CLDN18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dichotomous subdivision of an epithelial terminal unit (GO:0060600)7.24456580
2cellular response to nitric oxide (GO:0071732)6.23683801
3negative regulation of complement activation (GO:0045916)5.93955817
4regulation of glomerular filtration (GO:0003093)5.91382538
5response to xenobiotic stimulus (GO:0009410)5.86926387
6induction of positive chemotaxis (GO:0050930)5.75785620
7positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003605.65081892
8regulation of integrin-mediated signaling pathway (GO:2001044)5.60937882
9positive regulation of endothelial cell differentiation (GO:0045603)5.58799920
10pattern specification involved in kidney development (GO:0061004)5.43439607
11lung lobe morphogenesis (GO:0060463)5.42108675
12negative regulation of digestive system process (GO:0060457)5.35985889
13regulation of vasculogenesis (GO:2001212)5.34246182
14negative regulation of protein activation cascade (GO:2000258)5.27003577
15peptide catabolic process (GO:0043171)5.13758128
16morphogenesis of an endothelium (GO:0003159)5.01229466
17endothelial tube morphogenesis (GO:0061154)5.01229466
18negative regulation of humoral immune response (GO:0002921)4.85263790
19regulation of cardioblast differentiation (GO:0051890)4.84966605
20epithelial tube branching involved in lung morphogenesis (GO:0060441)4.84139644
21renal system process involved in regulation of blood volume (GO:0001977)4.80023633
22cellular response to reactive nitrogen species (GO:1902170)4.77520926
23regulation of endothelial cell differentiation (GO:0045601)4.76749491
24response to nitric oxide (GO:0071731)4.62377172
25lung secretory cell differentiation (GO:0061140)4.58373795
26hemidesmosome assembly (GO:0031581)4.54462761
27endocardial cushion development (GO:0003197)4.50479372
28glomerular visceral epithelial cell development (GO:0072015)4.42617391
29glomerular epithelial cell development (GO:0072310)4.38268446
30phosphate ion transmembrane transport (GO:0035435)4.38260088
31positive regulation of vasculogenesis (GO:2001214)4.17578749
32lymphangiogenesis (GO:0001946)4.17283912
33respiratory tube development (GO:0030323)4.15888230
34sodium-independent organic anion transport (GO:0043252)4.14126651
35response to hyperoxia (GO:0055093)4.00303874
36response to increased oxygen levels (GO:0036296)4.00303874
37mesodermal cell differentiation (GO:0048333)3.98144742
38protein autoprocessing (GO:0016540)3.96838671
39regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.96718744
40lung vasculature development (GO:0060426)3.92375412
41positive regulation of positive chemotaxis (GO:0050927)3.70094468
42renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.69531598
43sodium ion homeostasis (GO:0055078)3.63297801
44response to vitamin A (GO:0033189)3.56243210
45cell adhesion mediated by integrin (GO:0033627)3.55970566
46phosphate ion transport (GO:0006817)3.55783495
47negative regulation of transcription by competitive promoter binding (GO:0010944)3.55598194
48regulation of phospholipid biosynthetic process (GO:0071071)3.54660048
49regulation of positive chemotaxis (GO:0050926)3.51253613
50respiratory gaseous exchange (GO:0007585)3.49111814
51glandular epithelial cell differentiation (GO:0002067)3.47341366
52response to interleukin-6 (GO:0070741)3.41830034
53renal absorption (GO:0070293)3.41822874
54lung alveolus development (GO:0048286)3.40381072
55embryonic foregut morphogenesis (GO:0048617)3.38904970
56endocrine hormone secretion (GO:0060986)3.38726482
57ethanol oxidation (GO:0006069)3.37208956
58peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.31263611
59branch elongation of an epithelium (GO:0060602)3.28806314
60atrioventricular valve morphogenesis (GO:0003181)3.28805390
61wound healing, spreading of epidermal cells (GO:0035313)3.27856578
62heart trabecula formation (GO:0060347)3.25777412
63embryonic digestive tract morphogenesis (GO:0048557)3.21241834
64toxin metabolic process (GO:0009404)3.19685614
65establishment of apical/basal cell polarity (GO:0035089)3.17599156
66cGMP biosynthetic process (GO:0006182)3.15427217
67epithelial cell differentiation involved in prostate gland development (GO:0060742)3.14676715
68regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.14514903
69sphingosine metabolic process (GO:0006670)3.14363810
70negative regulation of interleukin-2 production (GO:0032703)3.09903899
71axis elongation (GO:0003401)3.09415929
72glial cell proliferation (GO:0014009)3.08212707
73phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.07702853
74extracellular matrix assembly (GO:0085029)3.07197276
75adhesion of symbiont to host cell (GO:0044650)3.07066238
76virion attachment to host cell (GO:0019062)3.07066238
77digestion (GO:0007586)3.05451938
78positive regulation of digestive system process (GO:0060456)3.05043772
79macrophage chemotaxis (GO:0048246)3.04579682
80* tight junction assembly (GO:0070830)3.04544200
81regulation of podosome assembly (GO:0071801)3.02067676
82regulation of hippo signaling (GO:0035330)3.00257790
83negative regulation of epithelial to mesenchymal transition (GO:0010719)2.99899287
84neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.99264303
85regulation of interleukin-13 production (GO:0032656)2.97670160
