CLDN10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alanine transport (GO:0032328)6.06257005
2C4-dicarboxylate transport (GO:0015740)5.90433301
3negative regulation of astrocyte differentiation (GO:0048712)5.49542090
4amino acid import (GO:0043090)5.43054144
5L-amino acid import (GO:0043092)5.39122064
6L-serine transport (GO:0015825)5.31229697
7cellular potassium ion homeostasis (GO:0030007)5.16215910
8low-density lipoprotein particle remodeling (GO:0034374)5.15890980
9chaperone-mediated protein transport (GO:0072321)4.98470675
10water-soluble vitamin biosynthetic process (GO:0042364)4.94301907
11aminoglycoside antibiotic metabolic process (GO:0030647)4.87348293
12positive regulation of cellular amide metabolic process (GO:0034250)4.83621915
13pyrimidine-containing compound transmembrane transport (GO:0072531)4.81999544
14sodium ion export (GO:0071436)4.65211489
15serine transport (GO:0032329)4.59852991
16respiratory chain complex IV assembly (GO:0008535)4.59366183
17cobalamin metabolic process (GO:0009235)4.43331503
18cellular response to cholesterol (GO:0071397)4.36663468
19hyperosmotic salinity response (GO:0042538)4.27011976
20cytochrome complex assembly (GO:0017004)4.12060846
21negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.11866630
22chondroitin sulfate catabolic process (GO:0030207)4.11801028
23cell communication by electrical coupling (GO:0010644)4.09069212
24glial cell proliferation (GO:0014009)4.06440774
25negative regulation of interleukin-1 beta production (GO:0032691)4.05137153
26gamma-aminobutyric acid transport (GO:0015812)4.00935185
27daunorubicin metabolic process (GO:0044597)3.97352354
28polyketide metabolic process (GO:0030638)3.97352354
29doxorubicin metabolic process (GO:0044598)3.97352354
30transepithelial transport (GO:0070633)3.96908184
31regulation of mitochondrial translation (GO:0070129)3.94963048
32negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.91937820
33renal absorption (GO:0070293)3.88840052
34regulation of beta-amyloid formation (GO:1902003)3.86751401
35adult feeding behavior (GO:0008343)3.84225520
36cellular sodium ion homeostasis (GO:0006883)3.83943964
37positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.83792554
38positive regulation of growth hormone secretion (GO:0060124)3.82714081
39rRNA modification (GO:0000154)3.80382303
40regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.79413909
41central nervous system myelination (GO:0022010)3.76937375
42axon ensheathment in central nervous system (GO:0032291)3.76937375
43one-carbon compound transport (GO:0019755)3.72598997
44establishment of integrated proviral latency (GO:0075713)3.72137218
45regulation of astrocyte differentiation (GO:0048710)3.70887707
46cellular response to sterol (GO:0036315)3.68689453
47protein complex biogenesis (GO:0070271)3.66133935
48pantothenate metabolic process (GO:0015939)3.65604886
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.62647212
50dermatan sulfate biosynthetic process (GO:0030208)3.59335371
51cellular modified amino acid catabolic process (GO:0042219)3.58390671
52proteasome assembly (GO:0043248)3.56119677
53negative regulation of response to reactive oxygen species (GO:1901032)3.55041143
54metanephric nephron tubule development (GO:0072234)3.55012644
55metanephric tubule development (GO:0072170)3.55012644
56mitochondrial respiratory chain complex assembly (GO:0033108)3.54065719
57dermatan sulfate metabolic process (GO:0030205)3.52209450
58potassium ion import (GO:0010107)3.51855428
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.50877517
60blood vessel maturation (GO:0001955)3.48513442
61regulation of helicase activity (GO:0051095)3.45301591
62negative regulation of interleukin-1 production (GO:0032692)3.45269611
63mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.45039613
64atrial cardiac muscle cell action potential (GO:0086014)3.44398827
65positive regulation of steroid hormone secretion (GO:2000833)3.43752661
66neurotransmitter-gated ion channel clustering (GO:0072578)3.41586906
67regulation of hydrogen peroxide-induced cell death (GO:1903205)3.41426091
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41158435
69negative regulation of sodium ion transport (GO:0010766)3.40958862
70rRNA methylation (GO:0031167)3.40866284
71chromatin remodeling at centromere (GO:0031055)3.39237696
72regulation of glucocorticoid secretion (GO:2000849)3.37640474
73neurotransmitter uptake (GO:0001504)3.37183452
74regulation of oxidative phosphorylation (GO:0002082)3.34624137
75regulation of phospholipid biosynthetic process (GO:0071071)3.31226857
76cGMP-mediated signaling (GO:0019934)3.30490055
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.30218981
78mitochondrial respiratory chain complex I assembly (GO:0032981)3.30218981
79NADH dehydrogenase complex assembly (GO:0010257)3.30218981
80CENP-A containing nucleosome assembly (GO:0034080)3.29164453
81cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25030250
82endocrine hormone secretion (GO:0060986)3.24707748
83response to auditory stimulus (GO:0010996)3.24447350
84regulation of mitotic spindle checkpoint (GO:1903504)3.24442728
85regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24442728
86regulation of response to food (GO:0032095)3.24400139
87negative regulation of glial cell differentiation (GO:0045686)3.23738998
88metanephric nephron epithelium development (GO:0072243)3.22474575
89mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.22403176
90adenine nucleotide transport (GO:0051503)3.20645991
91* calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.19792036
92regulation of heat generation (GO:0031650)3.17693140
93positive regulation of triglyceride biosynthetic process (GO:0010867)3.16018279
94ovulation cycle (GO:0042698)3.12703100
95negative regulation of DNA-dependent DNA replication (GO:2000104)3.10124898
96positive regulation of alcohol biosynthetic process (GO:1902932)3.09587934
97regulation of cellular amino acid metabolic process (GO:0006521)3.07121287
98potassium ion homeostasis (GO:0055075)3.06517408
99purine nucleobase biosynthetic process (GO:0009113)3.04604905
100branched-chain amino acid catabolic process (GO:0009083)3.04544259
101regulation of inositol phosphate biosynthetic process (GO:0010919)3.03914645
102regulation of appetite (GO:0032098)3.02847301
103glutathione derivative metabolic process (GO:1901685)3.01366749
104glutathione derivative biosynthetic process (GO:1901687)3.01366749
105negative regulation of smoothened signaling pathway (GO:0045879)3.00680714
