CLCN7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact6.45882528
2modulation by symbiont of host immune response (GO:0052553)6.45882528
3positive regulation by symbiont of host defense response (GO:0052509)6.45882528
4modulation by symbiont of host defense response (GO:0052031)6.45882528
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.45882528
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.45882528
7negative regulation of erythrocyte differentiation (GO:0045647)5.19280130
8macrophage activation involved in immune response (GO:0002281)4.84518692
9mannose metabolic process (GO:0006013)4.79738907
10response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.41406309
11response to host immune response (GO:0052572)4.41406309
12regulation of interferon-beta biosynthetic process (GO:0045357)4.18430401
13microglial cell activation (GO:0001774)4.09849595
14response to peptidoglycan (GO:0032494)4.05677735
15positive regulation of cellular amide metabolic process (GO:0034250)4.05305048
16positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.90373421
17response to host (GO:0075136)3.87030204
18response to host defenses (GO:0052200)3.87030204
19response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.87030204
20neutrophil activation involved in immune response (GO:0002283)3.86906991
21positive regulation of interferon-alpha production (GO:0032727)3.84113228
22I-kappaB phosphorylation (GO:0007252)3.64606761
23regulation of interferon-alpha production (GO:0032647)3.62694963
24detection of molecule of bacterial origin (GO:0032490)3.53748024
25superoxide anion generation (GO:0042554)3.47150677
26positive regulation of heat generation (GO:0031652)3.46655828
27respiratory burst (GO:0045730)3.45592832
28macrophage activation (GO:0042116)3.42196332
29positive regulation of antigen processing and presentation (GO:0002579)3.41274890
30barbed-end actin filament capping (GO:0051016)3.41234219
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.40910470
32protein localization to endosome (GO:0036010)3.37558469
33glycosphingolipid catabolic process (GO:0046479)3.31192906
34hydrogen peroxide biosynthetic process (GO:0050665)3.30838286
35positive regulation of chemokine biosynthetic process (GO:0045080)3.29940639
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.24784884
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.24784884
38positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.20924477
39cellular response to thyroid hormone stimulus (GO:0097067)3.18962114
40lipopolysaccharide-mediated signaling pathway (GO:0031663)3.12955565
41regulation of leukocyte degranulation (GO:0043300)3.12745231
42regulation of dendritic cell antigen processing and presentation (GO:0002604)3.10634804
43response to muramyl dipeptide (GO:0032495)3.10596886
44melanin biosynthetic process (GO:0042438)3.10539603
45pinocytosis (GO:0006907)3.08355208
46regulation of early endosome to late endosome transport (GO:2000641)3.05988429
47regulation of cholesterol storage (GO:0010885)3.01810583
48positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.00947269
49amino sugar catabolic process (GO:0046348)2.97708653
50regulation of mononuclear cell migration (GO:0071675)2.97263320
51positive regulation of toll-like receptor signaling pathway (GO:0034123)2.96431916
52melanin metabolic process (GO:0006582)2.95454865
53granulocyte activation (GO:0036230)2.94214682
54myeloid cell activation involved in immune response (GO:0002275)2.93188059
55regulation of myeloid leukocyte mediated immunity (GO:0002886)2.92140153
56glycolipid catabolic process (GO:0019377)2.91590669
57regulation of fever generation (GO:0031620)2.91248946
58negative regulation of cell killing (GO:0031342)2.90666257
59negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.90666257
60response to thyroid hormone (GO:0097066)2.89965596
61NIK/NF-kappaB signaling (GO:0038061)2.89199928
62antigen processing and presentation of endogenous antigen (GO:0019883)2.86995150
63regulation of antigen processing and presentation (GO:0002577)2.86354880
64basic amino acid transport (GO:0015802)2.83989095
65low-density lipoprotein particle clearance (GO:0034383)2.83240396
66positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.82297069
67response to laminar fluid shear stress (GO:0034616)2.82093570
68regulation of interleukin-8 biosynthetic process (GO:0045414)2.81909924
69reactive oxygen species biosynthetic process (GO:1903409)2.81532464
70response to type I interferon (GO:0034340)2.80632237
71epithelial cell differentiation involved in prostate gland development (GO:0060742)2.80441504
72positive regulation of gamma-delta T cell activation (GO:0046645)2.80348370
73natural killer cell mediated immunity (GO:0002228)2.79285685
74natural killer cell mediated cytotoxicity (GO:0042267)2.79285685
75cellular response to type I interferon (GO:0071357)2.78776896
76type I interferon signaling pathway (GO:0060337)2.78776896
77neutrophil activation (GO:0042119)2.78676496
78detection of bacterium (GO:0016045)2.77604247
79immunoglobulin mediated immune response (GO:0016064)2.76372462
80positive regulation of interferon-beta production (GO:0032728)2.73797556
81negative regulation of lipid storage (GO:0010888)2.73050776
82germinal center formation (GO:0002467)2.72826079
83eosinophil chemotaxis (GO:0048245)2.72275487
84semaphorin-plexin signaling pathway (GO:0071526)2.71475996
85regulation of heat generation (GO:0031650)2.70542541
86positive thymic T cell selection (GO:0045059)2.70073981
87negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.68113007
88regulation of gamma-delta T cell activation (GO:0046643)2.67513737
