CLDN14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.11981004
2drug catabolic process (GO:0042737)7.05951766
3L-phenylalanine catabolic process (GO:0006559)6.92464539
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.92464539
5L-phenylalanine metabolic process (GO:0006558)6.60285920
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.60285920
7omega-hydroxylase P450 pathway (GO:0097267)6.48189905
8fatty acid elongation (GO:0030497)6.01175382
9coenzyme catabolic process (GO:0009109)5.87989269
10axon ensheathment in central nervous system (GO:0032291)5.82479689
11central nervous system myelination (GO:0022010)5.82479689
12regulation of plasminogen activation (GO:0010755)5.60723905
13aromatic amino acid family catabolic process (GO:0009074)5.58431349
14heme transport (GO:0015886)5.48756235
15blood coagulation, intrinsic pathway (GO:0007597)5.18868609
16imidazole-containing compound metabolic process (GO:0052803)4.95067199
17glyoxylate metabolic process (GO:0046487)4.94163975
18negative regulation of blood coagulation (GO:0030195)4.88977361
19negative regulation of hemostasis (GO:1900047)4.88977361
20sulfur amino acid catabolic process (GO:0000098)4.82762732
21bile acid biosynthetic process (GO:0006699)4.73280565
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.71139291
23positive regulation of blood coagulation (GO:0030194)4.67207752
24positive regulation of hemostasis (GO:1900048)4.67207752
25negative regulation of coagulation (GO:0050819)4.62152796
26protein activation cascade (GO:0072376)4.55697097
27cofactor catabolic process (GO:0051187)4.50688361
28S-adenosylmethionine metabolic process (GO:0046500)4.50625119
29alpha-linolenic acid metabolic process (GO:0036109)4.47864797
30positive regulation of fatty acid biosynthetic process (GO:0045723)4.43677691
31cellular modified amino acid catabolic process (GO:0042219)4.38101772
32tryptophan catabolic process (GO:0006569)4.37870194
33indole-containing compound catabolic process (GO:0042436)4.37870194
34indolalkylamine catabolic process (GO:0046218)4.37870194
35negative regulation of fibrinolysis (GO:0051918)4.36936332
36oxidative demethylation (GO:0070989)4.32416090
37positive regulation of coagulation (GO:0050820)4.30678559
38phenylpropanoid metabolic process (GO:0009698)4.29109508
39negative regulation of wound healing (GO:0061045)4.27176609
40cholesterol biosynthetic process (GO:0006695)4.26712090
41acute-phase response (GO:0006953)4.22479008
42regulation of fibrinolysis (GO:0051917)4.21404706
43complement activation, classical pathway (GO:0006958)4.19083373
44kynurenine metabolic process (GO:0070189)4.17809065
45complement activation (GO:0006956)4.14016230
46high-density lipoprotein particle remodeling (GO:0034375)4.09863530
47regulation of humoral immune response (GO:0002920)4.06694691
48alkaloid metabolic process (GO:0009820)4.05988317
49tryptophan metabolic process (GO:0006568)4.05801056
50bile acid metabolic process (GO:0008206)4.04940439
51ethanol metabolic process (GO:0006067)4.04720504
52iron coordination entity transport (GO:1901678)4.02654014
53very long-chain fatty acid metabolic process (GO:0000038)4.01172257
54aromatic amino acid family metabolic process (GO:0009072)3.99332288
55peptidyl-glutamic acid carboxylation (GO:0017187)3.96626761
56protein carboxylation (GO:0018214)3.96626761
57regulation of protein activation cascade (GO:2000257)3.96406818
58tyrosine metabolic process (GO:0006570)3.91594964
59axon ensheathment (GO:0008366)3.87073031
60ensheathment of neurons (GO:0007272)3.87073031
61complement activation, alternative pathway (GO:0006957)3.86606782
62plasma lipoprotein particle clearance (GO:0034381)3.84945472
63very-low-density lipoprotein particle assembly (GO:0034379)3.83200658
64plasma lipoprotein particle organization (GO:0071827)3.82706842
65cellular glucuronidation (GO:0052695)3.81467674
66myelination (GO:0042552)3.77547395
67arginine catabolic process (GO:0006527)3.77454889
68cysteine metabolic process (GO:0006534)3.76523689
69regulation of cholesterol esterification (GO:0010872)3.76052754
70urea metabolic process (GO:0019627)3.72689495
71urea cycle (GO:0000050)3.72689495
72arginine metabolic process (GO:0006525)3.72583741
73fatty-acyl-CoA biosynthetic process (GO:0046949)3.71302249
74regulation of apoptotic cell clearance (GO:2000425)3.71273888
75long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.69509810
76sterol biosynthetic process (GO:0016126)3.67782371
77plasma lipoprotein particle assembly (GO:0034377)3.66566938
78negative regulation of lipid transport (GO:0032369)3.64342842
79regulation of triglyceride catabolic process (GO:0010896)3.64197601
80glucuronate metabolic process (GO:0019585)3.62635981
81uronic acid metabolic process (GO:0006063)3.62635981
82acylglycerol homeostasis (GO:0055090)3.62020225
83triglyceride homeostasis (GO:0070328)3.62020225
84epoxygenase P450 pathway (GO:0019373)3.61423672
85regulation of complement activation (GO:0030449)3.59923447
86lipoprotein metabolic process (GO:0042157)3.59257379
87alpha-amino acid catabolic process (GO:1901606)3.58510070
88protein-lipid complex subunit organization (GO:0071825)3.58033621
89response to dietary excess (GO:0002021)3.53390689
90flavonoid metabolic process (GO:0009812)3.53333530
91nitrogen cycle metabolic process (GO:0071941)3.51204461
92primary alcohol catabolic process (GO:0034310)3.51027991
93cellular amino acid catabolic process (GO:0009063)3.49260927
94positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.49108230
95reverse cholesterol transport (GO:0043691)3.47956649