86fatty acid derivative transport (GO:1901571)2.97007033
87icosanoid transport (GO:0071715)2.97007033
88positive regulation of chemokine secretion (GO:0090197)2.95903970
89regulation of tight junction assembly (GO:2000810)2.95608506
90cellular response to thyroid hormone stimulus (GO:0097067)2.95053041
91norepinephrine metabolic process (GO:0042415)2.93425064
92regulation of complement activation (GO:0030449)2.92364800
93regulation of digestive system process (GO:0044058)2.91302266
94organ formation (GO:0048645)2.90269024
95trivalent inorganic anion homeostasis (GO:0072506)2.87752495
96phosphate ion homeostasis (GO:0055062)2.87752495
97hyperosmotic salinity response (GO:0042538)2.87027458
98regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.86644415
99negative regulation of necroptotic process (GO:0060546)2.85864213
100regulation of necroptotic process (GO:0060544)2.85622644
101negative regulation of epidermal cell differentiation (GO:0045605)2.84706555
102Leydig cell differentiation (GO:0033327)2.83690844
103positive regulation of translational initiation (GO:0045948)2.82973801
104neuron remodeling (GO:0016322)2.82615104
105regulation of chemokine secretion (GO:0090196)2.80926439
106negative regulation of cell fate specification (GO:0009996)2.80554191
107positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.79691357
108positive regulation of cardiac muscle cell differentiation (GO:2000727)2.76853737
109one-carbon compound transport (GO:0019755)2.76686892
110blood vessel maturation (GO:0001955)2.76584680
111diol metabolic process (GO:0034311)2.75287579
112cellular response to antibiotic (GO:0071236)2.75278556
113lung cell differentiation (GO:0060479)2.74639554
114cellular hyperosmotic response (GO:0071474)2.72693053
115keratan sulfate catabolic process (GO:0042340)2.72336805
116mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.71579018
117cerebral cortex neuron differentiation (GO:0021895)2.69190011
118negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.68538463
119glomerular filtration (GO:0003094)2.66951294
120positive regulation of endothelial cell apoptotic process (GO:2000353)2.66674845
121regulation of protein activation cascade (GO:2000257)2.66587647
122renal filtration (GO:0097205)2.66478996
123regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.65483863
124cellular anion homeostasis (GO:0030002)2.63948998
125establishment or maintenance of monopolar cell polarity (GO:0061339)2.63800637
126establishment of monopolar cell polarity (GO:0061162)2.63800637
127branching involved in salivary gland morphogenesis (GO:0060445)2.63540800
128L-ascorbic acid metabolic process (GO:0019852)2.62207114
129endothelial cell chemotaxis (GO:0035767)2.62072980
130ethanol metabolic process (GO:0006067)2.61261463
131multicellular organismal water homeostasis (GO:0050891)2.59651202
132iron ion import (GO:0097286)2.58602031
133cellular response to BMP stimulus (GO:0071773)2.57921235
134response to BMP (GO:0071772)2.57921235
135negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.57360175
136lung epithelial cell differentiation (GO:0060487)2.57248043
137membrane raft organization (GO:0031579)2.56815762
138cellular sodium ion homeostasis (GO:0006883)2.56711716
139vascular endothelial growth factor signaling pathway (GO:0038084)2.56706831
140negative regulation of stress fiber assembly (GO:0051497)2.54768527
141labyrinthine layer blood vessel development (GO:0060716)2.54717836
142mesenchymal cell proliferation (GO:0010463)2.54251830
143establishment of epithelial cell polarity (GO:0090162)2.53969150
144positive regulation of p38MAPK cascade (GO:1900745)2.53918987
145intestinal epithelial cell development (GO:0060576)2.53629884
146negative regulation of alcohol biosynthetic process (GO:1902931)2.53560837
147positive regulation of hemostasis (GO:1900048)2.53400827
148positive regulation of blood coagulation (GO:0030194)2.53400827
149interleukin-6-mediated signaling pathway (GO:0070102)2.53228788
150polyol transport (GO:0015791)2.50574132
151cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.48377317
152columnar/cuboidal epithelial cell development (GO:0002066)2.46739285
153regulation of macrophage activation (GO:0043030)2.45119100
154glomerular basement membrane development (GO:0032836)2.42861857
155regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.42610634
156hydrogen peroxide biosynthetic process (GO:0050665)2.41488408
157surfactant homeostasis (GO:0043129)15.9488004
158chemical homeostasis within a tissue (GO:0048875)12.7868839

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.86328735
2GATA1_22025678_ChIP-Seq_K562_Human4.07165394
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.51254415
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.30569687
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.20694049
6ESR1_20079471_ChIP-ChIP_T-47D_Human3.08696908
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.89746271
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.85425082
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.81173570
10* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.75345811
11FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.63640959
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.56527682
