CLCC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.27326878
2L-phenylalanine catabolic process (GO:0006559)5.27326878
3aromatic amino acid family catabolic process (GO:0009074)5.04436237
4L-phenylalanine metabolic process (GO:0006558)4.95084553
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.95084553
6tryptophan catabolic process (GO:0006569)4.87204369
7indole-containing compound catabolic process (GO:0042436)4.87204369
8indolalkylamine catabolic process (GO:0046218)4.87204369
9tryptophan metabolic process (GO:0006568)4.63986116
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.53255916
11cellular glucuronidation (GO:0052695)4.49104722
12bile acid biosynthetic process (GO:0006699)4.40552347
13high-density lipoprotein particle remodeling (GO:0034375)4.30059632
14glyoxylate metabolic process (GO:0046487)4.28967035
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.19406563
16kynurenine metabolic process (GO:0070189)4.18615122
17regulation of protein activation cascade (GO:2000257)4.10211534
18sulfur amino acid catabolic process (GO:0000098)4.09672485
19urea metabolic process (GO:0019627)4.08901480
20urea cycle (GO:0000050)4.08901480
21uronic acid metabolic process (GO:0006063)4.06969399
22glucuronate metabolic process (GO:0019585)4.06969399
23low-density lipoprotein particle remodeling (GO:0034374)3.99834816
24cysteine metabolic process (GO:0006534)3.97152073
25homocysteine metabolic process (GO:0050667)3.96583195
26reverse cholesterol transport (GO:0043691)3.95855905
27complement activation, alternative pathway (GO:0006957)3.92697870
28macromolecular complex remodeling (GO:0034367)3.90580430
29plasma lipoprotein particle remodeling (GO:0034369)3.90580430
30protein-lipid complex remodeling (GO:0034368)3.90580430
31regulation of complement activation (GO:0030449)3.89636813
32amino-acid betaine metabolic process (GO:0006577)3.89268519
33alpha-linolenic acid metabolic process (GO:0036109)3.89227733
34bile acid metabolic process (GO:0008206)3.80887384
35amine catabolic process (GO:0009310)3.79238741
36cellular biogenic amine catabolic process (GO:0042402)3.79238741
37protein carboxylation (GO:0018214)3.76655980
38peptidyl-glutamic acid carboxylation (GO:0017187)3.76655980
39nitrogen cycle metabolic process (GO:0071941)3.76258588
40response to nitrosative stress (GO:0051409)3.67250592
41regulation of cholesterol esterification (GO:0010872)3.60843551
42aromatic amino acid family metabolic process (GO:0009072)3.57492729
43lysine metabolic process (GO:0006553)3.56369154
44lysine catabolic process (GO:0006554)3.56369154
45aldehyde catabolic process (GO:0046185)3.53750115
46serine family amino acid catabolic process (GO:0009071)3.52302828
47phospholipid efflux (GO:0033700)3.49927052
48indolalkylamine metabolic process (GO:0006586)3.47691036
49imidazole-containing compound metabolic process (GO:0052803)3.44921827
50ethanol oxidation (GO:0006069)3.43068027
51tyrosine metabolic process (GO:0006570)3.42252552
52regulation of fibrinolysis (GO:0051917)3.41634656
53valine metabolic process (GO:0006573)3.41180295
54bile acid and bile salt transport (GO:0015721)3.40773747
55negative regulation of fibrinolysis (GO:0051918)3.40272002
56regulation of triglyceride catabolic process (GO:0010896)3.38399802
57alpha-amino acid catabolic process (GO:1901606)3.35691159
58negative regulation of lipase activity (GO:0060192)3.34736708
59pyridine nucleotide biosynthetic process (GO:0019363)3.32638755
60nicotinamide nucleotide biosynthetic process (GO:0019359)3.32638755
61NAD biosynthetic process (GO:0009435)3.32375713
62fibrinolysis (GO:0042730)3.30211173
63carnitine metabolic process (GO:0009437)3.26166957
64benzene-containing compound metabolic process (GO:0042537)3.25601471
65cholesterol efflux (GO:0033344)3.23552994
66response to pheromone (GO:0019236)3.23172686
67detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.22761473
68cellular ketone body metabolic process (GO:0046950)3.22709660
69complement activation (GO:0006956)3.20553722
70complement activation, classical pathway (GO:0006958)3.16874257
71cofactor catabolic process (GO:0051187)3.16275730
72blood coagulation, intrinsic pathway (GO:0007597)3.16199078
73protein activation cascade (GO:0072376)3.14742503
74short-chain fatty acid metabolic process (GO:0046459)3.12693076
75triglyceride homeostasis (GO:0070328)3.12391049
76acylglycerol homeostasis (GO:0055090)3.12391049
77plasma lipoprotein particle organization (GO:0071827)3.09752074
78fatty acid beta-oxidation (GO:0006635)3.06353184
79cellular amino acid catabolic process (GO:0009063)3.05482177
80replication fork processing (GO:0031297)3.03961992
81urate metabolic process (GO:0046415)3.02854404
82fatty acid oxidation (GO:0019395)3.02833172
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.02191727
84lipid oxidation (GO:0034440)3.01899437
85xenobiotic catabolic process (GO:0042178)2.99985959
86monocarboxylic acid catabolic process (GO:0072329)2.98930791
87flavonoid metabolic process (GO:0009812)2.97639372
88S-adenosylmethionine metabolic process (GO:0046500)2.97182652
89plasma lipoprotein particle assembly (GO:0034377)2.96266757
90glycine metabolic process (GO:0006544)2.93759998
91organic acid catabolic process (GO:0016054)2.93751516
92carboxylic acid catabolic process (GO:0046395)2.93751516
93coenzyme catabolic process (GO:0009109)2.93714281
94drug transmembrane transport (GO:0006855)2.91932347
95lipoprotein metabolic process (GO:0042157)2.91589462
96opsonization (GO:0008228)2.91550365
97serine family amino acid metabolic process (GO:0009069)2.91309296
98serine family amino acid biosynthetic process (GO:0009070)2.90301209
99protein K6-linked ubiquitination (GO:0085020)2.89982225
100branched-chain amino acid catabolic process (GO:0009083)2.88940977
101fatty acid catabolic process (GO:0009062)2.88163230
102behavioral response to nicotine (GO:0035095)2.86165808
103very-low-density lipoprotein particle assembly (GO:0034379)2.86144712
104drug catabolic process (GO:0042737)2.85999366
105plasma lipoprotein particle clearance (GO:0034381)2.85952135
106mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83743050
107mitochondrial respiratory chain complex I assembly (GO:0032981)2.83743050
108NADH dehydrogenase complex assembly (GO:0010257)2.83743050
109protein complex biogenesis (GO:0070271)2.82380939
