CLDN16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)9.73782118
2lysine metabolic process (GO:0006553)9.13680800
3lysine catabolic process (GO:0006554)9.13680800
4aminoglycoside antibiotic metabolic process (GO:0030647)8.50607100
5drug transport (GO:0015893)8.49201138
6organic cation transport (GO:0015695)8.44790266
7regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033398.00638808
8phosphate ion transport (GO:0006817)7.61828491
9response to mercury ion (GO:0046689)7.53400321
10nephron tubule formation (GO:0072079)7.19445746
11cysteine metabolic process (GO:0006534)7.11437851
12* excretion (GO:0007588)6.70529042
13phosphate ion transmembrane transport (GO:0035435)6.58149353
14metanephric tubule development (GO:0072170)6.55706390
15metanephric nephron tubule development (GO:0072234)6.55706390
16iron coordination entity transport (GO:1901678)6.29481130
17quaternary ammonium group transport (GO:0015697)6.22635524
18renal absorption (GO:0070293)6.19167132
19nonribosomal peptide biosynthetic process (GO:0019184)6.09812322
20glyoxylate metabolic process (GO:0046487)6.05903907
21metanephric nephron epithelium development (GO:0072243)6.01426406
22aspartate family amino acid catabolic process (GO:0009068)6.00356663
23negative regulation of metanephros development (GO:0072217)5.92420187
24axonemal dynein complex assembly (GO:0070286)5.69767454
25polyol transport (GO:0015791)5.60267437
26metanephric epithelium development (GO:0072207)5.58488015
27glutathione biosynthetic process (GO:0006750)5.56987986
28indole-containing compound catabolic process (GO:0042436)5.51422416
29indolalkylamine catabolic process (GO:0046218)5.51422416
30tryptophan catabolic process (GO:0006569)5.51422416
31pattern specification involved in kidney development (GO:0061004)5.47948679
32negative regulation of mesenchymal cell apoptotic process (GO:2001054)5.40645094
332-oxoglutarate metabolic process (GO:0006103)5.37553042
34short-chain fatty acid metabolic process (GO:0046459)5.36547311
35tricarboxylic acid metabolic process (GO:0072350)5.29487936
36aromatic amino acid family catabolic process (GO:0009074)5.22638603
37mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.21794903
38vitamin D metabolic process (GO:0042359)5.21027635
39tryptophan metabolic process (GO:0006568)5.19700373
40branched-chain amino acid metabolic process (GO:0009081)5.16333982
41regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)5.14421512
42regulation of apoptotic process involved in morphogenesis (GO:1902337)5.12933686
43drug catabolic process (GO:0042737)5.07999334
44urogenital system development (GO:0001655)5.05809137
45valine metabolic process (GO:0006573)5.05753843
46cilium or flagellum-dependent cell motility (GO:0001539)5.04028191
47toxin transport (GO:1901998)4.95819381
48modified amino acid transport (GO:0072337)4.92269247
49kynurenine metabolic process (GO:0070189)4.86744143
50homocysteine metabolic process (GO:0050667)4.85044414
51nephron tubule development (GO:0072080)4.82391772
52cilium movement (GO:0003341)4.80731292
53response to phenylpropanoid (GO:0080184)4.79114031
54L-phenylalanine metabolic process (GO:0006558)4.70605035
55erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.70605035
56amino-acid betaine transport (GO:0015838)4.68074954
57carnitine transport (GO:0015879)4.68074954
58positive regulation of gastrulation (GO:2000543)4.66613942
59exogenous drug catabolic process (GO:0042738)4.65939331
60cellular ketone body metabolic process (GO:0046950)4.65286454
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.59724606
62L-phenylalanine catabolic process (GO:0006559)4.59724606
63nitric oxide mediated signal transduction (GO:0007263)4.56863970
64negative regulation of T cell differentiation in thymus (GO:0033085)4.54366989
65mesonephros development (GO:0001823)4.52759391
66acetyl-CoA metabolic process (GO:0006084)4.50045082
67glutamate metabolic process (GO:0006536)4.45664732
68peptide biosynthetic process (GO:0043043)4.42484179
69cellular modified amino acid catabolic process (GO:0042219)4.41970747
70epithelial cilium movement (GO:0003351)4.39694411
71axoneme assembly (GO:0035082)4.39600941
72motile cilium assembly (GO:0044458)4.37875377
73fructose metabolic process (GO:0006000)4.36971062
74phosphate ion homeostasis (GO:0055062)4.35254774
75trivalent inorganic anion homeostasis (GO:0072506)4.35254774
76regulation of mesenchymal cell apoptotic process (GO:2001053)4.34906917
77branched-chain amino acid catabolic process (GO:0009083)4.30637245
78serine family amino acid metabolic process (GO:0009069)4.28907212
79parturition (GO:0007567)4.27518586
80amino-acid betaine metabolic process (GO:0006577)4.27458112
81renal tubule development (GO:0061326)4.25229189
82serine family amino acid catabolic process (GO:0009071)4.24971495
83fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.23768898
84fatty acid beta-oxidation (GO:0006635)4.21223328
85* calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.21188517
86embryonic epithelial tube formation (GO:0001838)4.16566233
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.16391607
88proline metabolic process (GO:0006560)4.16253904
89positive regulation of vesicle fusion (GO:0031340)4.09918781
90lens fiber cell development (GO:0070307)4.07038712
91carnitine metabolic process (GO:0009437)4.01959438
92fatty acid oxidation (GO:0019395)4.01468637
93ketone body metabolic process (GO:1902224)3.99994961
94ovulation from ovarian follicle (GO:0001542)3.99105501
95nephron epithelium development (GO:0072009)3.97372809
96negative regulation of kidney development (GO:0090185)3.97206893
97epithelial tube formation (GO:0072175)3.93737849
98lipid oxidation (GO:0034440)3.93656410
99cornea development in camera-type eye (GO:0061303)3.87388828
100vitamin transport (GO:0051180)3.86916254
101indolalkylamine metabolic process (GO:0006586)3.86578281
102aromatic amino acid family metabolic process (GO:0009072)3.85222660
103platelet dense granule organization (GO:0060155)3.80138357
104indole-containing compound metabolic process (GO:0042430)3.79068059
