CLDN15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)9.08742147
2angiotensin maturation (GO:0002003)8.94917414
3intestinal cholesterol absorption (GO:0030299)7.47164961
4killing of cells of other organism (GO:0031640)6.78539701
5disruption of cells of other organism (GO:0044364)6.78539701
6defense response to fungus (GO:0050832)6.55230872
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.03773138
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.03655598
9regulation of guanylate cyclase activity (GO:0031282)5.94308176
10antigen processing and presentation of endogenous antigen (GO:0019883)5.90177213
11response to fungus (GO:0009620)5.40331003
12fat-soluble vitamin biosynthetic process (GO:0042362)5.36059705
13epoxygenase P450 pathway (GO:0019373)5.31096429
14glucose 6-phosphate metabolic process (GO:0051156)5.26932538
15killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.18267572
16disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.18267572
17peptide catabolic process (GO:0043171)4.89354864
18regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.88056295
19flavonoid metabolic process (GO:0009812)4.75081747
20vitamin A metabolic process (GO:0006776)4.74380543
21regulation of triglyceride catabolic process (GO:0010896)4.73943754
22actin filament depolymerization (GO:0030042)4.72511691
23UDP-N-acetylglucosamine metabolic process (GO:0006047)4.64565351
24positive regulation of lipoprotein lipase activity (GO:0051006)4.47132800
25positive regulation of triglyceride lipase activity (GO:0061365)4.47132800
26positive regulation of guanylate cyclase activity (GO:0031284)4.42068182
27digestive system process (GO:0022600)4.36055758
28urea cycle (GO:0000050)4.33229183
29NADH metabolic process (GO:0006734)4.32569996
30urea metabolic process (GO:0019627)4.20179814
31drug metabolic process (GO:0017144)4.16257174
32neutrophil mediated immunity (GO:0002446)4.10438625
33regulation of systemic arterial blood pressure by hormone (GO:0001990)4.08503164
34regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.08503164
35endocrine process (GO:0050886)4.08503164
36alkaloid metabolic process (GO:0009820)4.06852449
37negative regulation of phagocytosis (GO:0050765)4.06188951
38regulation of respiratory burst (GO:0060263)4.03721135
39pentose-phosphate shunt (GO:0006098)4.00368185
40modulation of growth of symbiont involved in interaction with host (GO:0044144)3.99599371
41regulation of growth of symbiont in host (GO:0044126)3.99599371
42negative regulation of growth of symbiont in host (GO:0044130)3.99599371
43negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.99599371
44nitrogen cycle metabolic process (GO:0071941)3.97005453
45regulation of cellular extravasation (GO:0002691)3.96292450
46triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.95779007
47NADPH regeneration (GO:0006740)3.91374024
48adhesion of symbiont to host cell (GO:0044650)3.90625681
49virion attachment to host cell (GO:0019062)3.90625681
50hydrogen peroxide catabolic process (GO:0042744)3.81117266
51purine nucleotide salvage (GO:0032261)3.80369250
52transcytosis (GO:0045056)3.77818767
53leukotriene biosynthetic process (GO:0019370)3.72353373
54regulation of systemic arterial blood pressure (GO:0003073)3.69342824
55adhesion of symbiont to host (GO:0044406)3.68634163
56receptor guanylyl cyclase signaling pathway (GO:0007168)3.67409763
57regulation of dendritic cell antigen processing and presentation (GO:0002604)3.67095300
58response to hydroperoxide (GO:0033194)3.66394314
59regulation of cGMP biosynthetic process (GO:0030826)3.65137516
60plasma lipoprotein particle assembly (GO:0034377)3.62055162
61drug catabolic process (GO:0042737)3.61914225
62diacylglycerol metabolic process (GO:0046339)3.60426047
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.41342689
64bile acid and bile salt transport (GO:0015721)3.40849581
65protein-lipid complex assembly (GO:0065005)3.39443911
66phospholipid efflux (GO:0033700)3.37877899
67antibacterial humoral response (GO:0019731)3.33738643
68lipoprotein metabolic process (GO:0042157)3.32815949
69low-density lipoprotein particle clearance (GO:0034383)3.27647900
70antimicrobial humoral response (GO:0019730)3.25699297
71positive regulation of triglyceride metabolic process (GO:0090208)3.24816699
72purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.23784323
733-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.23784323
74negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.22407298
75negative regulation of cell killing (GO:0031342)3.22407298
76arginine metabolic process (GO:0006525)3.20931807
77hormone catabolic process (GO:0042447)3.20923266
78cellular response to hepatocyte growth factor stimulus (GO:0035729)3.20572321
79response to hepatocyte growth factor (GO:0035728)3.20572321
80cell killing (GO:0001906)3.19399890
81modified amino acid transport (GO:0072337)3.18929953
82leukotriene metabolic process (GO:0006691)3.18894955
83positive regulation of pseudopodium assembly (GO:0031274)3.15031717
84very-low-density lipoprotein particle assembly (GO:0034379)3.14895619
85vitamin transmembrane transport (GO:0035461)3.12714251
86positive regulation of antigen processing and presentation (GO:0002579)3.10712248
87plasma lipoprotein particle organization (GO:0071827)3.09189942
88regulation of vitamin metabolic process (GO:0030656)3.08633286
89myeloid leukocyte mediated immunity (GO:0002444)3.07766481
90detection of bacterium (GO:0016045)3.07236923
