CLCA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of respiratory burst (GO:0060267)7.83150339
2intestinal absorption (GO:0050892)6.31539945
3bundle of His cell to Purkinje myocyte communication (GO:0086069)6.27724646
4regulation of guanylate cyclase activity (GO:0031282)6.16863993
5sulfate transmembrane transport (GO:1902358)6.13852511
6glomerular filtration (GO:0003094)6.13083392
7desmosome organization (GO:0002934)5.98974878
8oligosaccharide biosynthetic process (GO:0009312)5.89545365
9regulation of respiratory burst (GO:0060263)5.68328065
10maintenance of gastrointestinal epithelium (GO:0030277)5.67367053
11renal filtration (GO:0097205)5.66500831
12cellular glucuronidation (GO:0052695)5.32036590
13uronic acid metabolic process (GO:0006063)5.11731190
14glucuronate metabolic process (GO:0019585)5.11731190
15sulfate transport (GO:0008272)5.02442732
16O-glycan processing (GO:0016266)4.95516167
17bicarbonate transport (GO:0015701)4.93696944
18renal system process involved in regulation of blood volume (GO:0001977)4.89907188
19calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.78163488
20negative regulation of myotube differentiation (GO:0010832)4.73750864
21flavonoid metabolic process (GO:0009812)4.57159866
22positive regulation of pseudopodium assembly (GO:0031274)4.57057602
23positive regulation of fatty acid beta-oxidation (GO:0032000)4.56705971
24sperm capacitation (GO:0048240)4.55803468
25regulation of vitamin metabolic process (GO:0030656)4.46548586
26regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.28209421
27ethanol oxidation (GO:0006069)4.25384920
28glucocorticoid biosynthetic process (GO:0006704)4.22504545
29epithelial structure maintenance (GO:0010669)4.18079012
30receptor guanylyl cyclase signaling pathway (GO:0007168)4.16961816
31bile acid and bile salt transport (GO:0015721)4.14353045
32antibacterial humoral response (GO:0019731)4.12160759
33positive regulation of guanylate cyclase activity (GO:0031284)4.10557954
34regulation of pseudopodium assembly (GO:0031272)4.09590528
35antimicrobial humoral response (GO:0019730)4.08738963
36regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.04059393
37endocrine process (GO:0050886)4.04059393
38regulation of systemic arterial blood pressure by hormone (GO:0001990)4.04059393
39regulation of cellular extravasation (GO:0002691)3.99341483
40transcytosis (GO:0045056)3.95791768
41regulation of intracellular pH (GO:0051453)3.81160061
42nucleoside diphosphate biosynthetic process (GO:0009133)3.81016298
43GDP-mannose metabolic process (GO:0019673)3.78035518
44regulation of cGMP biosynthetic process (GO:0030826)3.70474912
45cGMP-mediated signaling (GO:0019934)3.69947697
46digestive system process (GO:0022600)3.61734443
47positive regulation of Cdc42 GTPase activity (GO:0043089)3.60480233
48fucosylation (GO:0036065)3.60276071
49sulfur amino acid catabolic process (GO:0000098)3.59293769
50intestinal epithelial cell development (GO:0060576)3.58662745
51cellular response to pH (GO:0071467)3.53108543
52regulation of systemic arterial blood pressure (GO:0003073)3.51370644
53complement activation, classical pathway (GO:0006958)3.50711645
54nucleotide-sugar biosynthetic process (GO:0009226)3.48403302
55regulation of cellular pH (GO:0030641)3.47403696
56regulation of viral release from host cell (GO:1902186)3.45597937
57renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.43867767
58multicellular organismal water homeostasis (GO:0050891)3.43533635
59positive regulation of fatty acid oxidation (GO:0046321)3.43212290
60thrombin receptor signaling pathway (GO:0070493)3.42567849
61pyrimidine-containing compound transmembrane transport (GO:0072531)3.41755755
62ethanol metabolic process (GO:0006067)3.38606028
63regulation of cholesterol homeostasis (GO:2000188)3.38240360
64intermediate filament organization (GO:0045109)3.37880567
65antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.35203858
66one-carbon metabolic process (GO:0006730)3.32649180
67eosinophil chemotaxis (GO:0048245)3.30169218
683-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.27579111
69purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.27579111
