CLCNKA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to parathyroid hormone (GO:0071107)8.48469853
2one-carbon compound transport (GO:0019755)7.95545637
3metanephric nephron tubule development (GO:0072234)7.91134699
4metanephric tubule development (GO:0072170)7.91134699
5collecting duct development (GO:0072044)7.77808493
6actin filament depolymerization (GO:0030042)7.73508585
7metanephric nephron epithelium development (GO:0072243)7.20176747
8response to copper ion (GO:0046688)7.06384731
9lysine metabolic process (GO:0006553)6.85115781
10lysine catabolic process (GO:0006554)6.85115781
11metanephric epithelium development (GO:0072207)6.55285935
12cell volume homeostasis (GO:0006884)6.42248066
13positive regulation of catenin import into nucleus (GO:0035413)6.29678619
14urate metabolic process (GO:0046415)6.25905947
15response to lead ion (GO:0010288)6.21751541
16positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)5.91727599
17response to water (GO:0009415)5.91268337
18activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)5.82294708
19drug transmembrane transport (GO:0006855)5.78143758
20mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.62651299
21cellular copper ion homeostasis (GO:0006878)5.53482211
22positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc5.50183111
23aminoglycoside antibiotic metabolic process (GO:0030647)5.48080743
24nephron tubule development (GO:0072080)5.45102854
25negative regulation of cholesterol transport (GO:0032375)5.42510934
26negative regulation of sterol transport (GO:0032372)5.42510934
27regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)5.42098036
28response to thyroid hormone (GO:0097066)5.39992885
29negative regulation of metanephros development (GO:0072217)5.37141348
30water transport (GO:0006833)5.23612334
31regulation of apoptotic process involved in morphogenesis (GO:1902337)5.21094238
32NADH metabolic process (GO:0006734)5.09825500
33organic cation transport (GO:0015695)5.07142315
34drug transport (GO:0015893)5.00369047
35phosphate ion transport (GO:0006817)4.99936122
36aspartate family amino acid catabolic process (GO:0009068)4.95463970
37tryptophan metabolic process (GO:0006568)4.88205369
38transepithelial transport (GO:0070633)4.83398409
39cardiovascular system development (GO:0072358)4.77570801
40regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.77102823
412-oxoglutarate metabolic process (GO:0006103)4.77002921
42renal tubule development (GO:0061326)4.73280973
43response to magnesium ion (GO:0032026)4.69776473
44fluid transport (GO:0042044)4.67151303
45negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.63938469
46cysteine metabolic process (GO:0006534)4.51715731
47pattern specification involved in kidney development (GO:0061004)4.51318387
48tricarboxylic acid metabolic process (GO:0072350)4.50228188
49sodium-independent organic anion transport (GO:0043252)4.48164968
50glyoxylate metabolic process (GO:0046487)4.46124774
51branched-chain amino acid metabolic process (GO:0009081)4.45830340
52phosphate ion transmembrane transport (GO:0035435)4.41056579
53nephron epithelium development (GO:0072009)4.37532594
54response to growth hormone (GO:0060416)4.36860340
55response to vitamin A (GO:0033189)4.31511621
56quaternary ammonium group transport (GO:0015697)4.30420964
57regulation of protein localization to cell surface (GO:2000008)4.29465596
58branched-chain amino acid catabolic process (GO:0009083)4.28163538
59renal system process (GO:0003014)4.22525262
60hyperosmotic response (GO:0006972)4.22300612
61bone remodeling (GO:0046849)4.21263206
62sodium ion homeostasis (GO:0055078)4.20408897
63copper ion homeostasis (GO:0055070)4.13483432
64glycoside metabolic process (GO:0016137)4.08959232
65cellular response to ammonium ion (GO:0071242)4.08069811
66urogenital system development (GO:0001655)3.96577739
67amino-acid betaine metabolic process (GO:0006577)3.88251718
68short-chain fatty acid metabolic process (GO:0046459)3.87281054
69ERK1 and ERK2 cascade (GO:0070371)3.85394982
70valine metabolic process (GO:0006573)3.85175902
71mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.82578851
72response to salt stress (GO:0009651)3.81948556
73tricarboxylic acid cycle (GO:0006099)3.80993332
74modified amino acid transport (GO:0072337)3.80632569
75protein depolymerization (GO:0051261)3.77420446
76mammary gland alveolus development (GO:0060749)3.74237743
77nephron tubule morphogenesis (GO:0072078)3.72593508
78nephron epithelium morphogenesis (GO:0072088)3.72593508
79homocysteine metabolic process (GO:0050667)3.68950544
80carnitine transport (GO:0015879)3.68414562
81amino-acid betaine transport (GO:0015838)3.68414562
82cellular potassium ion homeostasis (GO:0030007)3.68189724
83regulation of somitogenesis (GO:0014807)3.67424649
84glomerular visceral epithelial cell development (GO:0072015)3.62506392
85inositol metabolic process (GO:0006020)3.62213810
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.59694544
87L-phenylalanine metabolic process (GO:0006558)3.59694544
88positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.59399890
89cellular ketone body metabolic process (GO:0046950)3.58492149
90tryptophan catabolic process (GO:0006569)3.57328738
91indole-containing compound catabolic process (GO:0042436)3.57328738
92indolalkylamine catabolic process (GO:0046218)3.57328738
