolipid metabolism_Homo sapiens_hsa005610.44114935
131Pathways in cancer_Homo sapiens_hsa052000.44064637
132Estrogen signaling pathway_Homo sapiens_hsa049150.43923326
133Shigellosis_Homo sapiens_hsa051310.43623436
134ErbB signaling pathway_Homo sapiens_hsa040120.43048124
135Apoptosis_Homo sapiens_hsa042100.42828718
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40196262
137Cocaine addiction_Homo sapiens_hsa050300.40094486
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37558844

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