105glutathione derivative biosynthetic process (GO:1901687)3.77613244
106glutathione derivative metabolic process (GO:1901685)3.77613244
107glycoside metabolic process (GO:0016137)3.74254934
108regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.71150245
109positive regulation of metanephros development (GO:0072216)3.69218275
110cGMP-mediated signaling (GO:0019934)3.68370178
111mitochondrial calcium ion transport (GO:0006851)3.67636185
112cell-cell junction maintenance (GO:0045217)3.64529760
113peptide catabolic process (GO:0043171)3.63468636
114cellular amino acid catabolic process (GO:0009063)3.61904473
115transepithelial transport (GO:0070633)3.60847183
116amine catabolic process (GO:0009310)3.59981138
117cellular biogenic amine catabolic process (GO:0042402)3.59981138
118arginine catabolic process (GO:0006527)3.56669540
119glutathione metabolic process (GO:0006749)3.56348811
120NADH metabolic process (GO:0006734)3.55931113
121surfactant homeostasis (GO:0043129)3.53609155
122embryonic heart tube development (GO:0035050)3.53533339
123alpha-amino acid catabolic process (GO:1901606)3.52113206
124response to growth hormone (GO:0060416)3.51633773
125benzene-containing compound metabolic process (GO:0042537)3.50166617
126behavioral response to nicotine (GO:0035095)3.49160348
127interferon-gamma secretion (GO:0072643)3.48776774
128fatty acid catabolic process (GO:0009062)3.47627071
129regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.42327574
130L-ascorbic acid metabolic process (GO:0019852)3.42202623
131regulation of stem cell maintenance (GO:2000036)3.41811493
132biotin metabolic process (GO:0006768)3.39620261
133collecting duct development (GO:0072044)3.38921322
134endoderm formation (GO:0001706)3.37774772
135serine family amino acid biosynthetic process (GO:0009070)3.36566472
136sulfur amino acid catabolic process (GO:0000098)3.35272143
137cell volume homeostasis (GO:0006884)3.34721706
138oligosaccharide catabolic process (GO:0009313)3.33905763
139sodium ion transport (GO:0006814)3.32916507
140dicarboxylic acid metabolic process (GO:0043648)3.31515993
141positive regulation of hormone metabolic process (GO:0032352)3.31156756
142nephron tubule morphogenesis (GO:0072078)3.30720008
143nephron epithelium morphogenesis (GO:0072088)3.30720008
144sulfur compound transport (GO:0072348)3.30578218
145organic acid catabolic process (GO:0016054)3.28877480
146carboxylic acid catabolic process (GO:0046395)3.28877480
147left/right axis specification (GO:0070986)3.27995375
148neural tube formation (GO:0001841)3.27236693
149one-carbon compound transport (GO:0019755)3.24274769
150mesenchymal to epithelial transition (GO:0060231)3.23018469
151ear development (GO:0043583)3.20823510
152cell junction maintenance (GO:0034331)3.18349570
153protein-cofactor linkage (GO:0018065)3.15872939
154regulation of regulatory T cell differentiation (GO:0045589)3.14229957
155specification of organ identity (GO:0010092)3.12900665
156regulation of metanephros development (GO:0072215)3.11008022
157regulation of gastrulation (GO:0010470)3.08738408
158arginine metabolic process (GO:0006525)3.00501329
159cellular response to gonadotropin stimulus (GO:0071371)3.00113706
160regulation of mesoderm development (GO:2000380)2.95788621
161positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.84530810
162sodium-independent organic anion transport (GO:0043252)2.84409887
163L-fucose catabolic process (GO:0042355)2.82706028
164fucose catabolic process (GO:0019317)2.82706028
165L-fucose metabolic process (GO:0042354)2.82706028
166male meiosis I (GO:0007141)2.81570282
167regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.78015825
168regulation of hippo signaling (GO:0035330)2.77553858
169regulation of transcription involved in cell fate commitment (GO:0060850)2.74781317
170thyroid gland development (GO:0030878)2.74132429
171cytokine production involved in immune response (GO:0002367)2.72887904
172regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.72361443
173tyrosine phosphorylation of STAT protein (GO:0007260)2.66124035
174positive regulation of fatty acid beta-oxidation (GO:0032000)2.63611472
175organelle disassembly (GO:1903008)2.62967826
176left/right pattern formation (GO:0060972)2.62687224
177preassembly of GPI anchor in ER membrane (GO:0016254)2.59005063
178cilium organization (GO:0044782)2.57586601
179positive regulation of mesonephros development (GO:0061213)2.53995092
180positive regulation of tolerance induction (GO:0002645)2.53164260
181regulation of mesonephros development (GO:0061217)2.53147620
182cardiovascular system development (GO:0072358)2.53101875
183inositol phosphate-mediated signaling (GO:0048016)2.50267258
184positive regulation of sodium ion transmembrane transport (GO:1902307)2.49060636
185positive regulation of cellular amine metabolic process (GO:0033240)2.45585847
186urate metabolic process (GO:0046415)10.1096448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.28371722
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.47963543
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.96046638
4VDR_22108803_ChIP-Seq_LS180_Human3.73407513
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.51400637
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.36782497
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.35908550
8ZNF274_21170338_ChIP-Seq_K562_Hela3.28979569
9ESR1_15608294_ChIP-ChIP_MCF-7_Human2.98421594
10AR_21909140_ChIP-Seq_LNCAP_Human2.84888268
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.71206721
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.69749001
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.69719145
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.53779369
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.45225846
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.44509884
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.39279477
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23068748
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.19969879