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.24255062
71sodium ion homeostasis (GO:0055078)3.23245100
72labyrinthine layer development (GO:0060711)3.19900077
73regulation of pH (GO:0006885)3.15931462
74positive regulation of synaptic transmission, GABAergic (GO:0032230)3.15863492
75angiotensin maturation (GO:0002003)3.15815995
76positive regulation of systemic arterial blood pressure (GO:0003084)3.11947792
77actin filament depolymerization (GO:0030042)3.09619153
78UDP-N-acetylglucosamine metabolic process (GO:0006047)3.09594134
79ventricular cardiac muscle cell action potential (GO:0086005)3.04706217
80negative regulation of keratinocyte proliferation (GO:0010839)3.03333139
81regulation of cGMP metabolic process (GO:0030823)3.01767625
82sulfur compound transport (GO:0072348)3.00687210
83protein O-linked glycosylation (GO:0006493)2.99669053
84regulation of water loss via skin (GO:0033561)2.98135123
85gap junction assembly (GO:0016264)2.96585016
86phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.96496200
87monovalent inorganic cation homeostasis (GO:0055067)2.94395614
88excretion (GO:0007588)2.93924469
89negative regulation of leukocyte chemotaxis (GO:0002689)2.93322679
90eosinophil migration (GO:0072677)2.92894616
91regulation of fatty acid beta-oxidation (GO:0031998)2.92647421
92response to acidic pH (GO:0010447)2.91096664
93phosphatidylserine acyl-chain remodeling (GO:0036150)2.89548355
94NADH metabolic process (GO:0006734)2.88981975
95antigen processing and presentation of endogenous antigen (GO:0019883)2.87730671
96retina homeostasis (GO:0001895)2.87380852
97auditory receptor cell differentiation (GO:0042491)2.86440570
98citrulline biosynthetic process (GO:0019240)2.84081967
99arginine catabolic process (GO:0006527)2.83479259
100citrulline metabolic process (GO:0000052)2.82401176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.73969497
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.53899486
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.24137836
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.22504026
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.92496903
6SOX2_20726797_ChIP-Seq_SW620_Human2.84997360
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.70484613
8CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.65578433
9GATA6_25053715_ChIP-Seq_YYC3_Human2.57141229
10GATA4_25053715_ChIP-Seq_YYC3_Human2.55478125
11FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.42781596
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38680139
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.35103390
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.34445871
15* FOXO3_23340844_ChIP-Seq_DLD1_Human2.28493827
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.27324013
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.25630346
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.10495741
19PPARA_22158963_ChIP-Seq_LIVER_Mouse1.93914032
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93684715
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.88219849
22KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.87414338
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86006812
24RXR_22158963_ChIP-Seq_LIVER_Mouse1.85989223
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84365280
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.82473225
27RACK7_27058665_Chip-Seq_MCF-7_Human1.79324819
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79130326
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.74550600
30* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.74199045
31* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.71665989
32KLF5_25053715_ChIP-Seq_YYC3_Human1.66755350
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.65308121
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.59849780
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58241893
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.57219059
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54674100
38LXR_22158963_ChIP-Seq_LIVER_Mouse1.53387580
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.51316454
40PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.47636782
