CLCP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.03852386
2negative regulation of translation, ncRNA-mediated (GO:0040033)5.03852386
3regulation of translation, ncRNA-mediated (GO:0045974)5.03852386
4cullin deneddylation (GO:0010388)4.44420767
5regulation of mesoderm development (GO:2000380)4.38827394
6regulation of timing of cell differentiation (GO:0048505)4.16085959
7protein deneddylation (GO:0000338)4.07430475
8DNA replication checkpoint (GO:0000076)4.06742207
9regulation of development, heterochronic (GO:0040034)4.01819136
10regulation of coenzyme metabolic process (GO:0051196)4.00482132
11regulation of cofactor metabolic process (GO:0051193)4.00482132
12anterior/posterior axis specification, embryo (GO:0008595)4.00228412
13somatic hypermutation of immunoglobulin genes (GO:0016446)3.90334309
14somatic diversification of immune receptors via somatic mutation (GO:0002566)3.90334309
15regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.89054131
16negative regulation of DNA recombination (GO:0045910)3.83191248
17regulation of helicase activity (GO:0051095)3.80782270
18nodal signaling pathway (GO:0038092)3.77364006
19regulation of telomere maintenance (GO:0032204)3.76899523
20mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.74732070
21intra-S DNA damage checkpoint (GO:0031573)3.73415584
22IMP biosynthetic process (GO:0006188)3.68998233
23response to pheromone (GO:0019236)3.64685805
24regulation of acyl-CoA biosynthetic process (GO:0050812)3.63217033
25presynaptic membrane assembly (GO:0097105)3.55594800
26purine nucleobase biosynthetic process (GO:0009113)3.50688162
27cell migration involved in gastrulation (GO:0042074)3.47358077
28DNA double-strand break processing (GO:0000729)3.45125693
29sequestering of extracellular ligand from receptor (GO:0035581)3.36636262
30regulation of collateral sprouting (GO:0048670)3.33084022
31peptidyl-histidine modification (GO:0018202)3.29541238
32lysine metabolic process (GO:0006553)3.28627449
33lysine catabolic process (GO:0006554)3.28627449
34negative regulation of DNA-dependent DNA replication (GO:2000104)3.24813260
35IMP metabolic process (GO:0046040)3.24055879
36L-serine metabolic process (GO:0006563)3.23785076
37histone exchange (GO:0043486)3.20644459
38ADP metabolic process (GO:0046031)3.15919899
39regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.11056780
40regulation of mitotic spindle checkpoint (GO:1903504)3.11056780
41S-adenosylmethionine metabolic process (GO:0046500)3.10580004
42chromatin remodeling at centromere (GO:0031055)3.09652860
43water-soluble vitamin biosynthetic process (GO:0042364)3.08955633
44mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.07351467
45positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.07351467
46DNA damage response, detection of DNA damage (GO:0042769)3.03692304
47ribosome assembly (GO:0042255)3.03365117
48nucleobase biosynthetic process (GO:0046112)3.03206435
49negative regulation of activin receptor signaling pathway (GO:0032926)2.98302821
50replication fork processing (GO:0031297)2.98288876
51regulation of sulfur metabolic process (GO:0042762)2.97731168
52telomere maintenance via telomerase (GO:0007004)2.94552071
53negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.93964124
54AMP metabolic process (GO:0046033)2.91708169
55negative regulation of dendrite development (GO:2000171)2.91689393
56mitotic G2/M transition checkpoint (GO:0044818)2.90859714
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90007700
58female gonad development (GO:0008585)2.88109757
59cell wall macromolecule catabolic process (GO:0016998)2.85000565
60regulation of nuclear cell cycle DNA replication (GO:0033262)2.84563340
61DNA ligation (GO:0006266)2.80587982
62presynaptic membrane organization (GO:0097090)2.76122242
63C4-dicarboxylate transport (GO:0015740)2.74526777
64positive regulation of cardiac muscle cell proliferation (GO:0060045)2.74400101
65establishment of integrated proviral latency (GO:0075713)2.72920045
66regulation of activin receptor signaling pathway (GO:0032925)2.72600693
67maturation of 5.8S rRNA (GO:0000460)2.72508227
68response to X-ray (GO:0010165)2.71779150
69regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.71121681
70pre-miRNA processing (GO:0031054)2.70556800
71CENP-A containing nucleosome assembly (GO:0034080)2.69654418
72nuclear pore organization (GO:0006999)2.68713581
73aspartate family amino acid catabolic process (GO:0009068)2.67343137
74intraciliary transport (GO:0042073)2.67126504
75positive regulation of mitochondrial fission (GO:0090141)2.66907830
76branched-chain amino acid catabolic process (GO:0009083)2.66814552
77regulation of telomere maintenance via telomerase (GO:0032210)2.65947578
78double-strand break repair via nonhomologous end joining (GO:0006303)2.63162510
79non-recombinational repair (GO:0000726)2.63162510
80peptidyl-cysteine modification (GO:0018198)2.61553723
81glyoxylate metabolic process (GO:0046487)2.59529412
82kidney morphogenesis (GO:0060993)2.57440030
83DNA strand renaturation (GO:0000733)2.55928063
84RNA-dependent DNA replication (GO:0006278)2.55426439
85forebrain neuron differentiation (GO:0021879)2.54941933
86cholesterol biosynthetic process (GO:0006695)2.54284112
87DNA replication-dependent nucleosome organization (GO:0034723)2.52994335
88DNA replication-dependent nucleosome assembly (GO:0006335)2.52994335
89regulation of keratinocyte proliferation (GO:0010837)2.51072440
90spindle checkpoint (GO:0031577)2.50566597
91negative regulation of mitotic sister chromatid separation (GO:2000816)2.49921344
92negative regulation of sister chromatid segregation (GO:0033046)2.49921344
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.49921344
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.49921344
95negative regulation of mitotic sister chromatid segregation (GO:0033048)2.49921344
96mitotic spindle checkpoint (GO:0071174)2.49906926
97histone H2A acetylation (GO:0043968)2.49290436
98L-ascorbic acid metabolic process (GO:0019852)2.48987345
99negative regulation of transcription regulatory region DNA binding (GO:2000678)2.47630676
100nuclear pore complex assembly (GO:0051292)2.47589383

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.03521771
2ZNF274_21170338_ChIP-Seq_K562_Hela3.65691687
3E2F7_22180533_ChIP-Seq_HELA_Human3.55978074
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.42783626
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.37878504
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.80259764
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77034581
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.72293640
9VDR_22108803_ChIP-Seq_LS180_Human2.57448140
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.51011429
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.35429026
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.34401818
13GBX2_23144817_ChIP-Seq_PC3_Human2.27747263
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.22480218
15P300_19829295_ChIP-Seq_ESCs_Human2.21313796
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18432369
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.17579197
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15932924
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13027453
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.10963580
21PCGF2_27294783_Chip-Seq_NPCs_Mouse2.02891236
22POU5F1_16153702_ChIP-ChIP_HESCs_Human1.97234631
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96314812
24FUS_26573619_Chip-Seq_HEK293_Human1.92180701
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.86742513
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.85472585
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80711537
28EWS_26573619_Chip-Seq_HEK293_Human1.70858787
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70422776
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67931069
31TAF15_26573619_Chip-Seq_HEK293_Human1.66604825
32ELK1_19687146_ChIP-ChIP_HELA_Human1.64358558
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64291017
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61367504
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61211880
36NANOG_16153702_ChIP-ChIP_HESCs_Human1.56782916
37GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.51489706
