CLCN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.62331031
2L-phenylalanine catabolic process (GO:0006559)5.48836408
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.48836408
4L-phenylalanine metabolic process (GO:0006558)5.20773349
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.20773349
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.14048301
7aromatic amino acid family catabolic process (GO:0009074)4.67836405
8alpha-linolenic acid metabolic process (GO:0036109)4.40694635
9sulfur amino acid catabolic process (GO:0000098)4.40619175
10high-density lipoprotein particle remodeling (GO:0034375)4.36292937
11reverse cholesterol transport (GO:0043691)4.20964779
12bile acid biosynthetic process (GO:0006699)4.16669723
13kynurenine metabolic process (GO:0070189)4.09201783
14indole-containing compound catabolic process (GO:0042436)4.05454639
15indolalkylamine catabolic process (GO:0046218)4.05454639
16tryptophan catabolic process (GO:0006569)4.05454639
17drug catabolic process (GO:0042737)4.02866611
18urea cycle (GO:0000050)3.99798610
19urea metabolic process (GO:0019627)3.99798610
20negative regulation of cholesterol transport (GO:0032375)3.95373324
21negative regulation of sterol transport (GO:0032372)3.95373324
22regulation of bile acid biosynthetic process (GO:0070857)3.90420963
23bile acid metabolic process (GO:0008206)3.86070009
24piRNA metabolic process (GO:0034587)3.85575914
25glutamate metabolic process (GO:0006536)3.85266606
26intestinal cholesterol absorption (GO:0030299)3.84053244
27glyoxylate metabolic process (GO:0046487)3.83470408
28regulation of cholesterol esterification (GO:0010872)3.82026275
29protein polyglutamylation (GO:0018095)3.80207175
30cysteine metabolic process (GO:0006534)3.79775447
31tryptophan metabolic process (GO:0006568)3.71856752
32regulation of cholesterol homeostasis (GO:2000188)3.67801724
33protein-lipid complex remodeling (GO:0034368)3.66629748
34macromolecular complex remodeling (GO:0034367)3.66629748
35plasma lipoprotein particle remodeling (GO:0034369)3.66629748
36bile acid and bile salt transport (GO:0015721)3.64691331
37homocysteine metabolic process (GO:0050667)3.59187743
38cholesterol efflux (GO:0033344)3.58534155
39nitrogen cycle metabolic process (GO:0071941)3.58431096
40serine family amino acid catabolic process (GO:0009071)3.56727065
41flavonoid metabolic process (GO:0009812)3.56002695
42nephron epithelium morphogenesis (GO:0072088)3.53361004
43nephron tubule morphogenesis (GO:0072078)3.53361004
44dicarboxylic acid biosynthetic process (GO:0043650)3.49772171
45regulation of triglyceride catabolic process (GO:0010896)3.48513084
46phospholipid efflux (GO:0033700)3.45945411
47negative regulation of fibrinolysis (GO:0051918)3.45574581
48triglyceride homeostasis (GO:0070328)3.45041809
49acylglycerol homeostasis (GO:0055090)3.45041809
50L-fucose catabolic process (GO:0042355)3.42507685
51fucose catabolic process (GO:0019317)3.42507685
52L-fucose metabolic process (GO:0042354)3.42507685
53intestinal absorption (GO:0050892)3.40344868
54regulation of fibrinolysis (GO:0051917)3.40250409
55DNA methylation involved in gamete generation (GO:0043046)3.39897652
56regulation of protein activation cascade (GO:2000257)3.39691040
57plasma lipoprotein particle assembly (GO:0034377)3.38156911
58cellular ketone body metabolic process (GO:0046950)3.36462349
59exogenous drug catabolic process (GO:0042738)3.35761828
60very-low-density lipoprotein particle assembly (GO:0034379)3.35301120
61alpha-amino acid catabolic process (GO:1901606)3.35156227
62coenzyme catabolic process (GO:0009109)3.30157988
63cellular modified amino acid catabolic process (GO:0042219)3.29115828
64aromatic amino acid family metabolic process (GO:0009072)3.25287432
65amino-acid betaine metabolic process (GO:0006577)3.25096713
66cellular amino acid catabolic process (GO:0009063)3.22656846
67lysine metabolic process (GO:0006553)3.21963469
68lysine catabolic process (GO:0006554)3.21963469
69protein carboxylation (GO:0018214)3.19709017
70peptidyl-glutamic acid carboxylation (GO:0017187)3.19709017
71nonmotile primary cilium assembly (GO:0035058)3.19617499
72meiotic chromosome segregation (GO:0045132)3.17244197
73regulation of complement activation (GO:0030449)3.15489043
74complement activation, alternative pathway (GO:0006957)3.15268925
75heme transport (GO:0015886)3.14877000
76sulfate transmembrane transport (GO:1902358)3.11466848
77cholesterol homeostasis (GO:0042632)3.11243605
78cellular glucuronidation (GO:0052695)3.11105800
79sterol homeostasis (GO:0055092)3.07344796
80ethanol oxidation (GO:0006069)3.06018116
81protein-lipid complex assembly (GO:0065005)3.03712523
82very long-chain fatty acid metabolic process (GO:0000038)3.02006882
83preassembly of GPI anchor in ER membrane (GO:0016254)3.01420745
84short-chain fatty acid metabolic process (GO:0046459)3.00982403
85fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.99134904
86detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.99064966
87tyrosine metabolic process (GO:0006570)2.98528717
88drug transmembrane transport (GO:0006855)2.98269578
89postsynaptic membrane organization (GO:0001941)2.96543142
90kidney morphogenesis (GO:0060993)2.96316238
91detection of light stimulus involved in visual perception (GO:0050908)2.95895975
92detection of light stimulus involved in sensory perception (GO:0050962)2.95895975
93drug metabolic process (GO:0017144)2.94989484
94regulation of nuclear cell cycle DNA replication (GO:0033262)2.92921443
95gamma-aminobutyric acid transport (GO:0015812)2.92250947
96plasma lipoprotein particle clearance (GO:0034381)2.91811986
97protein localization to cilium (GO:0061512)2.89368294
98positive regulation of triglyceride lipase activity (GO:0061365)2.89188595
99positive regulation of lipoprotein lipase activity (GO:0051006)2.89188595
100low-density lipoprotein particle remodeling (GO:0034374)2.88141770
101vocalization behavior (GO:0071625)2.87589920
102ketone body metabolic process (GO:1902224)2.85895498
103plasma lipoprotein particle organization (GO:0071827)2.85350138
