CLDN20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host cellular process (GO:0044068)8.26228458
2negative regulation of viral entry into host cell (GO:0046597)7.97964490
3phosphatidylinositol acyl-chain remodeling (GO:0036149)7.85714455
4phenol-containing compound catabolic process (GO:0019336)7.68235744
5phosphatidylserine acyl-chain remodeling (GO:0036150)7.54781930
6neutrophil activation involved in immune response (GO:0002283)7.30926970
7negative regulation of viral release from host cell (GO:1902187)6.67163760
8regulation of viral entry into host cell (GO:0046596)6.20481563
9regulation of translational elongation (GO:0006448)5.98526216
10phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.57016386
11coenzyme catabolic process (GO:0009109)5.42169340
12negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)5.40469437
13DNA unwinding involved in DNA replication (GO:0006268)5.21438595
14skin morphogenesis (GO:0043589)4.94959501
15DNA replication checkpoint (GO:0000076)4.83446831
16phosphatidylcholine acyl-chain remodeling (GO:0036151)4.80712700
17protein localization to kinetochore (GO:0034501)4.60510031
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.53804348
19macrophage activation involved in immune response (GO:0002281)4.53227975
20regulation of establishment of cell polarity (GO:2000114)4.52496103
21regulation of nuclear cell cycle DNA replication (GO:0033262)4.41976611
22phosphatidylserine metabolic process (GO:0006658)4.41925576
23negative regulation of DNA repair (GO:0045738)4.23009170
24lymphoid progenitor cell differentiation (GO:0002320)4.17095942
25alpha-linolenic acid metabolic process (GO:0036109)4.11830711
26modulation by virus of host morphology or physiology (GO:0019048)4.05801212
27vesicle targeting (GO:0006903)3.95416655
28replicative senescence (GO:0090399)3.91515017
29RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.80925734
30mitotic sister chromatid segregation (GO:0000070)3.79137980
31positive regulation of synapse maturation (GO:0090129)3.78498322
32regulation of viral release from host cell (GO:1902186)3.77178663
33sister chromatid segregation (GO:0000819)3.67751283
34cerebellar granule cell differentiation (GO:0021707)3.67303488
35cellular modified amino acid catabolic process (GO:0042219)3.64579006
36regulation of establishment or maintenance of cell polarity (GO:0032878)3.63643204
37negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.62799084
38positive regulation of cell cycle checkpoint (GO:1901978)3.56653016
39tooth mineralization (GO:0034505)3.53098984
40folic acid-containing compound biosynthetic process (GO:0009396)3.52217825
41heterochromatin organization (GO:0070828)3.52155276
42cofactor catabolic process (GO:0051187)3.50234874
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.50041429
44L-phenylalanine catabolic process (GO:0006559)3.50041429
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.49926263
46alditol phosphate metabolic process (GO:0052646)3.49076649
47termination of RNA polymerase II transcription (GO:0006369)3.47381551
48proline transport (GO:0015824)3.45722679
49mRNA transport (GO:0051028)3.44559567
50negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.44464905
51histone H2B ubiquitination (GO:0033523)3.44119528
52polyketide metabolic process (GO:0030638)3.42121373
53doxorubicin metabolic process (GO:0044598)3.42121373
54daunorubicin metabolic process (GO:0044597)3.42121373
55pore complex assembly (GO:0046931)3.41989806
56glutamate secretion (GO:0014047)3.41703383
57monoubiquitinated protein deubiquitination (GO:0035520)3.40931710
58beta-amyloid metabolic process (GO:0050435)3.35127334
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.34381906
60erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.32955046
61L-phenylalanine metabolic process (GO:0006558)3.32955046
62histone mRNA catabolic process (GO:0071044)3.30804911
63positive regulation of receptor recycling (GO:0001921)3.27893760
64regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.26945785
65mitotic chromosome condensation (GO:0007076)3.26881011
66sulfur amino acid catabolic process (GO:0000098)3.26821316
67regulation of mitotic spindle checkpoint (GO:1903504)3.26760545
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.26760545
69regulation of meiosis I (GO:0060631)3.20526228
70regulation of fatty acid beta-oxidation (GO:0031998)3.20037742
71protein localization to chromosome, centromeric region (GO:0071459)3.16769184
72negative regulation of cell cycle G2/M phase transition (GO:1902750)3.14623576
73chromatin assembly (GO:0031497)3.13508585
74regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.13097483
75DNA replication-dependent nucleosome assembly (GO:0006335)3.12810342
76DNA replication-dependent nucleosome organization (GO:0034723)3.12810342
77somite rostral/caudal axis specification (GO:0032525)3.11760403
78negative regulation of DNA-dependent DNA replication (GO:2000104)3.11690167
79nucleobase catabolic process (GO:0046113)3.11496195
80behavioral response to ethanol (GO:0048149)3.08952160
81nucleic acid transport (GO:0050657)3.07548543
82RNA transport (GO:0050658)3.07548543
83establishment of RNA localization (GO:0051236)3.07548543
84regulation of response to osmotic stress (GO:0047484)3.05600776
85cell migration involved in gastrulation (GO:0042074)3.04064302
86peroxisome fission (GO:0016559)3.01013906
87neurotransmitter uptake (GO:0001504)3.00366309
88T cell activation involved in immune response (GO:0002286)3.00010616
89response to pheromone (GO:0019236)2.99850409
90amyloid precursor protein catabolic process (GO:0042987)2.99846173
91negative regulation of receptor activity (GO:2000272)2.99319502
92C4-dicarboxylate transport (GO:0015740)2.95742989
93mRNA export from nucleus (GO:0006406)2.95271306
