Rank | Gene Set | Z-score |
---|---|---|
1 | exogenous drug catabolic process (GO:0042738) | 7.11981004 |
2 | drug catabolic process (GO:0042737) | 7.05951766 |
3 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 6.92464539 |
4 | L-phenylalanine catabolic process (GO:0006559) | 6.92464539 |
5 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 6.60285920 |
6 | L-phenylalanine metabolic process (GO:0006558) | 6.60285920 |
7 | omega-hydroxylase P450 pathway (GO:0097267) | 6.48189905 |
8 | fatty acid elongation (GO:0030497) | 6.01175382 |
9 | coenzyme catabolic process (GO:0009109) | 5.87989269 |
10 | axon ensheathment in central nervous system (GO:0032291) | 5.82479689 |
11 | central nervous system myelination (GO:0022010) | 5.82479689 |
12 | regulation of plasminogen activation (GO:0010755) | 5.60723905 |
13 | aromatic amino acid family catabolic process (GO:0009074) | 5.58431349 |
14 | heme transport (GO:0015886) | 5.48756235 |
15 | blood coagulation, intrinsic pathway (GO:0007597) | 5.18868609 |
16 | imidazole-containing compound metabolic process (GO:0052803) | 4.95067199 |
17 | glyoxylate metabolic process (GO:0046487) | 4.94163975 |
18 | negative regulation of blood coagulation (GO:0030195) | 4.88977361 |
19 | negative regulation of hemostasis (GO:1900047) | 4.88977361 |
20 | sulfur amino acid catabolic process (GO:0000098) | 4.82762732 |
21 | bile acid biosynthetic process (GO:0006699) | 4.73280565 |
22 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 4.71139291 |
23 | positive regulation of hemostasis (GO:1900048) | 4.67207752 |
24 | positive regulation of blood coagulation (GO:0030194) | 4.67207752 |
25 | negative regulation of coagulation (GO:0050819) | 4.62152796 |
26 | protein activation cascade (GO:0072376) | 4.55697097 |
27 | cofactor catabolic process (GO:0051187) | 4.50688361 |
28 | S-adenosylmethionine metabolic process (GO:0046500) | 4.50625119 |
29 | alpha-linolenic acid metabolic process (GO:0036109) | 4.47864797 |
30 | positive regulation of fatty acid biosynthetic process (GO:0045723) | 4.43677691 |
31 | cellular modified amino acid catabolic process (GO:0042219) | 4.38101772 |
32 | indole-containing compound catabolic process (GO:0042436) | 4.37870194 |
33 | indolalkylamine catabolic process (GO:0046218) | 4.37870194 |
34 | tryptophan catabolic process (GO:0006569) | 4.37870194 |
35 | negative regulation of fibrinolysis (GO:0051918) | 4.36936332 |
36 | oxidative demethylation (GO:0070989) | 4.32416090 |
37 | positive regulation of coagulation (GO:0050820) | 4.30678559 |
38 | phenylpropanoid metabolic process (GO:0009698) | 4.29109508 |
39 | negative regulation of wound healing (GO:0061045) | 4.27176609 |
40 | cholesterol biosynthetic process (GO:0006695) | 4.26712090 |
41 | acute-phase response (GO:0006953) | 4.22479008 |
42 | regulation of fibrinolysis (GO:0051917) | 4.21404706 |
43 | complement activation, classical pathway (GO:0006958) | 4.19083373 |
44 | kynurenine metabolic process (GO:0070189) | 4.17809065 |
45 | complement activation (GO:0006956) | 4.14016230 |
46 | high-density lipoprotein particle remodeling (GO:0034375) | 4.09863530 |
47 | regulation of humoral immune response (GO:0002920) | 4.06694691 |
48 | alkaloid metabolic process (GO:0009820) | 4.05988317 |
49 | tryptophan metabolic process (GO:0006568) | 4.05801056 |
50 | bile acid metabolic process (GO:0008206) | 4.04940439 |
51 | ethanol metabolic process (GO:0006067) | 4.04720504 |
52 | iron coordination entity transport (GO:1901678) | 4.02654014 |
53 | very long-chain fatty acid metabolic process (GO:0000038) | 4.01172257 |
54 | aromatic amino acid family metabolic process (GO:0009072) | 3.99332288 |
55 | protein carboxylation (GO:0018214) | 3.96626761 |
56 | peptidyl-glutamic acid carboxylation (GO:0017187) | 3.96626761 |
57 | regulation of protein activation cascade (GO:2000257) | 3.96406818 |
58 | tyrosine metabolic process (GO:0006570) | 3.91594964 |
59 | ensheathment of neurons (GO:0007272) | 3.87073031 |
60 | axon ensheathment (GO:0008366) | 3.87073031 |
61 | complement activation, alternative pathway (GO:0006957) | 3.86606782 |
62 | plasma lipoprotein particle clearance (GO:0034381) | 3.84945472 |
63 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.83200658 |
64 | plasma lipoprotein particle organization (GO:0071827) | 3.82706842 |
65 | cellular glucuronidation (GO:0052695) | 3.81467674 |
66 | myelination (GO:0042552) | 3.77547395 |
67 | arginine catabolic process (GO:0006527) | 3.77454889 |
68 | cysteine metabolic process (GO:0006534) | 3.76523689 |
69 | regulation of cholesterol esterification (GO:0010872) | 3.76052754 |
70 | urea metabolic process (GO:0019627) | 3.72689495 |
71 | urea cycle (GO:0000050) | 3.72689495 |
72 | arginine metabolic process (GO:0006525) | 3.72583741 |
73 | fatty-acyl-CoA biosynthetic process (GO:0046949) | 3.71302249 |
74 | regulation of apoptotic cell clearance (GO:2000425) | 3.71273888 |
75 | long-chain fatty-acyl-CoA biosynthetic process (GO:0035338) | 3.69509810 |
76 | sterol biosynthetic process (GO:0016126) | 3.67782371 |
77 | plasma lipoprotein particle assembly (GO:0034377) | 3.66566938 |
78 | negative regulation of lipid transport (GO:0032369) | 3.64342842 |
79 | regulation of triglyceride catabolic process (GO:0010896) | 3.64197601 |
80 | glucuronate metabolic process (GO:0019585) | 3.62635981 |
81 | uronic acid metabolic process (GO:0006063) | 3.62635981 |
82 | triglyceride homeostasis (GO:0070328) | 3.62020225 |
83 | acylglycerol homeostasis (GO:0055090) | 3.62020225 |
84 | epoxygenase P450 pathway (GO:0019373) | 3.61423672 |
85 | regulation of complement activation (GO:0030449) | 3.59923447 |
86 | lipoprotein metabolic process (GO:0042157) | 3.59257379 |
87 | alpha-amino acid catabolic process (GO:1901606) | 3.58510070 |
88 | protein-lipid complex subunit organization (GO:0071825) | 3.58033621 |
89 | response to dietary excess (GO:0002021) | 3.53390689 |
90 | flavonoid metabolic process (GO:0009812) | 3.53333530 |
91 | nitrogen cycle metabolic process (GO:0071941) | 3.51204461 |
92 | primary alcohol catabolic process (GO:0034310) | 3.51027991 |
93 | cellular amino acid catabolic process (GO:0009063) | 3.49260927 |
94 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 3.49108230 |
95 | reverse cholesterol transport (GO:0043691) | 3.47956649 |
96 | cholesterol efflux (GO:0033344) | 3.44365690 |
97 | cellular ketone body metabolic process (GO:0046950) | 3.43760637 |
98 | macromolecular complex remodeling (GO:0034367) | 3.42921050 |