104dicarboxylic acid catabolic process (GO:0043649)2.83820015
105arginine metabolic process (GO:0006525)2.83528471
106phospholipid homeostasis (GO:0055091)2.82633179
107sulfate transport (GO:0008272)2.82285522
108aspartate family amino acid catabolic process (GO:0009068)2.81733703
109serine family amino acid metabolic process (GO:0009069)2.81607777
110indolalkylamine metabolic process (GO:0006586)2.81593669
111male meiosis I (GO:0007141)2.80539643
112lipoprotein metabolic process (GO:0042157)2.80167430
113benzene-containing compound metabolic process (GO:0042537)2.79720355
114negative regulation of lipase activity (GO:0060192)2.77783039
115glycine metabolic process (GO:0006544)2.74534310
116epithelial cilium movement (GO:0003351)2.72996010
117positive regulation of lipid catabolic process (GO:0050996)2.72202895
118amine catabolic process (GO:0009310)2.71215847
119cellular biogenic amine catabolic process (GO:0042402)2.71215847
120regulation of action potential (GO:0098900)2.70637445
121nucleobase catabolic process (GO:0046113)2.69593643
122imidazole-containing compound metabolic process (GO:0052803)2.69046340
123protein-lipid complex subunit organization (GO:0071825)2.68757060
124cornea development in camera-type eye (GO:0061303)2.68639757
125somite development (GO:0061053)2.67897349
126regulation of short-term neuronal synaptic plasticity (GO:0048172)2.67764432
127organic acid catabolic process (GO:0016054)2.67390354
128water-soluble vitamin biosynthetic process (GO:0042364)2.64525220
129cellular response to ATP (GO:0071318)2.63272183
130neuronal action potential (GO:0019228)2.63024322
131reciprocal meiotic recombination (GO:0007131)2.63014977
132reciprocal DNA recombination (GO:0035825)2.63014977
133pyrimidine nucleobase catabolic process (GO:0006208)2.62233785
134presynaptic membrane assembly (GO:0097105)2.61790412
135head development (GO:0060322)2.60650042
136mannosylation (GO:0097502)2.60494598
137male meiosis (GO:0007140)2.59392123
138dendritic spine morphogenesis (GO:0060997)2.57540181
139G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56671969
140cilium morphogenesis (GO:0060271)2.55733067
141axon ensheathment in central nervous system (GO:0032291)2.55605863
142central nervous system myelination (GO:0022010)2.55605863
143mitochondrial respiratory chain complex I assembly (GO:0032981)2.55231306
144NADH dehydrogenase complex assembly (GO:0010257)2.55231306
145mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55231306
146regulation of hippo signaling (GO:0035330)2.52766600
147regulation of translation, ncRNA-mediated (GO:0045974)2.51908783
148negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.51908783
149negative regulation of translation, ncRNA-mediated (GO:0040033)2.51908783
150parturition (GO:0007567)2.51242189
151axoneme assembly (GO:0035082)2.50432018
152protein complex biogenesis (GO:0070271)2.49574553
153fucosylation (GO:0036065)2.49544386
154epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.49138178
155spinal cord development (GO:0021510)2.48364599
156neuromuscular synaptic transmission (GO:0007274)2.47449706
157protein localization to synapse (GO:0035418)2.45530890
158presynaptic membrane organization (GO:0097090)2.45291014
159purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.45229033
1603-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.45229033
161sperm motility (GO:0030317)2.44970456
162respiratory chain complex IV assembly (GO:0008535)2.43970255
163auditory receptor cell stereocilium organization (GO:0060088)2.42655793
164cilium organization (GO:0044782)2.42562235
165reflex (GO:0060004)2.42409603
166sex differentiation (GO:0007548)2.41183693
167synaptic transmission, cholinergic (GO:0007271)2.40819593
168regulation of cilium movement (GO:0003352)2.40581692
169negative regulation of transcription regulatory region DNA binding (GO:2000678)2.40564254
170renal tubule morphogenesis (GO:0061333)2.39651279
171photoreceptor cell maintenance (GO:0045494)2.39352041
172cilium assembly (GO:0042384)2.38740806
173inner ear receptor stereocilium organization (GO:0060122)2.38437954
174bicarbonate transport (GO:0015701)2.36630997
175peristalsis (GO:0030432)2.36423610
176response to pheromone (GO:0019236)2.36019213
177transmission of nerve impulse (GO:0019226)2.35839308
178intraciliary transport (GO:0042073)2.35527754
179regulation of guanylate cyclase activity (GO:0031282)2.34028975
180mitochondrial respiratory chain complex assembly (GO:0033108)2.32632251
181negative regulation of telomere maintenance (GO:0032205)2.32631229
182synapsis (GO:0007129)2.32595496
183primary amino compound metabolic process (GO:1901160)2.32159942
184sulfation (GO:0051923)2.31344913
185positive regulation of sodium ion transmembrane transport (GO:1902307)2.30709331
186spinal cord motor neuron differentiation (GO:0021522)2.30525985
187retinal ganglion cell axon guidance (GO:0031290)2.30339290
188auditory behavior (GO:0031223)2.30310581
189cell differentiation in spinal cord (GO:0021515)2.29734514
190tRNA modification (GO:0006400)2.29375570
191auditory receptor cell differentiation (GO:0042491)2.29277959
192somite rostral/caudal axis specification (GO:0032525)2.27704517

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.00423179
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.38848262
3ZNF274_21170338_ChIP-Seq_K562_Hela4.01902682
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.68045097
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.60109177
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.04208999
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.88854666
8EZH2_22144423_ChIP-Seq_EOC_Human2.65727985
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.58998846
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28678560
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26150318
12IGF1R_20145208_ChIP-Seq_DFB_Human2.25546935
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16969438
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.04165310
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00983027
16ERG_21242973_ChIP-ChIP_JURKAT_Human1.97438797