106histone mRNA metabolic process (GO:0008334)3.00648489
107histone exchange (GO:0043486)2.99720917
108regulation of interleukin-6 biosynthetic process (GO:0045408)2.97863601
109DNA deamination (GO:0045006)2.96655894
110acidic amino acid transport (GO:0015800)2.96305960
111termination of RNA polymerase III transcription (GO:0006386)2.95896914
112transcription elongation from RNA polymerase III promoter (GO:0006385)2.95896914
113short-chain fatty acid metabolic process (GO:0046459)2.95882526
114regulation of cilium movement (GO:0003352)2.95307568
115response to nitrosative stress (GO:0051409)2.94311755
116metanephric epithelium development (GO:0072207)2.93886492
117pseudouridine synthesis (GO:0001522)2.93181571
118regulation of amyloid precursor protein catabolic process (GO:1902991)2.92324381
119nodal signaling pathway (GO:0038092)2.91590400
120purine ribonucleotide transport (GO:0015868)2.91353957
121telomere maintenance via telomerase (GO:0007004)2.90980303
122negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90320038
123DNA damage response, detection of DNA damage (GO:0042769)2.90314754
124negative regulation of synaptic transmission, GABAergic (GO:0032229)2.88108917
125auditory behavior (GO:0031223)2.88054749
126growth hormone secretion (GO:0030252)2.86742384
127lysine metabolic process (GO:0006553)2.83370156
128lysine catabolic process (GO:0006554)2.83370156
129digestion (GO:0007586)2.82212295
130purine nucleotide transport (GO:0015865)2.79662380
131aldehyde catabolic process (GO:0046185)2.78969814
132energy coupled proton transport, down electrochemical gradient (GO:0015985)2.78324270
133ATP synthesis coupled proton transport (GO:0015986)2.78324270
134regulation of nuclear cell cycle DNA replication (GO:0033262)2.77774819
135DNA double-strand break processing (GO:0000729)2.77399779
136electron transport chain (GO:0022900)2.77182653
137establishment of viral latency (GO:0019043)2.77165938
138sterol catabolic process (GO:0016127)2.76151827
139cholesterol catabolic process (GO:0006707)2.76151827
140respiratory electron transport chain (GO:0022904)2.75879136
141branched-chain amino acid metabolic process (GO:0009081)2.75248498
142regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.71979787
143nucleobase biosynthetic process (GO:0046112)2.71727581
144excretion (GO:0007588)2.69928412
145regulation of cellular amide metabolic process (GO:0034248)2.69378712
146negative regulation of transcription by competitive promoter binding (GO:0010944)2.69299254
147ethanol oxidation (GO:0006069)2.68024668
148fucose catabolic process (GO:0019317)2.67612490
149L-fucose metabolic process (GO:0042354)2.67612490
150L-fucose catabolic process (GO:0042355)2.67612490
151regulation of interleukin-8 secretion (GO:2000482)2.67476403
152regulation of cholesterol biosynthetic process (GO:0045540)2.67421980
153glutamate metabolic process (GO:0006536)2.66516492
154dicarboxylic acid biosynthetic process (GO:0043650)2.65968309
155single strand break repair (GO:0000012)2.64957893
156valine metabolic process (GO:0006573)2.64957537
157response to gravity (GO:0009629)2.64573688
158G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64528447
159proline metabolic process (GO:0006560)2.64453789
160sperm capacitation (GO:0048240)2.63630083
161fructose metabolic process (GO:0006000)2.63414355
162protein targeting to mitochondrion (GO:0006626)2.62906853
163myelination in peripheral nervous system (GO:0022011)2.62697917
164peripheral nervous system axon ensheathment (GO:0032292)2.62697917
165aspartate family amino acid catabolic process (GO:0009068)2.62152103
166proline transport (GO:0015824)2.62078674
167negative regulation of circadian rhythm (GO:0042754)2.60890527
168L-amino acid transport (GO:0015807)2.60435178
169hydrogen peroxide metabolic process (GO:0042743)2.59971944
170ATP hydrolysis coupled proton transport (GO:0015991)2.59728534
171energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.59728534
172regulation of cardiac muscle cell contraction (GO:0086004)2.59591346
173very long-chain fatty acid metabolic process (GO:0000038)2.58758115
174positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.58017318
175RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.57565289
176tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.57565289
177sodium-independent organic anion transport (GO:0043252)2.57539751
178DNA replication-independent nucleosome organization (GO:0034724)2.57470901
179DNA replication-independent nucleosome assembly (GO:0006336)2.57470901
180regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.57151331
181nephron tubule development (GO:0072080)2.56412815
182cysteine metabolic process (GO:0006534)2.55954191
183epithelial cilium movement (GO:0003351)2.55605833
184reverse cholesterol transport (GO:0043691)2.55352192
185linoleic acid metabolic process (GO:0043651)2.55032701
186positive regulation of response to extracellular stimulus (GO:0032106)2.54746074
187positive regulation of response to nutrient levels (GO:0032109)2.54746074
188aerobic respiration (GO:0009060)2.54397984
189deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.53225359
190response to histamine (GO:0034776)2.53073053
191membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.51549584
192neuroblast proliferation (GO:0007405)2.51522018
193negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.51018461
194negative regulation of ligase activity (GO:0051352)2.51018461
195serotonin receptor signaling pathway (GO:0007210)2.50588198
196response to X-ray (GO:0010165)2.50570598
197RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.49702295
198negative regulation of stress fiber assembly (GO:0051497)2.49382367
199maturation of 5.8S rRNA (GO:0000460)2.48421113
200axonemal dynein complex assembly (GO:0070286)2.47601699

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.35438561
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.18142499
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.44642606
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.16291259
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05392903
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.02000997
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.79933510
8AR_21572438_ChIP-Seq_LNCaP_Human2.79282513
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.78421155
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.67728502
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.64478014
12* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.56071585
13EZH2_22144423_ChIP-Seq_EOC_Human2.52346539
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.50856364
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47504052
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46527325
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44800609
18ZNF274_21170338_ChIP-Seq_K562_Hela2.42496789
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39283779
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39283779
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37400019
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35266664
23GBX2_23144817_ChIP-Seq_PC3_Human2.30300850
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29858468
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28506074
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10940779
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.10100105
28CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08248895
29ELK1_19687146_ChIP-ChIP_HELA_Human2.01800545
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.99484086
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.99228679
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94806966
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.92324531
34VDR_22108803_ChIP-Seq_LS180_Human1.92217865
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87743741
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86233464
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85435402
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.80077918
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.79731881
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79359304
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.79070938
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78021981
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76113203
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.72597347
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72099580
46VDR_23849224_ChIP-Seq_CD4+_Human1.66328257
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63835919
48EWS_26573619_Chip-Seq_HEK293_Human1.61017703
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58682244
50BCAT_22108803_ChIP-Seq_LS180_Human1.57267541
51RXR_22108803_ChIP-Seq_LS180_Human1.56518114
52* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56481743
53E2F7_22180533_ChIP-Seq_HELA_Human1.56060227
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.55685781
55TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.55252058
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.55149865
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54877745
58ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.53426477
59MYC_18555785_ChIP-Seq_MESCs_Mouse1.53219052
60DROSHA_22980978_ChIP-Seq_HELA_Human1.52965021
61FUS_26573619_Chip-Seq_HEK293_Human1.52707011
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.48999053
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48773546
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.48600607
65FOXP3_21729870_ChIP-Seq_TREG_Human1.48572436
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48326042
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46472021
68REST_21632747_ChIP-Seq_MESCs_Mouse1.46340622
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45338614
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43047722
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42224486
72TP53_18474530_ChIP-ChIP_U2OS_Human1.40774893
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40574747
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.38371991
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38091148
76P300_19829295_ChIP-Seq_ESCs_Human1.35956258
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35565927
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35254325
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.34848874
80* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31626608
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31155263
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31041415
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28717487
84NANOG_16153702_ChIP-ChIP_HESCs_Human1.28329310
85AR_25329375_ChIP-Seq_VCAP_Human1.28302652
86* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28242898
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28076512
88SOX2_19829295_ChIP-Seq_ESCs_Human1.27851731
89NANOG_19829295_ChIP-Seq_ESCs_Human1.27851731
90MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26644267
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25124910
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.24653418
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.22272122
94FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17680891
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16909996
96* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16104469
97ESR1_21235772_ChIP-Seq_MCF-7_Human1.15920479
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15022864
99MYC_18940864_ChIP-ChIP_HL60_Human1.14951951
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13823115
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12020423
102IGF1R_20145208_ChIP-Seq_DFB_Human1.11265282
103MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10975135
104STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10938889
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10357923
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10201492
107RBPJ_21746931_ChIP-Seq_IB4_Human1.09948046
108FOXA1_25329375_ChIP-Seq_VCAP_Human1.09759603
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09759603
110SOX2_16153702_ChIP-ChIP_HESCs_Human1.09117121
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08517836
112SMAD4_21799915_ChIP-Seq_A2780_Human1.08506082
113* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07457335
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07437588
115GATA1_26923725_Chip-Seq_HPCs_Mouse1.07386364
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06756633
117NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.06619460
118* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06416261
119* CBP_20019798_ChIP-Seq_JUKART_Human1.06416261
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06213704
121E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05199269
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04733659