91maintenance of gastrointestinal epithelium (GO:0030277)3.05022349
92regulation of cGMP metabolic process (GO:0030823)3.04804055
93peptide hormone processing (GO:0016486)3.04124715
94plasma lipoprotein particle remodeling (GO:0034369)3.03982866
95protein-lipid complex remodeling (GO:0034368)3.03982866
96macromolecular complex remodeling (GO:0034367)3.03982866
97intestinal epithelial cell development (GO:0060576)3.02674736
98bundle of His cell to Purkinje myocyte communication (GO:0086069)3.01750653
99regulation of cholesterol esterification (GO:0010872)3.01243304
100positive regulation of fatty acid biosynthetic process (GO:0045723)3.00197373
101protein-lipid complex subunit organization (GO:0071825)2.99471488
102immunoglobulin mediated immune response (GO:0016064)2.99163090
103glucose catabolic process (GO:0006007)2.98694321
104sterol homeostasis (GO:0055092)2.98324927
105cholesterol homeostasis (GO:0042632)2.97787737
106primary alcohol catabolic process (GO:0034310)2.97425752
107cellular response to oxygen radical (GO:0071450)2.95258609
108removal of superoxide radicals (GO:0019430)2.95258609
109cellular response to superoxide (GO:0071451)2.95258609
110hydrogen peroxide metabolic process (GO:0042743)2.91967637
111hepatocyte apoptotic process (GO:0097284)2.90255593
112homocysteine metabolic process (GO:0050667)2.90088469
113positive regulation of gamma-delta T cell activation (GO:0046645)2.89904691
114mitochondrial calcium ion transport (GO:0006851)2.89899357
115innate immune response in mucosa (GO:0002227)2.89496695
116negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.89200424
117digestion (GO:0007586)2.88928562
118ethanol metabolic process (GO:0006067)2.88769249
119vitamin transport (GO:0051180)2.88183970
120regulation of hydrogen peroxide metabolic process (GO:0010310)2.88161808
121sulfate transmembrane transport (GO:1902358)2.87486289
122phospholipid scrambling (GO:0017121)2.86843358
123sperm capacitation (GO:0048240)2.86702194
124regulation of bile acid biosynthetic process (GO:0070857)2.85333840
125cellular response to nitric oxide (GO:0071732)2.85191702
126glycolipid catabolic process (GO:0019377)2.83894560
127sulfation (GO:0051923)2.83672882
128glycosphingolipid catabolic process (GO:0046479)2.83081359
129detection of other organism (GO:0098543)2.82826224
130negative regulation of erythrocyte differentiation (GO:0045647)2.82784433
131regulation of antigen processing and presentation (GO:0002577)2.82728171
132pentose metabolic process (GO:0019321)2.81647758
133response to nitric oxide (GO:0071731)2.81310708
134positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.81287900
135phenylpropanoid metabolic process (GO:0009698)2.80880143
136renal system process involved in regulation of blood volume (GO:0001977)2.80825889
137drinking behavior (GO:0042756)2.79244358
138exogenous drug catabolic process (GO:0042738)2.79049874
139NIK/NF-kappaB signaling (GO:0038061)2.78137019
140lipoprotein transport (GO:0042953)2.77862204
141hexose catabolic process (GO:0019320)2.76926453
142GDP-mannose metabolic process (GO:0019673)2.76893867
143cellular response to reactive nitrogen species (GO:1902170)2.76585784
144fructose metabolic process (GO:0006000)2.75951683
145positive regulation of respiratory burst (GO:0060267)2.75532393
146glutamine family amino acid biosynthetic process (GO:0009084)2.75196625
147L-ascorbic acid metabolic process (GO:0019852)2.74721457
148phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.74146147
149regulation of pseudopodium assembly (GO:0031272)2.72967516
150positive regulation of lipid catabolic process (GO:0050996)2.72236331
151cellular response to zinc ion (GO:0071294)2.72008192
152proline biosynthetic process (GO:0006561)2.71899302
153tricarboxylic acid cycle (GO:0006099)2.71091400
154ethanol oxidation (GO:0006069)2.69096698
155glucuronate metabolic process (GO:0019585)2.67642411
156uronic acid metabolic process (GO:0006063)2.67642411
157bile acid metabolic process (GO:0008206)2.67283191
158regulation of gamma-delta T cell differentiation (GO:0045586)2.65178151
159cellular glucuronidation (GO:0052695)2.64567866
160drug transport (GO:0015893)2.63423819
161positive thymic T cell selection (GO:0045059)2.61524800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.98869833
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.95072612
3CDX2_20551321_ChIP-Seq_CACO-2_Human4.24385622
4E2F7_22180533_ChIP-Seq_HELA_Human3.43276634
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.40825299
6* HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.18890417
7SOX2_27498859_Chip-Seq_STOMACH_Mouse2.95856155
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.94369770
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.74533357
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.68415719
11GATA4_25053715_ChIP-Seq_YYC3_Human2.61897486
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.55606050
13STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.28859027
14GATA6_25053715_ChIP-Seq_YYC3_Human2.25659576
15AR_21909140_ChIP-Seq_LNCAP_Human2.20254265
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.17511155
17SOX2_20726797_ChIP-Seq_SW620_Human2.13124033
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12945528
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05389781
20MYC_22102868_ChIP-Seq_BL_Human2.01706186
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95812157