99 | plasma lipoprotein particle remodeling (GO:0034369) | 3.42921050 |
100 | protein-lipid complex remodeling (GO:0034368) | 3.42921050 |
101 | negative regulation of protein activation cascade (GO:2000258) | 3.42007674 |
102 | acute inflammatory response (GO:0002526) | 3.41163117 |
103 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.40876980 |
104 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.40876980 |
105 | intestinal cholesterol absorption (GO:0030299) | 3.40715684 |
106 | serine family amino acid catabolic process (GO:0009071) | 3.39129484 |
107 | amino-acid betaine metabolic process (GO:0006577) | 3.38614431 |
108 | myelin maintenance (GO:0043217) | 3.38351701 |
109 | negative regulation of fatty acid biosynthetic process (GO:0045717) | 3.37444410 |
110 | acetyl-CoA metabolic process (GO:0006084) | 3.36463441 |
111 | opsonization (GO:0008228) | 3.35890933 |
112 | serine family amino acid biosynthetic process (GO:0009070) | 3.35349536 |
113 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 3.35261206 |
114 | creatine metabolic process (GO:0006600) | 3.35135063 |
115 | cytolysis (GO:0019835) | 3.34070976 |
116 | low-density lipoprotein particle remodeling (GO:0034374) | 3.34064496 |
117 | L-serine metabolic process (GO:0006563) | 3.33717037 |
118 | drug metabolic process (GO:0017144) | 3.33626487 |
119 | aldehyde catabolic process (GO:0046185) | 3.32348615 |
120 | regulation of lipoprotein particle clearance (GO:0010984) | 3.31096475 |
121 | glycine metabolic process (GO:0006544) | 3.30928096 |
122 | fatty-acyl-CoA metabolic process (GO:0035337) | 3.30643154 |
123 | regulation of bile acid biosynthetic process (GO:0070857) | 3.25137535 |
124 | response to methylmercury (GO:0051597) | 3.24663360 |
125 | amine catabolic process (GO:0009310) | 3.23937449 |
126 | cellular biogenic amine catabolic process (GO:0042402) | 3.23937449 |
127 | cholesterol metabolic process (GO:0008203) | 3.20676255 |
128 | daunorubicin metabolic process (GO:0044597) | 3.20346669 |
129 | polyketide metabolic process (GO:0030638) | 3.20346669 |
130 | doxorubicin metabolic process (GO:0044598) | 3.20346669 |
131 | cholesterol homeostasis (GO:0042632) | 3.19976971 |
132 | phospholipid efflux (GO:0033700) | 3.19934902 |
133 | thioester biosynthetic process (GO:0035384) | 3.19746740 |
134 | acyl-CoA biosynthetic process (GO:0071616) | 3.19746740 |
135 | cofactor transport (GO:0051181) | 3.19693433 |
136 | negative regulation of sterol transport (GO:0032372) | 3.18362993 |
137 | negative regulation of cholesterol transport (GO:0032375) | 3.18362993 |
138 | long-chain fatty-acyl-CoA metabolic process (GO:0035336) | 3.13628933 |
139 | fibrinolysis (GO:0042730) | 3.12153469 |
140 | sterol homeostasis (GO:0055092) | 3.12038309 |
141 | glutamate metabolic process (GO:0006536) | 3.11379034 |
142 | regulation of cholesterol metabolic process (GO:0090181) | 3.09980163 |
143 | negative regulation of lipase activity (GO:0060192) | 3.08464733 |
144 | biotin metabolic process (GO:0006768) | 3.08322274 |
145 | ethanol oxidation (GO:0006069) | 3.08063599 |
146 | hormone catabolic process (GO:0042447) | 3.07258960 |
147 | peroxisome fission (GO:0016559) | 3.06245453 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 8.00868354 |
2 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 5.68737031 |
3 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 4.68280477 |
4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 4.65311169 |
5 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 4.61717561 |
6 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 3.99312929 |
7 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 3.92811829 |
8 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 3.92811829 |
9 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 3.92811829 |
10 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.32654118 |
11 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.22711548 |
12 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 3.20881138 |
13 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.14157640 |
14 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.95709618 |
15 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.55771521 |
16 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.50822442 |
17 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.37124636 |
18 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.98650699 |
19 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.95355914 |
20 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.70230285 |
21 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.53332969 |
22 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.52649988 |
23 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.49291359 |
24 | * GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.47860277 |
25 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.39939540 |
26 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.39365873 |
27 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.36791617 |
28 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.35402211 |
29 | * FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.33801855 |
30 | * SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.33616888 |
31 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.33498492 |
32 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.32602395 |
33 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.26952073 |
34 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.25140792 |
35 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.22029020 |
36 | * GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.20920453 |
37 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.19203209 |
38 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.17069368 |
39 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.14690567 |
40 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.13719866 |
41 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.11797315 |
42 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.11492887 |
43 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.10168374 |
44 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.08479790 |
45 | EOMES_21245162_ChIP-Seq_HESCs_Human | 1.07345169 |
46 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.06331017 |
47 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.06032132 |
48 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.05948753 |