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04634056
124AR_20517297_ChIP-Seq_VCAP_Human1.04596631
125ETV1_20927104_ChIP-Seq_GIST48_Human1.04583058
126PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04370523
127AR_21909140_ChIP-Seq_LNCAP_Human1.03596290
128TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03418149
129NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03245050
130ARNT_22903824_ChIP-Seq_MCF-7_Human1.02374191
131CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01631840
132PHF8_20622853_ChIP-Seq_HELA_Human1.01450265
133* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01439774
134MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00967454
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99919322
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99919322
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99488565
138TAF15_26573619_Chip-Seq_HEK293_Human0.99363850
139CDX2_22108803_ChIP-Seq_LS180_Human0.99001918
140FOXH1_21741376_ChIP-Seq_EPCs_Human0.98755976
141CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96661757
142FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96553981
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95850801
144WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95788094
145KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95778354
146REST_18959480_ChIP-ChIP_MESCs_Mouse0.95461969
147YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95425842
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94976762
149TP53_22573176_ChIP-Seq_HFKS_Human0.94957980
150IRF1_19129219_ChIP-ChIP_H3396_Human0.94763483
151TCF4_18268006_ChIP-ChIP_LS174T_Human0.94258098
152P300_18555785_Chip-Seq_ESCs_Mouse0.92971762
153ELK1_22589737_ChIP-Seq_MCF10A_Human0.92704042
154SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92552607
155LXR_22158963_ChIP-Seq_LIVER_Mouse0.91791742
156ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91701726
157GABP_19822575_ChIP-Seq_HepG2_Human0.91513513
158PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91266078
159ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91235284
160CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89833859
161TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89648401
162AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89613576
163SMAD_19615063_ChIP-ChIP_OVARY_Human0.88436549
164AHR_22903824_ChIP-Seq_MCF-7_Human0.88218124
165* AR_19668381_ChIP-Seq_PC3_Human0.87750722
166CLOCK_20551151_ChIP-Seq_293T_Human0.85456534
167SMAD3_21741376_ChIP-Seq_EPCs_Human0.85302414
168RARB_27405468_Chip-Seq_BRAIN_Mouse0.84942604
169PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84867777
170RXR_22158963_ChIP-Seq_LIVER_Mouse0.84565024
171EP300_21415370_ChIP-Seq_HL-1_Mouse0.84149034
172SOX2_21211035_ChIP-Seq_LN229_Gbm0.83469968
173TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82257977
174RING1B_27294783_Chip-Seq_NPCs_Mouse0.81771827
175TP53_16413492_ChIP-PET_HCT116_Human0.81475096
176TCF4_22108803_ChIP-Seq_LS180_Human0.80632094
177HTT_18923047_ChIP-ChIP_STHdh_Human0.80245804
178SMAD3_21741376_ChIP-Seq_HESCs_Human0.79935549
179SMAD4_21741376_ChIP-Seq_HESCs_Human0.79136145
180TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79102002
181RUNX2_22187159_ChIP-Seq_PCA_Human0.79072806
182SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.75870806
183PRDM14_20953172_ChIP-Seq_ESCs_Human0.75638728
184RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74195012
185FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73959633
186NANOG_18555785_Chip-Seq_ESCs_Mouse0.73643062
187LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72332329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder4.44050225
2MP0004043_abnormal_pH_regulation3.97461118
3MP0002138_abnormal_hepatobiliary_system3.96975670
4MP0002254_reproductive_system_inflammat3.77766976
5MP0002132_abnormal_respiratory_system3.64892454
6MP0002277_abnormal_respiratory_mucosa3.57801706
7MP0003300_gastrointestinal_ulcer3.47176687
8MP0003690_abnormal_glial_cell3.47073498
9MP0003329_amyloid_beta_deposits3.27381037
10MP0004885_abnormal_endolymph3.25471583
11MP0005377_hearing/vestibular/ear_phenot3.03311114
12MP0003878_abnormal_ear_physiology3.03311114
13MP0003136_yellow_coat_color3.00045639
14MP0008877_abnormal_DNA_methylation2.87883150
15MP0004858_abnormal_nervous_system2.78452481
16MP0005332_abnormal_amino_acid2.73005961
17MP0005646_abnormal_pituitary_gland2.65041962
18MP0008058_abnormal_DNA_repair2.63805457
19MP0002163_abnormal_gland_morphology2.59928999
20MP0005084_abnormal_gallbladder_morpholo2.59563552
21MP0008872_abnormal_physiological_respon2.49690446
22MP0009384_cardiac_valve_regurgitation2.44185357
23MP0002876_abnormal_thyroid_physiology2.28816708
24MP0000566_synostosis2.23689072
25MP0005220_abnormal_exocrine_pancreas2.15591471
26MP0001486_abnormal_startle_reflex2.14895377
27MP0003075_altered_response_to2.13187883
28MP0003693_abnormal_embryo_hatching2.09460949
29MP0009780_abnormal_chondrocyte_physiolo2.01446526
30MP0003718_maternal_effect1.96831183
31MP0003279_aneurysm1.94946047
32MP0006035_abnormal_mitochondrial_morpho1.93088788
33MP0001502_abnormal_circadian_rhythm1.92890355
34MP0003252_abnormal_bile_duct1.92709218
35MP0002928_abnormal_bile_duct1.91265551
36MP0004957_abnormal_blastocyst_morpholog1.86797890
37MP0004019_abnormal_vitamin_homeostasis1.84495255
38MP0000604_amyloidosis1.82538678
39MP0006036_abnormal_mitochondrial_physio1.76035356
40MP0001485_abnormal_pinna_reflex1.73417620
41MP0005423_abnormal_somatic_nervous1.71352344
42MP0002396_abnormal_hematopoietic_system1.68891812
43MP0001188_hyperpigmentation1.68650430
44MP0003011_delayed_dark_adaptation1.66397152
45MP0010094_abnormal_chromosome_stability1.63731855
46MP0010352_gastrointestinal_tract_polyps1.61445219
47MP0005171_absent_coat_pigmentation1.60820589
48MP0001440_abnormal_grooming_behavior1.60309239
49MP0004859_abnormal_synaptic_plasticity1.58614193
50MP0001984_abnormal_olfaction1.57985642
51MP0003634_abnormal_glial_cell1.51918267
52MP0001765_abnormal_ion_homeostasis1.51122824
53MP0001853_heart_inflammation1.49927394
54MP0003635_abnormal_synaptic_transmissio1.49787042
55MP0002638_abnormal_pupillary_reflex1.48215610
56MP0004270_analgesia1.48145026
57MP0000049_abnormal_middle_ear1.47298152
58MP0003943_abnormal_hepatobiliary_system1.47081919
59MP0003890_abnormal_embryonic-extraembry1.46293403
60MP0003633_abnormal_nervous_system1.39219284
61MP0009745_abnormal_behavioral_response1.37678075
62MP0009840_abnormal_foam_cell1.36740676