93carnitine metabolic process (GO:0009437)3.57228861
94biotin metabolic process (GO:0006768)3.56353971
95kynurenine metabolic process (GO:0070189)3.54636933
96sodium ion transport (GO:0006814)3.53069705
97regulation of potassium ion transmembrane transporter activity (GO:1901016)3.52681982
98fatty acid beta-oxidation (GO:0006635)3.50663809
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.50057987
100L-phenylalanine catabolic process (GO:0006559)3.50057987
101indolalkylamine metabolic process (GO:0006586)3.49787099
102regulation of mesenchymal cell apoptotic process (GO:2001053)3.46725671
103indole-containing compound metabolic process (GO:0042430)3.46210121
104copper ion transport (GO:0006825)3.44315005
105regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.44217619
106positive regulation of heat generation (GO:0031652)3.44028709
107cell differentiation involved in metanephros development (GO:0072202)3.43821987
108tyrosine metabolic process (GO:0006570)3.43132257
109serine family amino acid catabolic process (GO:0009071)3.42595578
110fructose metabolic process (GO:0006000)3.41900619
111aromatic amino acid family catabolic process (GO:0009074)3.40036953
112nonribosomal peptide biosynthetic process (GO:0019184)3.39323574
113ATP synthesis coupled proton transport (GO:0015986)3.38260499
114energy coupled proton transport, down electrochemical gradient (GO:0015985)3.38260499
115aromatic amino acid family metabolic process (GO:0009072)3.37667922
116mesonephros development (GO:0001823)3.33580063
117calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.32650424
118fatty acid oxidation (GO:0019395)3.29872176
119glomerular epithelial cell development (GO:0072310)3.29723468
120trivalent inorganic anion homeostasis (GO:0072506)3.29657861
121phosphate ion homeostasis (GO:0055062)3.29657861
122bicarbonate transport (GO:0015701)3.27122736
123regulation of stem cell maintenance (GO:2000036)3.26308771
124lipid oxidation (GO:0034440)3.22776747
125regulation of fever generation (GO:0031620)3.21322517
126multicellular organismal water homeostasis (GO:0050891)3.19361957
127sodium ion export (GO:0071436)3.18219624
128cellular modified amino acid catabolic process (GO:0042219)3.17714250
129S-adenosylmethionine metabolic process (GO:0046500)3.17291618
130serine family amino acid metabolic process (GO:0009069)3.14646434
131positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.13972708
132regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.11524748
133vitamin transport (GO:0051180)3.11383569
134glutathione biosynthetic process (GO:0006750)3.08691331
135beta-amyloid metabolic process (GO:0050435)3.08585609
136positive regulation of digestive system process (GO:0060456)3.07215508
137regulation of catenin import into nucleus (GO:0035412)3.06562765
138hyperosmotic salinity response (GO:0042538)3.05962393
139negative regulation of kidney development (GO:0090185)3.05308041
140ketone body metabolic process (GO:1902224)3.04104129
141nephron tubule formation (GO:0072079)3.03817023
142regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.02310707
143regulation of cholesterol efflux (GO:0010874)3.00450920
144regulation of heat generation (GO:0031650)2.97855406
145positive regulation of ERBB signaling pathway (GO:1901186)2.94111831
146regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.91937218
147kidney epithelium development (GO:0072073)2.90000277
148cellular hyperosmotic response (GO:0071474)2.89774807
149L-methionine salvage (GO:0071267)2.88678964
150L-methionine biosynthetic process (GO:0071265)2.88678964
151amino acid salvage (GO:0043102)2.88678964
152regulation of potassium ion transmembrane transport (GO:1901379)2.87632868
153response to lithium ion (GO:0010226)2.84647173
154membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.84161198
155* inorganic anion transport (GO:0015698)2.74895227
156sulfur compound transport (GO:0072348)2.71729630
157polyol transport (GO:0015791)12.6226034
158* excretion (GO:0007588)11.0744145
159renal absorption (GO:0070293)10.7908011
160response to mercury ion (GO:0046689)10.6440709

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.61530051
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.77789999
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.47944623
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.22675400
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.96696701
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.59575021
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.35104337
8ESR1_21235772_ChIP-Seq_MCF-7_Human3.18139275
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.99304127
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.70837434
11NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.48942268
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.47160464
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45733854
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.36520295
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32427986
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.30690184
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.27982354
18CLOCK_20551151_ChIP-Seq_293T_Human2.27579836
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.16867292
20AR_21909140_ChIP-Seq_LNCAP_Human2.09509315
21STAT3_1855785_ChIP-Seq_MESCs_Mouse2.04387629