110mitochondrial respiratory chain complex assembly (GO:0033108)2.80871591
111ketone body metabolic process (GO:1902224)2.78535176
112respiratory chain complex IV assembly (GO:0008535)2.74911342
113nonmotile primary cilium assembly (GO:0035058)2.74805306
114regulation of sarcomere organization (GO:0060297)2.71850186
115postreplication repair (GO:0006301)2.69050390
116regulation of hexokinase activity (GO:1903299)2.68056753
117regulation of glucokinase activity (GO:0033131)2.68056753
118platelet dense granule organization (GO:0060155)2.63615522
119negative regulation of DNA-dependent DNA replication (GO:2000104)2.62999139
120ubiquinone biosynthetic process (GO:0006744)2.62055084
121regulation of centriole replication (GO:0046599)2.61432686
122synapsis (GO:0007129)2.60886251
123ubiquinone metabolic process (GO:0006743)2.60467537
124water-soluble vitamin biosynthetic process (GO:0042364)2.55988148
125fucose catabolic process (GO:0019317)2.55498793
126L-fucose metabolic process (GO:0042354)2.55498793
127L-fucose catabolic process (GO:0042355)2.55498793
128ribonucleoprotein complex disassembly (GO:0032988)2.53302560
129meiotic chromosome segregation (GO:0045132)2.50417215
130reciprocal meiotic recombination (GO:0007131)2.48576623
131reciprocal DNA recombination (GO:0035825)2.48576623
132mitochondrial RNA metabolic process (GO:0000959)2.47322131
133organelle disassembly (GO:1903008)2.44864876
134L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.44816295
135pancreas development (GO:0031016)2.44771815
136maturation of 5.8S rRNA (GO:0000460)2.43299065
137recombinational repair (GO:0000725)2.43214532
138protein polyglutamylation (GO:0018095)2.40733880
139L-methionine biosynthetic process (GO:0071265)2.39563770
140amino acid salvage (GO:0043102)2.39563770
141L-methionine salvage (GO:0071267)2.39563770
142methionine biosynthetic process (GO:0009086)2.39223238
143double-strand break repair via homologous recombination (GO:0000724)2.38194377
144renal tubule morphogenesis (GO:0061333)2.37469845
145translesion synthesis (GO:0019985)2.36425474
146protein-cofactor linkage (GO:0018065)2.36293604
147cilium morphogenesis (GO:0060271)2.35228734
148kinetochore organization (GO:0051383)2.34732568
149regulation of hippo signaling (GO:0035330)2.34540768
150peptidyl-histidine modification (GO:0018202)2.32509093
151presynaptic membrane assembly (GO:0097105)2.30972223
152nephron tubule morphogenesis (GO:0072078)2.30428595
153nephron epithelium morphogenesis (GO:0072088)2.30428595
154intraciliary transport (GO:0042073)2.30413218
155regulation of action potential (GO:0098900)2.29811449
156cytochrome complex assembly (GO:0017004)2.29609286
157histone H2A acetylation (GO:0043968)2.27955786
158hindbrain development (GO:0030902)2.27178150
159regulation of nuclear cell cycle DNA replication (GO:0033262)2.26911076
160regulation of DNA endoreduplication (GO:0032875)2.26220843
161positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.26127709
162glycerophospholipid catabolic process (GO:0046475)2.25598969
163negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.23514411
164regulation of cilium movement (GO:0003352)2.22969892
165DNA damage induced protein phosphorylation (GO:0006975)2.22826985
166maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.22801601
167cilium organization (GO:0044782)2.21845153
168resolution of meiotic recombination intermediates (GO:0000712)2.20683139
169anterograde synaptic vesicle transport (GO:0048490)2.18369025
170reflex (GO:0060004)2.18327421
171regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.17245587
172cilium assembly (GO:0042384)2.16858007
173negative regulation of cytosolic calcium ion concentration (GO:0051481)2.16151370
174behavioral response to ethanol (GO:0048149)2.14941833
175detection of light stimulus involved in visual perception (GO:0050908)2.14054859
176detection of light stimulus involved in sensory perception (GO:0050962)2.14054859
177positive regulation of glycolytic process (GO:0045821)2.13649459
178cornea development in camera-type eye (GO:0061303)2.13306546
179anterograde axon cargo transport (GO:0008089)2.13300125
180regulation of centrosome cycle (GO:0046605)2.12966800
181C4-dicarboxylate transport (GO:0015740)2.12612659
182mannosylation (GO:0097502)2.11968369
183DNA replication checkpoint (GO:0000076)2.11366867
184aspartate family amino acid biosynthetic process (GO:0009067)2.10346999
185isoprenoid biosynthetic process (GO:0008299)2.09581350
186oxidative demethylation (GO:0070989)2.09440404
187lipid particle organization (GO:0034389)2.08196748
188piRNA metabolic process (GO:0034587)2.05883967
189kinetochore assembly (GO:0051382)2.05667068
190microtubule organizing center organization (GO:0031023)2.05224810
191brain morphogenesis (GO:0048854)2.04376342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.55887145
2EGR1_23403033_ChIP-Seq_LIVER_Mouse5.92078556
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.25496876
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.43577551
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.19047132
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.12495520
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.00954338
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.86092818
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.21303036
10ZNF274_21170338_ChIP-Seq_K562_Hela3.19591794
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.06453966
12SALL1_21062744_ChIP-ChIP_HESCs_Human3.02502464
13GBX2_23144817_ChIP-Seq_PC3_Human2.93253117
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.76323872
15VDR_22108803_ChIP-Seq_LS180_Human2.69835791
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51183271
17FUS_26573619_Chip-Seq_HEK293_Human2.51034731
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50456277
19EWS_26573619_Chip-Seq_HEK293_Human2.44121511
20IGF1R_20145208_ChIP-Seq_DFB_Human2.43238933
21* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.33572287
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27937293
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25720390
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23713090
25GATA1_22025678_ChIP-Seq_K562_Human2.14476652
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.06922624
27ELK1_19687146_ChIP-ChIP_HELA_Human2.04000523
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.01749999
