CLCN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)9.15440702
2actin-myosin filament sliding (GO:0033275)9.15440702
3regulation of skeletal muscle contraction (GO:0014819)9.14517176
4sarcoplasmic reticulum calcium ion transport (GO:0070296)8.54509111
5skeletal muscle contraction (GO:0003009)8.44751831
6actin-mediated cell contraction (GO:0070252)7.51077499
7skeletal muscle adaptation (GO:0043501)6.66275080
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.35684858
9skeletal muscle fiber development (GO:0048741)5.97718527
10creatine metabolic process (GO:0006600)5.86826643
11regulation of cell communication by electrical coupling (GO:0010649)5.70092177
12plasma membrane repair (GO:0001778)5.62387706
13actin filament-based movement (GO:0030048)5.55211006
14regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.47292128
15NADH metabolic process (GO:0006734)5.32949383
16response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.28783871
17myotube cell development (GO:0014904)5.27229053
18regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.19918455
19striated muscle contraction (GO:0006941)5.15353059
20fructose metabolic process (GO:0006000)4.97963052
21sarcomere organization (GO:0045214)4.91410686
22glycogen catabolic process (GO:0005980)4.88743246
23skeletal muscle tissue development (GO:0007519)4.88088731
24myofibril assembly (GO:0030239)4.68435843
25glucan catabolic process (GO:0009251)4.56261969
262-oxoglutarate metabolic process (GO:0006103)4.50869694
27cardiac muscle hypertrophy (GO:0003300)4.38772671
28response to inactivity (GO:0014854)4.31045898
29muscle organ morphogenesis (GO:0048644)4.29307530
30response to muscle activity (GO:0014850)4.28531155
31* muscle contraction (GO:0006936)4.22767849
32striated muscle hypertrophy (GO:0014897)4.19124211
33gluconeogenesis (GO:0006094)4.17773643
34positive regulation of myotube differentiation (GO:0010831)4.14635834
35negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.11949290
36cellular polysaccharide catabolic process (GO:0044247)4.10869204
37neuromuscular synaptic transmission (GO:0007274)4.05837185
38muscle cell fate commitment (GO:0042693)3.99406300
39ubiquinone biosynthetic process (GO:0006744)3.91228765
40carnitine shuttle (GO:0006853)3.89996477
41polysaccharide catabolic process (GO:0000272)3.89187361
42muscle fiber development (GO:0048747)3.82649227
43* neuronal action potential propagation (GO:0019227)3.79335592
44axon ensheathment in central nervous system (GO:0032291)3.77976365
45central nervous system myelination (GO:0022010)3.77976365
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.77217542
47regulation of calcium ion transmembrane transport (GO:1903169)3.75957319
48regulation of calcium ion transmembrane transporter activity (GO:1901019)3.75957319
49cellular carbohydrate catabolic process (GO:0044275)3.74879245
50* muscle system process (GO:0003012)3.74376060
51muscle hypertrophy (GO:0014896)3.73880553
52hexose biosynthetic process (GO:0019319)3.72686670
53regulation of acyl-CoA biosynthetic process (GO:0050812)3.72656494
54muscle tissue morphogenesis (GO:0060415)3.72555454
55myoblast fusion (GO:0007520)3.72488433
56negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.71226418
57negative regulation of calcium ion transmembrane transport (GO:1903170)3.71226418
58regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.71222662
59striated muscle adaptation (GO:0014888)3.70500423
60tricarboxylic acid cycle (GO:0006099)3.65208314
61regulation of relaxation of muscle (GO:1901077)3.63501977
62negative regulation of protein localization to cell surface (GO:2000009)3.63324058
63striated muscle atrophy (GO:0014891)3.58956396
64negative regulation of muscle contraction (GO:0045932)3.58066130
65skeletal muscle tissue regeneration (GO:0043403)3.55708882
66cytidine metabolic process (GO:0046087)3.54388642
67cytidine catabolic process (GO:0006216)3.54388642
68cytidine deamination (GO:0009972)3.54388642
69pyrimidine ribonucleoside catabolic process (GO:0046133)3.53014530
70positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.52343846
71regulation of skeletal muscle cell differentiation (GO:2001014)3.51920478
72actomyosin structure organization (GO:0031032)3.48988463
73negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.47902267
74neuromuscular junction development (GO:0007528)3.47278182
75cardiac muscle tissue morphogenesis (GO:0055008)3.47254039
76regulation of actin filament-based movement (GO:1903115)3.45906354
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43125333
78regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.41936263
79ubiquinone metabolic process (GO:0006743)3.41214185
80glycogen biosynthetic process (GO:0005978)3.37973056
81glucan biosynthetic process (GO:0009250)3.37973056
82cardiac muscle adaptation (GO:0014887)3.37178991
83cardiac muscle hypertrophy in response to stress (GO:0014898)3.37178991
84muscle hypertrophy in response to stress (GO:0003299)3.37178991
85adult heart development (GO:0007512)3.34157803
86regulation of striated muscle contraction (GO:0006942)3.33947558
87quinone biosynthetic process (GO:1901663)3.33628890
88positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.33603313
89regulation of coenzyme metabolic process (GO:0051196)3.30671328
90regulation of cofactor metabolic process (GO:0051193)3.30671328
91oxaloacetate metabolic process (GO:0006107)3.30006424
92mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28889068
93purine nucleotide salvage (GO:0032261)3.28882337
94muscle cell cellular homeostasis (GO:0046716)3.28625165
95syncytium formation by plasma membrane fusion (GO:0000768)3.25869362
96regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.25587557
97relaxation of muscle (GO:0090075)3.25101941
98muscle cell development (GO:0055001)3.23739576
99striated muscle tissue development (GO:0014706)3.23681171
100regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.18729866
101respiratory electron transport chain (GO:0022904)3.18445868
102muscle atrophy (GO:0014889)3.17694621
103heart process (GO:0003015)3.16899111
104heart contraction (GO:0060047)3.16899111
105cellular polysaccharide metabolic process (GO:0044264)3.16783919
106negative regulation of potassium ion transmembrane transport (GO:1901380)3.16117546
107muscle structure development (GO:0061061)3.15696173
108cardiac muscle contraction (GO:0060048)3.15678482
109membrane depolarization during action potential (GO:0086010)3.14477609
110muscle organ development (GO:0007517)3.13720646
111substantia nigra development (GO:0021762)3.10353764
112fatty acid transmembrane transport (GO:1902001)3.08979846
113negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.08691033
114electron transport chain (GO:0022900)3.08186244
115regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.07232851
116negative regulation of skeletal muscle tissue development (GO:0048642)3.05290746
117ATP synthesis coupled proton transport (GO:0015986)2.98869096
118energy coupled proton transport, down electrochemical gradient (GO:0015985)2.98869096
119positive regulation of cation channel activity (GO:2001259)2.96828385
120negative regulation of muscle hypertrophy (GO:0014741)2.96052755
121regulation of cation channel activity (GO:2001257)2.91889013
122muscle adaptation (GO:0043500)2.90360261
123cerebellar granule cell differentiation (GO:0021707)2.90088255
124neuron cell-cell adhesion (GO:0007158)2.89583110
125regulation of membrane repolarization (GO:0060306)2.89372282
126glycogen metabolic process (GO:0005977)2.87090756
127myotube differentiation (GO:0014902)2.84189637
128carnitine transmembrane transport (GO:1902603)2.83554868
129striated muscle cell development (GO:0055002)2.83244232
130glucan metabolic process (GO:0044042)2.80831306
131cellular glucan metabolic process (GO:0006073)2.80831306
132positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.76879008
133calcium ion import (GO:0070509)2.76433570
134response to activity (GO:0014823)2.76268216
135establishment of mitochondrion localization (GO:0051654)2.73945433
136IMP metabolic process (GO:0046040)2.73383534
137cardiac myofibril assembly (GO:0055003)2.69587718

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.56335906
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.92395005
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.30549024
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.06164739
5GBX2_23144817_ChIP-Seq_PC3_Human2.84893245
6BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.65497826
7AR_21572438_ChIP-Seq_LNCaP_Human2.50057261
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46945264
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46586560
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.45580311
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42346511
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34253957
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.33460484
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.24436360
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19993995
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19993995
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08729065
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07705704
19VDR_22108803_ChIP-Seq_LS180_Human2.06564310
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.05517131
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04604026
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.03644679
23ZNF274_21170338_ChIP-Seq_K562_Hela2.01648305
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99258576
25DROSHA_22980978_ChIP-Seq_HELA_Human1.96496856
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95807380
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94230611
28TAF15_26573619_Chip-Seq_HEK293_Human1.89844198
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87437370
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86497877
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.81272402
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79587895
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79497439
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.78726431
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.78631456
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.72771480
