CLCN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hippo signaling (GO:0035329)4.25726423
2response to mercury ion (GO:0046689)4.10448669
3chondrocyte proliferation (GO:0035988)4.07090610
4endocardial cushion development (GO:0003197)4.06472314
5paraxial mesoderm development (GO:0048339)4.04930470
6metanephric mesenchyme development (GO:0072075)3.77141634
7negative regulation of fatty acid transport (GO:2000192)3.65122633
8cell adhesion mediated by integrin (GO:0033627)3.63553623
9negative regulation of cholesterol transport (GO:0032375)3.53557567
10negative regulation of sterol transport (GO:0032372)3.53557567
11epoxygenase P450 pathway (GO:0019373)3.45013201
12kidney mesenchyme development (GO:0072074)3.41525587
13regulation of fibrinolysis (GO:0051917)3.41168638
14positive regulation of SMAD protein import into nucleus (GO:0060391)3.34677147
15negative regulation of fibrinolysis (GO:0051918)3.30352233
16wound healing, spreading of epidermal cells (GO:0035313)3.29267620
17regulation of protein activation cascade (GO:2000257)3.28486223
18glomerulus development (GO:0032835)3.25049944
19regulation of transforming growth factor beta2 production (GO:0032909)3.20827733
20regulation of SMAD protein import into nucleus (GO:0060390)3.19236896
21embryonic retina morphogenesis in camera-type eye (GO:0060059)3.19189916
22cytoplasmic mRNA processing body assembly (GO:0033962)3.16357741
23regulation of non-canonical Wnt signaling pathway (GO:2000050)3.15848246
24axon extension involved in axon guidance (GO:0048846)3.13955150
25neuron projection extension involved in neuron projection guidance (GO:1902284)3.13955150
26positive regulation of actin filament depolymerization (GO:0030836)3.11953208
27atrial septum morphogenesis (GO:0060413)3.08280130
28regulation of complement activation (GO:0030449)3.08175979
29ganglion development (GO:0061548)3.05731436
30organ induction (GO:0001759)3.01232521
31dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.01042181
32glyoxylate metabolic process (GO:0046487)3.00670483
33branching involved in salivary gland morphogenesis (GO:0060445)2.99899539
34polarized epithelial cell differentiation (GO:0030859)2.99176433
35mesenchyme development (GO:0060485)2.96908532
36collagen fibril organization (GO:0030199)2.96025136
37regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.94304447
38wound healing, spreading of cells (GO:0044319)2.94255891
39myoblast migration (GO:0051451)2.90819927
40endodermal cell differentiation (GO:0035987)2.90280012
41regulation of cardioblast differentiation (GO:0051890)2.90191538
42positive regulation of catenin import into nucleus (GO:0035413)2.89730018
43peptidyl-glutamic acid carboxylation (GO:0017187)2.89520074
44protein carboxylation (GO:0018214)2.89520074
45gastrulation with mouth forming second (GO:0001702)2.87728947
46midgut development (GO:0007494)2.87484112
47pyrimidine nucleobase catabolic process (GO:0006208)2.85946674
48L-phenylalanine catabolic process (GO:0006559)2.84824309
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.84824309
50body morphogenesis (GO:0010171)2.84304178
51* excretion (GO:0007588)2.83519109
52bone trabecula formation (GO:0060346)2.83319162
53omega-hydroxylase P450 pathway (GO:0097267)2.83041207
54insulin-like growth factor receptor signaling pathway (GO:0048009)2.82678670
55kidney morphogenesis (GO:0060993)2.79891021
56polyol transport (GO:0015791)2.79202099
57drug catabolic process (GO:0042737)2.77889250
58planar cell polarity pathway involved in neural tube closure (GO:0090179)2.76760341
59complement activation, alternative pathway (GO:0006957)2.74962128
60chondrocyte development (GO:0002063)2.74562511
61glomerular visceral epithelial cell development (GO:0072015)2.71470906
62nuclear pore complex assembly (GO:0051292)2.71415513
63basement membrane organization (GO:0071711)2.71370735
64anterior/posterior axis specification, embryo (GO:0008595)2.70864852
65regulation of integrin-mediated signaling pathway (GO:2001044)2.70022704
66regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.69973195
67exogenous drug catabolic process (GO:0042738)2.68910552
68plasma lipoprotein particle assembly (GO:0034377)2.68519055
69plasma membrane repair (GO:0001778)2.66587258
70retina vasculature morphogenesis in camera-type eye (GO:0061299)2.65210320
71regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.65192394
72morphogenesis of an epithelial sheet (GO:0002011)2.64981094
73regulation of bile acid biosynthetic process (GO:0070857)2.64598787
74cholesterol efflux (GO:0033344)2.62034326
75positive regulation of protein depolymerization (GO:1901881)2.60862555
76regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.60394665
77mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.59808247
78notochord development (GO:0030903)2.58910068
79outer ear morphogenesis (GO:0042473)2.58885737
80embryonic cranial skeleton morphogenesis (GO:0048701)2.58509969
81glycine metabolic process (GO:0006544)2.58069055
82craniofacial suture morphogenesis (GO:0097094)2.57221380
83muscle cell migration (GO:0014812)2.56930826
84serine family amino acid catabolic process (GO:0009071)2.56510416
85negative regulation of DNA repair (GO:0045738)2.56483224
86renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.55953141
87dorsal/ventral axis specification (GO:0009950)2.53645696
88cellular response to interferon-alpha (GO:0035457)2.53341824
89muscle cell fate commitment (GO:0042693)2.52795532
90very-low-density lipoprotein particle assembly (GO:0034379)2.52741833
91mesenchymal to epithelial transition (GO:0060231)2.52398959
92mitotic cytokinesis (GO:0000281)2.52104149
93cellular glucuronidation (GO:0052695)2.51749805
94regulation of hippo signaling (GO:0035330)2.51564162
95semaphorin-plexin signaling pathway (GO:0071526)2.51337758
96urate metabolic process (GO:0046415)2.51205067
97nuclear pore organization (GO:0006999)2.50685700
98muscle filament sliding (GO:0030049)2.50435844
99actin-myosin filament sliding (GO:0033275)2.50435844
100embryonic skeletal joint morphogenesis (GO:0060272)2.48480714
101ectodermal placode formation (GO:0060788)2.48398836
102regulation of heart morphogenesis (GO:2000826)2.47851968