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.51420775
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.51420775
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.51420775
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51224685
42SOX2_16153702_ChIP-ChIP_HESCs_Human1.43941606
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41572120
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41033132
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40867691
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.39754195
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.39255175
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37644894
49MYC_18940864_ChIP-ChIP_HL60_Human1.33204256
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.32925736
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32029746
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31593279
53BCAT_22108803_ChIP-Seq_LS180_Human1.31374398
54KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29959857
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28594755
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27187918
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22773480
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21666107
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18235326
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.17947057
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17614290
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.17534598
63VDR_23849224_ChIP-Seq_CD4+_Human1.17470643
64CBP_20019798_ChIP-Seq_JUKART_Human1.17327687
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17327687
66SMAD4_21799915_ChIP-Seq_A2780_Human1.15060760
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12528027
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10778022
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10765700
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10451661
71TCF4_22108803_ChIP-Seq_LS180_Human1.10413692
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09264642
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08887811
74ER_23166858_ChIP-Seq_MCF-7_Human1.08460010
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.07859054
76SMAD4_21741376_ChIP-Seq_HESCs_Human1.06894333
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05363464
78SMAD3_21741376_ChIP-Seq_HESCs_Human1.02394700
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02212889
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02056077
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02019756
82AR_25329375_ChIP-Seq_VCAP_Human1.01559032
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.01270009
84IRF1_19129219_ChIP-ChIP_H3396_Human1.00727100
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00574594
86FOXP3_21729870_ChIP-Seq_TREG_Human0.99490615
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99452829
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99068069
89STAT3_23295773_ChIP-Seq_U87_Human0.96532772
90TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96518754
91RUNX2_22187159_ChIP-Seq_PCA_Human0.96043431
92TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94991399
93CRX_20693478_ChIP-Seq_RETINA_Mouse0.94041304
94P53_22387025_ChIP-Seq_ESCs_Mouse0.93337950
95SOX2_19829295_ChIP-Seq_ESCs_Human0.92989693
96NANOG_19829295_ChIP-Seq_ESCs_Human0.92989693
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92451976
98NANOG_18555785_Chip-Seq_ESCs_Mouse0.90500085
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89755258
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89157712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry4.18586284
2MP0008877_abnormal_DNA_methylation3.29248178
3MP0008058_abnormal_DNA_repair3.13927959
4MP0004133_heterotaxia2.71178251
5MP0003941_abnormal_skin_development2.68623548
6MP0010030_abnormal_orbit_morphology2.66262422
7MP0003136_yellow_coat_color2.60925179
8MP0003693_abnormal_embryo_hatching2.49546410
9MP0001188_hyperpigmentation2.45324479
10MP0006072_abnormal_retinal_apoptosis2.40814047
11MP0002736_abnormal_nociception_after2.25858711
12MP0001529_abnormal_vocalization2.25842986
13MP0003119_abnormal_digestive_system2.23771422