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.17283277
21SRY_22984422_ChIP-ChIP_TESTIS_Rat2.15519729
22CLOCK_20551151_ChIP-Seq_293T_Human1.94201695
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82760326
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82687549
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82665236
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.76761063
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.74905077
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72345442
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67565177
30ERA_21632823_ChIP-Seq_H3396_Human1.67242341
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64659793
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.64304889
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.63058500
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59619887
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.56319388
36GATA4_25053715_ChIP-Seq_YYC3_Human1.53602745
37GBX2_23144817_ChIP-Seq_PC3_Human1.51573882
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.48798709
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47263589
40TP53_16413492_ChIP-PET_HCT116_Human1.45488001
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43968760
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41386546
43TDRD3_21172665_ChIP-Seq_MCF-7_Human1.40431460
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.39238486
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37718645
46TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.37256912
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.35421293
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35421293
49DROSHA_22980978_ChIP-Seq_HELA_Human1.35086419
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33047017
51IGF1R_20145208_ChIP-Seq_DFB_Human1.32993193
52BCAT_22108803_ChIP-Seq_LS180_Human1.32989267
53STAT1_20625510_ChIP-Seq_HELA_Human1.32260185
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32252683
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.30980341
56* HNF4A_19822575_ChIP-Seq_HepG2_Human1.29929457
57RXR_22108803_ChIP-Seq_LS180_Human1.29814010
58P53_21459846_ChIP-Seq_SAOS-2_Human1.29066373
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28658798
60HOXB7_26014856_ChIP-Seq_BT474_Human1.27445565
61EZH2_22144423_ChIP-Seq_EOC_Human1.26868001
62YY1_22570637_ChIP-Seq_MALME-3M_Human1.24363404
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24005600
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23706807
65P300_19829295_ChIP-Seq_ESCs_Human1.23366372
66SMAD3_21741376_ChIP-Seq_HESCs_Human1.20484493
67FOXA2_19822575_ChIP-Seq_HepG2_Human1.20078071
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19024640
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17916076
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16590769
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15793295
72ER_23166858_ChIP-Seq_MCF-7_Human1.14489487
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14031911
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13759393
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12743575
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.12378045
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11805836
78RACK7_27058665_Chip-Seq_MCF-7_Human1.11552873
79EGR1_19032775_ChIP-ChIP_M12_Human1.10274089
80LXR_22292898_ChIP-Seq_THP-1_Human1.09021002
81SOX2_20726797_ChIP-Seq_SW620_Human1.06935726
82GATA3_21878914_ChIP-Seq_MCF-7_Human1.04649126
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04185847
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03743022
85EP300_21415370_ChIP-Seq_HL-1_Mouse1.02338878
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01857526
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01200154
88EZH2_27304074_Chip-Seq_ESCs_Mouse1.01067296
89LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00452460
90GATA6_25053715_ChIP-Seq_YYC3_Human0.99838716
91SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99799236
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99623173
93SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99168791
94NCOR_22424771_ChIP-Seq_293T_Human0.98615002
95IRF1_19129219_ChIP-ChIP_H3396_Human0.98488823
96NANOG_20526341_ChIP-Seq_ESCs_Human0.98100379
97OCT1_27270436_Chip-Seq_PROSTATE_Human0.97820369
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.97590501
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96818589
100* MYC_19829295_ChIP-Seq_ESCs_Human0.96684594
101SMAD4_21741376_ChIP-Seq_EPCs_Human0.95700484
102PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95616208
103TBX20_22080862_ChIP-Seq_HEART_Mouse0.95571240
104TBX20_22328084_ChIP-Seq_HEART_Mouse0.95571240
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95011080
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94901167
107ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94299503
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94283459
109SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94084561
110POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94073166
111* TAF2_19829295_ChIP-Seq_ESCs_Human0.92190520
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92189184
113AR_25329375_ChIP-Seq_VCAP_Human0.90935753
114TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90187545
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89256157
116FOXH1_21741376_ChIP-Seq_ESCs_Human0.87803807
117SMAD3_21741376_ChIP-Seq_EPCs_Human0.87457745
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86985001
119* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.86449913
120* KLF5_25053715_ChIP-Seq_YYC3_Human0.86154934
121CDX2_22108803_ChIP-Seq_LS180_Human0.86067808
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85695465
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85695465
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85299258
125VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83699122
126NANOG_18692474_ChIP-Seq_MEFs_Mouse0.82432169
127HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.81894843
128OCT4_20526341_ChIP-Seq_ESCs_Human0.81471052
129EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81048673
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80944299
131RUNX1_27514584_Chip-Seq_MCF-7_Human0.80729770
132* SMRT_27268052_Chip-Seq_Bcells_Human0.80574425
133RNF2_27304074_Chip-Seq_ESCs_Mouse0.80533902
134* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80347784
135TCF4_23295773_ChIP-Seq_U87_Human0.79935356
136SUZ12_27294783_Chip-Seq_ESCs_Mouse0.79904954
137* TP63_23658742_ChIP-Seq_EP156T_Human0.79714134
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79637065
139SOX11_22085726_ChIP-Seq_ESNs_Mouse0.79555046
140CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.79508737
141EOMES_21245162_ChIP-Seq_HESCs_Human0.79483433
142SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79177182
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79131340
144EZH2_18974828_ChIP-Seq_MESCs_Mouse0.79041224
145RNF2_18974828_ChIP-Seq_MESCs_Mouse0.79041224
146TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78868950
147SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78542492
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.77990654
149TCF4_22108803_ChIP-Seq_LS180_Human0.77528364
150NANOG_19829295_ChIP-Seq_ESCs_Human0.77233520
151SOX2_19829295_ChIP-Seq_ESCs_Human0.77233520
152SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.76817173
153GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75883624
154RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75458418
155MYC_19915707_ChIP-ChIP_AK7_Human0.75368216
156VDR_24787735_ChIP-Seq_THP-1_Human0.75270910
157SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.74637538
158GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72099512
159ARNT_22903824_ChIP-Seq_MCF-7_Human0.71530460
160ESET_19884257_ChIP-Seq_ESCs_Mouse0.71333093
161ESR1_20079471_ChIP-ChIP_T-47D_Human0.70900972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.95880637
2MP0004043_abnormal_pH_regulation7.16813187
3MP0003195_calcinosis5.12500598
4MP0005332_abnormal_amino_acid5.07240439
5MP0005645_abnormal_hypothalamus_physiol4.42675675
6MP0002139_abnormal_hepatobiliary_system4.08572818
7* MP0004019_abnormal_vitamin_homeostasis4.02874636
8* MP0009643_abnormal_urine_homeostasis3.94923563
9MP0001756_abnormal_urination3.83479265
10* MP0001765_abnormal_ion_homeostasis3.76037361
11MP0002138_abnormal_hepatobiliary_system3.64381953
12MP0002277_abnormal_respiratory_mucosa3.48478598
13MP0006292_abnormal_olfactory_placode3.21910663
14* MP0005636_abnormal_mineral_homeostasis3.02113947
15* MP0002136_abnormal_kidney_physiology2.94178765
16MP0005377_hearing/vestibular/ear_phenot2.92645523
17MP0003878_abnormal_ear_physiology2.92645523
18MP0008875_abnormal_xenobiotic_pharmacok2.75004265
19MP0001502_abnormal_circadian_rhythm2.73139554
20MP0002160_abnormal_reproductive_system2.58557833
21MP0005646_abnormal_pituitary_gland2.47367901
22MP0005083_abnormal_biliary_tract2.42707607
23MP0003938_abnormal_ear_development2.41053428
24MP0003183_abnormal_peptide_metabolism2.31257325
25MP0001958_emphysema2.28052376
26MP0005365_abnormal_bile_salt2.20081782
27MP0002909_abnormal_adrenal_gland2.17992374
28MP0003252_abnormal_bile_duct2.17931566
29MP0008961_abnormal_basal_metabolism2.09473276
30MP0000049_abnormal_middle_ear2.06253669
31MP0001501_abnormal_sleep_pattern2.04147475
32MP0004885_abnormal_endolymph2.03917204
33MP0005503_abnormal_tendon_morphology2.02123160
34MP0000538_abnormal_urinary_bladder1.96392014
35MP0004133_heterotaxia1.93441685
36MP0005085_abnormal_gallbladder_physiolo1.92973140
37MP0005389_reproductive_system_phenotype1.91523544
38MP0000013_abnormal_adipose_tissue1.87555268
39MP0008872_abnormal_physiological_respon1.84216200
40MP0005451_abnormal_body_composition1.78898305
41MP0005058_abnormal_lysosome_morphology1.74434772
42MP0000631_abnormal_neuroendocrine_gland1.73934973
43MP0000372_irregular_coat_pigmentation1.71704862
44MP0004858_abnormal_nervous_system1.66707463
45MP0002102_abnormal_ear_morphology1.62653966
46MP0000566_synostosis1.55492454
47MP0001881_abnormal_mammary_gland1.54589103
48MP0000681_abnormal_thyroid_gland1.54490343
49MP0002876_abnormal_thyroid_physiology1.54322295
50MP0005584_abnormal_enzyme/coenzyme_acti1.51565580
51MP0003186_abnormal_redox_activity1.51007674
52MP0002254_reproductive_system_inflammat1.45937308
53MP0003045_fibrosis1.35840567
54MP0000230_abnormal_systemic_arterial1.32341148
55MP0003936_abnormal_reproductive_system1.31323909
56MP0002177_abnormal_outer_ear1.30041409
57MP0002168_other_aberrant_phenotype1.29508259
58MP0001919_abnormal_reproductive_system1.22981605
59MP0003300_gastrointestinal_ulcer1.22630344
60MP0009046_muscle_twitch1.21729435
61MP0010030_abnormal_orbit_morphology1.20937001
62MP0005084_abnormal_gallbladder_morpholo1.20288521
63MP0005319_abnormal_enzyme/_coenzyme1.20185158
64MP0003191_abnormal_cellular_cholesterol1.16296928
65MP0002135_abnormal_kidney_morphology1.16175948
66MP0005535_abnormal_body_temperature1.15462603
67MP0005551_abnormal_eye_electrophysiolog1.15418202
68MP0003283_abnormal_digestive_organ1.11361195
69MP0006036_abnormal_mitochondrial_physio1.10821796
70MP0000383_abnormal_hair_follicle1.09890303
71MP0003806_abnormal_nucleotide_metabolis1.08005272
72MP0003646_muscle_fatigue1.07704113
73MP0002928_abnormal_bile_duct1.04577438
74MP0002127_abnormal_cardiovascular_syste1.01915134
75MP0001666_abnormal_nutrient_absorption1.00247935
76MP0002837_dystrophic_cardiac_calcinosis0.98160332
77MP0002272_abnormal_nervous_system0.97882022
78MP0004147_increased_porphyrin_level0.97293383
79MP0003136_yellow_coat_color0.97172938
80MP0009780_abnormal_chondrocyte_physiolo0.96338298
81MP0002557_abnormal_social/conspecific_i0.95742184
82MP0000685_abnormal_immune_system0.93534992
83MP0005670_abnormal_white_adipose0.93529942
84MP0001764_abnormal_homeostasis0.92126824
85MP0010234_abnormal_vibrissa_follicle0.90996726
86MP0002733_abnormal_thermal_nociception0.89791322
87MP0002184_abnormal_innervation0.89713545