22DROSHA_22980978_ChIP-Seq_HELA_Human2.01224979
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93348033
24ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.90142398
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.89855682
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.89141712
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83028195
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81124497
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76022986
30SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.72640719
31RACK7_27058665_Chip-Seq_MCF-7_Human1.69051619
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69026513
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.66876565
34GATA4_25053715_ChIP-Seq_YYC3_Human1.66432495
35TCF4_18268006_ChIP-ChIP_LS174T_Human1.63545140
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.58655952
37EGR1_19032775_ChIP-ChIP_M12_Human1.54827382
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54722629
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.53378703
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.53366307
41SOX11_22085726_ChIP-Seq_ESNs_Mouse1.52676108
42ZNF263_19887448_ChIP-Seq_K562_Human1.52376301
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51956742
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.50796378
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.50796378
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49161091
47KLF4_18555785_Chip-Seq_ESCs_Mouse1.49131569
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48881466
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.47804152
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47254700
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47042937
52NFIB_24661679_ChIP-Seq_LUNG_Mouse1.46493884
53GBX2_23144817_ChIP-Seq_PC3_Human1.46137646
54FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.44083392
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41358468
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41140044
57SOX2_20726797_ChIP-Seq_SW620_Human1.37523479
58NANOG_18692474_ChIP-Seq_MEFs_Mouse1.36100309
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35594335
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35241812
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34954124
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34389290
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33701378
64GATA6_25053715_ChIP-Seq_YYC3_Human1.31485533
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30951562
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.30210371
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28534785
68ATF3_27146783_Chip-Seq_COLON_Human1.28356702
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.27198199
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26817177
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26709996
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25564805
73SMAD4_21799915_ChIP-Seq_A2780_Human1.25323740
74E2F1_18555785_Chip-Seq_ESCs_Mouse1.25025818
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24711921
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24523776
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23947619
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23690915
79EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.22916453
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22808755
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22741827
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22648057
83VDR_22108803_ChIP-Seq_LS180_Human1.21651694
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.21327083
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.21314833
86TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.21185061
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.20276769
88NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19506791
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18694937
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16894324
91CBP_21632823_ChIP-Seq_H3396_Human1.16381552
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15020267
93RNF2_27304074_Chip-Seq_ESCs_Mouse1.14952550
94EED_16625203_ChIP-ChIP_MESCs_Mouse1.14423698
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.13796850
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13714331
97SMAD3_21741376_ChIP-Seq_HESCs_Human1.13052923
98LXR_22292898_ChIP-Seq_THP-1_Human1.12806922
99* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12229147
100EOMES_21245162_ChIP-Seq_HESCs_Human1.12120419
101STAT3_18555785_Chip-Seq_ESCs_Mouse1.11977630
102GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.11964738
103HNF4A_19822575_ChIP-Seq_HepG2_Human1.10888375
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.09670832
105* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09238932
106* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.07980457
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07608577
108ZFX_18555785_Chip-Seq_ESCs_Mouse1.07142850
109P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06614101
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05186037
111TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.04572668
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03650848
113OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03442866