49 | * PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.04765263 |
50 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.04540760 |
51 | AR_20517297_ChIP-Seq_VCAP_Human | 1.01836153 |
52 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.00971452 |
53 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.00697793 |
54 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 1.00097210 |
55 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.99908669 |
56 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.98896138 |
57 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.98497926 |
58 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.97987263 |
59 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 0.97941791 |
60 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.97421870 |
61 | * RXRA_24833708_ChIP-Seq_LIVER_Mouse | 0.96569390 |
62 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.95998117 |
63 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.95856583 |
64 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.95839353 |
65 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.95336384 |
66 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.95019862 |
67 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.94968813 |
68 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.94687294 |
69 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.93298217 |
70 | * RAC3_21632823_ChIP-Seq_H3396_Human | 0.92404009 |
71 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.92282357 |
72 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 0.91620794 |
73 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.91284959 |
74 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.91264052 |
75 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 0.90693417 |
76 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.90639516 |
77 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 0.90025953 |
78 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 0.88934951 |
79 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.88497535 |
80 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.87892768 |
81 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.87322579 |
82 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.86574986 |
83 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 0.85750492 |
84 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.82652946 |
85 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.82502649 |
86 | * SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.81613272 |
87 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.81354009 |
88 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.81106297 |
89 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.81060659 |
90 | NANOG_18692474_ChIP-Seq_MESCs_Mouse | 0.80844842 |
91 | NANOG_18692474_ChIP-Seq_MEFs_Mouse | 0.78652799 |
92 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.78258072 |
93 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.77628902 |
94 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.77599237 |
95 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 0.77576554 |
96 | VDR_22108803_ChIP-Seq_LS180_Human | 0.76012725 |
97 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.73075791 |
98 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.72704376 |
99 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 0.71848977 |
100 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 0.71848977 |
101 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.71143998 |
102 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.71085070 |
103 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.71028310 |
104 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.70920863 |
105 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.70663084 |
106 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.70059279 |
107 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.69960315 |
108 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 0.69835347 |
109 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.69781334 |
110 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.69781334 |
111 | * RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.69569279 |
112 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.69029958 |
113 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.68573753 |
114 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.68474041 |
115 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 0.68417033 |
116 | * NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 0.68232189 |
117 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.68027118 |
118 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.67953650 |
119 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.67497576 |
120 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.67134395 |
121 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.67134395 |
122 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.66828631 |
123 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 0.66450710 |
124 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 0.66404928 |
125 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.66387930 |
126 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.66334339 |
127 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.66334339 |
128 | CJUN_26792858_Chip-Seq_BT549_Human | 0.66324756 |
129 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 0.65968880 |
130 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.65872484 |
131 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.65397730 |
132 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 0.65253699 |
133 | * SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.65144889 |
134 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.65144697 |
135 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.64990745 |
136 | P300_27268052_Chip-Seq_Bcells_Human | 0.64936429 |
137 | ERA_21632823_ChIP-Seq_H3396_Human | 0.64904427 |
138 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.64262361 |
139 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.63778776 |
140 | * E2F1_20622854_ChIP-Seq_HELA_Human | 0.63677653 |
141 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.63154732 |
142 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.62555528 |
143 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.62290385 |
144 | * AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.62222275 |