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70670782
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69657527
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.68469889
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67719332
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.64875209
42GATA1_22025678_ChIP-Seq_K562_Human1.63809757
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.62610671
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50780806
45ER_23166858_ChIP-Seq_MCF-7_Human1.49186240
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47704801
47FUS_26573619_Chip-Seq_HEK293_Human1.44291797
48SA1_27219007_Chip-Seq_Bcells_Human1.43855442
49ZNF263_19887448_ChIP-Seq_K562_Human1.43004811
50REST_21632747_ChIP-Seq_MESCs_Mouse1.40971977
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40638159
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40546399
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40162591
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38884740
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37205953
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.36913645
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.35796562
58STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.35687943
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33847715
60GATA4_21415370_ChIP-Seq_HL-1_Mouse1.33237449
61CTCF_21964334_ChIP-Seq_BJAB-B_Human1.32661350
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31829263
63NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.31510518
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30570806
65SPI1_20517297_ChIP-Seq_HL60_Human1.30369463
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28613601
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28298648
68OCT4_20526341_ChIP-Seq_ESCs_Human1.27436612
69RXR_22158963_ChIP-Seq_LIVER_Mouse1.27329790
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26190951
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26127622
72SMC3_22415368_ChIP-Seq_MEFs_Mouse1.25498019
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23958370
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.23319178
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.22889202
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22317195
77STAT1_20625510_ChIP-Seq_HELA_Human1.19402611
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19092490
79SMAD4_21799915_ChIP-Seq_A2780_Human1.18908616
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16841956
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16112473
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.15233834
83GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13900111
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.13699219
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13462394
86MYC_27129775_Chip-Seq_CORNEA_Mouse1.12846458
87P300_19829295_ChIP-Seq_ESCs_Human1.12830272
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12688315
89CTCF_27219007_Chip-Seq_Bcells_Human1.12171900
90CTCF_26484167_Chip-Seq_Bcells_Mouse1.11816380
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11430204
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11218132
93NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10475747
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09561092
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.07383892
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06240378
97CTCF_21964334_Chip-Seq_Bcells_Human1.05720439
98AR_25329375_ChIP-Seq_VCAP_Human1.05675267
99LXR_22158963_ChIP-Seq_LIVER_Mouse1.05209956
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04452348
101NANOG_20526341_ChIP-Seq_ESCs_Human1.04296792
102YY1_22570637_ChIP-Seq_MALME-3M_Human1.03879003
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03380792
104RAD21_21589869_ChIP-Seq_MESCs_Mouse1.02948929
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00860965
106NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99610622
107CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99081044
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98285337
109CBP_20019798_ChIP-Seq_JUKART_Human0.98285337
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98258194
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96594306
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96470683
113STAT3_23295773_ChIP-Seq_U87_Human0.96009719
114* LXR_22292898_ChIP-Seq_THP-1_Human0.95176694
115DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94962903
116SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93392812
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93375490
118TCF7_22412390_ChIP-Seq_EML_Mouse0.93339199
119SMAD4_21741376_ChIP-Seq_EPCs_Human0.93290751
120TCF4_23295773_ChIP-Seq_U87_Human0.92579064
121CRX_20693478_ChIP-Seq_RETINA_Mouse0.92457713
122GATA3_21867929_ChIP-Seq_CD8_Mouse0.91839805
123IGF1R_20145208_ChIP-Seq_DFB_Human0.91236526
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90673920
125AR_19668381_ChIP-Seq_PC3_Human0.90593031
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88401556
127* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87729675
128* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87729675
129* TBX20_22328084_ChIP-Seq_HEART_Mouse0.87721002
130* TBX20_22080862_ChIP-Seq_HEART_Mouse0.87721002
131KDM2B_26808549_Chip-Seq_DND41_Human0.87410346
132TDRD3_21172665_ChIP-Seq_MCF-7_Human0.87219791
133GATA6_21074721_ChIP-Seq_CACO-2_Human0.86985413
134RING1B_27294783_Chip-Seq_ESCs_Mouse0.86436893
135TP53_20018659_ChIP-ChIP_R1E_Mouse0.85709022
136RNF2_27304074_Chip-Seq_NSC_Mouse0.85551386
137ARNT_22903824_ChIP-Seq_MCF-7_Human0.85391799
138FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85058786
139WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83742242
140WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83329049
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.82989485
142STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82449950
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.80019569
144CEBPB_22108803_ChIP-Seq_LS180_Human0.79434368
145MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.79242016
146OCT1_27270436_Chip-Seq_PROSTATE_Human0.79230427
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.79204121
148SUZ12_27294783_Chip-Seq_NPCs_Mouse0.78881180
149SA1_27219007_Chip-Seq_ERYTHROID_Human0.78843113
150P53_21459846_ChIP-Seq_SAOS-2_Human0.78776991
151MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78503398
152RING1B_27294783_Chip-Seq_NPCs_Mouse0.78465388
153TP53_18474530_ChIP-ChIP_U2OS_Human0.78322528
154* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.78033422
155MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.77991968
156BCAT_22108803_ChIP-Seq_LS180_Human0.77973231
157DPY_21335234_ChIP-Seq_ESCs_Mouse0.76948653
158MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.76850095
159SMC1_22415368_ChIP-Seq_MEFs_Mouse0.76710325
160ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.76420050
161CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.75696669
162OCT4_21477851_ChIP-Seq_ESCs_Mouse0.74614271
163PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.73585391
164P68_20966046_ChIP-Seq_HELA_Human0.72850071
165* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.72628633
166EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71592868
167CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.70889859
168EZH2_27294783_Chip-Seq_NPCs_Mouse0.70458406
169OCT4_19829295_ChIP-Seq_ESCs_Human0.70238617
170E2F1_20622854_ChIP-Seq_HELA_Human0.69914387
171GATA1_19941827_ChIP-Seq_MEL86_Mouse0.69494942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004145_abnormal_muscle_electrophysio6.35108919
2MP0000749_muscle_degeneration5.38971732
3MP0003646_muscle_fatigue5.29051647
4MP0000751_myopathy5.23980711
5MP0000747_muscle_weakness3.88461733
6MP0005451_abnormal_body_composition3.85342078
7* MP0002106_abnormal_muscle_physiology3.52034483
8MP0002837_dystrophic_cardiac_calcinosis3.50993773
9* MP0000759_abnormal_skeletal_muscle3.21326371
10* MP0004036_abnormal_muscle_relaxation3.17573097
11* MP0005369_muscle_phenotype2.98841923
12MP0004270_analgesia2.91409545
13MP0002269_muscular_atrophy2.89446777
14MP0004087_abnormal_muscle_fiber2.78406967
15* MP0005620_abnormal_muscle_contractility2.71028577
16MP0004130_abnormal_muscle_cell2.58479632
17MP0000750_abnormal_muscle_regeneration2.49074316
18MP0004233_abnormal_muscle_weight2.24159249
19MP0003880_abnormal_central_pattern2.21524992
20MP0004859_abnormal_synaptic_plasticity2.14658128
21MP0002332_abnormal_exercise_endurance2.06919948
22MP0002108_abnormal_muscle_morphology1.75100237
23MP0000733_abnormal_muscle_development1.73006557
24MP0005330_cardiomyopathy1.66203006
25MP0003950_abnormal_plasma_membrane1.62683128
26MP0004215_abnormal_myocardial_fiber1.56152925
27MP0003635_abnormal_synaptic_transmissio1.53196211
28MP0006036_abnormal_mitochondrial_physio1.53013051
29MP0004484_altered_response_of1.41832795
30MP0004142_abnormal_muscle_tone1.40473064
31MP0009046_muscle_twitch1.40302782
32MP0004084_abnormal_cardiac_muscle1.39582509
33MP0002272_abnormal_nervous_system1.37495833
34MP0004185_abnormal_adipocyte_glucose1.36206500
35MP0002127_abnormal_cardiovascular_syste1.34043258
36MP0002734_abnormal_mechanical_nocicepti1.33741984
37MP0009745_abnormal_behavioral_response1.32284974
38MP0002064_seizures1.31227907
39MP0001440_abnormal_grooming_behavior1.29725935
40MP0008569_lethality_at_weaning1.27903058
41MP0000920_abnormal_myelination1.24798108
42MP0002972_abnormal_cardiac_muscle1.23529619
43MP0004510_myositis1.18140514
44MP0004134_abnormal_chest_morphology1.13657619
45MP0003137_abnormal_impulse_conducting1.13284648
46MP0002063_abnormal_learning/memory/cond1.12918768
47MP0001486_abnormal_startle_reflex1.11394587
48MP0001529_abnormal_vocalization1.07770958
49MP0004043_abnormal_pH_regulation1.07437654
50* MP0002067_abnormal_sensory_capabilities1.07104261
51MP0002971_abnormal_brown_adipose1.05346069
52MP0006035_abnormal_mitochondrial_morpho1.02950117
53MP0003221_abnormal_cardiomyocyte_apopto0.99012468
54MP0001299_abnormal_eye_distance/0.98570723
55MP0002572_abnormal_emotion/affect_behav0.96987812
56MP0005666_abnormal_adipose_tissue0.96035740