13GATA2_21666600_ChIP-Seq_HMVEC_Human2.54529969
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.46463770
15PPAR_26484153_Chip-Seq_NCI-H1993_Human2.44794903
16AHR_22903824_ChIP-Seq_MCF-7_Human2.43126907
17ZNF217_24962896_ChIP-Seq_MCF-7_Human2.32348960
18SOX2_20726797_ChIP-Seq_SW620_Human2.30693353
19GATA4_25053715_ChIP-Seq_YYC3_Human2.27611027
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23545205
21CDX2_20551321_ChIP-Seq_CACO-2_Human2.19915738
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.17447261
23SALL4_18804426_ChIP-ChIP_XEN_Mouse2.03045319
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.02887694
25CLOCK_20551151_ChIP-Seq_293T_Human1.98984093
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.95988514
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.89424388
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.89424388
29ARNT_22903824_ChIP-Seq_MCF-7_Human1.73639867
30CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.71671042
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.71485183
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70824933
33FOXM1_26456572_ChIP-Seq_MCF-7_Human1.66972896
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.64371018
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61147693
36CJUN_26792858_Chip-Seq_BT549_Human1.61089104
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60004398
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59694517
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59040011
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58903333
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.57349208
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56598343
43JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56334677
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55694176
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54974686
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52363748
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.50691048
48SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48176894
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46272501
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44577373
51RUNX1_27514584_Chip-Seq_MCF-7_Human1.41036331
52TBX20_22328084_ChIP-Seq_HEART_Mouse1.39707836
53TBX20_22080862_ChIP-Seq_HEART_Mouse1.39707836
54LXR_22158963_ChIP-Seq_LIVER_Mouse1.39653279
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38014199
56GATA3_24758297_ChIP-Seq_MCF-7_Human1.35542755
57AR_21572438_ChIP-Seq_LNCaP_Human1.35177904
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34942217
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33826647
60RACK7_27058665_Chip-Seq_MCF-7_Human1.33618410
61GATA6_25053715_ChIP-Seq_YYC3_Human1.32717427
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.31037296
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.29763734
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29619072
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29467177
66* KLF5_25053715_ChIP-Seq_YYC3_Human1.28649998
67* SMAD4_21741376_ChIP-Seq_HESCs_Human1.27340559
68* SMAD3_21741376_ChIP-Seq_HESCs_Human1.26128321
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25388039
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25212638
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24830796
72TP53_18474530_ChIP-ChIP_U2OS_Human1.24398781
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24180272
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22899353
75JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21827941
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21373528
77ISL1_27105846_Chip-Seq_CPCs_Mouse1.21369722
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21144725
79FOXA2_19822575_ChIP-Seq_HepG2_Human1.18213426
80P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16328831
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15130606
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15130606
83SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.12566275
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11623357
85NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11585933
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10624795
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10193558
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09657452
89ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09476556
90EZH2_22144423_ChIP-Seq_EOC_Human1.07591729
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07294067
92TP63_23658742_ChIP-Seq_EP156T_Human1.06662945
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06186840
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05008675
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03966575
96PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03857084
97PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03193594
98SALL1_21062744_ChIP-ChIP_HESCs_Human1.01174202
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01090082
100MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01062357
101FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00888731
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00682718
103ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99514268
104NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98979836
105RXR_22158963_ChIP-Seq_LIVER_Mouse0.97480741
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96066957
107EGR1_19374776_ChIP-ChIP_THP-1_Human0.95171026
108NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94677962
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94570232
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94506196
111ELK3_25401928_ChIP-Seq_HUVEC_Human0.94212571
112CDX2_22108803_ChIP-Seq_LS180_Human0.92774261
113GATA1_19941826_ChIP-Seq_K562_Human0.91999387
114STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91671991
115RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91611948
116EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91611948
117SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91425556
118RXR_22108803_ChIP-Seq_LS180_Human0.91042258
119WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90610801
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.90609950
121VDR_24787735_ChIP-Seq_THP-1_Human0.90491083
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.90298775
123SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90181406
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88962593
125KDM2B_26808549_Chip-Seq_K562_Human0.87299298
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86651697
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86339855
128YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84288783
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83715563
130ATF3_27146783_Chip-Seq_COLON_Human0.82214023
131UBF1/2_26484160_Chip-Seq_HMECs_Human0.81962591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog6.86119438
2MP0008004_abnormal_stomach_pH6.78479873
3MP0001958_emphysema5.82583049
4MP0008995_early_reproductive_senescence5.17126728
5MP0005083_abnormal_biliary_tract3.96338689
6MP0010368_abnormal_lymphatic_system3.93910971
7MP0006054_spinal_hemorrhage3.21834991
8MP0001177_atelectasis2.87302729
9MP0002133_abnormal_respiratory_system2.69573009
10MP0005388_respiratory_system_phenotype2.69573009
11MP0004883_abnormal_blood_vessel2.67899041
12MP0003941_abnormal_skin_development2.61020648
13MP0001879_abnormal_lymphatic_vessel2.56622346
14MP0004272_abnormal_basement_membrane2.44043077
15MP0002138_abnormal_hepatobiliary_system2.34893828
16MP0001542_abnormal_bone_strength2.18110320
17MP0003191_abnormal_cellular_cholesterol2.13505148
18MP0002295_abnormal_pulmonary_circulatio1.95470102
19MP0000537_abnormal_urethra_morphology1.84287279
20MP0005503_abnormal_tendon_morphology1.79770841
21MP0003115_abnormal_respiratory_system1.78380845
22MP0005164_abnormal_response_to1.68720757
23MP0000566_synostosis1.67363264
24MP0009780_abnormal_chondrocyte_physiolo1.66011113
25MP0003950_abnormal_plasma_membrane1.64628086
26MP0001664_abnormal_digestion1.61287004
27MP0002132_abnormal_respiratory_system1.59605382
28MP0001175_abnormal_lung_morphology1.57118996
29MP0005167_abnormal_blood-brain_barrier1.42949293
30MP0003786_premature_aging1.41484262
31MP0003724_increased_susceptibility_to1.39754682
32MP0009384_cardiac_valve_regurgitation1.34285860
33MP0000470_abnormal_stomach_morphology1.27816702
34MP0005275_abnormal_skin_tensile1.26387016
35MP0008875_abnormal_xenobiotic_pharmacok1.26120112
36MP0003091_abnormal_cell_migration1.24998786
37MP0005595_abnormal_vascular_smooth1.24131972
38MP0009379_abnormal_foot_pigmentation1.22731245
39MP0003566_abnormal_cell_adhesion1.19603080
40MP0005408_hypopigmentation1.15417129
41MP0010234_abnormal_vibrissa_follicle1.12314218
42MP0005085_abnormal_gallbladder_physiolo1.11590473
43MP0001440_abnormal_grooming_behavior1.10697295
44MP0002277_abnormal_respiratory_mucosa1.08754369
45MP0000516_abnormal_urinary_system1.07248031
46MP0005367_renal/urinary_system_phenotyp1.07248031
47MP0001666_abnormal_nutrient_absorption1.06729368
48MP0001873_stomach_inflammation1.06198510
49MP0003705_abnormal_hypodermis_morpholog1.04805479
50MP0002098_abnormal_vibrissa_morphology1.02657880
51MP0010678_abnormal_skin_adnexa1.01206028
52MP0000462_abnormal_digestive_system0.99314097
53MP0005058_abnormal_lysosome_morphology0.95400210
54MP0002998_abnormal_bone_remodeling0.94919723
55MP0001986_abnormal_taste_sensitivity0.94708247
56MP0000383_abnormal_hair_follicle0.94598246
57MP0000249_abnormal_blood_vessel0.91905727
58MP0003119_abnormal_digestive_system0.90843824
59MP0002796_impaired_skin_barrier0.89756314
60MP0000767_abnormal_smooth_muscle0.89634169
61MP0005387_immune_system_phenotype0.86296505
62MP0001790_abnormal_immune_system0.86296505
63MP0005023_abnormal_wound_healing0.85807915
64MP0000534_abnormal_ureter_morphology0.85787317
65MP0003690_abnormal_glial_cell0.81705546
66MP0000681_abnormal_thyroid_gland0.81391630
67MP0002405_respiratory_system_inflammati0.81159592
68MP0003890_abnormal_embryonic-extraembry0.79952340
69MP0001501_abnormal_sleep_pattern0.78252046
70MP0005165_increased_susceptibility_to0.76446728
71MP0000013_abnormal_adipose_tissue0.75351416
72MP0001663_abnormal_digestive_system0.74238322
73MP0004264_abnormal_extraembryonic_tissu0.72626898
74MP0002136_abnormal_kidney_physiology0.72309777
75MP0008775_abnormal_heart_ventricle0.71624003
76MP0004036_abnormal_muscle_relaxation0.71424355
77MP0009643_abnormal_urine_homeostasis0.69448262