14MP0010094_abnormal_chromosome_stability2.13859679
15MP0003787_abnormal_imprinting2.08049616
16MP0003567_abnormal_fetal_cardiomyocyte2.05173858
17MP0002102_abnormal_ear_morphology2.03453505
18MP0008932_abnormal_embryonic_tissue2.01846421
19MP0002938_white_spotting1.99234238
20MP0006292_abnormal_olfactory_placode1.98701722
21MP0002254_reproductive_system_inflammat1.96889359
22MP0003111_abnormal_nucleus_morphology1.85455963
23MP0004147_increased_porphyrin_level1.80877025
24MP0000569_abnormal_digit_pigmentation1.78439572
25MP0001968_abnormal_touch/_nociception1.71897289
26MP0003718_maternal_effect1.63857307
27MP0005253_abnormal_eye_physiology1.62747689
28MP0001486_abnormal_startle_reflex1.61431800
29MP0008004_abnormal_stomach_pH1.59351214
30MP0003880_abnormal_central_pattern1.54994733
31MP0004215_abnormal_myocardial_fiber1.54469362
32MP0000749_muscle_degeneration1.52678921
33MP0008007_abnormal_cellular_replicative1.49538438
34MP0003121_genomic_imprinting1.46882086
35MP0005171_absent_coat_pigmentation1.42923314
36MP0001293_anophthalmia1.38358021
37MP0002638_abnormal_pupillary_reflex1.37903262
38MP0003806_abnormal_nucleotide_metabolis1.36156269
39MP0000372_irregular_coat_pigmentation1.35066401
40MP0003937_abnormal_limbs/digits/tail_de1.32484748
41MP0003077_abnormal_cell_cycle1.29572114
42MP0009703_decreased_birth_body1.28411997
43MP0002233_abnormal_nose_morphology1.24835886
44MP0009697_abnormal_copulation1.24397767
45MP0003137_abnormal_impulse_conducting1.21881567
46MP0000566_synostosis1.21779470
47MP0002837_dystrophic_cardiac_calcinosis1.18369426
48MP0002735_abnormal_chemical_nociception1.16317170
49MP0002184_abnormal_innervation1.15341333
50MP0004145_abnormal_muscle_electrophysio1.12787648
51MP0000516_abnormal_urinary_system1.12040174
52MP0005367_renal/urinary_system_phenotyp1.12040174
53MP0001764_abnormal_homeostasis1.11032449
54MP0001984_abnormal_olfaction1.10303892
55MP0004043_abnormal_pH_regulation1.08880825
56MP0001286_abnormal_eye_development1.07783126
57MP0009672_abnormal_birth_weight1.07719366
58MP0000778_abnormal_nervous_system1.06373859
59MP0002751_abnormal_autonomic_nervous1.06050361
60MP0004957_abnormal_blastocyst_morpholog1.04371641
61MP0005391_vision/eye_phenotype1.03709048
62MP0005330_cardiomyopathy1.02963733
63MP0006035_abnormal_mitochondrial_morpho0.98905404
64MP0001177_atelectasis0.96823967
65MP0005551_abnormal_eye_electrophysiolog0.94314432
66MP0005394_taste/olfaction_phenotype0.92127292
67MP0005499_abnormal_olfactory_system0.92127292
68MP0004084_abnormal_cardiac_muscle0.90839794
69MP0003385_abnormal_body_wall0.90521390
70MP0002090_abnormal_vision0.89678539
71MP0006036_abnormal_mitochondrial_physio0.89181787
72MP0000647_abnormal_sebaceous_gland0.89134424
73MP0000049_abnormal_middle_ear0.87966760
74MP0003122_maternal_imprinting0.86903265
75MP0005620_abnormal_muscle_contractility0.86509498
76MP0002752_abnormal_somatic_nervous0.86179295
77MP0001661_extended_life_span0.85707008
78MP0001929_abnormal_gametogenesis0.85165140
79MP0005187_abnormal_penis_morphology0.84422533
80MP0003315_abnormal_perineum_morphology0.81930054
81MP0002111_abnormal_tail_morphology0.81442935
82MP0004085_abnormal_heartbeat0.81147531
83MP0002734_abnormal_mechanical_nocicepti0.80604413
84MP0000026_abnormal_inner_ear0.79901764
85MP0008789_abnormal_olfactory_epithelium0.79851697
86MP0000358_abnormal_cell_content/0.78498184
87MP0010352_gastrointestinal_tract_polyps0.78386659
88MP0002272_abnormal_nervous_system0.77310893
89MP0006276_abnormal_autonomic_nervous0.74488795
90MP0000428_abnormal_craniofacial_morphol0.73950234
91MP0002163_abnormal_gland_morphology0.73626942
92MP0002084_abnormal_developmental_patter0.73421292
93MP0005248_abnormal_Harderian_gland0.73269222
94MP0000955_abnormal_spinal_cord0.73247234
95MP0003938_abnormal_ear_development0.72784725
96MP0003698_abnormal_male_reproductive0.72663227
97MP0002932_abnormal_joint_morphology0.72370403
98MP0008872_abnormal_physiological_respon0.72239355
99MP0005380_embryogenesis_phenotype0.71479848
100MP0001672_abnormal_embryogenesis/_devel0.71479848

Predicted human phenotypes

RankGene SetZ-score
1Oligodactyly (hands) (HP:0001180)5.35545573