57MP0005670_abnormal_white_adipose0.93195444
58* MP0002066_abnormal_motor_capabilities/c0.92745601
59MP0001905_abnormal_dopamine_level0.91722994
60MP0002822_catalepsy0.90383058
61MP0000778_abnormal_nervous_system0.90156843
62MP0003806_abnormal_nucleotide_metabolis0.89635362
63MP0005266_abnormal_metabolism0.87763292
64MP0005423_abnormal_somatic_nervous0.85987992
65MP0004147_increased_porphyrin_level0.85552849
66MP0002184_abnormal_innervation0.84982884
67MP0003329_amyloid_beta_deposits0.84268149
68MP0004924_abnormal_behavior0.83810348
69MP0005386_behavior/neurological_phenoty0.83810348
70MP0006276_abnormal_autonomic_nervous0.83781967
71MP0001661_extended_life_span0.82705750
72MP0010630_abnormal_cardiac_muscle0.81341772
73MP0005375_adipose_tissue_phenotype0.80753888
74MP0000955_abnormal_spinal_cord0.80701521
75MP0009250_abnormal_appendicular_skeleto0.79945824
76MP0000013_abnormal_adipose_tissue0.78176177
77MP0001968_abnormal_touch/_nociception0.76713510
78MP0002882_abnormal_neuron_morphology0.73024172
79MP0004742_abnormal_vestibular_system0.72025961
80MP0003879_abnormal_hair_cell0.71278522
81MP0003045_fibrosis0.69985216
82MP0000762_abnormal_tongue_morphology0.69774068
83MP0004085_abnormal_heartbeat0.69735834
84MP0001544_abnormal_cardiovascular_syste0.69577957
85MP0005385_cardiovascular_system_phenoty0.69577957
86MP0002234_abnormal_pharynx_morphology0.65735366
87MP0001485_abnormal_pinna_reflex0.64738798
88MP0001970_abnormal_pain_threshold0.64212339
89MP0001501_abnormal_sleep_pattern0.64067465
90MP0003656_abnormal_erythrocyte_physiolo0.63143099
91MP0003828_pulmonary_edema0.62827789
92MP0002733_abnormal_thermal_nociception0.62620627
93* MP0002229_neurodegeneration0.62098870
94MP0000372_irregular_coat_pigmentation0.59123109
95MP0002735_abnormal_chemical_nociception0.58674327
96MP0009780_abnormal_chondrocyte_physiolo0.58424407
97MP0005083_abnormal_biliary_tract0.58287674
98MP0003633_abnormal_nervous_system0.58007045
99MP0000266_abnormal_heart_morphology0.57949637
100MP0002752_abnormal_somatic_nervous0.57600108
101MP0002557_abnormal_social/conspecific_i0.57034242
102MP0000003_abnormal_adipose_tissue0.56361661
103MP0002078_abnormal_glucose_homeostasis0.54852558
104MP0003195_calcinosis0.54254102
105MP0001943_abnormal_respiration0.53706689
106MP0005166_decreased_susceptibility_to0.52982319
107MP0003631_nervous_system_phenotype0.52663799
108MP0003634_abnormal_glial_cell0.52190320
109MP0006138_congestive_heart_failure0.51697591
110MP0005376_homeostasis/metabolism_phenot0.51662804
111MP0003690_abnormal_glial_cell0.50836502
112MP0005452_abnormal_adipose_tissue0.50201324
113MP0008775_abnormal_heart_ventricle0.49349391
114MP0002736_abnormal_nociception_after0.48669770
115MP0005535_abnormal_body_temperature0.47862646
116MP0005584_abnormal_enzyme/coenzyme_acti0.46854004
117MP0009672_abnormal_birth_weight0.44563202
118MP0005167_abnormal_blood-brain_barrier0.43359895
119MP0005319_abnormal_enzyme/_coenzyme0.42030046
120MP0005645_abnormal_hypothalamus_physiol0.39976434
121MP0005332_abnormal_amino_acid0.33369800
122MP0002128_abnormal_blood_circulation0.33322477
123MP0001346_abnormal_lacrimal_gland0.32428474
124MP0000230_abnormal_systemic_arterial0.31571373
125MP0005334_abnormal_fat_pad0.31354989
126MP0002896_abnormal_bone_mineralization0.30550302
127MP0002638_abnormal_pupillary_reflex0.30345911
128MP0002876_abnormal_thyroid_physiology0.29617949
129* MP0002114_abnormal_axial_skeleton0.28817314
130MP0005165_increased_susceptibility_to0.25204042
131MP0003948_abnormal_gas_homeostasis0.22481209
132MP0010030_abnormal_orbit_morphology0.21943277
133MP0002249_abnormal_larynx_morphology0.20071579
134MP0000343_altered_response_to0.18928015
135MP0003959_abnormal_lean_body0.17624951
136MP0003075_altered_response_to0.17156661
137MP0002118_abnormal_lipid_homeostasis0.16929730
138MP0000249_abnormal_blood_vessel0.16282533
139MP0000678_abnormal_parathyroid_gland0.15584444

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.17284212
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.69864080
3Exercise-induced myalgia (HP:0003738)8.32244968
4Nemaline bodies (HP:0003798)8.24692982
5Exercise-induced muscle cramps (HP:0003710)7.28781351
6Distal arthrogryposis (HP:0005684)6.34856890
7Type 1 muscle fiber predominance (HP:0003803)6.33425248
8Calf muscle hypertrophy (HP:0008981)6.31753698
9* Muscle hypertrophy of the lower extremities (HP:0008968)6.31753698
10Myopathic facies (HP:0002058)5.95976949
11Round ear (HP:0100830)5.77298068
12Difficulty running (HP:0009046)5.45208890
13Muscle fiber splitting (HP:0003555)5.01196263
14Ulnar deviation of the wrist (HP:0003049)4.86795275
15Myoglobinuria (HP:0002913)4.58862037
16Calcaneovalgus deformity (HP:0001848)4.50409272
17Hyporeflexia of lower limbs (HP:0002600)4.49671722
18EMG: myopathic abnormalities (HP:0003458)4.40178661
19Absent phalangeal crease (HP:0006109)4.27172563
20Abnormality of the calf musculature (HP:0001430)4.19832642
21Deformed tarsal bones (HP:0008119)4.04744922
22* Muscle stiffness (HP:0003552)4.03591816
23Rhabdomyolysis (HP:0003201)3.72312981
24Abnormal finger flexion creases (HP:0006143)3.62957180
25Increased connective tissue (HP:0009025)3.51074441