78MP0002925_abnormal_cardiovascular_devel0.67915549
79MP0004484_altered_response_of0.67254044
80MP0005409_darkened_coat_color0.66949321
81MP0002234_abnormal_pharynx_morphology0.66804583
82MP0010155_abnormal_intestine_physiology0.66708130
83MP0001851_eye_inflammation0.65891736
84MP0003938_abnormal_ear_development0.65141370
85MP0003828_pulmonary_edema0.64819236
86MP0000627_abnormal_mammary_gland0.64784087
87MP0001943_abnormal_respiration0.63441670
88MP0010352_gastrointestinal_tract_polyps0.63127037
89MP0004858_abnormal_nervous_system0.63079246
90MP0002139_abnormal_hepatobiliary_system0.62972038
91MP0000343_altered_response_to0.62747807
92MP0008438_abnormal_cutaneous_collagen0.62717449
93MP0002909_abnormal_adrenal_gland0.62429002
94MP0005248_abnormal_Harderian_gland0.61698703
95MP0003279_aneurysm0.58048263
96MP0009840_abnormal_foam_cell0.57898489
97MP0002282_abnormal_trachea_morphology0.57509755
98MP0000490_abnormal_crypts_of0.57376118
99MP0001881_abnormal_mammary_gland0.57085103
100MP0002135_abnormal_kidney_morphology0.56883123
101MP0001614_abnormal_blood_vessel0.55507866
102MP0002168_other_aberrant_phenotype0.54971793
103MP0002733_abnormal_thermal_nociception0.54518338
104MP0002254_reproductive_system_inflammat0.53546656
105MP0004085_abnormal_heartbeat0.51465869
106MP0003045_fibrosis0.49514975
107MP0002118_abnormal_lipid_homeostasis0.49060707
108MP0005257_abnormal_intraocular_pressure0.48838994
109MP0004185_abnormal_adipocyte_glucose0.48365562
110MP0006138_congestive_heart_failure0.48166319
111MP0003453_abnormal_keratinocyte_physiol0.48083739
112MP0005166_decreased_susceptibility_to0.48017374
113MP0001243_abnormal_dermal_layer0.47264357
114MP0001756_abnormal_urination0.46976649
115MP0002128_abnormal_blood_circulation0.46842672
116MP0004947_skin_inflammation0.46357833
117MP0003448_altered_tumor_morphology0.46343580
118MP0005508_abnormal_skeleton_morphology0.45789221
119MP0002009_preneoplasia0.45486036
120MP0005381_digestive/alimentary_phenotyp0.45439157
121MP0005397_hematopoietic_system_phenotyp0.45033292
122MP0001545_abnormal_hematopoietic_system0.45033292
123MP0005647_abnormal_sex_gland0.44782537
124MP0002108_abnormal_muscle_morphology0.44615695
125MP0003186_abnormal_redox_activity0.44073571
126MP0003942_abnormal_urinary_system0.43865091
127MP0003123_paternal_imprinting0.43049082
128MP0002060_abnormal_skin_morphology0.42625155
129MP0002166_altered_tumor_susceptibility0.40882766
130MP0001661_extended_life_span0.40573918
131MP0002332_abnormal_exercise_endurance0.40265465
132MP0004084_abnormal_cardiac_muscle0.38255026

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)7.05379399
2Tubulointerstitial fibrosis (HP:0005576)6.82873347
3Renal salt wasting (HP:0000127)6.00171138
4Chronic bronchitis (HP:0004469)5.96583093
5Onycholysis (HP:0001806)5.95961537
6Tachypnea (HP:0002789)5.52836660
7Abnormality of the fingertips (HP:0001211)5.52240042
8Gout (HP:0001997)5.16617302
9Respiratory distress (HP:0002098)4.93840330
10Tubulointerstitial nephritis (HP:0001970)4.65490455
11Hyperkalemia (HP:0002153)4.61439449
12Alveolar cell carcinoma (HP:0006519)4.38183273
13Broad metatarsal (HP:0001783)4.28551712
14Tubulointerstitial abnormality (HP:0001969)4.22973585
15Neoplasm of the tracheobronchial system (HP:0100552)4.09049758
16Vertebral arch anomaly (HP:0008438)3.91219749
17Azoospermia (HP:0000027)3.83175862
18Aortic aneurysm (HP:0004942)3.79963842
19Systemic lupus erythematosus (HP:0002725)3.59644916
20Glomerulonephritis (HP:0000099)3.48076987
21Neurofibrillary tangles (HP:0002185)3.46090632
22Polycythemia (HP:0001901)3.44864798
23Fragile nails (HP:0001808)3.43579722
24Thyroid-stimulating hormone excess (HP:0002925)3.34787708
25Abnormality of chloride homeostasis (HP:0011422)3.25573776
26Complement deficiency (HP:0004431)3.23275909
27Tubular atrophy (HP:0000092)3.22689350
28Hyperaldosteronism (HP:0000859)3.22059979
29Atrophic scars (HP:0001075)3.14641208
30Milia (HP:0001056)3.14126847
31Short nail (HP:0001799)3.04592072
32Hypotension (HP:0002615)3.00305435
33Hematochezia (HP:0002573)2.91874379
34Abnormality of the fetal cardiovascular system (HP:0010948)2.87700717
35Abnormal umbilical cord blood vessels (HP:0011403)2.87700717
36Single umbilical artery (HP:0001195)2.87700717
37Decreased circulating renin level (HP:0003351)2.87595653
38Exertional dyspnea (HP:0002875)2.79601795
39Shallow orbits (HP:0000586)2.78572249
40Aortic dissection (HP:0002647)2.77747743
41Absent eyebrow (HP:0002223)2.77208930
42Neonatal respiratory distress (HP:0002643)2.76686240
43Abnormality of renin-angiotensin system (HP:0000847)2.75807649
44Cerebral aneurysm (HP:0004944)2.75009228
45Abnormality of complement system (HP:0005339)2.67940172
46Vascular tortuosity (HP:0004948)2.65760062
47Midline defect of the nose (HP:0004122)2.62697071
48Cerebral inclusion bodies (HP:0100314)2.62648010
49Esophageal varix (HP:0002040)2.61412179
50Segmental peripheral demyelination/remyelination (HP:0003481)2.60668389
51Glomerulosclerosis (HP:0000096)2.57958557
52Abnormal number of erythroid precursors (HP:0012131)2.56203570
53Visceral angiomatosis (HP:0100761)2.55035927
54Nephritis (HP:0000123)2.54011408
55Increased purine levels (HP:0004368)2.53261889
56Hyperuricemia (HP:0002149)2.53261889
57Rectal prolapse (HP:0002035)2.52165237
58Abnormal spermatogenesis (HP:0008669)2.50004158
