CLDN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.98980082
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.74934261
3L-phenylalanine catabolic process (GO:0006559)5.74934261
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.42241593
5L-phenylalanine metabolic process (GO:0006558)5.42241593
6aromatic amino acid family catabolic process (GO:0009074)5.21052480
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.07308890
8* multicellular organismal water homeostasis (GO:0050891)4.97049751
9bile acid biosynthetic process (GO:0006699)4.81711324
10tryptophan catabolic process (GO:0006569)4.81707228
11indole-containing compound catabolic process (GO:0042436)4.81707228
12indolalkylamine catabolic process (GO:0046218)4.81707228
13negative regulation of fibrinolysis (GO:0051918)4.80522630
14regulation of fibrinolysis (GO:0051917)4.79644351
15kynurenine metabolic process (GO:0070189)4.77779067
16regulation of protein activation cascade (GO:2000257)4.77270613
17high-density lipoprotein particle remodeling (GO:0034375)4.75135433
18protein carboxylation (GO:0018214)4.68782902
19peptidyl-glutamic acid carboxylation (GO:0017187)4.68782902
20phospholipid efflux (GO:0033700)4.66311143
21glyoxylate metabolic process (GO:0046487)4.63449203
22tryptophan metabolic process (GO:0006568)4.58410335
23regulation of complement activation (GO:0030449)4.49689405
24complement activation, alternative pathway (GO:0006957)4.47426198
25regulation of triglyceride catabolic process (GO:0010896)4.42689068
26fibrinolysis (GO:0042730)4.42503228
27hemidesmosome assembly (GO:0031581)4.40889860
28urea cycle (GO:0000050)4.36916738
29urea metabolic process (GO:0019627)4.36916738
30sulfur amino acid catabolic process (GO:0000098)4.31980063
31cysteine metabolic process (GO:0006534)4.29864598
32reverse cholesterol transport (GO:0043691)4.21282970
33intestinal cholesterol absorption (GO:0030299)4.20149756
34alpha-linolenic acid metabolic process (GO:0036109)4.18349278
35* water homeostasis (GO:0030104)4.16537335
36exogenous drug catabolic process (GO:0042738)4.09487887
37amino-acid betaine metabolic process (GO:0006577)4.03275710
38regulation of cholesterol esterification (GO:0010872)3.99030464
39plasma lipoprotein particle remodeling (GO:0034369)3.97452806
40protein-lipid complex remodeling (GO:0034368)3.97452806
41macromolecular complex remodeling (GO:0034367)3.97452806
42bile acid metabolic process (GO:0008206)3.97239966
43nitrogen cycle metabolic process (GO:0071941)3.96105705
44uronic acid metabolic process (GO:0006063)3.93311070
45glucuronate metabolic process (GO:0019585)3.93311070
46keratinization (GO:0031424)3.90820887
47drug catabolic process (GO:0042737)3.90579531
48negative regulation of lipase activity (GO:0060192)3.90122632
49bundle of His cell to Purkinje myocyte communication (GO:0086069)3.87898054
50homocysteine metabolic process (GO:0050667)3.87776059
51cell adhesion mediated by integrin (GO:0033627)3.84711472
52negative regulation of protein activation cascade (GO:2000258)3.83666668
53primary alcohol catabolic process (GO:0034310)3.82019129
54serine family amino acid catabolic process (GO:0009071)3.81218537
55tyrosine metabolic process (GO:0006570)3.81079311
56acylglycerol homeostasis (GO:0055090)3.80772278
57triglyceride homeostasis (GO:0070328)3.80772278
58fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.80047384
59plasma lipoprotein particle clearance (GO:0034381)3.78130094
60skin morphogenesis (GO:0043589)3.78114090
61aromatic amino acid family metabolic process (GO:0009072)3.74989373
62molting cycle (GO:0042303)3.72151152
63hair cycle (GO:0042633)3.72151152
64gap junction assembly (GO:0016264)3.71785262
65epithelial cell differentiation involved in prostate gland development (GO:0060742)3.68934254
66imidazole-containing compound metabolic process (GO:0052803)3.68710622
67negative regulation of sterol transport (GO:0032372)3.68336507
68negative regulation of cholesterol transport (GO:0032375)3.68336507
69fatty acid elongation (GO:0030497)3.67373973
70regulation of plasminogen activation (GO:0010755)3.62363653
71epoxygenase P450 pathway (GO:0019373)3.58754605
72positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.57835640
73cholesterol efflux (GO:0033344)3.57634469
74negative regulation of coagulation (GO:0050819)3.56990300
75negative regulation of wound healing (GO:0061045)3.56044100
76ethanol metabolic process (GO:0006067)3.55261415
77positive regulation of lipid catabolic process (GO:0050996)3.52432738
78regulation of phospholipase A2 activity (GO:0032429)3.52268113
79cell-substrate junction assembly (GO:0007044)3.47020070
80bile acid and bile salt transport (GO:0015721)3.46641209
81polyketide metabolic process (GO:0030638)3.46021205
82doxorubicin metabolic process (GO:0044598)3.46021205
83daunorubicin metabolic process (GO:0044597)3.46021205
84response to phenylpropanoid (GO:0080184)3.45885540