63MP0005085_abnormal_gallbladder_physiolo1.36654111
64MP0003724_increased_susceptibility_to1.35613878
65MP0005165_increased_susceptibility_to1.34657436
66MP0009643_abnormal_urine_homeostasis1.34189031
67MP0002064_seizures1.33680953
68MP0005167_abnormal_blood-brain_barrier1.30462941
69MP0001756_abnormal_urination1.29211328
70MP0001958_emphysema1.28984299
71MP0000613_abnormal_salivary_gland1.28276506
72MP0009046_muscle_twitch1.27329567
73MP0004133_heterotaxia1.24935993
74MP0002572_abnormal_emotion/affect_behav1.24490456
75MP0002249_abnormal_larynx_morphology1.20662422
76MP0003631_nervous_system_phenotype1.19381999
77MP0000538_abnormal_urinary_bladder1.19090135
78MP0002089_abnormal_postnatal_growth/wei1.17921792
79MP0002127_abnormal_cardiovascular_syste1.15807360
80MP0003787_abnormal_imprinting1.15255481
81MP0001177_atelectasis1.15050215
82MP0003941_abnormal_skin_development1.15039654
83MP0001664_abnormal_digestion1.13974175
84MP0002063_abnormal_learning/memory/cond1.13874192
85MP0003866_abnormal_defecation1.13858868
86MP0001764_abnormal_homeostasis1.11366444
87MP0000026_abnormal_inner_ear1.09697105
88MP0002139_abnormal_hepatobiliary_system1.09485963
89MP0005360_urolithiasis1.09266279
90MP0005395_other_phenotype1.09237662
91MP0008569_lethality_at_weaning1.09058062
92MP0002736_abnormal_nociception_after1.08065021
93MP0001501_abnormal_sleep_pattern1.07754448
94MP0001963_abnormal_hearing_physiology1.07729172
95MP0003632_abnormal_nervous_system1.07711670
96MP0005551_abnormal_eye_electrophysiolog1.07226778
97MP0003786_premature_aging1.07224893
98MP0004742_abnormal_vestibular_system1.05695151
99MP0006292_abnormal_olfactory_placode1.04983016
100MP0005410_abnormal_fertilization1.04544410
101MP0002557_abnormal_social/conspecific_i1.04497120
102MP0005166_decreased_susceptibility_to1.04158780
103MP0005636_abnormal_mineral_homeostasis1.03139191
104MP0003186_abnormal_redox_activity1.03009522
105MP0006072_abnormal_retinal_apoptosis1.02785326
106MP0002136_abnormal_kidney_physiology1.01698396
107MP0003111_abnormal_nucleus_morphology1.01682066
108MP0008007_abnormal_cellular_replicative0.99628999
109MP0005595_abnormal_vascular_smooth0.98877057
110MP0002733_abnormal_thermal_nociception0.97479975
111MP0010030_abnormal_orbit_morphology0.96834719
112MP0003638_abnormal_response/metabolism_0.95591375
113MP0002067_abnormal_sensory_capabilities0.95285139
114MP0001666_abnormal_nutrient_absorption0.94959398
115MP0005058_abnormal_lysosome_morphology0.93039062
116MP0004215_abnormal_myocardial_fiber0.92931356
117MP0005645_abnormal_hypothalamus_physiol0.90771806
118MP0002295_abnormal_pulmonary_circulatio0.90010067
119MP0003137_abnormal_impulse_conducting0.88582123
120MP0002734_abnormal_mechanical_nocicepti0.88482900
121MP0001905_abnormal_dopamine_level0.88423224
122MP0002090_abnormal_vision0.86719579
123MP0008057_abnormal_DNA_replication0.84845614
124MP0003567_abnormal_fetal_cardiomyocyte0.84446924
125MP0005253_abnormal_eye_physiology0.84342653
126MP0001968_abnormal_touch/_nociception0.83668364
127MP0003806_abnormal_nucleotide_metabolis0.83542008
128MP0005365_abnormal_bile_salt0.82544882
129MP0005535_abnormal_body_temperature0.81175710
130MP0005584_abnormal_enzyme/coenzyme_acti0.80444499
131MP0002272_abnormal_nervous_system0.78074940
132MP0008873_increased_physiological_sensi0.77435541
133MP0003077_abnormal_cell_cycle0.77374132
134MP0001293_anophthalmia0.77356093
135MP0005379_endocrine/exocrine_gland_phen0.75497466
136MP0001929_abnormal_gametogenesis0.75346090
137MP0005319_abnormal_enzyme/_coenzyme0.75230188
138MP0001145_abnormal_male_reproductive0.74773872
139MP0005647_abnormal_sex_gland0.74330707
140MP0000358_abnormal_cell_content/0.73973890
141MP0008875_abnormal_xenobiotic_pharmacok0.73856017
142MP0009764_decreased_sensitivity_to0.72289269
143MP0005083_abnormal_biliary_tract0.71724178
144MP0002735_abnormal_chemical_nociception0.71708754
145MP0002909_abnormal_adrenal_gland0.71528178
146MP0003119_abnormal_digestive_system0.71049552
147MP0000778_abnormal_nervous_system0.70859282
148MP0000653_abnormal_sex_gland0.70569566
149MP0003195_calcinosis0.70566063
150MP0001970_abnormal_pain_threshold0.68969211
151MP0009765_abnormal_xenobiotic_induced0.68777092
152MP0000230_abnormal_systemic_arterial0.66944615
153MP0003183_abnormal_peptide_metabolism0.66895868
154MP0000383_abnormal_hair_follicle0.65733290
155MP0005266_abnormal_metabolism0.64718434
156MP0000462_abnormal_digestive_system0.64066909
157MP0002796_impaired_skin_barrier0.64012671
158MP0004147_increased_porphyrin_level0.63823069
159MP0001545_abnormal_hematopoietic_system0.63428883
160MP0005397_hematopoietic_system_phenotyp0.63428883
161MP0003121_genomic_imprinting0.63358257
162MP0008932_abnormal_embryonic_tissue0.62910400
163MP0002693_abnormal_pancreas_physiology0.61277713
164MP0005075_abnormal_melanosome_morpholog0.59309394
165MP0005376_homeostasis/metabolism_phenot0.57699858
166MP0009703_decreased_birth_body0.57481780

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)6.10046345
2Aplasia involving bones of the extremities (HP:0009825)5.80540955
3Aplasia involving bones of the upper limbs (HP:0009823)5.80540955
4Aplasia of the phalanges of the hand (HP:0009802)5.80540955
5Hypokalemic alkalosis (HP:0001949)5.47674607
6Increased circulating renin level (HP:0000848)5.20567995
7Abnormal urine output (HP:0012590)5.01598999
8Polyuria (HP:0000103)4.91701806
9Abnormality of renal excretion (HP:0011036)4.69096881
10Megalencephaly (HP:0001355)4.68649480
11Hypomagnesemia (HP:0002917)4.35779552
12Abnormal drinking behavior (HP:0030082)4.22030228
13Polydipsia (HP:0001959)4.22030228
14Neurofibrillary tangles (HP:0002185)4.19776143
15Hyperglycinuria (HP:0003108)4.12971738
16Hyperactive renin-angiotensin system (HP:0000841)4.07992824
17Diplopia (HP:0000651)4.04840394
18Abnormality of binocular vision (HP:0011514)4.04840394
19Abnormality of secondary sexual hair (HP:0009888)3.88479332
20Abnormality of the axillary hair (HP:0100134)3.88479332
21Exocrine pancreatic insufficiency (HP:0001738)3.85558383
22Hyperaldosteronism (HP:0000859)3.81411643
23Renal salt wasting (HP:0000127)3.64801151
24Abnormality of serine family amino acid metabolism (HP:0010894)3.61812356
25Abnormality of glycine metabolism (HP:0010895)3.61812356
26Abnormality of magnesium homeostasis (HP:0004921)3.61142310
27Abnormality of chloride homeostasis (HP:0011422)3.59002867
28Hemiparesis (HP:0001269)3.51539347
29Pancreatic cysts (HP:0001737)3.41987875
30Acute necrotizing encephalopathy (HP:0006965)3.30959844