2Intestinal atresia (HP:0011100)5.32011978
3Abnormality of the labia minora (HP:0012880)4.64289213
4Aqueductal stenosis (HP:0002410)4.30244686
5Esophageal atresia (HP:0002032)4.11515299
6Abnormality of the parathyroid morphology (HP:0011766)3.93921502
7Nuclear cataract (HP:0100018)3.91658812
8Congenital malformation of the right heart (HP:0011723)3.81836718
9Double outlet right ventricle (HP:0001719)3.81836718
10Oligodactyly (HP:0012165)3.76769585
11Progressive inability to walk (HP:0002505)3.76328806
12Absent radius (HP:0003974)3.36348142
13Labial hypoplasia (HP:0000066)3.31545573
14Aplasia involving forearm bones (HP:0009822)3.25713162
15Absent forearm bone (HP:0003953)3.25713162
16Ependymoma (HP:0002888)3.23926860
17Hypoplastic female external genitalia (HP:0012815)3.16016346
18Hepatoblastoma (HP:0002884)3.13817251
19Renal hypoplasia (HP:0000089)3.06667541
20Colon cancer (HP:0003003)3.05599284
21Gastrointestinal atresia (HP:0002589)3.05469917
22Carpal bone hypoplasia (HP:0001498)3.03466410
23Inability to walk (HP:0002540)2.91682303
24Chin dimple (HP:0010751)2.90186444
25Anal stenosis (HP:0002025)2.79051107
26Bifid tongue (HP:0010297)2.77731220
27Cupped ear (HP:0000378)2.74561831
28Abnormality of the ileum (HP:0001549)2.73685696
29Horseshoe kidney (HP:0000085)2.73635117
30Abnormality of the labia (HP:0000058)2.72219118
31Meckel diverticulum (HP:0002245)2.67049516
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.66418618
33Agnosia (HP:0010524)2.65953223
34Chromsome breakage (HP:0040012)2.58570289
35Abnormality of the astrocytes (HP:0100707)2.58188506
36Astrocytoma (HP:0009592)2.58188506
37Rhabdomyosarcoma (HP:0002859)2.55271693
38Hemivertebrae (HP:0002937)2.55221679
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49311396
40Gonadotropin excess (HP:0000837)2.48485578
41Down-sloping shoulders (HP:0200021)2.42617011
42Hyperglycinemia (HP:0002154)2.38827670
43Anencephaly (HP:0002323)2.36071092
44Abnormality of abdominal situs (HP:0011620)2.35192603
45Abdominal situs inversus (HP:0003363)2.35192603
46Medulloblastoma (HP:0002885)2.32554926
47Anophthalmia (HP:0000528)2.31460787
48Abnormality of chromosome stability (HP:0003220)2.30065222
49Glioma (HP:0009733)2.29845860
50Abnormality of glycine metabolism (HP:0010895)2.29643500
51Abnormality of serine family amino acid metabolism (HP:0010894)2.29643500
52Abolished electroretinogram (ERG) (HP:0000550)2.28515339
53Aplasia/Hypoplasia of the ulna (HP:0006495)2.27901605
54Dyschromatopsia (HP:0007641)2.26820682
55Hyperglycinuria (HP:0003108)2.25585165
56Septo-optic dysplasia (HP:0100842)2.22996240
57Stenosis of the external auditory canal (HP:0000402)2.21790753
58Triphalangeal thumb (HP:0001199)2.20629530
59Abnormal biliary tract physiology (HP:0012439)2.20271233
60Bile duct proliferation (HP:0001408)2.20271233
61Hypoplasia of the ulna (HP:0003022)2.16652634
62Pancreatic cysts (HP:0001737)2.16399903
63Exercise-induced muscle cramps (HP:0003710)2.15907763
64Deep palmar crease (HP:0006191)2.14222992
65Fibular aplasia (HP:0002990)2.10745375
66Abnormality of the duodenum (HP:0002246)2.08814064
67Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.07108410
68Preaxial hand polydactyly (HP:0001177)2.00021446
69Neoplasm of the oral cavity (HP:0100649)1.97953458
70Neoplasm of striated muscle (HP:0009728)1.95754039
71Anal atresia (HP:0002023)1.94390891
72Abnormality of the preputium (HP:0100587)1.94297586
73Molar tooth sign on MRI (HP:0002419)1.94123884
74Abnormality of midbrain morphology (HP:0002418)1.94123884
75Chorioretinal atrophy (HP:0000533)1.91970676
76Rimmed vacuoles (HP:0003805)1.89423182
77Bifid scrotum (HP:0000048)1.86377021
78Sensory axonal neuropathy (HP:0003390)1.84821727
79Growth hormone deficiency (HP:0000824)1.83691630
80Abnormality of serum amino acid levels (HP:0003112)1.82030107
81Myelomeningocele (HP:0002475)1.80904227
82Delayed puberty (HP:0000823)1.79614002
83Cleft eyelid (HP:0000625)1.79481516
84Abnormality of the shoulder girdle musculature (HP:0001435)1.78915058
85Abnormality of alanine metabolism (HP:0010916)1.77968340
86Hyperalaninemia (HP:0003348)1.77968340
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77968340