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03286494
115STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02653693
116RUNX1_27514584_Chip-Seq_MCF-7_Human1.01249429
117CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01243428
118P300_18555785_Chip-Seq_ESCs_Mouse1.00444318
119GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00310212
120KDM2B_26808549_Chip-Seq_REH_Human1.00207408
121TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00012379
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99859598
123* PHF8_20622853_ChIP-Seq_HELA_Human0.99288426
124PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98761570
125SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98505877
126* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97827662
127SMAD4_21741376_ChIP-Seq_EPCs_Human0.97497533
128RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97020495
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96642514
130RXR_22108803_ChIP-Seq_LS180_Human0.96194402
131* TBL1_22424771_ChIP-Seq_293T_Human0.96170359
132FOXA2_19822575_ChIP-Seq_HepG2_Human0.95956595
133CDX2_22108803_ChIP-Seq_LS180_Human0.95762719
134ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95758921
135NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95629693
136P53_22387025_ChIP-Seq_ESCs_Mouse0.95486942
137SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95209939
138SMAD4_21741376_ChIP-Seq_HESCs_Human0.95146862
139TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95049035
140TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94608706
141* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93558477
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93497770
143CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92626658
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91762690
145CTCF_27219007_Chip-Seq_Bcells_Human0.91464234
146SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91259323
147TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90930740
148SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90702202
149PU1_27457419_Chip-Seq_LIVER_Mouse0.90135601
150BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90069059
151RAC3_21632823_ChIP-Seq_H3396_Human0.89494986
152CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89136359
153* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88905472
154P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88276733
155AHR_22903824_ChIP-Seq_MCF-7_Human0.88224143
156OCT4_20526341_ChIP-Seq_ESCs_Human0.88182974
157TET1_21490601_ChIP-Seq_MESCs_Mouse0.88137614
158EZH2_22144423_ChIP-Seq_EOC_Human0.88109457
159TBX20_22328084_ChIP-Seq_HEART_Mouse0.87677973
160TBX20_22080862_ChIP-Seq_HEART_Mouse0.87677973
161NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87287210
162ERG_20517297_ChIP-Seq_VCAP_Human0.86433552
163TP63_22573176_ChIP-Seq_HFKS_Human0.85919155
164KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85873492
165TP53_22127205_ChIP-Seq_IMR90_Human0.85805941
166TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.85353865
167* FOXH1_21741376_ChIP-Seq_ESCs_Human0.85208648
168POU5F1_16518401_ChIP-PET_MESCs_Mouse0.84234304
169NANOG_18692474_ChIP-Seq_MESCs_Mouse0.83083248
170VDR_24787735_ChIP-Seq_THP-1_Human0.82608487
171CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82607647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation9.79274086
2MP0003195_calcinosis8.01705852
3* MP0001756_abnormal_urination5.78677171
4MP0001765_abnormal_ion_homeostasis3.80977566
5MP0005360_urolithiasis3.78929865
6MP0005332_abnormal_amino_acid3.71353040
7* MP0009643_abnormal_urine_homeostasis3.70606029
8MP0004885_abnormal_endolymph3.48833334
9MP0005636_abnormal_mineral_homeostasis3.18673908
10* MP0002136_abnormal_kidney_physiology2.92573335
11MP0004019_abnormal_vitamin_homeostasis2.76655735
12MP0002138_abnormal_hepatobiliary_system2.56394296
13MP0002139_abnormal_hepatobiliary_system2.46748004
14MP0002168_other_aberrant_phenotype2.41537670
15MP0010234_abnormal_vibrissa_follicle2.11825138
16MP0000538_abnormal_urinary_bladder2.00701868
17MP0003300_gastrointestinal_ulcer1.74794943
18MP0005395_other_phenotype1.73529174
19MP0005670_abnormal_white_adipose1.66580502
20MP0005377_hearing/vestibular/ear_phenot1.60826376
21MP0003878_abnormal_ear_physiology1.60826376
22MP0008961_abnormal_basal_metabolism1.50557608
23MP0004742_abnormal_vestibular_system1.38296164
24MP0000534_abnormal_ureter_morphology1.37637957
25MP0003186_abnormal_redox_activity1.37314329
26MP0003252_abnormal_bile_duct1.36567074
27MP0001177_atelectasis1.35583947
28MP0008875_abnormal_xenobiotic_pharmacok1.30686617
29MP0005451_abnormal_body_composition1.30076156
30MP0003806_abnormal_nucleotide_metabolis1.25732492
31MP0003045_fibrosis1.24757834
32MP0005085_abnormal_gallbladder_physiolo1.24688633
33MP0003329_amyloid_beta_deposits1.23818624
34MP0005584_abnormal_enzyme/coenzyme_acti1.22542492
35MP0000230_abnormal_systemic_arterial1.20122521
36MP0002098_abnormal_vibrissa_morphology1.16384590
37MP0002234_abnormal_pharynx_morphology1.14866697
38MP0001270_distended_abdomen1.14778838
39MP0001958_emphysema1.13295651
40MP0005408_hypopigmentation1.11773679
41MP0000747_muscle_weakness1.09011324
42MP0002896_abnormal_bone_mineralization1.08605999
43MP0000371_diluted_coat_color1.06283726
44MP0006036_abnormal_mitochondrial_physio1.05867787