103mesodermal cell differentiation (GO:0048333)2.47269288
104bone remodeling (GO:0046849)2.46556819
105erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.46471641
106L-phenylalanine metabolic process (GO:0006558)2.46471641
107cellular response to vitamin D (GO:0071305)2.46264843
108amino-acid betaine metabolic process (GO:0006577)2.45706514
109blood coagulation, intrinsic pathway (GO:0007597)2.44381009
110metanephric epithelium development (GO:0072207)2.44052578
111substrate adhesion-dependent cell spreading (GO:0034446)2.43893634
112genitalia morphogenesis (GO:0035112)2.43738666
113protein-lipid complex assembly (GO:0065005)2.42887116
114myelin assembly (GO:0032288)2.42594755
115phosphate ion homeostasis (GO:0055062)2.42083919
116trivalent inorganic anion homeostasis (GO:0072506)2.42083919
117positive regulation of mesonephros development (GO:0061213)2.41910128
118positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.41746801
119glomerular basement membrane development (GO:0032836)2.41090588
120positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.40958654
121regulation of integrin activation (GO:0033623)2.40476007
122sequestering of extracellular ligand from receptor (GO:0035581)2.40155983
123syncytium formation (GO:0006949)2.39678832
124negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.39647310
125embryonic foregut morphogenesis (GO:0048617)2.39288313
126bile acid biosynthetic process (GO:0006699)2.38317314
127cochlea morphogenesis (GO:0090103)2.37729904
128phospholipid efflux (GO:0033700)2.37569756
129skeletal muscle organ development (GO:0060538)2.37438156
130syncytium formation by plasma membrane fusion (GO:0000768)2.37253035
131negative regulation of striated muscle cell apoptotic process (GO:0010664)2.36683972
132uronic acid metabolic process (GO:0006063)2.35807910
133glucuronate metabolic process (GO:0019585)2.35807910
134positive regulation of male gonad development (GO:2000020)2.35502168
135mesenchymal-epithelial cell signaling (GO:0060638)2.35392790
136eosinophil chemotaxis (GO:0048245)2.34962733
137negative regulation of protein activation cascade (GO:2000258)2.34583565
138G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.34399785
139embryonic forelimb morphogenesis (GO:0035115)2.33932321
140branching involved in prostate gland morphogenesis (GO:0060442)2.33448207
141negative regulation of lipase activity (GO:0060192)2.33417428
142regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.32664444
143nucleobase catabolic process (GO:0046113)2.32098850
144response to lipoprotein particle (GO:0055094)2.32088578
145epithelial cell-cell adhesion (GO:0090136)2.31530668
146bundle of His cell to Purkinje myocyte communication (GO:0086069)2.31368783
147pore complex assembly (GO:0046931)2.30955079
148regulation of organ formation (GO:0003156)2.30758203
149epithelial to mesenchymal transition (GO:0001837)2.30312126
150response to muscle activity (GO:0014850)2.30248110
151negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.29559996
152positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.28896168
153drug transmembrane transport (GO:0006855)2.28752356
154positive regulation of epithelial to mesenchymal transition (GO:0010718)2.28690827
155glucocorticoid receptor signaling pathway (GO:0042921)2.27894236
156cardiovascular system development (GO:0072358)2.27704034
157regulation of cholesterol esterification (GO:0010872)2.27608746
158myoblast fusion (GO:0007520)2.27425752
159plasma lipoprotein particle remodeling (GO:0034369)2.25649867
160protein-lipid complex remodeling (GO:0034368)2.25649867
161macromolecular complex remodeling (GO:0034367)2.25649867
162glomerular epithelial cell development (GO:0072310)2.25606145
163negative regulation of metanephros development (GO:0072217)2.25505727
164actin-mediated cell contraction (GO:0070252)2.25462517
165negative chemotaxis (GO:0050919)2.25320699
166regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.24992231
167reverse cholesterol transport (GO:0043691)2.24927578
168metanephric nephron tubule development (GO:0072234)2.24394939
169metanephric tubule development (GO:0072170)2.24394939
170nephron tubule formation (GO:0072079)2.23564137
171high-density lipoprotein particle remodeling (GO:0034375)2.23405607
172phospholipid homeostasis (GO:0055091)2.23392637
173cytoskeletal anchoring at plasma membrane (GO:0007016)2.22950893
174corticosteroid receptor signaling pathway (GO:0031958)2.22551750
175apoptotic cell clearance (GO:0043277)2.22381500
176cytoskeleton-dependent cytokinesis (GO:0061640)2.22343667
177regulation of mesenchymal cell proliferation (GO:0010464)2.21779574
178diaphragm development (GO:0060539)2.21766274
179regulation of mesonephros development (GO:0061217)2.21508425
180positive regulation of mesenchymal cell proliferation (GO:0002053)2.21315349
181intestinal cholesterol absorption (GO:0030299)2.21274172
182negative regulation of chondrocyte differentiation (GO:0032331)2.21061160
183negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.20757793
184fibrinolysis (GO:0042730)2.20301779
185positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.19879494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.79884327
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.72523029
3* WT1_19549856_ChIP-ChIP_CCG9911_Human3.01592729
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.96029378
5EZH2_22144423_ChIP-Seq_EOC_Human2.89798895
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.80901678
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.48101586
8GBX2_23144817_ChIP-Seq_PC3_Human2.44784685
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.41217236
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40646161
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39354476
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.31403525
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25662672
14* SALL4_18804426_ChIP-ChIP_XEN_Mouse2.22040508
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14419895
16TAF15_26573619_Chip-Seq_HEK293_Human2.14181396
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.10770323