85linoleic acid metabolic process (GO:0043651)3.43235753
86cellular modified amino acid catabolic process (GO:0042219)3.41601122
87plasma lipoprotein particle assembly (GO:0034377)3.41522354
88lysine catabolic process (GO:0006554)3.40014341
89lysine metabolic process (GO:0006553)3.40014341
90regulation of cholesterol homeostasis (GO:2000188)3.39544339
91blood coagulation, intrinsic pathway (GO:0007597)3.38916384
92alpha-amino acid catabolic process (GO:1901606)3.36727412
93indolalkylamine metabolic process (GO:0006586)3.36245729
94glutamate metabolic process (GO:0006536)3.32395715
95benzene-containing compound metabolic process (GO:0042537)3.30895393
96keratinocyte proliferation (GO:0043616)3.30785037
97very-low-density lipoprotein particle assembly (GO:0034379)3.30632047
98protein activation cascade (GO:0072376)3.29731141
99* regulation of water loss via skin (GO:0033561)3.28094666
100* establishment of skin barrier (GO:0061436)3.26994623
101very long-chain fatty acid metabolic process (GO:0000038)3.26524322
102epidermis development (GO:0008544)3.25484722
103complement activation (GO:0006956)3.25395677
104negative regulation of keratinocyte proliferation (GO:0010839)3.24036146
105ethanol oxidation (GO:0006069)3.23056442
106cellular ketone body metabolic process (GO:0046950)3.22881952
107cholesterol homeostasis (GO:0042632)3.22698954
108cellular biogenic amine catabolic process (GO:0042402)3.22325831
109amine catabolic process (GO:0009310)3.22325831
110positive regulation of blood coagulation (GO:0030194)3.22055090
111positive regulation of hemostasis (GO:1900048)3.22055090
112cellular glucuronidation (GO:0052695)3.20709495
113regulation of apoptotic cell clearance (GO:2000425)3.18210899
114sterol homeostasis (GO:0055092)3.16658663
115positive regulation of triglyceride lipase activity (GO:0061365)3.16020223
116positive regulation of lipoprotein lipase activity (GO:0051006)3.16020223
117negative regulation of complement activation (GO:0045916)3.15640457
118negative regulation of hemostasis (GO:1900047)3.15069956
119negative regulation of blood coagulation (GO:0030195)3.15069956
120omega-hydroxylase P450 pathway (GO:0097267)3.14952566
121keratinocyte differentiation (GO:0030216)3.12309471
122epithelial cell-cell adhesion (GO:0090136)3.11772908
123carnitine metabolic process (GO:0009437)3.11510904
124positive regulation of fatty acid beta-oxidation (GO:0032000)3.11212095
125cellular amino acid catabolic process (GO:0009063)3.10718766
126complement activation, classical pathway (GO:0006958)3.09932173
127polarized epithelial cell differentiation (GO:0030859)3.09850751
128low-density lipoprotein particle remodeling (GO:0034374)3.09546302
129aminoglycoside antibiotic metabolic process (GO:0030647)3.08495729
130establishment of planar polarity (GO:0001736)3.08134107
131establishment of tissue polarity (GO:0007164)3.08134107
132surfactant homeostasis (GO:0043129)3.06452202
133positive regulation of coagulation (GO:0050820)3.03694987
134planar cell polarity pathway involved in neural tube closure (GO:0090179)3.03046963
135epidermal cell differentiation (GO:0009913)2.99727816
136phenylpropanoid metabolic process (GO:0009698)2.98333794
137lateral sprouting from an epithelium (GO:0060601)2.98250181
138atrioventricular valve morphogenesis (GO:0003181)2.95741916
139acute-phase response (GO:0006953)2.90443215
140positive regulation of extracellular matrix organization (GO:1903055)2.90136412
141regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.88540392
142regulation of transforming growth factor beta1 production (GO:0032908)2.88479469
143regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.81042095
144retinal metabolic process (GO:0042574)2.80195014
145COPI coating of Golgi vesicle (GO:0048205)2.75704575
146Golgi transport vesicle coating (GO:0048200)2.75704575
147intermediate filament organization (GO:0045109)2.73205847
148regulation of cholesterol biosynthetic process (GO:0045540)2.69557864
149regulation of humoral immune response (GO:0002920)2.69346504
150peptide cross-linking (GO:0018149)2.68342504
151drug metabolic process (GO:0017144)2.68172417

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.58626435
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.60377312
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.27068914
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.66693318
5* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.50482561
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.33452383
7* LXR_22158963_ChIP-Seq_LIVER_Mouse4.16933769
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.55017352
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.22724359
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.71305183
11* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.69672068
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.06356174
13* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.97648297
14ESR2_21235772_ChIP-Seq_MCF-7_Human1.90069831
15P63_26484246_Chip-Seq_KERATINOCYTES_Human1.79957796
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78643911
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.68284111
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66908438
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65989945
20ZNF263_19887448_ChIP-Seq_K562_Human1.59553406
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.59379211
22GATA1_22025678_ChIP-Seq_K562_Human1.55891150
23SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.48226641
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48024081
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45717754
26CLOCK_20551151_ChIP-Seq_293T_Human1.45270095
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38924274
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38411271
29* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31694999
30* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31694999
31UBF1/2_26484160_Chip-Seq_HMECs_Human1.26446275
32* SOX2_20726797_ChIP-Seq_SW620_Human1.23185464
33HTT_18923047_ChIP-ChIP_STHdh_Human1.21672331
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20198619
35* GATA4_25053715_ChIP-Seq_YYC3_Human1.18055585
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16620198
37TP63_23658742_ChIP-Seq_EP156T_Human1.15414640
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14357195
39* FOXA2_19822575_ChIP-Seq_HepG2_Human1.13494982
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13088705
41CJUN_26792858_Chip-Seq_BT549_Human1.10868482
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10487287
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.09435465
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08643167
45EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07887138
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.07018581
47SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06645203
48BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.05473751
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02015188
50* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01885445
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99386237
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98528109
53NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96829460
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96829460
55BCAT_22108803_ChIP-Seq_LS180_Human0.95047553
56FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92049336
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91974754
58TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90895891
59ELK3_25401928_ChIP-Seq_HUVEC_Human0.90857593
60AHR_22903824_ChIP-Seq_MCF-7_Human0.89948073
61AR_21909140_ChIP-Seq_LNCAP_Human0.89544003
62ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88875852
63TCF4_18268006_ChIP-ChIP_LS174T_Human0.88739367
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88267499
65GATA3_24758297_ChIP-Seq_MCF-7_Human0.88049055
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87654141
67TBX20_22328084_ChIP-Seq_HEART_Mouse0.87324483
68TBX20_22080862_ChIP-Seq_HEART_Mouse0.87324483
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85336996
70RXR_22108803_ChIP-Seq_LS180_Human0.85017547
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84828941
72AR_21572438_ChIP-Seq_LNCaP_Human0.83459650
73TP53_16413492_ChIP-PET_HCT116_Human0.83451925
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83271098
75ERG_21242973_ChIP-ChIP_JURKAT_Human0.83163324
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82847750
77GATA6_25053715_ChIP-Seq_YYC3_Human0.81916275
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81631381
79CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81486384
80* TP53_18474530_ChIP-ChIP_U2OS_Human0.81048688
81STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80851927
82RUNX1_27514584_Chip-Seq_MCF-7_Human0.80623080
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80272526
84CEBPB_22108803_ChIP-Seq_LS180_Human0.80269382
85PIAS1_25552417_ChIP-Seq_VCAP_Human0.79689297
86FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79569126
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79494314
88SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79420790
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79198376
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78994027
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78735342
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.78336700
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77912626
94ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77750493
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77026519
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76914526
97RACK7_27058665_Chip-Seq_MCF-7_Human0.75954688