26Abnormality of skeletal muscle fiber size (HP:0012084)3.50190482
27Neck muscle weakness (HP:0000467)3.37828083
28* Myotonia (HP:0002486)3.35435766
29Rimmed vacuoles (HP:0003805)3.35270820
30Increased variability in muscle fiber diameter (HP:0003557)3.26489530
31Subaortic stenosis (HP:0001682)3.26055012
32Abnormality of the left ventricular outflow tract (HP:0011103)3.26055012
33Shoulder girdle muscle weakness (HP:0003547)3.18000860
34Difficulty climbing stairs (HP:0003551)2.98599954
35Malignant hyperthermia (HP:0002047)2.94446123
36Abnormality of the hip-girdle musculature (HP:0001445)2.93504833
37Abnormality of the musculature of the pelvis (HP:0001469)2.93504833
38Hyperkalemia (HP:0002153)2.91325392
39Sudden death (HP:0001699)2.90050382
40Pelvic girdle muscle weakness (HP:0003749)2.85937860
41Bundle branch block (HP:0011710)2.75293318
42Areflexia of lower limbs (HP:0002522)2.74864706
43Paralysis (HP:0003470)2.65413601
44Focal motor seizures (HP:0011153)2.55708706
45Frequent falls (HP:0002359)2.50768562
46Nonprogressive disorder (HP:0003680)2.39291341
47Abnormality of the calcaneus (HP:0008364)2.38929799
48Slender build (HP:0001533)2.37433328
49Dilated cardiomyopathy (HP:0001644)2.33134038
50Asymmetric septal hypertrophy (HP:0001670)2.32184593
51Muscular dystrophy (HP:0003560)2.30612832
52Fatigable weakness (HP:0003473)2.21592098
53Abnormality of the neuromuscular junction (HP:0003398)2.21592098
54Ventricular tachycardia (HP:0004756)2.20693139
55Distal lower limb amyotrophy (HP:0008944)2.20613872
56EMG: neuropathic changes (HP:0003445)2.19011355
57Broad-based gait (HP:0002136)2.18361060
58Gowers sign (HP:0003391)2.16999293
59Limb-girdle muscle weakness (HP:0003325)2.16270321
60Abnormality of the shoulder girdle musculature (HP:0001435)2.11481899
61Hip contracture (HP:0003273)2.10970696
62Proximal amyotrophy (HP:0007126)2.10546805
63Fetal akinesia sequence (HP:0001989)2.09861216
64Hypoplastic ischia (HP:0003175)2.06390701
65Bulbar palsy (HP:0001283)2.03770981
66Acute necrotizing encephalopathy (HP:0006965)1.96743434
67Lipoatrophy (HP:0100578)1.96738556
68Distal lower limb muscle weakness (HP:0009053)1.96640545
69Scapular winging (HP:0003691)1.95975511
70Generalized muscle weakness (HP:0003324)1.95225404
71Centrally nucleated skeletal muscle fibers (HP:0003687)1.93275035
72Ragged-red muscle fibers (HP:0003200)1.91649483
73Atonic seizures (HP:0010819)1.89979498
74Achilles tendon contracture (HP:0001771)1.89042471
75Heart block (HP:0012722)1.88437734
76Stridor (HP:0010307)1.86064957
77Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86046292
78Degeneration of the lateral corticospinal tracts (HP:0002314)1.84897702
79Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.84897702
80Abnormal mitochondria in muscle tissue (HP:0008316)1.84369881
81Increased intramyocellular lipid droplets (HP:0012240)1.81004859
82Abnormality of the ischium (HP:0003174)1.78922720
83Weak cry (HP:0001612)1.78729752
84Mildly elevated creatine phosphokinase (HP:0008180)1.78410280
85Abnormal atrioventricular conduction (HP:0005150)1.75728700
86Exercise intolerance (HP:0003546)1.74315532
87Pheochromocytoma (HP:0002666)1.73689518
88Respiratory insufficiency due to muscle weakness (HP:0002747)1.73605621
89Lower limb amyotrophy (HP:0007210)1.73532072
90Ulnar deviation of finger (HP:0009465)1.73235626
91Limb-girdle muscle atrophy (HP:0003797)1.73002986
92Progressive muscle weakness (HP:0003323)1.71023092
93Foot dorsiflexor weakness (HP:0009027)1.70870301
94Long clavicles (HP:0000890)1.66553394
95Abnormality of the Achilles tendon (HP:0005109)1.65720965
96Increased muscle lipid content (HP:0009058)1.64425822
97Progressive macrocephaly (HP:0004481)1.63792864
98Absence seizures (HP:0002121)1.62939267
99Popliteal pterygium (HP:0009756)1.62546820
100Metatarsus adductus (HP:0001840)1.61344491
101Bowel incontinence (HP:0002607)1.60898858
102Abnormality of the foot musculature (HP:0001436)1.60287228
103Acute encephalopathy (HP:0006846)1.60043259
104Urinary urgency (HP:0000012)1.59738774
105Spinal rigidity (HP:0003306)1.59308102
106Type 2 muscle fiber atrophy (HP:0003554)1.58368616
107Waddling gait (HP:0002515)1.58104597
108Cholelithiasis (HP:0001081)1.56558856
109Neuroendocrine neoplasm (HP:0100634)1.54910882
110Mitochondrial inheritance (HP:0001427)1.54402413
111Ventricular arrhythmia (HP:0004308)1.53832625
112Facial diplegia (HP:0001349)1.53580715
113Ankle clonus (HP:0011448)1.51726011
114Abnormality of the corticospinal tract (HP:0002492)1.51452017
115Muscle fiber atrophy (HP:0100295)1.48685400
116Amniotic constriction ring (HP:0009775)1.42055955
117Abnormality of placental membranes (HP:0011409)1.42055955
118Oligomenorrhea (HP:0000876)1.35297770
119Limited hip movement (HP:0008800)1.33174728
120Abnormality of potassium homeostasis (HP:0011042)1.32271798
121Dysmetric saccades (HP:0000641)1.29872245
122Cerebral palsy (HP:0100021)1.24889565
123Congenital hip dislocation (HP:0001374)1.23712946

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.51063479
2TTN5.24379844
3PHKG25.16511017
4PHKG15.16511017
5NME14.20064787
6PIK3CG2.61206429
7STK392.04792780