18* CJUN_26792858_Chip-Seq_BT549_Human2.09154061
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.08761212
20TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.07765518
21EP300_21415370_ChIP-Seq_HL-1_Mouse2.03490205
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96994575
23SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.95375649
24CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.93590862
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.92592318
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90236253
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.89879074
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87862401
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.85771368
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.82164635
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80980742
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80159255
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.78391254
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.78391254
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74346558
36BRD4_25478319_ChIP-Seq_HGPS_Human1.74138708
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.69705066
38P300_19829295_ChIP-Seq_ESCs_Human1.67338759
39CLOCK_20551151_ChIP-Seq_293T_Human1.66914387
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65917652
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.65723790
42TP53_18474530_ChIP-ChIP_U2OS_Human1.62980916
43SMAD4_21799915_ChIP-Seq_A2780_Human1.62536504
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.61899659
45SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.61899659
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.61283505
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60834602
48TP53_16413492_ChIP-PET_HCT116_Human1.59183685
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.58922850
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.58111269
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57624174
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56079090
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.55892231
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55611400
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54871936
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54353080
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53935749
58ZNF274_21170338_ChIP-Seq_K562_Hela1.53212823
59ISL1_27105846_Chip-Seq_CPCs_Mouse1.51252131
60IGF1R_20145208_ChIP-Seq_DFB_Human1.49895749
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.46612704
62* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43668059
63CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42818326
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.42320515
65SOX2_20726797_ChIP-Seq_SW620_Human1.41457101
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41143521
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.40897155
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40217836
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39953716
70FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.39329567
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.37001950
72AR_21909140_ChIP-Seq_LNCAP_Human1.36896452
73RNF2_27304074_Chip-Seq_NSC_Mouse1.36262024
74VDR_22108803_ChIP-Seq_LS180_Human1.33476497
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.31868209
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.31589388
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30967195
78FOXA2_19822575_ChIP-Seq_HepG2_Human1.30956143
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30653390
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30653390
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.30541807
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29667492
83AHR_22903824_ChIP-Seq_MCF-7_Human1.29659450
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29599201
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29599201
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29599201
87FUS_26573619_Chip-Seq_HEK293_Human1.28647476
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28332301
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27000779
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26200189
91STAT3_23295773_ChIP-Seq_U87_Human1.26160727
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.25861645
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25114781
94* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24567983
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.24559937
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24003741
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.23817997
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.22630816
99LXR_22158963_ChIP-Seq_LIVER_Mouse1.22405403
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21353447
101ESR2_21235772_ChIP-Seq_MCF-7_Human1.20609391
102FOXM1_23109430_ChIP-Seq_U2OS_Human1.20291889
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.20163197
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19394565
105FOXO3_23340844_ChIP-Seq_DLD1_Human1.19219069
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.17888921
107TP63_23658742_ChIP-Seq_EP156T_Human1.17691155
108EZH2_27304074_Chip-Seq_ESCs_Mouse1.17663499
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17243394
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16213926
111TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15816391
112TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15479914
113BCAT_22108803_ChIP-Seq_LS180_Human1.15088606
114TCF4_23295773_ChIP-Seq_U87_Human1.15036117
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14747339
116PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13858339
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13836271
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.13180164
119RUNX2_22187159_ChIP-Seq_PCA_Human1.13111411
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13021139
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12910423
122UBF1/2_26484160_Chip-Seq_HMECs_Human1.12470522
123JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11720877
124TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11450247
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10346247
126NFE2_27457419_Chip-Seq_LIVER_Mouse1.09728685
127RXR_22108803_ChIP-Seq_LS180_Human1.09430407
128CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09190088
129EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09072995
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07396247
131EED_16625203_ChIP-ChIP_MESCs_Mouse1.07348736
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07193060
133PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06969981
134P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06933952
135POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06827671
136NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06763253
137DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06725623
138SOX2_21211035_ChIP-Seq_LN229_Gbm1.06653075
139TCF4_22108803_ChIP-Seq_LS180_Human1.06354454
140EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05856048
141RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05856048
142EWS_26573619_Chip-Seq_HEK293_Human1.04883641
143TAL1_26923725_Chip-Seq_HPCs_Mouse1.04478317
144KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04373565
145KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04239175
146PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04077955
147RXR_22158963_ChIP-Seq_LIVER_Mouse1.03974022
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03780388
149NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03520968
150SMAD4_21741376_ChIP-Seq_HESCs_Human1.03217483
151YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02995115
152KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02950064
153JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02762839
154RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01916699
155ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01861598
156ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01277383
157STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01034569
158NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00435094
159VDR_24787735_ChIP-Seq_THP-1_Human1.00112688
160TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99303305
161* SOX17_20123909_ChIP-Seq_XEN_Mouse0.98571658
162SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98359654
163NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97397534
164TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96474580
165FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95067320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.99270306
2MP0008438_abnormal_cutaneous_collagen3.72669815
3MP0002139_abnormal_hepatobiliary_system3.50080843
4MP0003122_maternal_imprinting3.46419185
5MP0005623_abnormal_meninges_morphology3.24855546
6MP0004272_abnormal_basement_membrane3.19766166
7MP0003705_abnormal_hypodermis_morpholog3.02875104
8MP0003123_paternal_imprinting2.95748660
9MP0000569_abnormal_digit_pigmentation2.89402737
10MP0010030_abnormal_orbit_morphology2.65049601
11MP0003941_abnormal_skin_development2.56315830
12MP0003121_genomic_imprinting2.49112828
13MP0000537_abnormal_urethra_morphology2.47682904
14MP0002138_abnormal_hepatobiliary_system2.46806404
15MP0005360_urolithiasis2.31530292
16MP0004043_abnormal_pH_regulation2.25069793
17MP0009053_abnormal_anal_canal2.23482472
18MP0000733_abnormal_muscle_development2.22349652
19MP0003950_abnormal_plasma_membrane2.14630219
20MP0003385_abnormal_body_wall2.14357962
21MP0005085_abnormal_gallbladder_physiolo2.13190412
22MP0003252_abnormal_bile_duct2.10153729
23MP0001299_abnormal_eye_distance/2.07637470
24MP0005503_abnormal_tendon_morphology1.93947502
25MP0009384_cardiac_valve_regurgitation1.93451994
26MP0001958_emphysema1.88491261
27MP0003937_abnormal_limbs/digits/tail_de1.85952025
28MP0010352_gastrointestinal_tract_polyps1.85262302
29MP0003942_abnormal_urinary_system1.84752602
30MP0005365_abnormal_bile_salt1.76251111
31MP0005275_abnormal_skin_tensile1.74349299
32MP0000428_abnormal_craniofacial_morphol1.70307505
33MP0005076_abnormal_cell_differentiation1.67807273
34MP0009250_abnormal_appendicular_skeleto1.62123544
35MP0005257_abnormal_intraocular_pressure1.60207267
36MP0003279_aneurysm1.53609079
37MP0000534_abnormal_ureter_morphology1.53601585
38MP0003566_abnormal_cell_adhesion1.53501735
39MP0003136_yellow_coat_color1.53498457
40MP0003091_abnormal_cell_migration1.50955132
41MP0003755_abnormal_palate_morphology1.50782438
42MP0010368_abnormal_lymphatic_system1.47524239
43MP0005367_renal/urinary_system_phenotyp1.46517655
44MP0000516_abnormal_urinary_system1.46517655
45MP0003115_abnormal_respiratory_system1.44118868
46MP0001666_abnormal_nutrient_absorption1.43138675
47MP0005508_abnormal_skeleton_morphology1.41852334
48MP0003315_abnormal_perineum_morphology1.39226348
49MP0003890_abnormal_embryonic-extraembry1.38848982
50MP0004197_abnormal_fetal_growth/weight/1.38578315
51* MP0000432_abnormal_head_morphology1.34989088
52* MP0001756_abnormal_urination1.33572367
53MP0004019_abnormal_vitamin_homeostasis1.33548887
54MP0003567_abnormal_fetal_cardiomyocyte1.32584668
55MP0002233_abnormal_nose_morphology1.32528441
56MP0005248_abnormal_Harderian_gland1.30324972
57MP0002932_abnormal_joint_morphology1.29910493
58MP0002877_abnormal_melanocyte_morpholog1.28588614
59MP0003868_abnormal_feces_composition1.27545196
60MP0004145_abnormal_muscle_electrophysio1.23687443
61MP0002896_abnormal_bone_mineralization1.23169181
62MP0005377_hearing/vestibular/ear_phenot1.21268681
63MP0003878_abnormal_ear_physiology1.21268681
64MP0002697_abnormal_eye_size1.20111504
65MP0004233_abnormal_muscle_weight1.19103330
66MP0005408_hypopigmentation1.17811486
67MP0009697_abnormal_copulation1.13376148
68MP0002084_abnormal_developmental_patter1.12672364
69MP0000767_abnormal_smooth_muscle1.12070439
70* MP0005332_abnormal_amino_acid1.11763877
71MP0003119_abnormal_digestive_system1.10138512
72* MP0003935_abnormal_craniofacial_develop1.06794524
73MP0002177_abnormal_outer_ear1.06431687
74MP0001661_extended_life_span1.06277285
75MP0000749_muscle_degeneration1.05935199
76MP0002116_abnormal_craniofacial_bone1.05544590