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75454732
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75000588
100* HNF4A_19822575_ChIP-Seq_HepG2_Human0.73031721
101FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72564800
102NFIB_24661679_ChIP-Seq_LUNG_Mouse0.72549336
103* EGR1_19032775_ChIP-ChIP_M12_Human0.71846431
104* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.71072784
105TP63_22573176_ChIP-Seq_HFKS_Human0.70621405
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.70155268
107LXR_22292898_ChIP-Seq_THP-1_Human0.69491665
108HIF1A_21447827_ChIP-Seq_MCF-7_Human0.69297618
109* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.69243308
110ATF3_27146783_Chip-Seq_COLON_Human0.68325343
111KLF5_25053715_ChIP-Seq_YYC3_Human0.67280251
112TP53_20018659_ChIP-ChIP_R1E_Mouse0.66191997
113ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.64122212
114TCF4_22108803_ChIP-Seq_LS180_Human0.63244926
115JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63058473
116FOXA1_25552417_ChIP-Seq_VCAP_Human0.62547153
117P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.61017689
118CDX2_19796622_ChIP-Seq_MESCs_Mouse0.58728588
119GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.58445761
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58226419
121GATA2_21666600_ChIP-Seq_HMVEC_Human0.57916437
122* SMAD3_21741376_ChIP-Seq_HESCs_Human0.56229874
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.56114911

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.00589025
2MP0005360_urolithiasis4.91489359
3* MP0002796_impaired_skin_barrier4.39717107
4MP0005085_abnormal_gallbladder_physiolo4.34292297
5MP0005365_abnormal_bile_salt3.81232794
6MP0010234_abnormal_vibrissa_follicle3.65052405
7MP0002254_reproductive_system_inflammat3.33335137
8MP0004381_abnormal_hair_follicle3.19244871
9MP0003941_abnormal_skin_development3.17984216
10MP0005275_abnormal_skin_tensile3.13233017
11MP0008875_abnormal_xenobiotic_pharmacok3.02803512
12MP0000579_abnormal_nail_morphology2.98450163
13MP0000383_abnormal_hair_follicle2.91157711
14MP0002098_abnormal_vibrissa_morphology2.66616301
15MP0003252_abnormal_bile_duct2.65322495
16MP0010678_abnormal_skin_adnexa2.62589638
17MP0002060_abnormal_skin_morphology2.61698018
18* MP0005501_abnormal_skin_physiology2.55110525
19MP0003705_abnormal_hypodermis_morpholog2.48086748
20MP0010329_abnormal_lipoprotein_level2.37387958
21MP0003453_abnormal_keratinocyte_physiol2.30743427
22* MP0001216_abnormal_epidermal_layer2.27344753
23MP0003011_delayed_dark_adaptation2.23007748
24MP0004019_abnormal_vitamin_homeostasis2.20122370
25MP0000647_abnormal_sebaceous_gland2.19236765
26MP0003191_abnormal_cellular_cholesterol2.10484054
27MP0003806_abnormal_nucleotide_metabolis2.08632389
28MP0000377_abnormal_hair_follicle2.04942148
29MP0009840_abnormal_foam_cell1.97239568
30MP0000427_abnormal_hair_cycle1.93103820
31MP0000566_synostosis1.91908166
32MP0005451_abnormal_body_composition1.86928014
33MP0009780_abnormal_chondrocyte_physiolo1.86780787
34MP0005083_abnormal_biliary_tract1.86349418
35* MP0010771_integument_phenotype1.85796912
36MP0001666_abnormal_nutrient_absorption1.85615901
37MP0003195_calcinosis1.85589728
38MP0000467_abnormal_esophagus_morphology1.77690433
39MP0005409_darkened_coat_color1.72836326
40MP0004947_skin_inflammation1.67904894
41MP0005332_abnormal_amino_acid1.51041061
42MP0009053_abnormal_anal_canal1.48867060
43MP0002009_preneoplasia1.35565179
44MP0000609_abnormal_liver_physiology1.29245491
45MP0002118_abnormal_lipid_homeostasis1.28724573
46MP0001346_abnormal_lacrimal_gland1.26875927
47MP0000762_abnormal_tongue_morphology1.21915849
48MP0001243_abnormal_dermal_layer1.21363010
49* MP0009931_abnormal_skin_appearance1.21043379
50MP0003566_abnormal_cell_adhesion1.19412632
51MP0003950_abnormal_plasma_membrane1.13726087
52MP0002138_abnormal_hepatobiliary_system1.12909497
53MP0001191_abnormal_skin_condition1.10963399
54MP0009384_cardiac_valve_regurgitation1.10542402
55* MP0000367_abnormal_coat/_hair1.03046713
56MP0005647_abnormal_sex_gland0.97580366
57MP0000858_altered_metastatic_potential0.97300697
58MP0009379_abnormal_foot_pigmentation0.94750744
59MP0001849_ear_inflammation0.93819987
60MP0002876_abnormal_thyroid_physiology0.93238166
61MP0002089_abnormal_postnatal_growth/wei0.92815477
62MP0005257_abnormal_intraocular_pressure0.91281227
63MP0005319_abnormal_enzyme/_coenzyme0.88143067
64MP0002877_abnormal_melanocyte_morpholog0.84024716
65MP0005023_abnormal_wound_healing0.83477360
66MP0009643_abnormal_urine_homeostasis0.83397300
67MP0005076_abnormal_cell_differentiation0.81498483
68MP0001851_eye_inflammation0.78270145
69MP0001340_abnormal_eyelid_morphology0.77715670
70MP0004264_abnormal_extraembryonic_tissu0.77691549
71MP0005164_abnormal_response_to0.76822207
72MP0004185_abnormal_adipocyte_glucose0.76665870
73MP0009764_decreased_sensitivity_to0.74669179