89stress fiber assembly (GO:0043149)2.66737677
90negative regulation of interleukin-12 production (GO:0032695)2.64627157
91response to interferon-alpha (GO:0035455)2.62159626
92positive regulation of Cdc42 GTPase activity (GO:0043089)2.61629437
93regulation of ARF GTPase activity (GO:0032312)2.61355485
94negative regulation of granulocyte differentiation (GO:0030853)2.60649711
95regulation of mast cell degranulation (GO:0043304)2.60084353
96intracellular pH reduction (GO:0051452)2.58666404
97monocyte chemotaxis (GO:0002548)2.56220660
98neutrophil mediated immunity (GO:0002446)2.55800618
99phagosome maturation (GO:0090382)2.55378743
100detection of external biotic stimulus (GO:0098581)2.55154882
101modulation by virus of host process (GO:0019054)2.54891917
102adhesion of symbiont to host (GO:0044406)2.54495326
103positive regulation of receptor recycling (GO:0001921)2.54388347
104L-amino acid import (GO:0043092)2.53280413
105oligosaccharide catabolic process (GO:0009313)2.52527451
106regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.52362986
107regulation of membrane protein ectodomain proteolysis (GO:0051043)2.52032840
108positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.51860508
109regulation of T-helper 2 cell differentiation (GO:0045628)2.51652103
110regulation of regulated secretory pathway (GO:1903305)2.51073804
111detection of biotic stimulus (GO:0009595)2.49765512
112apoptotic cell clearance (GO:0043277)2.49443480
113lipoprotein transport (GO:0042953)2.49353733
114plasma lipoprotein particle clearance (GO:0034381)2.48965405
115regulation of extracellular matrix disassembly (GO:0010715)2.48959643
116cell-cell junction maintenance (GO:0045217)2.47696126
117negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.47490850
118regulation of chemokine biosynthetic process (GO:0045073)2.45513899
119detection of other organism (GO:0098543)2.45093018
120activation of MAPKKK activity (GO:0000185)2.44836751
121N-acetylneuraminate metabolic process (GO:0006054)2.44081868
122regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.43267426
123modification by symbiont of host morphology or physiology (GO:0044003)2.42027580
124basement membrane organization (GO:0071711)2.42013449
125ceramide catabolic process (GO:0046514)2.41119681
126apoptotic process involved in morphogenesis (GO:0060561)2.40986673
127regulation of mast cell activation involved in immune response (GO:0033006)2.40837589
128positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.40820294
129activation of JUN kinase activity (GO:0007257)2.40738127
130positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.39961404
131regulation of type I interferon-mediated signaling pathway (GO:0060338)2.39647812
132virion attachment to host cell (GO:0019062)2.37788417
133adhesion of symbiont to host cell (GO:0044650)2.37788417
134thymic T cell selection (GO:0045061)2.37606181
135eosinophil migration (GO:0072677)2.37287108
136cellular extravasation (GO:0045123)2.36218745
137positive regulation of mast cell degranulation (GO:0043306)2.34922504
138positive regulation of mast cell activation involved in immune response (GO:0033008)2.34922504
139negative regulation of mast cell activation (GO:0033004)2.34801128
140regulation of podosome assembly (GO:0071801)2.34664093
141negative regulation of cell size (GO:0045792)2.34509691
142regulation of gamma-delta T cell differentiation (GO:0045586)2.34414641
143hyaluronan catabolic process (GO:0030214)2.33905944
144regulation of monocyte differentiation (GO:0045655)2.33107610
145positive regulation of cholesterol efflux (GO:0010875)2.32252589
146positive regulation of protein dephosphorylation (GO:0035307)2.31760126
147interferon-gamma-mediated signaling pathway (GO:0060333)2.31645300
148modulation by symbiont of host cellular process (GO:0044068)2.31166086
149regulation of B cell receptor signaling pathway (GO:0050855)2.30662174
150superoxide metabolic process (GO:0006801)2.29755433
151regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.29204581
152positive regulation of mast cell activation (GO:0033005)2.28880051
153cell adhesion mediated by integrin (GO:0033627)2.28800155
154positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.27778565
155T-helper 1 type immune response (GO:0042088)2.27470053
156myeloid dendritic cell differentiation (GO:0043011)2.26533737
157regulation of superoxide anion generation (GO:0032928)2.26334110
158negative regulation of toll-like receptor signaling pathway (GO:0034122)2.25437118
159macroautophagy (GO:0016236)2.25258756
160peptide catabolic process (GO:0043171)2.23967649
161lymphocyte chemotaxis (GO:0048247)2.23818588
162positive regulation of phagocytosis (GO:0050766)2.23745932
163cytokine secretion (GO:0050663)2.23340088
164positive regulation of lipid storage (GO:0010884)2.23105611
165antigen processing and presentation via MHC class Ib (GO:0002475)2.22490915
166protein retention in ER lumen (GO:0006621)2.22247274
167positive regulation of extracellular matrix organization (GO:1903055)2.22086775
168pentose-phosphate shunt (GO:0006098)2.21765221
169regulation of lipid kinase activity (GO:0043550)2.21320499

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.68604488
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.54604336
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.85064996
4Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.36610700
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.35025404
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.25126332
7* VDR_21846776_ChIP-Seq_THP-1_Human3.22434325
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10576281