94attachment of spindle microtubules to kinetochore (GO:0008608)2.95183934
95T cell lineage commitment (GO:0002360)2.92492244
96cellular ketone body metabolic process (GO:0046950)2.92179360
97histone-serine phosphorylation (GO:0035404)2.91741050
98rRNA catabolic process (GO:0016075)2.91620151
99negative regulation of meiotic cell cycle (GO:0051447)2.90745272
100glutamine metabolic process (GO:0006541)2.89372343
101regulation of centriole replication (GO:0046599)2.89301769
102hematopoietic stem cell differentiation (GO:0060218)2.88503504
103regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.88139168
104oxaloacetate metabolic process (GO:0006107)2.86669176
105RNA export from nucleus (GO:0006405)2.85909136
106L-methionine salvage (GO:0071267)2.84996486
107L-methionine biosynthetic process (GO:0071265)2.84996486
108amino acid salvage (GO:0043102)2.84996486
109histone H3-K9 methylation (GO:0051567)2.84755679
110pericardium development (GO:0060039)2.84376759
111regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.82779144
112nuclear pore complex assembly (GO:0051292)2.82674155
113hormone catabolic process (GO:0042447)2.82428746
114pteridine-containing compound biosynthetic process (GO:0042559)2.82202510
115one-carbon metabolic process (GO:0006730)2.82134529
116pre-miRNA processing (GO:0031054)2.82005643
117positive regulation of fatty acid beta-oxidation (GO:0032000)2.81234432
118female gonad development (GO:0008585)2.80983229
119aromatic amino acid family catabolic process (GO:0009074)2.80185374
120basic amino acid transport (GO:0015802)2.79999298
121neurotransmitter secretion (GO:0007269)2.79718453
122neutrophil activation (GO:0042119)2.79402099
123regulation of cholesterol homeostasis (GO:2000188)2.78386144
124CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.78328439
125negative regulation of meiosis (GO:0045835)2.77270737
126maintenance of protein location in nucleus (GO:0051457)2.77039834
127tyrosine metabolic process (GO:0006570)2.76719826
128multicellular organism reproduction (GO:0032504)2.74309695
129DNA duplex unwinding (GO:0032508)2.73697817
130ovulation cycle (GO:0042698)2.71171853
131histone H3-K4 trimethylation (GO:0080182)2.69716751
132modification by symbiont of host morphology or physiology (GO:0044003)2.69712639
133negative regulation of protein tyrosine kinase activity (GO:0061099)2.69457448
134sympathetic nervous system development (GO:0048485)2.69065494
135DNA geometric change (GO:0032392)2.68567708
136amino acid activation (GO:0043038)2.66752941
137tRNA aminoacylation (GO:0043039)2.66752941
138regulation of response to food (GO:0032095)2.65850407
139pyrimidine nucleobase catabolic process (GO:0006208)2.65269261
140positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.65056899
141Arp2/3 complex-mediated actin nucleation (GO:0034314)2.64309418
142transcription from RNA polymerase III promoter (GO:0006383)2.63998803
143heme transport (GO:0015886)2.62678377
144regulation of DNA methylation (GO:0044030)2.62232109
145apical protein localization (GO:0045176)2.62208462
146epoxygenase P450 pathway (GO:0019373)2.61480218
147nuclear pore organization (GO:0006999)2.61473238
148positive regulation of translation (GO:0045727)2.61353811
149glycogen catabolic process (GO:0005980)2.61206563
150fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.61009210
151nucleobase-containing compound transport (GO:0015931)2.60952294
152negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.59709178
153negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.59709178
154negative regulation of mitotic sister chromatid segregation (GO:0033048)2.59709178
155negative regulation of mitotic sister chromatid separation (GO:2000816)2.59709178
156negative regulation of sister chromatid segregation (GO:0033046)2.59709178
157regulation of synaptic vesicle exocytosis (GO:2000300)2.59526278
158response to water (GO:0009415)2.59431604
159regulation of regulatory T cell differentiation (GO:0045589)2.58789781
160regulation of mammary gland epithelial cell proliferation (GO:0033599)2.57872793
161positive regulation of SMAD protein import into nucleus (GO:0060391)2.57281745
162regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.57204099
163natural killer cell mediated immunity (GO:0002228)2.56101256
164natural killer cell mediated cytotoxicity (GO:0042267)2.56101256
165DNA strand elongation involved in DNA replication (GO:0006271)2.56086207
166DNA replication initiation (GO:0006270)2.56039515
167negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.55534565
168hemidesmosome assembly (GO:0031581)2.55208995
169tRNA aminoacylation for protein translation (GO:0006418)2.54908690
170negative regulation of chromosome segregation (GO:0051985)2.53754749
171mitotic spindle checkpoint (GO:0071174)2.53692201
172kynurenine metabolic process (GO:0070189)2.53354853
173regulation of synapse maturation (GO:0090128)2.53265701
174positive regulation of DNA-dependent DNA replication (GO:2000105)2.53195259
175mitotic spindle assembly checkpoint (GO:0007094)2.53091613
176spindle assembly checkpoint (GO:0071173)2.52543134
177histone H3-K36 demethylation (GO:0070544)2.52524139
178regulation of cardiac muscle cell apoptotic process (GO:0010665)2.52008247
179regulation of alkaline phosphatase activity (GO:0010692)2.51280851
180protein localization to synapse (GO:0035418)2.50751308
181regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.48726824
182synaptic vesicle maturation (GO:0016188)2.46763125
183glucan catabolic process (GO:0009251)2.45510454
184regulation of cytokine production involved in inflammatory response (GO:1900015)2.45410517
185chromosome condensation (GO:0030261)2.45262851
186positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.45208620