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.47573060
42BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.42870236
43FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.42527194
44LXR_22292898_ChIP-Seq_THP-1_Human1.42339740
45AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.39864515
46NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35773379
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26056472
48CLOCK_20551151_ChIP-Seq_293T_Human1.24950132
49ZNF263_19887448_ChIP-Seq_K562_Human1.23618016
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20695487
51CDX2_22108803_ChIP-Seq_LS180_Human1.18857748
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17494297
53FOXA1_25552417_ChIP-Seq_VCAP_Human1.16298741
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15070236
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14836232
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14836232
57GATA3_24758297_ChIP-Seq_MCF-7_Human1.11501910
58* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10068013
59* DROSHA_22980978_ChIP-Seq_HELA_Human1.09877494
60* CEBPB_22108803_ChIP-Seq_LS180_Human1.08970762
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06920785
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05644400
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05153823
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04739400
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01762490
66TP63_22573176_ChIP-Seq_HFKS_Human0.98847561
67GATA1_19941826_ChIP-Seq_K562_Human0.98412285
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98317963
69* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96567931
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95144426
71SA1_27219007_Chip-Seq_Bcells_Human0.94228047
72AR_21909140_ChIP-Seq_LNCAP_Human0.93048139
73ERG_21242973_ChIP-ChIP_JURKAT_Human0.92129197
74GATA2_19941826_ChIP-Seq_K562_Human0.91070036
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90207449
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89277558
77CREB1_26743006_Chip-Seq_LNCaP_Human0.87103558
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85503250
79NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84247678
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84081299
81* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83733841
82ESR1_20079471_ChIP-ChIP_T-47D_Human0.83200714
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.82900090
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81868730
85TET1_21451524_ChIP-Seq_MESCs_Mouse0.79937220
86FOXA2_19822575_ChIP-Seq_HepG2_Human0.79459334
87SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79189918
88ELK3_25401928_ChIP-Seq_HUVEC_Human0.77984279
89EGR1_19032775_ChIP-ChIP_M12_Human0.77409796
90STAT1_20625510_ChIP-Seq_HELA_Human0.77171990
91P300_27058665_Chip-Seq_ZR-75-30cells_Human0.77089180
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75736568
93* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75365877
94HNF4A_19822575_ChIP-Seq_HepG2_Human0.75209629
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75002826
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74804568
97CTCF_27219007_Chip-Seq_Bcells_Human0.74670429
98ATF3_27146783_Chip-Seq_COLON_Human0.73372744
99RXR_22108803_ChIP-Seq_LS180_Human0.71760376
100BCL6_27268052_Chip-Seq_Bcells_Human0.71614250

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.68543362
2MP0002139_abnormal_hepatobiliary_system5.50486159
3MP0004043_abnormal_pH_regulation4.41302305
4MP0003866_abnormal_defecation3.63025427
5MP0010352_gastrointestinal_tract_polyps3.41186572
6MP0010155_abnormal_intestine_physiology3.00267214
7MP0004264_abnormal_extraembryonic_tissu2.96608548
8MP0002796_impaired_skin_barrier2.94843503
9MP0009379_abnormal_foot_pigmentation2.69768400
10MP0001663_abnormal_digestive_system2.64894732
11MP0005085_abnormal_gallbladder_physiolo2.60229858
12MP0001664_abnormal_digestion2.50594721
13MP0000477_abnormal_intestine_morphology2.40223123
14MP0001873_stomach_inflammation2.38235532
15MP0000490_abnormal_crypts_of2.31401135
16MP0001765_abnormal_ion_homeostasis2.27517302
