CLCN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular potassium ion homeostasis (GO:0030007)5.04378640
2neuron cell-cell adhesion (GO:0007158)4.71670469
3sodium ion export (GO:0071436)4.67587130
4axon ensheathment in central nervous system (GO:0032291)4.50795907
5central nervous system myelination (GO:0022010)4.50795907
6presynaptic membrane assembly (GO:0097105)4.43484110
7cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.33235239
8presynaptic membrane organization (GO:0097090)4.29984680
9regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.28488736
10positive regulation of synapse maturation (GO:0090129)4.20579040
11synaptic vesicle exocytosis (GO:0016079)4.19817434
12vocalization behavior (GO:0071625)4.18873133
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.14699473
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.10551319
15regulation of short-term neuronal synaptic plasticity (GO:0048172)4.10455569
16neuronal action potential propagation (GO:0019227)3.90895734
17synaptic vesicle maturation (GO:0016188)3.86055865
18glutamate secretion (GO:0014047)3.84773704
19regulation of synaptic vesicle exocytosis (GO:2000300)3.84144124
20cell communication by electrical coupling (GO:0010644)3.80240114
21protein localization to synapse (GO:0035418)3.78782205
22membrane depolarization during action potential (GO:0086010)3.72317806
23regulation of glutamate receptor signaling pathway (GO:1900449)3.66098748
24positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.65113802
25regulation of cell communication by electrical coupling (GO:0010649)3.64032224
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.63414005
27locomotory exploration behavior (GO:0035641)3.62594071
28potassium ion homeostasis (GO:0055075)3.59594399
29sarcoplasmic reticulum calcium ion transport (GO:0070296)3.59410590
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.59321504
31neuron recognition (GO:0008038)3.53111294
32potassium ion import (GO:0010107)3.44559985
33fatty acid elongation (GO:0030497)3.44109875
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.43501888
35gamma-aminobutyric acid transport (GO:0015812)3.42476772
36regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.41593561
37neurotransmitter-gated ion channel clustering (GO:0072578)3.40589865
38regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.40394913
39regulation of synapse maturation (GO:0090128)3.38515023
40cerebellar Purkinje cell differentiation (GO:0021702)3.38379531
41transmission of nerve impulse (GO:0019226)3.35539648
42postsynaptic membrane organization (GO:0001941)3.33955837
43glutamate receptor signaling pathway (GO:0007215)3.33354723
44positive regulation of dendritic spine development (GO:0060999)3.33211104
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.33070536
46cell communication involved in cardiac conduction (GO:0086065)3.32353208
47regulation of synaptic vesicle transport (GO:1902803)3.31672943
48neuromuscular synaptic transmission (GO:0007274)3.31577401
49dendritic spine morphogenesis (GO:0060997)3.28395804
50negative regulation of neurotransmitter transport (GO:0051589)3.27863955
51regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.27624917
52cellular sodium ion homeostasis (GO:0006883)3.27157546
53synaptic transmission, glutamatergic (GO:0035249)3.26648070
54neuron-neuron synaptic transmission (GO:0007270)3.26561423
55long-chain fatty acid biosynthetic process (GO:0042759)3.25538360
56positive regulation of dendritic spine morphogenesis (GO:0061003)3.20434206
57regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.19741369
58regulation of neuronal synaptic plasticity (GO:0048168)3.19347172
59neuromuscular process controlling balance (GO:0050885)3.18882780
60cerebellar granule cell differentiation (GO:0021707)3.18306478
61negative regulation of dendrite morphogenesis (GO:0050774)3.17240375
62gamma-aminobutyric acid signaling pathway (GO:0007214)3.15583650
63axonal fasciculation (GO:0007413)3.15567326
64exploration behavior (GO:0035640)3.14440476
65neurotransmitter secretion (GO:0007269)3.13896801
66regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.10707545
67positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07259181
68regulation of long-term neuronal synaptic plasticity (GO:0048169)3.03812336
69layer formation in cerebral cortex (GO:0021819)3.02692453
70dendrite morphogenesis (GO:0048813)3.02461015
71amino acid import (GO:0043090)3.02180218
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.01257972
73L-amino acid import (GO:0043092)3.00745492
74regulation of excitatory postsynaptic membrane potential (GO:0060079)3.00493184
75regulation of synapse structural plasticity (GO:0051823)2.99163122
