CLCF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.30037671
2regulation of interleukin-12 biosynthetic process (GO:0045075)4.86250605
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.75279993
4regulation of chronic inflammatory response (GO:0002676)4.75175917
5response to peptidoglycan (GO:0032494)4.65385241
6antigen processing and presentation of endogenous antigen (GO:0019883)4.54264091
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.45057370
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.45057370
9leukocyte aggregation (GO:0070486)4.45029365
10regulation of cytokine secretion involved in immune response (GO:0002739)4.36275530
11positive thymic T cell selection (GO:0045059)4.25070690
12regulation of podosome assembly (GO:0071801)4.18637709
13positive regulation of heat generation (GO:0031652)4.15658274
14regulation of membrane protein ectodomain proteolysis (GO:0051043)4.06477113
15regulation of fever generation (GO:0031620)4.02105048
16regulation of gamma-delta T cell differentiation (GO:0045586)3.97838967
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.91021767
18positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.90516435
19negative regulation of nitric oxide biosynthetic process (GO:0045019)3.87993881
20branching involved in labyrinthine layer morphogenesis (GO:0060670)3.86268381
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.84432463
22regulation of gamma-delta T cell activation (GO:0046643)3.78237311
23negative thymic T cell selection (GO:0045060)3.69832184
24regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.63116280
25negative T cell selection (GO:0043383)3.60943407
26cellular response to nicotine (GO:0071316)3.56591157
27negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.52655707
28regulation of B cell differentiation (GO:0045577)3.46995908
29regulation of alpha-beta T cell proliferation (GO:0046640)3.44516985
30interferon-gamma production (GO:0032609)3.43351804
31negative regulation of cell killing (GO:0031342)3.42841064
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.42841064
33regulation of nitric oxide biosynthetic process (GO:0045428)3.41484361
34activation of MAPKKK activity (GO:0000185)3.38083703
35NIK/NF-kappaB signaling (GO:0038061)3.37188678
36negative regulation of cytokine production involved in immune response (GO:0002719)3.36002737
37thymic T cell selection (GO:0045061)3.35984283
38T cell migration (GO:0072678)3.34651727
39positive regulation of interleukin-2 production (GO:0032743)3.32943443
40leukocyte cell-cell adhesion (GO:0007159)3.31674519
41regulation of T cell tolerance induction (GO:0002664)3.30692783
42regulation of B cell receptor signaling pathway (GO:0050855)3.29340483
43regulation of immunoglobulin secretion (GO:0051023)3.28229591
44B cell receptor signaling pathway (GO:0050853)3.26410228
45positive T cell selection (GO:0043368)3.26382468
46positive regulation of NF-kappaB import into nucleus (GO:0042346)3.25621342
47positive regulation of nitric oxide biosynthetic process (GO:0045429)3.25288810
48response to interleukin-15 (GO:0070672)3.22307617
49response to muramyl dipeptide (GO:0032495)3.16188969
50germinal center formation (GO:0002467)3.15626342
51positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14062709
52regulation of T-helper 2 cell differentiation (GO:0045628)3.13772224
53adhesion of symbiont to host cell (GO:0044650)3.13540893
54virion attachment to host cell (GO:0019062)3.13540893
55positive regulation of interferon-alpha production (GO:0032727)3.13310088
56regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.12313388
57positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.10215490
58cellular response to lipopolysaccharide (GO:0071222)3.07879824
59regulation of heterotypic cell-cell adhesion (GO:0034114)3.06478048
60protein localization to endosome (GO:0036010)3.04769247
61regulation of mononuclear cell migration (GO:0071675)3.04494523
62positive regulation of type 2 immune response (GO:0002830)3.02661546
63positive regulation of chemokine biosynthetic process (GO:0045080)3.01127823
64T cell selection (GO:0045058)2.99781473
65macrophage activation involved in immune response (GO:0002281)2.98766023
66T-helper 1 type immune response (GO:0042088)2.98542878
67response to protozoan (GO:0001562)2.98417752
68neutrophil activation involved in immune response (GO:0002283)2.98071639
69negative regulation of lipid storage (GO:0010888)2.97348537
70regulation of isotype switching to IgG isotypes (GO:0048302)2.96839109
71myeloid dendritic cell differentiation (GO:0043011)2.96537543
72regulation of interferon-alpha production (GO:0032647)2.96454773
73cellular response to zinc ion (GO:0071294)2.95457549
74JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.95432470
75regulation of heat generation (GO:0031650)2.94949031
76decidualization (GO:0046697)2.94503284
77cellular response to molecule of bacterial origin (GO:0071219)2.94067232
78positive regulation of B cell differentiation (GO:0045579)2.92043822
79positive regulation of interleukin-6 production (GO:0032755)2.91555902
80regulation of vitamin D biosynthetic process (GO:0060556)2.91264118
81interferon-gamma-mediated signaling pathway (GO:0060333)2.91078316