74MP0003868_abnormal_feces_composition0.73703270
75MP0010368_abnormal_lymphatic_system0.73502157
76MP0005584_abnormal_enzyme/coenzyme_acti0.72319396
77MP0002234_abnormal_pharynx_morphology0.71487059
78MP0001915_intracranial_hemorrhage0.70371113
79MP0003091_abnormal_cell_migration0.70241068
80MP0005408_hypopigmentation0.68819615
81MP0001764_abnormal_homeostasis0.68300326
82MP0001661_extended_life_span0.68261683
83MP0004272_abnormal_basement_membrane0.67718935
84MP0002168_other_aberrant_phenotype0.67575160
85MP0000604_amyloidosis0.67106623
86MP0010030_abnormal_orbit_morphology0.66704154
87MP0000627_abnormal_mammary_gland0.66244143
88MP0000537_abnormal_urethra_morphology0.63930980
89MP0005636_abnormal_mineral_homeostasis0.63183222
90MP0002896_abnormal_bone_mineralization0.62234669
91MP0005197_abnormal_uvea_morphology0.59199358
92MP0009763_increased_sensitivity_to0.57043898
93MP0003436_decreased_susceptibility_to0.56883099
94MP0003638_abnormal_response/metabolism_0.56386411
95MP0005248_abnormal_Harderian_gland0.55766696
96MP0002166_altered_tumor_susceptibility0.55569241
97MP0000538_abnormal_urinary_bladder0.55471053
98MP0003045_fibrosis0.55306543
99MP0005058_abnormal_lysosome_morphology0.54995895
100MP0004782_abnormal_surfactant_physiolog0.54647924
101MP0003300_gastrointestinal_ulcer0.54187986
102MP0002282_abnormal_trachea_morphology0.53047241
103MP0008438_abnormal_cutaneous_collagen0.52231897
104MP0005075_abnormal_melanosome_morpholog0.51740796
105MP0001853_heart_inflammation0.51399192
106MP0004883_abnormal_blood_vessel0.51277316
107MP0000462_abnormal_digestive_system0.50442183
108MP0000598_abnormal_liver_morphology0.50383724
109MP0009697_abnormal_copulation0.50058087
110MP0005220_abnormal_exocrine_pancreas0.49620556
111MP0002697_abnormal_eye_size0.49466857
112MP0000003_abnormal_adipose_tissue0.48556132
113MP0003186_abnormal_redox_activity0.48441447
114MP0009765_abnormal_xenobiotic_induced0.48053871
115MP0010352_gastrointestinal_tract_polyps0.47878443
116MP0001881_abnormal_mammary_gland0.47355106
117MP0003755_abnormal_palate_morphology0.46668843
118MP0008469_abnormal_protein_level0.43557262
119MP0002136_abnormal_kidney_physiology0.43383081
120MP0002233_abnormal_nose_morphology0.42114914
121MP0002249_abnormal_larynx_morphology0.41310740
122MP0005193_abnormal_anterior_eye0.41237900
123MP0003724_increased_susceptibility_to0.40635781
124MP0005187_abnormal_penis_morphology0.40064080
125MP0009642_abnormal_blood_homeostasis0.39464651
126MP0001756_abnormal_urination0.38813637
127MP0002971_abnormal_brown_adipose0.38788546
128MP0003656_abnormal_erythrocyte_physiolo0.36423594

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.09241142
2Deep venous thrombosis (HP:0002625)5.85557964
3Xanthomatosis (HP:0000991)5.50914230
4Prolonged partial thromboplastin time (HP:0003645)5.13207747
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.97852241
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.95572281
7Hypobetalipoproteinemia (HP:0003563)4.65126288
8Right ventricular cardiomyopathy (HP:0011663)4.51259102
9Onycholysis (HP:0001806)4.50842904
10Epidermoid cyst (HP:0200040)4.44600288
11Complement deficiency (HP:0004431)4.37047081
12Plantar hyperkeratosis (HP:0007556)4.36532482
13Fragile nails (HP:0001808)4.12878842
14Woolly hair (HP:0002224)4.11900105
15* Hypotrichosis (HP:0001006)4.08501108
16Hyperlipoproteinemia (HP:0010980)4.03750142
17Hypolipoproteinemia (HP:0010981)3.94743671
18Hypoalphalipoproteinemia (HP:0003233)3.81832877
19Palmoplantar hyperkeratosis (HP:0000972)3.72730209
20Abnormality of nail color (HP:0100643)3.62889427
21Abnormality of the common coagulation pathway (HP:0010990)3.62548016
22Joint hemorrhage (HP:0005261)3.61095538
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.57480228
24Palmar hyperkeratosis (HP:0010765)3.45063628
25Milia (HP:0001056)3.43979708
26Abnormality of complement system (HP:0005339)3.42847380
27Lip pit (HP:0100267)3.41916253
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.28951114
29Vascular calcification (HP:0004934)3.27484814
30Fat malabsorption (HP:0002630)3.22155266
31Amelogenesis imperfecta (HP:0000705)3.21902010
32Hyperammonemia (HP:0001987)3.11875420
33Hyperglycinemia (HP:0002154)3.10910972
34Congenital ichthyosiform erythroderma (HP:0007431)3.07927652
35Abnormality of the salivary glands (HP:0010286)3.07061553
36Pili torti (HP:0003777)3.01402141
37Cardiovascular calcification (HP:0011915)2.97793821
38Abnormality of sulfur amino acid metabolism (HP:0004339)2.96103818
39Conjugated hyperbilirubinemia (HP:0002908)2.89886031
40Erythroderma (HP:0001019)2.89194104
41Ketosis (HP:0001946)2.86000551
42Abnormality of aspartate family amino acid metabolism (HP:0010899)2.85633975
43Hyperglycinuria (HP:0003108)2.82768354
44Myocardial infarction (HP:0001658)2.81753362
45Alopecia of scalp (HP:0002293)2.81707103
46Abnormality of methionine metabolism (HP:0010901)2.80856372