76synaptic vesicle docking involved in exocytosis (GO:0016081)2.97611683
77positive regulation of membrane potential (GO:0045838)2.96943019
78regulation of membrane repolarization (GO:0060306)2.96514635
79long-term synaptic potentiation (GO:0060291)2.94227748
80positive regulation of neurotransmitter transport (GO:0051590)2.93802316
81positive regulation of neurotransmitter secretion (GO:0001956)2.92876054
82negative regulation of neurotransmitter secretion (GO:0046929)2.90223535
83neurotransmitter uptake (GO:0001504)2.90014394
84regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89114573
85establishment of mitochondrion localization (GO:0051654)2.87865137
86adult walking behavior (GO:0007628)2.86474349
87cell differentiation in hindbrain (GO:0021533)2.85886213
88myelination (GO:0042552)2.84858675
89regulation of postsynaptic membrane potential (GO:0060078)2.84045380
90activation of protein kinase A activity (GO:0034199)2.83941744
91regulation of synaptic transmission, glutamatergic (GO:0051966)2.82310323
92axon ensheathment (GO:0008366)2.81636393
93ensheathment of neurons (GO:0007272)2.81636393
94proline transport (GO:0015824)2.79949969
95regulation of dendritic spine morphogenesis (GO:0061001)2.78342223
96neurotransmitter transport (GO:0006836)2.77392347
97long-term memory (GO:0007616)2.76011002
98negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75578901
99auditory behavior (GO:0031223)2.74832748
100positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.73651102
101positive regulation of synapse assembly (GO:0051965)2.72729382
102regulation of neurotransmitter secretion (GO:0046928)2.72688835
103neuronal ion channel clustering (GO:0045161)2.72365843
104pyrimidine nucleobase catabolic process (GO:0006208)2.71254410
105synapse assembly (GO:0007416)2.69938819
106regulation of synaptic plasticity (GO:0048167)2.69040058
107startle response (GO:0001964)2.66215725
108regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.66072021
109regulation of dendritic spine development (GO:0060998)2.63628206
110membrane hyperpolarization (GO:0060081)2.62912498
111mechanosensory behavior (GO:0007638)2.60220708
112membrane assembly (GO:0071709)2.59655598
113negative regulation of axonogenesis (GO:0050771)2.59548216
114regulation of voltage-gated calcium channel activity (GO:1901385)2.58728648
115mating behavior (GO:0007617)2.57792793
116response to auditory stimulus (GO:0010996)2.57424014
117neuron remodeling (GO:0016322)2.57321215
118positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.55643450
119learning (GO:0007612)2.55545277
120cell migration in hindbrain (GO:0021535)2.54961637
121negative regulation of protein localization to cell surface (GO:2000009)2.54711572
122G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.54455613
123regulation of neurotransmitter transport (GO:0051588)2.54034350
124cerebral cortex radially oriented cell migration (GO:0021799)2.53783463
125behavioral response to cocaine (GO:0048148)2.53194940
126membrane depolarization (GO:0051899)2.53017939
127regulation of neurotransmitter levels (GO:0001505)2.52913595
128synapse organization (GO:0050808)2.52438514
129positive regulation of synaptic transmission, GABAergic (GO:0032230)2.52170415
130dendrite development (GO:0016358)2.50817973
131regulation of vesicle fusion (GO:0031338)2.50667700
132negative regulation of axon extension (GO:0030517)2.45857527
133detection of calcium ion (GO:0005513)2.44250303
134regulation of synaptic transmission, GABAergic (GO:0032228)2.42547118
135synaptic vesicle endocytosis (GO:0048488)2.41826911

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.75094248
2GBX2_23144817_ChIP-Seq_PC3_Human3.74014505
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95189679
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89273584
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77145821
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46807175
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46807175
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45318943
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42005825
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40366759
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.38338360
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38197146
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34611275
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34440484
15TAF15_26573619_Chip-Seq_HEK293_Human2.30970522
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.21094864
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.14975884
18REST_21632747_ChIP-Seq_MESCs_Mouse2.14820604
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14421460