22VDR_21846776_ChIP-Seq_THP-1_Human1.90228463
23RXR_22158963_ChIP-Seq_LIVER_Mouse1.88223346
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86293150
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80796963
26LXR_22158963_ChIP-Seq_LIVER_Mouse1.79275280
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75551553
28TET1_21451524_ChIP-Seq_MESCs_Mouse1.70617813
29GATA1_22025678_ChIP-Seq_K562_Human1.70150406
30CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.70011741
31MAF_26560356_Chip-Seq_TH1_Human1.65531371
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.64810333
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64707485
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63282980
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61994879
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61417327
37TCF7_22412390_ChIP-Seq_EML_Mouse1.59967123
38CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.59477797
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58702229
40VDR_24763502_ChIP-Seq_THP-1_Human1.58072589
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.55677879
42SA1_27219007_Chip-Seq_Bcells_Human1.53255089
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52719115
44CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52631223
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51924421
46GATA1_19941826_ChIP-Seq_K562_Human1.50131650
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47837194
48SA1_27219007_Chip-Seq_ERYTHROID_Human1.45627085
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.45598371
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44787199
51MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44617825
52CLOCK_20551151_ChIP-Seq_293T_Human1.43885320
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43071840
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41646719
55KDM2B_26808549_Chip-Seq_DND41_Human1.40471058
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40158337
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38503645
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.37889324
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37686137
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37460772
61PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.37373525
62MAF_26560356_Chip-Seq_TH2_Human1.35987425
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35303397
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.35243011
65E2F1_20622854_ChIP-Seq_HELA_Human1.34205968
66PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31633844
67SCL_19346495_ChIP-Seq_HPC-7_Human1.31371839
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31338214
69MYB_26560356_Chip-Seq_TH1_Human1.31327191
70BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.30484963
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28912427
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28862363
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28539678
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.27497389
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27198569
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27193338
77SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24920517
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23848907
79ATF3_27146783_Chip-Seq_COLON_Human1.23704792
80* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23266550
81MYB_26560356_Chip-Seq_TH2_Human1.22862418
82YY1_22570637_ChIP-Seq_MALME-3M_Human1.22828152
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22297294
84SPI1_23547873_ChIP-Seq_NB4_Human1.21809843
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21119050
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20961867
87RACK7_27058665_Chip-Seq_MCF-7_Human1.20793644
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20118817
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19737184
90NCOR1_26117541_ChIP-Seq_K562_Human1.18523136
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17926167
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17809770
93RUNX_20019798_ChIP-Seq_JUKART_Human1.17664834
94CTCF_27219007_Chip-Seq_Bcells_Human1.16659088
95CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16266582
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15295917
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13280251
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13119614
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12315513
100IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10874307
101IRF8_27001747_Chip-Seq_BMDM_Mouse1.10848081
102JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.10606352
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10390744
104RUNX1_22412390_ChIP-Seq_EML_Mouse1.09886416
105* CTCF_26484167_Chip-Seq_Bcells_Mouse1.09610814
106CTCF_20526341_ChIP-Seq_ESCs_Human1.09334421
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09258570
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08608710
109BCL6_27268052_Chip-Seq_Bcells_Human1.08589697
110STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08519416
111* CREB1_26743006_Chip-Seq_LNCaP_Human1.08386336
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03569944
113SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03094878
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02858366
115* GATA2_19941826_ChIP-Seq_K562_Human1.01589801
116GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01148563