88Neoplasm of the adrenal gland (HP:0100631)1.77595219
89Cutaneous finger syndactyly (HP:0010554)1.76753762
90Shoulder girdle muscle weakness (HP:0003547)1.72942411
91Broad-based gait (HP:0002136)1.71383125
92Abnormality of the hip-girdle musculature (HP:0001445)1.70126173
93Abnormality of the musculature of the pelvis (HP:0001469)1.70126173
94Short thumb (HP:0009778)1.68994297
95Mixed hearing impairment (HP:0000410)1.68421653
96Synostosis of carpal bones (HP:0005048)1.67927476
97Dandy-Walker malformation (HP:0001305)1.67762428
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.64390001
99Overfolded helix (HP:0000396)1.61485463
100Poor suck (HP:0002033)1.60559422

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.60608132
2WNK35.02184458
3TRIM283.30895330
4ERBB43.21423098
5PBK2.82910066
6SRPK12.73850066
7FRK2.57945911
8TNIK2.49730663
9TSSK62.23575191
10INSRR2.15359266
11NUAK11.99756057
12EPHA41.96747550
13IRAK21.95239773
14OBSCN1.95197584
15PLK31.84938532
16ACVR1B1.81486912
17BMPR1B1.81427244
18NEK11.76933270
19BCR1.59619870
20BUB11.53001322
21IRAK11.51281052
22BCKDK1.41538017
23CDC71.40725868
24FGFR21.40258111
25CASK1.39322967
26MKNK21.37327060
27PLK41.37273881
28BRSK21.33114163
29WEE11.27389427
30MKNK11.18586092
31ZAK1.17925584
32TGFBR11.17591657
33CSNK1G11.17341689
34MAP4K21.13696117
35YES11.12906957
36MARK31.08948669
37PLK11.08516177
38PDK21.07839664
39GRK11.06089019
40DYRK21.03466054
41VRK11.01544074
42CSNK1G31.01049711
43MAPK131.00425453
44TTK0.98299595
45CSNK1A1L0.97167074
46CSNK1G20.93291083
47EIF2AK30.89859438
48PLK20.86817758
49BRSK10.84383308
50NME10.80421216
51TIE10.80194553
52CDK30.78026146
53NEK60.76241222
54MAP3K100.73080150
55MAP3K40.69186627
56ADRBK20.68366795
57PNCK0.66368335
58BRD40.64677222
59FLT30.62474726
60ATM0.60361704
61MST40.58173902
62PIK3CA0.58161269
63FGFR10.55082807
64ATR0.54434211
65PKN20.54105802
66DYRK1A0.53737516
67VRK20.53735368
68RPS6KA40.52790341
69NTRK20.51901621
70MUSK0.51041470
71MAP2K70.51037845
72STK390.50977131
73OXSR10.50242611
74NLK0.47474223
75LATS10.47281056
76WNK40.46905166
77PAK30.45616121
78TAOK10.45171815
79AURKB0.42600935
80DYRK30.42415011
81ROCK10.40992453
82CHEK20.40419124
83ROCK20.39212635
84CHEK10.37834512
85PRKDC0.36012199
86CAMK1G0.35625156
87PHKG10.34664344
88PHKG20.34664344
89PRKCE0.34400942
90PASK0.34334939
91SIK30.34070804
92PRKCG0.32618630
93EIF2AK20.32391839
94CSNK2A10.30757591
95MARK10.30496870
96CSNK1A10.30458918
97EIF2AK10.30249561
98STK38L0.28774061
99CDK10.28058497
100PRKCI0.24892414

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.07545023
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.95910029
3Steroid biosynthesis_Homo sapiens_hsa001002.94835387
4Propanoate metabolism_Homo sapiens_hsa006402.66642632
5Proteasome_Homo sapiens_hsa030502.46976355
6Mismatch repair_Homo sapiens_hsa034302.38196875
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36122278
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35284693
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11267928
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10513374
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06485049
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98931027
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97964897
14Cysteine and methionine metabolism_Homo sapiens_hsa002701.92113622
15Fanconi anemia pathway_Homo sapiens_hsa034601.89697233
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87986002
17Pyruvate metabolism_Homo sapiens_hsa006201.84793168
18DNA replication_Homo sapiens_hsa030301.82157859
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77040053
20RNA polymerase_Homo sapiens_hsa030201.73876269
21RNA transport_Homo sapiens_hsa030131.69968917
22Homologous recombination_Homo sapiens_hsa034401.67320389
23RNA degradation_Homo sapiens_hsa030181.66586332
24Biosynthesis of amino acids_Homo sapiens_hsa012301.57663825
25One carbon pool by folate_Homo sapiens_hsa006701.53235695
26Carbon metabolism_Homo sapiens_hsa012001.47597086
27Basal transcription factors_Homo sapiens_hsa030221.44772831
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44656506
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44598825