145 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.62103665 |
146 | LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.61856887 |
147 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.61041660 |
148 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.60959243 |
149 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.60752070 |
150 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.60750170 |
151 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 0.60693240 |
152 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.60591315 |
153 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.59794482 |
154 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.59672283 |
155 | * TCF3_18347094_ChIP-ChIP_MESCs_Mouse | 0.59327161 |
156 | NCOR_22424771_ChIP-Seq_293T_Human | 0.58902126 |
157 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.58651338 |
158 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.58635530 |
159 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 0.58546244 |
160 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.57811735 |
161 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.57289177 |
162 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.57243785 |
163 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.57173170 |
164 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.56701837 |
165 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.56641085 |
166 | SETDB1_19884257_ChIP-Seq_MESCs_Mouse | 0.55923840 |
167 | * E2F1_17053090_ChIP-ChIP_MCF-7_Human | 0.55737650 |
168 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.55560788 |
169 | POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 0.54899718 |
170 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.54881315 |
171 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.53914459 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 6.26404561 |
2 | MP0005360_urolithiasis | 5.58676559 |
3 | MP0005085_abnormal_gallbladder_physiolo | 4.82517005 |
4 | MP0005365_abnormal_bile_salt | 4.41109588 |
5 | MP0008875_abnormal_xenobiotic_pharmacok | 4.32310885 |
6 | MP0003806_abnormal_nucleotide_metabolis | 4.28029990 |
7 | MP0003011_delayed_dark_adaptation | 3.69359293 |
8 | MP0009840_abnormal_foam_cell | 3.07873577 |
9 | MP0000920_abnormal_myelination | 3.06304919 |
10 | MP0003195_calcinosis | 2.81674600 |
11 | MP0003252_abnormal_bile_duct | 2.61170891 |
12 | MP0005083_abnormal_biliary_tract | 2.49180245 |
13 | MP0010329_abnormal_lipoprotein_level | 2.45806914 |
14 | MP0005451_abnormal_body_composition | 2.45684535 |
15 | MP0003690_abnormal_glial_cell | 2.26269381 |
16 | MP0005332_abnormal_amino_acid | 2.21969142 |
17 | MP0002254_reproductive_system_inflammat | 2.17958588 |
18 | MP0001666_abnormal_nutrient_absorption | 1.90011890 |
19 | MP0003191_abnormal_cellular_cholesterol | 1.84033992 |
20 | MP0002118_abnormal_lipid_homeostasis | 1.81404238 |
21 | MP0004381_abnormal_hair_follicle | 1.76552630 |
22 | MP0003329_amyloid_beta_deposits | 1.74431829 |
23 | MP0003950_abnormal_plasma_membrane | 1.70770179 |
24 | MP0000609_abnormal_liver_physiology | 1.55088012 |
25 | MP0000372_irregular_coat_pigmentation | 1.54113764 |
26 | MP0002876_abnormal_thyroid_physiology | 1.51459519 |
27 | MP0006082_CNS_inflammation | 1.51363416 |
28 | MP0005464_abnormal_platelet_physiology | 1.49247459 |
29 | MP0002132_abnormal_respiratory_system | 1.43859365 |
30 | MP0000604_amyloidosis | 1.43752991 |
31 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.42692293 |
32 | MP0005058_abnormal_lysosome_morphology | 1.41346338 |
33 | MP0009785_altered_susceptibility_to | 1.40716715 |
34 | MP0000685_abnormal_immune_system | 1.38680385 |
35 | MP0004264_abnormal_extraembryonic_tissu | 1.37157105 |
36 | MP0004019_abnormal_vitamin_homeostasis | 1.36947384 |
37 | MP0005075_abnormal_melanosome_morpholog | 1.36811439 |
38 | MP0009764_decreased_sensitivity_to | 1.36720836 |
39 | MP0004043_abnormal_pH_regulation | 1.36152411 |
40 | MP0003868_abnormal_feces_composition | 1.31490845 |
41 | MP0004885_abnormal_endolymph | 1.30047665 |
42 | MP0005319_abnormal_enzyme/_coenzyme | 1.28250874 |
43 | MP0004142_abnormal_muscle_tone | 1.24896903 |
44 | MP0005670_abnormal_white_adipose | 1.21473855 |
45 | MP0005257_abnormal_intraocular_pressure | 1.16341851 |
46 | MP0006035_abnormal_mitochondrial_morpho | 1.14789906 |
47 | MP0003632_abnormal_nervous_system | 1.12234474 |
48 | MP0008469_abnormal_protein_level | 1.10815366 |
49 | MP0003634_abnormal_glial_cell | 1.10766381 |
50 | MP0004858_abnormal_nervous_system | 1.07037718 |
51 | MP0003172_abnormal_lysosome_physiology | 1.06683713 |
52 | MP0000647_abnormal_sebaceous_gland | 1.04831324 |
53 | MP0003656_abnormal_erythrocyte_physiolo | 1.04371121 |
54 | MP0000383_abnormal_hair_follicle | 1.01350624 |
55 | MP0010678_abnormal_skin_adnexa | 1.01072459 |
56 | MP0002332_abnormal_exercise_endurance | 1.01057802 |
57 | MP0003186_abnormal_redox_activity | 1.00965914 |
58 | MP0006292_abnormal_olfactory_placode | 1.00786711 |
59 | MP0003890_abnormal_embryonic-extraembry | 1.00370113 |
60 | MP0003303_peritoneal_inflammation | 0.99955425 |
61 | MP0006036_abnormal_mitochondrial_physio | 0.98054196 |
62 | MP0002148_abnormal_hypersensitivity_rea | 0.96973629 |
63 | MP0002168_other_aberrant_phenotype | 0.96127986 |
64 | MP0005410_abnormal_fertilization | 0.95479154 |
65 | MP0001486_abnormal_startle_reflex | 0.95278514 |
66 | MP0004510_myositis | 0.94063907 |
67 | MP0000762_abnormal_tongue_morphology | 0.92932467 |
68 | MP0008872_abnormal_physiological_respon | 0.92154566 |
69 | MP0005395_other_phenotype | 0.90294609 |
70 | MP0005387_immune_system_phenotype | 0.89210243 |
71 | MP0001790_abnormal_immune_system | 0.89210243 |
72 | * MP0002229_neurodegeneration | 0.88728063 |
73 | MP0003879_abnormal_hair_cell | 0.87973725 |
74 | MP0005266_abnormal_metabolism | 0.87703161 |
75 | MP0003938_abnormal_ear_development | 0.86038490 |
76 | MP0003705_abnormal_hypodermis_morpholog | 0.82331087 |
77 | MP0000639_abnormal_adrenal_gland | 0.80853841 |
78 | MP0009765_abnormal_xenobiotic_induced | 0.80579073 |
79 | MP0004742_abnormal_vestibular_system | 0.80112492 |
80 | MP0000579_abnormal_nail_morphology | 0.79326039 |
81 | MP0001905_abnormal_dopamine_level | 0.78873440 |
82 | MP0005647_abnormal_sex_gland | 0.78447798 |
83 | MP0009643_abnormal_urine_homeostasis | 0.77215816 |
84 | MP0009642_abnormal_blood_homeostasis | 0.76571847 |
85 | MP0001661_extended_life_span | 0.76391608 |