9LXR_22292898_ChIP-Seq_THP-1_Human2.91877046
10MYC_22102868_ChIP-Seq_BL_Human2.59242669
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.52723871
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.42101889
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41147016
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.36046529
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31697341
16KDM2B_26808549_Chip-Seq_DND41_Human2.24996663
17TCF7_22412390_ChIP-Seq_EML_Mouse2.21115457
18* VDR_24763502_ChIP-Seq_THP-1_Human2.19453302
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00353057
20RACK7_27058665_Chip-Seq_MCF-7_Human2.00251045
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.98124646
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97894026
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90917447
24KDM2B_26808549_Chip-Seq_K562_Human1.85818673
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.84697937
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.84260745
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82997754
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69146125
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.68444093
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67163144
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66450737
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63504275
33MAF_26560356_Chip-Seq_TH1_Human1.62384451
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62331451
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61473614
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.60361614
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.59838098
38* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55329395
39* VDR_24787735_ChIP-Seq_THP-1_Human1.53685813
40P68_20966046_ChIP-Seq_HELA_Human1.51670530
41CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51212938
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50965779
43KDM2B_26808549_Chip-Seq_JURKAT_Human1.50692790
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50546350
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50129624
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49816674
47UTX_26944678_Chip-Seq_JUKART_Human1.48695531
48* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48028793
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47604184
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.44040097
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43333777
52* MAF_26560356_Chip-Seq_TH2_Human1.42813441
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42717636
54ZNF263_19887448_ChIP-Seq_K562_Human1.42607006
55FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41534163
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41287912
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40126230
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39792624
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39484054
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38655583
61* SMC4_20622854_ChIP-Seq_HELA_Human1.37366394
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.36984152
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.36556203
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35593204
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35478985
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33005958
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.31547124
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.30525361
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.30128889
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29686080
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29681412
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29392136
73NCOR1_26117541_ChIP-Seq_K562_Human1.29305917
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29203894
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29185437
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27850351
77BCOR_27268052_Chip-Seq_Bcells_Human1.26898370
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26200974
79GBX2_23144817_ChIP-Seq_PC3_Human1.25959110
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25803655
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25417882
82PPARA_22158963_ChIP-Seq_LIVER_Mouse1.25280618
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24762435
84SPI1_23127762_ChIP-Seq_K562_Human1.23967861
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23420965
86CLOCK_20551151_ChIP-Seq_293T_Human1.20560647
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20385898
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20385898
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18972098
90CREB1_26743006_Chip-Seq_LNCaP_Human1.18185694
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17153092
92BCL6_27268052_Chip-Seq_Bcells_Human1.16435500
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16032724
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13050900
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12994662
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12721599
97PU_27001747_Chip-Seq_BMDM_Mouse1.12604703
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11628091
99TRIM28_21343339_ChIP-Seq_HEK293_Human1.11130912
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10828956
101* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10687707
102PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10550728
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09531326
104SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08241713
