CLCNKB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transport (GO:0015893)8.67576531
2lysine catabolic process (GO:0006554)8.51046282
3lysine metabolic process (GO:0006553)8.51046282
4organic cation transport (GO:0015695)8.36896701
5phosphate ion transport (GO:0006817)8.34121167
6collecting duct development (GO:0072044)8.13390021
7quaternary ammonium group transport (GO:0015697)6.95831291
8response to mercury ion (GO:0046689)6.93532371
9phosphate ion transmembrane transport (GO:0035435)6.87081450
10glyoxylate metabolic process (GO:0046487)6.57052937
11actin filament depolymerization (GO:0030042)6.54083851
12drug catabolic process (GO:0042737)6.35037026
13cardiovascular system development (GO:0072358)6.33354301
14renal absorption (GO:0070293)6.31224552
15* excretion (GO:0007588)6.21906917
16positive regulation of catenin import into nucleus (GO:0035413)6.20469036
17cysteine metabolic process (GO:0006534)6.18194172
18tricarboxylic acid metabolic process (GO:0072350)6.14624588
19vitamin D metabolic process (GO:0042359)6.09630149
20exogenous drug catabolic process (GO:0042738)6.06350718
21mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)6.06262404
22metanephric nephron tubule development (GO:0072234)5.82844388
23metanephric tubule development (GO:0072170)5.82844388
24aspartate family amino acid catabolic process (GO:0009068)5.70556954
25nonribosomal peptide biosynthetic process (GO:0019184)5.47375166
26short-chain fatty acid metabolic process (GO:0046459)5.39983374
27metanephric nephron epithelium development (GO:0072243)5.39074714
28toxin transport (GO:1901998)5.27398799
29modified amino acid transport (GO:0072337)5.24475558
30homocysteine metabolic process (GO:0050667)5.21670633
31amino-acid betaine transport (GO:0015838)5.16656954
32carnitine transport (GO:0015879)5.16656954
33trivalent inorganic anion homeostasis (GO:0072506)5.16565961
34phosphate ion homeostasis (GO:0055062)5.16565961
35branched-chain amino acid metabolic process (GO:0009081)5.15138965
36metanephric epithelium development (GO:0072207)5.03575068
37cell volume homeostasis (GO:0006884)4.96721125
38valine metabolic process (GO:0006573)4.90387387
39glutathione biosynthetic process (GO:0006750)4.87295097
40response to water (GO:0009415)4.77176925
41response to lead ion (GO:0010288)4.72377178
42proline metabolic process (GO:0006560)4.71601830
43negative regulation of metanephros development (GO:0072217)4.68963789
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.66211963
45L-phenylalanine metabolic process (GO:0006558)4.66211963
46glycoside metabolic process (GO:0016137)4.66119391
472-oxoglutarate metabolic process (GO:0006103)4.64266058
48nephron tubule formation (GO:0072079)4.62564605
49serine family amino acid catabolic process (GO:0009071)4.56386544
50aromatic amino acid family catabolic process (GO:0009074)4.54073821
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.51230804
52L-phenylalanine catabolic process (GO:0006559)4.51230804
53negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.50259831
54fructose metabolic process (GO:0006000)4.48662582
55serine family amino acid metabolic process (GO:0009069)4.48495976
56positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc4.47090924
57fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.46096370
58cellular modified amino acid catabolic process (GO:0042219)4.46000051
59indole-containing compound catabolic process (GO:0042436)4.44173454
60indolalkylamine catabolic process (GO:0046218)4.44173454
61tryptophan catabolic process (GO:0006569)4.44173454
62nephron tubule development (GO:0072080)4.39855003
63pattern specification involved in kidney development (GO:0061004)4.39035327
64activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.38658223
65fatty acid beta-oxidation (GO:0006635)4.33160905
66amino-acid betaine metabolic process (GO:0006577)4.32108906
67branched-chain amino acid catabolic process (GO:0009083)4.31754081
68tryptophan metabolic process (GO:0006568)4.25836759
69regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.20717933
70acetyl-CoA metabolic process (GO:0006084)4.18041215
71polyol transport (GO:0015791)4.05684266
72NADH metabolic process (GO:0006734)4.03599950
73positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)4.01309679
74fatty acid oxidation (GO:0019395)3.97699557
75peptide biosynthetic process (GO:0043043)3.96642700
76carnitine metabolic process (GO:0009437)3.96614335
77response to parathyroid hormone (GO:0071107)3.92473641
78lipid oxidation (GO:0034440)3.89794019
79renal tubule development (GO:0061326)3.87894863
80vitamin transport (GO:0051180)3.84238044
81regulation of apoptotic process involved in morphogenesis (GO:1902337)3.83933956
82mesonephros development (GO:0001823)3.82761367
83urogenital system development (GO:0001655)3.82126374
84cellular ketone body metabolic process (GO:0046950)3.81869002
85peptide catabolic process (GO:0043171)3.77586297
86glutamate metabolic process (GO:0006536)3.76953239
87response to copper ion (GO:0046688)3.76153576
88glomerular visceral epithelial cell development (GO:0072015)3.75496848
89inositol metabolic process (GO:0006020)3.70562110
90oligosaccharide catabolic process (GO:0009313)3.69447281
91response to growth hormone (GO:0060416)3.67088306
92serine family amino acid biosynthetic process (GO:0009070)3.63920113
93sperm capacitation (GO:0048240)3.62986879
94nephron epithelium development (GO:0072009)3.62577970
95cellular amino acid catabolic process (GO:0009063)3.61925676
96sulfur compound transport (GO:0072348)3.61710578
97response to vitamin A (GO:0033189)3.60601434
98nephron epithelium morphogenesis (GO:0072088)3.59066359