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94543131
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.92453165
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.91198377
32TAF15_26573619_Chip-Seq_HEK293_Human1.88630831
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85409796
34HTT_18923047_ChIP-ChIP_STHdh_Human1.85227618
35P300_19829295_ChIP-Seq_ESCs_Human1.85183061
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.84806173
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81901373
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76712795
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.74778599
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73264570
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71181881
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69485530
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65639966
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.63481240
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.63357371
46ER_23166858_ChIP-Seq_MCF-7_Human1.62445533
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59431124
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.59343560
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58765513
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58329735
51SMAD4_21799915_ChIP-Seq_A2780_Human1.55167121
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54722091
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54616820
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53610892
55STAT3_23295773_ChIP-Seq_U87_Human1.52265093
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50979815
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49047291
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.46839368
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.46712922
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46413596
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44715161
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44628998
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43244427
64AR_21909140_ChIP-Seq_LNCAP_Human1.40768871
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39533274
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38864103
67* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37066971
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35607330
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33616490
70CBP_20019798_ChIP-Seq_JUKART_Human1.33616490
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32713883
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31667492
73KAP1_22055183_ChIP-Seq_ESCs_Mouse1.31560304
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31404730
75* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30274757
76TCF4_23295773_ChIP-Seq_U87_Human1.29593792
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29573310
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29527880
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.29281605
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27880894
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25259054
82* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23922787
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.23624690
84VDR_23849224_ChIP-Seq_CD4+_Human1.22985157
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.22154273
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21789887
87AR_25329375_ChIP-Seq_VCAP_Human1.19266074
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19098715
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18738177
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17955924
91RNF2_27304074_Chip-Seq_NSC_Mouse1.16809630
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16694149
93FLI1_27457419_Chip-Seq_LIVER_Mouse1.16216797
94JUN_21703547_ChIP-Seq_K562_Human1.16118847
95P53_22387025_ChIP-Seq_ESCs_Mouse1.15963616
96TP53_22573176_ChIP-Seq_HFKS_Human1.15430245
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15265006
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14677740
99MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14520850
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12886488
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12313044
102FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11904117
103STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11773745
104* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11194485
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.10879356
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10351376
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10015924
108SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09440316
109E2F7_22180533_ChIP-Seq_HELA_Human1.09271192
110NANOG_19829295_ChIP-Seq_ESCs_Human1.09209159
111SOX2_19829295_ChIP-Seq_ESCs_Human1.09209159
112ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08479047
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.08346651
114TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08334442
115CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08153705
116FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07740193
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06085707
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.05959911
119POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05918356
120FOXM1_23109430_ChIP-Seq_U2OS_Human1.05089339
121RUNX2_22187159_ChIP-Seq_PCA_Human1.04791790
122FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04268453
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03072899
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99569630
125CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99424675
126TCF4_22108803_ChIP-Seq_LS180_Human0.99403820
127FLI1_21867929_ChIP-Seq_TH2_Mouse0.98911421
128MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97866592
129PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97866116
130SCL_19346495_ChIP-Seq_HPC-7_Human0.97562463
131AR_20517297_ChIP-Seq_VCAP_Human0.96568286
132CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96278179
133STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96227750
134SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95033651
135IRF1_19129219_ChIP-ChIP_H3396_Human0.94918470
