CLCN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.58925280
2central nervous system myelination (GO:0022010)4.58925280
3neuron cell-cell adhesion (GO:0007158)4.58291368
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.53146612
5synaptic vesicle exocytosis (GO:0016079)4.25570354
6presynaptic membrane assembly (GO:0097105)4.18525289
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.07314617
8vocalization behavior (GO:0071625)4.06167715
9locomotory exploration behavior (GO:0035641)4.01735795
10presynaptic membrane organization (GO:0097090)3.99097071
11neuronal action potential propagation (GO:0019227)3.99070686
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.96967848
13synaptic vesicle maturation (GO:0016188)3.91303697
14regulation of synaptic vesicle exocytosis (GO:2000300)3.90377132
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.89086261
16glutamate secretion (GO:0014047)3.81425651
17ionotropic glutamate receptor signaling pathway (GO:0035235)3.80332987
18protein localization to synapse (GO:0035418)3.77379419
19negative regulation of neurotransmitter transport (GO:0051589)3.76099892
20transmission of nerve impulse (GO:0019226)3.67916364
21negative regulation of neurotransmitter secretion (GO:0046929)3.63575818
22glutamate receptor signaling pathway (GO:0007215)3.58864418
23regulation of glutamate receptor signaling pathway (GO:1900449)3.54566681
24neuron-neuron synaptic transmission (GO:0007270)3.49817350
25synaptic transmission, glutamatergic (GO:0035249)3.47239252
26gamma-aminobutyric acid transport (GO:0015812)3.44381892
27gamma-aminobutyric acid signaling pathway (GO:0007214)3.44145874
28neuron recognition (GO:0008038)3.41997979
29neurotransmitter secretion (GO:0007269)3.33496655
30regulation of synaptic vesicle transport (GO:1902803)3.32759275
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.32461638
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30791496
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28943878
34L-amino acid import (GO:0043092)3.26767359
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.24040751
36regulation of neuronal synaptic plasticity (GO:0048168)3.23167975
37dendritic spine morphogenesis (GO:0060997)3.22397639
38fatty acid elongation (GO:0030497)3.20692165
39sodium ion export (GO:0071436)3.19463900
40long-chain fatty acid biosynthetic process (GO:0042759)3.17941600
41exploration behavior (GO:0035640)3.16919368
42cellular potassium ion homeostasis (GO:0030007)3.16458388
43cell communication by electrical coupling (GO:0010644)3.15911854
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.12267551
45layer formation in cerebral cortex (GO:0021819)3.10867865
46neurotransmitter-gated ion channel clustering (GO:0072578)3.10716725
47long-term synaptic potentiation (GO:0060291)3.07349329
48positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07243776
49long-term memory (GO:0007616)3.04942052
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04843757
51neurotransmitter transport (GO:0006836)3.04790680
52adult walking behavior (GO:0007628)3.03376507
53regulation of postsynaptic membrane potential (GO:0060078)3.02526760
54axonal fasciculation (GO:0007413)3.01278761
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01252121
56cerebellar granule cell differentiation (GO:0021707)3.00710111
57nerve growth factor signaling pathway (GO:0038180)2.99623953
58apical protein localization (GO:0045176)2.93956497
59myelination (GO:0042552)2.91822454
60positive regulation of membrane potential (GO:0045838)2.90978532
61dendrite morphogenesis (GO:0048813)2.90445901
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.89831818
63establishment of mitochondrion localization (GO:0051654)2.89546695
64axon ensheathment (GO:0008366)2.89279681
65ensheathment of neurons (GO:0007272)2.89279681
66regulation of vesicle fusion (GO:0031338)2.88880139
67startle response (GO:0001964)2.88324302
68cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.87650165
69postsynaptic membrane organization (GO:0001941)2.87227296
70regulation of dendritic spine morphogenesis (GO:0061001)2.87095426
71membrane hyperpolarization (GO:0060081)2.86709443
72glycine transport (GO:0015816)2.83533313
73desmosome organization (GO:0002934)2.82531258
74cerebellar Purkinje cell differentiation (GO:0021702)2.80843887
75mating behavior (GO:0007617)2.80083750
76regulation of synaptic transmission, glutamatergic (GO:0051966)2.79196970
77positive regulation of synapse assembly (GO:0051965)2.77461712
78synapse assembly (GO:0007416)2.76871075
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.76847819
80neuronal ion channel clustering (GO:0045161)2.75842955
81regulation of synaptic plasticity (GO:0048167)2.75381165
82regulation of neurotransmitter secretion (GO:0046928)2.74885921
83response to histamine (GO:0034776)2.74527720
84auditory behavior (GO:0031223)2.70761926
85amino acid import (GO:0043090)2.69580163
86synaptic vesicle endocytosis (GO:0048488)2.69567224