82regulation of apoptotic process involved in morphogenesis (GO:1902337)2.89703183
83positive regulation of transcription factor import into nucleus (GO:0042993)2.88512911
84myeloid dendritic cell activation (GO:0001773)2.87660720
85positive regulation of natural killer cell differentiation (GO:0032825)2.87569461
86immunoglobulin mediated immune response (GO:0016064)2.87564061
87positive regulation of T-helper cell differentiation (GO:0045624)2.87071794
88defense response to protozoan (GO:0042832)2.86605710
89antigen receptor-mediated signaling pathway (GO:0050851)2.86125324
90T cell receptor signaling pathway (GO:0050852)2.84326609
91cellular response to interleukin-15 (GO:0071350)2.84180152
92regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.84158092
93regulation of interleukin-8 biosynthetic process (GO:0045414)2.83899161
94regulation of dendritic cell antigen processing and presentation (GO:0002604)2.83384350
95negative regulation of interleukin-12 production (GO:0032695)2.83138375
96positive regulation of humoral immune response (GO:0002922)2.82734767
97regulation of NF-kappaB import into nucleus (GO:0042345)2.82078240
98regulation of T-helper 1 cell differentiation (GO:0045625)2.81243034
99positive regulation of macrophage differentiation (GO:0045651)2.80708129
100positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.80400221
101regulation of T-helper cell differentiation (GO:0045622)2.79855651
102T cell costimulation (GO:0031295)2.79560836
103response to progesterone (GO:0032570)2.79181426
104* positive regulation of isotype switching (GO:0045830)2.78596363
105cellular response to interferon-alpha (GO:0035457)2.78580950
106positive regulation of acute inflammatory response (GO:0002675)2.78166913
107positive regulation of cytokine biosynthetic process (GO:0042108)2.77142973
108regulation of type 2 immune response (GO:0002828)2.76542605
109heterotypic cell-cell adhesion (GO:0034113)2.75058963
110natural killer cell differentiation (GO:0001779)2.75024457
111adhesion of symbiont to host (GO:0044406)2.75002055
112response to type I interferon (GO:0034340)2.73570491
113regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.73569499
114lymphocyte costimulation (GO:0031294)2.73146624
115response to laminar fluid shear stress (GO:0034616)2.73126424
116regulation of interleukin-2 biosynthetic process (GO:0045076)2.72836459
117positive regulation of Cdc42 GTPase activity (GO:0043089)2.72662689
118* positive regulation of immunoglobulin mediated immune response (GO:0002891)2.72238772
119* positive regulation of B cell mediated immunity (GO:0002714)2.72238772
120regulation of T cell receptor signaling pathway (GO:0050856)2.71899125
121regulation of interferon-beta biosynthetic process (GO:0045357)2.70872927
122positive regulation of lymphocyte apoptotic process (GO:0070230)2.70575351
123mature B cell differentiation (GO:0002335)2.68398443
124negative regulation of viral genome replication (GO:0045071)2.68321355
125regulation of tolerance induction (GO:0002643)2.67521504
126cell adhesion mediated by integrin (GO:0033627)2.67155753
127positive regulation of tolerance induction (GO:0002645)2.66777399
128natural killer cell activation (GO:0030101)2.66295410
129cellular response to virus (GO:0098586)2.66176185
130granulocyte activation (GO:0036230)2.65746127
131dendritic cell differentiation (GO:0097028)2.64270490
132positive regulation of interferon-beta production (GO:0032728)2.63773677
133cellular response to type I interferon (GO:0071357)2.63235022
134type I interferon signaling pathway (GO:0060337)2.63235022
135positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.62991187
136regulation of interleukin-6 production (GO:0032675)2.62873202
137positive regulation of interleukin-12 production (GO:0032735)2.62534188
138regulation of type I interferon-mediated signaling pathway (GO:0060338)2.62314414
139regulation of interleukin-12 production (GO:0032655)2.61354624
140wound healing, spreading of epidermal cells (GO:0035313)2.60321529
141positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.60108307
142mature B cell differentiation involved in immune response (GO:0002313)2.59871232
143chronic inflammatory response (GO:0002544)2.59448127
144interferon-gamma secretion (GO:0072643)2.59398035
145regulation of regulatory T cell differentiation (GO:0045589)2.58245058
146positive regulation of chemokine production (GO:0032722)2.57175574
147regulation of necroptotic process (GO:0060544)2.56868329
148monocyte chemotaxis (GO:0002548)2.56508879
149neutrophil activation (GO:0042119)2.56447037
150regulation of chemokine biosynthetic process (GO:0045073)2.56255950
151negative regulation of myeloid cell apoptotic process (GO:0033033)2.56052577
152cellular response to biotic stimulus (GO:0071216)2.56004324
153negative regulation of production of molecular mediator of immune response (GO:0002701)2.55841454
154lipopolysaccharide-mediated signaling pathway (GO:0031663)2.55098111
155tyrosine phosphorylation of STAT protein (GO:0007260)2.54942389
156positive regulation of natural killer cell activation (GO:0032816)2.54516828
157regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.53669293