45MP0005319_abnormal_enzyme/_coenzyme1.05859627
46MP0005171_absent_coat_pigmentation1.02234859
47MP0002135_abnormal_kidney_morphology1.00337563
48MP0005220_abnormal_exocrine_pancreas0.97974714
49MP0002163_abnormal_gland_morphology0.95331925
50MP0005365_abnormal_bile_salt0.93120921
51MP0002089_abnormal_postnatal_growth/wei0.89739809
52MP0003646_muscle_fatigue0.83721769
53MP0010386_abnormal_urinary_bladder0.83417938
54MP0005058_abnormal_lysosome_morphology0.81941116
55MP0002133_abnormal_respiratory_system0.81628540
56MP0005388_respiratory_system_phenotype0.81628540
57MP0009672_abnormal_birth_weight0.81255002
58MP0008872_abnormal_physiological_respon0.80860118
59MP0000372_irregular_coat_pigmentation0.80197701
60MP0001764_abnormal_homeostasis0.79700055
61MP0005535_abnormal_body_temperature0.76934352
62MP0003718_maternal_effect0.76225590
63MP0000681_abnormal_thyroid_gland0.75777854
64MP0005503_abnormal_tendon_morphology0.74025499
65MP0001485_abnormal_pinna_reflex0.73804488
66MP0008004_abnormal_stomach_pH0.72317000
67MP0003638_abnormal_response/metabolism_0.71638216
68MP0003283_abnormal_digestive_organ0.70896857
69MP0004264_abnormal_extraembryonic_tissu0.66644250
70MP0003183_abnormal_peptide_metabolism0.65103562
71MP0006035_abnormal_mitochondrial_morpho0.64009582
72MP0002796_impaired_skin_barrier0.63172803
73MP0005666_abnormal_adipose_tissue0.63098962
74MP0005275_abnormal_skin_tensile0.61278019
75MP0003191_abnormal_cellular_cholesterol0.60437548
76MP0002928_abnormal_bile_duct0.59791937
77MP0001661_extended_life_span0.59611482
78MP0002876_abnormal_thyroid_physiology0.59224135
79MP0004215_abnormal_myocardial_fiber0.58987183
80MP0003315_abnormal_perineum_morphology0.58826763
81MP0004084_abnormal_cardiac_muscle0.57931495
82MP0009642_abnormal_blood_homeostasis0.55417214
83MP0003795_abnormal_bone_structure0.55221090
84MP0008438_abnormal_cutaneous_collagen0.54625081
85MP0004272_abnormal_basement_membrane0.53167937
86MP0000604_amyloidosis0.52326906
87MP0002118_abnormal_lipid_homeostasis0.51567151
88MP0002069_abnormal_eating/drinking_beha0.51190478
89MP0003879_abnormal_hair_cell0.50572061
90MP0000678_abnormal_parathyroid_gland0.49975326
91MP0008260_abnormal_autophagy0.49331705
92MP0001963_abnormal_hearing_physiology0.48476409
93MP0003137_abnormal_impulse_conducting0.45620658
94MP0005375_adipose_tissue_phenotype0.44997422
95MP0002971_abnormal_brown_adipose0.44575319
96MP0000609_abnormal_liver_physiology0.44187358
97MP0010368_abnormal_lymphatic_system0.43679524
98MP0002132_abnormal_respiratory_system0.42515373
99MP0003938_abnormal_ear_development0.42374747
100MP0004233_abnormal_muscle_weight0.41904948
101MP0003953_abnormal_hormone_level0.41630005
102MP0009703_decreased_birth_body0.40766841
103MP0005501_abnormal_skin_physiology0.39847584
104MP0000026_abnormal_inner_ear0.39798471
105MP0003943_abnormal_hepatobiliary_system0.39652393
106MP0003959_abnormal_lean_body0.39487742
107MP0001731_abnormal_postnatal_growth0.39431792
108MP0003566_abnormal_cell_adhesion0.38646227
109MP0000462_abnormal_digestive_system0.38279406
110MP0001727_abnormal_embryo_implantation0.37977482
111MP0002108_abnormal_muscle_morphology0.36986958
112MP0000003_abnormal_adipose_tissue0.35529563
113MP0009697_abnormal_copulation0.34882047
114MP0004036_abnormal_muscle_relaxation0.33235310
115MP0001944_abnormal_pancreas_morphology0.33153946
116MP0000631_abnormal_neuroendocrine_gland0.33028948
117MP0009840_abnormal_foam_cell0.32936899
118MP0001666_abnormal_nutrient_absorption0.32934344
119MP0000013_abnormal_adipose_tissue0.32698121
120MP0001191_abnormal_skin_condition0.32416741
121MP0002115_abnormal_skeleton_extremities0.31316799
122MP0005330_cardiomyopathy0.31086503
123MP0003632_abnormal_nervous_system0.29273591
124MP0000566_synostosis0.29119419
125MP0000367_abnormal_coat/_hair0.29107580
126MP0000750_abnormal_muscle_regeneration0.29101428
127MP0005084_abnormal_gallbladder_morpholo0.29085090
128MP0002295_abnormal_pulmonary_circulatio0.29030653
129MP0000163_abnormal_cartilage_morphology0.29016949
130MP0003941_abnormal_skin_development0.28950680
131MP0009780_abnormal_chondrocyte_physiolo0.28835163
132MP0000762_abnormal_tongue_morphology0.27966286
133MP0003011_delayed_dark_adaptation0.27303498
134MP0008775_abnormal_heart_ventricle0.26801972
135MP0002972_abnormal_cardiac_muscle0.23759941
136MP0004484_altered_response_of0.22508808
137MP0002082_postnatal_lethality0.22070172
138MP0010770_preweaning_lethality0.22070172
139MP0002127_abnormal_cardiovascular_syste0.20065331
140MP0002998_abnormal_bone_remodeling0.20024593
141MP0002249_abnormal_larynx_morphology0.18984579
142MP0004085_abnormal_heartbeat0.18476877
143MP0010769_abnormal_survival0.18059000
144MP0002078_abnormal_glucose_homeostasis0.16883054

Predicted human phenotypes

RankGene SetZ-score
1* Abnormality of chloride homeostasis (HP:0011422)9.10379761
2Increased circulating renin level (HP:0000848)8.73746890
3* Renal salt wasting (HP:0000127)8.20271496
4* Hyperaldosteronism (HP:0000859)8.03678317
5Hypomagnesemia (HP:0002917)7.96326245
6* Polyuria (HP:0000103)7.66664819
7* Abnormal urine output (HP:0012590)7.04392640
8Abnormality of magnesium homeostasis (HP:0004921)6.77287010
9Abnormality of renin-angiotensin system (HP:0000847)6.71416114
10Abnormal drinking behavior (HP:0030082)6.42231048
11Polydipsia (HP:0001959)6.42231048
12* Alkalosis (HP:0001948)6.30105601
13Tetany (HP:0001281)6.25382631