87response to methylmercury (GO:0051597)2.69411000
88establishment of nucleus localization (GO:0040023)2.68006528
89cell communication involved in cardiac conduction (GO:0086065)2.66322496
90regulation of neurotransmitter levels (GO:0001505)2.65929923
91learning (GO:0007612)2.64903624
92proline transport (GO:0015824)2.64690780
93regulation of synaptic transmission, GABAergic (GO:0032228)2.64622284
94vesicle transport along microtubule (GO:0047496)2.63755482
95regulation of voltage-gated calcium channel activity (GO:1901385)2.63069152
96positive regulation of synaptic transmission, GABAergic (GO:0032230)2.60701946
97synaptic vesicle docking involved in exocytosis (GO:0016081)2.60526907
98organelle transport along microtubule (GO:0072384)2.60390013
99negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.60293244
100membrane depolarization (GO:0051899)2.59843559
101potassium ion homeostasis (GO:0055075)2.59016153
102negative regulation of dendrite morphogenesis (GO:0050774)2.58430671
103synapse organization (GO:0050808)2.58359492
104mechanosensory behavior (GO:0007638)2.58200417
105response to auditory stimulus (GO:0010996)2.58064677
106cytoskeletal anchoring at plasma membrane (GO:0007016)2.57955035
107regulation of dendritic spine development (GO:0060998)2.57739656
108negative regulation of synaptic transmission (GO:0050805)2.57366465
109asymmetric protein localization (GO:0008105)2.56960107
110macroautophagy (GO:0016236)2.55192562
111cellular sodium ion homeostasis (GO:0006883)2.53658631
112calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.50328444
113righting reflex (GO:0060013)2.49812493
114regulation of clathrin-mediated endocytosis (GO:2000369)2.48896259
115Golgi to endosome transport (GO:0006895)2.47363858
116regulation of cAMP-dependent protein kinase activity (GO:2000479)2.43095542
117detection of calcium ion (GO:0005513)2.41442273
118regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.38603856
119positive regulation of potassium ion transport (GO:0043268)2.35192099
120embryonic retina morphogenesis in camera-type eye (GO:0060059)2.31250936
121dendritic spine organization (GO:0097061)2.25878766
122membrane assembly (GO:0071709)2.25601260
123clathrin coat assembly (GO:0048268)2.25155250
124relaxation of cardiac muscle (GO:0055119)2.24859542
125regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.24050530
126negative regulation of dendrite development (GO:2000171)2.22047706
127cytoplasmic mRNA processing body assembly (GO:0033962)2.21960478
128pyrimidine nucleobase catabolic process (GO:0006208)2.19198481
129nucleobase catabolic process (GO:0046113)2.17453952
130regulation of cell communication by electrical coupling (GO:0010649)2.16566023
131positive regulation of muscle hypertrophy (GO:0014742)2.16547189
132positive regulation of cardiac muscle hypertrophy (GO:0010613)2.16547189
133potassium ion import (GO:0010107)2.15769835
134neurotransmitter uptake (GO:0001504)2.15045129
135regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.13942370
136regulation of protein glycosylation (GO:0060049)2.07323222
137astrocyte differentiation (GO:0048708)2.07300350
138suckling behavior (GO:0001967)2.04775671
139central nervous system projection neuron axonogenesis (GO:0021952)2.03280710
140auditory receptor cell differentiation (GO:0042491)2.02444229
141regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.02270569
142cerebellar Purkinje cell layer development (GO:0021680)2.02219512
143negative regulation of hormone biosynthetic process (GO:0032353)2.02114090
144positive regulation of neurological system process (GO:0031646)2.01292693
145atrial cardiac muscle cell action potential (GO:0086014)2.00600128
146regulation of Rac protein signal transduction (GO:0035020)2.00451608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.27816867
2GBX2_23144817_ChIP-Seq_PC3_Human3.98825122
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66821836
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61038224
5TAF15_26573619_Chip-Seq_HEK293_Human2.52755448
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.49393333
7REST_21632747_ChIP-Seq_MESCs_Mouse2.18580309
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16436962
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12913375
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12235740
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12235740
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10436350
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07947053
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05881090
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05337163
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04187819
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.03492240
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02642787
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95581171
20AR_21572438_ChIP-Seq_LNCaP_Human1.94731770