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07546155
106CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07068591
107SPI1_23547873_ChIP-Seq_NB4_Human1.05167909
108SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04324974
109* RUNX1_27514584_Chip-Seq_MCF-7_Human1.03990351
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03847512
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03784735
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01674563
113TP53_22127205_ChIP-Seq_IMR90_Human1.01155740
114AR_21572438_ChIP-Seq_LNCaP_Human1.00536278
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99100476
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97057867
117ATF3_27146783_Chip-Seq_COLON_Human0.96811011
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95806019
119RXR_22108803_ChIP-Seq_LS180_Human0.95324879
120SMAD_19615063_ChIP-ChIP_OVARY_Human0.95299602
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95197003
122SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95183659
123ESR2_21235772_ChIP-Seq_MCF-7_Human0.94585314
124PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94503657
125GATA1_22025678_ChIP-Seq_K562_Human0.94218624
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93782221
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.93586683
128SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92785445
129TP53_18474530_ChIP-ChIP_U2OS_Human0.92639999
130STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92254971
131SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91637779
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91633646
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91560491
134TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90222499
135SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89536358
136DROSHA_22980978_ChIP-Seq_HELA_Human0.89420152
137TP53_16413492_ChIP-PET_HCT116_Human0.89226649
138MTF2_20144788_ChIP-Seq_MESCs_Mouse0.87145428
139CJUN_26792858_Chip-Seq_BT549_Human0.86932193
140AHR_22903824_ChIP-Seq_MCF-7_Human0.86294671
141SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85622071
142CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84156406
143ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84060596
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.83716714
145RUNX_20019798_ChIP-Seq_JUKART_Human0.83630466
146IGF1R_20145208_ChIP-Seq_DFB_Human0.82968342
147CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82249429
148BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81430656
149SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.80586128
150ARNT_22903824_ChIP-Seq_MCF-7_Human0.79691353
151JARID2_20064375_ChIP-Seq_MESCs_Mouse0.79385237
152AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78739564
153EZH2_18974828_ChIP-Seq_MESCs_Mouse0.77879389
154RNF2_18974828_ChIP-Seq_MESCs_Mouse0.77879389
155PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77357769
156CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.77176087
157PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77027656
158FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74016189
159SMAD3_21741376_ChIP-Seq_HESCs_Human0.72757262
160PU1_27457419_Chip-Seq_LIVER_Mouse0.72755117
161KDM2B_26808549_Chip-Seq_SUP-B15_Human0.72114624
162SUZ12_27294783_Chip-Seq_ESCs_Mouse0.71523026
163CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.71041742
164CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70864922
165CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70777914
166PPAR_26484153_Chip-Seq_NCI-H1993_Human0.69857359
167SCL_19346495_ChIP-Seq_HPC-7_Human0.69635180
168FOXA2_19822575_ChIP-Seq_HepG2_Human0.68934408
169JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68460744
170PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.68449130
171GATA1_19941826_ChIP-Seq_K562_Human0.68415564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.76961105
2* MP0005058_abnormal_lysosome_morphology3.53682422
3MP0003303_peritoneal_inflammation3.34629462
4MP0003436_decreased_susceptibility_to3.30694562
5MP0004510_myositis3.14067177
6MP0006082_CNS_inflammation3.13217378
7MP0001835_abnormal_antigen_presentation3.01409445
8* MP0003172_abnormal_lysosome_physiology2.75364392
9* MP0002419_abnormal_innate_immunity2.73729374
10MP0009840_abnormal_foam_cell2.61818610
11MP0009785_altered_susceptibility_to2.46002596
12MP0003724_increased_susceptibility_to2.42791181
13MP0001790_abnormal_immune_system2.42020088
14MP0005387_immune_system_phenotype2.42020088
15MP0002877_abnormal_melanocyte_morpholog2.37597160
16MP0003191_abnormal_cellular_cholesterol2.30696977
17MP0005000_abnormal_immune_tolerance2.25891313
18MP0005025_abnormal_response_to2.17941680
19MP0003690_abnormal_glial_cell2.16394574
20MP0005171_absent_coat_pigmentation2.14995365
21MP0000604_amyloidosis2.13684073
22MP0001849_ear_inflammation2.11744550
23MP0005257_abnormal_intraocular_pressure2.07796857
24MP0002148_abnormal_hypersensitivity_rea2.01509614
25MP0005464_abnormal_platelet_physiology1.98277224
26MP0001533_abnormal_skeleton_physiology1.95082231
27MP0003183_abnormal_peptide_metabolism1.94150172
28MP0005409_darkened_coat_color1.91471317
29MP0004858_abnormal_nervous_system1.89719023
30MP0004947_skin_inflammation1.87323445
31* MP0002452_abnormal_antigen_presenting1.84882277
32MP0005076_abnormal_cell_differentiation1.78651066
33MP0003075_altered_response_to1.76055999
34MP0003195_calcinosis1.75582993
35MP0009764_decreased_sensitivity_to1.74713845
36MP0003329_amyloid_beta_deposits1.73235510
37MP0002723_abnormal_immune_serum1.70184788
38MP0009278_abnormal_bone_marrow1.67964191
39MP0005174_abnormal_tail_pigmentation1.67474929