117HNF4A_19822575_ChIP-Seq_HepG2_Human0.99600553
118RUNX1_27514584_Chip-Seq_MCF-7_Human0.99423784
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97066453
120IRF8_21731497_ChIP-ChIP_J774_Mouse0.96411461
121P300_27268052_Chip-Seq_Bcells_Human0.96104588
122LXR_22292898_ChIP-Seq_THP-1_Human0.95972745
123CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95385344
124KLF5_25053715_ChIP-Seq_YYC3_Human0.94538063
125UTX_26944678_Chip-Seq_JUKART_Human0.94113886
126LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94085656
127NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93501870
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91052036
129PHF8_20622854_ChIP-Seq_HELA_Human0.90430676
130STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89419848
131HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88380973
132BCOR_27268052_Chip-Seq_Bcells_Human0.88294974
133LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88240752
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88027685
135P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87613550
136NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87548362
137CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85350393
138MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.84789791
139TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84162011
140FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83147654
141FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82933779
142NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.82312153
143GATA2_21666600_ChIP-Seq_HMVEC_Human0.82129674
144CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81848821
145YY1_21170310_ChIP-Seq_MESCs_Mouse0.81312443
146STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80984626
147SPI1_23127762_ChIP-Seq_K562_Human0.79371774
148SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79093651
149SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79093651
150ESR1_20079471_ChIP-ChIP_T-47D_Human0.78329822
151CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78233887
152SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78125222
153P68_20966046_ChIP-Seq_HELA_Human0.77640805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.32248662
2MP0001666_abnormal_nutrient_absorption4.49631594
3MP0004264_abnormal_extraembryonic_tissu3.94806169
4MP0003183_abnormal_peptide_metabolism3.27462913
5MP0009840_abnormal_foam_cell2.97719541
6MP0003866_abnormal_defecation2.94464634
7MP0010234_abnormal_vibrissa_follicle2.93387385
8MP0006054_spinal_hemorrhage2.56162704
9MP0010329_abnormal_lipoprotein_level2.53528266
10MP0002139_abnormal_hepatobiliary_system2.53446631
11MP0001873_stomach_inflammation2.51684070
12MP0001835_abnormal_antigen_presentation2.33919668
13* MP0010155_abnormal_intestine_physiology2.32059928
14MP0002138_abnormal_hepatobiliary_system2.30524695
15MP0003724_increased_susceptibility_to2.19430510
16* MP0000490_abnormal_crypts_of2.18576492
17MP0005085_abnormal_gallbladder_physiolo2.10361493
18MP0003300_gastrointestinal_ulcer2.10049728
19MP0009379_abnormal_foot_pigmentation2.08753393
20MP0003252_abnormal_bile_duct2.07810922
21* MP0001663_abnormal_digestive_system2.05677171
22MP0000537_abnormal_urethra_morphology1.92815828
23MP0010352_gastrointestinal_tract_polyps1.92653964
24MP0003693_abnormal_embryo_hatching1.90646176
25MP0008875_abnormal_xenobiotic_pharmacok1.88774383
26MP0004147_increased_porphyrin_level1.83576631
27* MP0005381_digestive/alimentary_phenotyp1.81236461
28MP0003303_peritoneal_inflammation1.72859344
29MP0008004_abnormal_stomach_pH1.72004839
30* MP0000462_abnormal_digestive_system1.65736223
31* MP0000477_abnormal_intestine_morphology1.62665342
32MP0005387_immune_system_phenotype1.60034115
33MP0001790_abnormal_immune_system1.60034115
34MP0003191_abnormal_cellular_cholesterol1.57939030
35MP0000685_abnormal_immune_system1.56408959
36MP0001800_abnormal_humoral_immune1.50236064
37MP0009785_altered_susceptibility_to1.47098327
38MP0004019_abnormal_vitamin_homeostasis1.44974186
39MP0005671_abnormal_response_to1.44375134
40MP0009643_abnormal_urine_homeostasis1.44125274
41MP0003868_abnormal_feces_composition1.42531687
42MP0001664_abnormal_digestion1.38013540
43MP0005451_abnormal_body_composition1.35864889
44MP0005365_abnormal_bile_salt1.34892129
45MP0005000_abnormal_immune_tolerance1.34571990
46MP0005084_abnormal_gallbladder_morpholo1.32873002
47MP0005448_abnormal_energy_balance1.31831809
48MP0005058_abnormal_lysosome_morphology1.31559746
49MP0004858_abnormal_nervous_system1.30858445
50MP0005409_darkened_coat_color1.29453242
51MP0001764_abnormal_homeostasis1.27747242
52MP0000678_abnormal_parathyroid_gland1.25466293
53MP0002723_abnormal_immune_serum1.25280240
54MP0002166_altered_tumor_susceptibility1.24424738
55MP0002396_abnormal_hematopoietic_system1.23346280
56MP0002089_abnormal_postnatal_growth/wei1.23148584
57MP0005167_abnormal_blood-brain_barrier1.23137229
58MP0001819_abnormal_immune_cell1.20575249
59MP0002420_abnormal_adaptive_immunity1.19696931
60MP0004185_abnormal_adipocyte_glucose1.19469733
61MP0003436_decreased_susceptibility_to1.18388524
62MP0002452_abnormal_antigen_presenting1.18373487
63MP0003763_abnormal_thymus_physiology1.18354311
64MP0008469_abnormal_protein_level1.17802826
65MP0005670_abnormal_white_adipose1.17708385
66MP0005666_abnormal_adipose_tissue1.15023713
67MP0003705_abnormal_hypodermis_morpholog1.12213123
68MP0005535_abnormal_body_temperature1.09796368