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93606420
22DROSHA_22980978_ChIP-Seq_HELA_Human1.92762356
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.89738322
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88810659
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88015508
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86761759
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.85749635
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.84501480
29* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84175792
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82946718
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81664308
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.81307270
33* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77881224
34SMAD4_21799915_ChIP-Seq_A2780_Human1.76183800
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75092233
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.74876101
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.73465041
38P300_19829295_ChIP-Seq_ESCs_Human1.69494081
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.67378221
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65070004
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64380265
42NRF2_20460467_ChIP-Seq_MEFs_Mouse1.62809452
43NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.62809452
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60122777
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.57123008
46STAT3_23295773_ChIP-Seq_U87_Human1.49222817
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48736763
48IGF1R_20145208_ChIP-Seq_DFB_Human1.46676903
49VDR_22108803_ChIP-Seq_LS180_Human1.46578619
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.45846530
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44659653
52FUS_26573619_Chip-Seq_HEK293_Human1.44592857
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43206473
54ER_23166858_ChIP-Seq_MCF-7_Human1.42237649
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41915392
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41411486
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37584006
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37314947
59CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36263757
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.34970816
61TCF4_18268006_ChIP-ChIP_LS174T_Human1.34929151
62* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.34457072
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.34086828
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.32784394
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29814745
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29253171
67AR_25329375_ChIP-Seq_VCAP_Human1.29045644
68TCF4_23295773_ChIP-Seq_U87_Human1.28749261
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28732785
70* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25872089
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.25610569
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25007704
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24687302
74ZNF274_21170338_ChIP-Seq_K562_Hela1.24677472
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.23414511
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.22875383
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20048243
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18856332
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17943536
80GATA1_22025678_ChIP-Seq_K562_Human1.17628501
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17219809
82RNF2_27304074_Chip-Seq_NSC_Mouse1.17058603
83AHR_22903824_ChIP-Seq_MCF-7_Human1.17017695
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16882257
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16615003
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13585968
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13517473
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.12932817
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11112741
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09670092
91TP53_16413492_ChIP-PET_HCT116_Human1.09333607
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09292988
93* RUNX2_22187159_ChIP-Seq_PCA_Human1.08845663
94AR_19668381_ChIP-Seq_PC3_Human1.08585978
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.08146629
96TRIM28_21343339_ChIP-Seq_HEK293_Human1.07120294
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06697105
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06580335
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06580335
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.05678522
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.04979678
102YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04586813
103* TAL1_26923725_Chip-Seq_HPCs_Mouse1.04458657
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04255295
105SMAD3_21741376_ChIP-Seq_HESCs_Human1.03990258
106IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03849690
107CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03804765
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02754176
109PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01913454
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01833621
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01510474
112WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01504244
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00154900
114TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99419966
115P53_22387025_ChIP-Seq_ESCs_Mouse0.99013095
116GF1B_26923725_Chip-Seq_HPCs_Mouse0.98997887
117SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97189747
118RING1B_27294783_Chip-Seq_ESCs_Mouse0.95878523
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95353954
120EWS_26573619_Chip-Seq_HEK293_Human0.94911120
121TP53_18474530_ChIP-ChIP_U2OS_Human0.94815530
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.94797648
123KDM2B_26808549_Chip-Seq_REH_Human0.93208067
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92963177
125P300_18555785_Chip-Seq_ESCs_Mouse0.92895130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.87951477
2* MP0004859_abnormal_synaptic_plasticity4.41218447
3MP0004270_analgesia3.74635908
4* MP0003635_abnormal_synaptic_transmissio3.39268488
5* MP0009745_abnormal_behavioral_response2.98206028
6MP0010234_abnormal_vibrissa_follicle2.97982887
7* MP0002064_seizures2.91609459
8MP0009046_muscle_twitch2.87262172
9* MP0002063_abnormal_learning/memory/cond2.73452449
10MP0002272_abnormal_nervous_system2.69135522
11MP0001486_abnormal_startle_reflex2.66585312
12MP0005423_abnormal_somatic_nervous2.58015308
13MP0002734_abnormal_mechanical_nocicepti2.53776035
14MP0001968_abnormal_touch/_nociception2.48446642
15* MP0002572_abnormal_emotion/affect_behav2.47133662
16MP0002735_abnormal_chemical_nociception2.23319978
17MP0001440_abnormal_grooming_behavior2.22726055
18MP0005187_abnormal_penis_morphology2.20481851
19MP0009780_abnormal_chondrocyte_physiolo2.18873677
20MP0000920_abnormal_myelination2.10724999
21MP0000778_abnormal_nervous_system2.10545549
22MP0002822_catalepsy2.08284614
23MP0004885_abnormal_endolymph2.08209829
24MP0002067_abnormal_sensory_capabilities2.00787809
25MP0002736_abnormal_nociception_after1.96520365
26MP0003329_amyloid_beta_deposits1.95178637
27MP0001501_abnormal_sleep_pattern1.90641205
28MP0001529_abnormal_vocalization1.83981775
29MP0002733_abnormal_thermal_nociception1.83597052
30* MP0005551_abnormal_eye_electrophysiolog1.81067601
31MP0005646_abnormal_pituitary_gland1.80532601
32MP0005248_abnormal_Harderian_gland1.79413722
33MP0005386_behavior/neurological_phenoty1.79230031
34MP0004924_abnormal_behavior1.79230031
35MP0001970_abnormal_pain_threshold1.75358471
36MP0004142_abnormal_muscle_tone1.75273982
37MP0001984_abnormal_olfaction1.68402142
38MP0004043_abnormal_pH_regulation1.67449844
39MP0004742_abnormal_vestibular_system1.66722268
40MP0005645_abnormal_hypothalamus_physiol1.65446023
41MP0001905_abnormal_dopamine_level1.62434766
42MP0002557_abnormal_social/conspecific_i1.60045924
43* MP0002229_neurodegeneration1.58112871
44MP0000955_abnormal_spinal_cord1.57017664
45MP0002184_abnormal_innervation1.56866253
46MP0000569_abnormal_digit_pigmentation1.55247594
47MP0002009_preneoplasia1.54077163
48* MP0002882_abnormal_neuron_morphology1.52061118
49MP0000566_synostosis1.51225862
50* MP0008569_lethality_at_weaning1.51131815
51MP0002877_abnormal_melanocyte_morpholog1.49299463
52MP0003656_abnormal_erythrocyte_physiolo1.48161722
53MP0001502_abnormal_circadian_rhythm1.46048511
54MP0002909_abnormal_adrenal_gland1.42821742
55MP0006276_abnormal_autonomic_nervous1.40162403
56* MP0002066_abnormal_motor_capabilities/c1.39399278
57MP0004215_abnormal_myocardial_fiber1.38796067
58* MP0003690_abnormal_glial_cell1.37937912
59* MP0003634_abnormal_glial_cell1.37688128
60MP0006072_abnormal_retinal_apoptosis1.33455036
61MP0004811_abnormal_neuron_physiology1.33353116
62MP0001485_abnormal_pinna_reflex1.31882253
63MP0001188_hyperpigmentation1.28516099
64* MP0003633_abnormal_nervous_system1.28039664
65MP0005171_absent_coat_pigmentation1.25706581
66MP0003787_abnormal_imprinting1.24998977
67* MP0003631_nervous_system_phenotype1.24721405
68MP0002876_abnormal_thyroid_physiology1.22818058
69MP0004147_increased_porphyrin_level1.21903986
70MP0000647_abnormal_sebaceous_gland1.19681514
71MP0001963_abnormal_hearing_physiology1.17394292
72* MP0003632_abnormal_nervous_system1.12656293
73MP0000383_abnormal_hair_follicle1.11551240
74MP0000631_abnormal_neuroendocrine_gland1.08928344
75MP0003890_abnormal_embryonic-extraembry1.08119443
76* MP0002152_abnormal_brain_morphology1.07378298
77MP0003868_abnormal_feces_composition1.04746807
78MP0004484_altered_response_of1.03778483
79* MP0002752_abnormal_somatic_nervous1.02905006
80MP0010352_gastrointestinal_tract_polyps1.02101666
81MP0005275_abnormal_skin_tensile0.98283054