187ketone body metabolic process (GO:1902224)2.43939675
188synaptic vesicle exocytosis (GO:0016079)2.40931520
189positive regulation of neurotransmitter transport (GO:0051590)2.40783093
190positive regulation of response to nutrient levels (GO:0032109)2.39955667
191positive regulation of response to extracellular stimulus (GO:0032106)2.39955667
192dicarboxylic acid biosynthetic process (GO:0043650)2.37358321
193synaptonemal complex assembly (GO:0007130)2.36999711
194poly(A)+ mRNA export from nucleus (GO:0016973)12.8659706
195modulation by virus of host process (GO:0019054)10.3317023
196regulation of translational fidelity (GO:0006450)10.3040011

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.17821075
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.08602796
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.07273464
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.95333913
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.89776558
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.89776558
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.89776558
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.70323259
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.66918653
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.62648575
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56094170
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.38896144
13AR_21909140_ChIP-Seq_LNCAP_Human2.33745216
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.33189062
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.31954108
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23439388
17IGF1R_20145208_ChIP-Seq_DFB_Human2.23342943
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.23044619
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18343747
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.08908796
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.08852103
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.05860773
23GATA1_22025678_ChIP-Seq_K562_Human2.02516259
24E2F7_22180533_ChIP-Seq_HELA_Human11.0457269
25ZFP281_18757296_ChIP-ChIP_E14_Mouse1.98960266
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.98056447
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97874323
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.92404857
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91709109
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.88198049
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87843334
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.84598803
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.84340800
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82947367
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82860574
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81278380
37CDX2_22108803_ChIP-Seq_LS180_Human1.81074432
38SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.77050343
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72787111
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.70184352
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.70026030
42VDR_22108803_ChIP-Seq_LS180_Human1.69659859
43TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.68391538
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67521256
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65667154
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65630252
47CBP_20019798_ChIP-Seq_JUKART_Human1.65630252
48ELK1_19687146_ChIP-ChIP_HELA_Human1.64402272
49PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62587857
50NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.60819802
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.59482563
52TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.56420423
53EWS_26573619_Chip-Seq_HEK293_Human1.54326341
54NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.53444374
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50579005
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44998713
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42549639
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.42261805
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41405976
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.40930241
61* SALL4_22934838_ChIP-ChIP_CD34+_Human1.39211451
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39173130
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.37801457
64KDM2B_26808549_Chip-Seq_K562_Human1.37279098
65AR_21572438_ChIP-Seq_LNCaP_Human1.35879835
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.34844523
67P300_19829295_ChIP-Seq_ESCs_Human1.34256128
68MYC_22102868_ChIP-Seq_BL_Human1.34071697
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33206123
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30718549
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28407580
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28014626
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27852563
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27816422
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27648769
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27417716
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.26667066
78IRF1_19129219_ChIP-ChIP_H3396_Human1.26571928
79TCF4_23295773_ChIP-Seq_U87_Human1.26057419
80FUS_26573619_Chip-Seq_HEK293_Human1.25883166
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24903951
82ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24818348
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24043168
84E2F1_17053090_ChIP-ChIP_MCF-7_Human1.23333157
85TCF3_18692474_ChIP-Seq_MESCs_Mouse1.23312098
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23183968