8MAP2K42.04603951
9PINK12.03449052
10CASK1.95149459
11PNCK1.91533146
12DMPK1.82518513
13MAP3K71.77442543
14MAPK121.65216420
15PIK3CA1.55696212
16MAP3K41.55553178
17OXSR11.54522707
18MAP2K31.49462783
19MUSK1.47361655
20PKN11.41963642
21EPHB11.37518224
22PDK31.36706425
23PDK41.36706425
24MAPKAPK31.27927369
25PAK61.12373548
26BCKDK1.10190058
27NTRK31.08848933
28TNIK1.06320740
29CDK191.05324288
30PRPF4B1.04136080
31NEK11.03245366
32MAPK131.00844653
33CAMK2G0.94689435
34MARK10.94284161
35PDK20.93442974
36MAP2K70.82168442
37MOS0.82133365
38MAP2K60.79443543
39DYRK1B0.77742328
40CAMK2B0.76242618
41CAMK2D0.75915693
42WNK10.74651306
43EEF2K0.74179561
44ROCK20.74087905
45CCNB10.73470975
46LIMK10.73069447
47CAMK2A0.71599527
48EPHA40.70662153
49FGR0.70279098
50UHMK10.66230652
51PRKAA20.65171641
52MAPKAPK50.60197128
53TRIB30.57634073
54PRKAA10.56213572
55SGK10.54697541
56KSR20.53364460
57ICK0.53294762
58CAMK40.52207406
59NTRK10.51223118
60BCR0.51176855
61MAP3K60.50869504
62CDK50.50623735
63PRKG10.50254965
64MAP3K90.49994783
65WNK40.49833034
66SGK30.46442970
67PTK2B0.46332274
68GRK70.44264990
69TBK10.43326788
70MAP3K130.43000749
71PAK30.42273587
72PRKACB0.41844878
73MINK10.41761125
74PLK20.41747549
75PRKACA0.41348080
76TRPM70.41043274
77MAP2K10.40905014
78CAMK1G0.39884212
79GRK50.38626632
80RIPK40.36567453
81RPS6KB20.35969387
82TLK10.35604780
83RIPK10.35428294
84NEK90.35346911
85RPS6KA30.35273319
86TIE10.35230464
87PRKD10.34194377
88PDPK10.33950932
89CDK140.33793143
90SGK2230.32697473
91SGK4940.32697473
92SGK20.31702701
93AKT20.31267995
94KSR10.30768294
95STK110.30392095
96TAOK20.29572869
97ILK0.29046092
98CDK150.28021288
99TYRO30.27699306
100RPS6KB10.27426434
101PRKCG0.27262268
102NTRK20.26821601
103ROCK10.25688728
104TNK20.25499090
105CDK180.25416121
106KIT0.24943635
107MAP3K110.24559210
108MAP3K120.24117932
109PRKCQ0.23685190
110RPS6KL10.23640633
111RPS6KC10.23640633
112DAPK20.23097412
113RPS6KA10.22892754
114ERBB30.22353261
115CDK11A0.22120014
116SIK10.22025598
117MAPK110.21972062
118MAPK70.21663083
119RPS6KA60.21477726
120MAP3K10.21147354
121MAPK100.21017159
122ZAP700.20954200
123FES0.20719611
124LATS20.20623242
125PDK10.19556849
126CSNK1G20.18805685
127MAPK40.17790295
128CAMK10.17731372
129PRKACG0.13584676
130ABL20.11249693
131IRAK10.10321176
132MARK30.10072883
133TAOK10.09973662
134RPS6KA20.08230581
135MAP2K20.07985666
136MAP3K30.07621634
137MTOR0.05754901
138PAK10.03971368
139MAPK30.03825414
140CSNK1D0.03082682
141PRKG20.02929379
142MARK20.02694014

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042603.78549381
2Oxidative phosphorylation_Homo sapiens_hsa001903.08517374
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.04455208
4Parkinsons disease_Homo sapiens_hsa050122.79393676
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.70888012
6Dilated cardiomyopathy_Homo sapiens_hsa054142.69264685
7Alzheimers disease_Homo sapiens_hsa050102.67871796
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.38302903
9Oxytocin signaling pathway_Homo sapiens_hsa049212.35711057
10Pentose phosphate pathway_Homo sapiens_hsa000302.20012433
11Arginine biosynthesis_Homo sapiens_hsa002202.15976086
12Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.03459764
13Calcium signaling pathway_Homo sapiens_hsa040202.02481489
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87212204
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79465652
16Nicotine addiction_Homo sapiens_hsa050331.72331886
17Long-term depression_Homo sapiens_hsa047301.66149518
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64360238
19Gastric acid secretion_Homo sapiens_hsa049711.62561628
20Propanoate metabolism_Homo sapiens_hsa006401.61279544
21Huntingtons disease_Homo sapiens_hsa050161.57383288
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55678732
23GABAergic synapse_Homo sapiens_hsa047271.54437965
24Fatty acid elongation_Homo sapiens_hsa000621.53775119
25Circadian entrainment_Homo sapiens_hsa047131.51471911
26Circadian rhythm_Homo sapiens_hsa047101.51251686
27Renin secretion_Homo sapiens_hsa049241.50466337
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49429475
29Long-term potentiation_Homo sapiens_hsa047201.49241093
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45262025
31Glucagon signaling pathway_Homo sapiens_hsa049221.41662758
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.37654161
33Fatty acid degradation_Homo sapiens_hsa000711.35972069
34Glutamatergic synapse_Homo sapiens_hsa047241.34957813
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.33264396
36Serotonergic synapse_Homo sapiens_hsa047261.31442417
37Insulin signaling pathway_Homo sapiens_hsa049101.29074566
38Salivary secretion_Homo sapiens_hsa049701.28269114
39Starch and sucrose metabolism_Homo sapiens_hsa005001.26933273
40GnRH signaling pathway_Homo sapiens_hsa049121.26353182
41Morphine addiction_Homo sapiens_hsa050321.21765150
42Phenylalanine metabolism_Homo sapiens_hsa003601.21100499
43Tight junction_Homo sapiens_hsa045301.16997596
44Cholinergic synapse_Homo sapiens_hsa047251.14531738
45Dopaminergic synapse_Homo sapiens_hsa047281.12532330
46Insulin secretion_Homo sapiens_hsa049111.12039651