99nephron tubule morphogenesis (GO:0072078)3.59066359
100protein depolymerization (GO:0051261)3.57062292
101regulation of mitotic spindle organization (GO:0060236)3.55595093
102fatty acid catabolic process (GO:0009062)3.54442400
103tricarboxylic acid cycle (GO:0006099)3.53938702
104alpha-amino acid catabolic process (GO:1901606)3.52624177
105cellular response to vitamin D (GO:0071305)3.52526741
106regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.51953377
107negative regulation of sterol transport (GO:0032372)3.51742528
108negative regulation of cholesterol transport (GO:0032375)3.51742528
109regulation of mesenchymal cell apoptotic process (GO:2001053)3.50903745
110kynurenine metabolic process (GO:0070189)3.50703272
111glutathione metabolic process (GO:0006749)3.50251848
112response to phenylpropanoid (GO:0080184)3.47689287
113sodium ion transport (GO:0006814)3.46645393
114glomerular epithelial cell development (GO:0072310)3.46466742
115indole-containing compound metabolic process (GO:0042430)3.45814718
116response to thyroid hormone (GO:0097066)3.44964289
117aromatic amino acid family metabolic process (GO:0009072)3.44835345
118sodium-independent organic anion transport (GO:0043252)3.44743380
119glutathione derivative biosynthetic process (GO:1901687)3.43967817
120glutathione derivative metabolic process (GO:1901685)3.43967817
121biotin metabolic process (GO:0006768)3.36419678
122hyperosmotic response (GO:0006972)3.34525778
123regulation of stem cell maintenance (GO:2000036)3.33849780
124organic acid catabolic process (GO:0016054)3.31667487
125carboxylic acid catabolic process (GO:0046395)3.31667487
126monocarboxylic acid catabolic process (GO:0072329)3.31052761
127ketone body metabolic process (GO:1902224)3.26894078
128dicarboxylic acid metabolic process (GO:0043648)3.26131900
129regulation of protein localization to cell surface (GO:2000008)3.25533487
130oxaloacetate metabolic process (GO:0006107)3.25349298
131regulation of catenin import into nucleus (GO:0035412)3.23341551
132bone remodeling (GO:0046849)3.21483481
133sulfur amino acid catabolic process (GO:0000098)3.20881021
134succinate metabolic process (GO:0006105)3.20766178
135regulation of spindle organization (GO:0090224)3.17600315
136regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.15699267
137regulation of potassium ion transmembrane transporter activity (GO:1901016)3.06608581
138cell differentiation involved in metanephros development (GO:0072202)3.04761927
139sister chromatid segregation (GO:0000819)3.04664934
140mitotic sister chromatid segregation (GO:0000070)2.95533048
141mesenchymal to epithelial transition (GO:0060231)2.92069084
142mesenchymal cell differentiation involved in renal system development (GO:2001012)2.89364998
143mesenchymal cell differentiation involved in kidney development (GO:0072161)2.89364998
144kidney epithelium development (GO:0072073)2.88333539
145microtubule depolymerization (GO:0007019)2.87753777
146regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.86155625
147positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.83308739
148negative regulation of kidney development (GO:0090185)2.81266365
149response to magnesium ion (GO:0032026)2.77962981
150glycine metabolic process (GO:0006544)2.73477053
151specification of organ identity (GO:0010092)2.72754711
152S-adenosylmethionine metabolic process (GO:0046500)2.71844701
153response to salt stress (GO:0009651)2.66890638
154cellular response to ammonium ion (GO:0071242)2.66114140
155DNA ligation (GO:0006266)2.64478018
156membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.64283878
157thyroid gland development (GO:0030878)2.60556027
158regulation of potassium ion transmembrane transport (GO:1901379)2.60495155
159renal system process (GO:0003014)2.60462229
160mammary gland alveolus development (GO:0060749)2.56621513
161* inorganic anion transport (GO:0015698)2.55416947
162ERK1 and ERK2 cascade (GO:0070371)2.54196061
163chromosome condensation (GO:0030261)2.51792231
164positive regulation of digestive system process (GO:0060456)2.49866483
165G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47625630
166kidney development (GO:0001822)2.44571465
167* chloride transmembrane transport (GO:1902476)2.42645326
168regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.40142488
169aminoglycoside antibiotic metabolic process (GO:0030647)10.7631201
170urate metabolic process (GO:0046415)10.4826503
171drug transmembrane transport (GO:0006855)10.1665693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.39740326
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.25290250
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.11908899
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.59174234
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.32376704
6ESR1_21235772_ChIP-Seq_MCF-7_Human4.10495368
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.71242435
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.64228271
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.61087444
10SALL1_21062744_ChIP-ChIP_HESCs_Human3.41866916
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.23266952
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.11578086
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.94389306
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.94017837
15AR_21909140_ChIP-Seq_LNCAP_Human2.88466754
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.86277852
17ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.84574523
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82608545
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.64047698
20CLOCK_20551151_ChIP-Seq_293T_Human2.54442352