82* MP0005253_abnormal_eye_physiology0.97363788
83MP0001299_abnormal_eye_distance/0.96453530
84MP0000579_abnormal_nail_morphology0.96396201
85MP0004858_abnormal_nervous_system0.94748308
86MP0003879_abnormal_hair_cell0.93827904
87MP0005409_darkened_coat_color0.92177541
88MP0001177_atelectasis0.91273358
89MP0004272_abnormal_basement_membrane0.90043916
90MP0000013_abnormal_adipose_tissue0.89543100
91MP0003136_yellow_coat_color0.88927263
92MP0000537_abnormal_urethra_morphology0.88705631
93MP0002095_abnormal_skin_pigmentation0.86971320
94MP0004145_abnormal_muscle_electrophysio0.86711213
95MP0000604_amyloidosis0.85613016
96MP0002069_abnormal_eating/drinking_beha0.85562201
97MP0001664_abnormal_digestion0.84048626
98MP0002234_abnormal_pharynx_morphology0.82137061
99MP0002638_abnormal_pupillary_reflex0.82114798
100MP0001879_abnormal_lymphatic_vessel0.80953123
101MP0004084_abnormal_cardiac_muscle0.80314584
102MP0005535_abnormal_body_temperature0.79960417
103MP0003950_abnormal_plasma_membrane0.78823773
104MP0000428_abnormal_craniofacial_morphol0.77694353
105MP0010386_abnormal_urinary_bladder0.77634771
106MP0004085_abnormal_heartbeat0.77080764
107MP0002796_impaired_skin_barrier0.76818582
108MP0003122_maternal_imprinting0.76704822
109MP0003183_abnormal_peptide_metabolism0.76624445
110MP0005174_abnormal_tail_pigmentation0.76046297
111MP0003861_abnormal_nervous_system0.76026283
112MP0000427_abnormal_hair_cycle0.75245863
113MP0000516_abnormal_urinary_system0.74645894
114MP0005367_renal/urinary_system_phenotyp0.74645894
115MP0002233_abnormal_nose_morphology0.74504334
116MP0000377_abnormal_hair_follicle0.73810564
117MP0003941_abnormal_skin_development0.73687624
118MP0008872_abnormal_physiological_respon0.73572677
119MP0000026_abnormal_inner_ear0.72695905
120* MP0005195_abnormal_posterior_eye0.72567428
121MP0002896_abnormal_bone_mineralization0.70197358
122MP0002837_dystrophic_cardiac_calcinosis0.68949124
123* MP0002090_abnormal_vision0.67998363
124MP0000534_abnormal_ureter_morphology0.67518786
125MP0003121_genomic_imprinting0.66305713
126MP0003123_paternal_imprinting0.66052229
127MP0005394_taste/olfaction_phenotype0.65184471
128MP0005499_abnormal_olfactory_system0.65184471
129MP0008874_decreased_physiological_sensi0.63685036
130MP0001986_abnormal_taste_sensitivity0.63052777
131MP0000462_abnormal_digestive_system0.62119490
132MP0001943_abnormal_respiration0.61036610
133MP0003195_calcinosis0.59823742
134MP0001765_abnormal_ion_homeostasis0.57338593
135MP0005379_endocrine/exocrine_gland_phen0.57006354
136MP0003137_abnormal_impulse_conducting0.56641358
137MP0010678_abnormal_skin_adnexa0.56229450

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.14686028
2Myokymia (HP:0002411)4.64014903
3Focal seizures (HP:0007359)4.37029152
4Epileptic encephalopathy (HP:0200134)4.32641986
5Atonic seizures (HP:0010819)4.12287739
6Degeneration of the lateral corticospinal tracts (HP:0002314)3.89510256
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.89510256
8Neurofibrillary tangles (HP:0002185)3.86595294
9Febrile seizures (HP:0002373)3.85264393
10Abnormality of the corticospinal tract (HP:0002492)3.70770557
11Visual hallucinations (HP:0002367)3.58270868
12Papillary thyroid carcinoma (HP:0002895)3.47380027
13Hyperventilation (HP:0002883)3.46393030
14Supranuclear gaze palsy (HP:0000605)3.44191079
15Absence seizures (HP:0002121)3.42748212
16Progressive cerebellar ataxia (HP:0002073)3.37511401
17Cerebral inclusion bodies (HP:0100314)3.32041451
18Dialeptic seizures (HP:0011146)3.30894157
19Ankle clonus (HP:0011448)3.22371009
20Broad-based gait (HP:0002136)3.22325449
21Dysmetria (HP:0001310)3.19941605
22Termporal pattern (HP:0011008)3.18443747
23Insidious onset (HP:0003587)3.18443747
24Dysdiadochokinesis (HP:0002075)3.16147463
25Generalized tonic-clonic seizures (HP:0002069)3.15598561
26Spastic gait (HP:0002064)3.09538471
27Scanning speech (HP:0002168)3.08179777
28Action tremor (HP:0002345)3.06738688
29Intention tremor (HP:0002080)3.01685054
30Pheochromocytoma (HP:0002666)2.88878754
31Gaze-evoked nystagmus (HP:0000640)2.87876328
32Truncal ataxia (HP:0002078)2.85767126
33Excessive salivation (HP:0003781)2.79432875
34Drooling (HP:0002307)2.79432875
35Progressive inability to walk (HP:0002505)2.59657217
36Anxiety (HP:0000739)2.58487103
37Hemiparesis (HP:0001269)2.58304681
38Akinesia (HP:0002304)2.57331035
39Peripheral hypomyelination (HP:0007182)2.51718228
40Sensory axonal neuropathy (HP:0003390)2.48225373
41Epileptiform EEG discharges (HP:0011182)2.47711965
42Neuroendocrine neoplasm (HP:0100634)2.45588914
43Abnormality of binocular vision (HP:0011514)2.45499829
44Diplopia (HP:0000651)2.45499829
45Depression (HP:0000716)2.42249098
46EEG with generalized epileptiform discharges (HP:0011198)2.42230963
47Blue irides (HP:0000635)2.41440741
48Thyroid carcinoma (HP:0002890)2.39762135
49Urinary bladder sphincter dysfunction (HP:0002839)2.37957661
50Generalized myoclonic seizures (HP:0002123)2.36519267