20DROSHA_22980978_ChIP-Seq_HELA_Human2.00012787
21AR_21572438_ChIP-Seq_LNCaP_Human1.99063340
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.94527182
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88946909
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85263986
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.83497797
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78326531
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77696455
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77503233
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.77098581
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72592192
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67915566
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67372700
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66533580
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61843858
35RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.61164917
36P300_19829295_ChIP-Seq_ESCs_Human1.57384552
37SMAD4_21799915_ChIP-Seq_A2780_Human1.54165627
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53866654
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51837173
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.50148181
41RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.49125518
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46589365
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46031006
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.44751912
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.42849156
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42148304
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41647065
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41067253
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38559589
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38137801
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37432228
52* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33003849
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31015462
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28523459
55ER_23166858_ChIP-Seq_MCF-7_Human1.28508304
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27933369
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25954610
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.25560445
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25046278
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24976261
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24312752
62VDR_22108803_ChIP-Seq_LS180_Human1.23440451
63AR_25329375_ChIP-Seq_VCAP_Human1.22498741
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19792207
65STAT3_23295773_ChIP-Seq_U87_Human1.19290079
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15934722
67ZNF274_21170338_ChIP-Seq_K562_Hela1.15824519
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15814928
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15809039
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.14694022
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.13818679
72RNF2_27304074_Chip-Seq_NSC_Mouse1.13364940
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13166437
74IGF1R_20145208_ChIP-Seq_DFB_Human1.12347317
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.11157110
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.11056229
77FUS_26573619_Chip-Seq_HEK293_Human1.10831485
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10466577
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10051440
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09954150
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.09471458
82AHR_22903824_ChIP-Seq_MCF-7_Human1.08409612
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08225665
84TCF4_23295773_ChIP-Seq_U87_Human1.04204020
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03910965
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03770926
87* RUNX2_22187159_ChIP-Seq_PCA_Human1.01436503
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01046458
89OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99648262
90KDM2B_26808549_Chip-Seq_K562_Human0.99319856
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99305353
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.99293225
93TET1_21490601_ChIP-Seq_MESCs_Mouse0.99275544
94CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98907522
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98878993
96AR_19668381_ChIP-Seq_PC3_Human0.96404253
97RING1B_27294783_Chip-Seq_NPCs_Mouse0.96098515
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94566216
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94566216