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93277392
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85175492
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81748790
20* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80779217
21ER_23166858_ChIP-Seq_MCF-7_Human1.80596882
22DROSHA_22980978_ChIP-Seq_HELA_Human1.79666739
23FUS_26573619_Chip-Seq_HEK293_Human1.75233227
24GBX2_23144817_ChIP-Seq_PC3_Human1.74148737
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72143647
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70889364
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70674100
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69490731
29* RARB_27405468_Chip-Seq_BRAIN_Mouse1.69190051
30EWS_26573619_Chip-Seq_HEK293_Human1.66683614
31REST_21632747_ChIP-Seq_MESCs_Mouse1.65094691
32TAF15_26573619_Chip-Seq_HEK293_Human1.63906711
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63179034
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62311644
35IRF1_19129219_ChIP-ChIP_H3396_Human1.61578291
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61401440
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60512746
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58370239
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57808773
40TP53_22573176_ChIP-Seq_HFKS_Human1.57002937
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55243532
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55243532
43RNF2_27304074_Chip-Seq_NSC_Mouse1.52973864
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.51807249
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51533626
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50738838
47MYC_18940864_ChIP-ChIP_HL60_Human1.49649563
48P300_19829295_ChIP-Seq_ESCs_Human1.49495590
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48954923
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47863254
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47304573
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.46889733
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44365677
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43973555
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42321203
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40583981
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.40555147
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39006797
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.37225097
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34357090
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34357090
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.33597400
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32724139
64ERA_21632823_ChIP-Seq_H3396_Human1.31925254
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.31399987
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30683415
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.30422623
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28282103
69CBP_20019798_ChIP-Seq_JUKART_Human1.27085409
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27085409
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27023836
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26723906
73AR_21572438_ChIP-Seq_LNCaP_Human1.26640744
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23866390
75SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22647666
76HOXB7_26014856_ChIP-Seq_BT474_Human1.21921384
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21108865
78TCF4_23295773_ChIP-Seq_U87_Human1.20322706
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.19209820
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18648934
81NCOR_22424771_ChIP-Seq_293T_Human1.18265778
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17448482
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.17448482
84AR_25329375_ChIP-Seq_VCAP_Human1.17071601
85RNF2_27304074_Chip-Seq_ESCs_Mouse1.16470270
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16365646
87GATA3_21878914_ChIP-Seq_MCF-7_Human1.15533295
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13413106
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13120164
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12964632
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12426264
92SMAD4_21799915_ChIP-Seq_A2780_Human1.12424377
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12217673
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12192644
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11933012
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11767715
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11732964
98TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11113249
99CDX2_20551321_ChIP-Seq_CACO-2_Human1.10921146
100TCF4_22108803_ChIP-Seq_LS180_Human1.09888875
101TAF2_19829295_ChIP-Seq_ESCs_Human1.08602060
102CTCF_27219007_Chip-Seq_Bcells_Human1.08594075
103ZNF263_19887448_ChIP-Seq_K562_Human1.08460167
104EZH2_27304074_Chip-Seq_ESCs_Mouse1.07924917
105EST1_17652178_ChIP-ChIP_JURKAT_Human1.07202123
106DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06511756
107HTT_18923047_ChIP-ChIP_STHdh_Human1.05937112
108* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05545532
109* HNF4A_19822575_ChIP-Seq_HepG2_Human1.05422408
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.05266752
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05101921
112* KDM2B_26808549_Chip-Seq_K562_Human1.02972004
113OCT4_20526341_ChIP-Seq_ESCs_Human1.02086025
114NANOG_20526341_ChIP-Seq_ESCs_Human1.01576877
115RUNX2_22187159_ChIP-Seq_PCA_Human1.01217941
116RING1B_27294783_Chip-Seq_ESCs_Mouse1.01038925
117ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00823761
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00537451
119POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00359552
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00123974
121* P53_21459846_ChIP-Seq_SAOS-2_Human1.00033501
122MYC_19829295_ChIP-Seq_ESCs_Human0.99640612
123NANOG_19829295_ChIP-Seq_ESCs_Human0.99598086