51Increased circulating renin level (HP:0000848)2.36157941
52Curly hair (HP:0002212)2.35722866
53Tetraparesis (HP:0002273)2.31961571
54Hypsarrhythmia (HP:0002521)2.30942708
55Postural instability (HP:0002172)2.30569453
56Impaired vibration sensation in the lower limbs (HP:0002166)2.27906949
57Absent speech (HP:0001344)2.25855602
58Poor eye contact (HP:0000817)2.22688435
59Urinary urgency (HP:0000012)2.20471285
60Hyperinsulinemic hypoglycemia (HP:0000825)2.19696516
61Lower limb muscle weakness (HP:0007340)2.18923244
62Onion bulb formation (HP:0003383)2.18383044
63Abnormal social behavior (HP:0012433)2.17524965
64Impaired social interactions (HP:0000735)2.17524965
65Megalencephaly (HP:0001355)2.17451440
66Gait imbalance (HP:0002141)2.16802822
67Retinal dysplasia (HP:0007973)2.16279842
68Abnormal eating behavior (HP:0100738)2.14318876
69Hypoglycemic coma (HP:0001325)2.14115297
70Bundle branch block (HP:0011710)2.13984023
71Clumsiness (HP:0002312)2.12981171
72Thickened helices (HP:0000391)2.12741851
73Aplasia involving bones of the extremities (HP:0009825)2.07032018
74Aplasia involving bones of the upper limbs (HP:0009823)2.07032018
75Aplasia of the phalanges of the hand (HP:0009802)2.07032018
76Arterial tortuosity (HP:0005116)2.06419426
77Acanthocytosis (HP:0001927)2.04662637
78Protruding tongue (HP:0010808)2.04316338
79Dysmetric saccades (HP:0000641)2.03721177
80Agitation (HP:0000713)2.03492714
81Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.02013421
82Clonus (HP:0002169)2.01361946
83Psychosis (HP:0000709)2.00227198
84Poikilocytosis (HP:0004447)2.00113592
85Widely spaced teeth (HP:0000687)1.98419378
86Cubitus valgus (HP:0002967)1.95588381
87Abnormality of salivation (HP:0100755)1.95479988
88Hepatoblastoma (HP:0002884)1.95150132
89Limb dystonia (HP:0002451)1.94584789
90Hypoplastic labia majora (HP:0000059)1.94323201
91Genital tract atresia (HP:0001827)1.94102723
92Abnormality of macular pigmentation (HP:0008002)1.93425795
93Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.92847683
94Vaginal atresia (HP:0000148)1.92550786
95Germ cell neoplasia (HP:0100728)1.91990656
96Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90671856
97Right ventricular cardiomyopathy (HP:0011663)1.90195495
98Metabolic alkalosis (HP:0200114)1.89508053
99Atrioventricular block (HP:0001678)1.88648657
100Inability to walk (HP:0002540)1.88616391
101Specific learning disability (HP:0001328)1.86951604
102Postural tremor (HP:0002174)1.86621646
103Amblyopia (HP:0000646)1.86529845
104Medial flaring of the eyebrow (HP:0010747)1.83968289
105Vertebral arch anomaly (HP:0008438)1.83393276
106Exotropia (HP:0000577)1.82773882
107Syncope (HP:0001279)1.82573842
108Hypoglycemic seizures (HP:0002173)1.81123449
109Gait ataxia (HP:0002066)1.80966179
110Split foot (HP:0001839)1.80908836
111Abnormal biliary tract morphology (HP:0012440)1.80614488
112Morphological abnormality of the pyramidal tract (HP:0002062)1.79396482
113Hammertoe (HP:0001765)1.78946568
114Overgrowth (HP:0001548)1.78906687
115Bradykinesia (HP:0002067)1.78114579
116Mutism (HP:0002300)1.78007286
117Abnormality of permanent molar morphology (HP:0011071)1.77274399
118Abnormality of the dental root (HP:0006486)1.77274399
119Taurodontia (HP:0000679)1.77274399
120Congenital primary aphakia (HP:0007707)1.77203602
121Hypomagnesemia (HP:0002917)1.76094969
122Vascular tortuosity (HP:0004948)1.75928015
123Atrioventricular canal defect (HP:0006695)1.75530184
124Neoplasm of the heart (HP:0100544)1.74702881
125Central scotoma (HP:0000603)1.74615085
126Abnormality of the labia majora (HP:0012881)1.71755800
127Abnormal auditory evoked potentials (HP:0006958)1.69585793
128Status epilepticus (HP:0002133)1.69570936
129Neoplasm of the thyroid gland (HP:0100031)1.69226095
130Decreased motor nerve conduction velocity (HP:0003431)1.68093209
131Genetic anticipation (HP:0003743)1.68075484
132Neuronal loss in central nervous system (HP:0002529)1.67584670
133Fetal akinesia sequence (HP:0001989)1.67369533
134Heart block (HP:0012722)1.67352818
135Abnormality of secondary sexual hair (HP:0009888)1.66595579
136Abnormality of the axillary hair (HP:0100134)1.66595579
137White forelock (HP:0002211)1.65806008
138Gastroesophageal reflux (HP:0002020)1.64885429
139Impaired vibratory sensation (HP:0002495)1.63778308
140Abnormality of molar (HP:0011077)1.62982610
141Abnormality of molar morphology (HP:0011070)1.62982610
142Biliary tract neoplasm (HP:0100574)1.62304040
143Neonatal short-limb short stature (HP:0008921)1.61683219
144Alacrima (HP:0000522)1.61491990
145Open mouth (HP:0000194)1.61316851
146Bladder carcinoma (HP:0002862)1.59842905
147Bladder neoplasm (HP:0009725)1.59842905
148Ventricular fibrillation (HP:0001663)1.59824231
149Hamartoma (HP:0010566)1.59501290
150Hyporeflexia of lower limbs (HP:0002600)1.58919048
151Patchy hypopigmentation of hair (HP:0011365)1.58280557
152Transitional cell carcinoma of the bladder (HP:0006740)1.56674925