100TP53_18474530_ChIP-ChIP_U2OS_Human0.94132302
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93823608
102KDM2B_26808549_Chip-Seq_REH_Human0.91589422
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91191712
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91053950
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90848217
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89625258
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89625258
108GATA1_26923725_Chip-Seq_HPCs_Mouse0.89495286
109EP300_21415370_ChIP-Seq_HL-1_Mouse0.88294763
110CMYC_18555785_Chip-Seq_ESCs_Mouse0.87135586
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.86750328
112YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86702291
113JUN_21703547_ChIP-Seq_K562_Human0.86379300
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85680469
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85335597
116DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85130102
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84236699
118SOX9_26525672_Chip-Seq_HEART_Mouse0.84231701
119EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83743061
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.82785218
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82602208

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.84190129
2MP0003880_abnormal_central_pattern4.74970492
3MP0004270_analgesia3.57222206
4MP0003635_abnormal_synaptic_transmissio3.48224586
5MP0009745_abnormal_behavioral_response3.03104422
6MP0002064_seizures3.01402283
7MP0002063_abnormal_learning/memory/cond2.85886497
8MP0009046_muscle_twitch2.83442168
9MP0005423_abnormal_somatic_nervous2.67346561
10MP0002272_abnormal_nervous_system2.63136700
11MP0001486_abnormal_startle_reflex2.61647555
12MP0001968_abnormal_touch/_nociception2.60790178
13MP0002734_abnormal_mechanical_nocicepti2.55451614
14MP0002572_abnormal_emotion/affect_behav2.52705694
15MP0002735_abnormal_chemical_nociception2.38205204
16MP0003329_amyloid_beta_deposits2.32558375
17MP0000920_abnormal_myelination2.28948840
18MP0000778_abnormal_nervous_system2.23668156
19MP0002736_abnormal_nociception_after2.19601372
20MP0002822_catalepsy2.11101865
21MP0001529_abnormal_vocalization2.00730618
22MP0001440_abnormal_grooming_behavior1.97277174
23MP0002067_abnormal_sensory_capabilities1.95708139
24MP0009780_abnormal_chondrocyte_physiolo1.94872950
25MP0002733_abnormal_thermal_nociception1.89123120
26MP0001970_abnormal_pain_threshold1.88982174
27MP0001501_abnormal_sleep_pattern1.87584165
28MP0001905_abnormal_dopamine_level1.86225403
29MP0004885_abnormal_endolymph1.79328678
30MP0006276_abnormal_autonomic_nervous1.78862117
31MP0008569_lethality_at_weaning1.72591985
32MP0005386_behavior/neurological_phenoty1.72393492
33MP0004924_abnormal_behavior1.72393492
34MP0000749_muscle_degeneration1.70574468
35MP0003690_abnormal_glial_cell1.70414248
36MP0002184_abnormal_innervation1.68188935
37MP0001984_abnormal_olfaction1.62788444
38MP0004142_abnormal_muscle_tone1.60667133
39MP0004742_abnormal_vestibular_system1.56741467
40MP0000955_abnormal_spinal_cord1.55889706
41MP0002557_abnormal_social/conspecific_i1.55082876
42MP0002882_abnormal_neuron_morphology1.46871189
43MP0003634_abnormal_glial_cell1.46607440
44MP0005646_abnormal_pituitary_gland1.44682434
45MP0002066_abnormal_motor_capabilities/c1.44380874
46MP0004811_abnormal_neuron_physiology1.41940458
47MP0002229_neurodegeneration1.36265272
48MP0003633_abnormal_nervous_system1.33682254
49MP0005551_abnormal_eye_electrophysiolog1.31179385
50MP0002638_abnormal_pupillary_reflex1.30983259
51MP0003631_nervous_system_phenotype1.25885568
52MP0010386_abnormal_urinary_bladder1.23751368
53MP0003123_paternal_imprinting1.23566965
54MP0000604_amyloidosis1.22322342
55MP0001502_abnormal_circadian_rhythm1.21431665
56MP0005645_abnormal_hypothalamus_physiol1.20133383
57MP0003632_abnormal_nervous_system1.17506648
58MP0002909_abnormal_adrenal_gland1.17195863
59MP0003646_muscle_fatigue1.16378576
60MP0002837_dystrophic_cardiac_calcinosis1.15904554
61MP0004858_abnormal_nervous_system1.10787786
62MP0005171_absent_coat_pigmentation1.09279768
63MP0004043_abnormal_pH_regulation1.07053057
64MP0000751_myopathy1.06564566
65MP0001963_abnormal_hearing_physiology1.06156378
66MP0002106_abnormal_muscle_physiology1.04192506
67MP0003879_abnormal_hair_cell1.01918048
68MP0005620_abnormal_muscle_contractility1.01396338
69MP0001188_hyperpigmentation1.00463043
70MP0004084_abnormal_cardiac_muscle0.99406215
71MP0004510_myositis0.99130873
72MP0002152_abnormal_brain_morphology0.98824670
73MP0002090_abnormal_vision0.98745159
74MP0000013_abnormal_adipose_tissue0.97317330
75MP0004145_abnormal_muscle_electrophysio0.95257043