136NOTCH1_21737748_ChIP-Seq_TLL_Human0.94863555
137BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94092435
138* GATA3_26560356_Chip-Seq_TH2_Human0.93453470
139LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93442272
140BCAT_22108803_ChIP-Seq_LS180_Human0.93419363
141SPI1_23547873_ChIP-Seq_NB4_Human0.93343906
142* TBL1_22424771_ChIP-Seq_293T_Human0.93128459
143CMYC_18555785_Chip-Seq_ESCs_Mouse0.92684531
144SMAD4_21741376_ChIP-Seq_EPCs_Human0.92670314
145CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92461127
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91458558
147CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88987442
148RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88219211
149CLOCK_20551151_ChIP-Seq_293T_Human0.87979372
150GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87708344
151ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86841153
152NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85848034
153NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85848034
154NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.85591847
155CRX_20693478_ChIP-Seq_RETINA_Mouse0.83976611
156GATA4_25053715_ChIP-Seq_YYC3_Human0.83886468
157GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83849603
158POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83682189
159MYC_18940864_ChIP-ChIP_HL60_Human0.83559746
160SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.83005880
161GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82598200
162CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82531059
163MYB_26560356_Chip-Seq_TH1_Human0.82394883
164HNF4A_19822575_ChIP-Seq_HepG2_Human0.81120121
165CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81090406
166RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80482115
167RUNX_20019798_ChIP-Seq_JUKART_Human0.80131511
168CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79786966
169FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79494350
170FOXA2_19822575_ChIP-Seq_HepG2_Human0.77825566
171CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77686788
172FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.77124243
173BRD4_27068464_Chip-Seq_AML-cells_Mouse0.76914000
174STAT1_17558387_ChIP-Seq_HELA_Human0.76819853
175AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76643506
176FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.74751687
177PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74267866
178CDX2_22108803_ChIP-Seq_LS180_Human0.72633142
179FOXA1_25552417_ChIP-Seq_VCAP_Human0.72505817
180STAT3_18555785_Chip-Seq_ESCs_Mouse0.71762588
181FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71104084

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.68175138
2MP0005360_urolithiasis5.61573645
3MP0005365_abnormal_bile_salt4.69834024
4MP0005085_abnormal_gallbladder_physiolo4.55015208
5MP0008875_abnormal_xenobiotic_pharmacok4.04252043
6MP0003806_abnormal_nucleotide_metabolis3.15108467
7MP0003195_calcinosis3.07796633
8MP0003252_abnormal_bile_duct2.99909553
9MP0010329_abnormal_lipoprotein_level2.52367957
10MP0009840_abnormal_foam_cell2.40873990
11MP0000569_abnormal_digit_pigmentation2.36103141
12MP0002102_abnormal_ear_morphology2.34669977
13MP0003724_increased_susceptibility_to2.31172332
14MP0002938_white_spotting2.21017262
15MP0005332_abnormal_amino_acid2.12372324
16MP0003191_abnormal_cellular_cholesterol2.08476706
17MP0009697_abnormal_copulation2.08384992
18MP0008058_abnormal_DNA_repair2.01533563
19MP0001666_abnormal_nutrient_absorption2.00946514
20MP0001764_abnormal_homeostasis1.95097750
21MP0003283_abnormal_digestive_organ1.93972585
22MP0008877_abnormal_DNA_methylation1.89887877
23MP0003186_abnormal_redox_activity1.87469248
24MP0003950_abnormal_plasma_membrane1.86339828
25MP0006072_abnormal_retinal_apoptosis1.81925194
26MP0000427_abnormal_hair_cycle1.81803252
27MP0002138_abnormal_hepatobiliary_system1.80500211
28MP0002837_dystrophic_cardiac_calcinosis1.78906203
29MP0005551_abnormal_eye_electrophysiolog1.72747068
30MP0001529_abnormal_vocalization1.70596999
31MP0009780_abnormal_chondrocyte_physiolo1.69886886
32MP0005083_abnormal_biliary_tract1.66598075
33MP0000609_abnormal_liver_physiology1.66283018
34MP0006292_abnormal_olfactory_placode1.64264919
35MP0005451_abnormal_body_composition1.62948221
36MP0005645_abnormal_hypothalamus_physiol1.57569411
37MP0001835_abnormal_antigen_presentation1.56907651
38MP0009764_decreased_sensitivity_to1.55692177
39MP0009785_altered_susceptibility_to1.55230575
40MP0005319_abnormal_enzyme/_coenzyme1.54483150
41MP0010094_abnormal_chromosome_stability1.52553830
42MP0005670_abnormal_white_adipose1.52543581
43MP0004019_abnormal_vitamin_homeostasis1.50369448
44MP0005408_hypopigmentation1.49242191
45MP0001984_abnormal_olfaction1.49085714
46MP0005253_abnormal_eye_physiology1.49046271
47MP0000372_irregular_coat_pigmentation1.48511271
48MP0006276_abnormal_autonomic_nervous1.47881664
49MP0002638_abnormal_pupillary_reflex1.44710006
50MP0002118_abnormal_lipid_homeostasis1.41419231
51MP0008775_abnormal_heart_ventricle1.39762173
52MP0003136_yellow_coat_color1.39032735
53MP0004142_abnormal_muscle_tone1.38314548
54MP0009046_muscle_twitch1.38276392
55MP0004133_heterotaxia1.37916310
56MP0001853_heart_inflammation1.37588396
57MP0000383_abnormal_hair_follicle1.37543680
58MP0008469_abnormal_protein_level1.35764574
59MP0003656_abnormal_erythrocyte_physiolo1.35164023
60MP0003937_abnormal_limbs/digits/tail_de1.33928947
61MP0005647_abnormal_sex_gland1.33593740
62MP0003718_maternal_effect1.33047082
63MP0008007_abnormal_cellular_replicative1.32645114
64MP0002160_abnormal_reproductive_system1.31360871
65MP0005058_abnormal_lysosome_morphology1.31280719
66MP0000647_abnormal_sebaceous_gland1.29173482
67MP0002419_abnormal_innate_immunity1.27336382
68MP0000778_abnormal_nervous_system1.24826777
69MP0003646_muscle_fatigue1.24277951
70MP0009643_abnormal_urine_homeostasis1.23326747
71MP0003436_decreased_susceptibility_to1.23074080
72MP0004145_abnormal_muscle_electrophysio1.22471694
73MP0004215_abnormal_myocardial_fiber1.22207859
74MP0006054_spinal_hemorrhage1.22206968
75MP0003011_delayed_dark_adaptation1.21387221
76MP0004084_abnormal_cardiac_muscle1.21057777
77MP0006082_CNS_inflammation1.20908923
78MP0009763_increased_sensitivity_to1.20768034
79MP0000631_abnormal_neuroendocrine_gland1.19886215