124SOX2_19829295_ChIP-Seq_ESCs_Human0.99598086
125RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99517943
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99137495
127AR_20517297_ChIP-Seq_VCAP_Human0.98874757
128EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98783040
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98321265
130CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98311095
131FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97285256
132NOTCH1_21737748_ChIP-Seq_TLL_Human0.96679808
133CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96620523
134* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94495875
135AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94298639
136* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93365525
137CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92423149
138* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92237809
139RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91902363
140CREB1_26743006_Chip-Seq_LNCaP_Human0.91570413
141CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90167671
142* IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89715236
143PIAS1_25552417_ChIP-Seq_VCAP_Human0.89400254
144AR_19668381_ChIP-Seq_PC3_Human0.85791580
145LXR_22292898_ChIP-Seq_THP-1_Human0.84926958
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.84375174
147ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84273731
148TP53_16413492_ChIP-PET_HCT116_Human0.83186680
149BCAT_22108803_ChIP-Seq_LS180_Human0.82130305
150CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81655351
151NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.81520457
152CLOCK_20551151_ChIP-Seq_293T_Human0.81301134
153WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80242246
154ZFP281_27345836_Chip-Seq_ESCs_Mouse0.78945451
155* TET1_21490601_ChIP-Seq_MESCs_Mouse0.78562972
156SOX2_21211035_ChIP-Seq_LN229_Gbm0.78537375
157HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78419214
158RING1B_27294783_Chip-Seq_NPCs_Mouse0.78414387
159AHR_22903824_ChIP-Seq_MCF-7_Human0.78369141
160AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77950904
161ARNT_22903824_ChIP-Seq_MCF-7_Human0.77518483
162MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.77388662
163SMAD3_21741376_ChIP-Seq_HESCs_Human0.76869940
164* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.76815315
165SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.75161144
166CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.74743984
167VDR_22108803_ChIP-Seq_LS180_Human0.74686494
168ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74597863
169SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.74564651
170KLF4_19829295_ChIP-Seq_ESCs_Human0.72297356
171GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70580196
172STAT3_23295773_ChIP-Seq_U87_Human0.69840910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.38885051
2MP0002139_abnormal_hepatobiliary_system6.14345694
3MP0005085_abnormal_gallbladder_physiolo4.88830626
4MP0005365_abnormal_bile_salt4.36246145
5MP0008875_abnormal_xenobiotic_pharmacok4.02105995
6MP0004859_abnormal_synaptic_plasticity3.03645174
7MP0010329_abnormal_lipoprotein_level2.88521736
8MP0003252_abnormal_bile_duct2.84970465
9MP0003806_abnormal_nucleotide_metabolis2.82450859
10MP0001666_abnormal_nutrient_absorption2.70535289
11MP0009840_abnormal_foam_cell2.50940058
12MP0008877_abnormal_DNA_methylation2.49912472
13MP0002822_catalepsy2.40338226
14MP0003329_amyloid_beta_deposits2.26272032
15MP0006292_abnormal_olfactory_placode2.16249250
16MP0005332_abnormal_amino_acid2.09802907
17MP0003195_calcinosis2.05467475
18MP0003136_yellow_coat_color2.04682441
19MP0004270_analgesia1.95649594
20MP0004885_abnormal_endolymph1.88576116
21MP0002938_white_spotting1.86686396
22MP0003635_abnormal_synaptic_transmissio1.82805518
23MP0005083_abnormal_biliary_tract1.80324106
24MP0003880_abnormal_central_pattern1.78407938
25MP0001986_abnormal_taste_sensitivity1.71516114
26MP0002638_abnormal_pupillary_reflex1.69613879
27MP0006276_abnormal_autonomic_nervous1.69126710
28MP0004019_abnormal_vitamin_homeostasis1.68971844
29MP0001529_abnormal_vocalization1.68755365
30MP0003787_abnormal_imprinting1.62412681
31MP0001440_abnormal_grooming_behavior1.62002947
32MP0005645_abnormal_hypothalamus_physiol1.61815683
33MP0010234_abnormal_vibrissa_follicle1.60034003
34MP0002118_abnormal_lipid_homeostasis1.59414449
35MP0000427_abnormal_hair_cycle1.58565985
36MP0002063_abnormal_learning/memory/cond1.55842380
37MP0003878_abnormal_ear_physiology1.54029652
38MP0005377_hearing/vestibular/ear_phenot1.54029652
39MP0000569_abnormal_digit_pigmentation1.53945255
40MP0000604_amyloidosis1.53457404
41MP0005174_abnormal_tail_pigmentation1.53354458
42MP0006072_abnormal_retinal_apoptosis1.51394767
43MP0002102_abnormal_ear_morphology1.51049765
44MP0009745_abnormal_behavioral_response1.50458941
45MP0001486_abnormal_startle_reflex1.49175099
46MP0004133_heterotaxia1.44472427
47MP0002653_abnormal_ependyma_morphology1.43732692
48MP0003879_abnormal_hair_cell1.42823749
49MP0000566_synostosis1.41951278
50MP0002064_seizures1.40118120
51MP0005646_abnormal_pituitary_gland1.40023410
52MP0003868_abnormal_feces_composition1.40010653
53MP0002735_abnormal_chemical_nociception1.39380502
54MP0000462_abnormal_digestive_system1.39062143
55MP0002572_abnormal_emotion/affect_behav1.36399430
56MP0002160_abnormal_reproductive_system1.35307832
57MP0000609_abnormal_liver_physiology1.33364908
58MP0000631_abnormal_neuroendocrine_gland1.32768425
59MP0003011_delayed_dark_adaptation1.27010814
60MP0008872_abnormal_physiological_respon1.25255137
61MP0002184_abnormal_innervation1.22921262
62MP0001188_hyperpigmentation1.22386315
63MP0003121_genomic_imprinting1.22021258
64MP0004264_abnormal_extraembryonic_tissu1.17526606
65MP0003283_abnormal_digestive_organ1.17371843
66MP0009780_abnormal_chondrocyte_physiolo1.17231740
67* MP0002272_abnormal_nervous_system1.16568711
68* MP0005253_abnormal_eye_physiology1.15786513
69MP0004043_abnormal_pH_regulation1.14748394
70MP0009046_muscle_twitch1.13979972