77MP0002115_abnormal_skeleton_extremities1.05422882
78MP0000778_abnormal_nervous_system1.05309147
79MP0001915_intracranial_hemorrhage1.03009538
80MP0002111_abnormal_tail_morphology1.02598329
81MP0004270_analgesia1.01419012
82MP0000049_abnormal_middle_ear1.00701571
83MP0002109_abnormal_limb_morphology1.00583264
84* MP0002114_abnormal_axial_skeleton1.00440147
85MP0004264_abnormal_extraembryonic_tissu0.99700371
86MP0001293_anophthalmia0.97324052
87MP0002113_abnormal_skeleton_development0.95763257
88MP0009703_decreased_birth_body0.94542669
89MP0002085_abnormal_embryonic_tissue0.94153405
90MP0002282_abnormal_trachea_morphology0.93876166
91MP0002086_abnormal_extraembryonic_tissu0.93714836
92MP0000751_myopathy0.93297778
93MP0000163_abnormal_cartilage_morphology0.92177905
94MP0010234_abnormal_vibrissa_follicle0.91661721
95MP0006054_spinal_hemorrhage0.90077135
96MP0002925_abnormal_cardiovascular_devel0.89341992
97MP0002928_abnormal_bile_duct0.88916450
98MP0001324_abnormal_eye_pigmentation0.88886063
99MP0005220_abnormal_exocrine_pancreas0.88830907
100MP0004858_abnormal_nervous_system0.88677768
101MP0010678_abnormal_skin_adnexa0.88571870
102MP0010329_abnormal_lipoprotein_level0.87152403
103MP0005369_muscle_phenotype0.86586970
104MP0008932_abnormal_embryonic_tissue0.86347798
105MP0002168_other_aberrant_phenotype0.85784084
106MP0005451_abnormal_body_composition0.85527831
107MP0008789_abnormal_olfactory_epithelium0.85371754
108MP0005023_abnormal_wound_healing0.85051344
109MP0001175_abnormal_lung_morphology0.84701817
110MP0000372_irregular_coat_pigmentation0.84647005
111MP0005187_abnormal_penis_morphology0.84340397
112MP0009672_abnormal_birth_weight0.84200730
113MP0002938_white_spotting0.83710201
114MP0003943_abnormal_hepatobiliary_system0.83393053
115MP0005380_embryogenesis_phenotype0.82413765
116MP0001672_abnormal_embryogenesis/_devel0.82413765
117MP0002088_abnormal_embryonic_growth/wei0.82202259
118MP0001697_abnormal_embryo_size0.81306746
119MP0000566_synostosis0.81210012
120MP0002106_abnormal_muscle_physiology0.80751234
121MP0002092_abnormal_eye_morphology0.80545795
122MP0000762_abnormal_tongue_morphology0.80399293
123MP0005409_darkened_coat_color0.79923046
124MP0004084_abnormal_cardiac_muscle0.79808223
125MP0005197_abnormal_uvea_morphology0.79386892
126MP0003984_embryonic_growth_retardation0.79383556
127MP0002108_abnormal_muscle_morphology0.78895619
128MP0001346_abnormal_lacrimal_gland0.78448271
129MP0000538_abnormal_urinary_bladder0.78382855
130MP0001348_abnormal_lacrimal_gland0.77973570
131MP0002269_muscular_atrophy0.77557892
132MP0000747_muscle_weakness0.77512439
133MP0003938_abnormal_ear_development0.77121176
134MP0002102_abnormal_ear_morphology0.76624260
135MP0001286_abnormal_eye_development0.76314235
136MP0006292_abnormal_olfactory_placode0.76173744
137MP0004133_heterotaxia0.75160291
138MP0004134_abnormal_chest_morphology0.73102627
139MP0002249_abnormal_larynx_morphology0.72911195
140MP0005171_absent_coat_pigmentation0.72233702
141MP0002089_abnormal_postnatal_growth/wei0.72109172
142MP0000631_abnormal_neuroendocrine_gland0.71838087
143MP0003861_abnormal_nervous_system0.71544100
144MP0005391_vision/eye_phenotype0.68731560
145MP0000383_abnormal_hair_follicle0.66805987
146MP0004087_abnormal_muscle_fiber0.66782849
147MP0002751_abnormal_autonomic_nervous0.64532283

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)4.96080930
2Distal arthrogryposis (HP:0005684)4.74454057
3Metabolic alkalosis (HP:0200114)3.95241546
4Premature rupture of membranes (HP:0001788)3.95198477
5Calcaneovalgus deformity (HP:0001848)3.63193703
6Round ear (HP:0100830)3.60547403
7Hypomagnesemia (HP:0002917)3.54233273
8Ulnar deviation of the wrist (HP:0003049)3.53180892
9Hyperactive renin-angiotensin system (HP:0000841)3.51437084
10Hypokalemic alkalosis (HP:0001949)3.42460602
11Asymmetry of the thorax (HP:0001555)3.24509386
12Deformed tarsal bones (HP:0008119)3.11086121
13Aplasia of the musculature (HP:0100854)3.03907518
14Abnormality of chloride homeostasis (HP:0011422)2.99065032
15Deep venous thrombosis (HP:0002625)2.96683173
16Shallow orbits (HP:0000586)2.94799220
17Protrusio acetabuli (HP:0003179)2.92541330
18Hypokalemia (HP:0002900)2.82140109
19Malignant hyperthermia (HP:0002047)2.74827702
20Abnormality of magnesium homeostasis (HP:0004921)2.72897886
21Polyuria (HP:0000103)2.72382728
22Absent phalangeal crease (HP:0006109)2.67696064
23Short nail (HP:0001799)2.67308590
24Hyperaldosteronism (HP:0000859)2.67069994
25Abnormal urine output (HP:0012590)2.65606854
26Subacute progressive viral hepatitis (HP:0006572)2.65365526
27Spinal cord lesions (HP:0100561)2.60390534
28Syringomyelia (HP:0003396)2.60390534
29Long clavicles (HP:0000890)2.60032819
30Potter facies (HP:0002009)2.59223743
31Facial shape deformation (HP:0011334)2.59223743
32Osteolytic defects of the hand bones (HP:0009699)2.57623198
33Osteolytic defects of the phalanges of the hand (HP:0009771)2.57623198
34* Proximal tubulopathy (HP:0000114)2.56401721
35Short 4th metacarpal (HP:0010044)2.51357782
36Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.51357782
37Hypobetalipoproteinemia (HP:0003563)2.43834672
38Prolonged partial thromboplastin time (HP:0003645)2.42199920
39Mesomelia (HP:0003027)2.37135090
40Abnormal finger flexion creases (HP:0006143)2.35106347
41Gout (HP:0001997)2.34981596
42Abnormality of renal excretion (HP:0011036)2.33367004
43Fragile skin (HP:0001030)2.32693470
44Abnormality of the distal phalanges of the toes (HP:0010182)2.28700808
45Scapular winging (HP:0003691)2.28367398
46Papillary thyroid carcinoma (HP:0002895)2.23520209
47Cerebral aneurysm (HP:0004944)2.23293724
48Cutaneous syndactyly (HP:0012725)2.22742072
49* Hypercalciuria (HP:0002150)2.21678892
50Cervical subluxation (HP:0003308)2.21460821
51Abnormality of potassium homeostasis (HP:0011042)2.21028607
52Fused cervical vertebrae (HP:0002949)2.20981184
53Enlarged kidneys (HP:0000105)2.19770157
54Hypoplastic ischia (HP:0003175)2.18563943
55Aortic dissection (HP:0002647)2.17903333
56Complement deficiency (HP:0004431)2.16834881
57Wormian bones (HP:0002645)2.16328471
58Hip contracture (HP:0003273)2.14766536
59Abnormality of the nasal septum (HP:0000419)2.14027701