40MP0001800_abnormal_humoral_immune1.65550741
41MP0000015_abnormal_ear_pigmentation1.60015638
42* MP0002998_abnormal_bone_remodeling1.57947582
43MP0003279_aneurysm1.57329768
44MP0008469_abnormal_protein_level1.53617544
45MP0005360_urolithiasis1.52887804
46MP0005083_abnormal_biliary_tract1.48781937
47MP0000685_abnormal_immune_system1.45945085
48* MP0008260_abnormal_autophagy1.45710977
49MP0002254_reproductive_system_inflammat1.45246604
50MP0005397_hematopoietic_system_phenotyp1.44582855
51MP0001545_abnormal_hematopoietic_system1.44582855
52MP0001958_emphysema1.44304685
53MP0002139_abnormal_hepatobiliary_system1.42688349
54MP0003448_altered_tumor_morphology1.36720996
55MP0008438_abnormal_cutaneous_collagen1.36523489
56* MP0001819_abnormal_immune_cell1.32808405
57MP0005671_abnormal_response_to1.32737712
58MP0001845_abnormal_inflammatory_respons1.32668117
59MP0009333_abnormal_splenocyte_physiolog1.30217074
60MP0000343_altered_response_to1.30119771
61MP0003300_gastrointestinal_ulcer1.28669130
62* MP0002420_abnormal_adaptive_immunity1.28083812
63MP0005451_abnormal_body_composition1.24895528
64MP0005164_abnormal_response_to1.19368722
65MP0005310_abnormal_salivary_gland1.18561775
66MP0005166_decreased_susceptibility_to1.17350330
67MP0000371_diluted_coat_color1.14330324
68MP0002090_abnormal_vision1.10400415
69MP0002405_respiratory_system_inflammati1.09651027
70MP0005167_abnormal_blood-brain_barrier1.08845399
71MP0005075_abnormal_melanosome_morpholog1.08350314
72MP0004782_abnormal_surfactant_physiolog1.05562446
73MP0010386_abnormal_urinary_bladder1.05443151
74MP0003763_abnormal_thymus_physiology1.04426049
75MP0003091_abnormal_cell_migration1.00785989
76MP0000920_abnormal_myelination0.99978517
77MP0005390_skeleton_phenotype0.99389826
78MP0004185_abnormal_adipocyte_glucose0.99275231
79MP0009763_increased_sensitivity_to0.98526582
80MP0002075_abnormal_coat/hair_pigmentati0.97784126
81MP0002277_abnormal_respiratory_mucosa0.97395674
82MP0002089_abnormal_postnatal_growth/wei0.96548004
83MP0002398_abnormal_bone_marrow0.96418744
84MP0003045_fibrosis0.95957051
85MP0005023_abnormal_wound_healing0.95886787
86MP0002933_joint_inflammation0.95479766
87MP0004808_abnormal_hematopoietic_stem0.95011668
88MP0005408_hypopigmentation0.93907533
89MP0001501_abnormal_sleep_pattern0.93110268
90MP0005197_abnormal_uvea_morphology0.91938557
91MP0002332_abnormal_exercise_endurance0.91844653
92MP0004019_abnormal_vitamin_homeostasis0.91246563
93MP0005670_abnormal_white_adipose0.90863671
94MP0001853_heart_inflammation0.89627438
95MP0000678_abnormal_parathyroid_gland0.87898873
96* MP0002429_abnormal_blood_cell0.86777611
97MP0005666_abnormal_adipose_tissue0.84830493
98MP0001851_eye_inflammation0.84689836
99MP0001348_abnormal_lacrimal_gland0.84181393
100MP0004742_abnormal_vestibular_system0.83819367
101MP0010329_abnormal_lipoprotein_level0.83765489
102MP0004381_abnormal_hair_follicle0.83484830
103* MP0003634_abnormal_glial_cell0.83459687
104MP0003136_yellow_coat_color0.82478147
105MP0000609_abnormal_liver_physiology0.80779236
106* MP0003795_abnormal_bone_structure0.79223384
107MP0003705_abnormal_hypodermis_morpholog0.78452961
108MP0002118_abnormal_lipid_homeostasis0.77247706
109MP0003656_abnormal_erythrocyte_physiolo0.77218088
110MP0002396_abnormal_hematopoietic_system0.77152009
111MP0002722_abnormal_immune_system0.77132255
112MP0004130_abnormal_muscle_cell0.76616857
113MP0010155_abnormal_intestine_physiology0.75418796
114MP0000249_abnormal_blood_vessel0.75187229
115* MP0000716_abnormal_immune_system0.74998660
116MP0003566_abnormal_cell_adhesion0.74904893
117MP0001186_pigmentation_phenotype0.74745042
118MP0001873_stomach_inflammation0.74398542
119MP0000681_abnormal_thyroid_gland0.73263314
120MP0005365_abnormal_bile_salt0.71533133
121MP0000689_abnormal_spleen_morphology0.71202635
122MP0005085_abnormal_gallbladder_physiolo0.70509273
123MP0005375_adipose_tissue_phenotype0.70332862
124MP0010234_abnormal_vibrissa_follicle0.70165589
125MP0000767_abnormal_smooth_muscle0.69953530
126MP0002136_abnormal_kidney_physiology0.69273505
127MP0002971_abnormal_brown_adipose0.68879794
128MP0003453_abnormal_keratinocyte_physiol0.68838422
129MP0001324_abnormal_eye_pigmentation0.68389085
130MP0000858_altered_metastatic_potential0.68146795
131MP0009046_muscle_twitch0.66469128
132MP0003828_pulmonary_edema0.66275350
133MP0003252_abnormal_bile_duct0.65479681
134MP0005319_abnormal_enzyme/_coenzyme0.64694565

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.81639778
2Eczematoid dermatitis (HP:0000976)5.58518520
3Recurrent gram-negative bacterial infections (HP:0005420)5.50596611
4Increased cerebral lipofuscin (HP:0011813)5.21810627
5Recurrent bacterial skin infections (HP:0005406)5.21444417
6Vacuolated lymphocytes (HP:0001922)4.56083586
7Abnormality of macrophages (HP:0004311)4.47456338
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.33061570
9Systemic lupus erythematosus (HP:0002725)4.10264602
10Gingivitis (HP:0000230)3.93482611
11Abnormality of glycolipid metabolism (HP:0010969)3.91293379
12Abnormality of liposaccharide metabolism (HP:0010968)3.91293379
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.91293379
14Axonal loss (HP:0003447)3.66806962
15Mediastinal lymphadenopathy (HP:0100721)3.57879768
16Stomatitis (HP:0010280)3.49963638
17Dysostosis multiplex (HP:0000943)3.46837852
18Glomerulonephritis (HP:0000099)3.43028091
19Joint hemorrhage (HP:0005261)3.41135970
20Recurrent skin infections (HP:0001581)3.36248937
21Loss of speech (HP:0002371)3.32022965
22Myocardial infarction (HP:0001658)3.30086100
23Abnormality of polysaccharide metabolism (HP:0011012)3.27064632