87SMAD3_21741376_ChIP-Seq_HESCs_Human1.22969887
88TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.22755246
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.21739608
90TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21170480
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19904632
92OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18325410
93MYB_26560356_Chip-Seq_TH1_Human1.17811175
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16594727
95IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16237531
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.15879532
97TCF4_22108803_ChIP-Seq_LS180_Human1.15662059
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15211538
99POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14971503
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14238449
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.13813278
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13402287
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13402287
104SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13390657
105TCF7_22412390_ChIP-Seq_EML_Mouse1.12392485
106MYB_26560356_Chip-Seq_TH2_Human1.11681836
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10050501
108POU5F1_16518401_ChIP-PET_MESCs_Mouse1.09955510
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09946863
110FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09806261
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09793025
112RNF2_27304074_Chip-Seq_NSC_Mouse1.08734525
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08112412
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07669028
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.07658558
116TP53_16413492_ChIP-PET_HCT116_Human1.07571806
117EGR1_19374776_ChIP-ChIP_THP-1_Human1.07314465
118FOXO3_23340844_ChIP-Seq_DLD1_Human1.07223215
119RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07039868
120EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07039868
121ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06499713
122SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06438916
123GBX2_23144817_ChIP-Seq_PC3_Human1.06366190
124STAT3_23295773_ChIP-Seq_U87_Human1.06059237
125SOX2_21211035_ChIP-Seq_LN229_Gbm1.05538937
126* KDM2B_26808549_Chip-Seq_REH_Human1.04667817
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04604212
128PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02985281
129ZNF274_21170338_ChIP-Seq_K562_Hela1.02165576
130TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01952223
131RUNX_20019798_ChIP-Seq_JUKART_Human1.00882667
132CRX_20693478_ChIP-Seq_RETINA_Mouse1.00489074
133VDR_23849224_ChIP-Seq_CD4+_Human1.00162670
134PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00043741
135ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99945096
136NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99492783
137CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98879045
138STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98339512
139RING1B_27294783_Chip-Seq_NPCs_Mouse0.96485215
140KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96110871
141ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95805250
142CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95751833
143EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94884314
144THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94410675
145STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94151019
146NANOG_16153702_ChIP-ChIP_HESCs_Human0.93028716
147PIAS1_25552417_ChIP-Seq_VCAP_Human0.91855238
148BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91424101
149BRD4_25478319_ChIP-Seq_HGPS_Human0.91388592
150NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90511008
151SMC4_20622854_ChIP-Seq_HELA_Human0.90088298
152SMAD4_21799915_ChIP-Seq_A2780_Human0.89459398
153SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89316693
154NANOG_18555785_Chip-Seq_ESCs_Mouse0.88467110
155PRDM14_20953172_ChIP-Seq_ESCs_Human0.88216397
156P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87994580
157NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86640187
158SMAD3_21741376_ChIP-Seq_EPCs_Human0.85913069
159E2F1_21310950_ChIP-Seq_MCF-7_Human0.85783001
160NANOG_18692474_ChIP-Seq_MESCs_Mouse0.85659993
161CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85392811
162FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84112623
163RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84032250
164MYC_18555785_ChIP-Seq_MESCs_Mouse0.83538084
165ZNF263_19887448_ChIP-Seq_K562_Human0.83415125
166PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82577077
167FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82473955
168GATA6_25053715_ChIP-Seq_YYC3_Human0.82409151
169MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81420750
170MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.81396711
171EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81334496
172FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.81198764
173HNF4A_19822575_ChIP-Seq_HepG2_Human0.81106419
174TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80423027
175HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80237493
176FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80222516
177EOMES_21245162_ChIP-Seq_HESCs_Human0.79633442
178TAF15_26573619_Chip-Seq_HEK293_Human0.78742834
179TP53_20018659_ChIP-ChIP_R1E_Mouse0.78610867
180NANOG_16518401_ChIP-PET_MESCs_Mouse0.77991230
181KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76250757
182RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.75603897
183OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74242688
184LXR_22292898_ChIP-Seq_THP-1_Human0.74047068
185SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.74038648
186SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.73958042
187WT1_25993318_ChIP-Seq_PODOCYTE_Human0.73265524
188ELK3_25401928_ChIP-Seq_HUVEC_Human0.72909505
189POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.71945886
190TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.71386920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage9.77306925
2MP0002822_catalepsy7.56819428
3MP0008057_abnormal_DNA_replication4.15473884
4MP0003705_abnormal_hypodermis_morpholog3.87062883
5MP0001915_intracranial_hemorrhage3.46596131
6MP0001727_abnormal_embryo_implantation3.33058424
7MP0002139_abnormal_hepatobiliary_system3.19527129
8MP0002653_abnormal_ependyma_morphology3.18148345
9MP0000372_irregular_coat_pigmentation2.78841913
10MP0008877_abnormal_DNA_methylation2.73805581
11MP0002138_abnormal_hepatobiliary_system2.73640922
12MP0005360_urolithiasis2.64636884
13MP0004145_abnormal_muscle_electrophysio2.60934240
14MP0002837_dystrophic_cardiac_calcinosis2.56178232
15MP0004147_increased_porphyrin_level2.53134343
16MP0003890_abnormal_embryonic-extraembry2.52726239
17MP0004859_abnormal_synaptic_plasticity2.46949136
18MP0010352_gastrointestinal_tract_polyps2.38614189
19MP0005085_abnormal_gallbladder_physiolo2.29060422
20MP0003195_calcinosis2.27497591
21MP0005365_abnormal_bile_salt2.24412419
22MP0002254_reproductive_system_inflammat2.23470075
23MP0004264_abnormal_extraembryonic_tissu2.21708252
24MP0003787_abnormal_imprinting2.18263881
25MP0002089_abnormal_postnatal_growth/wei2.13842828
26MP0005171_absent_coat_pigmentation2.07107026
27MP0001849_ear_inflammation2.04408267
28MP0002332_abnormal_exercise_endurance1.87890157
29MP0002396_abnormal_hematopoietic_system1.82323965
30MP0004270_analgesia1.80065973
31MP0002090_abnormal_vision1.79437770
32MP0008961_abnormal_basal_metabolism1.74417072
33MP0004858_abnormal_nervous_system1.69643907
34MP0004808_abnormal_hematopoietic_stem1.60565903
35MP0005174_abnormal_tail_pigmentation1.60479741
36MP0008872_abnormal_physiological_respon1.59710840
37MP0000569_abnormal_digit_pigmentation1.58864253
38MP0001188_hyperpigmentation1.58769978
39MP0010329_abnormal_lipoprotein_level1.58539399
40MP0003567_abnormal_fetal_cardiomyocyte1.57827760
41MP0008058_abnormal_DNA_repair1.57416951
42MP0003121_genomic_imprinting1.57028022
43MP0005220_abnormal_exocrine_pancreas1.54204051
44MP0003656_abnormal_erythrocyte_physiolo1.50219470
45MP0003111_abnormal_nucleus_morphology1.47070067
46MP0010094_abnormal_chromosome_stability1.40842260
47MP0003693_abnormal_embryo_hatching1.40434534
48MP0004883_abnormal_blood_vessel1.38867697
49MP0000427_abnormal_hair_cycle1.38398488
50MP0003011_delayed_dark_adaptation1.38173513
51MP0009697_abnormal_copulation1.36384976
52MP0002909_abnormal_adrenal_gland1.34663042
53MP0003786_premature_aging1.34018242
54MP0003122_maternal_imprinting1.33709118
55MP0008875_abnormal_xenobiotic_pharmacok1.33244277
56MP0003635_abnormal_synaptic_transmissio1.32591887
57MP0002572_abnormal_emotion/affect_behav1.30469789
58MP0000647_abnormal_sebaceous_gland1.30139208
59MP0002734_abnormal_mechanical_nocicepti1.28453267
60MP0002064_seizures1.27913635
61MP0005257_abnormal_intraocular_pressure1.26948539
62MP0003436_decreased_susceptibility_to1.25353726
63MP0005394_taste/olfaction_phenotype1.23655049
64MP0005499_abnormal_olfactory_system1.23655049
65MP0002166_altered_tumor_susceptibility1.20968779
66MP0010307_abnormal_tumor_latency1.20101114
67MP0002877_abnormal_melanocyte_morpholog1.18241168
68MP0006138_congestive_heart_failure1.17466184
69MP0003935_abnormal_craniofacial_develop1.16970115
70MP0004381_abnormal_hair_follicle1.16699662
71MP0003252_abnormal_bile_duct1.16453357
72MP0003183_abnormal_peptide_metabolism1.14914986
73MP0002751_abnormal_autonomic_nervous1.14244042
74MP0001270_distended_abdomen1.14073969
75MP0000613_abnormal_salivary_gland1.13723729
76MP0006035_abnormal_mitochondrial_morpho1.12810612
77MP0004043_abnormal_pH_regulation1.11946264
78MP0003763_abnormal_thymus_physiology1.10717313
79MP0002092_abnormal_eye_morphology1.10498318
80MP0008995_early_reproductive_senescence1.10395961
81MP0002733_abnormal_thermal_nociception1.09976569
82MP0002063_abnormal_learning/memory/cond1.09307055
83MP0002006_tumorigenesis1.08508678
84MP0002086_abnormal_extraembryonic_tissu1.07805571
85MP0009745_abnormal_behavioral_response1.07729341
86MP0010030_abnormal_orbit_morphology1.07510545
87MP0006292_abnormal_olfactory_placode1.07035579
88MP0004134_abnormal_chest_morphology1.04277123
89MP0000049_abnormal_middle_ear1.04127868
90MP0005023_abnormal_wound_healing1.03696790
91MP0002269_muscular_atrophy1.03685247
92MP0001672_abnormal_embryogenesis/_devel1.03477769
93MP0005380_embryogenesis_phenotype1.03477769
94MP0005623_abnormal_meninges_morphology1.02341543
95MP0000609_abnormal_liver_physiology0.99315067
96MP0003632_abnormal_nervous_system0.97598835
97MP0000749_muscle_degeneration0.97222211
98MP0000467_abnormal_esophagus_morphology0.96823674
99MP0008932_abnormal_embryonic_tissue0.96782900
100MP0002127_abnormal_cardiovascular_syste0.96486694
101MP0001299_abnormal_eye_distance/0.95894582
102MP0000350_abnormal_cell_proliferation0.94665919
103MP0001970_abnormal_pain_threshold0.94400635
104MP0002075_abnormal_coat/hair_pigmentati0.92468734
105MP0000428_abnormal_craniofacial_morphol0.92287253
106MP0000432_abnormal_head_morphology0.91610388
107MP0000604_amyloidosis0.90450036
108MP0003091_abnormal_cell_migration0.86862842
109MP0001661_extended_life_span0.86817173
110MP0003806_abnormal_nucleotide_metabolis0.86486667
111MP0003123_paternal_imprinting0.86397906
112MP0002088_abnormal_embryonic_growth/wei0.85884634
113MP0003984_embryonic_growth_retardation0.85590166
114MP0005266_abnormal_metabolism0.85448980
115MP0005386_behavior/neurological_phenoty0.84910394