59Long toe (HP:0010511)2.47373988
60Abnormality of the lumbar spine (HP:0100712)2.46767317
61Neoplasm of the lung (HP:0100526)2.45696134
62Bronchitis (HP:0012387)2.44370842
63Ventricular fibrillation (HP:0001663)2.41909647
64Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.41060491
65Partial duplication of thumb phalanx (HP:0009944)2.40404006
66Absent eyelashes (HP:0000561)2.40004231
67Abnormality of the renal cortex (HP:0011035)2.39832912
68Ulnar claw (HP:0001178)2.38058353
69Thin bony cortex (HP:0002753)2.37888680
70Hyponatremia (HP:0002902)2.36837196
71Hemangiomatosis (HP:0007461)2.33515655
72Turricephaly (HP:0000262)2.33490501
73Spontaneous hematomas (HP:0007420)2.32894011
74Abnormality of the lacrimal duct (HP:0011481)2.31759267
75Pulmonary fibrosis (HP:0002206)2.30603605
76Abnormality of the nasal mucosa (HP:0000433)2.30505417
77Stomach cancer (HP:0012126)2.26742051
78Redundant skin (HP:0001582)2.26702485
79Right ventricular cardiomyopathy (HP:0011663)2.26016438
80Growth hormone excess (HP:0000845)2.25623769
81Camptodactyly of toe (HP:0001836)2.21197024
82Abnormality of cells of the erythroid lineage (HP:0012130)2.20943646
83Arterial tortuosity (HP:0005116)2.20013432
84Ulnar bowing (HP:0003031)2.18850953
85Striae distensae (HP:0001065)2.18599520
86Megaloblastic anemia (HP:0001889)2.17341048
87Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.17130991
88Bronchomalacia (HP:0002780)2.17019298
89Hypokalemic alkalosis (HP:0001949)2.15148272
90Congenital malformation of the right heart (HP:0011723)2.12902237
91Double outlet right ventricle (HP:0001719)2.12902237
92Stenosis of the external auditory canal (HP:0000402)2.10552296
93Renal hypoplasia (HP:0000089)2.10466508
94Glucose intolerance (HP:0000833)2.10421760
95Neoplasm of the heart (HP:0100544)2.10339648
96Abnormality of the nasolacrimal system (HP:0000614)2.08612783
97Hypergammaglobulinemia (HP:0010702)2.08392570
98Neoplasm of the respiratory system (HP:0100606)2.08212807
99Thoracic kyphosis (HP:0002942)2.02907959
100Abnormality of the vitamin B12 metabolism (HP:0004341)2.02847439
101Plantar hyperkeratosis (HP:0007556)2.02227495
102Partial duplication of the phalanx of hand (HP:0009999)2.00847082
103Interstitial pulmonary disease (HP:0006530)11.2692323
104Eczematoid dermatitis (HP:0000976)1.98079051
105Abnormality of the gastric mucosa (HP:0004295)1.97998728
106Pulmonary hypertension (HP:0002092)1.94872828
107Hypoplasia of dental enamel (HP:0006297)1.94707170
108Abnormality of purine metabolism (HP:0004352)1.93092434
109Abnormality of vitamin metabolism (HP:0100508)1.92790033
110Beaking of vertebral bodies (HP:0004568)1.91926886
111Aneurysm (HP:0002617)1.91528655
112Increased CSF protein (HP:0002922)1.91453379
113Abnormality of vitamin B metabolism (HP:0004340)1.90300552
114Adrenal overactivity (HP:0002717)1.88944099
115Malnutrition (HP:0004395)1.87673170
116Lymphangioma (HP:0100764)1.86513735
117Abnormal cartilage morphology (HP:0002763)1.83459136
118Cortical dysplasia (HP:0002539)1.83012942
119Aplasia involving bones of the extremities (HP:0009825)1.82773610
120Aplasia involving bones of the upper limbs (HP:0009823)1.82773610
121Aplasia of the phalanges of the hand (HP:0009802)1.82773610
122Mesomelia (HP:0003027)1.82107028
123Loss of speech (HP:0002371)1.81962895
124Choanal stenosis (HP:0000452)1.81796384
125Abnormality of sodium homeostasis (HP:0010931)1.81114626
126Anophthalmia (HP:0000528)1.80822521
127Skull defect (HP:0001362)1.78433413
128Xerostomia (HP:0000217)1.77260209
129Osteolytic defects of the phalanges of the hand (HP:0009771)1.76881079
130Osteolytic defects of the hand bones (HP:0009699)1.76881079
131Abnormal pancreas size (HP:0012094)1.76509697
132Short 4th metacarpal (HP:0010044)1.76089994
133Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.76089994
134Mitral valve prolapse (HP:0001634)1.75805489
135Broad ribs (HP:0000885)1.75721179
136Stage 5 chronic kidney disease (HP:0003774)1.75386084
137Abnormality of the epiphyses of the hand (HP:0005924)1.75240302
138Palpebral edema (HP:0100540)1.74931471
139Curly hair (HP:0002212)1.74482392
140Esophageal atresia (HP:0002032)1.74067931
141Pulmonary artery stenosis (HP:0004415)1.73208454
142Dehydration (HP:0001944)1.72832510
143Bowed forearm bones (HP:0003956)1.70217307
144Bowing of the arm (HP:0006488)1.70217307
145Severe Myopia (HP:0011003)1.70148955
146Progressive sensorineural hearing impairment (HP:0000408)1.69136379
147Abnormality of the thoracic spine (HP:0100711)1.69024522
148Bronchiectasis (HP:0002110)1.68812918
149Abnormality of macrophages (HP:0004311)1.68783729
150Radial bowing (HP:0002986)1.67718543
151Subacute progressive viral hepatitis (HP:0006572)1.67551256
152Shawl scrotum (HP:0000049)1.67070655
153Cupped ear (HP:0000378)1.65024134
154Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.62400531
155Hyperpituitarism (HP:0010514)1.58879230
156Joint contractures involving the joints of the feet (HP:0100492)1.57761894
157Flexion contracture of toe (HP:0005830)1.57761894
158Disproportionate tall stature (HP:0001519)1.54719594
159Skin nodule (HP:0200036)1.52247122
160Wormian bones (HP:0002645)1.51902615
161Rapidly progressive (HP:0003678)1.50725552
162Abnormal glucose tolerance (HP:0001952)1.50656374