80MP0009384_cardiac_valve_regurgitation1.19610211
81MP0005171_absent_coat_pigmentation1.19402318
82MP0003868_abnormal_feces_composition1.18714313
83MP0008057_abnormal_DNA_replication1.18405902
84MP0005584_abnormal_enzyme/coenzyme_acti1.17962675
85MP0002234_abnormal_pharynx_morphology1.17747107
86MP0003121_genomic_imprinting1.16902242
87MP0002132_abnormal_respiratory_system1.16763122
88MP0004782_abnormal_surfactant_physiolog1.14736759
89MP0003787_abnormal_imprinting1.14298879
90MP0005464_abnormal_platelet_physiology1.13403139
91MP0010368_abnormal_lymphatic_system1.11676614
92MP0001485_abnormal_pinna_reflex1.08666692
93MP0004885_abnormal_endolymph1.04952642
94MP0003890_abnormal_embryonic-extraembry1.04702709
95MP0002254_reproductive_system_inflammat1.03280098
96MP0005025_abnormal_response_to1.02144630
97MP0005187_abnormal_penis_morphology1.00962864
98MP0004147_increased_porphyrin_level0.99518139
99MP0000598_abnormal_liver_morphology0.99290545
100MP0005671_abnormal_response_to0.97015995
101MP0005636_abnormal_mineral_homeostasis0.96397144
102MP0001293_anophthalmia0.95563720
103MP0005195_abnormal_posterior_eye0.95525930
104MP0003567_abnormal_fetal_cardiomyocyte0.95189676
105MP0001324_abnormal_eye_pigmentation0.93871310
106MP0000013_abnormal_adipose_tissue0.93280279
107MP0002396_abnormal_hematopoietic_system0.93041481
108MP0000465_gastrointestinal_hemorrhage0.92638531
109MP0002876_abnormal_thyroid_physiology0.92572398
110MP0002928_abnormal_bile_duct0.91854304
111MP0002184_abnormal_innervation0.91831290
112MP0003690_abnormal_glial_cell0.90628859
113MP0002557_abnormal_social/conspecific_i0.90563290
114MP0003880_abnormal_central_pattern0.90298841
115MP0001968_abnormal_touch/_nociception0.90121808
116MP0003122_maternal_imprinting0.88788244
117MP0001845_abnormal_inflammatory_respons0.88509216
118MP0005391_vision/eye_phenotype0.88061981
119MP0003763_abnormal_thymus_physiology0.87705982
120MP0005386_behavior/neurological_phenoty0.87010801
121MP0004924_abnormal_behavior0.87010801
122MP0002736_abnormal_nociception_after0.86968656
123MP0001790_abnormal_immune_system0.86627481
124MP0005387_immune_system_phenotype0.86627481
125MP0000685_abnormal_immune_system0.86625841
126MP0005220_abnormal_exocrine_pancreas0.86095888
127MP0002909_abnormal_adrenal_gland0.85219341
128MP0008789_abnormal_olfactory_epithelium0.85049180
129MP0002272_abnormal_nervous_system0.84948482
130MP0005389_reproductive_system_phenotype0.84915119
131MP0006036_abnormal_mitochondrial_physio0.83914708
132MP0001299_abnormal_eye_distance/0.83637480
133MP0005395_other_phenotype0.83344950
134MP0001986_abnormal_taste_sensitivity0.83341367
135MP0004043_abnormal_pH_regulation0.83326527
136MP0005376_homeostasis/metabolism_phenot0.83092554
137MP0004381_abnormal_hair_follicle0.82503184
138MP0002166_altered_tumor_susceptibility0.82356478
139MP0003755_abnormal_palate_morphology0.81176404
140MP0002148_abnormal_hypersensitivity_rea0.80589632
141MP0008932_abnormal_embryonic_tissue0.80189114
142MP0000516_abnormal_urinary_system0.79999086
143MP0005367_renal/urinary_system_phenotyp0.79999086
144MP0010678_abnormal_skin_adnexa0.79630324
145MP0005646_abnormal_pituitary_gland0.79603042
146MP0003693_abnormal_embryo_hatching0.79543446
147MP0001800_abnormal_humoral_immune0.79355464
148MP0000749_muscle_degeneration0.79067287
149MP0008872_abnormal_physiological_respon0.78788091
150MP0004270_analgesia0.78239123
151MP0005084_abnormal_gallbladder_morpholo0.77181984
152MP0009642_abnormal_blood_homeostasis0.76718523
153MP0002233_abnormal_nose_morphology0.76573045
154MP0002735_abnormal_chemical_nociception0.76524117
155MP0002723_abnormal_immune_serum0.76461415
156MP0002751_abnormal_autonomic_nervous0.76252318
157MP0003077_abnormal_cell_cycle0.75351994
158MP0010155_abnormal_intestine_physiology0.75349132
159MP0001286_abnormal_eye_development0.74812397
160MP0009745_abnormal_behavioral_response0.74765216
161MP0001119_abnormal_female_reproductive0.74270934
162MP0002452_abnormal_antigen_presenting0.74049917
163MP0002269_muscular_atrophy0.73718963
164MP0005000_abnormal_immune_tolerance0.72530687
165MP0010386_abnormal_urinary_bladder0.71848728
166MP0001944_abnormal_pancreas_morphology0.71275783
167MP0003385_abnormal_body_wall0.71210674
168MP0005075_abnormal_melanosome_morpholog0.69296095
169MP0001533_abnormal_skeleton_physiology0.69295126
170MP0001919_abnormal_reproductive_system0.69163520
171MP0009765_abnormal_xenobiotic_induced0.65704469
172MP0002060_abnormal_skin_morphology0.63413984
173MP0005266_abnormal_metabolism0.63157574
174MP0002405_respiratory_system_inflammati0.63132946
175MP0002136_abnormal_kidney_physiology0.62736919
176MP0000343_altered_response_to0.62418581
177MP0000689_abnormal_spleen_morphology0.60090330
178MP0002420_abnormal_adaptive_immunity0.59744893
179MP0005164_abnormal_response_to0.59238462
180MP0001542_abnormal_bone_strength0.58582628
181MP0001819_abnormal_immune_cell0.58332676
182MP0003300_gastrointestinal_ulcer0.58278174
183MP0002006_tumorigenesis0.57289206
184MP0000566_synostosis0.57048793
185MP0005397_hematopoietic_system_phenotyp0.55729645
186MP0001545_abnormal_hematopoietic_system0.55729645

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)4.99484163
2Deep venous thrombosis (HP:0002625)4.86958341
3Intrahepatic cholestasis (HP:0001406)4.84594632
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.72502541
5Hypobetalipoproteinemia (HP:0003563)4.40256416
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.20726828
7Joint hemorrhage (HP:0005261)4.13245283
8Complement deficiency (HP:0004431)4.12436199
9Xanthomatosis (HP:0000991)4.02269721
10Pancreatic cysts (HP:0001737)3.79020732
11Pancreatic fibrosis (HP:0100732)3.75024458
12True hermaphroditism (HP:0010459)3.70260474
13Abnormality of methionine metabolism (HP:0010901)3.62739333
14Hypolipoproteinemia (HP:0010981)3.58151311
15Abnormality of aspartate family amino acid metabolism (HP:0010899)3.44246005
16Abnormality of the common coagulation pathway (HP:0010990)3.38414208
17Systemic lupus erythematosus (HP:0002725)3.38190712
18Abnormality of complement system (HP:0005339)3.38033858
19Abnormality of midbrain morphology (HP:0002418)3.33344044
20Molar tooth sign on MRI (HP:0002419)3.33344044
21Hyperammonemia (HP:0001987)3.32437084
22Hyperlipoproteinemia (HP:0010980)3.31370258
23Hypoalphalipoproteinemia (HP:0003233)3.27947010