17MP0005381_digestive/alimentary_phenotyp2.25196487
18MP0000465_gastrointestinal_hemorrhage2.21476098
19MP0003868_abnormal_feces_composition2.09722346
20MP0004782_abnormal_surfactant_physiolog2.06125668
21MP0001666_abnormal_nutrient_absorption1.99069925
22MP0005365_abnormal_bile_salt1.98349127
23MP0004147_increased_porphyrin_level1.86808262
24MP0005360_urolithiasis1.81401201
25MP0002138_abnormal_hepatobiliary_system1.79652648
26MP0005166_decreased_susceptibility_to1.77259307
27MP0000566_synostosis1.75056355
28MP0000467_abnormal_esophagus_morphology1.74588045
29MP0002876_abnormal_thyroid_physiology1.73511069
30MP0005501_abnormal_skin_physiology1.70601729
31MP0003724_increased_susceptibility_to1.65010885
32MP0002098_abnormal_vibrissa_morphology1.62835732
33MP0004858_abnormal_nervous_system1.60058488
34MP0005636_abnormal_mineral_homeostasis1.59088256
35MP0005409_darkened_coat_color1.57487107
36MP0000678_abnormal_parathyroid_gland1.53029578
37MP0003183_abnormal_peptide_metabolism1.51232547
38MP0002009_preneoplasia1.49780540
39MP0010678_abnormal_skin_adnexa1.40208366
40MP0003453_abnormal_keratinocyte_physiol1.32883043
41MP0003303_peritoneal_inflammation1.32207887
42MP0001216_abnormal_epidermal_layer1.30470191
43MP0002166_altered_tumor_susceptibility1.23876432
44MP0003705_abnormal_hypodermis_morpholog1.18899088
45MP0009785_altered_susceptibility_to1.17028264
46MP0004947_skin_inflammation1.16622239
47MP0003300_gastrointestinal_ulcer1.11101384
48MP0009643_abnormal_urine_homeostasis1.10356718
49MP0000537_abnormal_urethra_morphology1.10124637
50MP0002006_tumorigenesis1.06944617
51MP0000462_abnormal_digestive_system1.05810322
52MP0002136_abnormal_kidney_physiology1.02066473
53MP0003252_abnormal_bile_duct1.01070573
54MP0005165_increased_susceptibility_to1.00366319
55MP0005025_abnormal_response_to0.97715058
56MP0003329_amyloid_beta_deposits0.97329602
57MP0005670_abnormal_white_adipose0.96176356
58MP0004019_abnormal_vitamin_homeostasis0.95708249
59MP0005451_abnormal_body_composition0.94024707
60MP0001188_hyperpigmentation0.93933975
61MP0000377_abnormal_hair_follicle0.93873998
62MP0000762_abnormal_tongue_morphology0.90605935
63MP0000230_abnormal_systemic_arterial0.90437786
64MP0001756_abnormal_urination0.90363410
65MP0000470_abnormal_stomach_morphology0.90202615
66MP0005310_abnormal_salivary_gland0.89070446
67MP0001849_ear_inflammation0.85940180
68MP0006082_CNS_inflammation0.82439361
69MP0001845_abnormal_inflammatory_respons0.80827229
70MP0001533_abnormal_skeleton_physiology0.79702123
71MP0009780_abnormal_chondrocyte_physiolo0.79115237
72MP0000579_abnormal_nail_morphology0.79028513
73MP0005319_abnormal_enzyme/_coenzyme0.78757650
74MP0001790_abnormal_immune_system0.78324917
75MP0005387_immune_system_phenotype0.78324917
76MP0002896_abnormal_bone_mineralization0.77095573
77MP0003436_decreased_susceptibility_to0.76761480
78MP0005023_abnormal_wound_healing0.73307450
79MP0003315_abnormal_perineum_morphology0.71965146
80MP0000681_abnormal_thyroid_gland0.70973031
81MP0005666_abnormal_adipose_tissue0.70697296
82MP0009840_abnormal_foam_cell0.66764001
83MP0009333_abnormal_splenocyte_physiolog0.66604853
84MP0003191_abnormal_cellular_cholesterol0.65796955
85MP0008872_abnormal_physiological_respon0.65789261
86MP0005275_abnormal_skin_tensile0.64230754
87MP0001800_abnormal_humoral_immune0.64008058
88MP0002148_abnormal_hypersensitivity_rea0.63615646
89MP0010771_integument_phenotype0.63105029
90MP0009931_abnormal_skin_appearance0.60750490
91MP0004484_altered_response_of0.60574840
92MP0003879_abnormal_hair_cell0.59047522
93MP0001501_abnormal_sleep_pattern0.58664841
94MP0000627_abnormal_mammary_gland0.57206685
95MP0005058_abnormal_lysosome_morphology0.56849933
96MP0002118_abnormal_lipid_homeostasis0.56548950
97MP0003075_altered_response_to0.56396652
98MP0003045_fibrosis0.55957290
99MP0003693_abnormal_embryo_hatching0.55361022
100MP0000609_abnormal_liver_physiology0.55267855

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)7.85935960
2Decreased circulating renin level (HP:0003351)7.68056073
3Abnormality of renin-angiotensin system (HP:0000847)7.40137264
4Abnormality of chloride homeostasis (HP:0011422)5.86980693