69MP0004043_abnormal_pH_regulation1.09662695
70MP0009115_abnormal_fat_cell1.09297339
71MP0000538_abnormal_urinary_bladder1.09128968
72MP0002118_abnormal_lipid_homeostasis1.08432390
73MP0005025_abnormal_response_to1.00319604
74MP0009697_abnormal_copulation0.98627395
75MP0000858_altered_metastatic_potential0.98448802
76MP0003879_abnormal_hair_cell0.98353713
77MP0000609_abnormal_liver_physiology0.98313218
78MP0002132_abnormal_respiratory_system0.97470285
79MP0002006_tumorigenesis0.96713798
80MP0000716_abnormal_immune_system0.96594779
81MP0002419_abnormal_innate_immunity0.96529086
82MP0001845_abnormal_inflammatory_respons0.96266622
83MP0009764_decreased_sensitivity_to0.96221026
84MP0002971_abnormal_brown_adipose0.96204857
85MP0005377_hearing/vestibular/ear_phenot0.95912085
86MP0003878_abnormal_ear_physiology0.95912085
87MP0003172_abnormal_lysosome_physiology0.94334481
88MP0002796_impaired_skin_barrier0.93873639
89MP0005332_abnormal_amino_acid0.92934225
90MP0005174_abnormal_tail_pigmentation0.92001674
91MP0001533_abnormal_skeleton_physiology0.91983638
92MP0006082_CNS_inflammation0.91514868
93MP0004947_skin_inflammation0.90965218
94MP0002876_abnormal_thyroid_physiology0.86839133
95MP0005319_abnormal_enzyme/_coenzyme0.86827793
96MP0002148_abnormal_hypersensitivity_rea0.86031813
97MP0003718_maternal_effect0.85984408
98MP0005310_abnormal_salivary_gland0.84777115
99MP0005266_abnormal_metabolism0.84673691
100MP0005376_homeostasis/metabolism_phenot0.83969685
101MP0002398_abnormal_bone_marrow0.83825943
102MP0008260_abnormal_autophagy0.83137134
103MP0001501_abnormal_sleep_pattern0.82971227
104MP0001765_abnormal_ion_homeostasis0.82893917
105MP0000249_abnormal_blood_vessel0.82550922
106MP0005164_abnormal_response_to0.82333999
107MP0003828_pulmonary_edema0.81253187
108MP0004782_abnormal_surfactant_physiolog0.81183936
109MP0004130_abnormal_muscle_cell0.80107521
110MP0009642_abnormal_blood_homeostasis0.79934326
111MP0003221_abnormal_cardiomyocyte_apopto0.79556530
112MP0009278_abnormal_bone_marrow0.78942949
113MP0002060_abnormal_skin_morphology0.78746456
114MP0002429_abnormal_blood_cell0.78720268
115MP0003950_abnormal_plasma_membrane0.77638633
116MP0001756_abnormal_urination0.77414367
117MP0005464_abnormal_platelet_physiology0.77318825
118MP0002136_abnormal_kidney_physiology0.75537419
119MP0003806_abnormal_nucleotide_metabolis0.75133025
120MP0003656_abnormal_erythrocyte_physiolo0.74366001
121MP0005584_abnormal_enzyme/coenzyme_acti0.74059813
122MP0002822_catalepsy0.73999648
123MP0001881_abnormal_mammary_gland0.73835905
124MP0000465_gastrointestinal_hemorrhage0.73110618
125MP0002722_abnormal_immune_system0.72038136
126MP0008872_abnormal_physiological_respon0.71788159
127MP0000689_abnormal_spleen_morphology0.71073242
128MP0005334_abnormal_fat_pad0.70539690
129MP0001545_abnormal_hematopoietic_system0.69580356
130MP0005397_hematopoietic_system_phenotyp0.69580356
131MP0001986_abnormal_taste_sensitivity0.68498997
132MP0000343_altered_response_to0.68335951
133MP0003315_abnormal_perineum_morphology0.68049261
134MP0005166_decreased_susceptibility_to0.67871196
135MP0001188_hyperpigmentation0.67393417
136MP0010307_abnormal_tumor_latency0.67288040
137MP0009333_abnormal_splenocyte_physiolog0.66888118
138MP0005375_adipose_tissue_phenotype0.66781387
139MP0005501_abnormal_skin_physiology0.64904416
140MP0005636_abnormal_mineral_homeostasis0.64715066
141MP0004957_abnormal_blastocyst_morpholog0.64068014

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.20327567
2Abnormality of glutamine family amino acid metabolism (HP:0010902)4.70159995
3Autoimmune thrombocytopenia (HP:0001973)4.69187887
4Systemic lupus erythematosus (HP:0002725)4.47911669
5Thrombocytosis (HP:0001894)4.43472815
6Acanthocytosis (HP:0001927)3.92169340
7Hydroxyprolinuria (HP:0003080)3.58963654
8Abnormality of proline metabolism (HP:0010907)3.58963654
9Malnutrition (HP:0004395)3.58530741
10Hypobetalipoproteinemia (HP:0003563)3.55003254
11Right ventricular cardiomyopathy (HP:0011663)3.51353236
12Nausea (HP:0002018)3.50677745
13Chronic otitis media (HP:0000389)3.33239628
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.28120678
15Autoimmune hemolytic anemia (HP:0001890)3.25049601
16Hyperglycinuria (HP:0003108)3.21802303
17Periodontitis (HP:0000704)3.17586880
18Confusion (HP:0001289)3.15791007
19Hemorrhage of the eye (HP:0011885)3.11015860
20Glycosuria (HP:0003076)3.10333411
21Abnormality of urine glucose concentration (HP:0011016)3.10333411
22B lymphocytopenia (HP:0010976)3.07590503
23Abnormality of B cell number (HP:0010975)3.07590503
24Abnormality of the vitamin B12 metabolism (HP:0004341)3.02393172
25Increased muscle lipid content (HP:0009058)3.00550875
26Elevated erythrocyte sedimentation rate (HP:0003565)2.99960499
27Conjugated hyperbilirubinemia (HP:0002908)2.93897224
28Ventricular fibrillation (HP:0001663)2.93202436
29Congenital sensorineural hearing impairment (HP:0008527)2.92135925
30Xanthomatosis (HP:0000991)2.88816138
31Eosinophilia (HP:0001880)2.87757256
32Hypophosphatemia (HP:0002148)2.87109219
33Pigmentary retinal degeneration (HP:0001146)2.86889266
34Cupped ribs (HP:0000887)2.85303607
35Granulocytopenia (HP:0001913)2.74750115
36Abnormality of vitamin B metabolism (HP:0004340)2.74264052
37Gastrointestinal dysmotility (HP:0002579)2.73749397
38Abdominal distention (HP:0003270)2.68761386
39Pustule (HP:0200039)2.67388936
40Ureteral stenosis (HP:0000071)2.67106961
41Abnormality of pyrimidine metabolism (HP:0004353)2.65954245