116MP0004924_abnormal_behavior0.84910394
117MP0001835_abnormal_antigen_presentation0.84187410
118MP0001851_eye_inflammation0.83448854
119MP0003943_abnormal_hepatobiliary_system0.83113993
120MP0008873_increased_physiological_sensi0.82318161
121MP0001905_abnormal_dopamine_level0.80720137
122MP0005409_darkened_coat_color0.79884298
123MP0003755_abnormal_palate_morphology0.79427882
124MP0008007_abnormal_cellular_replicative0.79416896
125MP0003950_abnormal_plasma_membrane0.79293933
126MP0004957_abnormal_blastocyst_morpholog0.78220103
127MP0002084_abnormal_developmental_patter0.78146046
128MP0003566_abnormal_cell_adhesion0.78035986
129MP0001286_abnormal_eye_development0.77576697
130MP0005646_abnormal_pituitary_gland0.77300916
131MP0005253_abnormal_eye_physiology0.76488000
132MP0010368_abnormal_lymphatic_system0.76391904
133MP0000689_abnormal_spleen_morphology0.76010381
134MP0002398_abnormal_bone_marrow0.75729080
135MP0003868_abnormal_feces_composition0.74863159
136MP0004185_abnormal_adipocyte_glucose0.74627697
137MP0001440_abnormal_grooming_behavior0.74615824
138MP0003045_fibrosis0.72561834
139MP0004811_abnormal_neuron_physiology0.72245310
140MP0005197_abnormal_uvea_morphology0.70812935
141MP0009046_muscle_twitch0.70466309
142MP0001486_abnormal_startle_reflex0.69881482
143MP0002085_abnormal_embryonic_tissue0.68620655
144MP0000751_myopathy0.68388154
145MP0002970_abnormal_white_adipose0.67697652
146MP0003861_abnormal_nervous_system0.66965905
147MP0000377_abnormal_hair_follicle0.66802630
148MP0000371_diluted_coat_color0.66411715
149MP0005075_abnormal_melanosome_morpholog0.66223274
150MP0001340_abnormal_eyelid_morphology0.65970018
151MP0005671_abnormal_response_to0.65654842
152MP0000639_abnormal_adrenal_gland0.65264303
153MP0009703_decreased_birth_body0.64556725
154MP0004130_abnormal_muscle_cell0.64519536
155MP0004197_abnormal_fetal_growth/weight/0.63406710
156MP0000778_abnormal_nervous_system0.63168363
157MP0000516_abnormal_urinary_system0.62694289
158MP0005367_renal/urinary_system_phenotyp0.62694289
159MP0001119_abnormal_female_reproductive0.61906677
160MP0001730_embryonic_growth_arrest0.61872032
161MP0008770_decreased_survivor_rate0.61467202
162MP0005076_abnormal_cell_differentiation0.60525355
163MP0000750_abnormal_muscle_regeneration0.60181568
164MP0003329_amyloid_beta_deposits0.59970215
165MP0003077_abnormal_cell_cycle0.59585897
166MP0005595_abnormal_vascular_smooth0.58860578
167MP0002938_white_spotting0.58464458
168MP0002722_abnormal_immune_system0.58160486
169MP0004742_abnormal_vestibular_system0.57307903
170MP0002111_abnormal_tail_morphology0.56725610
171MP0002160_abnormal_reproductive_system0.56358845
172MP0000920_abnormal_myelination0.55939833
173MP0002184_abnormal_innervation0.52671883
174MP0002080_prenatal_lethality0.52085559
175MP0002108_abnormal_muscle_morphology0.51920701
176MP0001186_pigmentation_phenotype0.51871870
177MP0001697_abnormal_embryo_size0.51146027
178MP0000703_abnormal_thymus_morphology0.51004533
179MP0002102_abnormal_ear_morphology0.50321724

Predicted human phenotypes

RankGene SetZ-score
1Disinhibition (HP:0000734)8.08607611
2Axonal loss (HP:0003447)5.86124514
3Inappropriate behavior (HP:0000719)5.48077857
4Personality changes (HP:0000751)5.46940497
5Mask-like facies (HP:0000298)5.42985862
6Neck muscle weakness (HP:0000467)4.63045767
7Hypochromic microcytic anemia (HP:0004840)4.60422978
8Abnormality of the lower motor neuron (HP:0002366)4.35899601
9Neonatal hypoglycemia (HP:0001998)4.00807717
10Hyperventilation (HP:0002883)3.90642170
11Amblyopia (HP:0000646)3.83961948
12Intrahepatic cholestasis (HP:0001406)3.83317265
13Bile duct proliferation (HP:0001408)3.68211618
14Abnormal biliary tract physiology (HP:0012439)3.68211618
15Recurrent bacterial skin infections (HP:0005406)3.67696409
16Sensory axonal neuropathy (HP:0003390)3.65554143
17Amelogenesis imperfecta (HP:0000705)3.57375972
18Deep venous thrombosis (HP:0002625)3.44917487
19Hepatoblastoma (HP:0002884)3.34518182
20Bilateral microphthalmos (HP:0007633)3.24468010
21Abnormality of the labia minora (HP:0012880)3.13285070
22Recurrent abscess formation (HP:0002722)2.93462982
23Neurofibrillary tangles (HP:0002185)2.88622794
24Ependymoma (HP:0002888)2.84349447
25Abnormal gallbladder physiology (HP:0012438)2.82369899
26Cholecystitis (HP:0001082)2.82369899
27Abnormal sex determination (HP:0012244)2.79264743
28Sex reversal (HP:0012245)2.79264743
29Orthostatic hypotension (HP:0001278)2.73174521
30Myokymia (HP:0002411)2.72295327
31Lower limb hyperreflexia (HP:0002395)2.70114352
32Epileptic encephalopathy (HP:0200134)2.66140378
33Generalized hypotonia (HP:0001290)2.64990754
34Hypoalphalipoproteinemia (HP:0003233)2.64637011
35Impulsivity (HP:0100710)2.64309194
36Hypothermia (HP:0002045)2.63330953
37Rhabdomyosarcoma (HP:0002859)2.62185223
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.61992826
39Pathologic fracture (HP:0002756)2.54909836
40External ophthalmoplegia (HP:0000544)2.53948586
41Aqueductal stenosis (HP:0002410)2.51834673
42Absent radius (HP:0003974)2.46315237
43Short chin (HP:0000331)2.44595561
44Cholelithiasis (HP:0001081)2.44187805
45Skin nodule (HP:0200036)2.43986048
46Cortical dysplasia (HP:0002539)2.40323779
47Shawl scrotum (HP:0000049)2.39575288
48Abnormality of the astrocytes (HP:0100707)2.35274089
49Astrocytoma (HP:0009592)2.35274089
50Horizontal nystagmus (HP:0000666)2.33676101
51Encephalitis (HP:0002383)2.33224924
52Abnormality of chromosome stability (HP:0003220)2.32516308
53Multiple enchondromatosis (HP:0005701)2.32104654
54Abnormal gallbladder morphology (HP:0012437)2.30048578
55Birth length less than 3rd percentile (HP:0003561)2.29574293
56Basal ganglia calcification (HP:0002135)2.29247835
57Wrist flexion contracture (HP:0001239)2.28231045
58Neoplasm of striated muscle (HP:0009728)2.27277008