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.27064632
25Abnormality of mucopolysaccharide metabolism (HP:0011020)3.27064632
26Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.15844749
27Prostate neoplasm (HP:0100787)3.13162675
28Mucopolysacchariduria (HP:0008155)3.12264948
29Urinary glycosaminoglycan excretion (HP:0003541)3.12264948
30Cerebral aneurysm (HP:0004944)3.05539606
31Tetraparesis (HP:0002273)2.93704251
32Autoimmune thrombocytopenia (HP:0001973)2.92616922
33Amyloidosis (HP:0011034)2.88492084
34Chronic obstructive pulmonary disease (HP:0006510)2.85780967
35Obstructive lung disease (HP:0006536)2.85780967
36Orchitis (HP:0100796)2.82445792
37Thick nail (HP:0001805)2.79710578
38Nephritis (HP:0000123)2.78917068
39Retrobulbar optic neuritis (HP:0100654)2.66527863
40Optic neuritis (HP:0100653)2.66527863
41Nuclear cataract (HP:0100018)2.63847852
42Complement deficiency (HP:0004431)2.60891255
43Ocular albinism (HP:0001107)2.59795208
44Protrusio acetabuli (HP:0003179)2.59653003
45Elevated erythrocyte sedimentation rate (HP:0003565)2.59312602
46Recurrent fungal infections (HP:0002841)2.58769669
47Pathologic fracture (HP:0002756)2.52652106
48Disinhibition (HP:0000734)2.50569594
49Gingival bleeding (HP:0000225)2.49221346
50Peripheral demyelination (HP:0011096)2.47783587
51J-shaped sella turcica (HP:0002680)2.46250548
52Prolonged partial thromboplastin time (HP:0003645)2.44066600
53Supranuclear gaze palsy (HP:0000605)2.43324144
54Obstructive sleep apnea (HP:0002870)2.41817442
55Hyperacusis (HP:0010780)2.41244080
56Basal ganglia calcification (HP:0002135)2.40120834
57* Bone pain (HP:0002653)2.40070419
58Cellulitis (HP:0100658)2.39268429
59Thoracic kyphosis (HP:0002942)2.37880620
60Myositis (HP:0100614)2.37818796
61Vasculitis (HP:0002633)2.36656520
62Cervical subluxation (HP:0003308)2.33956249
63Periodontitis (HP:0000704)2.33355367
64Broad face (HP:0000283)2.31251303
65Thin bony cortex (HP:0002753)2.30989700
66Abnormality of complement system (HP:0005339)2.29465737
67Neurofibrillary tangles (HP:0002185)2.28839707
68Purpura (HP:0000979)2.28420809
69Chronic otitis media (HP:0000389)2.27059295
70Abnormality of the thoracic spine (HP:0100711)2.26829707
71Chronic mucocutaneous candidiasis (HP:0002728)2.24702207
72Recurrent cutaneous fungal infections (HP:0011370)2.24702207
73Upper limb amyotrophy (HP:0009129)2.17181492
74Distal upper limb amyotrophy (HP:0007149)2.17181492
75Urticaria (HP:0001025)2.15969990
76Achilles tendon contracture (HP:0001771)2.15657008
77Abnormality of proline metabolism (HP:0010907)2.13192707
78Hydroxyprolinuria (HP:0003080)2.13192707
79Prolonged neonatal jaundice (HP:0006579)2.12770719
80Frequent falls (HP:0002359)2.12223015
81Increased IgE level (HP:0003212)2.10456515
82Pulmonary infiltrates (HP:0002113)2.10029856
83Distal lower limb amyotrophy (HP:0008944)2.08081328
84Asymmetric septal hypertrophy (HP:0001670)2.07164160
85Colitis (HP:0002583)2.07148394
86Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.06475966
87Slow saccadic eye movements (HP:0000514)2.05446028
88Mitral stenosis (HP:0001718)2.05150442
89Distal lower limb muscle weakness (HP:0009053)2.03599280
90Progressive visual loss (HP:0000529)2.02879615
91Premature rupture of membranes (HP:0001788)2.02609909
92Peripheral hypomyelination (HP:0007182)1.99721844
93Upper motor neuron abnormality (HP:0002127)1.98714675
94Iris hypopigmentation (HP:0007730)1.98484428
95Polygenic inheritance (HP:0010982)1.95396456
96Joint stiffness (HP:0001387)1.95025898
97Apathy (HP:0000741)1.94993574
98Global brain atrophy (HP:0002283)1.94663735
99Xanthomatosis (HP:0000991)1.94623194
100Neuronal loss in central nervous system (HP:0002529)1.94552693
101Recurrent viral infections (HP:0004429)1.93736319
102Diminished motivation (HP:0000745)1.93406213
103Hematochezia (HP:0002573)1.93038876
104Increased connective tissue (HP:0009025)1.92732283
105Abnormality of the Achilles tendon (HP:0005109)1.91916373
106Increased serum ferritin (HP:0003281)1.91714608
107Spontaneous hematomas (HP:0007420)1.91489562
108Hemorrhage of the eye (HP:0011885)1.88416204
109Hypercholesterolemia (HP:0003124)1.88191877
110Recurrent pneumonia (HP:0006532)1.88058107
111Submucous cleft hard palate (HP:0000176)1.86806832
112Interstitial pulmonary disease (HP:0006530)1.86677637
113Elevated alkaline phosphatase (HP:0003155)1.86145740
114Segmental peripheral demyelination/remyelination (HP:0003481)1.86108380
115Pulmonary artery stenosis (HP:0004415)1.85975760
116Increased CSF protein (HP:0002922)1.84932643
117Centrally nucleated skeletal muscle fibers (HP:0003687)1.84580544
118Deep venous thrombosis (HP:0002625)1.84025769
119Stridor (HP:0010307)1.83287399
120Aneurysm (HP:0002617)1.82820827
121Emphysema (HP:0002097)1.82185055
122Gastrointestinal inflammation (HP:0004386)1.79882544
123Vertebral compression fractures (HP:0002953)1.78440519
124Hyperlipoproteinemia (HP:0010980)1.78115302
125Spondylolisthesis (HP:0003302)1.77373061
126Polycythemia (HP:0001901)1.77186401
127Abnormality of the vasculature of the conjunctiva (HP:0008054)1.77179994
128Retinal atrophy (HP:0001105)1.76528206
129Abnormality of glutamine family amino acid metabolism (HP:0010902)1.76232733
130Gastrointestinal stroma tumor (HP:0100723)1.76077181
131Upper limb muscle weakness (HP:0003484)1.73526787
132Pustule (HP:0200039)1.72971019
133Abnormality of the periventricular white matter (HP:0002518)1.72616605
134Menorrhagia (HP:0000132)1.72191450
135Progressive neurologic deterioration (HP:0002344)1.72082652
136Disproportionate tall stature (HP:0001519)1.71493905
137* Hypophosphatemia (HP:0002148)1.71187763
138Restrictive lung disease (HP:0002091)1.71165020