30Arginine and proline metabolism_Homo sapiens_hsa003301.39567276
31Butanoate metabolism_Homo sapiens_hsa006501.34264662
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.26580561
33Phototransduction_Homo sapiens_hsa047441.25320222
34Base excision repair_Homo sapiens_hsa034101.24655550
35Selenocompound metabolism_Homo sapiens_hsa004501.24290089
36Purine metabolism_Homo sapiens_hsa002301.11455288
37Fatty acid elongation_Homo sapiens_hsa000621.11445981
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10580276
39Caffeine metabolism_Homo sapiens_hsa002321.08979875
40Cell cycle_Homo sapiens_hsa041101.06975875
41beta-Alanine metabolism_Homo sapiens_hsa004101.01999679
42TGF-beta signaling pathway_Homo sapiens_hsa043501.01468897
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98628931
44Spliceosome_Homo sapiens_hsa030400.98091651
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91870735
46Protein export_Homo sapiens_hsa030600.91111324
47Tryptophan metabolism_Homo sapiens_hsa003800.89451323
48Peroxisome_Homo sapiens_hsa041460.88238810
49Lysine degradation_Homo sapiens_hsa003100.87303520
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87271561
51Wnt signaling pathway_Homo sapiens_hsa043100.85043524
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83284226
53Basal cell carcinoma_Homo sapiens_hsa052170.82794978
54Fatty acid metabolism_Homo sapiens_hsa012120.82570258
55Nitrogen metabolism_Homo sapiens_hsa009100.79629193
56Nicotine addiction_Homo sapiens_hsa050330.79220499
57Regulation of autophagy_Homo sapiens_hsa041400.79112145
58p53 signaling pathway_Homo sapiens_hsa041150.78378510
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76819673
60Taste transduction_Homo sapiens_hsa047420.72668779
61Nucleotide excision repair_Homo sapiens_hsa034200.71233095
62Oocyte meiosis_Homo sapiens_hsa041140.70982649
63Vitamin B6 metabolism_Homo sapiens_hsa007500.69823904
64Fatty acid degradation_Homo sapiens_hsa000710.69763735
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66596767
66Pyrimidine metabolism_Homo sapiens_hsa002400.66059217
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65052719
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62442175
69Glutathione metabolism_Homo sapiens_hsa004800.60802416
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60511305
71Metabolic pathways_Homo sapiens_hsa011000.59479616
72Hedgehog signaling pathway_Homo sapiens_hsa043400.58320788
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57378853
74Parkinsons disease_Homo sapiens_hsa050120.57074685
75Arginine biosynthesis_Homo sapiens_hsa002200.55607376
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55579903
77Tight junction_Homo sapiens_hsa045300.51891363
78Calcium signaling pathway_Homo sapiens_hsa040200.50409942
79Vitamin digestion and absorption_Homo sapiens_hsa049770.50391953
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49217598
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47810963
82Retinol metabolism_Homo sapiens_hsa008300.47176993
83Chemical carcinogenesis_Homo sapiens_hsa052040.47067461
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.47051427
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46497532
86GABAergic synapse_Homo sapiens_hsa047270.46421248
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40723971
88Linoleic acid metabolism_Homo sapiens_hsa005910.40267486
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40159409
90Ether lipid metabolism_Homo sapiens_hsa005650.38765687
91Gastric acid secretion_Homo sapiens_hsa049710.37433477
92Hippo signaling pathway_Homo sapiens_hsa043900.37350522
93Glycerolipid metabolism_Homo sapiens_hsa005610.36003390
94Histidine metabolism_Homo sapiens_hsa003400.34370734
95ABC transporters_Homo sapiens_hsa020100.33371599
96Oxidative phosphorylation_Homo sapiens_hsa001900.33267143
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.32678029
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31480364
99Glucagon signaling pathway_Homo sapiens_hsa049220.29558095
100Huntingtons disease_Homo sapiens_hsa050160.29052028

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