14* Abnormality of renal excretion (HP:0011036)6.24441212
15* Hypokalemia (HP:0002900)5.02294439
16Gout (HP:0001997)4.73174115
17Decreased circulating renin level (HP:0003351)4.67891429
18* Abnormality of sodium homeostasis (HP:0010931)4.45313764
19* Abnormality of potassium homeostasis (HP:0011042)3.99298296
20Hypercalciuria (HP:0002150)3.90545845
21* Hyponatremia (HP:0002902)3.75296595
22* Adrenal overactivity (HP:0002717)3.70250600
23Abnormality of fatty-acid metabolism (HP:0004359)3.55966475
24Chondrocalcinosis (HP:0000934)3.39343082
25Dehydration (HP:0001944)3.33580659
26Hyperuricemia (HP:0002149)3.22942750
27Increased purine levels (HP:0004368)3.22942750
28Abnormality of Sharpey fibers (HP:0100685)3.22007247
29Hypotension (HP:0002615)3.13529101
30Hyperkalemia (HP:0002153)2.85343210
31Hyperglycinuria (HP:0003108)2.76730264
32Nephrocalcinosis (HP:0000121)2.72592407
33Chronic bronchitis (HP:0004469)2.71732760
34Renal tubular acidosis (HP:0001947)2.60890218
35Abnormality of purine metabolism (HP:0004352)2.48080350
36Tubulointerstitial fibrosis (HP:0005576)2.41872080
37Proximal tubulopathy (HP:0000114)2.28690363
38Large eyes (HP:0001090)2.21750681
39Abnormality of glycine metabolism (HP:0010895)2.21639599
40Abnormality of serine family amino acid metabolism (HP:0010894)2.21639599
41Glycosuria (HP:0003076)2.15400989
42Abnormality of urine glucose concentration (HP:0011016)2.15400989
43Neonatal onset (HP:0003623)2.12718421
44Generalized muscle weakness (HP:0003324)2.08553048
45Vomiting (HP:0002013)2.06513349
46Hyperactive renin-angiotensin system (HP:0000841)11.3874580
47* Hypokalemic alkalosis (HP:0001949)11.3009017
48* Metabolic alkalosis (HP:0200114)10.1720503
49Renal tubular dysfunction (HP:0000124)1.96201232
50Ketoacidosis (HP:0001993)1.96042604
51Abnormality of glutamine family amino acid metabolism (HP:0010902)1.92704995
52Rickets (HP:0002748)1.89192078
53Hyperphosphaturia (HP:0003109)1.88419653
54Conjugated hyperbilirubinemia (HP:0002908)1.82491260
55Ileus (HP:0002595)1.81551537
56Abnormality of cochlea (HP:0000375)1.81160129
57Vascular calcification (HP:0004934)1.80484472
58Metabolic acidosis (HP:0001942)1.76359104
59Abnormality of nucleobase metabolism (HP:0010932)1.76059600
60Hypophosphatemia (HP:0002148)1.75463373
61Hyperglycinemia (HP:0002154)1.72885170
62Spinal muscular atrophy (HP:0007269)1.67651977
63Impaired platelet aggregation (HP:0003540)1.67618707
64Abnormal platelet function (HP:0011869)1.67618707
65Abnormal urine phosphate concentration (HP:0012599)1.65252959
66Generalized aminoaciduria (HP:0002909)1.62302381
67Nephrogenic diabetes insipidus (HP:0009806)1.59827738
68Ketosis (HP:0001946)1.59722741
69Cardiovascular calcification (HP:0011915)1.59443769
70Glomerulosclerosis (HP:0000096)1.56977612
71Abnormality of the renal cortex (HP:0011035)1.55711323
72Tubular atrophy (HP:0000092)1.50804874
73Irritability (HP:0000737)1.49103247
74Nephrolithiasis (HP:0000787)1.47806426
75Facial shape deformation (HP:0011334)1.46136870
76Potter facies (HP:0002009)1.46136870
77Focal segmental glomerulosclerosis (HP:0000097)1.41669765
78Delayed CNS myelination (HP:0002188)1.39759788
79Tubulointerstitial abnormality (HP:0001969)1.37918506
80Hyperammonemia (HP:0001987)1.37024471
81Osteopenia (HP:0000938)1.36948977
82Thyroid-stimulating hormone excess (HP:0002925)1.35517591
83Abnormality of calcium-phosphate metabolism (HP:0100530)1.34023697
84Abnormality of the renal medulla (HP:0100957)1.32974131
85Dicarboxylic aciduria (HP:0003215)1.28720142
86Abnormality of dicarboxylic acid metabolism (HP:0010995)1.28720142
87Abnormality of the right ventricle (HP:0001707)1.28174778
88Abnormality of renal resorption (HP:0011038)1.26975982
89Neonatal death (HP:0003811)1.26681769
90Lethargy (HP:0001254)1.24634101
91Intellectual disability, moderate (HP:0002342)1.22754196
92Enlarged kidneys (HP:0000105)1.21142647
93Abnormality of proline metabolism (HP:0010907)1.19859985
94Hydroxyprolinuria (HP:0003080)1.19859985
95Morphological abnormality of the inner ear (HP:0011390)1.19505225
96Paresthesia (HP:0003401)1.19306295
97Elevated alkaline phosphatase (HP:0003155)1.18103900
98Metaphyseal dysplasia (HP:0100255)1.18054018
99Abnormality of alkaline phosphatase activity (HP:0004379)1.16767758
100Abnormal enzyme/coenzyme activity (HP:0012379)1.15828207
101Abnormality of aspartate family amino acid metabolism (HP:0010899)1.11236593
102Male infertility (HP:0003251)1.07403434
103Abnormality of carpal bone ossification (HP:0006257)1.05821196
104Hypothermia (HP:0002045)1.05267784
105Osteomalacia (HP:0002749)1.04836126
106Delayed epiphyseal ossification (HP:0002663)1.04071552
107Metaphyseal cupping (HP:0003021)1.03356423
108Bilateral sensorineural hearing impairment (HP:0008619)1.02762272
109Thin bony cortex (HP:0002753)1.01692958
110Abnormality of sulfur amino acid metabolism (HP:0004339)1.01249419
111Esophageal varix (HP:0002040)1.00814038
112Bicornuate uterus (HP:0000813)1.00498807
113* Premature birth (HP:0001622)0.98217693
114Small for gestational age (HP:0001518)0.97266528
115Increased muscle lipid content (HP:0009058)0.97001887
116Increased intramyocellular lipid droplets (HP:0012240)0.96168020
117Spontaneous hematomas (HP:0007420)0.95315770
118Goiter (HP:0000853)0.94311106
119Lymphangioma (HP:0100764)0.93948130
120Hyperphosphatemia (HP:0002905)0.92514388