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.52476074
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.46159114
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45583309
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.30506864
25DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.29850384
26NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.24881755
27VDR_22108803_ChIP-Seq_LS180_Human2.19516656
28CDX2_20551321_ChIP-Seq_CACO-2_Human2.18464224
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.08442266
30EZH2_22144423_ChIP-Seq_EOC_Human1.97084951
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96974422
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.96104917
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90823335
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.84262036
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78875206
36SOX2_16153702_ChIP-ChIP_HESCs_Human1.74345666
37LXR_22292898_ChIP-Seq_THP-1_Human1.68857077
38GATA4_25053715_ChIP-Seq_YYC3_Human1.68185727
39NANOG_16153702_ChIP-ChIP_HESCs_Human1.64765357
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.63206467
41RACK7_27058665_Chip-Seq_MCF-7_Human1.53761341
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53676524
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53676524
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53264689
45* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.53204122
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53134453
47* HNF4A_19822575_ChIP-Seq_HepG2_Human1.51699294
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49609606
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48360314
50* PHF8_20622853_ChIP-Seq_HELA_Human1.48139139
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.44116077
52HTT_18923047_ChIP-ChIP_STHdh_Human1.43979404
53IRF1_19129219_ChIP-ChIP_H3396_Human1.41104614
54GATA6_25053715_ChIP-Seq_YYC3_Human1.38827051
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37414599
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.37262860
57* HNFA_21074721_ChIP-Seq_CACO-2_Human1.36944912
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36565361
59SOX9_26525672_Chip-Seq_HEART_Mouse1.36378160
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35640395
61* TBL1_22424771_ChIP-Seq_293T_Human1.33196784
62EGR1_19032775_ChIP-ChIP_M12_Human1.33134334
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32804470
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32367812
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28430554
66SMAD4_21799915_ChIP-Seq_A2780_Human1.28141552
67* NFYB_21822215_ChIP-Seq_K562_Human1.27502774
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.26610204
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.25135089
70TBX20_22328084_ChIP-Seq_HEART_Mouse1.25135089
71NANOG_18692474_ChIP-Seq_MEFs_Mouse1.23206685
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23085342
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22003333
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.21365008
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20753951
76* FOXO3_23340844_ChIP-Seq_DLD1_Human1.20644799
77FUS_26573619_Chip-Seq_HEK293_Human1.20017292
78* NFYA_21822215_ChIP-Seq_K562_Human1.18594306
79TAF15_26573619_Chip-Seq_HEK293_Human1.18222664
80SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16291513
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.15725948
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15663575
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.14356597
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14223927
85TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14029448
86TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13576013
87* ETV1_20927104_ChIP-Seq_GIST48_Human1.13104005
88* RBPJ_21746931_ChIP-Seq_IB4_Human1.12234297
89PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12194360
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09746760
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.09724945
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08955976
93RXR_22108803_ChIP-Seq_LS180_Human1.08292617
94* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08024863
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07837058
96SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07436197
97SOX2_22085726_ChIP-Seq_NPCs_Mouse1.07386768
98CBP_21632823_ChIP-Seq_H3396_Human1.07281890
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.06078733
100SOX2_19829295_ChIP-Seq_ESCs_Human1.05367841
101NANOG_19829295_ChIP-Seq_ESCs_Human1.05367841
102P300_19829295_ChIP-Seq_ESCs_Human1.05006340
103* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.04842509
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04837875
105TCF4_22108803_ChIP-Seq_LS180_Human1.03333836
106POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03047107
107* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.01727536
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01674354
109GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01445852
110ZNF263_19887448_ChIP-Seq_K562_Human1.00470176
111CBX2_27304074_Chip-Seq_ESCs_Mouse0.99807282
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99545506
113GBX2_23144817_ChIP-Seq_PC3_Human0.98060473
114* GATA6_21074721_ChIP-Seq_CACO-2_Human0.96750424
115EZH2_27294783_Chip-Seq_ESCs_Mouse0.96320086
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96308822
117WT1_19549856_ChIP-ChIP_CCG9911_Human0.95971756
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95822315
119HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95667042
120KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95343183
121KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95343183
122KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95343183
123TP63_19390658_ChIP-ChIP_HaCaT_Human0.95167062
124* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94214842
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94034165
126SOX2_20726797_ChIP-Seq_SW620_Human0.93350988
127FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92701613
128AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92121839
129EP300_21415370_ChIP-Seq_HL-1_Mouse0.92096880
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92003180
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91902007
132SMAD3_21741376_ChIP-Seq_EPCs_Human0.91658166
133RAC3_21632823_ChIP-Seq_H3396_Human0.91488315
134EWS_26573619_Chip-Seq_HEK293_Human0.91232480
135* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90927662
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89156211
137CBP_20019798_ChIP-Seq_JUKART_Human0.89156211
138POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88939144
139ATF3_27146783_Chip-Seq_COLON_Human0.88258868
140HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87774120
141NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87682138
142PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87518943
143SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86972708
144* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86361166
145CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85668436
146BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.85369456
147SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84956216
148SOX11_22085726_ChIP-Seq_ESNs_Mouse0.84870940
149WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84503117
150SALL4_22934838_ChIP-ChIP_CD34+_Human0.84041688
151CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83328299
152PIAS1_25552417_ChIP-Seq_VCAP_Human0.83293451
153CREB1_26743006_Chip-Seq_LNCaP_Human0.82850199
154SMC4_20622854_ChIP-Seq_HELA_Human0.82360598
155THAP11_20581084_ChIP-Seq_MESCs_Mouse0.81947190
156NANOG_18555785_Chip-Seq_ESCs_Mouse0.81810756
157TET1_21451524_ChIP-Seq_MESCs_Mouse0.81716428
158PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80684177
159CSB_26484114_Chip-Seq_FIBROBLAST_Human0.80642796
160IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.79721656
161NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.79365888
162E2F1_17053090_ChIP-ChIP_MCF-7_Human0.79254228
163RING1B_27294783_Chip-Seq_NPCs_Mouse0.79119851
164TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.78819344
165* CTCF_27219007_Chip-Seq_Bcells_Human0.78787529
166ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78182580
167P300_27058665_Chip-Seq_ZR-75-30cells_Human0.77472510
168NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77280820
169TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77173778
170NFIB_24661679_ChIP-Seq_LUNG_Mouse0.77168045
171RNF2_27304074_Chip-Seq_NSC_Mouse0.77019506
172OCT4_20526341_ChIP-Seq_ESCs_Human0.76987835
173OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76848335
174JARID2_20064375_ChIP-Seq_MESCs_Mouse0.76714307
175POU3F2_20337985_ChIP-ChIP_501MEL_Human0.75954983
176FOXM1_26456572_ChIP-Seq_MCF-7_Human0.75723920
177* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75291968
178CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75289377
179MYC_19915707_ChIP-ChIP_AK7_Human0.74923549
180* P68_20966046_ChIP-Seq_HELA_Human0.73133512
181TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.72617743
182* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.72551081
183TP63_22573176_ChIP-Seq_HFKS_Human0.72138554
184EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.71755191
185SMAD4_21741376_ChIP-Seq_HESCs_Human0.71648362
186NANOG_16518401_ChIP-PET_MESCs_Mouse0.71236292
187P63_26484246_Chip-Seq_KERATINOCYTES_Human0.70771175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.26580782
2MP0004043_abnormal_pH_regulation7.15702716
3MP0004019_abnormal_vitamin_homeostasis5.02605041
4MP0005332_abnormal_amino_acid4.88061369
5MP0003195_calcinosis4.72014198
6MP0009643_abnormal_urine_homeostasis4.14792046
7MP0001765_abnormal_ion_homeostasis4.13421942
8MP0002139_abnormal_hepatobiliary_system3.90462124
9MP0002138_abnormal_hepatobiliary_system3.63516249
10MP0001756_abnormal_urination3.52464827
11MP0005636_abnormal_mineral_homeostasis3.28926696
12MP0002136_abnormal_kidney_physiology3.19383307
13MP0003878_abnormal_ear_physiology3.12612747
14MP0005377_hearing/vestibular/ear_phenot3.12612747
15MP0001958_emphysema2.68711325
16MP0008875_abnormal_xenobiotic_pharmacok2.52398348
17MP0003252_abnormal_bile_duct2.29309848
18MP0005365_abnormal_bile_salt2.06455142
19MP0008961_abnormal_basal_metabolism2.02721844
20MP0005058_abnormal_lysosome_morphology1.93282713
21MP0004885_abnormal_endolymph1.82033388
22MP0003186_abnormal_redox_activity1.76919538
23MP0005085_abnormal_gallbladder_physiolo1.73209970
24MP0001270_distended_abdomen1.70200050
25MP0000538_abnormal_urinary_bladder1.59512703
26MP0005451_abnormal_body_composition1.57226797
27MP0010030_abnormal_orbit_morphology1.53416581
28MP0005584_abnormal_enzyme/coenzyme_acti1.52927743
29MP0002168_other_aberrant_phenotype1.44516344
30MP0000230_abnormal_systemic_arterial1.40997231
31MP0003300_gastrointestinal_ulcer1.36929758
32MP0003806_abnormal_nucleotide_metabolis1.30782589
33MP0005319_abnormal_enzyme/_coenzyme1.29171330
34MP0006036_abnormal_mitochondrial_physio1.26894320
35MP0002837_dystrophic_cardiac_calcinosis1.26197317
36MP0002135_abnormal_kidney_morphology1.24740363
37MP0004215_abnormal_myocardial_fiber1.21873131