76MP0004087_abnormal_muscle_fiber0.95192004
77MP0005409_darkened_coat_color0.94694835
78MP0002752_abnormal_somatic_nervous0.94405051
79MP0001485_abnormal_pinna_reflex0.92295621
80MP0002332_abnormal_exercise_endurance0.91779990
81MP0001177_atelectasis0.90673825
82MP0000759_abnormal_skeletal_muscle0.90416070
83MP0002069_abnormal_eating/drinking_beha0.87223896
84MP0002876_abnormal_thyroid_physiology0.86035594
85MP0005369_muscle_phenotype0.85175326
86MP0004085_abnormal_heartbeat0.80918970
87MP0003787_abnormal_imprinting0.80001032
88MP0005535_abnormal_body_temperature0.78883790
89MP0001299_abnormal_eye_distance/0.75433376
90MP0001664_abnormal_digestion0.73856460
91MP0002972_abnormal_cardiac_muscle0.73479656
92MP0003121_genomic_imprinting0.73268755
93MP0000631_abnormal_neuroendocrine_gland0.72716510
94MP0008874_decreased_physiological_sensi0.72069996
95MP0003183_abnormal_peptide_metabolism0.71198266
96MP0002269_muscular_atrophy0.71167050
97MP0003195_calcinosis0.70077291
98MP0001986_abnormal_taste_sensitivity0.69354148
99MP0000026_abnormal_inner_ear0.68945520
100MP0005623_abnormal_meninges_morphology0.67014158
101MP0003137_abnormal_impulse_conducting0.66425399
102MP0008877_abnormal_DNA_methylation0.66303151
103MP0003122_maternal_imprinting0.66201859
104MP0004036_abnormal_muscle_relaxation0.65806309
105MP0006072_abnormal_retinal_apoptosis0.64115157
106MP0000750_abnormal_muscle_regeneration0.63642218
107MP0004134_abnormal_chest_morphology0.62453935
108MP0005167_abnormal_blood-brain_barrier0.60215690
109MP0005253_abnormal_eye_physiology0.59307187
110MP0005195_abnormal_posterior_eye0.59070068
111MP0004130_abnormal_muscle_cell0.57723431
112MP0001346_abnormal_lacrimal_gland0.57050104
113MP0001943_abnormal_respiration0.56529015
114MP0000747_muscle_weakness0.55664796
115MP0004484_altered_response_of0.55138048
116MP0003075_altered_response_to0.54878429
117MP0008872_abnormal_physiological_respon0.54500625
118MP0004215_abnormal_myocardial_fiber0.50337996
119MP0005410_abnormal_fertilization0.49069006
120MP0004147_increased_porphyrin_level0.47459878

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.80792310
2Myokymia (HP:0002411)4.95942434
3Neurofibrillary tangles (HP:0002185)4.68468655
4Epileptic encephalopathy (HP:0200134)4.28592490
5Focal seizures (HP:0007359)4.13945676
6Muscle fiber inclusion bodies (HP:0100299)4.12677740
7Atonic seizures (HP:0010819)4.07766200
8Supranuclear gaze palsy (HP:0000605)4.04695906
9Nemaline bodies (HP:0003798)4.02417422
10Hyperventilation (HP:0002883)3.99866031
11Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.96550967
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.95657632
13Degeneration of the lateral corticospinal tracts (HP:0002314)3.95657632
14Abnormality of the corticospinal tract (HP:0002492)3.90809620
15Cerebral inclusion bodies (HP:0100314)3.84109334
16Exercise-induced muscle cramps (HP:0003710)3.61536369
17Visual hallucinations (HP:0002367)3.54403454
18Exercise-induced myalgia (HP:0003738)3.37048643
19Insidious onset (HP:0003587)3.25421885
20Termporal pattern (HP:0011008)3.25421885
21Febrile seizures (HP:0002373)3.23001160
22Progressive cerebellar ataxia (HP:0002073)3.20999189
23Bundle branch block (HP:0011710)3.19036162
24Broad-based gait (HP:0002136)3.17379955
25Ankle clonus (HP:0011448)3.12323962
26Absence seizures (HP:0002121)3.11334803
27Spastic gait (HP:0002064)3.11111588
28Pheochromocytoma (HP:0002666)3.09412206
29Action tremor (HP:0002345)3.07331298
30Progressive inability to walk (HP:0002505)3.00752413
31Dysmetria (HP:0001310)2.99614073
32Dialeptic seizures (HP:0011146)2.98286176
33Intention tremor (HP:0002080)2.90766285
34Akinesia (HP:0002304)2.90183186
35Generalized tonic-clonic seizures (HP:0002069)2.90101874
36Difficulty running (HP:0009046)2.89057395
37Scanning speech (HP:0002168)2.86692138
38Sudden death (HP:0001699)2.85726976
39Type 1 muscle fiber predominance (HP:0003803)2.82821512
40Limb dystonia (HP:0002451)2.81702213
41Hyporeflexia of lower limbs (HP:0002600)2.78457519
42Neuroendocrine neoplasm (HP:0100634)2.76070673
43Muscle hypertrophy of the lower extremities (HP:0008968)2.70697776
44Abnormal eating behavior (HP:0100738)2.69842148
45EMG: myopathic abnormalities (HP:0003458)2.67915933
46Anxiety (HP:0000739)2.63545395
47Muscle fiber splitting (HP:0003555)2.61446133
48Sensory axonal neuropathy (HP:0003390)2.58148630
49Calf muscle hypertrophy (HP:0008981)2.56622147
50Mutism (HP:0002300)2.55618214
51Excessive salivation (HP:0003781)2.54665669
52Drooling (HP:0002307)2.54665669
53Truncal ataxia (HP:0002078)2.53770628
54Frequent falls (HP:0002359)2.52448997
55Peripheral hypomyelination (HP:0007182)2.47427084
56Status epilepticus (HP:0002133)2.47148716