158regulation of response to interferon-gamma (GO:0060330)2.53354667
159positive regulation by symbiont of host defense response (GO:0052509)2.53167647
160modulation by symbiont of host defense response (GO:0052031)2.53167647
161modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.53167647
162modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.53167647
163positive regulation by organism of defense response of other organism involved in symbiotic interact2.53167647
164modulation by symbiont of host immune response (GO:0052553)2.53167647
165skin morphogenesis (GO:0043589)2.53077811
166membrane raft organization (GO:0031579)2.51373026
167regulation of vitamin metabolic process (GO:0030656)2.50930963
168substrate-dependent cell migration (GO:0006929)2.50190272
169oligosaccharide catabolic process (GO:0009313)2.49683067
170response to manganese ion (GO:0010042)2.49560593
171glycosphingolipid catabolic process (GO:0046479)2.49402562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.58430878
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.80775920
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.51274669
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.86247963
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.60526137
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.40475586
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.28297501
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.04586526
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.00191541
10MYC_22102868_ChIP-Seq_BL_Human2.98441928
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.96424544
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.77028027
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.75735716
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74554020
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.71100196
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.70422936
17* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.68635438
18* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62066209
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57850512
20RUNX_20019798_ChIP-Seq_JUKART_Human2.55111399
21* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.51808286
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.45123107
23* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.44309172
24MYB_26560356_Chip-Seq_TH2_Human2.44066226
25* MAF_26560356_Chip-Seq_TH1_Human2.34696241
26VDR_21846776_ChIP-Seq_THP-1_Human2.25476534
27MYB_26560356_Chip-Seq_TH1_Human2.16805239
28UTX_26944678_Chip-Seq_JUKART_Human2.09220266
29TCF7_22412390_ChIP-Seq_EML_Mouse2.02170241
30* ESR2_21235772_ChIP-Seq_MCF-7_Human2.00342427
31BRD4_27068464_Chip-Seq_AML-cells_Mouse2.00108823
32VDR_24763502_ChIP-Seq_THP-1_Human1.98810639
33SCL_19346495_ChIP-Seq_HPC-7_Human1.95924658
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.94015096
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92209061
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91749177
37* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89930211
38* ELK3_25401928_ChIP-Seq_HUVEC_Human1.88054501
39SPI1_23547873_ChIP-Seq_NB4_Human1.83976623
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.80791269
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77631132
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71349720
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.70420086
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70173057
45LXR_22292898_ChIP-Seq_THP-1_Human1.69863621
46* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67819774
47* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67350208
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.62086302
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60236719
50* KDM2B_26808549_Chip-Seq_DND41_Human1.59684628
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.56850329
52* RACK7_27058665_Chip-Seq_MCF-7_Human1.56653241
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56295801
54* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55092564
55* ESR1_21235772_ChIP-Seq_MCF-7_Human1.52389913
56GATA3_27048872_Chip-Seq_THYMUS_Human1.47050190
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45334910
58SPI1_23127762_ChIP-Seq_K562_Human1.43944540
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42447792
60MAF_26560356_Chip-Seq_TH2_Human1.40439451
61PU_27001747_Chip-Seq_BMDM_Mouse1.37412848
62CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.35391187
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32856336
64ZNF263_19887448_ChIP-Seq_K562_Human1.31641009
65* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29859714
66* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29859714
67* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28596665
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26546663
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25983491
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24139150
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23435908
72TRIM28_21343339_ChIP-Seq_HEK293_Human1.22395696
73* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17344418
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16932545