139Cerebral inclusion bodies (HP:0100314)1.70232189
140* Osteomyelitis (HP:0002754)1.69780256
141Esophageal varix (HP:0002040)1.69321113
142Vascular calcification (HP:0004934)1.69265937
143Ulnar bowing (HP:0003031)1.68847863
144Deformed sella turcica (HP:0002681)1.68805583
145Inflammation of the large intestine (HP:0002037)1.68582200
146Hypertriglyceridemia (HP:0002155)1.67882306
147Increased IgM level (HP:0003496)1.67411055
148Dementia (HP:0000726)1.65182236
149Malnutrition (HP:0004395)1.65121801
150Hand muscle atrophy (HP:0009130)1.64594521
151Petechiae (HP:0000967)1.64021038
152Mitral regurgitation (HP:0001653)1.63881936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.86186706
2TRIB33.91615592
3RIPK43.63643760
4MAP3K143.26142861
5IRAK32.94405367
6ERN12.84053150
7TYK22.79635646
8TBK12.63094187
9IKBKE2.53609509
10MAP3K132.44933657
11IRAK42.37674877
12PBK2.29545202
13JAK12.22204952
14ICK2.18966052
15SMG12.16193954
16EPHB12.15374544
17KIT2.14791738
18MAP2K32.09072566
19TAOK32.02922214
20SIK21.97414750
21MAP3K111.81216285
22FGR1.76591383
23NME21.74766025
24FGFR41.74213427
25EEF2K1.69956697
26TGFBR21.66827037
27FES1.53676219
28CSK1.51429452
29TAOK21.50307364
30MAP3K31.48526761
31JAK31.46074693
32EPHA31.43809077
33CAMK1D1.43484198
34IKBKB1.39923817
35CAMK1G1.32205831
36MAP4K11.31207869
37MARK21.31131687
38RIPK11.30939195
39DAPK21.30182611
40HCK1.29973227
41INSRR1.26467578
42PKN21.23820122
43TTN1.22501080
44PRKD21.21862137
45PKN11.20710550
46TXK1.19926897
47IRAK11.19277394
48IRAK21.18578576
49PDGFRA1.17204565
50SIK11.16305843
51TAOK11.14105195
52RPS6KA21.09717291
53MST1R1.04892968
54GRK71.03067525
55BMX0.97798991
56JAK20.97570667
57PTK60.96427350
58TYRO30.96394086
59MAP3K60.94806806
60KSR20.93127149
61EIF2AK20.89541266
62RPS6KL10.88819109
63RPS6KC10.88819109
64CSF1R0.88612053
65GRK10.86517977
66SYK0.86204607
67TESK10.85876963
68TESK20.85873095
69LYN0.84486947
70PAK40.84290482
71MTOR0.83337406
72MAP3K100.83261988
73PRKD30.81468241
74CHUK0.80302821
75LCK0.79468142
76HIPK20.73623076
77BTK0.72733173
78SIK30.71691610
79DDR20.71579586
80CAMKK10.70275693
81FGFR30.69891436
82GRK60.68551320
83CLK10.68187711
84ARAF0.68109301
85RPS6KA60.67171557
86ABL20.65883550
87CASK0.65728345
88ERBB40.65634807
89MATK0.65240184
90FYN0.63586185
91ABL10.63280259
92MAPK70.61958635
93YES10.61614505
94MAP3K70.60938617
95MARK30.60723624
96PIK3CG0.59098945
97EGFR0.58202745
98PIM20.58001507
99PDPK10.56505234
100MAP2K60.54830532
101SGK10.54592599
102MAPK110.54409630
103RET0.54102934
104MOS0.53975477
105CDK60.50689332
106PDGFRB0.50486800
107LRRK20.49876598
108PRKCQ0.48550283
109PRKAA20.47971469
110EPHA20.47841902
111PRKCD0.47622108
112CDK40.46026414
113NTRK10.45767687
114ZAP700.45084205
115DYRK1B0.45075704
116PTK20.44869218
117MAP2K20.44544070
118MAP3K80.44511675
119PAK60.44038455
120TNK20.43919526
121PRPF4B0.42540632
122PDK10.42315933
123INSR0.40862365
124SRC0.38833567
125BMPR20.36815795
126PRKCE0.35943645
127DMPK0.35929675
128MAP3K10.35275953
129CDK120.34204845
130CDC42BPA0.33806175
131ADRBK20.32773973
132FER0.32546894
133MAPK120.32543228
134TRPM70.31981677
135NEK90.31568049
136PTK2B0.29579934
137PRKCH0.28849578
138WNK10.28573394
139PRKD10.27095135
140EPHB20.26081598
141DAPK30.25953348
142MAP3K50.25645422
143IGF1R0.24844334
144NUAK10.24213996
145SGK30.22840167
146ERBB20.22591144

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.75839590
2Lysosome_Homo sapiens_hsa041422.47052914
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.39679305
4Leishmaniasis_Homo sapiens_hsa051402.38843817
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.26982307
6Osteoclast differentiation_Homo sapiens_hsa043802.12025978
7Malaria_Homo sapiens_hsa051441.94089716
8Complement and coagulation cascades_Homo sapiens_hsa046101.92815678
9Acute myeloid leukemia_Homo sapiens_hsa052211.91581639
10Caffeine metabolism_Homo sapiens_hsa002321.91531789
11Tuberculosis_Homo sapiens_hsa051521.87950588
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.82461496
13Other glycan degradation_Homo sapiens_hsa005111.73204679
14Pertussis_Homo sapiens_hsa051331.72100172
15Phagosome_Homo sapiens_hsa041451.70267146
16Rheumatoid arthritis_Homo sapiens_hsa053231.70261395
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61042791
18Graft-versus-host disease_Homo sapiens_hsa053321.56082086
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49790005
20VEGF signaling pathway_Homo sapiens_hsa043701.47289047
21Notch signaling pathway_Homo sapiens_hsa043301.46978464
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46233747
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45081428
24Measles_Homo sapiens_hsa051621.41214284
25TNF signaling pathway_Homo sapiens_hsa046681.37811814
26Influenza A_Homo sapiens_hsa051641.33289242
27Bladder cancer_Homo sapiens_hsa052191.32192572
28African trypanosomiasis_Homo sapiens_hsa051431.26028766
29B cell receptor signaling pathway_Homo sapiens_hsa046621.23105047
30Non-small cell lung cancer_Homo sapiens_hsa052231.21536939
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19314564
32Type II diabetes mellitus_Homo sapiens_hsa049301.18904048
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.18790930
34ABC transporters_Homo sapiens_hsa020101.18024295
35Asthma_Homo sapiens_hsa053101.16861436
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.15812990
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13401557
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10872500
39Legionellosis_Homo sapiens_hsa051341.10179668
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08595596
41Chemokine signaling pathway_Homo sapiens_hsa040621.06734031