96cholesterol efflux (GO:0033344)3.44365690
97cellular ketone body metabolic process (GO:0046950)3.43760637
98protein-lipid complex remodeling (GO:0034368)3.42921050
99macromolecular complex remodeling (GO:0034367)3.42921050
100plasma lipoprotein particle remodeling (GO:0034369)3.42921050
101negative regulation of protein activation cascade (GO:2000258)3.42007674
102acute inflammatory response (GO:0002526)3.41163117
103positive regulation of triglyceride lipase activity (GO:0061365)3.40876980
104positive regulation of lipoprotein lipase activity (GO:0051006)3.40876980
105intestinal cholesterol absorption (GO:0030299)3.40715684
106serine family amino acid catabolic process (GO:0009071)3.39129484
107amino-acid betaine metabolic process (GO:0006577)3.38614431
108myelin maintenance (GO:0043217)3.38351701
109negative regulation of fatty acid biosynthetic process (GO:0045717)3.37444410
110acetyl-CoA metabolic process (GO:0006084)3.36463441
111opsonization (GO:0008228)3.35890933
112serine family amino acid biosynthetic process (GO:0009070)3.35349536
113fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.35261206
114creatine metabolic process (GO:0006600)3.35135063
115cytolysis (GO:0019835)3.34070976
116low-density lipoprotein particle remodeling (GO:0034374)3.34064496
117L-serine metabolic process (GO:0006563)3.33717037
118drug metabolic process (GO:0017144)3.33626487
119aldehyde catabolic process (GO:0046185)3.32348615
120regulation of lipoprotein particle clearance (GO:0010984)3.31096475
121glycine metabolic process (GO:0006544)3.30928096
122fatty-acyl-CoA metabolic process (GO:0035337)3.30643154
123regulation of bile acid biosynthetic process (GO:0070857)3.25137535
124response to methylmercury (GO:0051597)3.24663360
125cellular biogenic amine catabolic process (GO:0042402)3.23937449
126amine catabolic process (GO:0009310)3.23937449
127cholesterol metabolic process (GO:0008203)3.20676255
128polyketide metabolic process (GO:0030638)3.20346669
129doxorubicin metabolic process (GO:0044598)3.20346669
130daunorubicin metabolic process (GO:0044597)3.20346669
131cholesterol homeostasis (GO:0042632)3.19976971
132phospholipid efflux (GO:0033700)3.19934902
133thioester biosynthetic process (GO:0035384)3.19746740
134acyl-CoA biosynthetic process (GO:0071616)3.19746740
135cofactor transport (GO:0051181)3.19693433
136negative regulation of sterol transport (GO:0032372)3.18362993
137negative regulation of cholesterol transport (GO:0032375)3.18362993
138long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.13628933
139fibrinolysis (GO:0042730)3.12153469
140sterol homeostasis (GO:0055092)3.12038309
141glutamate metabolic process (GO:0006536)3.11379034
142regulation of cholesterol metabolic process (GO:0090181)3.09980163
143negative regulation of lipase activity (GO:0060192)3.08464733
144biotin metabolic process (GO:0006768)3.08322274
145ethanol oxidation (GO:0006069)3.08063599
146hormone catabolic process (GO:0042447)3.07258960
147peroxisome fission (GO:0016559)3.06245453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.00868354
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.68737031
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.68280477
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.65311169
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.61717561
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.99312929
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.92811829
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.92811829
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.92811829
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.32654118
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.22711548
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.20881138
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.14157640
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.95709618
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55771521
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.50822442
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37124636
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98650699
19IRF1_19129219_ChIP-ChIP_H3396_Human1.95355914
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70230285
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53332969
22NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.52649988
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.49291359
24* GATA2_21666600_ChIP-Seq_HMVEC_Human1.47860277
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39939540
26SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.39365873
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36791617
28HTT_18923047_ChIP-ChIP_STHdh_Human1.35402211
29* FOXA2_19822575_ChIP-Seq_HepG2_Human1.33801855
30* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33616888
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33498492
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32602395
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26952073
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25140792
35TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22029020
36* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20920453
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.19203209
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17069368
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.14690567
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13719866
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11797315
42STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11492887
43SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10168374
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08479790
45EOMES_21245162_ChIP-Seq_HESCs_Human1.07345169
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06331017
47CDX2_20551321_ChIP-Seq_CACO-2_Human1.06032132
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.05948753
49* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04765263
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04540760
51AR_20517297_ChIP-Seq_VCAP_Human1.01836153
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00971452
53* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00697793
54POU5F1_16518401_ChIP-PET_MESCs_Mouse1.00097210
55ERG_21242973_ChIP-ChIP_JURKAT_Human0.99908669
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98896138
57CDX2_22108803_ChIP-Seq_LS180_Human0.98497926
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97987263
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97941791
60TRIM28_21343339_ChIP-Seq_HEK293_Human0.97421870
61* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96569390
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95998117
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95856583
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95839353
65ESET_19884257_ChIP-Seq_ESCs_Mouse0.95336384
66EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95019862
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94968813
68LXR_22292898_ChIP-Seq_THP-1_Human0.94687294
69MYC_19829295_ChIP-Seq_ESCs_Human0.93298217
70* RAC3_21632823_ChIP-Seq_H3396_Human0.92404009
71CEBPB_22108803_ChIP-Seq_LS180_Human0.92282357
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91620794
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91284959
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91264052
75* HNF4A_19822575_ChIP-Seq_HepG2_Human0.90693417
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90639516
77TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90025953
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88934951
79SCL_19346495_ChIP-Seq_HPC-7_Human0.88497535
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87892768
81PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87322579
82P53_21459846_ChIP-Seq_SAOS-2_Human0.86574986
83WT1_19549856_ChIP-ChIP_CCG9911_Human0.85750492
84CTCF_20526341_ChIP-Seq_ESCs_Human0.82652946
85BCL6_27268052_Chip-Seq_Bcells_Human0.82502649
86* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81613272
87BCAT_22108803_ChIP-Seq_LS180_Human0.81354009
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81106297
89ESR1_21235772_ChIP-Seq_MCF-7_Human0.81060659
90NANOG_18692474_ChIP-Seq_MESCs_Mouse0.80844842
91NANOG_18692474_ChIP-Seq_MEFs_Mouse0.78652799
92SPI1_20517297_ChIP-Seq_HL60_Human0.78258072
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77628902
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.77599237
95P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.77576554
96VDR_22108803_ChIP-Seq_LS180_Human0.76012725
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.73075791
98GATA4_25053715_ChIP-Seq_YYC3_Human0.72704376
99EZH2_18974828_ChIP-Seq_MESCs_Mouse0.71848977
100RNF2_18974828_ChIP-Seq_MESCs_Mouse0.71848977
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.71143998
102STAT1_20625510_ChIP-Seq_HELA_Human0.71085070
103CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.71028310
104FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.70920863
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.70663084
106CSB_26484114_Chip-Seq_FIBROBLAST_Human0.70059279
107ERG_20517297_ChIP-Seq_VCAP_Human0.69960315
108NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.69835347
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69781334
110NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69781334
111* RARB_24833708_ChIP-Seq_LIVER_Mouse0.69569279
112GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.69029958
113CRX_20693478_ChIP-Seq_RETINA_Mouse0.68573753
114FOXA1_25552417_ChIP-Seq_VCAP_Human0.68474041
115SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.68417033
116* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.68232189
117EZH2_27294783_Chip-Seq_NPCs_Mouse0.68027118
118IGF1R_20145208_ChIP-Seq_DFB_Human0.67953650
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.67497576
120FOXA1_27270436_Chip-Seq_PROSTATE_Human0.67134395
121FOXA1_25329375_ChIP-Seq_VCAP_Human0.67134395
122SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.66828631
123MTF2_20144788_ChIP-Seq_MESCs_Mouse0.66450710
124SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.66404928
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.66387930
126NANOG_19829295_ChIP-Seq_ESCs_Human0.66334339
127SOX2_19829295_ChIP-Seq_ESCs_Human0.66334339
128CJUN_26792858_Chip-Seq_BT549_Human0.66324756
129HNFA_21074721_ChIP-Seq_CACO-2_Human0.65968880
130PHF8_20622853_ChIP-Seq_HELA_Human0.65872484
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65397730
132SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.65253699
133* SMAD4_21741376_ChIP-Seq_EPCs_Human0.65144889
134FOXH1_21741376_ChIP-Seq_ESCs_Human0.65144697
135VDR_24787735_ChIP-Seq_THP-1_Human0.64990745
136P300_27268052_Chip-Seq_Bcells_Human0.64936429
137ERA_21632823_ChIP-Seq_H3396_Human0.64904427
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.64262361
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.63778776
140* E2F1_20622854_ChIP-Seq_HELA_Human0.63677653
141GATA6_21074721_ChIP-Seq_CACO-2_Human0.63154732
142JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62555528
143RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62290385
144* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.62222275
145BCOR_27268052_Chip-Seq_Bcells_Human0.62103665
146LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.61856887
147RARG_19884340_ChIP-ChIP_MEFs_Mouse0.61041660
148RING1B_27294783_Chip-Seq_NPCs_Mouse0.60959243
149NANOG_20526341_ChIP-Seq_ESCs_Human0.60752070
150GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.60750170
151SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.60693240
152ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.60591315
153NFE2_27457419_Chip-Seq_LIVER_Mouse0.59794482
154ESR1_20079471_ChIP-ChIP_T-47D_Human0.59672283
155* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.59327161
156NCOR_22424771_ChIP-Seq_293T_Human0.58902126
157STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.58651338
158DNAJC2_21179169_ChIP-ChIP_NT2_Human0.58635530
159EZH2_27294783_Chip-Seq_ESCs_Mouse0.58546244
160MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.57811735
161MYC_27129775_Chip-Seq_CORNEA_Mouse0.57289177
162MYC_19915707_ChIP-ChIP_AK7_Human0.57243785
163AUTS2_25519132_ChIP-Seq_293T-REX_Human0.57173170
164TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.56701837
165CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.56641085
166SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.55923840
167* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.55737650
168SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55560788
169POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.54899718
170GATA1_26923725_Chip-Seq_HPCs_Mouse0.54881315
171CTCF_27219007_Chip-Seq_Bcells_Human0.53914459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.26404561
2MP0005360_urolithiasis5.58676559
3MP0005085_abnormal_gallbladder_physiolo4.82517005
4MP0005365_abnormal_bile_salt4.41109588
5MP0008875_abnormal_xenobiotic_pharmacok4.32310885
6MP0003806_abnormal_nucleotide_metabolis4.28029990
7MP0003011_delayed_dark_adaptation3.69359293
8MP0009840_abnormal_foam_cell3.07873577
9MP0000920_abnormal_myelination3.06304919
10MP0003195_calcinosis2.81674600
11MP0003252_abnormal_bile_duct2.61170891
12MP0005083_abnormal_biliary_tract2.49180245
13MP0010329_abnormal_lipoprotein_level2.45806914
14MP0005451_abnormal_body_composition2.45684535
15MP0003690_abnormal_glial_cell2.26269381
16MP0005332_abnormal_amino_acid2.21969142
17MP0002254_reproductive_system_inflammat2.17958588
18MP0001666_abnormal_nutrient_absorption1.90011890
19MP0003191_abnormal_cellular_cholesterol1.84033992
20MP0002118_abnormal_lipid_homeostasis1.81404238
21MP0004381_abnormal_hair_follicle1.76552630
22MP0003329_amyloid_beta_deposits1.74431829
23MP0003950_abnormal_plasma_membrane1.70770179
24MP0000609_abnormal_liver_physiology1.55088012
25MP0000372_irregular_coat_pigmentation1.54113764
26MP0002876_abnormal_thyroid_physiology1.51459519
27MP0006082_CNS_inflammation1.51363416
28MP0005464_abnormal_platelet_physiology1.49247459
29MP0002132_abnormal_respiratory_system1.43859365
30MP0000604_amyloidosis1.43752991
31MP0005584_abnormal_enzyme/coenzyme_acti1.42692293
32MP0005058_abnormal_lysosome_morphology1.41346338
33MP0009785_altered_susceptibility_to1.40716715
34MP0000685_abnormal_immune_system1.38680385
35MP0004264_abnormal_extraembryonic_tissu1.37157105
36MP0004019_abnormal_vitamin_homeostasis1.36947384
37MP0005075_abnormal_melanosome_morpholog1.36811439
38MP0009764_decreased_sensitivity_to1.36720836
39MP0004043_abnormal_pH_regulation1.36152411
40MP0003868_abnormal_feces_composition1.31490845
41MP0004885_abnormal_endolymph1.30047665
42MP0005319_abnormal_enzyme/_coenzyme1.28250874
43MP0004142_abnormal_muscle_tone1.24896903
44MP0005670_abnormal_white_adipose1.21473855
45MP0005257_abnormal_intraocular_pressure1.16341851
46MP0006035_abnormal_mitochondrial_morpho1.14789906
47MP0003632_abnormal_nervous_system1.12234474
48MP0008469_abnormal_protein_level1.10815366
49MP0003634_abnormal_glial_cell1.10766381
50MP0004858_abnormal_nervous_system1.07037718
51MP0003172_abnormal_lysosome_physiology1.06683713
52MP0000647_abnormal_sebaceous_gland1.04831324
53MP0003656_abnormal_erythrocyte_physiolo1.04371121
54MP0000383_abnormal_hair_follicle1.01350624
55MP0010678_abnormal_skin_adnexa1.01072459
56MP0002332_abnormal_exercise_endurance1.01057802
57MP0003186_abnormal_redox_activity1.00965914
58MP0006292_abnormal_olfactory_placode1.00786711
59MP0003890_abnormal_embryonic-extraembry1.00370113
60MP0003303_peritoneal_inflammation0.99955425
61MP0006036_abnormal_mitochondrial_physio0.98054196
62MP0002148_abnormal_hypersensitivity_rea0.96973629
63MP0002168_other_aberrant_phenotype0.96127986
64MP0005410_abnormal_fertilization0.95479154
65MP0001486_abnormal_startle_reflex0.95278514
66MP0004510_myositis0.94063907
67MP0000762_abnormal_tongue_morphology0.92932467
68MP0008872_abnormal_physiological_respon0.92154566
69MP0005395_other_phenotype0.90294609
70MP0001790_abnormal_immune_system0.89210243
71MP0005387_immune_system_phenotype0.89210243
72* MP0002229_neurodegeneration0.88728063
73MP0003879_abnormal_hair_cell0.87973725
74MP0005266_abnormal_metabolism0.87703161
75MP0003938_abnormal_ear_development0.86038490
76MP0003705_abnormal_hypodermis_morpholog0.82331087
77MP0000639_abnormal_adrenal_gland0.80853841
78MP0009765_abnormal_xenobiotic_induced0.80579073
79MP0004742_abnormal_vestibular_system0.80112492
80MP0000579_abnormal_nail_morphology0.79326039
81MP0001905_abnormal_dopamine_level0.78873440