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.25285770
25Abnormality of the intrinsic pathway (HP:0010989)3.24911830
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.17908782
27Fat malabsorption (HP:0002630)3.15531695
28Nephronophthisis (HP:0000090)3.09687767
29Renal cortical cysts (HP:0000803)3.07373956
30Abnormality of fatty-acid metabolism (HP:0004359)3.05249191
31Hypercholesterolemia (HP:0003124)3.04975328
32Hyperglycinuria (HP:0003108)3.00936957
33Type II lissencephaly (HP:0007260)2.97787114
34Abnormality of the renal medulla (HP:0100957)2.95178464
35Generalized aminoaciduria (HP:0002909)2.92614447
36Abnormality of pyrimidine metabolism (HP:0004353)2.92543199
37Ketosis (HP:0001946)2.83496352
38Hypoglycemic coma (HP:0001325)2.82256117
39Hyperglycinemia (HP:0002154)2.81403302
40Abnormality of serine family amino acid metabolism (HP:0010894)2.78854625
41Abnormality of glycine metabolism (HP:0010895)2.78854625
42Hyperventilation (HP:0002883)2.75604770
43Tubulointerstitial nephritis (HP:0001970)2.75416458
44Medial flaring of the eyebrow (HP:0010747)2.72667191
45Recurrent gram-negative bacterial infections (HP:0005420)2.71108894
46Hyperbilirubinemia (HP:0002904)2.70866906
47Steatorrhea (HP:0002570)2.70384880
48Conjugated hyperbilirubinemia (HP:0002908)2.70337143
49Abnormality of serum amino acid levels (HP:0003112)2.69030801
50Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.65588474
51Reduced antithrombin III activity (HP:0001976)2.64098602
52Epidermoid cyst (HP:0200040)2.61939349
53Dicarboxylic aciduria (HP:0003215)2.58778050
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.58778050
55Cerebellar dysplasia (HP:0007033)2.57805095
56Abnormality of glutamine family amino acid metabolism (HP:0010902)2.57284835
57Abnormality of nucleobase metabolism (HP:0010932)2.52484347
58Gingival bleeding (HP:0000225)2.47218245
59Nausea (HP:0002018)2.44548857
603-Methylglutaconic aciduria (HP:0003535)2.38486414
61Cerebral palsy (HP:0100021)2.36342135
62Sclerocornea (HP:0000647)2.36023519
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.35236307
64Amyloidosis (HP:0011034)2.34111107
65Glomerulonephritis (HP:0000099)2.33379081
66Abnormality of purine metabolism (HP:0004352)2.32454921
67Metabolic acidosis (HP:0001942)2.31418565
68Myocardial infarction (HP:0001658)2.31228690
69Cystic liver disease (HP:0006706)2.29066628
70Calf muscle hypertrophy (HP:0008981)2.27833210
71Intestinal atresia (HP:0011100)2.27682821
72Keratoconus (HP:0000563)2.27121399
73Increased corneal curvature (HP:0100692)2.27121399
74Hepatocellular carcinoma (HP:0001402)2.25561792
75Hypoplasia of the thymus (HP:0000778)2.23766946
76Ketoacidosis (HP:0001993)2.23655245
77Increased serum pyruvate (HP:0003542)2.22960492
78Lethargy (HP:0001254)2.22438734
79Abnormality of the labia minora (HP:0012880)2.19760596
80Proximal tubulopathy (HP:0000114)2.19313442
81Aplasia/Hypoplasia of the uvula (HP:0010293)2.19076969
82Inability to walk (HP:0002540)2.18265972
83Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17581962
84Postaxial foot polydactyly (HP:0001830)2.15626843
85Aplasia/Hypoplasia of the tibia (HP:0005772)2.14000808
86Chronic hepatic failure (HP:0100626)2.13767000
87Anencephaly (HP:0002323)2.13704647
88Chromsome breakage (HP:0040012)2.13447561
89Glycosuria (HP:0003076)2.13439334
90Abnormality of urine glucose concentration (HP:0011016)2.13439334
91Congenital primary aphakia (HP:0007707)2.12682362
92Abnormality of glycolysis (HP:0004366)2.11621759
93Broad-based gait (HP:0002136)2.10698506
94Cerebral edema (HP:0002181)2.08472024
95Furrowed tongue (HP:0000221)2.08114611
96Abnormality of the renal cortex (HP:0011035)2.07622198
97Gait imbalance (HP:0002141)2.07377036
98Lissencephaly (HP:0001339)2.05885414
99Nephrogenic diabetes insipidus (HP:0009806)2.04484949
100Menorrhagia (HP:0000132)2.03330720
101Recurrent bacterial skin infections (HP:0005406)2.02284600
102Elevated hepatic transaminases (HP:0002910)2.02120892
103Abnormality of alanine metabolism (HP:0010916)2.01891573
104Hyperalaninemia (HP:0003348)2.01891573
105Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01891573
106Congenital hepatic fibrosis (HP:0002612)2.00072047
107Tubular atrophy (HP:0000092)1.99704783
108Purpura (HP:0000979)1.99301375
109Recurrent abscess formation (HP:0002722)1.98964059
110Progressive inability to walk (HP:0002505)1.98717232
111Pendular nystagmus (HP:0012043)1.98154191
112Congenital stationary night blindness (HP:0007642)1.96831620
113Muscle hypertrophy of the lower extremities (HP:0008968)1.96345060
114Fair hair (HP:0002286)1.95207674
115Hepatic necrosis (HP:0002605)1.95000581
116Petechiae (HP:0000967)1.94507393
117Abolished electroretinogram (ERG) (HP:0000550)1.93680566
118Bile duct proliferation (HP:0001408)1.92708101
119Abnormal biliary tract physiology (HP:0012439)1.92708101
120Pancreatitis (HP:0001733)1.91893751
121Thrombophlebitis (HP:0004418)1.90792293
122Vacuolated lymphocytes (HP:0001922)1.90779078
123Attenuation of retinal blood vessels (HP:0007843)1.90743915
124Pachygyria (HP:0001302)1.90663245
125Tubulointerstitial abnormality (HP:0001969)1.89884859
126Pheochromocytoma (HP:0002666)1.89630127
127Drooling (HP:0002307)1.89278414
128Partial agenesis of the corpus callosum (HP:0001338)1.89237452
129Methylmalonic acidemia (HP:0002912)1.88970567
130Genital tract atresia (HP:0001827)1.88838191
131Epistaxis (HP:0000421)1.87285287
132Sloping forehead (HP:0000340)1.86567564
133Large for gestational age (HP:0001520)1.86104016
134Meckel diverticulum (HP:0002245)1.85786119
135Acanthocytosis (HP:0001927)1.85653667
136Dandy-Walker malformation (HP:0001305)1.84383170
137Hypergonadotropic hypogonadism (HP:0000815)1.83980727
138Acute necrotizing encephalopathy (HP:0006965)1.83320074
139Abnormality of the ileum (HP:0001549)1.83296058
140Progressive macrocephaly (HP:0004481)1.82674057
141Vascular calcification (HP:0004934)1.81866824
142Gastrointestinal atresia (HP:0002589)1.81752522
143Type I transferrin isoform profile (HP:0003642)1.80599638
144Chorioretinal atrophy (HP:0000533)1.80098112
145Oligodactyly (hands) (HP:0001180)1.77986691
146Short tibia (HP:0005736)1.77741542
147Acute encephalopathy (HP:0006846)1.77456355
148Autoimmune thrombocytopenia (HP:0001973)1.76295183
149Vaginal atresia (HP:0000148)1.75895460
150Preaxial hand polydactyly (HP:0001177)1.75604045
151Abnormality of the prostate (HP:0008775)1.75336869