163Submucous cleft hard palate (HP:0000176)1.49945087
164Dilatation of the ascending aorta (HP:0005111)1.48409194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK15.06374227
2PIK3CG4.47207055
3TGFBR23.92460210
4TIE13.42378123
5TESK13.41182220
6STK243.27427581
7MST43.22156669
8MAP3K33.18453230
9FGFR22.86973469
10LRRK22.80236175
11EPHB22.74641082
12DAPK22.41208084
13LMTK22.33214269
14ZAP702.32127787
15LIMK12.31907049
16STK102.29318694
17EPHA22.23195022
18PAK42.09668494
19TAOK22.00727225
20MAP2K31.86345500
21NUAK11.85296354
22ERBB41.84832254
23TAOK11.84792809
24ILK1.80834162
25EPHB11.74052616
26STK38L1.71585391
27MST1R1.64595244
28MAP3K111.62619620
29MAP3K121.57464022
30TRIB31.55731451
31NLK1.54240582
32PDGFRB1.51408487
33MAP3K21.50574962
34FER1.49924443
35RIPK11.46276572
36MYLK1.45178741
37RPS6KA21.42285878
38MARK21.30080033
39TGFBR11.24026163
40GRK11.22949579
41MAP3K61.22597845
42CDC42BPA1.21881591
43PTK61.21643648
44PDPK11.16643073
45IRAK11.14544187
46ERN11.10546085
47ERBB31.06798868
48NEK91.00319374
49SGK21.00277797
50SGK30.98625432
51JAK10.98494654
52LATS10.95175087
53CDK60.87009947
54PBK0.85437799
55MAP2K10.84716045
56CSK0.84451378
57RPS6KA40.84218017
58BCR0.83557072
59PTK20.82010988
60MAP2K20.80790476
61EGFR0.78961848
62MET0.78159518
63MAP3K10.76709611
64PRPF4B0.75561665
65LATS20.72667962
66GSK3A0.70985729
67GRK70.70420662
68MAPK70.65593803
69KSR20.64254548
70SGK2230.62932719
71SGK4940.62932719
72MELK0.60828747
73CHUK0.60777927
74FGFR40.59605220
75PRKD10.59271360
76PRKG20.58394415
77ROCK20.56184229
78NTRK30.56183379
79MAP3K140.56039185
80ERBB20.55848290
81MAP2K60.55169678
82SIK10.54882748
83RET0.54432197
84NME10.54051267
85MAPK150.53725262
86PRKCQ0.53701001
87ROCK10.51787530
88YES10.50693500
89PIM20.50513982
90STK30.50156089
91PDK20.49573828
92AKT30.48478190
93PRKCE0.46846086
94EEF2K0.46666736
95FGFR30.45907085
96DAPK30.44691886
97MAP3K80.44691881
98TYK20.44658393
99BLK0.43507456
100PKN20.43089033
101GRK50.42724597
102FRK0.41888230
103RPS6KA60.41560179
104KIT0.41432765
105MAP3K90.40740058
106STK390.40646129
107WNK40.39004187
108MAPK30.38094124
109PDGFRA0.37581140
110NTRK10.37499361
111TAOK30.37234249
112KDR0.36016078
113INSR0.35674126
114SIK30.35467615
115PAK20.34951518
116FYN0.34243390
117MAPK120.33092608
118STK380.32682897
119ACVR1B0.32549881
120MOS0.32414784
121MTOR0.32407816
122MAP3K130.31383362
123IGF1R0.31233504
124MAPK10.30308522
125EPHA30.30287423
126HIPK20.29958434
127MAP3K70.29324522
128ABL10.29141704
129FGFR10.28052336
130DYRK1B0.26352255
131RPS6KC10.26126749
132RPS6KL10.26126749
133DDR20.25133807
134DMPK0.25024610
135PRKCH0.23271545
136TRPM70.22743653
137MARK30.21892162

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045203.22341153
2Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.13313686
3ECM-receptor interaction_Homo sapiens_hsa045122.83087271
4Mineral absorption_Homo sapiens_hsa049782.70208959
5AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.40586065
6Hippo signaling pathway_Homo sapiens_hsa043902.37125828
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.35366009
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.30032118
9* Tight junction_Homo sapiens_hsa045302.29024410
10Bladder cancer_Homo sapiens_hsa052192.25066668
11Sulfur metabolism_Homo sapiens_hsa009202.09996825
12* Leukocyte transendothelial migration_Homo sapiens_hsa046701.87720199
13Glutathione metabolism_Homo sapiens_hsa004801.75824891
14Vitamin digestion and absorption_Homo sapiens_hsa049771.74621551
15Focal adhesion_Homo sapiens_hsa045101.71625627
16Staphylococcus aureus infection_Homo sapiens_hsa051501.62821626
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.61176081
18Chemical carcinogenesis_Homo sapiens_hsa052041.60720237
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.59922329
20Gastric acid secretion_Homo sapiens_hsa049711.59373449
21Lysosome_Homo sapiens_hsa041421.58467026
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57902212
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.51082530
24Small cell lung cancer_Homo sapiens_hsa052221.48814031
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.48001107
26Proteoglycans in cancer_Homo sapiens_hsa052051.45963817
27* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.40914515
28Thyroid cancer_Homo sapiens_hsa052161.40807889
29Amoebiasis_Homo sapiens_hsa051461.40756582
30Collecting duct acid secretion_Homo sapiens_hsa049661.40066922
31Basal cell carcinoma_Homo sapiens_hsa052171.39752279
32TGF-beta signaling pathway_Homo sapiens_hsa043501.36845619
33Vibrio cholerae infection_Homo sapiens_hsa051101.30594891
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26753854
35Rap1 signaling pathway_Homo sapiens_hsa040151.23757484
36Fatty acid biosynthesis_Homo sapiens_hsa000611.22424559
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22003473
38Linoleic acid metabolism_Homo sapiens_hsa005911.20295062
39Caffeine metabolism_Homo sapiens_hsa002321.19114575
40Ether lipid metabolism_Homo sapiens_hsa005651.14067651
41Endometrial cancer_Homo sapiens_hsa052131.12223881
42Axon guidance_Homo sapiens_hsa043601.11132412
43Ovarian steroidogenesis_Homo sapiens_hsa049131.09995574
44Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05410132
45Viral myocarditis_Homo sapiens_hsa054161.04714399
46Circadian rhythm_Homo sapiens_hsa047101.03986141