82MP0005647_abnormal_sex_gland0.78447798
83MP0009643_abnormal_urine_homeostasis0.77215816
84MP0009642_abnormal_blood_homeostasis0.76571847
85MP0001661_extended_life_span0.76391608
86MP0000462_abnormal_digestive_system0.75890728
87MP0005084_abnormal_gallbladder_morpholo0.73211132
88MP0005408_hypopigmentation0.73143054
89MP0003075_altered_response_to0.72726709
90MP0004270_analgesia0.71552293
91MP0005167_abnormal_blood-brain_barrier0.70593574
92MP0005376_homeostasis/metabolism_phenot0.70415860
93MP0000598_abnormal_liver_morphology0.70372242
94MP0002272_abnormal_nervous_system0.69885190
95MP0000371_diluted_coat_color0.68760692
96MP0005025_abnormal_response_to0.68346595
97MP0009763_increased_sensitivity_to0.68008768
98MP0005551_abnormal_eye_electrophysiolog0.66456835
99MP0002796_impaired_skin_barrier0.65696749
100MP0000343_altered_response_to0.65392324
101MP0003136_yellow_coat_color0.64742085
102MP0001545_abnormal_hematopoietic_system0.64379197
103MP0005397_hematopoietic_system_phenotyp0.64379197
104MP0005394_taste/olfaction_phenotype0.63917377
105MP0005499_abnormal_olfactory_system0.63917377
106MP0005023_abnormal_wound_healing0.63220726
107MP0002282_abnormal_trachea_morphology0.63064387
108MP0002136_abnormal_kidney_physiology0.63052572
109MP0010368_abnormal_lymphatic_system0.62961150
110MP0001529_abnormal_vocalization0.62189838
111MP0000249_abnormal_blood_vessel0.61899104
112MP0003631_nervous_system_phenotype0.60985525
113MP0002092_abnormal_eye_morphology0.60401487
114MP0001348_abnormal_lacrimal_gland0.59527206
115MP0005671_abnormal_response_to0.59097381
116MP0005195_abnormal_posterior_eye0.58783169
117MP0005166_decreased_susceptibility_to0.58766837
118MP0002419_abnormal_innate_immunity0.57986779
119MP0001764_abnormal_homeostasis0.57005394
120MP0003436_decreased_susceptibility_to0.56910089
121MP0003724_increased_susceptibility_to0.56550392
122MP0003453_abnormal_keratinocyte_physiol0.55868903
123MP0000467_abnormal_esophagus_morphology0.55648761
124MP0002971_abnormal_brown_adipose0.54895055
125MP0000955_abnormal_spinal_cord0.54769956
126MP0006054_spinal_hemorrhage0.54643945
127MP0001845_abnormal_inflammatory_respons0.54359259
128MP0000778_abnormal_nervous_system0.54124163
129MP0010155_abnormal_intestine_physiology0.53253718
130MP0002089_abnormal_postnatal_growth/wei0.52334840
131MP0003633_abnormal_nervous_system0.51497568
132MP0008873_increased_physiological_sensi0.51013456
133MP0005535_abnormal_body_temperature0.50989660
134MP0005164_abnormal_response_to0.50871611
135MP0002090_abnormal_vision0.50533164
136MP0010386_abnormal_urinary_bladder0.50416410
137MP0004883_abnormal_blood_vessel0.50330506
138MP0003183_abnormal_peptide_metabolism0.49749836
139MP0002138_abnormal_hepatobiliary_system0.49333873
140* MP0002752_abnormal_somatic_nervous0.49235616
141MP0001485_abnormal_pinna_reflex0.49096282
142MP0009697_abnormal_copulation0.48839742
143MP0005636_abnormal_mineral_homeostasis0.48305182
144MP0003718_maternal_effect0.48006104
145MP0002064_seizures0.48002308
146MP0002098_abnormal_vibrissa_morphology0.47911498
147MP0002249_abnormal_larynx_morphology0.47300762
148MP0001243_abnormal_dermal_layer0.47213405
149MP0002295_abnormal_pulmonary_circulatio0.47154997
150MP0001800_abnormal_humoral_immune0.47102437
151MP0001756_abnormal_urination0.46616426
152MP0001853_heart_inflammation0.46087906
153MP0005000_abnormal_immune_tolerance0.44665066
154MP0008874_decreased_physiological_sensi0.44037744
155MP0002078_abnormal_glucose_homeostasis0.42855799
156MP0008004_abnormal_stomach_pH0.42060607
157MP0001851_eye_inflammation0.41451480
158MP0005334_abnormal_fat_pad0.40704852
159MP0001915_intracranial_hemorrhage0.39352315
160MP0002909_abnormal_adrenal_gland0.39095451

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.34978720
2Intrahepatic cholestasis (HP:0001406)6.14334223
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.13157514
4Deep venous thrombosis (HP:0002625)5.48400134
5Glomerulonephritis (HP:0000099)5.26702103
6Xanthomatosis (HP:0000991)4.95951478
7Hypochromic microcytic anemia (HP:0004840)4.74908616
8Hyperlipoproteinemia (HP:0010980)4.60969670
9Abnormality of monocarboxylic acid metabolism (HP:0010996)4.55208903
10Sensory axonal neuropathy (HP:0003390)4.39566702
11Prolonged partial thromboplastin time (HP:0003645)4.37837258
12Neurofibrillary tangles (HP:0002185)4.01482726
13Hypobetalipoproteinemia (HP:0003563)4.00101642
14Nephritis (HP:0000123)3.95183897
15Menorrhagia (HP:0000132)3.89237520
16Abnormality of the corticospinal tract (HP:0002492)3.71746919
17Complement deficiency (HP:0004431)3.56110986
18Abnormality of methionine metabolism (HP:0010901)3.48457303
19Abnormality of serine family amino acid metabolism (HP:0010894)3.36130345
20Abnormality of glycine metabolism (HP:0010895)3.36130345
21Joint hemorrhage (HP:0005261)3.35319618
22Degeneration of the lateral corticospinal tracts (HP:0002314)3.34392421
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.34392421
24Hemorrhage of the eye (HP:0011885)3.30830874
25Hyperammonemia (HP:0001987)3.28434044
26Purpura (HP:0000979)3.27108564
27Bilateral microphthalmos (HP:0007633)3.26212963
28Abnormality of glycolysis (HP:0004366)3.23695395
29Increased serum pyruvate (HP:0003542)3.23695395
30Abnormality of the intrinsic pathway (HP:0010989)3.21826813
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.17595863
32Epidermoid cyst (HP:0200040)3.17161394
33Recurrent gram-negative bacterial infections (HP:0005420)3.16449687
34Anomalous pulmonary venous return (HP:0010772)3.16122485
35Amyloidosis (HP:0011034)2.99937246