60* Osteomalacia (HP:0002749)2.13657592
61Renal salt wasting (HP:0000127)2.13399845
62Ankle contracture (HP:0006466)2.12985352
63Knee flexion contracture (HP:0006380)2.12795962
64Cystic hygroma (HP:0000476)2.11698077
65Abnormality of the ischium (HP:0003174)2.11658922
66Abnormality of the distal phalanx of the thumb (HP:0009617)2.09621007
67Wrist flexion contracture (HP:0001239)2.09136394
68Soft skin (HP:0000977)2.05628988
69Vitreoretinal degeneration (HP:0000655)2.02423293
70Cutaneous finger syndactyly (HP:0010554)2.01765947
71Muscle fiber splitting (HP:0003555)2.01296461
72Hepatoblastoma (HP:0002884)2.01035041
73Pterygium (HP:0001059)2.01031315
74Abnormality of dentin (HP:0010299)2.00697764
75Thin ribs (HP:0000883)1.97649641
76Bifid tongue (HP:0010297)1.97635423
77Disinhibition (HP:0000734)1.97475613
78Arterial tortuosity (HP:0005116)1.96860173
79Dilatation of the ascending aorta (HP:0005111)1.95963432
80Breech presentation (HP:0001623)1.95627091
81Popliteal pterygium (HP:0009756)1.93334049
82Bell-shaped thorax (HP:0001591)1.92975546
83Amniotic constriction ring (HP:0009775)1.92836553
84Abnormality of placental membranes (HP:0011409)1.92836553
85Abnormality of monocarboxylic acid metabolism (HP:0010996)1.91806830
86Metatarsus adductus (HP:0001840)1.91704657
87Generalized aminoaciduria (HP:0002909)1.91302597
88Polydipsia (HP:0001959)1.90945692
89Abnormal drinking behavior (HP:0030082)1.90945692
90Coronal craniosynostosis (HP:0004440)1.89030073
91Myelomeningocele (HP:0002475)1.88563999
92Tetany (HP:0001281)1.88477779
93Fair hair (HP:0002286)1.88343917
94Camptodactyly of toe (HP:0001836)1.87855135
95Vascular tortuosity (HP:0004948)1.86748514
96Broad thumb (HP:0011304)1.86729862
97Atrophic scars (HP:0001075)1.86432706
98Increased number of teeth (HP:0011069)1.86126091
99Fetal akinesia sequence (HP:0001989)1.85903556
100Mildly elevated creatine phosphokinase (HP:0008180)1.84766946
101Bicornuate uterus (HP:0000813)1.84418885
102Diaphragmatic weakness (HP:0009113)1.84089762
103Mitral valve prolapse (HP:0001634)1.83933677
104Abnormality of aromatic amino acid family metabolism (HP:0004338)1.83849885
105Natal tooth (HP:0000695)1.83705215
106Tarsal synostosis (HP:0008368)1.83585402
107Abnormal ossification of hand bones (HP:0005921)1.81697403
108Microglossia (HP:0000171)1.81512210
109Anophthalmia (HP:0000528)1.81163839
110Abnormality of the calf musculature (HP:0001430)1.81097808
111Arthropathy (HP:0003040)1.81003545
112Aortic aneurysm (HP:0004942)1.80425694
113Hypolipoproteinemia (HP:0010981)1.80273603
114Abnormality of renin-angiotensin system (HP:0000847)1.79772857
115Abnormality of carpal bone ossification (HP:0006257)1.79432574
116Abnormal auditory evoked potentials (HP:0006958)1.79162968
117Conjugated hyperbilirubinemia (HP:0002908)1.78653621
118Type 1 muscle fiber predominance (HP:0003803)1.77838606
119Absent frontal sinuses (HP:0002688)1.77325723
120Macroorchidism (HP:0000053)1.77149477
121Hypoplastic heart (HP:0001961)1.76488194
122Neoplasm of the heart (HP:0100544)1.76382216
123Abnormal vertebral ossification (HP:0100569)1.74842942
124Chin dimple (HP:0010751)1.74010183
125Buphthalmos (HP:0000557)1.73875142
126Synostosis involving bones of the feet (HP:0009140)1.73418220
127Synostosis involving bones of the lower limbs (HP:0009138)1.73418220
128Wide anterior fontanel (HP:0000260)1.73329625
129Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.72783168
130Abnormality of the calcaneus (HP:0008364)1.72514565
131Neonatal respiratory distress (HP:0002643)1.72330825
132Renal hypoplasia (HP:0000089)1.72169076
133Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72060522
134Renovascular hypertension (HP:0100817)1.71333059
135Limited hip movement (HP:0008800)1.70297870
136Akinesia (HP:0002304)1.70141063
137Upper limb amyotrophy (HP:0009129)1.70110147
138Distal upper limb amyotrophy (HP:0007149)1.70110147
139Abnormality of the pubic bones (HP:0003172)1.69912354
140Fibular aplasia (HP:0002990)1.69720188
141Spinal rigidity (HP:0003306)1.69602547
142Abnormality of the 4th metacarpal (HP:0010012)1.69598799
143Blue sclerae (HP:0000592)1.69558824
144Intrahepatic cholestasis (HP:0001406)1.69410564
145Morphological abnormality of the middle ear (HP:0008609)1.69330492
146Type 2 muscle fiber atrophy (HP:0003554)1.67627300
147Abnormality of the middle phalanges of the toes (HP:0010183)1.67591095
148Alkalosis (HP:0001948)1.67253021
149Abnormality of the common coagulation pathway (HP:0010990)1.66890881
150Neonatal short-limb short stature (HP:0008921)1.66409355
151Deviation of the hallux (HP:0010051)1.64996129
152Insidious onset (HP:0003587)1.64754033
153Termporal pattern (HP:0011008)1.64754033
154Abnormal tarsal ossification (HP:0008369)1.64244097
155Elbow flexion contracture (HP:0002987)1.64199222
156Abnormal pancreas size (HP:0012094)1.63244529
157Joint contractures involving the joints of the feet (HP:0100492)1.62248128
158Flexion contracture of toe (HP:0005830)1.62248128
159Short humerus (HP:0005792)1.61733506
160Rectal prolapse (HP:0002035)1.60402426
161Volvulus (HP:0002580)1.60282654
162Bladder diverticulum (HP:0000015)1.60236411
163Vertebral clefting (HP:0008428)1.59087961
164Absent eyebrow (HP:0002223)1.59003425
165Spinal cord compression (HP:0002176)1.58826797
166* Tubular atrophy (HP:0000092)1.56778188
167Infantile muscular hypotonia (HP:0008947)1.56637592
168Metaphyseal dysplasia (HP:0100255)1.56090727
169Broad long bones (HP:0005622)1.55110107
170Decreased muscle mass (HP:0003199)1.54825802
171Midline defect of the nose (HP:0004122)1.54517479
172Broad face (HP:0000283)1.54252101
173Broad toe (HP:0001837)1.54064928
174Preaxial foot polydactyly (HP:0001841)1.53918232
175Exostoses (HP:0100777)1.53896995
176Hallux valgus (HP:0001822)1.53565061
177Flat acetabular roof (HP:0003180)1.53559819
178Deviation of the thumb (HP:0009603)1.53527397
179Abnormal delivery (HP:0001787)1.52142502
180Nephroblastoma (Wilms tumor) (HP:0002667)1.50837479
181Hypoalphalipoproteinemia (HP:0003233)1.47837082
182Generalized muscle weakness (HP:0003324)1.47716967
183* Glycosuria (HP:0003076)1.47354405