88MP0003315_abnormal_perineum_morphology0.86778363
89MP0008775_abnormal_heart_ventricle0.85762362
90MP0009745_abnormal_behavioral_response0.84806994
91MP0002638_abnormal_pupillary_reflex0.84647785
92MP0008995_early_reproductive_senescence0.83731046
93MP0001944_abnormal_pancreas_morphology0.82735558
94MP0005395_other_phenotype0.82464645
95MP0001661_extended_life_span0.82375028
96MP0005253_abnormal_eye_physiology0.82128289
97MP0003943_abnormal_hepatobiliary_system0.81743398
98MP0002089_abnormal_postnatal_growth/wei0.80643434
99MP0004264_abnormal_extraembryonic_tissu0.80232338
100MP0001663_abnormal_digestive_system0.80193504
101MP0000639_abnormal_adrenal_gland0.78920878
102MP0002118_abnormal_lipid_homeostasis0.78464623
103MP0004742_abnormal_vestibular_system0.78067024
104MP0005666_abnormal_adipose_tissue0.77908328
105MP0003638_abnormal_response/metabolism_0.77592420
106MP0002896_abnormal_bone_mineralization0.76668663
107MP0001873_stomach_inflammation0.74652354
108MP0003959_abnormal_lean_body0.73192731
109MP0000467_abnormal_esophagus_morphology0.72832848
110MP0001986_abnormal_taste_sensitivity0.71921037
111MP0003890_abnormal_embryonic-extraembry0.71367634
112MP0001905_abnormal_dopamine_level0.71200229
113MP0002249_abnormal_larynx_morphology0.69949335
114MP0002064_seizures0.69759226
115MP0001485_abnormal_pinna_reflex0.69728870
116MP0002877_abnormal_melanocyte_morpholog0.69722717
117* MP0009642_abnormal_blood_homeostasis0.67776996
118MP0002796_impaired_skin_barrier0.67206773
119MP0008789_abnormal_olfactory_epithelium0.66897541
120MP0000534_abnormal_ureter_morphology0.65051327
121MP0003329_amyloid_beta_deposits0.64887431
122MP0009333_abnormal_splenocyte_physiolog0.64759697
123MP0000470_abnormal_stomach_morphology0.62341402
124MP0002572_abnormal_emotion/affect_behav0.60619250
125MP0002736_abnormal_nociception_after0.58607187
126MP0004084_abnormal_cardiac_muscle0.58053838
127MP0001968_abnormal_touch/_nociception0.56865914
128MP0009379_abnormal_foot_pigmentation0.56682460
129MP0010386_abnormal_urinary_bladder0.53764441
130MP0005220_abnormal_exocrine_pancreas0.53555755
131MP0003879_abnormal_hair_cell0.51258631
132MP0010329_abnormal_lipoprotein_level0.51213866
133MP0002069_abnormal_eating/drinking_beha0.49369655
134MP0009764_decreased_sensitivity_to0.48683221
135MP0000747_muscle_weakness0.48512060
136MP0004272_abnormal_basement_membrane0.48115010
137MP0001963_abnormal_hearing_physiology0.47334875
138MP0000678_abnormal_parathyroid_gland0.46650093
139MP0003172_abnormal_lysosome_physiology0.46251773
140MP0000609_abnormal_liver_physiology0.45332082
141MP0005165_increased_susceptibility_to0.45065237
142MP0001177_atelectasis0.44042640
143MP0005408_hypopigmentation0.43197608
144MP0002098_abnormal_vibrissa_morphology0.43019843
145MP0005501_abnormal_skin_physiology0.42711169
146MP0003795_abnormal_bone_structure0.41755793
147MP0004484_altered_response_of0.41574089
148MP0002078_abnormal_glucose_homeostasis0.41558598
149MP0008469_abnormal_protein_level0.41412125
150MP0002115_abnormal_skeleton_extremities0.39654567
151MP0001270_distended_abdomen0.37343440
152MP0000598_abnormal_liver_morphology0.36114277
153MP0003221_abnormal_cardiomyocyte_apopto0.35566699
154MP0001727_abnormal_embryo_implantation0.34466414
155MP0000920_abnormal_myelination0.31788063
156* MP0003953_abnormal_hormone_level0.31084543
157MP0000371_diluted_coat_color0.30849133
158MP0000163_abnormal_cartilage_morphology0.30806623
159MP0001664_abnormal_digestion0.30528677
160MP0006035_abnormal_mitochondrial_morpho0.29266470
161MP0004233_abnormal_muscle_weight0.27552880
162MP0000026_abnormal_inner_ear0.27544423
163MP0002998_abnormal_bone_remodeling0.27332652
164MP0000751_myopathy0.26542460
165MP0001731_abnormal_postnatal_growth0.26390180
166MP0005166_decreased_susceptibility_to0.25878674
167MP0003075_altered_response_to0.25848113

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)8.88220990
2Increased circulating renin level (HP:0000848)8.68203378
3Hypokalemic alkalosis (HP:0001949)8.56685088
4Hyperactive renin-angiotensin system (HP:0000841)7.89130734
5Abnormality of chloride homeostasis (HP:0011422)7.31175390
6* Hypomagnesemia (HP:0002917)7.19297798
7Gout (HP:0001997)7.13894518
8* Polyuria (HP:0000103)7.01524465
9* Abnormal urine output (HP:0012590)6.60985590
10* Abnormality of renal excretion (HP:0011036)6.09744187
11* Abnormality of magnesium homeostasis (HP:0004921)5.99992028
12Thyroid-stimulating hormone excess (HP:0002925)5.81922227
13Renal salt wasting (HP:0000127)5.80348302
14Hypothermia (HP:0002045)5.72094033
15Hyperaldosteronism (HP:0000859)5.66805361
16Abnormality of renin-angiotensin system (HP:0000847)5.37096463
17Alkalosis (HP:0001948)5.32633595
18* Abnormal drinking behavior (HP:0030082)5.17823830
19* Polydipsia (HP:0001959)5.17823830
20Proximal tubulopathy (HP:0000114)4.98580630
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.82750774
22* Tetany (HP:0001281)4.67310852
23Hyperglycinuria (HP:0003108)4.65907465
24Abnormal respiratory motile cilium morphology (HP:0005938)4.55196637
25Abnormal respiratory epithelium morphology (HP:0012253)4.55196637
26Abnormality of glutamine family amino acid metabolism (HP:0010902)4.49182980
27* Increased purine levels (HP:0004368)4.42570729
28* Hyperuricemia (HP:0002149)4.42570729
29Split foot (HP:0001839)4.35741653
30Abnormal respiratory motile cilium physiology (HP:0012261)4.35123154
31Dynein arm defect of respiratory motile cilia (HP:0012255)4.26923566
32Absent/shortened dynein arms (HP:0200106)4.26923566
33Hypokalemia (HP:0002900)4.21708967
34Abnormal ciliary motility (HP:0012262)4.21117190
35Fibular aplasia (HP:0002990)3.95405703
36Rhinitis (HP:0012384)3.90636111
37Ketoacidosis (HP:0001993)3.90154531
38Abnormality of glycine metabolism (HP:0010895)3.76812421
39Abnormality of serine family amino acid metabolism (HP:0010894)3.76812421
40* Abnormality of purine metabolism (HP:0004352)3.74944013
41Chronic bronchitis (HP:0004469)3.74502148
42Generalized aminoaciduria (HP:0002909)3.51304926
43* Hypercalciuria (HP:0002150)3.48326658
44Abnormality of midbrain morphology (HP:0002418)3.48115432