47Nitrogen metabolism_Homo sapiens_hsa009101.02386358
48AMPK signaling pathway_Homo sapiens_hsa041521.00276072
49Olfactory transduction_Homo sapiens_hsa047400.99637684
50Pyruvate metabolism_Homo sapiens_hsa006200.98012420
51Amphetamine addiction_Homo sapiens_hsa050310.97800909
52Carbon metabolism_Homo sapiens_hsa012000.96543109
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95248926
54Arginine and proline metabolism_Homo sapiens_hsa003300.92378426
55Axon guidance_Homo sapiens_hsa043600.91713332
56Synaptic vesicle cycle_Homo sapiens_hsa047210.89720692
57Galactose metabolism_Homo sapiens_hsa000520.88134813
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88043537
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87431162
60Gap junction_Homo sapiens_hsa045400.86513479
61Taste transduction_Homo sapiens_hsa047420.84457342
62MAPK signaling pathway_Homo sapiens_hsa040100.83118033
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.80730836
64Renal cell carcinoma_Homo sapiens_hsa052110.80380843
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77777781
66Insulin resistance_Homo sapiens_hsa049310.76394389
67Ether lipid metabolism_Homo sapiens_hsa005650.72371441
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70998510
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69685818
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69181480
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68770950
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67799062
73Collecting duct acid secretion_Homo sapiens_hsa049660.66224789
74cAMP signaling pathway_Homo sapiens_hsa040240.65547526
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65446874
76Pancreatic secretion_Homo sapiens_hsa049720.64260718
77Melanogenesis_Homo sapiens_hsa049160.64135569
78Butanoate metabolism_Homo sapiens_hsa006500.63998336
79VEGF signaling pathway_Homo sapiens_hsa043700.61924417
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61303352
81Peroxisome_Homo sapiens_hsa041460.59282830
82Type II diabetes mellitus_Homo sapiens_hsa049300.59243152
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56158117
84Viral myocarditis_Homo sapiens_hsa054160.54138776
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52829323
86Histidine metabolism_Homo sapiens_hsa003400.51768807
87Dorso-ventral axis formation_Homo sapiens_hsa043200.51313459
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49993504
89ErbB signaling pathway_Homo sapiens_hsa040120.49639733
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47843842
91Phototransduction_Homo sapiens_hsa047440.47459824
92Fatty acid metabolism_Homo sapiens_hsa012120.46724018
93Tryptophan metabolism_Homo sapiens_hsa003800.46514792
94Focal adhesion_Homo sapiens_hsa045100.46063992
95PPAR signaling pathway_Homo sapiens_hsa033200.44447039
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43678265
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43624843
98beta-Alanine metabolism_Homo sapiens_hsa004100.43502957
99Fructose and mannose metabolism_Homo sapiens_hsa000510.41704305
100Fatty acid biosynthesis_Homo sapiens_hsa000610.41436557
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40500361
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38937932
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.38486109
104Biosynthesis of amino acids_Homo sapiens_hsa012300.38276273
105Choline metabolism in cancer_Homo sapiens_hsa052310.38098905
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36546441
107Tyrosine metabolism_Homo sapiens_hsa003500.35910055
108Steroid biosynthesis_Homo sapiens_hsa001000.35662719
109FoxO signaling pathway_Homo sapiens_hsa040680.35112851
110Ras signaling pathway_Homo sapiens_hsa040140.34659743
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33356966
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.31620550
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31434031
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.31187570
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30939861
116Cocaine addiction_Homo sapiens_hsa050300.30551345
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30092785
118Platelet activation_Homo sapiens_hsa046110.29783342
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27640086
120Sulfur relay system_Homo sapiens_hsa041220.25917893
121Amoebiasis_Homo sapiens_hsa051460.20841049
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20542740
123Regulation of autophagy_Homo sapiens_hsa041400.19816577
124Purine metabolism_Homo sapiens_hsa002300.17358920
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.15821924
126HIF-1 signaling pathway_Homo sapiens_hsa040660.14289520
127Lysine degradation_Homo sapiens_hsa003100.13772897
128Metabolic pathways_Homo sapiens_hsa011000.13218334
129Legionellosis_Homo sapiens_hsa051340.11150240
130mTOR signaling pathway_Homo sapiens_hsa041500.10409129
131Bile secretion_Homo sapiens_hsa049760.09871181
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.05732910
133ABC transporters_Homo sapiens_hsa020100.02496278
134Pertussis_Homo sapiens_hsa051330.00436126

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