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16018935
76CLOCK_20551151_ChIP-Seq_293T_Human1.14827407
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14562152
78* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12591838
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.11988594
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11758367
81E2F7_22180533_ChIP-Seq_HELA_Human1.11694454
82* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11543959
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11385770
84VDR_24787735_ChIP-Seq_THP-1_Human1.08593176
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08080061
86* KDM2B_26808549_Chip-Seq_K562_Human1.07930230
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06440592
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05969640
89* NCOR1_26117541_ChIP-Seq_K562_Human1.05249794
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05186671
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.04856540
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03229139
93TP53_22127205_ChIP-Seq_IMR90_Human1.02018899
94* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01379924
95GATA3_26560356_Chip-Seq_TH2_Human1.01036762
96SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00494466
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00372602
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.00372568
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99586167
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98649780
101JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98520876
102* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98279228
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97497240
104* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97211689
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95862398
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95634151
107* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94785220
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94013261
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93997032
110ATF3_27146783_Chip-Seq_COLON_Human0.92591702
111* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91666057
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91603070
113PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91456426
114RXR_22158963_ChIP-Seq_LIVER_Mouse0.91082279
115UBF1/2_26484160_Chip-Seq_HMECs_Human0.90696406
116* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88639049
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88027731
118* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86519750
119BRD4_25478319_ChIP-Seq_HGPS_Human0.85493512
120* CJUN_26792858_Chip-Seq_BT549_Human0.85448219
121JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85034522
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84524153
123PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82297491
124P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81995590
125* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81579488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.66257368
2MP0003436_decreased_susceptibility_to3.04449902
3MP0005671_abnormal_response_to2.92960404
4MP0000685_abnormal_immune_system2.92440737
5MP0003303_peritoneal_inflammation2.86669277
6MP0001790_abnormal_immune_system2.82384915
7MP0005387_immune_system_phenotype2.82384915
8MP0009785_altered_susceptibility_to2.81487575
9MP0005058_abnormal_lysosome_morphology2.76448319
10MP0005000_abnormal_immune_tolerance2.73054999
11MP0001800_abnormal_humoral_immune2.72440847
12MP0003763_abnormal_thymus_physiology2.56401995
13MP0002452_abnormal_antigen_presenting2.54987937
14MP0003300_gastrointestinal_ulcer2.52314419
15MP0005451_abnormal_body_composition2.44715969
16MP0002723_abnormal_immune_serum2.38460050
17MP0002148_abnormal_hypersensitivity_rea2.31535766
18MP0009840_abnormal_foam_cell2.31461964
19MP0005025_abnormal_response_to2.28930996
20MP0002420_abnormal_adaptive_immunity2.27369036
21MP0001819_abnormal_immune_cell2.25861655
22MP0002419_abnormal_innate_immunity2.17392727
23MP0010352_gastrointestinal_tract_polyps2.16653813
24MP0006082_CNS_inflammation2.13485380
25MP0002006_tumorigenesis2.10358453
26MP0002405_respiratory_system_inflammati2.06855111
27MP0009333_abnormal_splenocyte_physiolog2.01380805
28MP0002398_abnormal_bone_marrow2.01187041
29MP0004947_skin_inflammation2.00937310
30MP0002332_abnormal_exercise_endurance1.99674250
31MP0002166_altered_tumor_susceptibility1.98500845
32MP0008004_abnormal_stomach_pH1.94443273
33MP0003075_altered_response_to1.94026431
34MP0003724_increased_susceptibility_to1.93003788
35MP0003279_aneurysm1.92290892
36MP0004808_abnormal_hematopoietic_stem1.90496782
37MP0003705_abnormal_hypodermis_morpholog1.88242429
38MP0000716_abnormal_immune_system1.87074479
39MP0001853_heart_inflammation1.82360675
40MP0010155_abnormal_intestine_physiology1.79029991
41MP0002933_joint_inflammation1.78825399
42MP0005464_abnormal_platelet_physiology1.77906455
43MP0008438_abnormal_cutaneous_collagen1.76436741
44MP0000858_altered_metastatic_potential1.76065585
45MP0003950_abnormal_plasma_membrane1.75498321
46MP0001542_abnormal_bone_strength1.67229086