45Molar tooth sign on MRI (HP:0002419)3.48115432
46Abnormality of potassium homeostasis (HP:0011042)3.46885104
47Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.42465085
48Pancreatic cysts (HP:0001737)3.25739618
49Ketosis (HP:0001946)3.23682720
50Abnormality of fatty-acid metabolism (HP:0004359)3.23435095
51Humeroradial synostosis (HP:0003041)3.20233819
52Synostosis involving the elbow (HP:0003938)3.20233819
53Abnormality of urine glucose concentration (HP:0011016)3.14588492
54Glycosuria (HP:0003076)3.14588492
55Congenital stationary night blindness (HP:0007642)3.02587346
56Abnormality of sodium homeostasis (HP:0010931)3.00800732
57Pancreatic fibrosis (HP:0100732)2.99287487
58Focal segmental glomerulosclerosis (HP:0000097)2.94448508
59Chronic hepatic failure (HP:0100626)2.91641839
60Hyperphosphaturia (HP:0003109)2.91411069
61Bell-shaped thorax (HP:0001591)2.85716877
62Stomach cancer (HP:0012126)2.81564148
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.76216892
64Hyponatremia (HP:0002902)2.71732064
65Abnormality of proline metabolism (HP:0010907)2.71729549
66Hydroxyprolinuria (HP:0003080)2.71729549
67Abnormal urine phosphate concentration (HP:0012599)2.71195019
68True hermaphroditism (HP:0010459)2.69462514
69Bronchiectasis (HP:0002110)2.66544712
70Dehydration (HP:0001944)2.66029706
71Delayed CNS myelination (HP:0002188)2.64056640
72* Abnormality of nucleobase metabolism (HP:0010932)2.62735843
73Adrenal overactivity (HP:0002717)2.62191998
74Delayed epiphyseal ossification (HP:0002663)2.56231061
75Barrel-shaped chest (HP:0001552)2.54044207
76* Renal tubular acidosis (HP:0001947)2.53153780
77* Nephrocalcinosis (HP:0000121)2.50442928
78Spinal muscular atrophy (HP:0007269)2.50306043
79Abnormality of the vertebral endplates (HP:0005106)2.46954027
80Abnormality of the renal medulla (HP:0100957)2.44597833
81Conical tooth (HP:0000698)2.42278447
82Hyperglycinemia (HP:0002154)2.41425721
83* Nephrolithiasis (HP:0000787)2.34546162
84Hypophosphatemia (HP:0002148)2.34023784
85Nephronophthisis (HP:0000090)2.33966087
86Aplasia/hypoplasia of the uterus (HP:0008684)2.33789838
87Tubular atrophy (HP:0000092)2.32441432
88Vomiting (HP:0002013)2.29268120
89Chondrocalcinosis (HP:0000934)2.24223188
90Metabolic acidosis (HP:0001942)2.23994165
91Cystic liver disease (HP:0006706)2.22755984
92Facial shape deformation (HP:0011334)2.20971296
93Potter facies (HP:0002009)2.20971296
94Rickets (HP:0002748)2.20222166
95Confusion (HP:0001289)2.20205937
96Dicarboxylic aciduria (HP:0003215)2.19963593
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.19963593
98Chronic otitis media (HP:0000389)2.16982286
99Vascular calcification (HP:0004934)2.16834958
100Vacuolated lymphocytes (HP:0001922)2.16460947
101Oligodactyly (hands) (HP:0001180)2.16055006
102Enlarged kidneys (HP:0000105)2.16044445
103Stage 5 chronic kidney disease (HP:0003774)2.16040877
104Tubulointerstitial fibrosis (HP:0005576)2.15074653
105Decreased circulating renin level (HP:0003351)2.13026216
106Hyperammonemia (HP:0001987)2.12795045
107Widely patent fontanelles and sutures (HP:0004492)2.12409004
108Abnormality of sulfur amino acid metabolism (HP:0004339)2.12152663
109Abnormality of Sharpey fibers (HP:0100685)2.11923825
110Absence seizures (HP:0002121)2.11584514
111Aplasia/Hypoplasia of the sacrum (HP:0008517)2.10474533
112Enlarged epiphyses (HP:0010580)2.10360027
113Goiter (HP:0000853)2.10210870
114Abnormality of the pubic bones (HP:0003172)2.04294328
115Large for gestational age (HP:0001520)2.03743645
116Metaphyseal cupping (HP:0003021)2.02625348
117Abnormality of renal resorption (HP:0011038)1.99057461
118Abnormality of aromatic amino acid family metabolism (HP:0004338)1.98951885
119Hypotension (HP:0002615)1.98660004
120Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96493440
121Congenital hepatic fibrosis (HP:0002612)1.95532128
122Hyperventilation (HP:0002883)1.95325021
123Decreased central vision (HP:0007663)1.93530715
124Abnormality of the renal cortex (HP:0011035)1.93460566
125Malnutrition (HP:0004395)1.93317404
126Male pseudohermaphroditism (HP:0000037)1.92822753
127Occipital encephalocele (HP:0002085)1.92682333
128Cardiovascular calcification (HP:0011915)1.91957073
129Abnormal rod and cone electroretinograms (HP:0008323)1.91644402
130Lethargy (HP:0001254)1.88556822
131Degeneration of anterior horn cells (HP:0002398)1.86762446
132Abnormality of the anterior horn cell (HP:0006802)1.86762446
133Tachypnea (HP:0002789)1.86456693
134Stridor (HP:0010307)1.85506749
135Hypoplasia of the radius (HP:0002984)1.84772250
136Anencephaly (HP:0002323)1.84414012
137Hypoplastic iliac wings (HP:0002866)1.84260939
138Bicornuate uterus (HP:0000813)1.81353480
139Generalized muscle weakness (HP:0003324)1.79979039
140Amelogenesis imperfecta (HP:0000705)1.78544426
141Methylmalonic aciduria (HP:0012120)1.78001451
142Dialeptic seizures (HP:0011146)1.77881024
143Neonatal onset (HP:0003623)1.77168590
144Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.77103008
145Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76881624
146Glomerulosclerosis (HP:0000096)1.76540679
147Adactyly (HP:0009776)1.75283818
148Athetosis (HP:0002305)1.73384307
149Abnormal tarsal ossification (HP:0008369)1.73096581
150Irritability (HP:0000737)1.72639614
151Hoarse voice (HP:0001609)1.72100957
152Morphological abnormality of the middle ear (HP:0008609)1.69895692
153Bilateral sensorineural hearing impairment (HP:0008619)1.69458914
154Abnormal enzyme/coenzyme activity (HP:0012379)1.68966588
155Medial flaring of the eyebrow (HP:0010747)1.68859098
156Diaphragmatic weakness (HP:0009113)1.68073738
157Type II lissencephaly (HP:0007260)1.67563406
158Aplasia/Hypoplasia of the fibula (HP:0006492)1.66397892
159Pendular nystagmus (HP:0012043)1.66291177
160Polygenic inheritance (HP:0010982)1.66064034
161Aplasia/Hypoplasia of the tongue (HP:0010295)1.66015275
162Macroglossia (HP:0000158)1.65054517
163Aplasia/Hypoplasia of the ulna (HP:0006495)1.64421757
164Abnormality of alkaline phosphatase activity (HP:0004379)1.63215921