184* Abnormality of urine glucose concentration (HP:0011016)1.47354405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.25391508
2PNCK2.66613019
3LATS22.59983542
4STK32.54694766
5CDK122.54511045
6DDR22.40047796
7STK38L2.33550268
8CASK2.28677784
9ERBB32.07023917
10WNK31.92998309
11TTN1.91992602
12WNK41.89701259
13EPHB21.87863907
14EPHA21.87209702
15LIMK11.80432768
16OBSCN1.73121351
17MOS1.71385515
18BCR1.70524902
19FRK1.70290281
20BMPR1B1.69878369
21ACVR1B1.61631676
22MAP3K41.60239277
23PDGFRA1.59996001
24MET1.58946294
25ERBB41.56842219
26SCYL21.53393562
27TNIK1.50390849
28STK391.48333098
29TRPM71.45531040
30ZAK1.42598154
31TIE11.41152217
32EPHB11.40465432
33PTK21.40077853
34PBK1.37933183
35NTRK31.33894348
36NLK1.33476238
37FGFR41.32170878
38FER1.31476525
39PAK31.30861103
40PTK61.28379121
41FGFR11.27618132
42WNK11.27603222
43BMX1.26714033
44STK101.26074236
45NUAK11.22912465
46BRSK21.17989752
47PAK21.14471131
48PLK21.14102640
49MST41.08892060
50PIK3CG1.07272139
51CDK61.05562936
52MKNK11.03566647
53MTOR1.00251186
54PAK40.98588700
55OXSR10.97130497
56DMPK0.96789446
57TESK10.91847011
58PLK40.91569433
59EEF2K0.90612261
60NEK90.89523269
61MKNK20.89523105
62ROCK10.88911846
63MAP3K100.87894306
64STK240.84604479
65TRIB30.83344306
66PDGFRB0.83249056
67ICK0.82999728
68FGFR20.82239781
69PKN20.81873554
70AKT30.78724804
71MAP3K140.76823780
72CSNK1G10.75818191
73MELK0.75190061
74MAP2K40.72967200
75MUSK0.69289934
76MARK10.67583709
77WEE10.67097291
78SGK2230.65941427
79SGK4940.65941427
80CHUK0.65863184
81MAP2K10.64871466
82PLK30.64474634
83PRKAA10.63750683
84ROCK20.63497999
85LRRK20.63308527
86FGR0.62637180
87CAMK1D0.62522530
88PRKAA20.62367255
89RET0.60201939
90STK160.59443786
91ILK0.58800208
92PIK3CA0.58434811
93KSR10.57527197
94BRD40.57185847
95TGFBR10.57023038
96DYRK1B0.56522112
97TTK0.56499501
98TRIM280.56374307
99EPHA30.55387867
100GSK3A0.55276571
101PRKCE0.54834448
102RPS6KB10.54506762
103CDC70.53831966
104SGK30.53070885
105ERBB20.53023303
106INSR0.52798326
107MST1R0.52533746
108CAMK1G0.51174652
109MAP3K80.51003643
110CSNK1A1L0.49961584
111CSNK1E0.49961176
112MAP3K70.47963875
113ADRBK20.47640582
114NEK20.47555249
115FGFR30.47527224
116PRKCG0.46865509
117CDC42BPA0.46659413
118EGFR0.46468723
119ATM0.46015677
120SGK20.46013832
121CSNK1G20.46000207
122PLK10.45525431
123MAP3K20.45431190
124STK40.44836501
125NTRK20.43082419
126CDK140.42679916
127YES10.39194309
128AKT20.39182439
129TYRO30.38860109
130PAK10.38767835
131RPS6KB20.38638720
132PINK10.38446346
133PRKACB0.38376986
134DYRK20.38168344
135MAPKAPK20.37811443
136SGK10.36608283
137PRKG10.36485655
138MAP3K60.34667865
139STK110.34387231
140EPHA40.34128722
141PDK20.32398884
142CDK70.31514250
143CDK90.30891789
144MAPK130.30644091
145MINK10.30134693

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.20094141
2Complement and coagulation cascades_Homo sapiens_hsa046102.86105107
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.83666196
4Adherens junction_Homo sapiens_hsa045202.38164096
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36548274
6Retinol metabolism_Homo sapiens_hsa008302.33889249
7Hippo signaling pathway_Homo sapiens_hsa043902.26997909
8ECM-receptor interaction_Homo sapiens_hsa045122.25214683
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23867741
10Proteoglycans in cancer_Homo sapiens_hsa052052.03647626
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.03292123
12TGF-beta signaling pathway_Homo sapiens_hsa043501.98763658
13Focal adhesion_Homo sapiens_hsa045101.93443849
14Fatty acid degradation_Homo sapiens_hsa000711.90529151
15Hedgehog signaling pathway_Homo sapiens_hsa043401.87977836
16Tight junction_Homo sapiens_hsa045301.87372771
17Basal cell carcinoma_Homo sapiens_hsa052171.85617697
18MicroRNAs in cancer_Homo sapiens_hsa052061.84944639
19Caffeine metabolism_Homo sapiens_hsa002321.81271061
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.77336765
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.76777459
22Butanoate metabolism_Homo sapiens_hsa006501.73826677
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.72172905
24Small cell lung cancer_Homo sapiens_hsa052221.68973260
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67863937
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.63939792
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63026422
28Viral myocarditis_Homo sapiens_hsa054161.62303325
29Propanoate metabolism_Homo sapiens_hsa006401.62291322
30Steroid biosynthesis_Homo sapiens_hsa001001.61409003
31Dilated cardiomyopathy_Homo sapiens_hsa054141.58920611
32Mineral absorption_Homo sapiens_hsa049781.57357018
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.53010462
34Phagosome_Homo sapiens_hsa041451.48950810
35Starch and sucrose metabolism_Homo sapiens_hsa005001.48493639
36Histidine metabolism_Homo sapiens_hsa003401.47694340
37Tryptophan metabolism_Homo sapiens_hsa003801.47433469
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.46577323
39Chemical carcinogenesis_Homo sapiens_hsa052041.45026915
40Amoebiasis_Homo sapiens_hsa051461.44906454
41Bile secretion_Homo sapiens_hsa049761.44417610
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41283697
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40644742
44Arginine biosynthesis_Homo sapiens_hsa002201.40069347
45Salmonella infection_Homo sapiens_hsa051321.39786037
46Lysine degradation_Homo sapiens_hsa003101.38628998
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36623280
48Prostate cancer_Homo sapiens_hsa052151.35821951
49Lysosome_Homo sapiens_hsa041421.35420555
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33296747
51Protein digestion and absorption_Homo sapiens_hsa049741.32896329
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.31865035
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.28224300
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26284512
55Axon guidance_Homo sapiens_hsa043601.23682269
56Regulation of actin cytoskeleton_Homo sapiens_hsa048101.23491192
57Melanoma_Homo sapiens_hsa052181.23372251
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23250205
59Chronic myeloid leukemia_Homo sapiens_hsa052201.21506130
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21048165
61Malaria_Homo sapiens_hsa051441.19915266