47MP0000689_abnormal_spleen_morphology1.65677696
48MP0002396_abnormal_hematopoietic_system1.65290090
49MP0001533_abnormal_skeleton_physiology1.63135278
50MP0005023_abnormal_wound_healing1.61802407
51MP0003566_abnormal_cell_adhesion1.60441552
52MP0002722_abnormal_immune_system1.60388881
53MP0003091_abnormal_cell_migration1.60279986
54MP0009278_abnormal_bone_marrow1.59062694
55MP0002139_abnormal_hepatobiliary_system1.57657457
56MP0001845_abnormal_inflammatory_respons1.55707850
57MP0003448_altered_tumor_morphology1.52844497
58MP0004510_myositis1.52159803
59MP0001873_stomach_inflammation1.51893117
60MP0002429_abnormal_blood_cell1.51811459
61MP0001545_abnormal_hematopoietic_system1.50526915
62MP0005397_hematopoietic_system_phenotyp1.50526915
63MP0005257_abnormal_intraocular_pressure1.41814727
64MP0000703_abnormal_thymus_morphology1.40761336
65MP0002254_reproductive_system_inflammat1.31947040
66MP0003172_abnormal_lysosome_physiology1.28111794
67MP0003045_fibrosis1.27499479
68MP0002998_abnormal_bone_remodeling1.25664433
69MP0005165_increased_susceptibility_to1.24742110
70MP0001958_emphysema1.24258429
71MP0002138_abnormal_hepatobiliary_system1.23558207
72MP0003866_abnormal_defecation1.19807524
73MP0003453_abnormal_keratinocyte_physiol1.17558487
74MP0000604_amyloidosis1.15942234
75MP0000733_abnormal_muscle_development1.15506761
76MP0000465_gastrointestinal_hemorrhage1.15181280
77MP0005275_abnormal_skin_tensile1.11260121
78MP0000490_abnormal_crypts_of1.08584030
79MP0003806_abnormal_nucleotide_metabolis1.07433268
80MP0008469_abnormal_protein_level1.06861684
81MP0005076_abnormal_cell_differentiation1.06268264
82MP0002877_abnormal_melanocyte_morpholog1.05573935
83MP0005390_skeleton_phenotype1.05476315
84MP0006054_spinal_hemorrhage1.04859969
85MP0009764_decreased_sensitivity_to1.03687471
86MP0000767_abnormal_smooth_muscle1.02444356
87MP0003656_abnormal_erythrocyte_physiolo0.98278381
88MP0002928_abnormal_bile_duct0.96217838
89MP0008260_abnormal_autophagy0.92514958
90MP0005167_abnormal_blood-brain_barrier0.90517292
91MP0001243_abnormal_dermal_layer0.85928752
92MP0002060_abnormal_skin_morphology0.85515078
93MP0003795_abnormal_bone_structure0.83365768
94MP0002019_abnormal_tumor_incidence0.81697393
95MP0004272_abnormal_basement_membrane0.81591304
96MP0001851_eye_inflammation0.81531863
97MP0009765_abnormal_xenobiotic_induced0.81530875
98MP0004883_abnormal_blood_vessel0.81269082
99MP0000343_altered_response_to0.80643395
100MP0000249_abnormal_blood_vessel0.79928154
101MP0001849_ear_inflammation0.79907404
102MP0003828_pulmonary_edema0.78255231
103MP0005595_abnormal_vascular_smooth0.76951661
104MP0010307_abnormal_tumor_latency0.74177944
105MP0009384_cardiac_valve_regurgitation0.73862193
106MP0004858_abnormal_nervous_system0.72862162
107MP0001663_abnormal_digestive_system0.70547857
108MP0002168_other_aberrant_phenotype0.70327780
109MP0002136_abnormal_kidney_physiology0.69600493
110MP0003191_abnormal_cellular_cholesterol0.68485880
111MP0005166_decreased_susceptibility_to0.67813665
112MP0003252_abnormal_bile_duct0.67378046
113MP0001879_abnormal_lymphatic_vessel0.67260989
114MP0005503_abnormal_tendon_morphology0.66868791
115MP0005375_adipose_tissue_phenotype0.66818870
116MP0010234_abnormal_vibrissa_follicle0.66606392
117MP0001348_abnormal_lacrimal_gland0.66190690
118MP0005623_abnormal_meninges_morphology0.65979056
119MP0005666_abnormal_adipose_tissue0.65063086
120MP0009763_increased_sensitivity_to0.64687203
121MP0001216_abnormal_epidermal_layer0.64118439
122MP0005310_abnormal_salivary_gland0.60039716
123MP0001191_abnormal_skin_condition0.58761502
124MP0010368_abnormal_lymphatic_system0.58503723
125MP0005164_abnormal_response_to0.58364328
126MP0009931_abnormal_skin_appearance0.55866833
127MP0001614_abnormal_blood_vessel0.54900138

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.82647750
2Abnormality of liposaccharide metabolism (HP:0010968)5.82647750
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.82647750
4Eczematoid dermatitis (HP:0000976)4.29058907
5Dysostosis multiplex (HP:0000943)4.06322375
6Elevated erythrocyte sedimentation rate (HP:0003565)3.92502424
7Nuclear cataract (HP:0100018)3.71804655
8Recurrent abscess formation (HP:0002722)3.62455679
9Loss of speech (HP:0002371)3.50131869
10Vacuolated lymphocytes (HP:0001922)3.44549818
11Myositis (HP:0100614)3.40856695
12Autoimmune thrombocytopenia (HP:0001973)3.34440171
13Aortic aneurysm (HP:0004942)3.31526578
14Cellulitis (HP:0100658)3.27031699
15Stomatitis (HP:0010280)3.23803712
16Recurrent fungal infections (HP:0002841)3.23388981
17Recurrent bacterial skin infections (HP:0005406)3.21502615
18Pustule (HP:0200039)3.20611958
19Abnormality of polysaccharide metabolism (HP:0011012)3.18614992
20Abnormality of glycosaminoglycan metabolism (HP:0004371)3.18614992
21Abnormality of mucopolysaccharide metabolism (HP:0011020)3.18614992
22Recurrent viral infections (HP:0004429)3.17012115
23Recurrent bronchitis (HP:0002837)3.14423161
24Mediastinal lymphadenopathy (HP:0100721)3.12226763
25Protrusio acetabuli (HP:0003179)3.05697359
26Urinary glycosaminoglycan excretion (HP:0003541)3.03537791
27Mucopolysacchariduria (HP:0008155)3.03537791
28T lymphocytopenia (HP:0005403)3.01600921