165Nausea (HP:0002018)1.62524856
166Thin bony cortex (HP:0002753)1.62371689
167Abnormality of carpal bone ossification (HP:0006257)1.61816303
168Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.61362346
169Abnormal eating behavior (HP:0100738)1.54873940
170* Renal tubular dysfunction (HP:0000124)1.54605390
171Lymphangioma (HP:0100764)1.49449351
172Axonal loss (HP:0003447)1.48805891
173Hyperkalemia (HP:0002153)1.47670552
174Metaphyseal dysplasia (HP:0100255)1.44904755
175Hypophosphatemic rickets (HP:0004912)1.44714989
176Metaphyseal irregularity (HP:0003025)1.44057969

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK39.92775370
2OXSR18.12264564
3WNK47.84605836
4TLK14.60851045
5STK393.98680555
6TAOK33.01329780
7EPHA22.53148357
8BCKDK2.44371214
9FRK2.30805877
10STK38L2.26403371
11ADRBK22.15275373
12SGK4941.89691890
13SGK2231.89691890
14NEK21.89125441
15WNK11.83230475
16EPHA31.81925414
17NEK11.68196949
18IKBKE1.64356042
19PDK41.63892164
20PDK31.63892164
21GRK11.41224728
22PDK21.39360319
23FGFR21.33455851
24NME11.24372287
25SGK21.21929745
26IRAK41.19139132
27PKN11.17257906
28MKNK21.16116477
29SGK31.15503409
30NTRK21.14227444
31STK381.11070078
32MST40.95621844
33MAP4K20.93430640
34CAMK10.92799390
35MST1R0.90047877
36IRAK10.88076921
37VRK10.87096900
38NUAK10.86698760
39ADRBK10.84283630
40MAPKAPK30.83085681
41PINK10.81036308
42STK240.80381685
43LRRK20.79716010
44ZAK0.76592856
45MAP2K70.75123340
46CHUK0.72108955
47IKBKB0.71867751
48TIE10.68247495
49ERBB20.67426752
50TBK10.66158527
51EIF2AK20.65159556
52GRK60.65156133
53BMPR1B0.64500298
54DAPK20.64331540
55LIMK10.63116365
56MARK20.62793528
57DYRK20.62269045
58MAP3K40.60945172
59MAPKAPK50.58941087
60ABL20.58163858
61PRKCE0.58097612
62GSK3A0.57249105
63EPHB10.56898960
64SGK10.56801393
65PRKCG0.56793612
66CAMK40.55768577
67FGFR40.55386655
68MAPK130.53984492
69CAMK2A0.53519841
70PTK20.53061134
71ILK0.52979812
72PRKAA10.50698568
73STK30.46898965
74PTK2B0.46413778
75SIK20.46097580
76STK100.45603916
77FER0.44595781
78RPS6KA60.44503815
79MAP2K60.44332911
80MAP3K70.44168742
81ERBB40.44003627
82CSF1R0.42885156
83RPS6KA50.41667197
84MET0.41049663
85MKNK10.40922231
86NTRK10.39069245
87EPHA40.38953175
88PAK30.38125231
89DMPK0.38059571
90PNCK0.37420001
91PDPK10.36727013
92MAP3K90.35662683
93PRKACB0.35575297
94CDK70.35516499
95ERN10.34192703
96MINK10.33822364
97TGFBR20.33249998
98PRKCI0.33034962
99PRKAA20.31817163
100PAK40.30970551
101MAP3K30.30763904
102AKT30.29084428
103PIK3CA0.28282182
104DYRK1B0.26569897
105PRKD20.25335049
106PRKCZ0.23753248
107MAPK110.23249638
108KSR20.23220860
109PDK10.22060217
110PTK60.19084921
111PRKCD0.18876914
112MAP3K60.18664309
113MAP3K20.17026928
114CSNK1G10.16841780
115MAP3K130.16151546
116INSRR0.15034059
117KSR10.14632698
118EPHB20.14180644
119PRKACA0.13799411
120PRKACG0.13450435
121SCYL20.12597437
122ROCK10.12474791
123MAPK150.11852017
124PRKCA0.11788163
125ROCK20.11659548
126PRKCQ0.11407429
127TRIB30.10805627
128CSNK1A10.10546420
129AKT20.10207669
130MYLK0.10034898
131JAK20.09439367
132PRKCH0.08718688
133TTK0.07908954
134MAP2K40.07071724
135BMPR20.06834032
136LMTK20.06673582
137STK110.06188948
138CDK50.04633137
139PIM10.04269796
140LATS10.04158438
141PAK60.03264943
142MAP3K140.02433959
143PRKD30.02125990
144BMX0.02041815
145MOS0.01478928
146MAP2K10.01240250
147LATS20.01161092
148SRC0.01136067
149IGF1R0.00848086
150RIPK40.00495512
151MARK3-0.0083129
152PDGFRA-0.0068895
153CDK19-0.0046044
154INSR-0.0030304
155CSNK1G2-0.0012464
156CSNK1A1L-0.0007905
157MAP3K8-0.0007692

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.01361886
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.88575694
3Butanoate metabolism_Homo sapiens_hsa006503.66871885
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.56917430
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.54783775
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.43077425
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.27171903
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.22428668
9Linoleic acid metabolism_Homo sapiens_hsa005913.21397089
10Propanoate metabolism_Homo sapiens_hsa006403.18891702
11Vitamin B6 metabolism_Homo sapiens_hsa007502.84542709
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.73131178
13Phototransduction_Homo sapiens_hsa047442.72415027
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.64328962
15Peroxisome_Homo sapiens_hsa041462.46294097
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.40025174
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.33706831
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.32704113
19Tryptophan metabolism_Homo sapiens_hsa003802.32118963
20Fatty acid degradation_Homo sapiens_hsa000712.26475671
21Vitamin digestion and absorption_Homo sapiens_hsa049772.24132815
22Collecting duct acid secretion_Homo sapiens_hsa049662.22333008
23Pyruvate metabolism_Homo sapiens_hsa006202.20901359
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16983404
25Salivary secretion_Homo sapiens_hsa049702.13402755
26Caffeine metabolism_Homo sapiens_hsa002322.09519571
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.09484826
28Bile secretion_Homo sapiens_hsa049761.87903061
29Sulfur metabolism_Homo sapiens_hsa009201.84346305
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.82210878
31beta-Alanine metabolism_Homo sapiens_hsa004101.81465557
32Glutathione metabolism_Homo sapiens_hsa004801.71842554
33Ether lipid metabolism_Homo sapiens_hsa005651.69560418
34Fatty acid metabolism_Homo sapiens_hsa012121.68682270
35Carbon metabolism_Homo sapiens_hsa012001.66270035
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.65353334
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64146744
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.61187085
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47783287
40African trypanosomiasis_Homo sapiens_hsa051431.44861792
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43660505
42Mineral absorption_Homo sapiens_hsa049781.41024242
43One carbon pool by folate_Homo sapiens_hsa006701.37150604