31Azoospermia (HP:0000027)3.28038890
32Male infertility (HP:0003251)3.27943884
33Back pain (HP:0003418)3.27316974
34Hypoplastic left heart (HP:0004383)3.26720566
35Mitochondrial inheritance (HP:0001427)3.24682464
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.18365518
37Gout (HP:0001997)3.16520763
38Potter facies (HP:0002009)3.15586733
39Facial shape deformation (HP:0011334)3.15586733
40Acute encephalopathy (HP:0006846)3.13790469
41Humeroradial synostosis (HP:0003041)3.09300398
42Synostosis involving the elbow (HP:0003938)3.09300398
43Clumsiness (HP:0002312)3.07768831
44Abnormality of renin-angiotensin system (HP:0000847)3.07612970
45Hemiplegia (HP:0002301)3.06149837
46Chronic bronchitis (HP:0004469)3.05517595
47Cerebral inclusion bodies (HP:0100314)3.03485492
48Ileus (HP:0002595)3.00466062
49Ketoacidosis (HP:0001993)2.99103849
50Abnormality of the middle phalanges of the toes (HP:0010183)2.96611434
51Confusion (HP:0001289)2.93262467
52Abnormality of the labia minora (HP:0012880)2.90121317
53Alkalosis (HP:0001948)2.86432301
54Onycholysis (HP:0001806)2.84046478
55Progressive macrocephaly (HP:0004481)2.81792970
56Abnormal mitochondria in muscle tissue (HP:0008316)2.79815681
57Short hallux (HP:0010109)2.77224919
58Abnormal spermatogenesis (HP:0008669)2.77159738
59Lipid accumulation in hepatocytes (HP:0006561)2.75433578
60Increased hepatocellular lipid droplets (HP:0006565)2.73995978
61Tetany (HP:0001281)2.72512926
62Increased CSF lactate (HP:0002490)2.64565096
63Abnormal respiratory motile cilium physiology (HP:0012261)2.62812446
64Hepatocellular necrosis (HP:0001404)2.61893923
65Fibular aplasia (HP:0002990)2.61212886
66Rhinitis (HP:0012384)2.60897805
67True hermaphroditism (HP:0010459)2.60816853
68Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.55665617
69Bronchiectasis (HP:0002110)2.54089603
70Absent hair (HP:0002298)2.51791455
71Abnormal respiratory motile cilium morphology (HP:0005938)2.51664936
72Abnormal respiratory epithelium morphology (HP:0012253)2.51664936
73Hypokalemia (HP:0002900)2.49503842
74Dynein arm defect of respiratory motile cilia (HP:0012255)2.49426812
75Absent/shortened dynein arms (HP:0200106)2.49426812
76Abnormality of macular pigmentation (HP:0008002)2.47885904
77Aplasia/Hypoplasia of the hallux (HP:0008362)2.47635396
78Colon cancer (HP:0003003)2.47293444
79Central scotoma (HP:0000603)2.47006866
80Renal Fanconi syndrome (HP:0001994)2.44222020
81Abnormality of the dental pulp (HP:0006479)2.44125275
82Hypoplastic heart (HP:0001961)2.43883270
83Abnormal ciliary motility (HP:0012262)2.42878488
84Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.42495541
85Scotoma (HP:0000575)2.42138546
86Short middle phalanx of the 5th finger (HP:0004220)2.41790064
87Steatorrhea (HP:0002570)2.41488358
88Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.40361469
89Pancreatic fibrosis (HP:0100732)2.40058550
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.38701279
91Hypoglycemic seizures (HP:0002173)2.37957137
92Methylmalonic aciduria (HP:0012120)2.37034690
93Renal tubular acidosis (HP:0001947)2.35733662
94Hyperglycinemia (HP:0002154)2.31236272
95Abnormality of the renal medulla (HP:0100957)2.30522402
96Type I transferrin isoform profile (HP:0003642)2.29551404
97Abnormality of proline metabolism (HP:0010907)2.28168954
98Hydroxyprolinuria (HP:0003080)2.28168954
99Adactyly (HP:0009776)2.28114189
100Abnormality of serum amino acid levels (HP:0003112)2.26321418
101Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.26052391
102Aplasia/hypoplasia of the uterus (HP:0008684)2.25888225
103Split foot (HP:0001839)2.24738031
104Abolished electroretinogram (ERG) (HP:0000550)2.22177850
105Hepatic necrosis (HP:0002605)2.21993124
106Tubulointerstitial nephritis (HP:0001970)2.21814660
107Symphalangism affecting the phalanges of the hand (HP:0009773)2.20025855
108Cerebral edema (HP:0002181)2.19741134
109Abnormality of permanent molar morphology (HP:0011071)2.18393707
110Abnormality of the dental root (HP:0006486)2.18393707
111Taurodontia (HP:0000679)2.18393707
112Hypoproteinemia (HP:0003075)2.17783687
113Abnormality of methionine metabolism (HP:0010901)2.17366875
114Abnormality of the phalanges of the 5th finger (HP:0004213)2.16071857
115Severe visual impairment (HP:0001141)2.15895885
116Molar tooth sign on MRI (HP:0002419)2.14694423
117Abnormality of midbrain morphology (HP:0002418)2.14694423
118Ketosis (HP:0001946)2.14497584
119Abnormal biliary tract morphology (HP:0012440)2.13604794
120Glycosuria (HP:0003076)2.13229145
121Abnormality of urine glucose concentration (HP:0011016)2.13229145
122Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13005486
123Abnormality of molar (HP:0011077)2.10023826
124Abnormality of molar morphology (HP:0011070)2.10023826
125Status epilepticus (HP:0002133)2.09466969
126Cystic liver disease (HP:0006706)2.08254735
127Long nose (HP:0003189)2.07371881
128Mixed hearing impairment (HP:0000410)2.06171492
129Abnormality of renal resorption (HP:0011038)2.05262444
130Hypoplasia of the uterus (HP:0000013)2.05215338
131Megaloblastic anemia (HP:0001889)2.05213737
132Rectal prolapse (HP:0002035)2.05012554
133Neonatal short-limb short stature (HP:0008921)2.01220157
134Bilateral sensorineural hearing impairment (HP:0008619)1.98720485
135Pseudobulbar signs (HP:0002200)1.98434823
136Nephronophthisis (HP:0000090)1.98027530
137Respiratory failure (HP:0002878)1.96137652
138Lactic acidosis (HP:0003128)1.95369516
139Abnormal pancreas size (HP:0012094)1.94595585
140Hyperinsulinemic hypoglycemia (HP:0000825)1.93347187
141Sensorimotor neuropathy (HP:0007141)1.93274524
142Optic disc pallor (HP:0000543)1.92697631
143Abnormality of potassium homeostasis (HP:0011042)1.91631981
144Decreased central vision (HP:0007663)1.91002707
145Leukodystrophy (HP:0002415)1.90411435
146Renal tubular dysfunction (HP:0000124)1.90322282
147Paraparesis (HP:0002385)1.89946695
148Medial flaring of the eyebrow (HP:0010747)1.89894124
149Abnormal rod and cone electroretinograms (HP:0008323)1.89687956
150Abnormality of vitamin B metabolism (HP:0004340)1.89534695
151Increased purine levels (HP:0004368)1.88478898
152Hyperuricemia (HP:0002149)1.88478898
153Tetraparesis (HP:0002273)1.88177694
154Amyloidosis (HP:0011034)1.88055023
155Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87790221
156Reduced antithrombin III activity (HP:0001976)1.87789315
157Abnormality of the vitamin B12 metabolism (HP:0004341)1.87733470
158Proximal tubulopathy (HP:0000114)1.87327896
159Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.86389477