153Macroorchidism (HP:0000053)1.56292060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.37344148
2EPHA43.28946446
3STK393.15684943
4MARK12.93041084
5CASK2.87768588
6OXSR12.82298488
7MAP3K42.66476537
8MAP3K92.33396800
9MAP2K72.10698348
10STK242.03446822
11PNCK2.02532530
12PRPF4B1.99740452
13TNIK1.93449625
14NTRK21.72228783
15ERBB31.72047917
16NTRK11.72030371
17WNK41.66648649
18PAK61.65680407
19BCR1.63447666
20LMTK21.62583142
21MINK11.61155104
22MAP3K21.57605598
23EPHA31.54033367
24SGK2231.53344028
25SGK4941.53344028
26EIF2AK11.52964569
27UHMK11.51190963
28WNK11.46708705
29STK38L1.44851239
30CDK191.41803759
31CDK51.38685065
32DAPK21.37996690
33PKN11.34283868
34MAP2K41.32320535
35CAMK2B1.29131186
36MAPKAPK51.28994555
37KSR21.25192899
38AKT31.23103655
39MAPK131.22517824
40LATS21.21355047
41WNK31.20234868
42PLK21.18707868
43STK31.17927993
44CAMKK21.16125162
45LATS11.14210641
46FGFR21.12773398
47NEK61.12302249
48GRK51.09527115
49RIPK41.09147280
50CSNK1G21.06900478
51* CAMK2A1.06664330
52EPHB21.04764308
53YES11.04662525
54PDGFRA1.02443045
55PAK31.00061968
56PHKG20.98661706
57PHKG10.98661706
58INSRR0.98220212
59MAP3K120.97783217
60CAMK2D0.95608094
61CAMK1D0.94872341
62KSR10.94136370
63PRKCG0.91305988
64SGK20.91165740
65PRKCE0.90469269
66ICK0.88863769
67FGFR30.88163811
68FGR0.84456842
69MST1R0.84146338
70SGK10.83671468
71CSNK1A1L0.81410266
72MUSK0.80096210
73DYRK1A0.79556753
74STK110.79407321
75TRIM280.78027270
76PRKD30.77756671
77CSNK1G30.75655404
78CAMKK10.75375464
79FRK0.74457042
80CDK140.71348570
81CAMK2G0.71078262
82MAP3K130.70293758
83ROCK20.70029205
84CDK30.69385794
85TYRO30.69259188
86GRK70.68677010
87NEK90.67389691
88PDGFRB0.67302477
89TRPM70.67176521
90CDK180.67082696
91MARK20.66674870
92CDK150.66621478
93NLK0.66308616
94RIPK10.66253861
95CAMK1G0.65525965
96ERBB20.65115035
97PDPK10.64609581
98SGK30.63640269
99BMPR20.62880171
100PRKCH0.61276678
101FES0.60361404
102EEF2K0.60087427
103RPS6KB10.58808085
104EPHB10.56560761
105ERBB40.56430323
106ROCK10.56348113
107STK380.55284993
108RET0.54911617
109CDK11A0.54579271
110TNK20.53038150
111PRKAA10.51880832
112PRKCQ0.51618942
113BMPR1B0.51394256
114PDK10.50078868
115DMPK0.49818451
116CSNK1G10.49545286
117PINK10.49491008
118MAPK150.49148740
119BRD40.49092094
120MST40.49037207
121PRKG10.47770941
122BMX0.47453681
123MET0.47049716
124RPS6KA30.46568986
125FYN0.46380942
126PTK20.45977013
127MAPK100.45843879
128ARAF0.44415657
129NME10.44184430
130MAPK120.43600696
131FGFR10.43104114
132FER0.43052700
133MKNK20.43018354
134CSNK1D0.41637874
135PRKACA0.41525811
136CAMK10.40033649
137ACVR1B0.38560714
138EPHA20.36709241

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.34945576
2Synaptic vesicle cycle_Homo sapiens_hsa047212.66285980
3GABAergic synapse_Homo sapiens_hsa047272.60879295
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.51574539
5Glutamatergic synapse_Homo sapiens_hsa047242.46415581
6Morphine addiction_Homo sapiens_hsa050322.29051709
7Circadian entrainment_Homo sapiens_hsa047132.20949052
8Long-term potentiation_Homo sapiens_hsa047202.18643187
9Olfactory transduction_Homo sapiens_hsa047402.08142503
10Amphetamine addiction_Homo sapiens_hsa050312.02680913
11Collecting duct acid secretion_Homo sapiens_hsa049662.01194300
12Serotonergic synapse_Homo sapiens_hsa047261.91389574
13Phototransduction_Homo sapiens_hsa047441.88284313
14Dopaminergic synapse_Homo sapiens_hsa047281.86896650
15Salivary secretion_Homo sapiens_hsa049701.85997148
16Insulin secretion_Homo sapiens_hsa049111.84307730
17Taste transduction_Homo sapiens_hsa047421.74863664
18Long-term depression_Homo sapiens_hsa047301.72605051
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68116898
20Gastric acid secretion_Homo sapiens_hsa049711.65680518
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65474783
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62365147
23Cholinergic synapse_Homo sapiens_hsa047251.61619022
24Renin secretion_Homo sapiens_hsa049241.53740922
25Cocaine addiction_Homo sapiens_hsa050301.50308047
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38397764
27Vibrio cholerae infection_Homo sapiens_hsa051101.34664838
28Axon guidance_Homo sapiens_hsa043601.33453459
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32926191
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29885126
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28221153
32Calcium signaling pathway_Homo sapiens_hsa040201.25777870
33Oxytocin signaling pathway_Homo sapiens_hsa049211.21946354
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21936595
35Steroid biosynthesis_Homo sapiens_hsa001001.19764748
36Fatty acid elongation_Homo sapiens_hsa000621.19250681
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19243347
38Adherens junction_Homo sapiens_hsa045201.15443788
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14938365
40Ether lipid metabolism_Homo sapiens_hsa005651.14469955
41Sulfur metabolism_Homo sapiens_hsa009201.14044835
42Pancreatic secretion_Homo sapiens_hsa049721.13202040