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02626309
48Phagosome_Homo sapiens_hsa041451.02153500
49Histidine metabolism_Homo sapiens_hsa003401.01706572
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00938709
51Toxoplasmosis_Homo sapiens_hsa051450.99028949
52Fatty acid degradation_Homo sapiens_hsa000710.97912571
53Arachidonic acid metabolism_Homo sapiens_hsa005900.95870481
54Pancreatic cancer_Homo sapiens_hsa052120.94938915
55Pertussis_Homo sapiens_hsa051330.94663230
56Other glycan degradation_Homo sapiens_hsa005110.93004438
57VEGF signaling pathway_Homo sapiens_hsa043700.92138279
58Taste transduction_Homo sapiens_hsa047420.92062394
59Platelet activation_Homo sapiens_hsa046110.91402415
60ABC transporters_Homo sapiens_hsa020100.91008117
61Pathways in cancer_Homo sapiens_hsa052000.90776286
62Asthma_Homo sapiens_hsa053100.89837425
63Endocytosis_Homo sapiens_hsa041440.89598845
64Tryptophan metabolism_Homo sapiens_hsa003800.88229976
65Fatty acid elongation_Homo sapiens_hsa000620.86741746
66Renin-angiotensin system_Homo sapiens_hsa046140.86209751
67Malaria_Homo sapiens_hsa051440.86179718
68Thyroid hormone synthesis_Homo sapiens_hsa049180.84905099
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84844212
70Melanogenesis_Homo sapiens_hsa049160.81940422
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80695570
72Glycerolipid metabolism_Homo sapiens_hsa005610.80217831
73Hedgehog signaling pathway_Homo sapiens_hsa043400.77882321
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.74747208
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74606514
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73789851
77Notch signaling pathway_Homo sapiens_hsa043300.72903280
78Renal cell carcinoma_Homo sapiens_hsa052110.72526913
79Dilated cardiomyopathy_Homo sapiens_hsa054140.71306412
80Choline metabolism in cancer_Homo sapiens_hsa052310.69930973
81Chronic myeloid leukemia_Homo sapiens_hsa052200.69710269
82Salmonella infection_Homo sapiens_hsa051320.69515847
83Oxytocin signaling pathway_Homo sapiens_hsa049210.66093304
84Graft-versus-host disease_Homo sapiens_hsa053320.65123079
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.64983467
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63350666
87Complement and coagulation cascades_Homo sapiens_hsa046100.63085908
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62716907
89MicroRNAs in cancer_Homo sapiens_hsa052060.62716897
90Serotonergic synapse_Homo sapiens_hsa047260.60948900
91Prion diseases_Homo sapiens_hsa050200.58147024
92Sphingolipid metabolism_Homo sapiens_hsa006000.58063435
93Prostate cancer_Homo sapiens_hsa052150.57805405
94Apoptosis_Homo sapiens_hsa042100.57575331
95MAPK signaling pathway_Homo sapiens_hsa040100.57180983
96Peroxisome_Homo sapiens_hsa041460.57180642
97Sulfur relay system_Homo sapiens_hsa041220.56978917
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56023600
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55303711
100Retinol metabolism_Homo sapiens_hsa008300.54969451
101Influenza A_Homo sapiens_hsa051640.54805372
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54666532
103Shigellosis_Homo sapiens_hsa051310.53596021
104Tyrosine metabolism_Homo sapiens_hsa003500.53554508
105Dorso-ventral axis formation_Homo sapiens_hsa043200.52764768
106Insulin resistance_Homo sapiens_hsa049310.51645066
107Allograft rejection_Homo sapiens_hsa053300.50927141
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50595326
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50480895
110Bile secretion_Homo sapiens_hsa049760.49903803
111Phenylalanine metabolism_Homo sapiens_hsa003600.49559140
112Leishmaniasis_Homo sapiens_hsa051400.48893841
113Protein digestion and absorption_Homo sapiens_hsa049740.48851994
114Autoimmune thyroid disease_Homo sapiens_hsa053200.47733368
115Long-term depression_Homo sapiens_hsa047300.46942239
116Osteoclast differentiation_Homo sapiens_hsa043800.46809056
117TNF signaling pathway_Homo sapiens_hsa046680.45220103
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.45068952
119Colorectal cancer_Homo sapiens_hsa052100.44616380
120Selenocompound metabolism_Homo sapiens_hsa004500.44488393
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.43937998
122Salivary secretion_Homo sapiens_hsa049700.43118777
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43029992
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42825178
125Melanoma_Homo sapiens_hsa052180.42789508
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42585630
127Renin secretion_Homo sapiens_hsa049240.42432372
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.42238424
129* Hepatitis C_Homo sapiens_hsa051600.41927215
130GnRH signaling pathway_Homo sapiens_hsa049120.41820362
131ErbB signaling pathway_Homo sapiens_hsa040120.40934462
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40625158
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39207266
134Fatty acid metabolism_Homo sapiens_hsa012120.38597948
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.36754449
136Rheumatoid arthritis_Homo sapiens_hsa053230.36547185
137PPAR signaling pathway_Homo sapiens_hsa033200.33691580
138Pancreatic secretion_Homo sapiens_hsa049720.32674305

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