160Decreased activity of mitochondrial respiratory chain (HP:0008972)1.86389477
161Delayed CNS myelination (HP:0002188)1.84162765
162Tubulointerstitial fibrosis (HP:0005576)1.84074474
163Abnormality of the renal cortex (HP:0011035)1.83621651
164Septo-optic dysplasia (HP:0100842)1.82880652
165Lethargy (HP:0001254)1.82067470
166Hypercalciuria (HP:0002150)1.81605897
167Enlarged kidneys (HP:0000105)1.81280001
168Abnormality of glutamine family amino acid metabolism (HP:0010902)1.78619751
169Hyperventilation (HP:0002883)1.75526528
170Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74769593
171Abnormality of fatty-acid metabolism (HP:0004359)1.74643053
172Maternal diabetes (HP:0009800)1.74217954
173Spastic paraparesis (HP:0002313)1.73653453
174Abnormality of sodium homeostasis (HP:0010931)1.73160393
175Epileptic encephalopathy (HP:0200134)1.69620646
176Methylmalonic acidemia (HP:0002912)1.66636331
177Tubular atrophy (HP:0000092)1.65826263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.58391923
2LMTK24.35128158
3WNK34.27550716
4OXSR13.43641378
5PHKG23.20868095
6PHKG13.20868095
7VRK23.14865563
8TNIK3.02972752
9MUSK2.95450697
10PRKD32.94278101
11WNK42.88529925
12NTRK22.62548418
13BCKDK2.20397298
14NUAK12.11285213
15CASK2.06435640
16BMPR1B2.05677195
17STK242.05518086
18PRKG22.02787234
19SGK21.97804240
20MST41.94394601
21NME11.92154915
22SIK11.88722101
23MAP3K121.86555624
24SGK2231.85640319
25SGK4941.85640319
26ZAK1.73685669
27FRK1.69959079
28MAPK121.69835333
29MKNK21.69295948
30TRIB31.62014495
31SGK31.57798916
32SRPK11.53875849
33STK391.50436539
34PDK41.45154432
35PDK31.45154432
36STK161.39481543
37IRAK31.37869532
38PLK31.36340214
39TTK1.35903034
40BUB11.31035462
41MKNK11.30775714
42GRK11.29983000
43MAPK131.25365640
44VRK11.25322324
45NLK1.24692954
46CDK191.24131863
47PRKD21.19596049
48NTRK31.16386885
49TSSK61.15965850
50GRK61.15366876
51EIF2AK31.14610507
52INSRR1.10916154
53TNK21.09086131
54CDC71.06025408
55MAP4K21.04949910
56PDK21.00433205
57TAOK30.99438952
58ADRBK10.97276020
59FLT30.94080919
60DYRK20.93343974
61PRKCE0.93241992
62PBK0.90354098
63BRSK20.90060427
64PINK10.87515367
65ACVR1B0.85743188
66PLK10.84649953
67TRIM280.83230752
68PRKCG0.81451621
69MAP2K70.79206962
70DAPK10.78089291
71PRKCH0.76995654
72FGR0.74531029
73PLK40.74400762
74MAP3K70.73417314
75CSNK1G10.71952069
76DAPK20.70834188
77EIF2AK10.70027635
78PIK3CA0.68584595
79TIE10.67176001
80NEK10.66979280
81MAPK70.66150425
82SGK10.65985984
83MINK10.65335779
84STK380.65030253
85PASK0.63992307
86STK30.62769796
87CDK50.62189880
88TAOK20.61713515
89WNK10.59880001
90NEK60.58848704
91IGF1R0.58283527
92CAMK2A0.55122142
93ERN10.54795847
94ROCK10.54608880
95STK38L0.53984805
96PRKCA0.52774177
97CSNK1G20.52766719
98PRKACA0.52494606
99SIK30.52129721
100GRK70.51660628
101PLK20.50123486
102MAP3K40.50118757
103CSNK1G30.48636966
104DYRK1A0.47851420
105SIK20.46956364
106CDK30.46911881
107PRKCQ0.46666401
108TAF10.45773247
109PRKACG0.45579667
110TEC0.45025195
111PAK30.43819456
112FGFR20.43761987
113NTRK10.42798945
114STK40.42468225
115RPS6KB20.42131110
116PRKAA20.41410648
117ALK0.41275353
118DDR20.40590415
119CHEK20.40390339
120CSNK1A10.40220702
121ATM0.39620540
122CSNK2A10.38484701
123ERBB30.37843094
124PNCK0.37402316
125NME20.37057655
126MAPK110.37016377
127ATR0.36471710
128FGFR10.36259604
129EIF2AK20.36082090
130ROCK20.35415372
131PRPF4B0.35215443
132PDPK10.34253861
133MARK10.33757230
134CSNK2A20.33633699
135BMX0.33545829
136ADRBK20.33403278
137CSNK1A1L0.33259777
138DYRK30.33218672
139MELK0.32588043
140SRC0.31775844
141EPHA20.31668092
142FER0.31496528
143STK100.30356369
144PRKAA10.30240989
145PRKG10.29867058
146RPS6KA30.29798232
147GRK50.29404150
148CDK80.29233999
149CAMK1D0.29111346
150MARK30.28094006
151ILK0.27699904
152PRKCZ0.27430745
153YES10.27356911
154MST1R0.26438796
155CAMK1G0.25933883
156MAPK40.25701742
157DMPK0.25258223
158AURKB0.25249802
159PRKACB0.24152907
160CSNK1E0.24117573
161PTK2B0.23422605
162AKT20.23133027
163MATK0.22438183
164PTK60.21862855
165TGFBR10.21757808
166PIK3CG0.21483910
167EGFR0.21376088
168LRRK20.21251712
169MYLK0.21242153
170CDC42BPA0.20323488
171CAMK2G0.20177683
172PRKDC0.19409948

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.01010603
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049644.39212464
3Fatty acid biosynthesis_Homo sapiens_hsa000614.11595606
4Proteasome_Homo sapiens_hsa030503.37992897
5Fatty acid degradation_Homo sapiens_hsa000712.97079167
6Fatty acid metabolism_Homo sapiens_hsa012122.78084724
7Mismatch repair_Homo sapiens_hsa034302.61480615
8Homologous recombination_Homo sapiens_hsa034402.60524274
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50900773
10Propanoate metabolism_Homo sapiens_hsa006402.46564684
11RNA polymerase_Homo sapiens_hsa030202.45117158
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32781196
13Non-homologous end-joining_Homo sapiens_hsa034502.31587859
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.17325523
15Parkinsons disease_Homo sapiens_hsa050122.16738373
16DNA replication_Homo sapiens_hsa030302.04060575
17Protein export_Homo sapiens_hsa030602.03754278
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.97229868
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81417437
20Sulfur metabolism_Homo sapiens_hsa009201.76094534
21Base excision repair_Homo sapiens_hsa034101.75629964
22Basal transcription factors_Homo sapiens_hsa030221.75622312
23Steroid biosynthesis_Homo sapiens_hsa001001.74902782
24Huntingtons disease_Homo sapiens_hsa050161.71674596
25Peroxisome_Homo sapiens_hsa041461.68416201
26RNA degradation_Homo sapiens_hsa030181.64044054
27Butanoate metabolism_Homo sapiens_hsa006501.63697526
28Bile secretion_Homo sapiens_hsa049761.62315225
29Nicotine addiction_Homo sapiens_hsa050331.55018668
30One carbon pool by folate_Homo sapiens_hsa006701.52496093
31Vitamin digestion and absorption_Homo sapiens_hsa049771.52408951
32PPAR signaling pathway_Homo sapiens_hsa033201.52380358
33Pancreatic secretion_Homo sapiens_hsa049721.50885044
34Ribosome_Homo sapiens_hsa030101.45877639
35Mineral absorption_Homo sapiens_hsa049781.44900744
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.42458048
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41865803
38Salivary secretion_Homo sapiens_hsa049701.40881499
39Vitamin B6 metabolism_Homo sapiens_hsa007501.39723636
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37759885
41Arginine and proline metabolism_Homo sapiens_hsa003301.37305320
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30644528