47Absent eyelashes (HP:0000561)2.79330853
48Abnormality of serine family amino acid metabolism (HP:0010894)2.76987806
49Abnormality of glycine metabolism (HP:0010895)2.76987806
50Nail dystrophy (HP:0008404)2.75440381
51Erythema (HP:0010783)2.65689441
52Hypoglycemic coma (HP:0001325)2.65110017
53Increased IgE level (HP:0003212)2.63959196
54Hypercholesterolemia (HP:0003124)2.61265954
55Atrophic scars (HP:0001075)2.57327466
56Abnormality of the labia majora (HP:0012881)2.57120420
57Abnormality of the intrinsic pathway (HP:0010989)2.55848394
58Abnormality of secondary sexual hair (HP:0009888)2.54208538
59Abnormality of the axillary hair (HP:0100134)2.54208538
60Abnormal blistering of the skin (HP:0008066)2.51468706
61Neonatal death (HP:0003811)2.50572479
62Thick nail (HP:0001805)2.50386566
63Abnormality of the dental root (HP:0006486)2.49326247
64Taurodontia (HP:0000679)2.49326247
65Abnormality of permanent molar morphology (HP:0011071)2.49326247
66Corneal erosion (HP:0200020)2.47999333
67* Sparse eyelashes (HP:0000653)2.46183255
68Abnormal hair laboratory examination (HP:0003328)2.41904761
69Spontaneous abortion (HP:0005268)2.41405045
70Pterygium (HP:0001059)2.40802243
71Selective tooth agenesis (HP:0001592)2.40448492
72Ridged nail (HP:0001807)2.40079621
73Steatorrhea (HP:0002570)2.39683125
74Amyloidosis (HP:0011034)2.34263084
75Nasolacrimal duct obstruction (HP:0000579)2.34243409
76Flat acetabular roof (HP:0003180)2.33970362
77* Hypoplasia of dental enamel (HP:0006297)2.32289576
78Pruritus (HP:0000989)2.31549513
79Popliteal pterygium (HP:0009756)2.30978712
80Abnormality of molar (HP:0011077)2.30889029
81Abnormality of molar morphology (HP:0011070)2.30889029
82Abnormality of the dental pulp (HP:0006479)2.29463796
83Advanced eruption of teeth (HP:0006288)2.28374446
84Hyperbilirubinemia (HP:0002904)2.27488960
85Malnutrition (HP:0004395)2.26527776
86Rickets (HP:0002748)2.25991871
87Sparse scalp hair (HP:0002209)2.25724882
88Systemic lupus erythematosus (HP:0002725)2.24425566
89Natal tooth (HP:0000695)2.24171281
90Hepatocellular carcinoma (HP:0001402)2.22702558
91Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.21925301
92Delayed CNS myelination (HP:0002188)2.19174446
93Abnormality of fatty-acid metabolism (HP:0004359)2.18646664
94Abnormality of pyrimidine metabolism (HP:0004353)2.18360489
95Nephritis (HP:0000123)2.17647414
96Aplasia involving bones of the extremities (HP:0009825)2.16643251
97Aplasia involving bones of the upper limbs (HP:0009823)2.16643251
98Aplasia of the phalanges of the hand (HP:0009802)2.16643251
99Gangrene (HP:0100758)2.14705241
100Xerostomia (HP:0000217)2.14463710
101Septate vagina (HP:0001153)2.13744882
102Neonatal onset (HP:0003623)2.13387792
103Ankyloglossia (HP:0010296)2.11647831
104Split foot (HP:0001839)2.11108314
105Glomerulonephritis (HP:0000099)2.10538047
106Blepharitis (HP:0000498)2.08772733
107Abnormality of nucleobase metabolism (HP:0010932)2.07255334
108Conical tooth (HP:0000698)2.06969676
109Abnormality of the distal phalanges of the toes (HP:0010182)2.06667968
110Palmoplantar keratoderma (HP:0000982)2.05926501
111Gingival bleeding (HP:0000225)2.01992538
112Abnormality of purine metabolism (HP:0004352)2.01702757
113Fragile skin (HP:0001030)2.00873410
114Ketoacidosis (HP:0001993)1.99613564
115Abnormality of the gastric mucosa (HP:0004295)1.98984669
116Conjunctival hamartoma (HP:0100780)1.98612729
117Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.98248508
118Arterial tortuosity (HP:0005116)1.97924448
119Mitral stenosis (HP:0001718)1.97117045
120Hypophosphatemic rickets (HP:0004912)1.95071994
121Hypohidrosis (HP:0000966)1.93970141
122Skin nodule (HP:0200036)1.93909356
123Abnormality of the lacrimal duct (HP:0011481)1.92370686
124Hypoplastic labia majora (HP:0000059)1.92079018
125Bifid scrotum (HP:0000048)1.91501964
126Curly hair (HP:0002212)1.90980776
127Short nail (HP:0001799)1.89856639
128Esophageal varix (HP:0002040)1.88097847
129Acanthocytosis (HP:0001927)1.87627683
130Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86813531
131Abnormality of the Achilles tendon (HP:0005109)1.85650476
132Hyporeflexia of lower limbs (HP:0002600)1.83921144
133Menorrhagia (HP:0000132)1.82782768
134Hypochromic microcytic anemia (HP:0004840)1.81485257
135Abnormality of carpal bone ossification (HP:0006257)1.79479302
136Brittle hair (HP:0002299)1.79263299
137Abnormality of serum amino acid levels (HP:0003112)1.78816746
138Ectropion (HP:0000656)1.77621397
139Labial hypoplasia (HP:0000066)1.75135954
140Abnormality of the nasal septum (HP:0000419)1.74074097
141Hemorrhage of the eye (HP:0011885)1.73935373
142Dry hair (HP:0011359)1.72285749
143Absent hair (HP:0002298)1.71287483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.85763536
2FGFR43.44591968
3MAP3K33.32147528
4ERN12.93765708
5MAPKAPK32.93708259
6EPHB22.83536057
7MST42.79642113
8LATS12.77802766
9BCKDK2.64520503