29Syringomyelia (HP:0003396)3.00478382
30Spinal cord lesions (HP:0100561)3.00478382
31Systemic lupus erythematosus (HP:0002725)2.97865300
32Abnormality of T cell number (HP:0011839)2.97392263
33Agammaglobulinemia (HP:0004432)2.95624146
34Increased density of long bones (HP:0006392)2.92765483
35Chronic otitis media (HP:0000389)2.89707792
36Interstitial pulmonary disease (HP:0006530)2.87804960
37Vasculitis (HP:0002633)2.86786826
38Emphysema (HP:0002097)2.85402429
39Increased cerebral lipofuscin (HP:0011813)2.76296619
40Dilatation of the ascending aorta (HP:0005111)2.75707535
41Keratoconjunctivitis sicca (HP:0001097)2.73029382
42Axonal loss (HP:0003447)2.73023397
43Nasal polyposis (HP:0100582)2.72272268
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.71685041
45Osteolytic defects of the hand bones (HP:0009699)2.71685041
46Gastrointestinal stroma tumor (HP:0100723)2.68723640
47Thrombocytosis (HP:0001894)2.64788345
48Cerebral aneurysm (HP:0004944)2.63570543
49Lymphopenia (HP:0001888)2.60555246
50Neurofibrillary tangles (HP:0002185)2.59720146
51Vertebral compression fractures (HP:0002953)2.59036954
52Disinhibition (HP:0000734)2.55145901
53Abnormality of cells of the lymphoid lineage (HP:0012140)2.53219289
54Panhypogammaglobulinemia (HP:0003139)2.52098957
55Abnormality of T cells (HP:0002843)2.51530091
56Orchitis (HP:0100796)2.51083068
57Meningitis (HP:0001287)2.49514192
58IgM deficiency (HP:0002850)2.48140544
59Abnormality of the nasal mucosa (HP:0000433)2.45584718
60Recurrent skin infections (HP:0001581)2.45561222
61Aortic dissection (HP:0002647)2.45062120
62Peritonitis (HP:0002586)2.44744024
63Inflammation of the large intestine (HP:0002037)2.44016888
64Recurrent cutaneous fungal infections (HP:0011370)2.43229309
65Chronic mucocutaneous candidiasis (HP:0002728)2.43229309
66Parakeratosis (HP:0001036)2.40445620
67Premature rupture of membranes (HP:0001788)2.40182531
68Amyloidosis (HP:0011034)2.38632616
69Abnormality of the fingertips (HP:0001211)2.38345952
70Abnormal delayed hypersensitivity skin test (HP:0002963)2.37563148
71Keratoconjunctivitis (HP:0001096)2.37160922
72Increased serum ferritin (HP:0003281)2.37008075
73Vascular tortuosity (HP:0004948)2.36303751
74Gastrointestinal inflammation (HP:0004386)2.35432626
75Osteomyelitis (HP:0002754)2.33928405
76Abnormal platelet volume (HP:0011876)2.31041030
77Asymmetric septal hypertrophy (HP:0001670)2.30732039
78Recurrent gram-negative bacterial infections (HP:0005420)2.29942235
79Myocardial infarction (HP:0001658)2.29505677
80Absent frontal sinuses (HP:0002688)2.27977825
81Arterial thrombosis (HP:0004420)2.26767366
82Retrobulbar optic neuritis (HP:0100654)2.24190088
83Optic neuritis (HP:0100653)2.24190088
84Pulmonary infiltrates (HP:0002113)2.24114469
85Abnormality of macrophages (HP:0004311)2.23887383
86Colitis (HP:0002583)2.19827989
87Atrophic scars (HP:0001075)2.18606530
88IgA deficiency (HP:0002720)2.18523805
89Spontaneous hematomas (HP:0007420)2.17669147
90Prolonged neonatal jaundice (HP:0006579)2.17573854
91Arterial tortuosity (HP:0005116)2.16702593
92Cerebral inclusion bodies (HP:0100314)2.16111940
93Broad face (HP:0000283)2.15416879
94Verrucae (HP:0200043)2.14363238
95Papilloma (HP:0012740)2.14363238
96Abnormality of the pericardium (HP:0001697)2.12652684
97Apathy (HP:0000741)2.12029925
98Joint stiffness (HP:0001387)2.11156889
99Persistence of primary teeth (HP:0006335)2.10469734
100Increased IgE level (HP:0003212)2.09995744
101Increased mean platelet volume (HP:0011877)2.06628393
102Hepatosplenomegaly (HP:0001433)2.06556053
103Progressive neurologic deterioration (HP:0002344)2.06361316
104Hematochezia (HP:0002573)2.06106589
105Periodontitis (HP:0000704)2.04732022
106Gangrene (HP:0100758)2.04659348
107Leukocytosis (HP:0001974)2.04154338
108Obstructive lung disease (HP:0006536)2.03773318
109Chronic obstructive pulmonary disease (HP:0006510)2.03773318
110Achilles tendon contracture (HP:0001771)2.03564950
111Distal lower limb muscle weakness (HP:0009053)2.02386708
112Skin ulcer (HP:0200042)2.01793261
113Spondylolisthesis (HP:0003302)2.01654265
114Abnormality of T cell physiology (HP:0011840)2.01440447
115Gastrointestinal infarctions (HP:0005244)2.00830028
116Diminished motivation (HP:0000745)2.00426737
117Restrictive lung disease (HP:0002091)1.99890937
118Gingivitis (HP:0000230)1.99633422
119Short nail (HP:0001799)1.97969356
120Increased neuronal autofluorescent lipopigment (HP:0002074)1.97629572
121Distal upper limb amyotrophy (HP:0007149)1.97558151
122Upper limb amyotrophy (HP:0009129)1.97558151
123Cervical subluxation (HP:0003308)1.96952345
124Thin bony cortex (HP:0002753)1.96936995
125Ulnar bowing (HP:0003031)1.96757725
126Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.95570830
127Hypergammaglobulinemia (HP:0010702)1.94859449
128Chronic diarrhea (HP:0002028)1.93689427
129IgG deficiency (HP:0004315)1.92555851
130Epistaxis (HP:0000421)1.91273036
131Increased IgM level (HP:0003496)1.90015865
132Mutism (HP:0002300)1.89361327
133J-shaped sella turcica (HP:0002680)1.88695086
134Mitral valve prolapse (HP:0001634)1.88010236
135Radial bowing (HP:0002986)1.87960366
136Prolonged bleeding time (HP:0003010)1.86595374
137Basal ganglia calcification (HP:0002135)1.86534198