43Gastric acid secretion_Homo sapiens_hsa049711.30626292
44Glycerolipid metabolism_Homo sapiens_hsa005611.29951023
45RNA transport_Homo sapiens_hsa030131.29947302
46Fanconi anemia pathway_Homo sapiens_hsa034601.29920127
47Pyruvate metabolism_Homo sapiens_hsa006201.29067678
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27900212
49Fatty acid elongation_Homo sapiens_hsa000621.27113494
50GABAergic synapse_Homo sapiens_hsa047271.21085326
51Spliceosome_Homo sapiens_hsa030401.20299044
52Retinol metabolism_Homo sapiens_hsa008301.17406472
53Nucleotide excision repair_Homo sapiens_hsa034201.15171318
54Folate biosynthesis_Homo sapiens_hsa007901.13628520
55Fructose and mannose metabolism_Homo sapiens_hsa000511.10102772
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09569855
57Glutamatergic synapse_Homo sapiens_hsa047241.08831208
58Vibrio cholerae infection_Homo sapiens_hsa051101.05086419
59beta-Alanine metabolism_Homo sapiens_hsa004101.04659438
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04225000
61Pyrimidine metabolism_Homo sapiens_hsa002401.02462508
62Phenylalanine metabolism_Homo sapiens_hsa003601.00954292
63Purine metabolism_Homo sapiens_hsa002301.00658413
64Protein digestion and absorption_Homo sapiens_hsa049741.00291166
65Insulin secretion_Homo sapiens_hsa049110.99472500
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96616993
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96417126
68Arachidonic acid metabolism_Homo sapiens_hsa005900.95460914
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94330150
70Carbon metabolism_Homo sapiens_hsa012000.93354732
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92394803
72Phototransduction_Homo sapiens_hsa047440.90698341
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90399508
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88846484
75Selenocompound metabolism_Homo sapiens_hsa004500.87269476
76Tryptophan metabolism_Homo sapiens_hsa003800.86415717
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85503515
78Histidine metabolism_Homo sapiens_hsa003400.82634983
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81869588
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.80268169
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79294090
82Tyrosine metabolism_Homo sapiens_hsa003500.78811932
83Biosynthesis of amino acids_Homo sapiens_hsa012300.78659728
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78284833
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77783113
86Glutathione metabolism_Homo sapiens_hsa004800.77369976
87Caffeine metabolism_Homo sapiens_hsa002320.76896312
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76634060
89Cocaine addiction_Homo sapiens_hsa050300.76358911
90Thyroid hormone synthesis_Homo sapiens_hsa049180.74250928
91Arginine biosynthesis_Homo sapiens_hsa002200.72924492
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72217981
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70210691
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70109808
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69530573
96Morphine addiction_Homo sapiens_hsa050320.69158587
97Sulfur relay system_Homo sapiens_hsa041220.68938445
98Linoleic acid metabolism_Homo sapiens_hsa005910.68770707
99Circadian rhythm_Homo sapiens_hsa047100.68440064
100Chemical carcinogenesis_Homo sapiens_hsa052040.67117363
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67068190
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.66149879
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65582057
104Renin-angiotensin system_Homo sapiens_hsa046140.64506359
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63776698
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63159450
107Calcium signaling pathway_Homo sapiens_hsa040200.63055832
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62265878
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61315045
110Ether lipid metabolism_Homo sapiens_hsa005650.60771615
111Regulation of autophagy_Homo sapiens_hsa041400.59671413
112Sphingolipid metabolism_Homo sapiens_hsa006000.58915778
113Other glycan degradation_Homo sapiens_hsa005110.58432173
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.55816726
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54491546
116Pentose phosphate pathway_Homo sapiens_hsa000300.53971169
117Lysosome_Homo sapiens_hsa041420.53961258
118Starch and sucrose metabolism_Homo sapiens_hsa005000.53054458
119Oxidative phosphorylation_Homo sapiens_hsa001900.52539527
120Cardiac muscle contraction_Homo sapiens_hsa042600.52242825
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.51904531
122Basal cell carcinoma_Homo sapiens_hsa052170.50897051
123Circadian entrainment_Homo sapiens_hsa047130.50735386
124Renin secretion_Homo sapiens_hsa049240.48993738
125Fat digestion and absorption_Homo sapiens_hsa049750.48439440
126Collecting duct acid secretion_Homo sapiens_hsa049660.46495457
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46210497
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.45768043
129* Tight junction_Homo sapiens_hsa045300.44684303
130* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44682606
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44584041
132Metabolic pathways_Homo sapiens_hsa011000.44441588
133Rheumatoid arthritis_Homo sapiens_hsa053230.44325149
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44183720
135cAMP signaling pathway_Homo sapiens_hsa040240.44029025
136mRNA surveillance pathway_Homo sapiens_hsa030150.41869416
137Olfactory transduction_Homo sapiens_hsa047400.41767148
138Taste transduction_Homo sapiens_hsa047420.41361090
139Alzheimers disease_Homo sapiens_hsa050100.38585988
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.38500624
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38181022
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38172491
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38110114
144Dorso-ventral axis formation_Homo sapiens_hsa043200.36369177
145Melanogenesis_Homo sapiens_hsa049160.35395016
146Galactose metabolism_Homo sapiens_hsa000520.35301412
147Glycosaminoglycan degradation_Homo sapiens_hsa005310.34878263
148Cysteine and methionine metabolism_Homo sapiens_hsa002700.31584918
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.31570146
150African trypanosomiasis_Homo sapiens_hsa051430.31061714
151Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30558701

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