5Hyperaldosteronism (HP:0000859)5.48867472
6Alkalosis (HP:0001948)5.44673120
7Right ventricular cardiomyopathy (HP:0011663)5.37082160
8Flat acetabular roof (HP:0003180)5.31354930
9Hyponatremia (HP:0002902)4.48203904
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.87454957
11Hypokalemia (HP:0002900)3.77002923
12Malnutrition (HP:0004395)3.70865955
13Ileus (HP:0002595)3.69870154
14Hyperkalemia (HP:0002153)3.57065087
15Abnormality of potassium homeostasis (HP:0011042)3.56892787
16Pili torti (HP:0003777)3.55944409
17Abdominal distention (HP:0003270)3.52737678
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.49381500
19Abnormality of sodium homeostasis (HP:0010931)3.47093456
20Neonatal short-limb short stature (HP:0008921)3.40497032
21Flattened epiphyses (HP:0003071)3.27673748
22Intrahepatic cholestasis (HP:0001406)3.24305178
23Abnormal tarsal ossification (HP:0008369)3.23974352
24Conjugated hyperbilirubinemia (HP:0002908)3.23961297
25Hemorrhage of the eye (HP:0011885)3.18731348
26Abnormality of small intestinal villus morphology (HP:0011472)3.14140700
27Villous atrophy (HP:0011473)3.14140700
28Abnormal hair laboratory examination (HP:0003328)3.07592247
29Abnormality of the distal phalanx of the thumb (HP:0009617)3.03454699
30Adrenal overactivity (HP:0002717)2.96174443
31Visceral angiomatosis (HP:0100761)2.86233912
32Dehydration (HP:0001944)2.71669242
33Eczematoid dermatitis (HP:0000976)2.60112859
34Flat capital femoral epiphysis (HP:0003370)2.58030019
35Hemangiomatosis (HP:0007461)2.55543339
36Systemic lupus erythematosus (HP:0002725)2.52883508
37Chronic diarrhea (HP:0002028)2.52373114
38Syncope (HP:0001279)2.52210306
39Abnormal biliary tract morphology (HP:0012440)2.43089734
40Spinal cord compression (HP:0002176)2.37104872
41Abnormality of carpal bone ossification (HP:0006257)2.33624143
42Hyperparathyroidism (HP:0000843)2.31980901
43Fat malabsorption (HP:0002630)2.25353181
44Chronic bronchitis (HP:0004469)2.19663963
45Congenital sensorineural hearing impairment (HP:0008527)2.17612416
46Woolly hair (HP:0002224)2.17469831
47Curly hair (HP:0002212)2.16367987
48Palpitations (HP:0001962)2.15440435
49Renal salt wasting (HP:0000127)2.12922674
50Plantar hyperkeratosis (HP:0007556)2.10206701
51Abnormal foot bone ossification (HP:0010675)2.08859470
52Hypotension (HP:0002615)2.07930342
53Palmoplantar hyperkeratosis (HP:0000972)2.06709435
54Abnormality of the 1st metacarpal (HP:0010009)2.05855030
55Hyperactive renin-angiotensin system (HP:0000841)10.7703245
56Focal segmental glomerulosclerosis (HP:0000097)1.99238934
57Hydroxyprolinuria (HP:0003080)1.94371250
58Abnormality of proline metabolism (HP:0010907)1.94371250
59Abnormality of the nasal mucosa (HP:0000433)1.93850131
60Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.93277206
61Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.92591962
62Vertebral hypoplasia (HP:0008417)1.92591962
63Abnormality of the vitamin B12 metabolism (HP:0004341)1.90948376
64Palmar hyperkeratosis (HP:0010765)1.89111307
65Renal tubular acidosis (HP:0001947)1.89006430
66Breech presentation (HP:0001623)1.88299152
67Thin bony cortex (HP:0002753)1.87453050
68Dicarboxylic aciduria (HP:0003215)1.87271666
69Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87271666
70Abnormal vertebral ossification (HP:0100569)1.86499197
71Biliary tract neoplasm (HP:0100574)1.85684123
72Alopecia of scalp (HP:0002293)1.81841721
73Hyperammonemia (HP:0001987)1.81358033
74Abnormal cartilage morphology (HP:0002763)1.80342797
75Premature loss of primary teeth (HP:0006323)1.79478897
76Abnormal hand bone ossification (HP:0010660)1.78313410
77Ventricular fibrillation (HP:0001663)1.77817113
78Hoarse voice (HP:0001609)1.77394126
79Vertebral clefting (HP:0008428)1.77188796
80Growth hormone excess (HP:0000845)1.76865959
81Abnormality of vitamin B metabolism (HP:0004340)1.74270465
82Symphalangism affecting the phalanges of the hand (HP:0009773)1.73980502
83Abnormal ossification of hand bones (HP:0005921)1.73946102
84Petechiae (HP:0000967)1.72747511
85Nephritis (HP:0000123)1.71994915
86Glomerulonephritis (HP:0000099)1.71636794
87Severe short stature (HP:0003510)1.71100598
88Cerebral palsy (HP:0100021)1.70031890