59Attenuation of retinal blood vessels (HP:0007843)2.25515235
60Absent forearm bone (HP:0003953)2.25175559
61Aplasia involving forearm bones (HP:0009822)2.25175559
62T lymphocytopenia (HP:0005403)2.24662563
63Ketosis (HP:0001946)2.24282869
64Atonic seizures (HP:0010819)2.24039525
65Spinal muscular atrophy (HP:0007269)2.22342823
66Abnormality of the salivary glands (HP:0010286)2.18912827
67Acanthocytosis (HP:0001927)2.18100365
68Upper motor neuron abnormality (HP:0002127)2.16492630
69EMG: neuropathic changes (HP:0003445)2.15936197
70Status epilepticus (HP:0002133)2.15640154
71Rib fusion (HP:0000902)2.14786073
72Abnormal neuron morphology (HP:0012757)2.14155453
73Abnormality of the motor neurons (HP:0002450)2.14155453
74Hyperinsulinemic hypoglycemia (HP:0000825)2.12990274
75Abnormal cartilage morphology (HP:0002763)2.12205246
76Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12150464
77Bone cyst (HP:0012062)2.11115343
78Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11111550
79Abnormality of the nasal septum (HP:0000419)2.09436910
80Xanthomatosis (HP:0000991)2.09301339
81Dysmetric saccades (HP:0000641)2.08497895
82Facial cleft (HP:0002006)2.06825223
83Panhypogammaglobulinemia (HP:0003139)2.06008275
84Bifid tongue (HP:0010297)2.05292610
85Resting tremor (HP:0002322)2.03553642
86Hypolipoproteinemia (HP:0010981)2.02996693
87Acute hepatic failure (HP:0006554)2.02062564
88Overlapping toe (HP:0001845)2.01548658
89Agnosia (HP:0010524)13.1120335
90Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)11.4110927
91Cerebral inclusion bodies (HP:0100314)1.99687132
92Heterotopia (HP:0002282)1.99092875
93Abnormality of the corticospinal tract (HP:0002492)1.98647528
94Intestinal fistula (HP:0100819)1.94273415
95Abnormal autonomic nervous system physiology (HP:0012332)1.94187518
96Chromsome breakage (HP:0040012)1.94001439
97Tetraplegia (HP:0002445)1.92778473
98Hypobetalipoproteinemia (HP:0003563)1.92413263
99Abnormality of T cell number (HP:0011839)1.91620955
100Shallow orbits (HP:0000586)1.91196797
101Fused cervical vertebrae (HP:0002949)1.90801688
102Ragged-red muscle fibers (HP:0003200)1.90754803
103Hepatocellular carcinoma (HP:0001402)1.90694913
104Abnormal social behavior (HP:0012433)1.90620773
105Impaired social interactions (HP:0000735)1.90620773
106Recurrent skin infections (HP:0001581)1.89284637
107Pseudobulbar signs (HP:0002200)1.88559363
108Abnormality of the fingertips (HP:0001211)1.87208559
109Spontaneous hematomas (HP:0007420)1.85726846
110Atrophic scars (HP:0001075)1.84613618
111Abnormality of monocarboxylic acid metabolism (HP:0010996)1.84547834
112Obstructive sleep apnea (HP:0002870)1.83967049
113Preaxial foot polydactyly (HP:0001841)1.83763299
114Excessive salivation (HP:0003781)1.83579144
115Drooling (HP:0002307)1.83579144
116Aplasia/Hypoplasia of the sternum (HP:0006714)1.83437991
117Rectal fistula (HP:0100590)1.82051033
118Rectovaginal fistula (HP:0000143)1.82051033
119Absent thumb (HP:0009777)1.80936823
120Abnormality of methionine metabolism (HP:0010901)1.80009675
121Spondylolisthesis (HP:0003302)1.79643182
122Exotropia (HP:0000577)1.79063624
123Pendular nystagmus (HP:0012043)1.79027180
124Turricephaly (HP:0000262)1.76862621
125Cleft eyelid (HP:0000625)1.76682894
126Oculomotor apraxia (HP:0000657)1.76087789
127Aplasia/Hypoplasia of the uvula (HP:0010293)1.72641638
128Clubbing of toes (HP:0100760)1.71949247
129Poor eye contact (HP:0000817)1.71634670
130Colitis (HP:0002583)1.71236299
131Choanal stenosis (HP:0000452)1.71160887
132CNS hypomyelination (HP:0003429)1.70935432
133Abnormality of chromosome segregation (HP:0002916)1.70699135
134Cellular immunodeficiency (HP:0005374)1.69029169
135Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68994474
136Amyotrophic lateral sclerosis (HP:0007354)1.68986332
137Abnormality of the preputium (HP:0100587)1.68491357
138Large earlobe (HP:0009748)1.68268847
139Open mouth (HP:0000194)1.68012651
140Meckel diverticulum (HP:0002245)1.66164127
141Chronic hepatic failure (HP:0100626)1.65170127
1422-3 toe syndactyly (HP:0004691)1.64667219
143Abnormality of the ileum (HP:0001549)1.64442155
144Premature skin wrinkling (HP:0100678)1.64360897
145Polyphagia (HP:0002591)1.64344281
146Abnormality of sulfur amino acid metabolism (HP:0004339)1.64208960
147Acute myeloid leukemia (HP:0004808)1.63400478
148Increased connective tissue (HP:0009025)1.63207023
149Renal cortical cysts (HP:0000803)1.63011172
150Glossoptosis (HP:0000162)1.62916815
151Hand muscle atrophy (HP:0009130)1.62813131
152Short humerus (HP:0005792)1.62523140
153Impaired platelet aggregation (HP:0003540)1.61094468
154Abnormal platelet function (HP:0011869)1.61094468
155Vaginal fistula (HP:0004320)1.60963106
156Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.60773034
157Diminished motivation (HP:0000745)1.60767096
158Absent frontal sinuses (HP:0002688)1.60269279
159Aplasia/hypoplasia of the humerus (HP:0006507)1.58734071
160Progressive external ophthalmoplegia (HP:0000590)1.58682010
161Distal upper limb amyotrophy (HP:0007149)1.58648475
162Upper limb amyotrophy (HP:0009129)1.58648475
163Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.57295173
164Gastrointestinal infarctions (HP:0005244)1.56796558
165Abnormality of the columella (HP:0009929)1.56783835
166Poikiloderma (HP:0001029)1.56437701
167Hypophosphatemic rickets (HP:0004912)1.55599653
168Nephroblastoma (Wilms tumor) (HP:0002667)1.54488411
169Spastic paraparesis (HP:0002313)1.52348679
170Adactyly (HP:0009776)1.50660172
171Poor head control (HP:0002421)1.49726303
172Abnormality of the parathyroid morphology (HP:0011766)1.47957688
173Abnormality of the proximal phalanges of the hand (HP:0009834)1.46528681
174Myelodysplasia (HP:0002863)1.46416437
175Trismus (HP:0000211)1.45167942