86 | MP0000462_abnormal_digestive_system | 0.75890728 |
87 | MP0005084_abnormal_gallbladder_morpholo | 0.73211132 |
88 | MP0005408_hypopigmentation | 0.73143054 |
89 | MP0003075_altered_response_to | 0.72726709 |
90 | MP0004270_analgesia | 0.71552293 |
91 | MP0005167_abnormal_blood-brain_barrier | 0.70593574 |
92 | MP0005376_homeostasis/metabolism_phenot | 0.70415860 |
93 | MP0000598_abnormal_liver_morphology | 0.70372242 |
94 | MP0002272_abnormal_nervous_system | 0.69885190 |
95 | MP0000371_diluted_coat_color | 0.68760692 |
96 | MP0005025_abnormal_response_to | 0.68346595 |
97 | MP0009763_increased_sensitivity_to | 0.68008768 |
98 | MP0005551_abnormal_eye_electrophysiolog | 0.66456835 |
99 | MP0002796_impaired_skin_barrier | 0.65696749 |
100 | MP0000343_altered_response_to | 0.65392324 |
101 | MP0003136_yellow_coat_color | 0.64742085 |
102 | MP0005397_hematopoietic_system_phenotyp | 0.64379197 |
103 | MP0001545_abnormal_hematopoietic_system | 0.64379197 |
104 | MP0005499_abnormal_olfactory_system | 0.63917377 |
105 | MP0005394_taste/olfaction_phenotype | 0.63917377 |
106 | MP0005023_abnormal_wound_healing | 0.63220726 |
107 | MP0002282_abnormal_trachea_morphology | 0.63064387 |
108 | MP0002136_abnormal_kidney_physiology | 0.63052572 |
109 | MP0010368_abnormal_lymphatic_system | 0.62961150 |
110 | MP0001529_abnormal_vocalization | 0.62189838 |
111 | MP0000249_abnormal_blood_vessel | 0.61899104 |
112 | MP0003631_nervous_system_phenotype | 0.60985525 |
113 | MP0002092_abnormal_eye_morphology | 0.60401487 |
114 | MP0001348_abnormal_lacrimal_gland | 0.59527206 |
115 | MP0005671_abnormal_response_to | 0.59097381 |
116 | MP0005195_abnormal_posterior_eye | 0.58783169 |
117 | MP0005166_decreased_susceptibility_to | 0.58766837 |
118 | MP0002419_abnormal_innate_immunity | 0.57986779 |
119 | MP0001764_abnormal_homeostasis | 0.57005394 |
120 | MP0003436_decreased_susceptibility_to | 0.56910089 |
121 | MP0003724_increased_susceptibility_to | 0.56550392 |
122 | MP0003453_abnormal_keratinocyte_physiol | 0.55868903 |
123 | MP0000467_abnormal_esophagus_morphology | 0.55648761 |
124 | MP0002971_abnormal_brown_adipose | 0.54895055 |
125 | MP0000955_abnormal_spinal_cord | 0.54769956 |
126 | MP0006054_spinal_hemorrhage | 0.54643945 |
127 | MP0001845_abnormal_inflammatory_respons | 0.54359259 |
128 | MP0000778_abnormal_nervous_system | 0.54124163 |
129 | MP0010155_abnormal_intestine_physiology | 0.53253718 |
130 | MP0002089_abnormal_postnatal_growth/wei | 0.52334840 |
131 | MP0003633_abnormal_nervous_system | 0.51497568 |
132 | MP0008873_increased_physiological_sensi | 0.51013456 |
133 | MP0005535_abnormal_body_temperature | 0.50989660 |
134 | MP0005164_abnormal_response_to | 0.50871611 |
135 | MP0002090_abnormal_vision | 0.50533164 |
136 | MP0010386_abnormal_urinary_bladder | 0.50416410 |
137 | MP0004883_abnormal_blood_vessel | 0.50330506 |
138 | MP0003183_abnormal_peptide_metabolism | 0.49749836 |
139 | MP0002138_abnormal_hepatobiliary_system | 0.49333873 |
140 | * MP0002752_abnormal_somatic_nervous | 0.49235616 |
141 | MP0001485_abnormal_pinna_reflex | 0.49096282 |
142 | MP0009697_abnormal_copulation | 0.48839742 |
143 | MP0005636_abnormal_mineral_homeostasis | 0.48305182 |
144 | MP0003718_maternal_effect | 0.48006104 |
145 | MP0002064_seizures | 0.48002308 |
146 | MP0002098_abnormal_vibrissa_morphology | 0.47911498 |
147 | MP0002249_abnormal_larynx_morphology | 0.47300762 |
148 | MP0001243_abnormal_dermal_layer | 0.47213405 |
149 | MP0002295_abnormal_pulmonary_circulatio | 0.47154997 |
150 | MP0001800_abnormal_humoral_immune | 0.47102437 |
151 | MP0001756_abnormal_urination | 0.46616426 |
152 | MP0001853_heart_inflammation | 0.46087906 |
153 | MP0005000_abnormal_immune_tolerance | 0.44665066 |
154 | MP0008874_decreased_physiological_sensi | 0.44037744 |
155 | MP0002078_abnormal_glucose_homeostasis | 0.42855799 |
156 | MP0008004_abnormal_stomach_pH | 0.42060607 |
157 | MP0001851_eye_inflammation | 0.41451480 |
158 | MP0005334_abnormal_fat_pad | 0.40704852 |
159 | MP0001915_intracranial_hemorrhage | 0.39352315 |
160 | MP0002909_abnormal_adrenal_gland | 0.39095451 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Systemic lupus erythematosus (HP:0002725) | 6.34978720 |
2 | Intrahepatic cholestasis (HP:0001406) | 6.14334223 |
3 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 6.13157514 |
4 | Deep venous thrombosis (HP:0002625) | 5.48400134 |
5 | Glomerulonephritis (HP:0000099) | 5.26702103 |
6 | Xanthomatosis (HP:0000991) | 4.95951478 |
7 | Hypochromic microcytic anemia (HP:0004840) | 4.74908616 |
8 | Hyperlipoproteinemia (HP:0010980) | 4.60969670 |
9 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 4.55208903 |
10 | Sensory axonal neuropathy (HP:0003390) | 4.39566702 |
11 | Prolonged partial thromboplastin time (HP:0003645) | 4.37837258 |
12 | Neurofibrillary tangles (HP:0002185) | 4.01482726 |
13 | Hypobetalipoproteinemia (HP:0003563) | 4.00101642 |
14 | Nephritis (HP:0000123) | 3.95183897 |
15 | Menorrhagia (HP:0000132) | 3.89237520 |
16 | Abnormality of the corticospinal tract (HP:0002492) | 3.71746919 |
17 | Complement deficiency (HP:0004431) | 3.56110986 |
18 | Abnormality of methionine metabolism (HP:0010901) | 3.48457303 |
19 | Abnormality of glycine metabolism (HP:0010895) | 3.36130345 |
20 | Abnormality of serine family amino acid metabolism (HP:0010894) | 3.36130345 |
21 | Joint hemorrhage (HP:0005261) | 3.35319618 |
22 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 3.34392421 |
23 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 3.34392421 |
24 | Hemorrhage of the eye (HP:0011885) | 3.30830874 |
25 | Hyperammonemia (HP:0001987) | 3.28434044 |
26 | Purpura (HP:0000979) | 3.27108564 |
27 | Bilateral microphthalmos (HP:0007633) | 3.26212963 |
28 | Abnormality of glycolysis (HP:0004366) | 3.23695395 |
29 | Increased serum pyruvate (HP:0003542) | 3.23695395 |
30 | Abnormality of the intrinsic pathway (HP:0010989) | 3.21826813 |
31 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 3.17595863 |
32 | Epidermoid cyst (HP:0200040) | 3.17161394 |
33 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.16449687 |
34 | Anomalous pulmonary venous return (HP:0010772) | 3.16122485 |
35 | Amyloidosis (HP:0011034) | 2.99937246 |
36 | Mitral stenosis (HP:0001718) | 2.99801818 |
37 | Fat malabsorption (HP:0002630) | 2.98886217 |
38 | Gingival bleeding (HP:0000225) | 2.97950753 |
39 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.97372566 |