57Polyphagia (HP:0002591)2.44716164
58Cerebral hypomyelination (HP:0006808)2.44376146
59Hemiplegia (HP:0002301)2.43747138
60Myotonia (HP:0002486)2.43185166
61Ventricular fibrillation (HP:0001663)2.42709105
62Retinal dysplasia (HP:0007973)2.42366511
63Dysdiadochokinesis (HP:0002075)2.42053932
64Lower limb amyotrophy (HP:0007210)2.39432623
65Thickened helices (HP:0000391)2.39296854
66Gaze-evoked nystagmus (HP:0000640)2.37375291
67Tetraplegia (HP:0002445)2.37246871
68Megalencephaly (HP:0001355)2.36744215
69Poor eye contact (HP:0000817)2.36555777
70Amblyopia (HP:0000646)2.36229420
71Impaired vibration sensation in the lower limbs (HP:0002166)2.34910613
72EMG: neuropathic changes (HP:0003445)2.34762548
73Blue irides (HP:0000635)2.34224354
74Depression (HP:0000716)2.34132818
75Urinary urgency (HP:0000012)2.33080263
76Heart block (HP:0012722)2.29564730
77Papilledema (HP:0001085)2.29514123
78Lower limb muscle weakness (HP:0007340)2.29422403
79Distal arthrogryposis (HP:0005684)2.27981950
80Inability to walk (HP:0002540)2.27541749
81Generalized myoclonic seizures (HP:0002123)2.26302701
82Epileptiform EEG discharges (HP:0011182)2.25773508
83Urinary bladder sphincter dysfunction (HP:0002839)2.25066537
84Obstructive sleep apnea (HP:0002870)2.23949796
85Torticollis (HP:0000473)2.23765603
86Abnormality of the calf musculature (HP:0001430)2.23685698
87Dysmetric saccades (HP:0000641)2.22692994
88Increased circulating renin level (HP:0000848)2.22079737
89Abnormality of the lower motor neuron (HP:0002366)2.21904990
90Abnormality of binocular vision (HP:0011514)2.21028975
91Diplopia (HP:0000651)2.21028975
92EEG with generalized epileptiform discharges (HP:0011198)2.17330115
93Abnormal social behavior (HP:0012433)2.14478667
94Impaired social interactions (HP:0000735)2.14478667
95Rimmed vacuoles (HP:0003805)2.14336637
96Onion bulb formation (HP:0003383)2.14240004
97Bradykinesia (HP:0002067)2.12821228
98Hemiparesis (HP:0001269)2.12674919
99Neuronal loss in central nervous system (HP:0002529)2.10841756
100Clonus (HP:0002169)2.09728411
101Impaired vibratory sensation (HP:0002495)2.09399321
102Abnormality of the foot musculature (HP:0001436)2.08434699
103Absent speech (HP:0001344)2.08359227
104Foot dorsiflexor weakness (HP:0009027)2.08317148
105Hypsarrhythmia (HP:0002521)2.08182428
106Syncope (HP:0001279)2.07491805
107Prolonged QT interval (HP:0001657)2.07314251
108Focal dystonia (HP:0004373)2.07058353
109Rapidly progressive (HP:0003678)2.06949462
110Abnormal atrioventricular conduction (HP:0005150)2.06400289
111Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.05307758
112Acute necrotizing encephalopathy (HP:0006965)2.04844974
113Myopathic facies (HP:0002058)2.03073625
114Centrally nucleated skeletal muscle fibers (HP:0003687)2.01656883
115Fetal akinesia sequence (HP:0001989)2.00461243
116Incomplete penetrance (HP:0003829)1.98216382
117Aplasia involving bones of the extremities (HP:0009825)1.96986024
118Aplasia involving bones of the upper limbs (HP:0009823)1.96986024
119Aplasia of the phalanges of the hand (HP:0009802)1.96986024
120Sleep apnea (HP:0010535)1.96947598
121Rigidity (HP:0002063)1.95837892
122Craniofacial dystonia (HP:0012179)1.95114479
123Gait imbalance (HP:0002141)1.94790007
124Leukodystrophy (HP:0002415)1.94379218
125Parakeratosis (HP:0001036)1.93985977
126Hypoplasia of the brainstem (HP:0002365)1.92568952
127Aplasia/Hypoplasia of the brainstem (HP:0007362)1.92568952
128Type II lissencephaly (HP:0007260)1.91978252
129Progressive macrocephaly (HP:0004481)1.91692615
130Cerebral hemorrhage (HP:0001342)1.91435592
131Postural instability (HP:0002172)1.90479582
132Psychosis (HP:0000709)1.89498128
133Morphological abnormality of the pyramidal tract (HP:0002062)1.89036216
134Abnormal mitochondria in muscle tissue (HP:0008316)1.87222714
135Agitation (HP:0000713)1.81776369
136Increased serum pyruvate (HP:0003542)1.80722232
137Abnormality of glycolysis (HP:0004366)1.80722232
138Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.80687987
139Abnormality of salivation (HP:0100755)1.78534827
140Stereotypic behavior (HP:0000733)1.76170032
141Clumsiness (HP:0002312)1.76164565
142Esotropia (HP:0000565)1.75638462
143Specific learning disability (HP:0001328)1.75479522
144Acute encephalopathy (HP:0006846)1.74581232
145Gait ataxia (HP:0002066)1.74054743
146Slow saccadic eye movements (HP:0000514)1.72774604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.58568232
2CASK3.20831373
3OBSCN3.19370898
4EPHA43.14077663
5STK392.86029493
6OXSR12.73924705
7NTRK32.73079215
8MAP3K42.43003406
9MAP2K72.42996209
10TNIK2.28008389
11MAP3K92.22804630
12CDK192.07382224
13MINK11.96253842
14NTRK21.89018546
15DAPK21.82222526
16PAK61.68869080