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62557529
43Dicarboxylic aciduria (HP:0003215)2.62557529
44Mesangial abnormality (HP:0001966)2.61665268
45Chronic diarrhea (HP:0002028)2.60419781
46Hepatic necrosis (HP:0002605)2.59745799
47Increased mean platelet volume (HP:0011877)2.58414553
48Encephalitis (HP:0002383)2.55067839
49Nasal polyposis (HP:0100582)2.54327332
50Agammaglobulinemia (HP:0004432)2.52582096
51Villous atrophy (HP:0011473)2.52237285
52Abnormality of small intestinal villus morphology (HP:0011472)2.52237285
53Myositis (HP:0100614)2.48812706
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.48242169
55Abnormality of fatty-acid metabolism (HP:0004359)2.47480465
56Alkalosis (HP:0001948)2.47377217
57Rectal prolapse (HP:0002035)2.46384877
58Emphysema (HP:0002097)2.45899351
59Poikilocytosis (HP:0004447)2.45075478
60Glomerulonephritis (HP:0000099)2.44203549
61Abnormality of the nasal mucosa (HP:0000433)2.43996454
62Gastrointestinal infarctions (HP:0005244)2.42405183
63Reduced antithrombin III activity (HP:0001976)2.40444149
64Nephrolithiasis (HP:0000787)2.40254495
65Hyperammonemia (HP:0001987)2.39535036
66Abnormal platelet volume (HP:0011876)2.39408290
67Abnormality of complement system (HP:0005339)2.37479899
68Hypolipoproteinemia (HP:0010981)2.36914686
69Abnormality of serine family amino acid metabolism (HP:0010894)2.36152354
70Abnormality of glycine metabolism (HP:0010895)2.36152354
71Gingivitis (HP:0000230)2.36115651
72Ureteral obstruction (HP:0006000)2.35748887
73Hypoglycemic coma (HP:0001325)2.33052199
74Recurrent fungal infections (HP:0002841)2.30880261
75Abnormality of chloride homeostasis (HP:0011422)2.30879746
76Recurrent bronchitis (HP:0002837)2.30672638
77Eczematoid dermatitis (HP:0000976)2.30526525
78Pancreatitis (HP:0001733)2.30479183
79Vasculitis (HP:0002633)2.30147714
80Widely patent fontanelles and sutures (HP:0004492)2.29973096
81Abnormality of macrophages (HP:0004311)2.29572459
82Complement deficiency (HP:0004431)2.28928189
83Gastrointestinal inflammation (HP:0004386)2.28520205
84Abnormality of purine metabolism (HP:0004352)2.28313682
85Dehydration (HP:0001944)2.26562618
86Increased IgE level (HP:0003212)2.26375754
87Enlarged epiphyses (HP:0010580)2.25478120
88Meningitis (HP:0001287)2.25309327
89Increased purine levels (HP:0004368)2.24867579
90Hyperuricemia (HP:0002149)2.24867579
91Inflammation of the large intestine (HP:0002037)2.23266102
92Orchitis (HP:0100796)2.22808287
93Cheilitis (HP:0100825)2.22579286
94Poikiloderma (HP:0001029)2.21660129
95Fat malabsorption (HP:0002630)2.21005174
96Colitis (HP:0002583)2.19209814
97Abnormal urine phosphate concentration (HP:0012599)2.18185586
98Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.17939776
99Proximal tubulopathy (HP:0000114)2.17475551
100Gastrointestinal stroma tumor (HP:0100723)2.16825255
101Decreased circulating renin level (HP:0003351)2.15795927
102Cerebral palsy (HP:0100021)2.15480209
103Increased intramyocellular lipid droplets (HP:0012240)2.13902274
104Hyperactive renin-angiotensin system (HP:0000841)2.13613474
105Skin rash (HP:0000988)2.13485601
106Steatorrhea (HP:0002570)2.12812665
107Recurrent bacterial skin infections (HP:0005406)2.11954743
108Combined immunodeficiency (HP:0005387)2.11803743
109Generalized aminoaciduria (HP:0002909)2.11709538
110Abnormality of eosinophils (HP:0001879)2.10772786
111Abnormal enzyme/coenzyme activity (HP:0012379)2.08891093
112Metabolic acidosis (HP:0001942)2.07259440
113Lipid accumulation in hepatocytes (HP:0006561)2.06701752
114Nonimmune hydrops fetalis (HP:0001790)2.05281174
115Cellulitis (HP:0100658)2.05068107
116Reticulocytopenia (HP:0001896)2.03538816
117Recurrent abscess formation (HP:0002722)2.03372931
118Hepatocellular necrosis (HP:0001404)2.01534185
119Abnormality of alkaline phosphatase activity (HP:0004379)2.01468559
120Delayed epiphyseal ossification (HP:0002663)2.01315461
121Ketoacidosis (HP:0001993)2.01239605
122Bone cyst (HP:0012062)2.00574593
123Panhypogammaglobulinemia (HP:0003139)1.99322204
124Severe combined immunodeficiency (HP:0004430)1.99032109
125Rhabdomyolysis (HP:0003201)1.98808637
126Abnormality of vitamin metabolism (HP:0100508)1.98317848
127Recurrent gram-negative bacterial infections (HP:0005420)1.97550621
128Metabolic alkalosis (HP:0200114)1.97206630
129Abnormality of T cell physiology (HP:0011840)1.96876752
130Abnormal biliary tract morphology (HP:0012440)1.96132862
131Hypertriglyceridemia (HP:0002155)1.95828244
132Hyperparathyroidism (HP:0000843)1.95791497
133Mediastinal lymphadenopathy (HP:0100721)1.94052559
134Wide cranial sutures (HP:0010537)1.93146737
135Abnormality of the gastric mucosa (HP:0004295)1.93132537
136Chronic obstructive pulmonary disease (HP:0006510)1.93098037
137Obstructive lung disease (HP:0006536)1.93098037
138Hyperphosphaturia (HP:0003109)1.92055023
139Insulin resistance (HP:0000855)1.91205875
140Hypercholesterolemia (HP:0003124)1.88150002
141Nephritis (HP:0000123)1.87760349
142Abnormality of the costochondral junction (HP:0000919)1.85923946
143Abnormality of nucleobase metabolism (HP:0010932)1.84999673
144Late onset (HP:0003584)1.84874859
145Multiple enchondromatosis (HP:0005701)1.84858653
146Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.83538066
147Facial shape deformation (HP:0011334)1.83201345
148Potter facies (HP:0002009)1.83201345
149Petechiae (HP:0000967)1.82720992
150Woolly hair (HP:0002224)1.80472045
151Type I transferrin isoform profile (HP:0003642)1.80022776