152Abnormal platelet volume (HP:0011876)1.75251954
153Mitral stenosis (HP:0001718)1.75211671
154Abnormality of chromosome stability (HP:0003220)1.74344456
155Increased CSF lactate (HP:0002490)1.73792226
156Optic nerve hypoplasia (HP:0000609)1.73284640
157Astigmatism (HP:0000483)1.73171083
158Abnormality of the heme biosynthetic pathway (HP:0010472)1.71800140
159Male pseudohermaphroditism (HP:0000037)1.71237325
160Abnormality of DNA repair (HP:0003254)1.71183489
161Nephritis (HP:0000123)1.70253997
162IgM deficiency (HP:0002850)1.69634310
163Postaxial hand polydactyly (HP:0001162)1.69476889
164Vomiting (HP:0002013)1.68316644
165Abnormality of the carotid arteries (HP:0005344)1.67687211
166Delayed CNS myelination (HP:0002188)1.67395198
167Periodontitis (HP:0000704)1.67221252
168Esophageal varix (HP:0002040)1.66975161
169Enlarged kidneys (HP:0000105)1.66322667
170Neuroendocrine neoplasm (HP:0100634)1.65922696
171Poikilocytosis (HP:0004447)1.65449932
172Spastic diplegia (HP:0001264)1.64930053
173Spontaneous abortion (HP:0005268)1.64910286
174Hypochromic microcytic anemia (HP:0004840)1.64745955
175Volvulus (HP:0002580)1.62840343
176Absent speech (HP:0001344)1.62725617
177Poor coordination (HP:0002370)1.62545766
178Abnormal mitochondria in muscle tissue (HP:0008316)1.61434870
179Aganglionic megacolon (HP:0002251)1.60024414
180Oligohydramnios (HP:0001562)1.59705635
181Tachypnea (HP:0002789)1.58361871
182Retinal dysplasia (HP:0007973)1.58361252
183Glioma (HP:0009733)1.58164373
184Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.57466697
185Meningioma (HP:0002858)1.57229021
186Occipital encephalocele (HP:0002085)1.57171689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK2.98958874
2PBK2.84538995
3TAOK32.82589520
4CASK2.64628853
5IRAK32.63085407
6MAP3K142.44375475
7MAP4K22.34266708
8TGFBR22.31839455
9MAPK152.29175167
10TYK22.12200732
11MUSK2.03327588
12PLK41.93416521
13TEC1.93085107
14NEK91.92703357
15TXK1.90345199
16TNIK1.88532584
17WNK41.80837859
18EIF2AK31.79030795
19BTK1.71321909
20PNCK1.64225709
21IRAK41.61472476
22MAP3K31.60926587
23MST41.60675343
24ZAK1.60093724
25PINK11.60006563
26FGFR41.56024992
27FLT31.55441169
28MKNK21.54344377
29SIK11.52696198
30NEK11.52355824
31BMPR21.50710583
32WNK31.47090094
33STK391.46270448
34STK241.45124866
35INSRR1.44994228
36PLK31.44673001
37ERBB41.43312237
38PLK21.43028927
39TIE11.41451107
40NUAK11.32882737
41MAP3K41.32021588
42KIT1.31510718
43STK101.31077623
44MAP4K11.30995854
45IKBKE1.28167882
46TRIM281.28025154
47STK38L1.24054047
48ERN11.21650568
49JAK31.19247394
50KDR1.18364660
51TTK1.17993816
52TSSK61.17528945
53BCR1.17340697
54MAPKAPK31.16618467
55FRK1.15159056
56MAPK131.12386669
57BUB11.11687139
58VRK11.10759706
59CSF1R1.10708537
60PAK31.09420236
61MAP2K31.09082290
62CSNK1G11.08487334
63SRPK11.08203416
64EIF2AK21.08000539
65PIK3CG1.07374287
66PHKG21.07141258
67PHKG11.07141258
68PRKCE1.06081684
69NTRK31.05403206
70TLK11.04995617
71MAPKAPK51.04461279
72BMPR1B1.04221408
73TBK11.03983298
74MAPK111.02111405
75CDK80.99278476
76JAK10.98850550
77NEK20.98694512
78STK160.98369101
79STK30.96665760
80BRSK20.95829173
81GRK10.95036746
82EIF2AK10.93279857
83PLK10.92029291
84CSNK1G20.91006455
85TRPM70.89812212
86MAP3K60.89336700
87MARK10.88113567
88ITK0.88101992
89STK40.87931947
90GRK70.87643356
91AKT30.87461067
92JAK20.86358629
93CCNB10.85734052
94LATS10.85721462
95BRSK10.85273580
96CSNK1G30.85248653
97CSNK1A1L0.84538755
98OBSCN0.82286914
99LYN0.81307474
100IKBKB0.80121630
101MYLK0.79965247
102PRKCG0.79620531
103ACVR1B0.79298839
104TGFBR10.77490248
105CHUK0.76232642
106OXSR10.76172268
107MAPK120.75709873
108MET0.73153729
109PIK3CA0.69628797
110MAP2K70.68608527
111ATM0.68249254
112ZAP700.67640266
113FGFR20.65745544
114PRKAA20.63860810
115PKN20.63776848
116MAP2K60.61384199
117IRAK10.61313707
118CHEK20.61146013
119ADRBK10.60648521
120CDK30.59734319
121MOS0.59070398
122IRAK20.58882307
123NLK0.58343372
124RPS6KB20.56959300
125TNK20.56777531
126RPS6KA40.56312450
127AURKB0.55767013
128MAPK70.53445652
129CAMK1G0.52535198
130ATR0.52203616
131TAF10.51792119
132EPHA30.50735687
133MAPK40.50662236
134PRKAA10.50319845
135ERBB30.50003715
136WEE10.49941082
137ADRBK20.49720217
138CDK60.48862401
139CSNK1E0.48723913
140NME20.48102956
141ABL20.47623071
142ABL10.45942950
143NME10.44762919
144IGF1R0.44588044
145SGK20.44016776
146CSNK1D0.43441634
147SYK0.43325802
148CDC70.42020599
149PRKCQ0.41972627
150PTK2B0.41612807
151CAMKK20.41534341
152FER0.41500616
153LCK0.41029333
154MKNK10.40775095
155PDK20.40715783
156CLK10.40448105
157DYRK20.40312765
158RPS6KA50.40222215
159PRKACB0.37475342

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.69333979
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36090136
3Pentose and glucuronate interconversions_Homo sapiens_hsa000402.98582838
4Complement and coagulation cascades_Homo sapiens_hsa046102.67410050
5Fatty acid degradation_Homo sapiens_hsa000712.46180165
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.33758819
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.27929766
8Peroxisome_Homo sapiens_hsa041462.24112781
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21731578
10Tryptophan metabolism_Homo sapiens_hsa003802.20574276
11Staphylococcus aureus infection_Homo sapiens_hsa051502.20005833
12Drug metabolism - other enzymes_Homo sapiens_hsa009832.08711934
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06006894
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.02519668
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.97823955
16Chemical carcinogenesis_Homo sapiens_hsa052041.96293576
17Arginine biosynthesis_Homo sapiens_hsa002201.93718687
18Propanoate metabolism_Homo sapiens_hsa006401.93363633
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.89817433
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81064277
21Histidine metabolism_Homo sapiens_hsa003401.81036592
22Retinol metabolism_Homo sapiens_hsa008301.75948306
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75597000
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.72017070
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.69467787
26beta-Alanine metabolism_Homo sapiens_hsa004101.63597761
27Fatty acid metabolism_Homo sapiens_hsa012121.63338756
28Caffeine metabolism_Homo sapiens_hsa002321.59544992
29Basal transcription factors_Homo sapiens_hsa030221.58963327