17NTRK11.68630718
18PRPF4B1.59683373
19PNCK1.55417597
20MAP2K41.53601212
21MAPK131.50149857
22LATS21.46450633
23SGK4941.43678675
24SGK2231.43678675
25PKN11.43417200
26CDK51.42625871
27WNK41.40523496
28BCR1.36886646
29UHMK11.36725340
30PHKG21.35469610
31PHKG11.35469610
32PLK21.30330999
33CAMK2B1.27871941
34MAP3K121.26354578
35FGFR21.15923130
36CSNK1G21.14510463
37KSR21.12462856
38RIPK41.12174227
39CAMK2A1.10602652
40FES1.07360688
41RIPK11.07188665
42GRK51.06257575
43EPHB11.03197128
44PAK31.02453452
45ARAF1.00511350
46KSR10.99593262
47MAPKAPK50.98048204
48TTN0.97269800
49SGK30.93916381
50CSNK1G30.93797732
51CAMK2D0.92695248
52DYRK20.91678736
53PRKCE0.90532337
54PRKCG0.90529442
55WNK10.90359771
56FGR0.87134655
57CDK140.85848150
58CAMKK20.85536958
59CDK180.85135508
60MUSK0.83250982
61CDK150.82905327
62DYRK1A0.82607600
63MARK20.81119698
64NEK60.79260431
65TYRO30.79129431
66LIMK10.78072922
67PRKCH0.77424000
68SIK20.76571630
69CSNK1A1L0.75516910
70ROCK20.75018584
71BMPR1B0.74101042
72MAP3K130.73821833
73CAMK2G0.72665026
74MAP3K20.72531710
75CAMKK10.72310775
76CDK11A0.71405318
77MAPK100.70900521
78STK380.68954643
79PRKD30.68810289
80CAMK40.68729571
81SGK20.68159871
82CCNB10.66613852
83BMPR20.66053420
84DAPK10.65444150
85ALK0.63387097
86WNK30.62439000
87RPS6KA30.61845557
88FYN0.61077291
89CSNK1G10.60805787
90PTK2B0.60795352
91MAPK120.60332685
92CAMK1G0.57538957
93STK110.57406459
94MAPK150.56713286
95RET0.55702102
96PDPK10.55636331
97PINK10.54642787
98SGK10.54421442
99DMPK0.53130910
100PRKCQ0.52568275
101CAMK10.50027024
102ERBB30.49148393
103GRK70.47717201
104PRKCZ0.45750362
105PRKAA10.44756513
106NME10.44590346
107INSRR0.44485243
108MAPK70.44133101
109MAP3K70.44046842
110ROCK10.43721384
111PIK3CA0.43590617
112PRKG10.43223983
113PRKACA0.43077817
114PDK10.42297871
115TRIM280.41356377
116LMTK20.40679309
117BRAF0.38746046
118RAF10.37625548
119CSNK1D0.36638500
120RPS6KB10.33467858
121MOS0.33035803
122PRKCA0.32191049
123MAP2K10.32160323
124MAPK40.30349472
125DAPK30.29358077

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.04510291
2Synaptic vesicle cycle_Homo sapiens_hsa047212.85857832
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45483592
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41627758
5GABAergic synapse_Homo sapiens_hsa047272.41551228
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19278699
7Glutamatergic synapse_Homo sapiens_hsa047242.17618657
8Circadian entrainment_Homo sapiens_hsa047132.17171318
9Morphine addiction_Homo sapiens_hsa050322.14772181
10Collecting duct acid secretion_Homo sapiens_hsa049662.06793679
11Olfactory transduction_Homo sapiens_hsa047402.04461859
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87681319
13Dopaminergic synapse_Homo sapiens_hsa047281.77811515
14Amphetamine addiction_Homo sapiens_hsa050311.77726581
15Long-term potentiation_Homo sapiens_hsa047201.74169208
16Serotonergic synapse_Homo sapiens_hsa047261.71706798
17Salivary secretion_Homo sapiens_hsa049701.61217213
18Cholinergic synapse_Homo sapiens_hsa047251.59296482
19Taste transduction_Homo sapiens_hsa047421.55416423
20Steroid biosynthesis_Homo sapiens_hsa001001.54741315
21Fatty acid elongation_Homo sapiens_hsa000621.53049335
22Long-term depression_Homo sapiens_hsa047301.50682074
23Axon guidance_Homo sapiens_hsa043601.48338223
24Oxidative phosphorylation_Homo sapiens_hsa001901.45992841
25Insulin secretion_Homo sapiens_hsa049111.45382578
26Cocaine addiction_Homo sapiens_hsa050301.44816981
27Butanoate metabolism_Homo sapiens_hsa006501.40457505
28Vibrio cholerae infection_Homo sapiens_hsa051101.39788259
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39239193
30Gastric acid secretion_Homo sapiens_hsa049711.38083345
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34771605
32Renin secretion_Homo sapiens_hsa049241.34410409
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34199625
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.28672088
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22767049
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21340512
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19133580
38Oxytocin signaling pathway_Homo sapiens_hsa049211.16355794
39Alzheimers disease_Homo sapiens_hsa050101.15240444
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13842361
41Calcium signaling pathway_Homo sapiens_hsa040201.13356586
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12931108
43Circadian rhythm_Homo sapiens_hsa047101.09974209
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08780060
45Phototransduction_Homo sapiens_hsa047441.05885711
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04513996
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03322284