138Distal lower limb amyotrophy (HP:0008944)1.85402237
139Shallow orbits (HP:0000586)1.83694191
140Combined immunodeficiency (HP:0005387)1.82774039
141Bone pain (HP:0002653)1.82764376
142Chest pain (HP:0100749)1.82479428
143Eosinophilia (HP:0001880)1.82165403
144Glomerulopathy (HP:0100820)1.80544939
145Abnormality of the Achilles tendon (HP:0005109)1.80244028
146Abnormality of the distal phalanges of the toes (HP:0010182)1.79353575
147Hypertensive crisis (HP:0100735)1.78827323
148Hyperparathyroidism (HP:0000843)1.78017488
149Aseptic necrosis (HP:0010885)1.76877191
150Purpura (HP:0000979)1.76502561
151Autoimmune hemolytic anemia (HP:0001890)1.74060757
152Fused cervical vertebrae (HP:0002949)1.74009316
153Blue sclerae (HP:0000592)1.72866663
154Hemoptysis (HP:0002105)1.72430197
155Acne (HP:0001061)1.70619729
156Neuronal loss in central nervous system (HP:0002529)1.69843987
157Anorexia (HP:0002039)1.68670406
158Ovoid vertebral bodies (HP:0003300)1.67310343
159Segmental peripheral demyelination/remyelination (HP:0003481)1.66218484
160Protuberant abdomen (HP:0001538)1.66066448
161Polyneuropathy (HP:0001271)1.64978700

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.55676776
2TAOK23.21978227
3MAP3K143.12984955
4JAK32.81145407
5TXK2.76921757
6TBK12.55028983
7STK102.54369319
8MAP3K102.49226881
9TTN2.35736969
10PRPF4B2.33940634
11ERN12.33129832
12GRK72.32102098
13ZAP702.15549764
14TYK21.99594138
15IKBKE1.92800668
16RPS6KA41.91781800
17TGFBR21.91169572
18LRRK21.90048798
19FGFR41.87585742
20IKBKB1.85261298
21ITK1.77426225
22JAK11.76444749
23LATS21.66192000
24TRIB31.63781203
25BTK1.61591907
26EEF2K1.58575881
27BLK1.58096326
28CHUK1.56683671
29NME21.54325889
30IRAK41.45653033
31PIM21.44166877
32HCK1.42578219
33CSK1.42275218
34KIT1.41733305
35RIPK41.40336198
36MAP3K131.38757858
37EPHB11.37143932
38CDC42BPA1.33915134
39PIM11.32965443
40MATK1.30671417
41TEC1.30328639
42LCK1.28791682
43GRK61.27599046
44MARK31.26111231
45FGFR31.25611524
46CSF1R1.25402481
47BMPR21.25065117
48PKN21.24743343
49SYK1.24099470
50MST41.22544121
51MAP2K31.17595234
52NLK1.16988885
53ABL21.16336191
54BMX1.12124446
55IRAK31.10549078
56TRPM71.09861426
57IRAK21.04603900
58EPHA31.03774684
59ARAF0.96132547
60SIK20.95642734
61FGR0.95560077
62CDK120.94357943
63TESK20.92589237
64MAP3K10.91970534
65EPHA20.90845874
66PTK60.88892712
67NEK90.88094595
68LYN0.86383505
69RIPK10.86091830
70PRKCH0.84917648
71SIK10.83974283
72LIMK10.83467741
73ICK0.83289567
74MAP3K30.78100974
75SIK30.78015335
76MOS0.77446236
77BRD40.77443251
78TAOK10.75191456
79LMTK20.73702286
80PDGFRB0.69020284
81PAK40.67916724
82PRKD20.67859021
83PAK20.66060054
84FLT30.65945849
85SMG10.65916258
86JAK20.65658361
87CDK60.65585176
88HIPK20.65569464
89MAP3K50.64761242
90TGFBR10.63753012
91CLK10.62423672
92DDR20.60606338
93PRKCQ0.58993348
94ABL10.58849431
95MET0.58087376
96KDR0.57233656
97MAP3K110.57061806
98INSR0.55350621
99MAP3K80.54687024
100MYLK0.53599571
101BRAF0.53363646
102RPS6KB20.51116956
103MAP3K70.50872502
104MAPKAPK20.47656779
105DYRK30.47389578
106MELK0.45322443
107ERBB40.44308914
108PDGFRA0.43873974
109PTK20.43766665
110CDK40.42702418
111RPS6KA60.40944688
112TESK10.39667135
113PAK10.38802013
114STK380.38425888
115MTOR0.37896601
116STK40.37091583
117DAPK30.35049956
118EPHB20.35001810
119GSK3A0.34969648
120DYRK1B0.34736587
121IRAK10.34663130
122EGFR0.34125787
123RPS6KA20.33852360
124ADRBK20.32851621
125TNK20.32849377
126PRKG20.31978545
127STK30.31118676
128RPS6KL10.30910152
129RPS6KC10.30910152
130IGF1R0.29944959
131CDK90.29357365
132DMPK0.29115569
133MST1R0.28313677
134PDPK10.27895449
135MAPK70.26149009
136MAPK40.23807594
137MAP2K60.22684661

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.94939365
2Graft-versus-host disease_Homo sapiens_hsa053322.87669612
3Leishmaniasis_Homo sapiens_hsa051402.82861764
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.72912201
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30502565
6B cell receptor signaling pathway_Homo sapiens_hsa046622.24487944
7Osteoclast differentiation_Homo sapiens_hsa043802.23977520
8Measles_Homo sapiens_hsa051622.23715257
9Hematopoietic cell lineage_Homo sapiens_hsa046402.15695952
10Allograft rejection_Homo sapiens_hsa053302.13604744
11Malaria_Homo sapiens_hsa051441.99795210
12T cell receptor signaling pathway_Homo sapiens_hsa046601.95253431
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.92272615
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91777429
15Antigen processing and presentation_Homo sapiens_hsa046121.90309469
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.83601272
17TNF signaling pathway_Homo sapiens_hsa046681.81117959
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77579978
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.71527519
20Toxoplasmosis_Homo sapiens_hsa051451.70155743
21Legionellosis_Homo sapiens_hsa051341.69699235
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63567858
23Viral myocarditis_Homo sapiens_hsa054161.61441858
24Shigellosis_Homo sapiens_hsa051311.61293384
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.60845448
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59147603
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.53390802