38MP0005670_abnormal_white_adipose1.21520520
39MP0002928_abnormal_bile_duct1.14561625
40MP0003938_abnormal_ear_development1.12620422
41MP0003137_abnormal_impulse_conducting1.10637258
42MP0005084_abnormal_gallbladder_morpholo1.09587751
43MP0003693_abnormal_embryo_hatching1.07282593
44MP0002653_abnormal_ependyma_morphology1.05329615
45MP0002876_abnormal_thyroid_physiology1.05066814
46MP0002896_abnormal_bone_mineralization1.03286622
47MP0005666_abnormal_adipose_tissue1.02389861
48MP0003283_abnormal_digestive_organ1.00360294
49MP0001293_anophthalmia0.98347696
50MP0000566_synostosis0.98089258
51MP0000049_abnormal_middle_ear0.94684597
52MP0005535_abnormal_body_temperature0.94099779
53MP0009672_abnormal_birth_weight0.93632685
54MP0001764_abnormal_homeostasis0.93420892
55MP0003646_muscle_fatigue0.89403393
56MP0002233_abnormal_nose_morphology0.87850235
57MP0004264_abnormal_extraembryonic_tissu0.85505047
58MP0004147_increased_porphyrin_level0.84163717
59MP0002234_abnormal_pharynx_morphology0.82130010
60MP0002089_abnormal_postnatal_growth/wei0.81318525
61MP0002132_abnormal_respiratory_system0.80420944
62MP0005395_other_phenotype0.80220039
63MP0002282_abnormal_trachea_morphology0.80173885
64MP0005367_renal/urinary_system_phenotyp0.79656636
65MP0000516_abnormal_urinary_system0.79656636
66MP0003638_abnormal_response/metabolism_0.78552644
67MP0003942_abnormal_urinary_system0.77859540
68MP0010234_abnormal_vibrissa_follicle0.77435733
69MP0002118_abnormal_lipid_homeostasis0.77131208
70MP0006054_spinal_hemorrhage0.76820069
71MP0001661_extended_life_span0.76736761
72MP0000747_muscle_weakness0.75995480
73MP0002163_abnormal_gland_morphology0.75099609
74MP0003191_abnormal_cellular_cholesterol0.72528059
75MP0005410_abnormal_fertilization0.72354263
76MP0001666_abnormal_nutrient_absorption0.72223758
77MP0009642_abnormal_blood_homeostasis0.72191487
78MP0003111_abnormal_nucleus_morphology0.71837238
79MP0000026_abnormal_inner_ear0.71002483
80MP0009703_decreased_birth_body0.68362929
81MP0000631_abnormal_neuroendocrine_gland0.68296740
82MP0001963_abnormal_hearing_physiology0.66831412
83MP0002249_abnormal_larynx_morphology0.66381940
84MP0003172_abnormal_lysosome_physiology0.65284831
85MP0002796_impaired_skin_barrier0.65033550
86MP0000681_abnormal_thyroid_gland0.62619572
87MP0002938_white_spotting0.61539280
88MP0003718_maternal_effect0.61530034
89MP0003698_abnormal_male_reproductive0.61486463
90MP0004272_abnormal_basement_membrane0.61050546
91MP0009764_decreased_sensitivity_to0.60807744
92MP0005165_increased_susceptibility_to0.60442642
93MP0002697_abnormal_eye_size0.59598838
94MP0001485_abnormal_pinna_reflex0.57808881
95MP0004036_abnormal_muscle_relaxation0.57662561
96MP0005220_abnormal_exocrine_pancreas0.57562764
97MP0001929_abnormal_gametogenesis0.57469460
98MP0004484_altered_response_of0.56368401
99MP0003959_abnormal_lean_body0.55277893
100MP0003937_abnormal_limbs/digits/tail_de0.54823622
101MP0000678_abnormal_parathyroid_gland0.54689179
102MP0003567_abnormal_fetal_cardiomyocyte0.54673115
103MP0003077_abnormal_cell_cycle0.53332195
104MP0005379_endocrine/exocrine_gland_phen0.53214862
105MP0000371_diluted_coat_color0.52960867
106MP0000534_abnormal_ureter_morphology0.52803655
107MP0000609_abnormal_liver_physiology0.51240345
108MP0005501_abnormal_skin_physiology0.51103616
109MP0010386_abnormal_urinary_bladder0.50950813
110MP0003221_abnormal_cardiomyocyte_apopto0.48465280
111MP0006035_abnormal_mitochondrial_morpho0.47620999
112MP0003119_abnormal_digestive_system0.47243991
113MP0003943_abnormal_hepatobiliary_system0.47218135
114MP0002115_abnormal_skeleton_extremities0.47055026
115MP0000598_abnormal_liver_morphology0.46846832
116MP0010329_abnormal_lipoprotein_level0.46816196
117MP0004858_abnormal_nervous_system0.46583254
118MP0006292_abnormal_olfactory_placode0.46575759
119MP0005248_abnormal_Harderian_gland0.46053351
120MP0004085_abnormal_heartbeat0.45632023
121MP0001145_abnormal_male_reproductive0.45176094
122MP0008469_abnormal_protein_level0.45042521
123MP0003795_abnormal_bone_structure0.44429434
124MP0005375_adipose_tissue_phenotype0.44235194
125MP0001286_abnormal_eye_development0.44087629
126MP0005391_vision/eye_phenotype0.43782622
127MP0003315_abnormal_perineum_morphology0.43653002
128MP0002998_abnormal_bone_remodeling0.42542990
129MP0002092_abnormal_eye_morphology0.42514606
130MP0005408_hypopigmentation0.42287354
131MP0002210_abnormal_sex_determination0.41966124
132MP0004742_abnormal_vestibular_system0.41961057
133MP0003329_amyloid_beta_deposits0.41574724
134MP0003011_delayed_dark_adaptation0.40565800
135MP0003953_abnormal_hormone_level0.40388797
136MP0003879_abnormal_hair_cell0.40382584
137MP0002161_abnormal_fertility/fecundity0.40374553
138MP0002127_abnormal_cardiovascular_syste0.39769272
139MP0008932_abnormal_embryonic_tissue0.38481057
140MP0002069_abnormal_eating/drinking_beha0.37693247
141MP0002078_abnormal_glucose_homeostasis0.37135916
142MP0002098_abnormal_vibrissa_morphology0.36883587
143MP0004233_abnormal_muscle_weight0.35800952
144MP0005167_abnormal_blood-brain_barrier0.35487447
145MP0004084_abnormal_cardiac_muscle0.35213420
146MP0008775_abnormal_heart_ventricle0.34930468
147MP0001663_abnormal_digestive_system0.34443203
148MP0000163_abnormal_cartilage_morphology0.33875246
149MP0008872_abnormal_physiological_respon0.33227027
150MP0005330_cardiomyopathy0.32021007
151MP0002972_abnormal_cardiac_muscle0.31751243
152MP0005620_abnormal_muscle_contractility0.31678349
153MP0001727_abnormal_embryo_implantation0.30853372

Predicted human phenotypes

RankGene SetZ-score
1Hypomagnesemia (HP:0002917)8.25608425
2* Increased circulating renin level (HP:0000848)7.59703782
3* Hypokalemic alkalosis (HP:0001949)7.45862458