89Glomerulosclerosis (HP:0000096)1.69571576
90Hyperphosphatemia (HP:0002905)1.68039065
91Mildly elevated creatine phosphokinase (HP:0008180)1.66296973
92Abnormality of the gastric mucosa (HP:0004295)1.66079716
93Bone pain (HP:0002653)1.65349699
94Aplasia/hypoplasia of the femur (HP:0005613)1.64193079
95Abnormality of complement system (HP:0005339)1.61870890
96Partial duplication of thumb phalanx (HP:0009944)1.60899739
97Oral leukoplakia (HP:0002745)1.59007737
98Amelogenesis imperfecta (HP:0000705)1.58700034
99Symptomatic seizures (HP:0011145)1.58007065
100Abnormality of vitamin metabolism (HP:0100508)1.57131806

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R7.26168691
2PIK3CA6.13556763
3EPHA25.65951662
4RIPK14.28430458
5ACVR1B4.09108061
6LMTK23.83808969
7ERN12.96695461
8MET2.88885893
9EPHB22.48929033
10STK241.90915443
11STK391.85414506
12PRKG21.66951069
13MAP3K101.63215621
14PTK61.63045048
15MAP3K121.61969893
16MAP3K21.57570485
17PDK21.25035152
18MAPKAPK31.22814061
19TESK11.22761634
20TESK21.21398137
21FGFR41.12644243
22OXSR11.10330346
23EPHA31.10284534
24EPHB11.09951003
25WNK41.06706385
26FGFR31.02931765
27MYLK0.98171571
28DDR20.95804810
29FER0.95788931
30PRPF4B0.95347732
31RIPK40.95054252
32TAOK10.94562590
33MST40.88984408
34TYK20.87504912
35MAP2K20.87258945
36MAP3K10.85530576
37PDPK10.80563388
38CAMK2D0.80499187
39MAP2K60.75839157
40GRK60.74899579
41MATK0.72854069
42DMPK0.72670564
43CDC42BPA0.70208848
44MAP3K30.66579374
45ABL20.66038891
46PAK40.64237930
47PTK20.62728457
48ERBB20.61255927
49KSR20.59400773
50MAP3K60.58874287
51TRIB30.54806131
52PDK10.49428613
53ZAP700.48861374
54NLK0.47625513
55MAPKAPK20.47481499
56PRKAA20.46910552
57MAP3K140.46720169
58SMG10.46051887
59BMPR20.45573301
60NME10.43258299
61CSK0.41682082
62SRC0.40558010
63MAPK110.39605815
64BMX0.38390373
65RET0.37745841
66TBK10.35730845
67PRKCI0.33816193
68JAK10.31884788
69MAP4K10.31651091
70IRAK10.30088704
71JAK20.29775931
72PRKCA0.29483477
73YES10.27310182
74TNIK0.26055416
75PDGFRA0.26044763
76PRKACG0.25903877
77FYN0.24730723
78MAP3K110.24316428
79MAP2K10.24136125
80MAPK70.22669888
81NEK60.22361471
82MAP3K130.22314472
83PKN20.21447140
84CSNK1A10.21327553
85RPS6KA20.21212749
86IKBKE0.20476190
87EPHA40.20284428
88IGF1R0.19601257
89SIK10.18414303
90LYN0.18192849
91PRKCD0.17983531
92GRK10.14922720
93PDGFRB0.13738078
94DYRK1B0.13470547
95RPS6KB20.11318965
96PRKCQ0.11306018
97ERBB30.10930474
98LRRK20.10173648
99PIM20.10073377
100WNK10.08863869

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.36233344
2Nitrogen metabolism_Homo sapiens_hsa009104.51701306
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049644.08797078
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.81776952
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.65632421
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.77865612
7Mineral absorption_Homo sapiens_hsa049782.58295994
8Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.43215767
9Caffeine metabolism_Homo sapiens_hsa002322.41630196
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.41394885
11Fat digestion and absorption_Homo sapiens_hsa049752.33616198
12Arginine biosynthesis_Homo sapiens_hsa002202.27235577
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05340710
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.81454811
15Histidine metabolism_Homo sapiens_hsa003401.78765271
16Retinol metabolism_Homo sapiens_hsa008301.62351835
17Bile secretion_Homo sapiens_hsa049761.60169366
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.58814459
19Fatty acid degradation_Homo sapiens_hsa000711.55902278
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.51310689
21Fructose and mannose metabolism_Homo sapiens_hsa000511.47240218
22Starch and sucrose metabolism_Homo sapiens_hsa005001.38960951
23* Pancreatic secretion_Homo sapiens_hsa049721.34817002
24PPAR signaling pathway_Homo sapiens_hsa033201.34783934
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33621827
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26410273
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25288101
28Chemical carcinogenesis_Homo sapiens_hsa052041.23299157
29Renin-angiotensin system_Homo sapiens_hsa046141.20495940