28Herpes simplex infection_Homo sapiens_hsa051681.49464245
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.47651661
30Tuberculosis_Homo sapiens_hsa051521.45157616
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45028573
32Pertussis_Homo sapiens_hsa051331.44152528
33Apoptosis_Homo sapiens_hsa042101.43336764
34Influenza A_Homo sapiens_hsa051641.38907259
35Salmonella infection_Homo sapiens_hsa051321.38791162
36Type I diabetes mellitus_Homo sapiens_hsa049401.38668438
37Chronic myeloid leukemia_Homo sapiens_hsa052201.37113733
38Prion diseases_Homo sapiens_hsa050201.36545880
39Hepatitis B_Homo sapiens_hsa051611.32391703
40Acute myeloid leukemia_Homo sapiens_hsa052211.32162718
41* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31318047
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.25287965
43Small cell lung cancer_Homo sapiens_hsa052221.24039221
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23551594
45Chemokine signaling pathway_Homo sapiens_hsa040621.20536750
46Rheumatoid arthritis_Homo sapiens_hsa053231.15025112
47Platelet activation_Homo sapiens_hsa046111.13596642
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13198426
49Asthma_Homo sapiens_hsa053101.11405077
50Pancreatic cancer_Homo sapiens_hsa052121.10796823
51African trypanosomiasis_Homo sapiens_hsa051431.07130746
52Proteoglycans in cancer_Homo sapiens_hsa052051.05979203
53HTLV-I infection_Homo sapiens_hsa051661.01039786
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99773183
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99272470
56Amoebiasis_Homo sapiens_hsa051460.98302917
57Focal adhesion_Homo sapiens_hsa045100.95284857
58Autoimmune thyroid disease_Homo sapiens_hsa053200.93183981
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92285252
60Staphylococcus aureus infection_Homo sapiens_hsa051500.91491720
61Epstein-Barr virus infection_Homo sapiens_hsa051690.89073860
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89053438
63ECM-receptor interaction_Homo sapiens_hsa045120.88665670
64Adherens junction_Homo sapiens_hsa045200.87685630
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.85344535
66Hepatitis C_Homo sapiens_hsa051600.85080380
67p53 signaling pathway_Homo sapiens_hsa041150.83981842
68MicroRNAs in cancer_Homo sapiens_hsa052060.83677873
69Sphingolipid metabolism_Homo sapiens_hsa006000.82924733
70Viral carcinogenesis_Homo sapiens_hsa052030.81624975
71Prolactin signaling pathway_Homo sapiens_hsa049170.79580502
72Galactose metabolism_Homo sapiens_hsa000520.76991843
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76314577
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68157879
75Notch signaling pathway_Homo sapiens_hsa043300.67241308
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67045569
77VEGF signaling pathway_Homo sapiens_hsa043700.62602075
78Colorectal cancer_Homo sapiens_hsa052100.62249833
79Vibrio cholerae infection_Homo sapiens_hsa051100.61893013
80Prostate cancer_Homo sapiens_hsa052150.60488373
81Phagosome_Homo sapiens_hsa041450.60356840
82Fructose and mannose metabolism_Homo sapiens_hsa000510.59372698
83Other glycan degradation_Homo sapiens_hsa005110.58181704
84FoxO signaling pathway_Homo sapiens_hsa040680.56214272
85HIF-1 signaling pathway_Homo sapiens_hsa040660.54486391
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54172865
87Complement and coagulation cascades_Homo sapiens_hsa046100.52924525
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52803651
89Non-small cell lung cancer_Homo sapiens_hsa052230.51200194
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.51186513
91Lysosome_Homo sapiens_hsa041420.51184738
92MAPK signaling pathway_Homo sapiens_hsa040100.49628937
93Sulfur metabolism_Homo sapiens_hsa009200.49356880
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49310151
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48840933
96Pathways in cancer_Homo sapiens_hsa052000.48394928
97Rap1 signaling pathway_Homo sapiens_hsa040150.47985007
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46421464
99TGF-beta signaling pathway_Homo sapiens_hsa043500.45571630
100Bladder cancer_Homo sapiens_hsa052190.44488370
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39900047
102Renal cell carcinoma_Homo sapiens_hsa052110.39693021
103Thyroid cancer_Homo sapiens_hsa052160.39494806
104Insulin resistance_Homo sapiens_hsa049310.39035592
105Endocytosis_Homo sapiens_hsa041440.38877500
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.38216891
107Type II diabetes mellitus_Homo sapiens_hsa049300.37753766
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.36128109
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36090486
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35896210
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.34418705
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30763335
113mTOR signaling pathway_Homo sapiens_hsa041500.30166293
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28942749
115Endometrial cancer_Homo sapiens_hsa052130.28106535
116Ribosome_Homo sapiens_hsa030100.26286094
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25612299

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