71MP0003122_maternal_imprinting1.13525200
72MP0000026_abnormal_inner_ear1.12820180
73* MP0003698_abnormal_male_reproductive1.10512319
74MP0005389_reproductive_system_phenotype1.09008789
75* MP0002210_abnormal_sex_determination1.07778074
76MP0004858_abnormal_nervous_system1.07460545
77MP0002928_abnormal_bile_duct1.07031530
78MP0003890_abnormal_embryonic-extraembry1.06276630
79* MP0002752_abnormal_somatic_nervous1.06254468
80MP0003191_abnormal_cellular_cholesterol1.04956842
81MP0003646_muscle_fatigue1.04793330
82MP0005647_abnormal_sex_gland1.04347692
83MP0002163_abnormal_gland_morphology1.02240975
84MP0005584_abnormal_enzyme/coenzyme_acti1.01794169
85MP0001501_abnormal_sleep_pattern1.01485380
86MP0001919_abnormal_reproductive_system1.01144832
87MP0003718_maternal_effect1.00538852
88MP0005319_abnormal_enzyme/_coenzyme1.00518220
89MP0000538_abnormal_urinary_bladder0.99858858
90MP0008058_abnormal_DNA_repair0.98466068
91MP0001984_abnormal_olfaction0.97819128
92* MP0001929_abnormal_gametogenesis0.97250826
93MP0002909_abnormal_adrenal_gland0.97247894
94MP0002254_reproductive_system_inflammat0.96921917
95MP0002751_abnormal_autonomic_nervous0.96703615
96MP0002837_dystrophic_cardiac_calcinosis0.96544686
97* MP0005195_abnormal_posterior_eye0.96432643
98MP0008789_abnormal_olfactory_epithelium0.95677957
99MP0004145_abnormal_muscle_electrophysio0.95453200
100MP0005423_abnormal_somatic_nervous0.93544167
101* MP0003690_abnormal_glial_cell0.93143367
102MP0003656_abnormal_erythrocyte_physiolo0.91956210
103MP0003632_abnormal_nervous_system0.90981223
104MP0002234_abnormal_pharynx_morphology0.88957050
105MP0008995_early_reproductive_senescence0.88735443
106MP0004147_increased_porphyrin_level0.88701022
107MP0003705_abnormal_hypodermis_morpholog0.87233081
108MP0001485_abnormal_pinna_reflex0.85788731
109MP0000537_abnormal_urethra_morphology0.85347765
110MP0003937_abnormal_limbs/digits/tail_de0.85329194
111* MP0000653_abnormal_sex_gland0.85156048
112* MP0001145_abnormal_male_reproductive0.83816633
113MP0002733_abnormal_thermal_nociception0.82917392
114MP0001968_abnormal_touch/_nociception0.82587976
115MP0005187_abnormal_penis_morphology0.81475295
116MP0002734_abnormal_mechanical_nocicepti0.80825001
117MP0002557_abnormal_social/conspecific_i0.77251688
118* MP0000778_abnormal_nervous_system0.76631127
119MP0001664_abnormal_digestion0.76592191
120MP0001764_abnormal_homeostasis0.74956150
121MP0002067_abnormal_sensory_capabilities0.72592437
122MP0005386_behavior/neurological_phenoty0.71474761
123MP0004924_abnormal_behavior0.71474761
124* MP0000955_abnormal_spinal_cord0.70325930
125MP0005410_abnormal_fertilization0.70161227
126MP0008874_decreased_physiological_sensi0.69947610
127MP0002066_abnormal_motor_capabilities/c0.68540391
128* MP0003631_nervous_system_phenotype0.68158715
129MP0000639_abnormal_adrenal_gland0.67333126
130MP0001661_extended_life_span0.67326878
131MP0009643_abnormal_urine_homeostasis0.67120235
132MP0002736_abnormal_nociception_after0.67017380
133MP0002069_abnormal_eating/drinking_beha0.66953574
134MP0002876_abnormal_thyroid_physiology0.65895157
135MP0001502_abnormal_circadian_rhythm0.65453815
136MP0005636_abnormal_mineral_homeostasis0.65095822
137MP0005535_abnormal_body_temperature0.64291001
138MP0004742_abnormal_vestibular_system0.63342529
139MP0005448_abnormal_energy_balance0.62606250
140* MP0002229_neurodegeneration0.62495917
141* MP0003633_abnormal_nervous_system0.61750318
142MP0000920_abnormal_myelination0.61065423
143MP0003119_abnormal_digestive_system0.59906339
144MP0000467_abnormal_esophagus_morphology0.59866566
145MP0005266_abnormal_metabolism0.57482704
146MP0009697_abnormal_copulation0.55607462
147* MP0002882_abnormal_neuron_morphology0.55508720
148* MP0005551_abnormal_eye_electrophysiolog0.55147121
149MP0001963_abnormal_hearing_physiology0.55143476
150MP0008569_lethality_at_weaning0.53694589
151MP0004142_abnormal_muscle_tone0.53512892
152MP0001765_abnormal_ion_homeostasis0.53453314
153MP0001970_abnormal_pain_threshold0.52687441

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.58238468
2Deep venous thrombosis (HP:0002625)5.28210658
3Hypobetalipoproteinemia (HP:0003563)5.26827871
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.16842247
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.74385903
6Xanthomatosis (HP:0000991)4.65346764
7Prolonged partial thromboplastin time (HP:0003645)4.25487258
8Hyperlipoproteinemia (HP:0010980)4.00640582
9Congenital stationary night blindness (HP:0007642)3.83880341
10Hypolipoproteinemia (HP:0010981)3.77541218
11True hermaphroditism (HP:0010459)3.67753579
12Abnormality of glutamine family amino acid metabolism (HP:0010902)3.66720933
13Pancreatic cysts (HP:0001737)3.56943560
14Abnormality of sulfur amino acid metabolism (HP:0004339)3.50649638
15Nephronophthisis (HP:0000090)3.49505033
16Molar tooth sign on MRI (HP:0002419)3.45212765
17Abnormality of midbrain morphology (HP:0002418)3.45212765
18Hyperammonemia (HP:0001987)3.43761922
19Hyperglycinemia (HP:0002154)3.42194089
20Hyperglycinuria (HP:0003108)3.41342401
21Abnormality of the lower motor neuron (HP:0002366)3.38211994
22Epidermoid cyst (HP:0200040)3.36952848
23Pancreatic fibrosis (HP:0100732)3.33777050
24Abnormality of glycine metabolism (HP:0010895)3.32809550
25Abnormality of serine family amino acid metabolism (HP:0010894)3.32809550
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.27302609
27Ileus (HP:0002595)3.25082212
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.23386094
29Conjugated hyperbilirubinemia (HP:0002908)3.22933731
30Complement deficiency (HP:0004431)3.19238149
31Type II lissencephaly (HP:0007260)3.17240292
32Myokymia (HP:0002411)3.13696598
33Neurofibrillary tangles (HP:0002185)3.11761861
34Cerebral inclusion bodies (HP:0100314)3.10979607
35Decreased circulating renin level (HP:0003351)3.10272009
36Abnormality of the renal medulla (HP:0100957)3.10267378
37Fat malabsorption (HP:0002630)3.07756667
38Hypoalphalipoproteinemia (HP:0003233)3.06579625
39Focal motor seizures (HP:0011153)3.05612512
40Abnormality of methionine metabolism (HP:0010901)3.03796369