40 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 2.97151456 |
41 | Hypolipoproteinemia (HP:0010981) | 2.95806117 |
42 | Cerebral inclusion bodies (HP:0100314) | 2.93752270 |
43 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.91469400 |
44 | Hyperglycinuria (HP:0003108) | 2.88282977 |
45 | Ketosis (HP:0001946) | 2.86471598 |
46 | Spastic paraparesis (HP:0002313) | 2.86327272 |
47 | Vacuolated lymphocytes (HP:0001922) | 2.80325340 |
48 | Hyperglycinemia (HP:0002154) | 2.79594482 |
49 | Spastic tetraparesis (HP:0001285) | 2.77799483 |
50 | Abnormality of nucleobase metabolism (HP:0010932) | 2.76900099 |
51 | Hyperventilation (HP:0002883) | 2.74217382 |
52 | Abnormality of the common coagulation pathway (HP:0010990) | 2.72415963 |
53 | Partial duplication of thumb phalanx (HP:0009944) | 2.72156426 |
54 | Abnormality of proline metabolism (HP:0010907) | 2.70848754 |
55 | Hydroxyprolinuria (HP:0003080) | 2.70848754 |
56 | Hypoalphalipoproteinemia (HP:0003233) | 2.68283684 |
57 | Skin nodule (HP:0200036) | 2.68041713 |
58 | Abnormality of the pulmonary veins (HP:0011718) | 2.67126173 |
59 | Hepatoblastoma (HP:0002884) | 2.64774947 |
60 | Abnormality of complement system (HP:0005339) | 2.55204953 |
61 | Hypercholesterolemia (HP:0003124) | 2.53058544 |
62 | Abnormality of the lower motor neuron (HP:0002366) | 2.52288406 |
63 | J-shaped sella turcica (HP:0002680) | 2.50474971 |
64 | Cerebral hypomyelination (HP:0006808) | 2.45395582 |
65 | Epistaxis (HP:0000421) | 2.44873118 |
66 | Steatorrhea (HP:0002570) | 2.44693860 |
67 | Pulmonary embolism (HP:0002204) | 2.42505797 |
68 | Delayed CNS myelination (HP:0002188) | 2.42202644 |
69 | Late onset (HP:0003584) | 2.42041061 |
70 | Onion bulb formation (HP:0003383) | 2.41897699 |
71 | Cardiovascular calcification (HP:0011915) | 2.40056330 |
72 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 2.39785383 |
73 | Malnutrition (HP:0004395) | 2.38761740 |
74 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 2.34846266 |
75 | Generalized aminoaciduria (HP:0002909) | 2.32803921 |
76 | Myocardial infarction (HP:0001658) | 2.27906674 |
77 | Partial duplication of the phalanx of hand (HP:0009999) | 2.26856273 |
78 | Spontaneous abortion (HP:0005268) | 2.26217054 |
79 | Impaired platelet aggregation (HP:0003540) | 2.24298520 |
80 | Abnormal platelet function (HP:0011869) | 2.24298520 |
81 | Cholecystitis (HP:0001082) | 2.23931090 |
82 | Abnormal gallbladder physiology (HP:0012438) | 2.23931090 |
83 | Abnormal gallbladder morphology (HP:0012437) | 2.22798430 |
84 | Hepatocellular carcinoma (HP:0001402) | 2.22466977 |
85 | Mucopolysacchariduria (HP:0008155) | 2.22275863 |
86 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.22275863 |
87 | Rickets (HP:0002748) | 2.21904909 |
88 | Thrombophlebitis (HP:0004418) | 2.21770766 |
89 | Irritability (HP:0000737) | 2.20995790 |
90 | 3-Methylglutaconic aciduria (HP:0003535) | 2.18431034 |
91 | Abnormality of the salivary glands (HP:0010286) | 2.15166699 |
92 | Intention tremor (HP:0002080) | 2.14642479 |
93 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.14381185 |
94 | Parakeratosis (HP:0001036) | 2.14020979 |
95 | Abnormal cartilage morphology (HP:0002763) | 2.12611537 |
96 | Hyperbilirubinemia (HP:0002904) | 2.11468333 |
97 | Dysostosis multiplex (HP:0000943) | 2.11375438 |
98 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.11018877 |
99 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.11018877 |
100 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.11018877 |
101 | Paraparesis (HP:0002385) | 2.09352252 |
102 | Conjugated hyperbilirubinemia (HP:0002908) | 2.09245181 |
103 | Abnormality of the Achilles tendon (HP:0005109) | 2.07935826 |
104 | Spastic gait (HP:0002064) | 2.05862661 |
105 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.04236418 |
106 | Abnormal auditory evoked potentials (HP:0006958) | 2.03199061 |
107 | Decreased central vision (HP:0007663) | 2.03051478 |
108 | Gangrene (HP:0100758) | 2.02702336 |
109 | Vascular calcification (HP:0004934) | 2.01669074 |
110 | Ketoacidosis (HP:0001993) | 2.00674926 |
111 | Metabolic acidosis (HP:0001942) | 1.99265214 |
112 | Cholelithiasis (HP:0001081) | 1.99000418 |
113 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.98147451 |
114 | Increased serum ferritin (HP:0003281) | 1.95425746 |
115 | Infantile muscular hypotonia (HP:0008947) | 1.94786945 |
116 | Peripheral demyelination (HP:0011096) | 1.94366462 |
117 | Abnormality of serum amino acid levels (HP:0003112) | 1.93869117 |
118 | Hypophosphatemic rickets (HP:0004912) | 1.93469319 |
119 | Hypoglycemic coma (HP:0001325) | 1.93469068 |
120 | Fair hair (HP:0002286) | 1.93331423 |
121 | Abnormal biliary tract physiology (HP:0012439) | 1.92495017 |
122 | Bile duct proliferation (HP:0001408) | 1.92495017 |
123 | Gout (HP:0001997) | 1.90744839 |
124 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.90408899 |
125 | Multiple enchondromatosis (HP:0005701) | 1.90343442 |
126 | Peripheral hypomyelination (HP:0007182) | 1.87789235 |
127 | Lethargy (HP:0001254) | 1.87781661 |
128 | Arthropathy (HP:0003040) | 1.87017501 |
129 | Progressive external ophthalmoplegia (HP:0000590) | 1.86733992 |
130 | Generalized hypopigmentation of hair (HP:0011358) | 1.86665136 |
131 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.86430409 |
132 | Dicarboxylic aciduria (HP:0003215) | 1.86430409 |
133 | Ragged-red muscle fibers (HP:0003200) | 1.81097834 |
134 | Panhypogammaglobulinemia (HP:0003139) | 1.79748150 |
135 | Enlarged kidneys (HP:0000105) | 1.79549674 |
136 | Tetraplegia (HP:0002445) | 1.78717468 |
137 | Bifid scrotum (HP:0000048) | 1.78572360 |
138 | Axonal loss (HP:0003447) | 1.78343224 |
139 | Abnormal enzyme/coenzyme activity (HP:0012379) | 1.77982130 |
140 | Increased mean platelet volume (HP:0011877) | 1.76063806 |
141 | Abnormality of liposaccharide metabolism (HP:0010968) | 1.70361527 |
142 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 1.70361527 |
143 | Abnormality of glycolipid metabolism (HP:0010969) | 1.70361527 |
144 | Abnormality of iron homeostasis (HP:0011031) | 1.69812585 |
145 | Abnormality of purine metabolism (HP:0004352) | 1.68114820 |
146 | Nonimmune hydrops fetalis (HP:0001790) | 1.68025136 |
147 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.64075206 |
148 | Retinal atrophy (HP:0001105) | 1.63007496 |
149 | Osteomalacia (HP:0002749) | 1.62889190 |
150 | Reticulocytosis (HP:0001923) | 1.62329303 |
151 | Prolonged bleeding time (HP:0003010) | 1.60200880 |