62Rheumatoid arthritis_Homo sapiens_hsa053231.19316715
63Pancreatic cancer_Homo sapiens_hsa052121.16506399
64Cyanoamino acid metabolism_Homo sapiens_hsa004601.14255212
65Linoleic acid metabolism_Homo sapiens_hsa005911.13957994
66Bladder cancer_Homo sapiens_hsa052191.13859259
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13523909
68Endometrial cancer_Homo sapiens_hsa052131.13352109
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11703513
70Fat digestion and absorption_Homo sapiens_hsa049751.10769179
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10318807
72Drug metabolism - other enzymes_Homo sapiens_hsa009831.10278468
73Renin-angiotensin system_Homo sapiens_hsa046141.09527013
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08651690
75Toxoplasmosis_Homo sapiens_hsa051451.06651640
76Dorso-ventral axis formation_Homo sapiens_hsa043201.06360955
77Colorectal cancer_Homo sapiens_hsa052101.05457524
78Tyrosine metabolism_Homo sapiens_hsa003501.04314102
79Phenylalanine metabolism_Homo sapiens_hsa003601.03221712
80Renal cell carcinoma_Homo sapiens_hsa052111.02489659
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01919379
82Pathways in cancer_Homo sapiens_hsa052001.01627649
83Leishmaniasis_Homo sapiens_hsa051401.01323611
84Vibrio cholerae infection_Homo sapiens_hsa051101.00642219
85PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00598367
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00525327
87Legionellosis_Homo sapiens_hsa051340.98890859
88Graft-versus-host disease_Homo sapiens_hsa053320.97494009
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97458004
90beta-Alanine metabolism_Homo sapiens_hsa004100.96592647
91Shigellosis_Homo sapiens_hsa051310.94690228
92PPAR signaling pathway_Homo sapiens_hsa033200.93810389
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93704891
94Peroxisome_Homo sapiens_hsa041460.92241051
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92234049
96Cell cycle_Homo sapiens_hsa041100.91374556
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90465365
98Collecting duct acid secretion_Homo sapiens_hsa049660.90312566
99Wnt signaling pathway_Homo sapiens_hsa043100.90302168
100Arginine and proline metabolism_Homo sapiens_hsa003300.90180246
101p53 signaling pathway_Homo sapiens_hsa041150.87368454
102ABC transporters_Homo sapiens_hsa020100.87084916
103Tuberculosis_Homo sapiens_hsa051520.85857022
104TNF signaling pathway_Homo sapiens_hsa046680.84695443
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.84404587
106Viral carcinogenesis_Homo sapiens_hsa052030.84225411
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80127812
108FoxO signaling pathway_Homo sapiens_hsa040680.79176106
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78946654
110Apoptosis_Homo sapiens_hsa042100.78619341
111Pyruvate metabolism_Homo sapiens_hsa006200.77508586
112ErbB signaling pathway_Homo sapiens_hsa040120.76210224
113Glioma_Homo sapiens_hsa052140.75975695
114Melanogenesis_Homo sapiens_hsa049160.75371378
115Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74047671
116Sphingolipid metabolism_Homo sapiens_hsa006000.73458075
117HTLV-I infection_Homo sapiens_hsa051660.71498665
118Pertussis_Homo sapiens_hsa051330.71300528
119Endocytosis_Homo sapiens_hsa041440.70943032
120Rap1 signaling pathway_Homo sapiens_hsa040150.70723895
121Fatty acid metabolism_Homo sapiens_hsa012120.69434599
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68458087
123Ovarian steroidogenesis_Homo sapiens_hsa049130.67621554
124Selenocompound metabolism_Homo sapiens_hsa004500.65576328
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65145955
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.65022828
127mTOR signaling pathway_Homo sapiens_hsa041500.64069722
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63367722
129Hepatitis B_Homo sapiens_hsa051610.62309434
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62164706
131Vitamin digestion and absorption_Homo sapiens_hsa049770.62021794
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61254978
133One carbon pool by folate_Homo sapiens_hsa006700.60061940
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.59839512
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59568124
136Sulfur metabolism_Homo sapiens_hsa009200.58677789
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58625263
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57873592
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56246852
140Prion diseases_Homo sapiens_hsa050200.56154861
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55031518
142Hepatitis C_Homo sapiens_hsa051600.54971241
143Ether lipid metabolism_Homo sapiens_hsa005650.54139152
144Autoimmune thyroid disease_Homo sapiens_hsa053200.54098727
145Prolactin signaling pathway_Homo sapiens_hsa049170.53833018
146Allograft rejection_Homo sapiens_hsa053300.53531226
147Thyroid cancer_Homo sapiens_hsa052160.53507021
1482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52545236
149Thyroid hormone synthesis_Homo sapiens_hsa049180.52204265
150HIF-1 signaling pathway_Homo sapiens_hsa040660.51944739
151Notch signaling pathway_Homo sapiens_hsa043300.51856329
152Carbon metabolism_Homo sapiens_hsa012000.49369359
153Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49193451
154Basal transcription factors_Homo sapiens_hsa030220.44435705
155Glucagon signaling pathway_Homo sapiens_hsa049220.43841615
156Arachidonic acid metabolism_Homo sapiens_hsa005900.39299543
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.39081235
158AMPK signaling pathway_Homo sapiens_hsa041520.37320081
159alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37157998
160Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36431860
161Non-homologous end-joining_Homo sapiens_hsa034500.36318740
162Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31006438
163Metabolic pathways_Homo sapiens_hsa011000.30545552
164Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30128676
165Choline metabolism in cancer_Homo sapiens_hsa052310.29247485
166Phototransduction_Homo sapiens_hsa047440.29229979

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