10FER2.60392063
11SIK12.53786865
12EPHA22.26093674
13FGFR22.23818982
14MAP3K22.13540752
15ERBB42.04194606
16PIK3CG2.04039984
17TRPM71.99210501
18MAP3K121.98476252
19LMTK21.97529782
20PTK61.76809474
21EPHA31.73712014
22TGFBR11.72403414
23MET1.70373236
24CDK121.68840193
25PAK41.57896773
26ICK1.51799035
27TESK11.46327915
28FRK1.45882457
29SMG11.44319582
30EPHB11.41737464
31TYK21.40305402
32LRRK21.39628733
33NTRK11.38652624
34MAP3K61.37819301
35TGFBR21.35042587
36MAP3K71.34546017
37RPS6KB21.33723651
38MAP3K141.31034659
39FGFR31.28231972
40NEK91.26658381
41MAP3K11.25677079
42ERBB21.22650111
43MAPK151.17611857
44STK101.17332534
45TRIB31.16643571
46DYRK1B1.16291738
47MYLK1.10367165
48BCR1.09752045
49EEF2K1.08975162
50MAP3K91.07115875
51MAPK111.04269117
52ERBB31.01248121
53INSRR0.97706250
54CDK60.95485705
55STK380.93631834
56DMPK0.92297759
57MAP2K20.92121970
58PTK20.87165055
59JAK20.86652540
60MAP2K40.86099784
61GRK10.81800474
62MTOR0.80007362
63GSK3A0.79676907
64TBK10.73312227
65FGFR10.69619723
66IKBKE0.68074279
67TAOK30.67075347
68MAPK40.66519703
69PRKAA20.64707791
70CHUK0.64013279
71ARAF0.61832523
72ABL20.61404625
73MAP2K60.61330827
74MAP3K130.60250514
75JAK10.58630397
76EIF2AK10.57013901
77NEK60.55389427
78SCYL20.55276175
79PRKCZ0.55260627
80MAP2K30.54960294
81PDGFRB0.54006934
82CDK30.52118882
83PAK20.51896512
84MAP2K10.51125901
85CDC42BPA0.51076708
86RIPK10.50610662
87STK38L0.49956888
88MAPK120.48632905
89MAP3K110.48381864
90STK30.47748537
91PDGFRA0.47698503
92MAPKAPK50.47445475
93LATS20.45882254
94PIM20.44807007
95PRKACG0.44336351
96BMX0.43677601
97ILK0.42958044
98SIK30.42909565
99RPS6KA20.42411446
100PKN10.42273314
101BLK0.42147791
102PRKD10.41755480
103SGK30.41563897
104RPS6KB10.41269330
105STK240.40859770
106MAPKAPK20.40733634
107IKBKB0.40206585
108TTN0.39933284
109PIK3CA0.39882247
110PKN20.39613721
111IGF1R0.39240935
112EPHA40.37342527
113MELK0.36824534
114RPS6KA10.35026394
115IRAK10.34962270
116EGFR0.34604746
117RET0.34469411
118KSR20.34173351
119CDK90.34050755
120MAPK70.33795701
121ABL10.33603525
122NLK0.32174186
123CDK80.32068282
124MAP3K50.31667501
125FLT30.31138988
126ITK0.30713256
127PRPF4B0.30639033
128PRKCQ0.30192808
129PRKCE0.29426715
130PBK0.28058066
131ROCK10.27916152
132BRSK20.27555370
133MAPK30.27462362
134TAOK10.26915127
135IRAK30.26763991
136CSNK1D0.26603606
137SRC0.26148819
138LIMK10.24999779
139PDPK10.23305870

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.35729936
2Nitrogen metabolism_Homo sapiens_hsa009103.43554998
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97637102
4Complement and coagulation cascades_Homo sapiens_hsa046102.95758124
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93996659
6Arginine biosynthesis_Homo sapiens_hsa002202.68132140
7Tryptophan metabolism_Homo sapiens_hsa003802.50234173
8Fatty acid degradation_Homo sapiens_hsa000712.42261805
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.40699449
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.37491791
11Histidine metabolism_Homo sapiens_hsa003402.34750194
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.27802572
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27532030
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14381833
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.12634436
16Chemical carcinogenesis_Homo sapiens_hsa052042.12037380
17Phenylalanine metabolism_Homo sapiens_hsa003602.08791038
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07362298
19Retinol metabolism_Homo sapiens_hsa008302.04977902
20Staphylococcus aureus infection_Homo sapiens_hsa051501.97355919
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96782839
22Fatty acid elongation_Homo sapiens_hsa000621.88503233
23PPAR signaling pathway_Homo sapiens_hsa033201.88107547
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.86599471
25Peroxisome_Homo sapiens_hsa041461.82772685
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81444872
27Butanoate metabolism_Homo sapiens_hsa006501.79991128
28Tyrosine metabolism_Homo sapiens_hsa003501.75641199
29Fatty acid metabolism_Homo sapiens_hsa012121.74965574
30beta-Alanine metabolism_Homo sapiens_hsa004101.73916133
31Caffeine metabolism_Homo sapiens_hsa002321.73863793
32Propanoate metabolism_Homo sapiens_hsa006401.59877298
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38583725
34Steroid biosynthesis_Homo sapiens_hsa001001.36380673
35Bile secretion_Homo sapiens_hsa049761.34611621
36Fat digestion and absorption_Homo sapiens_hsa049751.33983533
37ABC transporters_Homo sapiens_hsa020101.33204292
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32366158
39Sulfur metabolism_Homo sapiens_hsa009201.30719512
40Vitamin digestion and absorption_Homo sapiens_hsa049771.29719160
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25735580
42Selenocompound metabolism_Homo sapiens_hsa004501.18448662
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.18032742