4Abnormality of magnesium homeostasis (HP:0004921)7.02392200
5Gout (HP:0001997)7.01175176
6* Polyuria (HP:0000103)6.83833923
7* Metabolic alkalosis (HP:0200114)6.57864117
8* Abnormal urine output (HP:0012590)6.36611927
9Abnormal drinking behavior (HP:0030082)6.32079105
10Polydipsia (HP:0001959)6.32079105
11Tetany (HP:0001281)6.06067265
12* Abnormality of renal excretion (HP:0011036)6.01911347
13* Abnormality of chloride homeostasis (HP:0011422)5.90561895
14* Hyperactive renin-angiotensin system (HP:0000841)5.60788039
15Proximal tubulopathy (HP:0000114)5.50318911
16Hyperuricemia (HP:0002149)5.06289732
17Increased purine levels (HP:0004368)5.06289732
18Hyperglycinuria (HP:0003108)4.72190697
19* Abnormality of renin-angiotensin system (HP:0000847)4.69660562
20* Alkalosis (HP:0001948)4.67993367
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.59310294
22Abnormality of purine metabolism (HP:0004352)4.33072914
23Hypercalciuria (HP:0002150)4.31669287
24* Renal salt wasting (HP:0000127)4.30710152
25* Hyperaldosteronism (HP:0000859)4.17154432
26Generalized aminoaciduria (HP:0002909)4.05621808
27Abnormality of serine family amino acid metabolism (HP:0010894)3.83532450
28Abnormality of glycine metabolism (HP:0010895)3.83532450
29Renal tubular acidosis (HP:0001947)3.68532594
30* Hypokalemia (HP:0002900)3.65310860
31Abnormality of urine glucose concentration (HP:0011016)3.56001513
32Glycosuria (HP:0003076)3.56001513
33Ketoacidosis (HP:0001993)3.50002706
34Abnormality of nucleobase metabolism (HP:0010932)3.18969069
35Hyperphosphaturia (HP:0003109)3.16547052
36Delayed epiphyseal ossification (HP:0002663)3.16352832
37Nephrocalcinosis (HP:0000121)3.15006978
38* Abnormality of potassium homeostasis (HP:0011042)3.13342498
39Hydroxyprolinuria (HP:0003080)3.07465357
40Abnormality of proline metabolism (HP:0010907)3.07465357
41Ketosis (HP:0001946)3.02028100
42Abnormal urine phosphate concentration (HP:0012599)3.00943605
43Abnormality of fatty-acid metabolism (HP:0004359)2.93352553
44Large eyes (HP:0001090)2.80141039
45Nephrolithiasis (HP:0000787)2.76264423
46Metaphyseal cupping (HP:0003021)2.68948575
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.64642662
48Hyperglycinemia (HP:0002154)2.63228729
49Hypophosphatemia (HP:0002148)2.62788976
50Vascular calcification (HP:0004934)2.59580952
51Chondrocalcinosis (HP:0000934)2.58192470
52Rickets (HP:0002748)2.55392336
53Widely patent fontanelles and sutures (HP:0004492)2.53302515
54Abnormality of Sharpey fibers (HP:0100685)2.42381924
55Delayed CNS myelination (HP:0002188)2.39580679
56Hyperammonemia (HP:0001987)2.35690838
57Vacuolated lymphocytes (HP:0001922)2.34600508
58Cardiovascular calcification (HP:0011915)2.31140135
59Tubular atrophy (HP:0000092)2.30865010
60Vomiting (HP:0002013)2.30548823
61Dicarboxylic aciduria (HP:0003215)2.27258796
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27258796
63Enlarged kidneys (HP:0000105)2.26660329
64* Dehydration (HP:0001944)2.25382725
65Renal tubular dysfunction (HP:0000124)2.25136322
66Metabolic acidosis (HP:0001942)2.16914915
67Tubulointerstitial fibrosis (HP:0005576)2.15528120
68* Generalized muscle weakness (HP:0003324)2.15359219
69Thin bony cortex (HP:0002753)2.15230435
70Confusion (HP:0001289)2.12556459
71Potter facies (HP:0002009)2.11036747
72Facial shape deformation (HP:0011334)2.11036747
73Bilateral sensorineural hearing impairment (HP:0008619)2.10739540
74Abnormal enzyme/coenzyme activity (HP:0012379)2.09831671
75Malnutrition (HP:0004395)2.06403421
76Abnormality of alkaline phosphatase activity (HP:0004379)2.04685489
77Decreased circulating renin level (HP:0003351)2.04575384
78Glomerulosclerosis (HP:0000096)2.03429116
79Abnormality of sulfur amino acid metabolism (HP:0004339)1.99041086
80Lethargy (HP:0001254)1.98387040
81Abnormality of the costochondral junction (HP:0000919)1.95916582
82Lymphangioma (HP:0100764)1.92605796
83Abnormal tarsal ossification (HP:0008369)1.91923367
84* Abnormality of sodium homeostasis (HP:0010931)1.91544672
85Bicornuate uterus (HP:0000813)1.90642083
86Methylmalonic aciduria (HP:0012120)1.90228171
87Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87118072
88Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84315248
89Nausea (HP:0002018)1.84162869
90* Hypotension (HP:0002615)1.82651020
91Abnormality of the renal medulla (HP:0100957)1.80144597
92* Adrenal overactivity (HP:0002717)1.78469357
93Hyperkalemia (HP:0002153)1.78402762
94Irritability (HP:0000737)1.72454076
95Metaphyseal irregularity (HP:0003025)1.69837505
96Metaphyseal dysplasia (HP:0100255)1.65558334
97Axonal loss (HP:0003447)1.65547955
98* Hyponatremia (HP:0002902)1.64017336
99Elevated alkaline phosphatase (HP:0003155)1.63025423
100Nephrogenic diabetes insipidus (HP:0009806)1.62310834
101Abnormality of serum amino acid levels (HP:0003112)1.60982766
102Tachypnea (HP:0002789)1.59024696
103Neonatal onset (HP:0003623)1.56801941
104Focal segmental glomerulosclerosis (HP:0000097)1.52767314
105Paralysis (HP:0003470)1.52038499
106Intellectual disability, moderate (HP:0002342)1.43822930
107Pancreatic cysts (HP:0001737)1.37131892
108Abnormality of cochlea (HP:0000375)1.32882428
109High anterior hairline (HP:0009890)1.28971705
110Thyroid-stimulating hormone excess (HP:0002925)1.26616243
111Cystic liver disease (HP:0006706)1.24552170
112* Premature birth (HP:0001622)1.23279325
113Abnormal platelet function (HP:0011869)1.15950103
114Impaired platelet aggregation (HP:0003540)1.15950103
115Osteopenia (HP:0000938)1.15513973
116Small for gestational age (HP:0001518)1.14727097
117Hypothermia (HP:0002045)1.13027628
118Tubulointerstitial abnormality (HP:0001969)1.08664075