152Thin bony cortex (HP:0002753)1.79641692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK25.56095863
2FRK4.74018958
3MST1R3.72363366
4PRKG23.03259697
5NME13.00640909
6ERN13.00465846
7MST42.84511006
8MAP3K132.76961549
9RIPK12.36458448
10GRK62.23781284
11TAOK32.20345336
12TESK12.14241394
13MAP2K62.06003679
14MYLK2.04965520
15PRPF4B2.01932825
16IRAK41.94767595
17MAP3K121.93368160
18MAP2K21.86780251
19FGFR41.74392153
20TTK1.67857926
21TESK21.59820143
22NUAK11.57529698
23ZAP701.57040958
24MAP2K31.52230518
25EPHB21.51075921
26MAP3K111.46763432
27PKN21.41994403
28PTK61.41316491
29IRAK31.40203261
30AKT31.39720900
31TXK1.37749921
32PIM21.32777004
33PAK41.29240601
34SIK11.26106674
35TEC1.25093386
36BLK1.25063781
37KIT1.22549494
38MAP3K61.21746608
39IKBKE1.20110686
40JAK31.18618491
41MAP3K81.17294558
42TNK21.16407568
43TIE11.15993402
44MAP3K101.14802858
45SYK1.14788199
46STK101.13596227
47SIK21.10972860
48IKBKB1.03047769
49EPHA31.02221451
50TAOK11.02129556
51FES1.02083095
52CSF1R0.99379897
53DYRK1B0.98549951
54SMG10.95331899
55KSR20.93569853
56ITK0.92056588
57EPHB10.89840385
58PRKD20.89735364
59CDC42BPA0.89608700
60HCK0.87260324
61BMPR20.86165619
62IRAK10.86074771
63EIF2AK10.83625988
64STK160.82173822
65MAPK110.81388240
66EEF2K0.81248054
67MAP3K20.80936056
68LYN0.80599269
69PRKAA20.80223767
70LCK0.80099756
71NEK10.80066633
72TRIB30.79616054
73MAP3K30.76541006
74NEK20.76406137
75KDR0.76126643
76PDK10.73926590
77MAP4K10.73487936
78CDK90.73006634
79AURKB0.72482662
80PDK30.72068268
81PDK40.72068268
82BCKDK0.71479092
83SIK30.71423751
84PDK20.69169671
85JAK10.68496912
86FGFR30.67845906
87JAK20.67625968
88MET0.66873480
89HIPK20.64918993
90RPS6KL10.64183692
91RPS6KC10.64183692
92MAP2K10.62858853
93TRPM70.62397503
94MAPK40.60983712
95EPHA20.60548496
96BMX0.58864173
97RPS6KA60.58309562
98PIM10.57227343
99LRRK20.57140068
100ABL20.56633623
101RIPK40.56076063
102LIMK10.55989093
103MAP3K140.55829405
104SCYL20.55339133
105TLK10.54475309
106PAK10.54164797
107CDK190.54082573
108PIK3CA0.53991877
109PRKCQ0.52369424
110DAPK20.51951964
111MAP3K10.51585965
112TAOK20.50445202
113TBK10.49961738
114ACVR1B0.48085426
115GRK10.47831574
116MATK0.46654012
117OXSR10.45248969
118PRKAA10.44423630
119NLK0.44166785
120RPS6KA20.43293735
121PRKCZ0.42892583
122FLT30.42274490
123DDR20.41680961
124CHUK0.41589703
125FYN0.41533061
126CDK60.40456804
127CDK70.40394451
128BUB10.39426639
129PRKCI0.39054426
130MAP3K70.38588529
131STK390.38296398
132WNK40.37593053
133RET0.37264871
134CDK40.37122099
135MAPKAPK30.36836046
136MAPK70.36702255
137PRKACG0.34907558
138MARK20.34830974
139DMPK0.34704816
140PRKCD0.34627122
141BRSK20.34228927
142TGFBR10.34206794
143TYK20.33689476
144ERBB20.33098183
145RPS6KB10.33061631
146PDPK10.32969161
147MAPK30.32727091
148MAPKAPK20.31885221
149IRAK20.31773771
150VRK10.30858755
151BTK0.30538930
152PBK0.29962199
153CSK0.29341961

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.05045340
2Fat digestion and absorption_Homo sapiens_hsa049754.88469206
3Renin-angiotensin system_Homo sapiens_hsa046143.98567292
4Vitamin digestion and absorption_Homo sapiens_hsa049772.99645845
5Galactose metabolism_Homo sapiens_hsa000522.95528187
6Mineral absorption_Homo sapiens_hsa049782.74749860
7Starch and sucrose metabolism_Homo sapiens_hsa005002.61881419
8Sulfur metabolism_Homo sapiens_hsa009202.39861176
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.32144078
10Fructose and mannose metabolism_Homo sapiens_hsa000512.23495294
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.11580553
12Glutathione metabolism_Homo sapiens_hsa004802.04175271
13Caffeine metabolism_Homo sapiens_hsa002322.03072896
14Pentose phosphate pathway_Homo sapiens_hsa000302.02045168
15Folate biosynthesis_Homo sapiens_hsa007902.01691942
16Carbohydrate digestion and absorption_Homo sapiens_hsa049732.01444030
17Asthma_Homo sapiens_hsa053101.99564548
18Allograft rejection_Homo sapiens_hsa053301.93119014
19Histidine metabolism_Homo sapiens_hsa003401.93045202
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84270141
21Graft-versus-host disease_Homo sapiens_hsa053321.83736002
22Protein digestion and absorption_Homo sapiens_hsa049741.82772168
23Staphylococcus aureus infection_Homo sapiens_hsa051501.77671179
24Autoimmune thyroid disease_Homo sapiens_hsa053201.75752981
25Fatty acid degradation_Homo sapiens_hsa000711.68508992
26Glycerolipid metabolism_Homo sapiens_hsa005611.64206653
27PPAR signaling pathway_Homo sapiens_hsa033201.63538624
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57986143
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.54496663
30Carbon metabolism_Homo sapiens_hsa012001.42775014
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.41196354
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.38617577
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37690057
34Type I diabetes mellitus_Homo sapiens_hsa049401.34951001
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25537060
36Bile secretion_Homo sapiens_hsa049761.24828358
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.21363344
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20598926
39Tryptophan metabolism_Homo sapiens_hsa003801.18136100
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16825330
41Antigen processing and presentation_Homo sapiens_hsa046121.16203533
42Pyruvate metabolism_Homo sapiens_hsa006201.11267029
43beta-Alanine metabolism_Homo sapiens_hsa004101.10969691