48Cardiac muscle contraction_Homo sapiens_hsa042601.01044444
49Gap junction_Homo sapiens_hsa045400.98267284
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97567974
51Parkinsons disease_Homo sapiens_hsa050120.96680301
52Glucagon signaling pathway_Homo sapiens_hsa049220.94260082
53GnRH signaling pathway_Homo sapiens_hsa049120.92134786
54cAMP signaling pathway_Homo sapiens_hsa040240.91051028
55Oocyte meiosis_Homo sapiens_hsa041140.90942455
56ErbB signaling pathway_Homo sapiens_hsa040120.84888542
57Ether lipid metabolism_Homo sapiens_hsa005650.84757940
58Sulfur metabolism_Homo sapiens_hsa009200.83917795
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83734019
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81183213
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80065610
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.77871865
63Rheumatoid arthritis_Homo sapiens_hsa053230.75789916
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75598864
65Vitamin B6 metabolism_Homo sapiens_hsa007500.74730805
66Type II diabetes mellitus_Homo sapiens_hsa049300.72567188
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71188049
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70482162
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69151317
70Estrogen signaling pathway_Homo sapiens_hsa049150.69125214
71Insulin signaling pathway_Homo sapiens_hsa049100.68939919
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67767673
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.67113475
74Arginine and proline metabolism_Homo sapiens_hsa003300.66879352
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.63840302
76Pancreatic secretion_Homo sapiens_hsa049720.63311844
77AMPK signaling pathway_Homo sapiens_hsa041520.61835096
78Ras signaling pathway_Homo sapiens_hsa040140.61625987
79Melanogenesis_Homo sapiens_hsa049160.61323558
80Phagosome_Homo sapiens_hsa041450.60302946
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.59907495
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59762297
83Renal cell carcinoma_Homo sapiens_hsa052110.59412690
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59226908
85Sphingolipid metabolism_Homo sapiens_hsa006000.57549898
86Choline metabolism in cancer_Homo sapiens_hsa052310.56104288
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55255362
88Glioma_Homo sapiens_hsa052140.54811401
89Nitrogen metabolism_Homo sapiens_hsa009100.53911432
90MAPK signaling pathway_Homo sapiens_hsa040100.52707417
91Dilated cardiomyopathy_Homo sapiens_hsa054140.50165776
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49291983
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49184279
94Tight junction_Homo sapiens_hsa045300.48418663
95VEGF signaling pathway_Homo sapiens_hsa043700.46556903
96Arginine biosynthesis_Homo sapiens_hsa002200.46328072
97Dorso-ventral axis formation_Homo sapiens_hsa043200.46156756
98Endocytosis_Homo sapiens_hsa041440.45811408
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44748946
100Thyroid hormone synthesis_Homo sapiens_hsa049180.43548421
101Prion diseases_Homo sapiens_hsa050200.43217810
102mTOR signaling pathway_Homo sapiens_hsa041500.42950592
103Fatty acid metabolism_Homo sapiens_hsa012120.42477099
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42127202
105Propanoate metabolism_Homo sapiens_hsa006400.41769454
106Ovarian steroidogenesis_Homo sapiens_hsa049130.41275365
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40678955
108Alcoholism_Homo sapiens_hsa050340.39953828
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39755532
110Wnt signaling pathway_Homo sapiens_hsa043100.39379550
111beta-Alanine metabolism_Homo sapiens_hsa004100.38083849
112Huntingtons disease_Homo sapiens_hsa050160.37424311
113Inositol phosphate metabolism_Homo sapiens_hsa005620.36274591
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36249258
115Regulation of autophagy_Homo sapiens_hsa041400.35376706
116Bile secretion_Homo sapiens_hsa049760.35259431
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32582435
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32180437
119Rap1 signaling pathway_Homo sapiens_hsa040150.31707611
120Endometrial cancer_Homo sapiens_hsa052130.31150686
121Fatty acid biosynthesis_Homo sapiens_hsa000610.30859308
122Histidine metabolism_Homo sapiens_hsa003400.30486012
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28909370
124Hippo signaling pathway_Homo sapiens_hsa043900.28797207
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.28412819
126Pyruvate metabolism_Homo sapiens_hsa006200.28187807
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26857575

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