36Mitral stenosis (HP:0001718)2.99801818
37Fat malabsorption (HP:0002630)2.98886217
38Gingival bleeding (HP:0000225)2.97950753
39Hyperinsulinemic hypoglycemia (HP:0000825)2.97372566
40Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.97151456
41Hypolipoproteinemia (HP:0010981)2.95806117
42Cerebral inclusion bodies (HP:0100314)2.93752270
43Abnormality of sulfur amino acid metabolism (HP:0004339)2.91469400
44Hyperglycinuria (HP:0003108)2.88282977
45Ketosis (HP:0001946)2.86471598
46Spastic paraparesis (HP:0002313)2.86327272
47Vacuolated lymphocytes (HP:0001922)2.80325340
48Hyperglycinemia (HP:0002154)2.79594482
49Spastic tetraparesis (HP:0001285)2.77799483
50Abnormality of nucleobase metabolism (HP:0010932)2.76900099
51Hyperventilation (HP:0002883)2.74217382
52Abnormality of the common coagulation pathway (HP:0010990)2.72415963
53Partial duplication of thumb phalanx (HP:0009944)2.72156426
54Hydroxyprolinuria (HP:0003080)2.70848754
55Abnormality of proline metabolism (HP:0010907)2.70848754
56Hypoalphalipoproteinemia (HP:0003233)2.68283684
57Skin nodule (HP:0200036)2.68041713
58Abnormality of the pulmonary veins (HP:0011718)2.67126173
59Hepatoblastoma (HP:0002884)2.64774947
60Abnormality of complement system (HP:0005339)2.55204953
61Hypercholesterolemia (HP:0003124)2.53058544
62Abnormality of the lower motor neuron (HP:0002366)2.52288406
63J-shaped sella turcica (HP:0002680)2.50474971
64Cerebral hypomyelination (HP:0006808)2.45395582
65Epistaxis (HP:0000421)2.44873118
66Steatorrhea (HP:0002570)2.44693860
67Pulmonary embolism (HP:0002204)2.42505797
68Delayed CNS myelination (HP:0002188)2.42202644
69Late onset (HP:0003584)2.42041061
70Onion bulb formation (HP:0003383)2.41897699
71Cardiovascular calcification (HP:0011915)2.40056330
72Abnormality of glutamine family amino acid metabolism (HP:0010902)2.39785383
73Malnutrition (HP:0004395)2.38761740
74Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.34846266
75Generalized aminoaciduria (HP:0002909)2.32803921
76Myocardial infarction (HP:0001658)2.27906674
77Partial duplication of the phalanx of hand (HP:0009999)2.26856273
78Spontaneous abortion (HP:0005268)2.26217054
79Impaired platelet aggregation (HP:0003540)2.24298520
80Abnormal platelet function (HP:0011869)2.24298520
81Cholecystitis (HP:0001082)2.23931090
82Abnormal gallbladder physiology (HP:0012438)2.23931090
83Abnormal gallbladder morphology (HP:0012437)2.22798430
84Hepatocellular carcinoma (HP:0001402)2.22466977
85Mucopolysacchariduria (HP:0008155)2.22275863
86Urinary glycosaminoglycan excretion (HP:0003541)2.22275863
87Rickets (HP:0002748)2.21904909
88Thrombophlebitis (HP:0004418)2.21770766
89Irritability (HP:0000737)2.20995790
903-Methylglutaconic aciduria (HP:0003535)2.18431034
91Abnormality of the salivary glands (HP:0010286)2.15166699
92Intention tremor (HP:0002080)2.14642479
93Abnormality of pyrimidine metabolism (HP:0004353)2.14381185
94Parakeratosis (HP:0001036)2.14020979
95Abnormal cartilage morphology (HP:0002763)2.12611537
96Hyperbilirubinemia (HP:0002904)2.11468333
97Dysostosis multiplex (HP:0000943)2.11375438
98Abnormality of mucopolysaccharide metabolism (HP:0011020)2.11018877
99Abnormality of polysaccharide metabolism (HP:0011012)2.11018877
100Abnormality of glycosaminoglycan metabolism (HP:0004371)2.11018877
101Paraparesis (HP:0002385)2.09352252
102Conjugated hyperbilirubinemia (HP:0002908)2.09245181
103Abnormality of the Achilles tendon (HP:0005109)2.07935826
104Spastic gait (HP:0002064)2.05862661
105Abnormality of fatty-acid metabolism (HP:0004359)2.04236418
106Abnormal auditory evoked potentials (HP:0006958)2.03199061
107Decreased central vision (HP:0007663)2.03051478
108Gangrene (HP:0100758)2.02702336
109Vascular calcification (HP:0004934)2.01669074
110Ketoacidosis (HP:0001993)2.00674926
111Metabolic acidosis (HP:0001942)1.99265214
112Cholelithiasis (HP:0001081)1.99000418
113Pancreatic islet-cell hyperplasia (HP:0004510)1.98147451
114Increased serum ferritin (HP:0003281)1.95425746
115Infantile muscular hypotonia (HP:0008947)1.94786945
116Peripheral demyelination (HP:0011096)1.94366462
117Abnormality of serum amino acid levels (HP:0003112)1.93869117
118Hypophosphatemic rickets (HP:0004912)1.93469319
119Hypoglycemic coma (HP:0001325)1.93469068
120Fair hair (HP:0002286)1.93331423
121Abnormal biliary tract physiology (HP:0012439)1.92495017
122Bile duct proliferation (HP:0001408)1.92495017
123Gout (HP:0001997)1.90744839
124Morphological abnormality of the pyramidal tract (HP:0002062)1.90408899
125Multiple enchondromatosis (HP:0005701)1.90343442
126Peripheral hypomyelination (HP:0007182)1.87789235
127Lethargy (HP:0001254)1.87781661
128Arthropathy (HP:0003040)1.87017501
129Progressive external ophthalmoplegia (HP:0000590)1.86733992
130Generalized hypopigmentation of hair (HP:0011358)1.86665136
131Dicarboxylic aciduria (HP:0003215)1.86430409
132Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86430409
133Ragged-red muscle fibers (HP:0003200)1.81097834
134Panhypogammaglobulinemia (HP:0003139)1.79748150
135Enlarged kidneys (HP:0000105)1.79549674
136Tetraplegia (HP:0002445)1.78717468
137Bifid scrotum (HP:0000048)1.78572360
138Axonal loss (HP:0003447)1.78343224
139Abnormal enzyme/coenzyme activity (HP:0012379)1.77982130
140Increased mean platelet volume (HP:0011877)1.76063806
141Abnormality of glycolipid metabolism (HP:0010969)1.70361527
142Abnormality of liposaccharide metabolism (HP:0010968)1.70361527
143Abnormality of glycosphingolipid metabolism (HP:0004343)1.70361527
144Abnormality of iron homeostasis (HP:0011031)1.69812585