119Neonatal death (HP:0003811)1.06230193
120* Polyhydramnios (HP:0001561)1.01126169
121Occipital encephalocele (HP:0002085)1.01073147
122Abnormality of the renal cortex (HP:0011035)1.00356273
123Abnormality of calcium-phosphate metabolism (HP:0100530)0.97403331
124Respiratory insufficiency due to defective ciliary clearance (HP:0200073)0.97251745
125Morphological abnormality of the inner ear (HP:0011390)0.94860682
126Abnormality of macular pigmentation (HP:0008002)0.91474306
127Renal dysplasia (HP:0000110)0.90508051
128Flared metaphyses (HP:0003015)0.89029653
129Abnormal ciliary motility (HP:0012262)0.86474875
130Broad distal phalanx of finger (HP:0009836)0.85920845
131Paresthesia (HP:0003401)0.85512545
132Abnormal foot bone ossification (HP:0010675)0.84908856
133Osteomalacia (HP:0002749)0.82651741
134Abnormal respiratory motile cilium physiology (HP:0012261)0.82023705
13511 pairs of ribs (HP:0000878)0.81421434
136Goiter (HP:0000853)0.80404501

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK49.93624811
2OXSR18.05530119
3WNK37.44718748
4STK395.67196919
5BCKDK2.31221959
6BUB12.14501990
7STK38L2.07420575
8NEK11.77403775
9WNK11.76571775
10PDK31.66524117
11PDK41.66524117
12SGK2231.59365636
13SGK4941.59365636
14PDK21.36628275
15STK381.01866446
16TNIK0.99768302
17MST40.97433786
18TAF10.94630335
19TIE10.92232425
20LMTK20.90870636
21SGK20.89427799
22NEK20.88224962
23BRSK20.87554012
24SGK30.84388693
25PLK40.81401419
26MST1R0.78622346
27LRRK20.76214831
28BRD40.73305566
29TGFBR20.70245179
30FGFR40.64925550
31PINK10.63235478
32GSK3A0.61959256
33EPHB10.57938781
34MAP3K30.57670463
35PAK40.57093972
36NLK0.56628635
37BRSK10.55512037
38DMPK0.53550330
39FGFR20.53148142
40PLK30.53083151
41PBK0.52879327
42GRK60.50535323
43CDK190.47731522
44PLK10.47333893
45WEE10.47329643
46SGK10.46706175
47PTK20.41795715
48MAP3K70.40985811
49ABL20.40470344
50MELK0.39729722
51EPHA20.39701899
52MYLK0.39550225
53UHMK10.39471992
54CASK0.39255468
55PASK0.39218225
56CDK80.39049947
57PRKAA10.38489059
58MAP3K100.37794748
59NUAK10.37416621
60AURKB0.36733555
61DYRK1B0.35325037
62KDR0.33643873
63PRKCI0.33406656
64ERN10.32700131
65ADRBK20.31788661
66PDPK10.31071359
67STK30.30464507
68TRIB30.29905496
69STK100.29607046
70FER0.29270097
71PTK60.27706689
72TESK10.27686091
73ZAK0.27581115
74MET0.27522411
75MAPK110.26943811
76NME20.25900749
77INSRR0.24657835
78PAK30.24317427
79DDR20.23476299
80PRKAA20.21778136
81TSSK60.21348269
82PRKD20.20595045
83BRAF0.20349246
84CCNB10.19131173
85EPHA40.18443248
86LATS10.18343565
87PTK2B0.17980872
88LATS20.17921604
89FGFR10.17809244
90PRKCZ0.17778709
91NTRK10.17250148
92MAPK100.17233656
93MAP2K30.16914497
94FLT30.16750892
95STK40.16618683
96PDK10.16306255
97SCYL20.16137746
98CLK10.15560387
99RIPK10.15178809
100TGFBR10.14803216
101BMPR1B0.14328045
102PRKCD0.13827738
103AKT20.13627042
104STK160.13408783
105MAP3K110.13323828
106STK110.12991165
107PLK20.12907880
108CDK10.12483673
109AURKA0.11977351
110ERBB20.11811122
111MAPK150.11511001
112FRK0.11296340
113PRKACG0.11203169
114PIM10.11074002
115EPHB20.10537049
116AKT30.10508569
117PNCK0.09041845
118PAK10.07478278
119PRKCA0.06587942
120PRKACA0.06478458
121ROCK10.06201887
122MAP3K20.06123139
123PRKG10.05976322
124CDK20.05341249
125SRPK10.05193404
126TTK0.05148147
127BMX0.04928324
128MAPK120.04806559
129CHEK20.04750284
130MTOR0.04212425
131ATM0.04093094
132PRKCH0.03803003
133PRKCB0.02904092
134ERBB40.02841670
135GSK3B0.02697378
136CHEK10.02576824
137NME10.01873672
138IRAK20.00855140
139CSNK1A10.00305247
140INSR0.00056750
141JAK2-3.0382571
142PRKCG-0.0525328
143CSK-0.0511919
144IGF1R-0.0505569
145PRKACB-0.0453701
146MINK1-0.0414373
147CSNK1E-0.0412406
148ROCK2-0.0377212
149IRAK3-0.0294364
150PDGFRA-0.0191044
151MARK3-0.0188432
152MAP3K14-0.0185770
153SRC-0.0185293
154MAP2K2-0.0184668
155MAP3K8-0.0153968
156TAOK1-0.0014656

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.69536148
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.64553959
3Butanoate metabolism_Homo sapiens_hsa006503.50681517
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.39766805
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.29140878
6Propanoate metabolism_Homo sapiens_hsa006403.24917099
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.22859534
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.09584591
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.02563125
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.81750673
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.79405361
12Fatty acid degradation_Homo sapiens_hsa000712.39989396
13Pyruvate metabolism_Homo sapiens_hsa006202.36982309
14Peroxisome_Homo sapiens_hsa041462.35420079
15Vitamin digestion and absorption_Homo sapiens_hsa049772.22784034
16Tryptophan metabolism_Homo sapiens_hsa003802.12326238
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.10709825
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98169525
19beta-Alanine metabolism_Homo sapiens_hsa004101.87801058
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84444800
21Carbon metabolism_Homo sapiens_hsa012001.84095224
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74223626
23Fatty acid metabolism_Homo sapiens_hsa012121.72623274
24Glutathione metabolism_Homo sapiens_hsa004801.71467565
25Bile secretion_Homo sapiens_hsa049761.68784246
26* Collecting duct acid secretion_Homo sapiens_hsa049661.53551482
27Sulfur metabolism_Homo sapiens_hsa009201.53449092
28Mineral absorption_Homo sapiens_hsa049781.47077825
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44918856
30Arginine and proline metabolism_Homo sapiens_hsa003301.40297522
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40223773