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09281667
44GnRH signaling pathway_Homo sapiens_hsa049121.08154165
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03852998
46Histidine metabolism_Homo sapiens_hsa003401.03408744
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02336725
48Gap junction_Homo sapiens_hsa045401.02168244
49cAMP signaling pathway_Homo sapiens_hsa040241.01695780
50Type II diabetes mellitus_Homo sapiens_hsa049301.01501749
51Butanoate metabolism_Homo sapiens_hsa006501.00348582
52Endometrial cancer_Homo sapiens_hsa052130.99328777
53ErbB signaling pathway_Homo sapiens_hsa040120.96645688
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91043540
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.89606276
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89311948
57Oxidative phosphorylation_Homo sapiens_hsa001900.87749615
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86530000
59Dorso-ventral axis formation_Homo sapiens_hsa043200.83908402
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83833013
61Hippo signaling pathway_Homo sapiens_hsa043900.83485946
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82515097
63Cardiac muscle contraction_Homo sapiens_hsa042600.78907776
64Alzheimers disease_Homo sapiens_hsa050100.78843981
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78621526
66Estrogen signaling pathway_Homo sapiens_hsa049150.78520366
67Thyroid hormone synthesis_Homo sapiens_hsa049180.77459342
68ECM-receptor interaction_Homo sapiens_hsa045120.77330973
69Melanogenesis_Homo sapiens_hsa049160.76888321
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76186518
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75369666
72AMPK signaling pathway_Homo sapiens_hsa041520.75155791
73Hedgehog signaling pathway_Homo sapiens_hsa043400.74103599
74Choline metabolism in cancer_Homo sapiens_hsa052310.72486640
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72229166
76Arginine and proline metabolism_Homo sapiens_hsa003300.72137302
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69591703
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68816846
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.68717523
80Sphingolipid metabolism_Homo sapiens_hsa006000.68573114
81Fatty acid metabolism_Homo sapiens_hsa012120.67204805
82Fatty acid biosynthesis_Homo sapiens_hsa000610.65272075
83Protein digestion and absorption_Homo sapiens_hsa049740.64264844
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63448366
85Oocyte meiosis_Homo sapiens_hsa041140.63320979
86Inositol phosphate metabolism_Homo sapiens_hsa005620.62860116
87mTOR signaling pathway_Homo sapiens_hsa041500.61641190
88Glioma_Homo sapiens_hsa052140.61452241
89Vitamin B6 metabolism_Homo sapiens_hsa007500.61364392
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60399721
91Arginine biosynthesis_Homo sapiens_hsa002200.59988990
92Ovarian steroidogenesis_Homo sapiens_hsa049130.59762021
93Insulin signaling pathway_Homo sapiens_hsa049100.59715435
94Renal cell carcinoma_Homo sapiens_hsa052110.59623117
95Nitrogen metabolism_Homo sapiens_hsa009100.58686556
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58501668
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.58231976
98beta-Alanine metabolism_Homo sapiens_hsa004100.57451386
99Ras signaling pathway_Homo sapiens_hsa040140.57209767
100MAPK signaling pathway_Homo sapiens_hsa040100.55993753
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55749798
102Rap1 signaling pathway_Homo sapiens_hsa040150.54726154
103Circadian rhythm_Homo sapiens_hsa047100.54327039
104Mineral absorption_Homo sapiens_hsa049780.54238933
105Thyroid cancer_Homo sapiens_hsa052160.54190904
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.54054318
107Bile secretion_Homo sapiens_hsa049760.53855700
108PPAR signaling pathway_Homo sapiens_hsa033200.52634982
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.52622046
110TGF-beta signaling pathway_Homo sapiens_hsa043500.52563138
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52421804
112Alcoholism_Homo sapiens_hsa050340.52007888
113Focal adhesion_Homo sapiens_hsa045100.50560780
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50042610
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49881979
116Tight junction_Homo sapiens_hsa045300.43294128
117Type I diabetes mellitus_Homo sapiens_hsa049400.42584689
118Endocytosis_Homo sapiens_hsa041440.41301443
119Parkinsons disease_Homo sapiens_hsa050120.41198774
120Rheumatoid arthritis_Homo sapiens_hsa053230.38902816
121Dilated cardiomyopathy_Homo sapiens_hsa054140.36813173
122Wnt signaling pathway_Homo sapiens_hsa043100.34922142
123Glucagon signaling pathway_Homo sapiens_hsa049220.33005411
124ABC transporters_Homo sapiens_hsa020100.28742594
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28734135
126Linoleic acid metabolism_Homo sapiens_hsa005910.27592675

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