145Abnormality of purine metabolism (HP:0004352)1.68114820
146Nonimmune hydrops fetalis (HP:0001790)1.68025136
147Increased neuronal autofluorescent lipopigment (HP:0002074)1.64075206
148Retinal atrophy (HP:0001105)1.63007496
149Osteomalacia (HP:0002749)1.62889190
150Reticulocytosis (HP:0001923)1.62329303
151Prolonged bleeding time (HP:0003010)1.60200880
152Abnormality of transition element cation homeostasis (HP:0011030)1.59026159
153Joint swelling (HP:0001386)1.58559717
154Reduced antithrombin III activity (HP:0001976)1.55034459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK24.58594087
2STK394.48702895
3ERN13.45491515
4GRK53.42887718
5CDK123.36370376
6EPHB13.18048613
7GRK13.09498424
8OXSR13.03675092
9IRAK33.00478573
10GRK62.83553255
11PKN12.69155013
12PIM22.67548961
13FGFR32.50464668
14ADRBK22.49543999
15TYRO32.41103956
16MAP3K32.34396976
17NTRK12.29188420
18TBK12.29074144
19WNK12.25409688
20ARAF2.14975494
21BCKDK2.10610573
22CSF1R1.97360914
23TESK21.92858067
24MET1.92302448
25MAPK71.90236261
26PBK1.87309475
27FGFR21.81422924
28EIF2AK31.81210490
29GRK71.69741462
30BCR1.68817925
31IKBKB1.64865693
32ICK1.61515533
33ERBB41.60320029
34MAP3K141.56636915
35FRK1.56063809
36TIE11.53794721
37WNK41.52084125
38TAOK21.51884520
39TEC1.50668466
40MAP4K11.44279713
41SYK1.37666454
42MAP3K11.37643478
43MARK21.32985339
44IKBKE1.25957157
45SIK11.24964759
46TXK1.23316347
47NEK91.20023886
48MAP2K71.17798834
49CSNK1G31.16805893
50NME21.16502284
51PINK11.16286462
52UHMK11.14240331
53PRPF4B1.11883625
54MOS1.11847025
55MAP2K41.11764388
56TGFBR21.09133776
57PTK2B1.09013765
58CSNK1A1L1.08197135
59PKN21.08130294
60MAPKAPK51.07555597
61FGFR41.05768296
62KDR1.02180653
63MATK1.01012947
64BMPR1B0.95544873
65DYRK20.93761211
66CDK190.93092559
67TNIK0.92808473
68IRAK20.90252730
69RPS6KL10.90210459
70RPS6KC10.90210459
71RPS6KA60.90207363
72CSNK1G10.89875983
73FGR0.85672582
74CAMK2B0.84384952
75CAMK2G0.83830572
76GSK3A0.80203563
77TAOK10.80154916
78DYRK1B0.79447624
79ROCK20.79239257
80TYK20.79044391
81LIMK10.78754304
82CHUK0.78620369
83LMTK20.78209288
84DYRK1A0.77313830
85RIPK40.76981634
86MAPK120.76128850
87FER0.75961260
88CSNK1G20.75898201
89CSK0.75881740
90CAMK40.75308841
91PRKG20.74563335
92PAK60.74428995
93MAP3K70.74213153
94STK100.73752830
95MAP3K40.72761119
96PAK30.72109043
97NTRK30.70060418
98NEK60.67885255
99DAPK20.66768799
100KIT0.64727603
101CAMK2D0.64151829
102TTK0.63635118
103PRKCQ0.63414512
104ADRBK10.62542304
105MAP4K20.61246963
106LYN0.60938322
107ABL20.60853419
108INSRR0.60584351
109PRKD10.60185281
110PTK20.57699110
111ERBB20.56652516
112MUSK0.54463049
113SGK4940.54308842
114SGK2230.54308842
115STK380.54262344
116ITK0.53779177
117MAPK150.52405448
118PRKCE0.52382240
119TAOK30.51931932
120PRKCG0.51341685
121PIK3CA0.50898594
122HIPK20.50704924
123IRAK10.50459748
124MAP3K100.50372892
125MAPK110.49328848
126PDPK10.47978401
127MAP2K30.47681645
128AKT20.47461305
129MAPKAPK30.47404249
130RPS6KB10.46191664
131CLK10.45743203
132EPHA40.45620042
133MAP3K50.44404912
134IRAK40.43942368
135BMPR20.43877663
136PRKACG0.43648405
137NLK0.43340902
138BMX0.43106626
139DDR20.43020936
140BLK0.42895989
141EPHA30.42809363
142ABL10.42258096
143MAP3K110.41773842
144CAMK2A0.40885827
145PRKACB0.39948106
146MAPK40.39621197
147MAPK30.37873877
148CSNK1E0.37578427
149PIK3CG0.37243812
150FYN0.37238370
151IGF1R0.37073276
152RAF10.36954787
153RPS6KB20.36299167
154CDK150.35749281
155CDK140.35484904
156DAPK30.35157540
157CSNK1A10.34538236
158PRKACA0.34357274
159CASK0.33170768
160MAP2K60.32861418
161INSR0.32779458
162PRKAA20.32092205
163PRKCZ0.31892871
164PDK10.31874637
165MST1R0.31835361
166EPHA20.31651735
167CSNK1D0.31275584

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.63880436
2Nitrogen metabolism_Homo sapiens_hsa009103.42682855
3Vitamin B6 metabolism_Homo sapiens_hsa007503.34555691
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.15617456
5Steroid biosynthesis_Homo sapiens_hsa001002.97762124
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.79585524
7Fatty acid elongation_Homo sapiens_hsa000622.68824733
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.67246685
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.50442671
10Complement and coagulation cascades_Homo sapiens_hsa046102.43773416
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.37555375
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37242470
13Arginine biosynthesis_Homo sapiens_hsa002202.34030518
14Tryptophan metabolism_Homo sapiens_hsa003802.31220855
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.23636960
16Butanoate metabolism_Homo sapiens_hsa006502.19620911
17Histidine metabolism_Homo sapiens_hsa003402.12206796
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.11905572
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.10888179
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.01526255
21Chemical carcinogenesis_Homo sapiens_hsa052041.94358223
22Peroxisome_Homo sapiens_hsa041461.88664277
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.87994563
24Fatty acid degradation_Homo sapiens_hsa000711.81100582
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.78984862
26Sulfur metabolism_Homo sapiens_hsa009201.78087565
27Fatty acid metabolism_Homo sapiens_hsa012121.68763183
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61264356
29Propanoate metabolism_Homo sapiens_hsa006401.57409967
30Retinol metabolism_Homo sapiens_hsa008301.57361047
31PPAR signaling pathway_Homo sapiens_hsa033201.52895181
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51734394