41Ketosis (HP:0001946)2.93386766
42Status epilepticus (HP:0002133)2.92922694
43Acanthocytosis (HP:0001927)2.89422672
44Malnutrition (HP:0004395)2.88710302
45Spontaneous abortion (HP:0005268)2.85103464
46Pendular nystagmus (HP:0012043)2.83333221
47Attenuation of retinal blood vessels (HP:0007843)2.82072592
48Cerebellar dysplasia (HP:0007033)2.78505108
49Confusion (HP:0001289)2.75204237
50Hypercholesterolemia (HP:0003124)2.72573697
51Abnormality of the renal cortex (HP:0011035)2.71592285
52Hyperventilation (HP:0002883)2.70568234
53Cystic liver disease (HP:0006706)2.70038334
54Genetic anticipation (HP:0003743)2.61861267
55Medial flaring of the eyebrow (HP:0010747)2.60818410
56Abnormality of the pons (HP:0007361)2.60375361
57Chronic hepatic failure (HP:0100626)2.58731690
58Rib fusion (HP:0000902)2.52989065
59Tubular atrophy (HP:0000092)2.52874606
60Hyperbilirubinemia (HP:0002904)2.50359442
61Focal seizures (HP:0007359)2.49994336
62Hypoplasia of the pons (HP:0012110)2.49909729
63Hypochromic microcytic anemia (HP:0004840)2.47922957
64Lissencephaly (HP:0001339)2.46768120
65Sclerocornea (HP:0000647)2.42822176
66Delayed CNS myelination (HP:0002188)2.38331596
67Patellar aplasia (HP:0006443)2.33439575
68Abnormality of renin-angiotensin system (HP:0000847)2.32224141
69Turricephaly (HP:0000262)2.30026155
70Skin nodule (HP:0200036)2.27655855
71Abnormal gallbladder physiology (HP:0012438)2.26660882
72Cholecystitis (HP:0001082)2.26660882
73Abnormality of the common coagulation pathway (HP:0010990)2.26473867
74Duplicated collecting system (HP:0000081)2.26307611
75Joint hemorrhage (HP:0005261)2.25718434
76Progressive cerebellar ataxia (HP:0002073)2.25059854
77Gait imbalance (HP:0002141)2.23330241
78Poikilocytosis (HP:0004447)2.22565865
79Male infertility (HP:0003251)2.20850270
80Vascular calcification (HP:0004934)2.20289062
81Broad-based gait (HP:0002136)2.20251300
82Aplasia/Hypoplasia of the patella (HP:0006498)2.18987507
83Abnormal drinking behavior (HP:0030082)2.18291315
84Polydipsia (HP:0001959)2.18291315
85Bony spicule pigmentary retinopathy (HP:0007737)2.18244147
86Abnormality of the renal collecting system (HP:0004742)2.16385101
87Epileptic encephalopathy (HP:0200134)2.14806061
88Ankle clonus (HP:0011448)2.14610948
893-Methylglutaconic aciduria (HP:0003535)2.13242107
90Cholelithiasis (HP:0001081)2.12837409
91Generalized tonic-clonic seizures (HP:0002069)2.11989492
92Abnormal gallbladder morphology (HP:0012437)2.11646597
93Abnormality of the corticospinal tract (HP:0002492)2.10975236
94Large for gestational age (HP:0001520)2.10091542
95Congenital primary aphakia (HP:0007707)2.08098369
96Concave nail (HP:0001598)2.08065095
97Chorioretinal atrophy (HP:0000533)2.07790225
98Pseudobulbar signs (HP:0002200)2.06838046
99Male pseudohermaphroditism (HP:0000037)2.06580966
100Ketoacidosis (HP:0001993)2.05770887
101Impaired social interactions (HP:0000735)2.05344597
102Abnormal social behavior (HP:0012433)2.05344597
103Metabolic alkalosis (HP:0200114)2.05081768
104Irritability (HP:0000737)2.04415105
105Insidious onset (HP:0003587)2.04193033
106Termporal pattern (HP:0011008)2.04193033
107Protruding tongue (HP:0010808)2.04002951
108Metabolic acidosis (HP:0001942)2.02907530
109Acute necrotizing encephalopathy (HP:0006965)2.01759712
110Oligodactyly (hands) (HP:0001180)2.01330447
111Supranuclear gaze palsy (HP:0000605)2.01261830
112Abnormality of pyrimidine metabolism (HP:0004353)1.98149398
113Clonus (HP:0002169)1.97768867
114Action tremor (HP:0002345)1.96875799
115Anencephaly (HP:0002323)1.96809182
116Reticulocytosis (HP:0001923)1.96284887
117Intention tremor (HP:0002080)1.96202428
118Hypoglycemic coma (HP:0001325)1.95863171
119Abnormality of complement system (HP:0005339)1.95330127
120Mitochondrial inheritance (HP:0001427)1.94599888
121Postural instability (HP:0002172)1.94352833
122Abnormal rod and cone electroretinograms (HP:0008323)1.94154056
123Gaze-evoked nystagmus (HP:0000640)1.93565864
124Increased CSF lactate (HP:0002490)1.93399227
125Back pain (HP:0003418)1.93064418
126Dysdiadochokinesis (HP:0002075)1.92965432
127Congenital hepatic fibrosis (HP:0002612)1.91899086
128Congenital, generalized hypertrichosis (HP:0004540)1.91883551
129Spastic gait (HP:0002064)1.91676081
130Gout (HP:0001997)1.91187862
131Abolished electroretinogram (ERG) (HP:0000550)1.91185317
132Bile duct proliferation (HP:0001408)1.91005980
133Abnormal biliary tract physiology (HP:0012439)1.91005980
134Nephrogenic diabetes insipidus (HP:0009806)1.90969470
135Spastic tetraparesis (HP:0001285)1.90422422
136Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89800716
137Abnormality of alanine metabolism (HP:0010916)1.89800716
138Hyperalaninemia (HP:0003348)1.89800716
139Abnormality of the intrinsic pathway (HP:0010989)1.87861429
140Dysmetria (HP:0001310)1.87518324
141Pachygyria (HP:0001302)1.87432225
142Tachypnea (HP:0002789)1.87388301
143Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86944672
144Abnormality of the labia minora (HP:0012880)1.86883653
145Acute encephalopathy (HP:0006846)1.86575166
146Cardiovascular calcification (HP:0011915)1.86354438
147Hemiparesis (HP:0001269)1.84962519
148Tetraplegia (HP:0002445)1.84362680
149Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.84292255
150Alkalosis (HP:0001948)1.83960995
151Hepatocellular carcinoma (HP:0001402)1.82325754
152Abnormality of serum amino acid levels (HP:0003112)1.82189339
153Polyuria (HP:0000103)1.81988288
154Abnormality of vitamin metabolism (HP:0100508)1.81931711
155Rickets (HP:0002748)1.81797964
156Hydroxyprolinuria (HP:0003080)1.79264568
157Abnormality of proline metabolism (HP:0010907)1.79264568
158Severe muscular hypotonia (HP:0006829)1.79121537
159Aplasia/Hypoplasia of the tibia (HP:0005772)1.78834927
160Decreased central vision (HP:0007663)1.78834505
161Sensorimotor neuropathy (HP:0007141)1.77827113
162Abnormality of nucleobase metabolism (HP:0010932)1.77808777
163Abnormal number of erythroid precursors (HP:0012131)1.77672464
164Spastic diplegia (HP:0001264)1.77588059
165Renal cortical cysts (HP:0000803)1.77582576