121Abnormal tarsal ossification (HP:0008369)0.88143784
122Hypophosphatemic rickets (HP:0004912)0.85281121
123Persistence of primary teeth (HP:0006335)0.83776017
124* Polyhydramnios (HP:0001561)0.83066285
125Abnormal hand bone ossification (HP:0010660)0.81270638
126Abnormality of macular pigmentation (HP:0008002)0.80205012
127Abnormality of the fingertips (HP:0001211)0.79805023
128Enlarged epiphyses (HP:0010580)0.78743785
129Abnormal ossification of hand bones (HP:0005921)0.76946088
130Confusion (HP:0001289)0.72856214

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OXSR17.32334651
2WNK45.53187656
3LMTK24.06673735
4SGK22.03364586
5STK392.01589384
6WNK312.1510960
7BCKDK1.91818906
8SGK2231.90913691
9SGK4941.90913691
10STK38L1.72838000
11SGK31.64888143
12PDK31.46239949
13PDK41.46239949
14PDK21.35556259
15MAP3K31.33662172
16WNK11.32781454
17NEK11.07828071
18PRKG20.82329701
19MST1R0.69841138
20TAOK10.68222235
21STK380.68113548
22MST40.67565429
23PRKAA10.64392422
24EPHA20.62161689
25BUB10.61632560
26PAK40.57459065
27TIE10.51349856
28PINK10.50570044
29MAP3K110.49847928
30MAPK150.49828463
31ERN10.49591330
32MAP2K30.47759204
33TTK0.46862465
34LRRK20.45731422
35RIPK10.42229541
36SGK10.41908847
37MAP3K70.39576826
38STK100.37230335
39WEE10.35202563
40MAP3K20.33328643
41AKT30.31745302
42TAOK20.28945392
43EIF2AK30.27047792
44PRKCI0.26056805
45INSRR0.25351351
46GRK60.25250487
47TESK10.23873670
48NLK0.23567389
49CSNK1A10.23488722
50CDC42BPA0.23278622
51ABL20.22304737
52DMPK0.21840665
53TSSK60.21801670
54GSK3A0.21504498
55DDR20.20516534
56FRK0.19928819
57ROCK10.19629699
58MARK30.18719887
59FER0.18563685
60SCYL20.18402395
61PRPF4B0.17776455
62TRIB30.17540100
63MET0.17283455
64SRPK10.16262179
65PIK3CG0.16062715
66PTK20.15287846
67PTK60.15239768
68NME10.15174747
69PRKCD0.15168698
70TGFBR20.14575496
71OBSCN0.14314952
72PNCK0.13868600
73MAP3K80.13787364
74KSR20.12807429
75ACVR1B0.12619514
76EIF2AK10.12313070
77PDPK10.12212492
78PRKACG0.10904376
79NTRK10.10438165
80BRSK20.10078120
81PRKACA0.09728923
82MAPKAPK30.07617160
83MTOR0.07277784
84PRKCZ0.07174309
85PRKD30.07015445
86FGFR20.06972739
87EPHB10.06489893
88PAK30.06337030
89AURKB0.05544304
90RPS6KA30.05480747
91PDK10.05140303
92NEK20.05115331
93IRAK20.05064938
94UHMK10.04845052
95NTRK30.04765804
96ZAK0.04668414
97LATS10.04514729
98RET0.04445206
99ROCK20.04357276
100LATS20.04337403
101PRKCA0.04007803
102SRC0.03812175
103BRD40.03676668
104FGFR40.03468396
105STK110.03371278
106STK240.03349001
107PRKCH0.03239340
108MELK0.03212538
109AURKA0.02809756
110NME20.02557004
111PRKCB0.02543771
112DAPK10.02020795
113MAPK100.01564753
114PRKCG0.01442142
115CSNK1G10.01415661
116AKT20.01293087
117FGFR30.00909133
118PIM10.00726616
119MYLK0.00241438
120MUSK-0.0640405
121MAP2K1-0.0640149
122YES1-0.0574980
123ERBB2-0.0549329
124RPS6KA2-0.0454780
125MAPK1-0.0454656
126GSK3B-0.0450288
127TRPM7-0.0404225
128MINK1-0.0399583
129MAPK8-0.0399364
130PRKAA2-0.0367504
131BMPR1B-0.0361394
132PDGFRA-0.0340619
133MAP2K2-0.0334499
134TAF1-0.0333549
135PRKG1-0.0325849
136PRKACB-0.0322746
137MARK2-0.0320074
138PDGFRB-0.0294906
139CSNK1G2-0.0238034
140TGFBR1-0.0235432
141CDK6-0.0164686
142PRKCE-0.0144752
143STK3-0.0138168
144KSR1-0.0106070
145PRKD1-0.0104147
146PRKD2-0.0062552

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049644.38205956
2Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.89862873
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.73898737
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.20870313
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.11670573
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.04622489
7Propanoate metabolism_Homo sapiens_hsa006403.02135691
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.79375003
9Butanoate metabolism_Homo sapiens_hsa006502.69643074
10Fatty acid degradation_Homo sapiens_hsa000712.56301649
11Sulfur metabolism_Homo sapiens_hsa009202.41923140
12Collecting duct acid secretion_Homo sapiens_hsa049662.41689336
13Mineral absorption_Homo sapiens_hsa049782.19737322
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.13139726
15Cyanoamino acid metabolism_Homo sapiens_hsa004602.05823854
16Bile secretion_Homo sapiens_hsa049762.05005968
17Carbon metabolism_Homo sapiens_hsa012001.99369934
18Oxidative phosphorylation_Homo sapiens_hsa001901.93678278
19Pyruvate metabolism_Homo sapiens_hsa006201.93023570
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.86262355
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.85288702
22Peroxisome_Homo sapiens_hsa041461.83353261
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75947523
24Fatty acid metabolism_Homo sapiens_hsa012121.71156594
25Vitamin digestion and absorption_Homo sapiens_hsa049771.67566809
26Bladder cancer_Homo sapiens_hsa052191.66875813
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.65422988
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64295153
29Tryptophan metabolism_Homo sapiens_hsa003801.62838989
30Parkinsons disease_Homo sapiens_hsa050121.41656816
31beta-Alanine metabolism_Homo sapiens_hsa004101.39516193
32Glutathione metabolism_Homo sapiens_hsa004801.32388076
33Biosynthesis of amino acids_Homo sapiens_hsa012301.29981772
34Endometrial cancer_Homo sapiens_hsa052131.23952126
35Gastric acid secretion_Homo sapiens_hsa049711.19437208
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17943551
37Arginine biosynthesis_Homo sapiens_hsa002201.09555894