32Protein digestion and absorption_Homo sapiens_hsa049741.37867651
33Other glycan degradation_Homo sapiens_hsa005111.33764210
34Lysine degradation_Homo sapiens_hsa003101.30588411
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25003125
36PPAR signaling pathway_Homo sapiens_hsa033201.20064865
37Arginine biosynthesis_Homo sapiens_hsa002201.14295926
38Biosynthesis of amino acids_Homo sapiens_hsa012301.12512713
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11474539
40Folate biosynthesis_Homo sapiens_hsa007901.10961428
41Nitrogen metabolism_Homo sapiens_hsa009101.05319093
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04414919
43Renin-angiotensin system_Homo sapiens_hsa046141.01404705
44Starch and sucrose metabolism_Homo sapiens_hsa005000.99846408
45Selenocompound metabolism_Homo sapiens_hsa004500.99748789
46Basal cell carcinoma_Homo sapiens_hsa052170.98251191
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97160925
48Fructose and mannose metabolism_Homo sapiens_hsa000510.95654891
49Phenylalanine metabolism_Homo sapiens_hsa003600.94902781
50Oxidative phosphorylation_Homo sapiens_hsa001900.90305245
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86768039
52Glycerolipid metabolism_Homo sapiens_hsa005610.86052214
53Histidine metabolism_Homo sapiens_hsa003400.84616060
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.83872286
55Thyroid cancer_Homo sapiens_hsa052160.83499074
56TGF-beta signaling pathway_Homo sapiens_hsa043500.83211523
57Mismatch repair_Homo sapiens_hsa034300.78878827
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.74998733
59Hippo signaling pathway_Homo sapiens_hsa043900.74018951
60Pentose phosphate pathway_Homo sapiens_hsa000300.71207250
61Endometrial cancer_Homo sapiens_hsa052130.70901463
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68706208
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68261941
64Fatty acid elongation_Homo sapiens_hsa000620.67834478
65Lysosome_Homo sapiens_hsa041420.67294143
66Fanconi anemia pathway_Homo sapiens_hsa034600.66915478
67mRNA surveillance pathway_Homo sapiens_hsa030150.66451151
68Melanoma_Homo sapiens_hsa052180.65293176
69Thyroid hormone synthesis_Homo sapiens_hsa049180.64624832
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64053593
71Adherens junction_Homo sapiens_hsa045200.63051133
72Metabolic pathways_Homo sapiens_hsa011000.54611093
73Gastric acid secretion_Homo sapiens_hsa049710.54221467
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53268819
75Chemical carcinogenesis_Homo sapiens_hsa052040.52493387
76RNA transport_Homo sapiens_hsa030130.51702284
77Parkinsons disease_Homo sapiens_hsa050120.51329615
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.49496846
79Cell cycle_Homo sapiens_hsa041100.49335604
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47796420
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.47649775
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.46591921
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46448049
84Basal transcription factors_Homo sapiens_hsa030220.45755843
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44593322
86FoxO signaling pathway_Homo sapiens_hsa040680.42971182
87Dilated cardiomyopathy_Homo sapiens_hsa054140.42901711
88Vibrio cholerae infection_Homo sapiens_hsa051100.41172993
89Olfactory transduction_Homo sapiens_hsa047400.39768350
90Homologous recombination_Homo sapiens_hsa034400.39454635
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.39165663
92Gap junction_Homo sapiens_hsa045400.37916604
93Oocyte meiosis_Homo sapiens_hsa041140.35471802
94Fatty acid biosynthesis_Homo sapiens_hsa000610.35206743
95Focal adhesion_Homo sapiens_hsa045100.33503275
96Arachidonic acid metabolism_Homo sapiens_hsa005900.32806748
97Nucleotide excision repair_Homo sapiens_hsa034200.31076523
98Retinol metabolism_Homo sapiens_hsa008300.30833942
99Prostate cancer_Homo sapiens_hsa052150.30482485
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27979856
101ABC transporters_Homo sapiens_hsa020100.27351129
102Cardiac muscle contraction_Homo sapiens_hsa042600.27189505
103Synaptic vesicle cycle_Homo sapiens_hsa047210.25337682
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24058129
105Tyrosine metabolism_Homo sapiens_hsa003500.23596661
106Steroid biosynthesis_Homo sapiens_hsa001000.23579385
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23000794
108Sulfur relay system_Homo sapiens_hsa041220.21006400
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19661107
110Choline metabolism in cancer_Homo sapiens_hsa052310.18477584
111Alzheimers disease_Homo sapiens_hsa050100.16889995
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.16442822
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15705680
114Sphingolipid metabolism_Homo sapiens_hsa006000.13159545
115Galactose metabolism_Homo sapiens_hsa000520.11202443
116Bladder cancer_Homo sapiens_hsa052190.10624979
117Huntingtons disease_Homo sapiens_hsa050160.10117152
118Insulin resistance_Homo sapiens_hsa049310.08991175
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.08608614
120Rheumatoid arthritis_Homo sapiens_hsa053230.05677488
121Inositol phosphate metabolism_Homo sapiens_hsa005620.04900238
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.03407456
123AMPK signaling pathway_Homo sapiens_hsa041520.02933857
124Hedgehog signaling pathway_Homo sapiens_hsa043400.01645820
125Tight junction_Homo sapiens_hsa045300.00325377
126One carbon pool by folate_Homo sapiens_hsa006700.00053613
127ECM-receptor interaction_Homo sapiens_hsa04512-0.0187080
128Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0036193

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