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36344316
45Protein digestion and absorption_Homo sapiens_hsa049741.31241845
46Arginine and proline metabolism_Homo sapiens_hsa003301.29994415
47Lysine degradation_Homo sapiens_hsa003101.29962850
48Arginine biosynthesis_Homo sapiens_hsa002201.26944901
49PPAR signaling pathway_Homo sapiens_hsa033201.23310747
50RNA polymerase_Homo sapiens_hsa030201.18616183
51Basal transcription factors_Homo sapiens_hsa030221.13920571
52Biosynthesis of amino acids_Homo sapiens_hsa012301.13892134
53Other glycan degradation_Homo sapiens_hsa005111.13649506
54Nitrogen metabolism_Homo sapiens_hsa009101.13401263
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11031239
56Selenocompound metabolism_Homo sapiens_hsa004501.05471574
57Nicotine addiction_Homo sapiens_hsa050331.05320116
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05150065
59* Tight junction_Homo sapiens_hsa045301.02995212
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97071496
61Oxidative phosphorylation_Homo sapiens_hsa001900.96827123
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.94451044
63Serotonergic synapse_Homo sapiens_hsa047260.92661685
64Homologous recombination_Homo sapiens_hsa034400.88374082
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.87961423
66Ribosome_Homo sapiens_hsa030100.87431386
67Folate biosynthesis_Homo sapiens_hsa007900.86881473
68Circadian entrainment_Homo sapiens_hsa047130.85118260
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83957467
70Renin-angiotensin system_Homo sapiens_hsa046140.81206876
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80250195
72Glycerolipid metabolism_Homo sapiens_hsa005610.78769680
73Fatty acid elongation_Homo sapiens_hsa000620.78644506
74Histidine metabolism_Homo sapiens_hsa003400.78377667
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77880729
76Starch and sucrose metabolism_Homo sapiens_hsa005000.77840916
77* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77326170
78Basal cell carcinoma_Homo sapiens_hsa052170.76751209
79Fructose and mannose metabolism_Homo sapiens_hsa000510.75625918
80Cocaine addiction_Homo sapiens_hsa050300.73783324
81Circadian rhythm_Homo sapiens_hsa047100.73393622
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69878636
83Ovarian steroidogenesis_Homo sapiens_hsa049130.67586960
84Phenylalanine metabolism_Homo sapiens_hsa003600.66352323
85Thyroid hormone synthesis_Homo sapiens_hsa049180.66058939
86Asthma_Homo sapiens_hsa053100.65437541
87Taste transduction_Homo sapiens_hsa047420.65023199
88Lysosome_Homo sapiens_hsa041420.60334590
89Gastric acid secretion_Homo sapiens_hsa049710.59598319
90Morphine addiction_Homo sapiens_hsa050320.56889984
91Chemical carcinogenesis_Homo sapiens_hsa052040.56164286
92Olfactory transduction_Homo sapiens_hsa047400.56147828
93Parkinsons disease_Homo sapiens_hsa050120.55689020
94* Hepatitis C_Homo sapiens_hsa051600.52580737
95Metabolic pathways_Homo sapiens_hsa011000.51930899
96Pentose phosphate pathway_Homo sapiens_hsa000300.50584771
97Fat digestion and absorption_Homo sapiens_hsa049750.50267357
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49740801
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47668286
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.43297802
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42095947
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42065508
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.41875797
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.39300205
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38770543
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.35975915
107Amphetamine addiction_Homo sapiens_hsa050310.34591241
108Hippo signaling pathway_Homo sapiens_hsa043900.32521963
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.32080183
110Purine metabolism_Homo sapiens_hsa002300.32074286
111Choline metabolism in cancer_Homo sapiens_hsa052310.31469734
112Insulin secretion_Homo sapiens_hsa049110.31145495
113Cardiac muscle contraction_Homo sapiens_hsa042600.30854054
114Synaptic vesicle cycle_Homo sapiens_hsa047210.30830293
115Vibrio cholerae infection_Homo sapiens_hsa051100.30829770
116Arachidonic acid metabolism_Homo sapiens_hsa005900.29971108
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29955325
118Alzheimers disease_Homo sapiens_hsa050100.29070176
119Autoimmune thyroid disease_Homo sapiens_hsa053200.26201128
120Glutamatergic synapse_Homo sapiens_hsa047240.25343929
121Retinol metabolism_Homo sapiens_hsa008300.25285481
122ECM-receptor interaction_Homo sapiens_hsa045120.24705258
123Tyrosine metabolism_Homo sapiens_hsa003500.23283498
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.22922654
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22034345
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21667950
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19460596
128Steroid biosynthesis_Homo sapiens_hsa001000.16699406
129Sulfur relay system_Homo sapiens_hsa041220.16410523
130Sphingolipid metabolism_Homo sapiens_hsa006000.14508594
131Huntingtons disease_Homo sapiens_hsa050160.12952901
132ABC transporters_Homo sapiens_hsa020100.10207737
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07529328
134Hedgehog signaling pathway_Homo sapiens_hsa043400.05918443
135Bladder cancer_Homo sapiens_hsa052190.05281060
136Inositol phosphate metabolism_Homo sapiens_hsa005620.04128311
137Rheumatoid arthritis_Homo sapiens_hsa053230.02497817
138Insulin resistance_Homo sapiens_hsa049310.02217322
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.00138128
140alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.1059769
141Pancreatic secretion_Homo sapiens_hsa04972-0.0936370
142Glucagon signaling pathway_Homo sapiens_hsa04922-0.0825267
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0786260
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0520665
145AMPK signaling pathway_Homo sapiens_hsa04152-0.0201520
146Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0137156

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