152 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.59026159 |
153 | Joint swelling (HP:0001386) | 1.58559717 |
154 | Reduced antithrombin III activity (HP:0001976) | 1.55034459 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PDK2 | 4.58594087 |
2 | STK39 | 4.48702895 |
3 | ERN1 | 3.45491515 |
4 | GRK5 | 3.42887718 |
5 | CDK12 | 3.36370376 |
6 | EPHB1 | 3.18048613 |
7 | GRK1 | 3.09498424 |
8 | OXSR1 | 3.03675092 |
9 | IRAK3 | 3.00478573 |
10 | GRK6 | 2.83553255 |
11 | PKN1 | 2.69155013 |
12 | PIM2 | 2.67548961 |
13 | FGFR3 | 2.50464668 |
14 | ADRBK2 | 2.49543999 |
15 | TYRO3 | 2.41103956 |
16 | MAP3K3 | 2.34396976 |
17 | NTRK1 | 2.29188420 |
18 | TBK1 | 2.29074144 |
19 | WNK1 | 2.25409688 |
20 | ARAF | 2.14975494 |
21 | BCKDK | 2.10610573 |
22 | CSF1R | 1.97360914 |
23 | TESK2 | 1.92858067 |
24 | MET | 1.92302448 |
25 | MAPK7 | 1.90236261 |
26 | PBK | 1.87309475 |
27 | FGFR2 | 1.81422924 |
28 | EIF2AK3 | 1.81210490 |
29 | GRK7 | 1.69741462 |
30 | BCR | 1.68817925 |
31 | IKBKB | 1.64865693 |
32 | ICK | 1.61515533 |
33 | ERBB4 | 1.60320029 |
34 | MAP3K14 | 1.56636915 |
35 | FRK | 1.56063809 |
36 | TIE1 | 1.53794721 |
37 | WNK4 | 1.52084125 |
38 | TAOK2 | 1.51884520 |
39 | TEC | 1.50668466 |
40 | MAP4K1 | 1.44279713 |
41 | SYK | 1.37666454 |
42 | MAP3K1 | 1.37643478 |
43 | MARK2 | 1.32985339 |
44 | IKBKE | 1.25957157 |
45 | SIK1 | 1.24964759 |
46 | TXK | 1.23316347 |
47 | NEK9 | 1.20023886 |
48 | MAP2K7 | 1.17798834 |
49 | CSNK1G3 | 1.16805893 |
50 | NME2 | 1.16502284 |
51 | PINK1 | 1.16286462 |
52 | UHMK1 | 1.14240331 |
53 | PRPF4B | 1.11883625 |
54 | MOS | 1.11847025 |
55 | MAP2K4 | 1.11764388 |
56 | TGFBR2 | 1.09133776 |
57 | PTK2B | 1.09013765 |
58 | CSNK1A1L | 1.08197135 |
59 | PKN2 | 1.08130294 |
60 | MAPKAPK5 | 1.07555597 |
61 | FGFR4 | 1.05768296 |
62 | KDR | 1.02180653 |
63 | MATK | 1.01012947 |
64 | BMPR1B | 0.95544873 |
65 | DYRK2 | 0.93761211 |
66 | CDK19 | 0.93092559 |
67 | TNIK | 0.92808473 |
68 | IRAK2 | 0.90252730 |
69 | RPS6KC1 | 0.90210459 |
70 | RPS6KL1 | 0.90210459 |
71 | RPS6KA6 | 0.90207363 |
72 | CSNK1G1 | 0.89875983 |
73 | FGR | 0.85672582 |
74 | CAMK2B | 0.84384952 |
75 | CAMK2G | 0.83830572 |
76 | GSK3A | 0.80203563 |
77 | TAOK1 | 0.80154916 |
78 | DYRK1B | 0.79447624 |
79 | ROCK2 | 0.79239257 |
80 | TYK2 | 0.79044391 |
81 | LIMK1 | 0.78754304 |
82 | CHUK | 0.78620369 |
83 | LMTK2 | 0.78209288 |
84 | DYRK1A | 0.77313830 |
85 | RIPK4 | 0.76981634 |
86 | MAPK12 | 0.76128850 |
87 | FER | 0.75961260 |
88 | CSNK1G2 | 0.75898201 |
89 | CSK | 0.75881740 |
90 | CAMK4 | 0.75308841 |
91 | PRKG2 | 0.74563335 |
92 | PAK6 | 0.74428995 |
93 | MAP3K7 | 0.74213153 |
94 | STK10 | 0.73752830 |
95 | MAP3K4 | 0.72761119 |
96 | PAK3 | 0.72109043 |
97 | NTRK3 | 0.70060418 |
98 | NEK6 | 0.67885255 |
99 | DAPK2 | 0.66768799 |
100 | KIT | 0.64727603 |
101 | CAMK2D | 0.64151829 |
102 | TTK | 0.63635118 |
103 | PRKCQ | 0.63414512 |
104 | ADRBK1 | 0.62542304 |
105 | MAP4K2 | 0.61246963 |
106 | LYN | 0.60938322 |
107 | ABL2 | 0.60853419 |
108 | INSRR | 0.60584351 |
109 | PRKD1 | 0.60185281 |
110 | PTK2 | 0.57699110 |
111 | ERBB2 | 0.56652516 |
112 | MUSK | 0.54463049 |
113 | SGK223 | 0.54308842 |
114 | SGK494 | 0.54308842 |
115 | STK38 | 0.54262344 |
116 | ITK | 0.53779177 |
117 | MAPK15 | 0.52405448 |
118 | PRKCE | 0.52382240 |
119 | TAOK3 | 0.51931932 |
120 | PRKCG | 0.51341685 |
121 | PIK3CA | 0.50898594 |
122 | HIPK2 | 0.50704924 |
123 | IRAK1 | 0.50459748 |
124 | MAP3K10 | 0.50372892 |
125 | MAPK11 | 0.49328848 |
126 | PDPK1 | 0.47978401 |
127 | MAP2K3 | 0.47681645 |
128 | AKT2 | 0.47461305 |
129 | MAPKAPK3 | 0.47404249 |
130 | RPS6KB1 | 0.46191664 |
131 | CLK1 | 0.45743203 |
132 | EPHA4 | 0.45620042 |
133 | MAP3K5 | 0.44404912 |
134 | IRAK4 | 0.43942368 |
135 | BMPR2 | 0.43877663 |
136 | PRKACG | 0.43648405 |
137 | NLK | 0.43340902 |
138 | BMX | 0.43106626 |
139 | DDR2 | 0.43020936 |
140 | BLK | 0.42895989 |
141 | EPHA3 | 0.42809363 |
142 | ABL1 | 0.42258096 |
143 | MAP3K11 | 0.41773842 |
144 | CAMK2A | 0.40885827 |
145 | PRKACB | 0.39948106 |
146 | MAPK4 | 0.39621197 |
147 | MAPK3 | 0.37873877 |
148 | CSNK1E | 0.37578427 |
149 | PIK3CG | 0.37243812 |
150 | FYN | 0.37238370 |
151 | IGF1R | 0.37073276 |
152 | RAF1 | 0.36954787 |
153 | RPS6KB2 | 0.36299167 |
154 | CDK15 | 0.35749281 |
155 | CDK14 | 0.35484904 |
156 | DAPK3 | 0.35157540 |
157 | CSNK1A1 | 0.34538236 |
158 | PRKACA | 0.34357274 |
159 | CASK | 0.33170768 |
160 | MAP2K6 | 0.32861418 |
161 | INSR | 0.32779458 |
162 | PRKAA2 | 0.32092205 |
163 | PRKCZ | 0.31892871 |
164 | PDK1 | 0.31874637 |
165 | MST1R | 0.31835361 |
166 | EPHA2 | 0.31651735 |
167 | CSNK1D | 0.31275584 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 3.63880436 |
2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.42682855 |
3 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 3.34555691 |
4 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 3.15617456 |
5 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.97762124 |
6 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.79585524 |
7 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.68824733 |
8 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.67246685 |
9 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.50442671 |
10 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.43773416 |
11 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 2.37555375 |
12 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.37242470 |
13 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.34030518 |
14 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.31220855 |
15 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.23636960 |
16 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.19620911 |
17 | Histidine metabolism_Homo sapiens_hsa00340 | 2.12206796 |
18 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.11905572 |
19 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.10888179 |
20 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.01526255 |
21 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.94358223 |
22 | Peroxisome_Homo sapiens_hsa04146 | 1.88664277 |
23 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.87994563 |
24 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.81100582 |
25 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.78984862 |
26 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.78087565 |
27 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.68763183 |
28 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.61264356 |