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56329241
31ABC transporters_Homo sapiens_hsa020101.55796050
32RNA polymerase_Homo sapiens_hsa030201.55328138
33Oxidative phosphorylation_Homo sapiens_hsa001901.54102599
34Butanoate metabolism_Homo sapiens_hsa006501.52643680
35PPAR signaling pathway_Homo sapiens_hsa033201.52611691
36Folate biosynthesis_Homo sapiens_hsa007901.51063682
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49526443
38Sulfur metabolism_Homo sapiens_hsa009201.47531177
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43829752
40Starch and sucrose metabolism_Homo sapiens_hsa005001.41082981
41Selenocompound metabolism_Homo sapiens_hsa004501.40697108
42Nitrogen metabolism_Homo sapiens_hsa009101.40480552
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.38496519
44Phototransduction_Homo sapiens_hsa047441.36957982
45RNA degradation_Homo sapiens_hsa030181.32749866
46Nucleotide excision repair_Homo sapiens_hsa034201.30835197
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.27202168
48Phenylalanine metabolism_Homo sapiens_hsa003601.24458493
49Fatty acid elongation_Homo sapiens_hsa000621.23178233
50One carbon pool by folate_Homo sapiens_hsa006701.23073665
51Tyrosine metabolism_Homo sapiens_hsa003501.22219499
52Pyruvate metabolism_Homo sapiens_hsa006201.20710135
53Parkinsons disease_Homo sapiens_hsa050121.18404235
54Protein export_Homo sapiens_hsa030601.14381889
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.12954524
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12554638
57Vitamin digestion and absorption_Homo sapiens_hsa049771.09861153
58Nicotine addiction_Homo sapiens_hsa050331.08672103
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08195220
60Proteasome_Homo sapiens_hsa030501.07149640
61Glycosaminoglycan degradation_Homo sapiens_hsa005311.03273618
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02448993
63Ether lipid metabolism_Homo sapiens_hsa005650.97850656
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97290621
65Arginine and proline metabolism_Homo sapiens_hsa003300.94956765
66Glutathione metabolism_Homo sapiens_hsa004800.94892285
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93136508
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91788432
69Purine metabolism_Homo sapiens_hsa002300.90674567
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90033033
71Carbon metabolism_Homo sapiens_hsa012000.88536872
72RNA transport_Homo sapiens_hsa030130.88447225
73Biosynthesis of amino acids_Homo sapiens_hsa012300.84494386
74Alzheimers disease_Homo sapiens_hsa050100.83173616
75Huntingtons disease_Homo sapiens_hsa050160.82706909
76Bile secretion_Homo sapiens_hsa049760.80527052
77Steroid biosynthesis_Homo sapiens_hsa001000.79910687
78Other glycan degradation_Homo sapiens_hsa005110.78587925
79Pentose phosphate pathway_Homo sapiens_hsa000300.78450718
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76514594
81Vitamin B6 metabolism_Homo sapiens_hsa007500.69809109
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69153771
83DNA replication_Homo sapiens_hsa030300.68903299
84Regulation of autophagy_Homo sapiens_hsa041400.68367300
85Cardiac muscle contraction_Homo sapiens_hsa042600.66929741
86Metabolic pathways_Homo sapiens_hsa011000.65439083
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64979457
88Circadian rhythm_Homo sapiens_hsa047100.63919781
89Lysine degradation_Homo sapiens_hsa003100.63849062
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.63072051
91Galactose metabolism_Homo sapiens_hsa000520.61245199
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.58975993
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58115439
94Homologous recombination_Homo sapiens_hsa034400.57577926
95Insulin secretion_Homo sapiens_hsa049110.56707754
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56706829
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54749892
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53907439
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51727271
100Fat digestion and absorption_Homo sapiens_hsa049750.51685514
101Pyrimidine metabolism_Homo sapiens_hsa002400.51527528
102Arachidonic acid metabolism_Homo sapiens_hsa005900.51018434
103Cell cycle_Homo sapiens_hsa041100.50485045
104TGF-beta signaling pathway_Homo sapiens_hsa043500.49765593
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48896124
106Glycerolipid metabolism_Homo sapiens_hsa005610.48690050
107Base excision repair_Homo sapiens_hsa034100.44438598
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43624151
109Taste transduction_Homo sapiens_hsa047420.42605562
110p53 signaling pathway_Homo sapiens_hsa041150.41859233
111N-Glycan biosynthesis_Homo sapiens_hsa005100.41354222
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41353537
113Non-homologous end-joining_Homo sapiens_hsa034500.41337609
114Olfactory transduction_Homo sapiens_hsa047400.39790401
115Oocyte meiosis_Homo sapiens_hsa041140.39141752
116Ovarian steroidogenesis_Homo sapiens_hsa049130.39057816
117Spliceosome_Homo sapiens_hsa030400.38962210
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37956785
119Legionellosis_Homo sapiens_hsa051340.37921874
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36760461
121Circadian entrainment_Homo sapiens_hsa047130.35933333
122Malaria_Homo sapiens_hsa051440.35125000
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31788772
124Hematopoietic cell lineage_Homo sapiens_hsa046400.30726597
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30574457
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.30365453
127Fructose and mannose metabolism_Homo sapiens_hsa000510.29590435
128Herpes simplex infection_Homo sapiens_hsa051680.29583542
129Linoleic acid metabolism_Homo sapiens_hsa005910.29103941
130Primary immunodeficiency_Homo sapiens_hsa053400.27288372
131Graft-versus-host disease_Homo sapiens_hsa053320.27225163
132Antigen processing and presentation_Homo sapiens_hsa046120.26230367
133Leishmaniasis_Homo sapiens_hsa051400.24921417
134Lysosome_Homo sapiens_hsa041420.24650977
135Pertussis_Homo sapiens_hsa051330.24544521
136Fanconi anemia pathway_Homo sapiens_hsa034600.24517487
137Sulfur relay system_Homo sapiens_hsa041220.24490219
138Mismatch repair_Homo sapiens_hsa034300.24380296

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