166Retinal dysplasia (HP:0007973)1.77010783
167Genital tract atresia (HP:0001827)1.76837016
168Optic disc pallor (HP:0000543)1.76148971
169Absent speech (HP:0001344)1.76096045
170Steatorrhea (HP:0002570)1.75882219
171Aplasia/Hypoplasia of the uvula (HP:0010293)1.75363307
172Vaginal atresia (HP:0000148)1.75337157
173Global brain atrophy (HP:0002283)1.74431296
174Abnormal mitochondria in muscle tissue (HP:0008316)1.72241474
175Postaxial foot polydactyly (HP:0001830)1.72080392
176Clumsiness (HP:0002312)1.71508432
177Insomnia (HP:0100785)1.71412147
178Morphological abnormality of the pyramidal tract (HP:0002062)1.71318879
179Bilateral microphthalmos (HP:0007633)1.70664000
180Poor coordination (HP:0002370)1.70380763
181Methylmalonic aciduria (HP:0012120)1.69798569
182Inability to walk (HP:0002540)1.69521167
183Aplasia/Hypoplasia of the tongue (HP:0010295)1.69450111
184Keratoconus (HP:0000563)1.67858217
185Increased corneal curvature (HP:0100692)1.67858217
186Preaxial hand polydactyly (HP:0001177)1.67111787
187Anophthalmia (HP:0000528)1.66801689
188Hepatocellular necrosis (HP:0001404)1.66571757
189Abnormality of DNA repair (HP:0003254)1.65688595
190Colon cancer (HP:0003003)1.65503262
191Ectopic kidney (HP:0000086)1.65314212
192Optic nerve hypoplasia (HP:0000609)1.64569298
193Progressive macrocephaly (HP:0004481)1.61997245
194Abnormality of chloride homeostasis (HP:0011422)1.61191294

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.46259934
2CASK2.89696736
3LMTK22.82505540
4ADRBK22.71627204
5NTRK32.67894835
6TYRO32.58652585
7DAPK22.44343145
8GRK12.43498510
9ACVR1B2.40929976
10MAP3K92.40338537
11BMPR1B2.33644282
12MAP3K42.26993309
13MAP4K22.13799563
14ZAK2.13775937
15ICK2.11869516
16MAP2K42.08123486
17INSRR1.95015532
18MAPK131.94799328
19KSR21.90900023
20PNCK1.83552312
21NUAK11.81155975
22TLK11.80080996
23RIPK11.70319980
24PRKD31.68756991
25NEK21.66085388
26PAK61.59062364
27MINK11.57052118
28CAMK1D1.53537067
29SIK11.51326711
30MARK11.50356364
31EPHB21.44734537
32BCKDK1.44542950
33MAP3K21.38753615
34MAPK151.38740456
35TAOK31.37298441
36AKT31.34832447
37NTRK21.34615345
38MKNK21.27475710
39NTRK11.26576030
40DDR21.25993913
41TXK1.23493938
42DYRK21.22099210
43KSR11.15169337
44STK161.14006211
45TNIK1.13258795
46FGFR21.13160079
47GRK61.11534521
48CDK121.09841741
49PTK2B1.07712847
50MST1R1.04912766
51CAMKK21.04208624
52PRKCG1.03252773
53CDK51.03029909
54ERBB21.00968923
55MAP3K71.00405407
56DAPK11.00143051
57SGK2230.99826742
58SGK4940.99826742
59ERBB40.99101347
60MAP2K70.98605818
61TAOK10.95288985
62OXSR10.95009432
63SIK20.94234429
64MAP2K20.93554347
65PINK10.93246457
66PTK60.93144849
67CAMKK10.93114152
68STK380.92332099
69PIK3CA0.91815757
70CAMK1G0.91321495
71RIPK40.90796261
72LATS10.90488118
73CAMK2B0.89492272
74PRKCZ0.86966273
75MET0.86730690
76FRK0.86676733
77CAMK2G0.85895813
78ADRBK10.85431537
79PTK20.84319571
80EPHA20.81512991
81TAF10.80908616
82CAMK2A0.79919301
83STK110.78804503
84PRKCI0.77438112
85PDPK10.77074044
86PAK30.77034679
87SGK30.75635664
88VRK20.74614257
89WNK10.74475172
90PRKG20.71845211
91MAP2K10.71067264
92FGR0.70729940
93MUSK0.69175381
94STK390.68657208
95GRK50.68585387
96BRSK20.68497961
97FGFR40.67765710
98WEE10.67756280
99PRKCE0.66956162
100MAPK110.66680601
101PDGFRA0.66332287
102DYRK1A0.64458322
103BRD40.64298952
104BMX0.64118126
105NME10.63481180
106TSSK60.61914251
107LATS20.61801680
108PLK40.61063526
109TIE10.61000375
110FER0.60982082
111CDC42BPA0.60299621
112PRKAA10.60250519
113SGK10.59239171
114CSNK1E0.58973309
115WNK40.58328181
116ATR0.57053594
117RPS6KA30.56381754
118WNK30.56154773
119EPHB10.56094298
120STK38L0.55139959
121CAMK2D0.54185528
122TNK20.53801676
123PRKAA20.53226439
124MAP2K60.52786332
125CAMK10.52449377
126MAPKAPK50.51846431
127MARK20.51789630
128SGK20.51669288
129PDK10.51440787
130PHKG20.51381164
131PHKG10.51381164
132PRKACG0.50688157
133MAPK70.49913890
134VRK10.49510813
135RET0.48938229
136CHUK0.48704978
137TGFBR10.48420599
138ERN10.47843990
139CAMK40.47561508
140CSNK1A10.47514510
141CSNK1A1L0.46892764
142MKNK10.46284863
143PRKACA0.45410879
144CDK150.44918806
145CSNK1G20.44873905
146CSNK1G10.42923341
147CSNK1G30.42716776
148CHEK20.41634994
149PLK20.33518176
150TRIM280.32950993
151CCNB10.32746554
152BCR0.31539544
153PRKCA0.31196326

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.07737167
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.42213998
3Arginine biosynthesis_Homo sapiens_hsa002202.78585481
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.70570461
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.64706297
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.49736934
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44324046
8Phototransduction_Homo sapiens_hsa047442.29413423
9Bile secretion_Homo sapiens_hsa049762.28091546
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.08014779
11Tryptophan metabolism_Homo sapiens_hsa003802.05476860
12Linoleic acid metabolism_Homo sapiens_hsa005912.05310869
13Butanoate metabolism_Homo sapiens_hsa006502.02407783
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.97149635
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.97001688
16Oxidative phosphorylation_Homo sapiens_hsa001901.92316699
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91396948
18Fatty acid degradation_Homo sapiens_hsa000711.89130628
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85074647
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.83799616
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79597964
22Complement and coagulation cascades_Homo sapiens_hsa046101.77854852
23Sulfur metabolism_Homo sapiens_hsa009201.77742665
24Fat digestion and absorption_Homo sapiens_hsa049751.71500137
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.71362851
26Homologous recombination_Homo sapiens_hsa034401.69144463
27Fanconi anemia pathway_Homo sapiens_hsa034601.67127570
28Histidine metabolism_Homo sapiens_hsa003401.64774610
29PPAR signaling pathway_Homo sapiens_hsa033201.63373956
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.59969027
31Fatty acid metabolism_Homo sapiens_hsa012121.58813158