33Other glycan degradation_Homo sapiens_hsa005111.47201830
34Linoleic acid metabolism_Homo sapiens_hsa005911.46233636
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41014448
36beta-Alanine metabolism_Homo sapiens_hsa004101.37639374
37Tyrosine metabolism_Homo sapiens_hsa003501.31299290
38Folate biosynthesis_Homo sapiens_hsa007901.30438465
39Ether lipid metabolism_Homo sapiens_hsa005651.27648613
40Staphylococcus aureus infection_Homo sapiens_hsa051501.25092221
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24030825
42Caffeine metabolism_Homo sapiens_hsa002321.22086175
43Arginine and proline metabolism_Homo sapiens_hsa003301.21157746
44Bile secretion_Homo sapiens_hsa049761.20806370
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15830101
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.14018447
47Phenylalanine metabolism_Homo sapiens_hsa003601.12839853
48Pyruvate metabolism_Homo sapiens_hsa006201.07103366
49Selenocompound metabolism_Homo sapiens_hsa004501.05096420
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.03337821
51ABC transporters_Homo sapiens_hsa020100.99543648
52Fat digestion and absorption_Homo sapiens_hsa049750.98421609
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.92154704
54Glutathione metabolism_Homo sapiens_hsa004800.90512506
55Arachidonic acid metabolism_Homo sapiens_hsa005900.90467814
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83892781
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82823206
58Biosynthesis of amino acids_Homo sapiens_hsa012300.82068578
59Starch and sucrose metabolism_Homo sapiens_hsa005000.79007327
60Sulfur relay system_Homo sapiens_hsa041220.77880355
61Vitamin digestion and absorption_Homo sapiens_hsa049770.76460623
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75929726
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.75165105
64Carbon metabolism_Homo sapiens_hsa012000.75107811
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75077253
66Pertussis_Homo sapiens_hsa051330.73175125
67Glycerolipid metabolism_Homo sapiens_hsa005610.66206518
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.65663842
69Metabolic pathways_Homo sapiens_hsa011000.60312044
70Fructose and mannose metabolism_Homo sapiens_hsa000510.59799716
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.58609648
72Systemic lupus erythematosus_Homo sapiens_hsa053220.50345719
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47694782
74Fatty acid biosynthesis_Homo sapiens_hsa000610.47480547
75Ovarian steroidogenesis_Homo sapiens_hsa049130.45961505
76Pentose phosphate pathway_Homo sapiens_hsa000300.45509720
77Lysine degradation_Homo sapiens_hsa003100.44873511
78Prion diseases_Homo sapiens_hsa050200.35691134
79Insulin resistance_Homo sapiens_hsa049310.29455132
80Axon guidance_Homo sapiens_hsa043600.29049055
81Lysosome_Homo sapiens_hsa041420.28926799
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28352463
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.27274279
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27198391
85Primary immunodeficiency_Homo sapiens_hsa053400.26973952
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.23780771
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21488360
88Galactose metabolism_Homo sapiens_hsa000520.19957270
89* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18532681
90Asthma_Homo sapiens_hsa053100.15652256
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.14996635
92Sphingolipid metabolism_Homo sapiens_hsa006000.14256970
93Rheumatoid arthritis_Homo sapiens_hsa053230.13527033
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13187901
95Allograft rejection_Homo sapiens_hsa053300.12075464
96Oxidative phosphorylation_Homo sapiens_hsa001900.11363129
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10999390
98One carbon pool by folate_Homo sapiens_hsa006700.09851580
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05611832
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.05266103
101Graft-versus-host disease_Homo sapiens_hsa053320.04026745
102Malaria_Homo sapiens_hsa051440.03732710
103Amoebiasis_Homo sapiens_hsa051460.03690456
104Renin-angiotensin system_Homo sapiens_hsa046140.03323945
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.01781067
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.01587843
107Sphingolipid signaling pathway_Homo sapiens_hsa04071-0.1040294
108AMPK signaling pathway_Homo sapiens_hsa04152-0.0977494
109Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0945496
110Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0876348
111Ras signaling pathway_Homo sapiens_hsa04014-0.0845671
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0815145
113Serotonergic synapse_Homo sapiens_hsa04726-0.0574601
114Protein export_Homo sapiens_hsa03060-0.0539515
115Glutamatergic synapse_Homo sapiens_hsa04724-0.0460787
116Alzheimers disease_Homo sapiens_hsa05010-0.0408742
117TNF signaling pathway_Homo sapiens_hsa04668-0.0340302
118Glucagon signaling pathway_Homo sapiens_hsa04922-0.0337380
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0290197
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0225513
121Regulation of autophagy_Homo sapiens_hsa04140-0.0209841
122Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0204105
123GABAergic synapse_Homo sapiens_hsa04727-0.0142637
124African trypanosomiasis_Homo sapiens_hsa05143-0.0093780
125Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0091829
126Mineral absorption_Homo sapiens_hsa04978-0.0069986

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