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17674895
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13956645
32Arginine and proline metabolism_Homo sapiens_hsa003301.13465846
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11106770
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06086828
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00339751
36Other glycan degradation_Homo sapiens_hsa005110.99473884
37Intestinal immune network for IgA production_Homo sapiens_hsa046720.98925892
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98604111
39Galactose metabolism_Homo sapiens_hsa000520.92835711
40Sulfur relay system_Homo sapiens_hsa041220.91247245
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89481721
42Leukocyte transendothelial migration_Homo sapiens_hsa046700.85699034
43Asthma_Homo sapiens_hsa053100.82410902
44Tight junction_Homo sapiens_hsa045300.81215282
45Glycerolipid metabolism_Homo sapiens_hsa005610.80927173
46Protein digestion and absorption_Homo sapiens_hsa049740.77251822
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76803682
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.71964345
49Hepatitis C_Homo sapiens_hsa051600.70427666
50Tryptophan metabolism_Homo sapiens_hsa003800.66852034
51Allograft rejection_Homo sapiens_hsa053300.64549052
52Autoimmune thyroid disease_Homo sapiens_hsa053200.60226115
53Linoleic acid metabolism_Homo sapiens_hsa005910.57403544
54Ether lipid metabolism_Homo sapiens_hsa005650.56537759
55Graft-versus-host disease_Homo sapiens_hsa053320.56288525
56Staphylococcus aureus infection_Homo sapiens_hsa051500.55674381
57Arachidonic acid metabolism_Homo sapiens_hsa005900.54745381
58Pertussis_Homo sapiens_hsa051330.53933917
59Fatty acid metabolism_Homo sapiens_hsa012120.53258315
60Thyroid hormone synthesis_Homo sapiens_hsa049180.52014453
61Glutathione metabolism_Homo sapiens_hsa004800.49829582
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47668579
63Sphingolipid metabolism_Homo sapiens_hsa006000.43447468
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40420695
65Type I diabetes mellitus_Homo sapiens_hsa049400.38923029
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38899316
67Leishmaniasis_Homo sapiens_hsa051400.38654749
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37918537
69Butanoate metabolism_Homo sapiens_hsa006500.37643489
70Amoebiasis_Homo sapiens_hsa051460.37257230
71Salmonella infection_Homo sapiens_hsa051320.36734266
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.35737792
73Vibrio cholerae infection_Homo sapiens_hsa051100.34449454
74Tyrosine metabolism_Homo sapiens_hsa003500.34072369
75Peroxisome_Homo sapiens_hsa041460.33725952
76Phenylalanine metabolism_Homo sapiens_hsa003600.31370911
77Antigen processing and presentation_Homo sapiens_hsa046120.31178836
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30838953
79Toxoplasmosis_Homo sapiens_hsa051450.25357206
80Influenza A_Homo sapiens_hsa051640.24957862
81GnRH signaling pathway_Homo sapiens_hsa049120.24597168
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23592275
83Propanoate metabolism_Homo sapiens_hsa006400.21774433
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21296714
85Carbon metabolism_Homo sapiens_hsa012000.18566787
86Thyroid cancer_Homo sapiens_hsa052160.18105839
87Tuberculosis_Homo sapiens_hsa051520.17940128
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.17867263
89Gastric acid secretion_Homo sapiens_hsa049710.16697137
90Pyruvate metabolism_Homo sapiens_hsa006200.16505541
91Viral myocarditis_Homo sapiens_hsa054160.15213252
92Vitamin digestion and absorption_Homo sapiens_hsa049770.15044861
93Insulin resistance_Homo sapiens_hsa049310.13792931
94African trypanosomiasis_Homo sapiens_hsa051430.12743820
95Choline metabolism in cancer_Homo sapiens_hsa052310.12022944
96TNF signaling pathway_Homo sapiens_hsa046680.11227938
97Endocytosis_Homo sapiens_hsa041440.10498437
98Metabolic pathways_Homo sapiens_hsa011000.07931699
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.07847139
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.07631634

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