32Ether lipid metabolism_Homo sapiens_hsa005651.58211454
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56468776
34RNA polymerase_Homo sapiens_hsa030201.55257633
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50798839
36Chemical carcinogenesis_Homo sapiens_hsa052041.50553722
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50428628
38Parkinsons disease_Homo sapiens_hsa050121.49079409
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48361908
40Basal transcription factors_Homo sapiens_hsa030221.44878158
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38854481
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36572956
43Peroxisome_Homo sapiens_hsa041461.33839913
44Propanoate metabolism_Homo sapiens_hsa006401.29541707
45Vitamin digestion and absorption_Homo sapiens_hsa049771.28185484
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27724529
47beta-Alanine metabolism_Homo sapiens_hsa004101.25149818
48Retinol metabolism_Homo sapiens_hsa008301.22553535
49Pyruvate metabolism_Homo sapiens_hsa006201.19198333
50Huntingtons disease_Homo sapiens_hsa050161.18653223
51Cardiac muscle contraction_Homo sapiens_hsa042601.15431125
52Caffeine metabolism_Homo sapiens_hsa002321.14271305
53Nicotine addiction_Homo sapiens_hsa050331.11803806
54Starch and sucrose metabolism_Homo sapiens_hsa005001.11369501
55ABC transporters_Homo sapiens_hsa020101.10729571
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.07802841
57Fatty acid elongation_Homo sapiens_hsa000621.07549766
58Protein export_Homo sapiens_hsa030601.05391277
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05286873
60Steroid biosynthesis_Homo sapiens_hsa001001.03614116
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.01696874
62Fatty acid biosynthesis_Homo sapiens_hsa000610.99587443
63Glycerolipid metabolism_Homo sapiens_hsa005610.99505986
64Selenocompound metabolism_Homo sapiens_hsa004500.99429768
65Arginine and proline metabolism_Homo sapiens_hsa003300.98382021
66Biosynthesis of amino acids_Homo sapiens_hsa012300.98269851
67Vitamin B6 metabolism_Homo sapiens_hsa007500.95738968
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.94190076
69Alzheimers disease_Homo sapiens_hsa050100.91856422
70Phenylalanine metabolism_Homo sapiens_hsa003600.88183947
71Lysine degradation_Homo sapiens_hsa003100.86109446
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.85458363
73Glutamatergic synapse_Homo sapiens_hsa047240.84805261
74GABAergic synapse_Homo sapiens_hsa047270.84224475
75Regulation of autophagy_Homo sapiens_hsa041400.83304661
76Folate biosynthesis_Homo sapiens_hsa007900.83185907
77Ovarian steroidogenesis_Homo sapiens_hsa049130.82064638
78* Mineral absorption_Homo sapiens_hsa049780.81746765
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81525646
80Basal cell carcinoma_Homo sapiens_hsa052170.81346377
81Tyrosine metabolism_Homo sapiens_hsa003500.79947200
82RNA degradation_Homo sapiens_hsa030180.79442654
83One carbon pool by folate_Homo sapiens_hsa006700.78936448
84Salivary secretion_Homo sapiens_hsa049700.78367837
85Carbon metabolism_Homo sapiens_hsa012000.74871406
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73756554
87Serotonergic synapse_Homo sapiens_hsa047260.69820432
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.66867198
89Amphetamine addiction_Homo sapiens_hsa050310.66361178
90Hedgehog signaling pathway_Homo sapiens_hsa043400.66332571
91Long-term potentiation_Homo sapiens_hsa047200.64859197
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63769572
93Arachidonic acid metabolism_Homo sapiens_hsa005900.62666629
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60865527
95Gastric acid secretion_Homo sapiens_hsa049710.60498362
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59481357
97Circadian entrainment_Homo sapiens_hsa047130.59444620
98Sulfur relay system_Homo sapiens_hsa041220.58975954
99Calcium signaling pathway_Homo sapiens_hsa040200.57180837
100Insulin secretion_Homo sapiens_hsa049110.57050717
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55680338
102Purine metabolism_Homo sapiens_hsa002300.55227732
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54499435
104Fructose and mannose metabolism_Homo sapiens_hsa000510.53219017
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51150063
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48973386
107Glutathione metabolism_Homo sapiens_hsa004800.48866847
108Synaptic vesicle cycle_Homo sapiens_hsa047210.47365366
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47093817
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46823920
111Renin secretion_Homo sapiens_hsa049240.45787014
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45763390
113Cholinergic synapse_Homo sapiens_hsa047250.45232960
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42645362
115Morphine addiction_Homo sapiens_hsa050320.41664585
116Staphylococcus aureus infection_Homo sapiens_hsa051500.40745459
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40459957
118Pyrimidine metabolism_Homo sapiens_hsa002400.39822470
119Prion diseases_Homo sapiens_hsa050200.38829094
120Thyroid hormone synthesis_Homo sapiens_hsa049180.38549732
121Hippo signaling pathway_Homo sapiens_hsa043900.38235846
122Nucleotide excision repair_Homo sapiens_hsa034200.37485938
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37133789
124Dopaminergic synapse_Homo sapiens_hsa047280.37108390
125Taste transduction_Homo sapiens_hsa047420.35802861
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35623236
127Pancreatic secretion_Homo sapiens_hsa049720.34825680
128Cocaine addiction_Homo sapiens_hsa050300.34682116
129Galactose metabolism_Homo sapiens_hsa000520.33445037
130Dorso-ventral axis formation_Homo sapiens_hsa043200.33068653
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31135895
132Metabolic pathways_Homo sapiens_hsa011000.31084586
133Axon guidance_Homo sapiens_hsa043600.29610653
134Olfactory transduction_Homo sapiens_hsa047400.29166209
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28757041

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