38Regulation of autophagy_Homo sapiens_hsa041401.09159213
39Protein digestion and absorption_Homo sapiens_hsa049741.06151752
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03355642
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02320816
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.01127906
43Non-small cell lung cancer_Homo sapiens_hsa052231.00452815
44Alzheimers disease_Homo sapiens_hsa050100.97272776
45Cardiac muscle contraction_Homo sapiens_hsa042600.95136104
46Glycerolipid metabolism_Homo sapiens_hsa005610.93407734
47PPAR signaling pathway_Homo sapiens_hsa033200.92094187
48Fatty acid elongation_Homo sapiens_hsa000620.91256251
49Arginine and proline metabolism_Homo sapiens_hsa003300.91126094
50Pancreatic cancer_Homo sapiens_hsa052120.90999990
51Fructose and mannose metabolism_Homo sapiens_hsa000510.90555840
52Folate biosynthesis_Homo sapiens_hsa007900.86112778
53Huntingtons disease_Homo sapiens_hsa050160.85326621
54Melanoma_Homo sapiens_hsa052180.84465649
55Vibrio cholerae infection_Homo sapiens_hsa051100.84074071
56Glioma_Homo sapiens_hsa052140.83732865
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83452345
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81778800
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81049883
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76325176
61Vitamin B6 metabolism_Homo sapiens_hsa007500.75735712
62Other glycan degradation_Homo sapiens_hsa005110.75560727
63Nitrogen metabolism_Homo sapiens_hsa009100.75477244
64Lysosome_Homo sapiens_hsa041420.71673194
65Pentose phosphate pathway_Homo sapiens_hsa000300.70650285
66Lysine degradation_Homo sapiens_hsa003100.70500657
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.70431298
68Selenocompound metabolism_Homo sapiens_hsa004500.68990194
69ABC transporters_Homo sapiens_hsa020100.67917029
70Phenylalanine metabolism_Homo sapiens_hsa003600.64410513
71Gap junction_Homo sapiens_hsa045400.64033127
72Thyroid hormone synthesis_Homo sapiens_hsa049180.63506562
73Thyroid cancer_Homo sapiens_hsa052160.62712281
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62690291
75Metabolic pathways_Homo sapiens_hsa011000.60328058
76Prostate cancer_Homo sapiens_hsa052150.57949362
77Focal adhesion_Homo sapiens_hsa045100.57111767
78FoxO signaling pathway_Homo sapiens_hsa040680.55204576
79ECM-receptor interaction_Homo sapiens_hsa045120.54167382
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54054533
81Renin-angiotensin system_Homo sapiens_hsa046140.53388165
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52109568
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51587364
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51260951
85Starch and sucrose metabolism_Homo sapiens_hsa005000.50160765
86ErbB signaling pathway_Homo sapiens_hsa040120.49956396
87HIF-1 signaling pathway_Homo sapiens_hsa040660.49078201
88Taste transduction_Homo sapiens_hsa047420.48972017
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47914526
90Chemical carcinogenesis_Homo sapiens_hsa052040.45650763
91Complement and coagulation cascades_Homo sapiens_hsa046100.43975642
92Glucagon signaling pathway_Homo sapiens_hsa049220.43356603
93Synaptic vesicle cycle_Homo sapiens_hsa047210.40603862
94Retinol metabolism_Homo sapiens_hsa008300.37200232
95Circadian rhythm_Homo sapiens_hsa047100.35753225
96Tyrosine metabolism_Homo sapiens_hsa003500.35328977
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.34853789
98Histidine metabolism_Homo sapiens_hsa003400.33500439
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31139993
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.29352521
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27424829
102Tight junction_Homo sapiens_hsa045300.26122233
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25934934
104Pancreatic secretion_Homo sapiens_hsa049720.24531405
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.23805479
106Hedgehog signaling pathway_Homo sapiens_hsa043400.22680343
107Salivary secretion_Homo sapiens_hsa049700.21864112
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20870043
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.20539441
110Arachidonic acid metabolism_Homo sapiens_hsa005900.19818051
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19249323
112cAMP signaling pathway_Homo sapiens_hsa040240.17251598
113Rap1 signaling pathway_Homo sapiens_hsa040150.17122257
114Adherens junction_Homo sapiens_hsa045200.16442402
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16116429
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.13650454
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.13078328
118AMPK signaling pathway_Homo sapiens_hsa041520.10686344
119Galactose metabolism_Homo sapiens_hsa000520.08557191
120Choline metabolism in cancer_Homo sapiens_hsa052310.07608194
121Rheumatoid arthritis_Homo sapiens_hsa053230.05452679
122Sphingolipid metabolism_Homo sapiens_hsa006000.04624152
123Hepatitis C_Homo sapiens_hsa051600.03106545
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.03026538
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.02775430
126Sulfur relay system_Homo sapiens_hsa041220.02505107
127Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0262467
128Insulin resistance_Homo sapiens_hsa04931-0.0239814

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