44Primary immunodeficiency_Homo sapiens_hsa053401.06781041
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04863010
46Arginine and proline metabolism_Homo sapiens_hsa003301.02022813
47Sphingolipid metabolism_Homo sapiens_hsa006001.01370834
48Arachidonic acid metabolism_Homo sapiens_hsa005900.99350841
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98421937
50Propanoate metabolism_Homo sapiens_hsa006400.97920865
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97099002
52Phenylalanine metabolism_Homo sapiens_hsa003600.91741269
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.91583931
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90461985
55Ether lipid metabolism_Homo sapiens_hsa005650.90241974
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85884723
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85461285
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84624852
59Fatty acid metabolism_Homo sapiens_hsa012120.81623535
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80088601
61N-Glycan biosynthesis_Homo sapiens_hsa005100.79685373
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76606579
63B cell receptor signaling pathway_Homo sapiens_hsa046620.75772940
64Thyroid hormone synthesis_Homo sapiens_hsa049180.72395878
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.72325568
66Other glycan degradation_Homo sapiens_hsa005110.71168064
67ABC transporters_Homo sapiens_hsa020100.69569633
68Chemical carcinogenesis_Homo sapiens_hsa052040.69283484
69Parkinsons disease_Homo sapiens_hsa050120.68166427
70Hematopoietic cell lineage_Homo sapiens_hsa046400.67906520
71Peroxisome_Homo sapiens_hsa041460.67669174
72Biosynthesis of amino acids_Homo sapiens_hsa012300.67172275
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66301804
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65635484
75Toxoplasmosis_Homo sapiens_hsa051450.65501041
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.64892325
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.64762463
78Osteoclast differentiation_Homo sapiens_hsa043800.61577605
79Oxidative phosphorylation_Homo sapiens_hsa001900.61369732
80Viral myocarditis_Homo sapiens_hsa054160.59494402
81Alzheimers disease_Homo sapiens_hsa050100.56626885
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56468578
83Tuberculosis_Homo sapiens_hsa051520.56354675
84Leishmaniasis_Homo sapiens_hsa051400.55704148
85Complement and coagulation cascades_Homo sapiens_hsa046100.54638263
86Acute myeloid leukemia_Homo sapiens_hsa052210.54178910
87* Leukocyte transendothelial migration_Homo sapiens_hsa046700.53503708
88Nitrogen metabolism_Homo sapiens_hsa009100.53246242
89Ribosome_Homo sapiens_hsa030100.52864777
90Arginine biosynthesis_Homo sapiens_hsa002200.52211500
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.51992714
92Metabolic pathways_Homo sapiens_hsa011000.51218441
93Fatty acid biosynthesis_Homo sapiens_hsa000610.49784572
94Herpes simplex infection_Homo sapiens_hsa051680.49321093
95DNA replication_Homo sapiens_hsa030300.48924425
96Thyroid cancer_Homo sapiens_hsa052160.48171027
97Sulfur relay system_Homo sapiens_hsa041220.45582472
98Retinol metabolism_Homo sapiens_hsa008300.43016408
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.42514908
100Tyrosine metabolism_Homo sapiens_hsa003500.42172036
101Linoleic acid metabolism_Homo sapiens_hsa005910.39865443
102Legionellosis_Homo sapiens_hsa051340.39748687
103TNF signaling pathway_Homo sapiens_hsa046680.39575636
104African trypanosomiasis_Homo sapiens_hsa051430.39232691
105Chemokine signaling pathway_Homo sapiens_hsa040620.38552981
106Lysine degradation_Homo sapiens_hsa003100.38000916
107Bladder cancer_Homo sapiens_hsa052190.37468402
108Huntingtons disease_Homo sapiens_hsa050160.37171944
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37163907
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36224709
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35328952
112T cell receptor signaling pathway_Homo sapiens_hsa046600.35111460
113Salmonella infection_Homo sapiens_hsa051320.32342746
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32109213
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29940094
116Butanoate metabolism_Homo sapiens_hsa006500.28558211
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27636844
118Pancreatic secretion_Homo sapiens_hsa049720.26476015
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.26266131
120Pertussis_Homo sapiens_hsa051330.25188693
121Homologous recombination_Homo sapiens_hsa034400.21398650
122Purine metabolism_Homo sapiens_hsa002300.20534352
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19992312
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.18621500
125* Hepatitis C_Homo sapiens_hsa051600.17555535
126Rheumatoid arthritis_Homo sapiens_hsa053230.16367544
127Influenza A_Homo sapiens_hsa051640.14790311
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.14623315
129Selenocompound metabolism_Homo sapiens_hsa004500.14615889
130Protein export_Homo sapiens_hsa030600.14289211
131Insulin resistance_Homo sapiens_hsa049310.13632326
132Fatty acid elongation_Homo sapiens_hsa000620.12495522
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.11534968
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10817242
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.09633020
136* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.09477077

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