44Starch and sucrose metabolism_Homo sapiens_hsa005001.06464670
45Folate biosynthesis_Homo sapiens_hsa007901.06073850
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00042616
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94783099
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91397644
49Thyroid cancer_Homo sapiens_hsa052160.91096901
50Linoleic acid metabolism_Homo sapiens_hsa005910.87487799
51Pyruvate metabolism_Homo sapiens_hsa006200.82910095
52Glutathione metabolism_Homo sapiens_hsa004800.82365120
53Other glycan degradation_Homo sapiens_hsa005110.80457000
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.77969561
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.77291669
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75194929
57Fatty acid biosynthesis_Homo sapiens_hsa000610.74991569
58Focal adhesion_Homo sapiens_hsa045100.74607460
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70545048
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70527058
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.67486235
62Arginine and proline metabolism_Homo sapiens_hsa003300.66918495
63Carbon metabolism_Homo sapiens_hsa012000.65479427
64Biosynthesis of amino acids_Homo sapiens_hsa012300.63268925
65Lysine degradation_Homo sapiens_hsa003100.61253356
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59701186
67Sulfur relay system_Homo sapiens_hsa041220.56685528
68Glycerolipid metabolism_Homo sapiens_hsa005610.53507977
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51432698
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46856423
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46266134
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.44865571
73Fructose and mannose metabolism_Homo sapiens_hsa000510.44557619
74ECM-receptor interaction_Homo sapiens_hsa045120.44176444
75Arachidonic acid metabolism_Homo sapiens_hsa005900.43234256
76Circadian rhythm_Homo sapiens_hsa047100.42826659
77Sphingolipid metabolism_Homo sapiens_hsa006000.41576233
78* Tight junction_Homo sapiens_hsa045300.40536335
79Pancreatic cancer_Homo sapiens_hsa052120.38979224
80N-Glycan biosynthesis_Homo sapiens_hsa005100.37007526
81Renal cell carcinoma_Homo sapiens_hsa052110.36142442
82Insulin resistance_Homo sapiens_hsa049310.36134235
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.35887934
84Vitamin B6 metabolism_Homo sapiens_hsa007500.34039350
85Amoebiasis_Homo sapiens_hsa051460.33897389
86Pancreatic secretion_Homo sapiens_hsa049720.33669308
87Basal cell carcinoma_Homo sapiens_hsa052170.31533630
88Bladder cancer_Homo sapiens_hsa052190.31341556
89Notch signaling pathway_Homo sapiens_hsa043300.30738551
90Metabolic pathways_Homo sapiens_hsa011000.28578685
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26568174
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26324846
93Chronic myeloid leukemia_Homo sapiens_hsa052200.26230585
94Lysosome_Homo sapiens_hsa041420.23784849
95Prion diseases_Homo sapiens_hsa050200.22788054
96Ether lipid metabolism_Homo sapiens_hsa005650.20831804
97VEGF signaling pathway_Homo sapiens_hsa043700.20816952
98Insulin signaling pathway_Homo sapiens_hsa049100.20162653
99Prostate cancer_Homo sapiens_hsa052150.20120147
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20087220
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19364739
102Choline metabolism in cancer_Homo sapiens_hsa052310.18926268
103Pentose phosphate pathway_Homo sapiens_hsa000300.17802975
104Adherens junction_Homo sapiens_hsa045200.16372323
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15746495
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15554434
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.13852751
108Mineral absorption_Homo sapiens_hsa049780.12983421
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12894714
110Proteoglycans in cancer_Homo sapiens_hsa052050.11083689
111One carbon pool by folate_Homo sapiens_hsa006700.05878788
112Glucagon signaling pathway_Homo sapiens_hsa049220.04705470
113Ovarian steroidogenesis_Homo sapiens_hsa049130.03824009
114Protein digestion and absorption_Homo sapiens_hsa049740.03601267
115Hippo signaling pathway_Homo sapiens_hsa043900.01850948
116Small cell lung cancer_Homo sapiens_hsa052220.00815130
117AMPK signaling pathway_Homo sapiens_hsa041520.00789098
118Melanogenesis_Homo sapiens_hsa04916-0.0640659
119TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0525726
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0386484
121Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0270247
122Galactose metabolism_Homo sapiens_hsa00052-0.0242249
123* Hepatitis C_Homo sapiens_hsa05160-0.0175609
124Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0147571
125Pertussis_Homo sapiens_hsa05133-0.0104359
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0021095

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