42Arginine biosynthesis_Homo sapiens_hsa002201.06360021
43Collecting duct acid secretion_Homo sapiens_hsa049661.04170046
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02600000
45Toxoplasmosis_Homo sapiens_hsa051451.01921432
46Salmonella infection_Homo sapiens_hsa051321.01036563
47Hepatitis C_Homo sapiens_hsa051601.00094686
48Galactose metabolism_Homo sapiens_hsa000520.99827011
49Allograft rejection_Homo sapiens_hsa053300.99375408
50GnRH signaling pathway_Homo sapiens_hsa049120.96446181
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.95499558
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94030010
53mTOR signaling pathway_Homo sapiens_hsa041500.93585712
54Renal cell carcinoma_Homo sapiens_hsa052110.92739596
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92235130
56Amoebiasis_Homo sapiens_hsa051460.92124196
57Fructose and mannose metabolism_Homo sapiens_hsa000510.91104119
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88156379
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87425943
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86737824
61Endometrial cancer_Homo sapiens_hsa052130.83476919
62Nitrogen metabolism_Homo sapiens_hsa009100.82215984
63Sphingolipid metabolism_Homo sapiens_hsa006000.81824934
64Viral myocarditis_Homo sapiens_hsa054160.81538230
65Endocytosis_Homo sapiens_hsa041440.81107618
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79603269
67PPAR signaling pathway_Homo sapiens_hsa033200.78214870
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78151897
69Glioma_Homo sapiens_hsa052140.78080629
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.76649846
71Pentose phosphate pathway_Homo sapiens_hsa000300.75877731
72Apoptosis_Homo sapiens_hsa042100.75574525
73ErbB signaling pathway_Homo sapiens_hsa040120.75523821
74Estrogen signaling pathway_Homo sapiens_hsa049150.74840175
75Hematopoietic cell lineage_Homo sapiens_hsa046400.74760229
76Insulin signaling pathway_Homo sapiens_hsa049100.72922986
77Histidine metabolism_Homo sapiens_hsa003400.72408117
78Steroid biosynthesis_Homo sapiens_hsa001000.71597830
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.70645673
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70021759
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69519355
82Prion diseases_Homo sapiens_hsa050200.69380837
83Choline metabolism in cancer_Homo sapiens_hsa052310.68773723
84Platelet activation_Homo sapiens_hsa046110.67830173
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67733199
86Mineral absorption_Homo sapiens_hsa049780.65443399
87Vibrio cholerae infection_Homo sapiens_hsa051100.64876154
88Focal adhesion_Homo sapiens_hsa045100.63995183
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63682949
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.63333487
91HIF-1 signaling pathway_Homo sapiens_hsa040660.63169684
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62468353
93HTLV-I infection_Homo sapiens_hsa051660.62382949
94Small cell lung cancer_Homo sapiens_hsa052220.62166146
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60653520
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60586614
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.59248700
98Tryptophan metabolism_Homo sapiens_hsa003800.58410473
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58288413
100Proteoglycans in cancer_Homo sapiens_hsa052050.57548506
101Peroxisome_Homo sapiens_hsa041460.56406345
102Dorso-ventral axis formation_Homo sapiens_hsa043200.53087741
103Thyroid cancer_Homo sapiens_hsa052160.52830756
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.52138465
105Herpes simplex infection_Homo sapiens_hsa051680.51282460
106Bile secretion_Homo sapiens_hsa049760.50158239
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49251630
108Viral carcinogenesis_Homo sapiens_hsa052030.49195669
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.48248514
110beta-Alanine metabolism_Homo sapiens_hsa004100.47921662
111Shigellosis_Homo sapiens_hsa051310.46685053
112Hepatitis B_Homo sapiens_hsa051610.46557386
113Lysine degradation_Homo sapiens_hsa003100.46497520
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46336849
115Starch and sucrose metabolism_Homo sapiens_hsa005000.46246428
116Insulin resistance_Homo sapiens_hsa049310.45835838
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.44287755
118Prolactin signaling pathway_Homo sapiens_hsa049170.42191775
119Autoimmune thyroid disease_Homo sapiens_hsa053200.41584991
120Type I diabetes mellitus_Homo sapiens_hsa049400.41431707
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41083909
122Antigen processing and presentation_Homo sapiens_hsa046120.40913707
123Vitamin digestion and absorption_Homo sapiens_hsa049770.40114337
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39335839
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37442958
126T cell receptor signaling pathway_Homo sapiens_hsa046600.37212685
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36863720
128Inositol phosphate metabolism_Homo sapiens_hsa005620.36584846
129Pancreatic cancer_Homo sapiens_hsa052120.35293311
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35237340
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.35186803
132Synaptic vesicle cycle_Homo sapiens_hsa047210.34067216
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33740068
134Chronic myeloid leukemia_Homo sapiens_hsa052200.33336686
135Phenylalanine metabolism_Homo sapiens_hsa003600.32595808
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32580747
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31666661

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