29 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.57409967 |
30 | Retinol metabolism_Homo sapiens_hsa00830 | 1.57361047 |
31 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.52895181 |
32 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.51734394 |
33 | Other glycan degradation_Homo sapiens_hsa00511 | 1.47201830 |
34 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.46233636 |
35 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.41014448 |
36 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.37639374 |
37 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.31299290 |
38 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.30438465 |
39 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.27648613 |
40 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.25092221 |
41 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.24030825 |
42 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.22086175 |
43 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.21157746 |
44 | Bile secretion_Homo sapiens_hsa04976 | 1.20806370 |
45 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.15830101 |
46 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.14018447 |
47 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.12839853 |
48 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.07103366 |
49 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.05096420 |
50 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.03337821 |
51 | ABC transporters_Homo sapiens_hsa02010 | 0.99543648 |
52 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.98421609 |
53 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.92154704 |
54 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.90512506 |
55 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.90467814 |
56 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.83892781 |
57 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.82823206 |
58 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.82068578 |
59 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.79007327 |
60 | Sulfur relay system_Homo sapiens_hsa04122 | 0.77880355 |
61 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.76460623 |
62 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.75929726 |
63 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.75165105 |
64 | Carbon metabolism_Homo sapiens_hsa01200 | 0.75107811 |
65 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.75077253 |
66 | Pertussis_Homo sapiens_hsa05133 | 0.73175125 |
67 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.66206518 |
68 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.65663842 |
69 | Metabolic pathways_Homo sapiens_hsa01100 | 0.60312044 |
70 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.59799716 |
71 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.58609648 |
72 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.50345719 |
73 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.47694782 |
74 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.47480547 |
75 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.45961505 |
76 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.45509720 |
77 | Lysine degradation_Homo sapiens_hsa00310 | 0.44873511 |
78 | Prion diseases_Homo sapiens_hsa05020 | 0.35691134 |
79 | Insulin resistance_Homo sapiens_hsa04931 | 0.29455132 |
80 | Axon guidance_Homo sapiens_hsa04360 | 0.29049055 |
81 | Lysosome_Homo sapiens_hsa04142 | 0.28926799 |
82 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.28352463 |
83 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.27274279 |
84 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.27198391 |
85 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.26973952 |
86 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.23780771 |
87 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.21488360 |
88 | Galactose metabolism_Homo sapiens_hsa00052 | 0.19957270 |
89 | * Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.18532681 |
90 | Asthma_Homo sapiens_hsa05310 | 0.15652256 |
91 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.14996635 |
92 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.14256970 |
93 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.13527033 |
94 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.13187901 |
95 | Allograft rejection_Homo sapiens_hsa05330 | 0.12075464 |
96 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.11363129 |
97 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.10999390 |
98 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.09851580 |
99 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.05611832 |
100 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.05266103 |
101 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.04026745 |
102 | Malaria_Homo sapiens_hsa05144 | 0.03732710 |
103 | Amoebiasis_Homo sapiens_hsa05146 | 0.03690456 |
104 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.03323945 |
105 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.01781067 |
106 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.01587843 |
107 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | -0.1040294 |
108 | AMPK signaling pathway_Homo sapiens_hsa04152 | -0.0977494 |
109 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | -0.0945496 |
110 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | -0.0876348 |
111 | Ras signaling pathway_Homo sapiens_hsa04014 | -0.0845671 |
112 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | -0.0815145 |
113 | Serotonergic synapse_Homo sapiens_hsa04726 | -0.0574601 |
114 | Protein export_Homo sapiens_hsa03060 | -0.0539515 |
115 | Glutamatergic synapse_Homo sapiens_hsa04724 | -0.0460787 |
116 | Alzheimers disease_Homo sapiens_hsa05010 | -0.0408742 |
117 | TNF signaling pathway_Homo sapiens_hsa04668 | -0.0340302 |
118 | Glucagon signaling pathway_Homo sapiens_hsa04922 | -0.0337380 |
119 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | -0.0290197 |
120 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | -0.0225513 |
121 | Regulation of autophagy_Homo sapiens_hsa04140 | -0.0209841 |
122 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | -0.0204105 |
123 | GABAergic synapse_Homo sapiens_hsa04727 | -0.0142637 |
124 | African trypanosomiasis_Homo sapiens_hsa05143 | -0.0093780 |
125 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | -0.0091829 |
126 | Mineral absorption_Homo sapiens_hsa04978 | -0.0069986 |