176Spastic tetraparesis (HP:0001285)1.43827782
177Embryonal renal neoplasm (HP:0011794)1.43510249
178Squamous cell carcinoma (HP:0002860)1.42336431
179Underdeveloped nasal alae (HP:0000430)1.41018256
180Increased number of teeth (HP:0011069)1.40152021
181Conjunctival telangiectasia (HP:0000524)1.39767034
182Recurrent viral infections (HP:0004429)1.38230900
183Neoplasm of the small intestine (HP:0100833)1.38056889
184Abnormality of the phalanges of the 5th finger (HP:0004213)1.37902388

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK16.93544616
2SCYL25.52556054
3CASK5.32579463
4GRK53.95757840
5CDK123.77201878
6MOS3.72769529
7CDC73.60452364
8ERN13.16091998
9GRK62.99056267
10DAPK22.93293458
11FRK2.80661542
12MKNK22.46732643
13NLK2.42013713
14TRIB32.40182115
15BRSK22.35425177
16NEK12.10353964
17DYRK1A2.04945307
18NEK21.95830554
19DAPK11.95608236
20BMPR1B1.90362089
21BMPR21.89277295
22SIK11.86549252
23STK101.81982681
24NUAK11.81427273
25GRK71.73675847
26ACVR1B1.73209837
27NTRK11.69197884
28TYRO31.62351093
29TSSK61.59114854
30MAP2K41.57287238
31EIF2AK31.55823402
32RPS6KB21.54045263
33EPHA41.54003334
34MKNK11.52937045
35ZAK1.51483386
36TRPM71.51319083
37CDK191.51002980
38TTK1.47932541
39AKT31.47557091
40MAPK71.45400667
41MST41.41138478
42SYK1.37389262
43MAP3K91.32416485
44SRPK11.31300019
45RIPK11.30335517
46MAP3K71.28988428
47CSF1R1.23782711
48TAOK31.20500423
49TEC1.18621204
50TRIM281.17849973
51TGFBR21.17085034
52MARK21.16855396
53FLT31.14757669
54UHMK11.14655085
55PLK41.14157583
56SIK21.12165405
57MAP3K101.11765600
58BCKDK1.11098983
59LATS21.10656598
60STK391.09876328
61WEE11.07088790
62NTRK31.06876550
63CSNK1G11.03184999
64TNIK1.02755550
65WNK41.00121047
66CCNB10.99972493
67ADRBK10.99885174
68KIT0.99026943
69CAMK40.98550071
70MATK0.93226118
71PLK20.90686392
72PLK30.90046762
73CSNK1A1L0.89671140
74ADRBK20.88268842
75PDK20.85134248
76FGFR20.84263104
77CDK150.83888814
78GRK10.83095949
79CDK180.78891890
80BRD40.76712414
81ATR0.76183334
82SGK20.75330596
83PAK60.74876903
84PKN20.74527892
85ERBB40.73926035
86FGFR30.72330468
87LCK0.71128462
88MELK0.70778768
89MAP3K80.70170220
90PAK40.69476528
91PLK10.67189358
92STK160.67095641
93SGK30.66178386
94CDK11A0.65825331
95BRSK10.63334037
96ATM0.63179574
97MAP3K40.63048052
98CDK80.62834295
99DYRK20.61913090
100CDK140.60638281
101NEK90.60502928
102CSNK1D0.60339482
103LATS10.58593969
104MAP3K30.58450212
105ITK0.58163174
106TTN0.57518359
107MAP3K10.56130203
108MARK30.51908985
109MAPK40.51137457
110CSNK1G30.49016787
111EEF2K0.47474778
112CHEK20.45634418
113PRKAA20.44566835
114WNK10.44526869
115PDGFRA0.43862359
116CHEK10.43783965
117CDK40.43765500
118MAP3K120.43596862
119PAK10.43333315
120CDK50.42700937
121IGF1R0.41758951
122NTRK20.40705306
123MAPK110.39830771
124PIK3CG0.39696341
125CDK70.38470079
126MAP2K60.37461537
127MAPK100.37150151
128PTK20.36481530
129PRKDC0.35772341
130ROCK20.35626900
131SGK2230.35139400
132SGK4940.35139400
133PRKCQ0.34573639
134TESK20.34283805
135DDR20.34268311
136OBSCN0.34195518
137MARK10.33918770
138BUB10.33742613
139TGFBR10.33230082
140AURKA0.33178406
141BTK0.32527191
142BLK0.31902916
143PRKCI0.31407871
144CDK20.30682070
145CSNK1E0.29921804
146STK30.29825124
147FGFR10.29550003
148MAPKAPK50.29495963
149MAPK120.29051048
150AURKB0.29038727
151PHKG10.28874456
152PHKG20.28874456
153EPHA20.28671933
154MAP2K10.28645063
155BCR0.27991908
156CAMK1D0.27490924
157MAP3K130.27456430
158PRKCH0.26633750
159PTK2B0.26553738
160IRAK40.26319481
161RPS6KA40.26194622
162DAPK30.25571961
163TAF10.24468265
164CSNK1G20.24162997
165EIF2AK20.24021618
166STK380.23825921
167CSNK2A20.23720155
168KSR20.22964190
169RPS6KA30.22148896
170PRKACB0.20714090
171OXSR10.20395489

Predicted pathways (KEGG)

RankGene SetZ-score
1mRNA surveillance pathway_Homo sapiens_hsa030153.86850429
2Sulfur relay system_Homo sapiens_hsa041223.28842156
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.27398476
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.27213833
5Ether lipid metabolism_Homo sapiens_hsa005653.25714983
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.21046311
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.64633293
8Vitamin B6 metabolism_Homo sapiens_hsa007502.55918479
9Tryptophan metabolism_Homo sapiens_hsa003802.36377367
10RNA transport_Homo sapiens_hsa030132.32238308
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.30664940
12Non-homologous end-joining_Homo sapiens_hsa034502.28066761
13RNA polymerase_Homo sapiens_hsa030202.27655299
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27285862
15Arginine biosynthesis_Homo sapiens_hsa002202.11537819
16Tyrosine metabolism_Homo sapiens_hsa003502.08216024
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.01798346
18Butanoate metabolism_Homo sapiens_hsa006502.00641406
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00213667
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98271859
21Synaptic vesicle cycle_Homo sapiens_hsa047211.87005992
22Fatty acid degradation_Homo sapiens_hsa000711.85322397
23Fatty acid metabolism_Homo sapiens_hsa012121.82964739
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.82255021
25Fanconi anemia pathway_Homo sapiens_hsa034601.81152430
26Arachidonic acid metabolism_Homo sapiens_hsa005901.79448860
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72188049
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70481266
29Bile secretion_Homo sapiens_hsa049761.67677064
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.66936283
31Complement and coagulation cascades_Homo sapiens_hsa046101.65900468
32Pyruvate metabolism_Homo sapiens_hsa006201.63983707
33Nitrogen metabolism_Homo sapiens_hsa009101.55060920
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50036896
35DNA replication_Homo sapiens_hsa030301.44877982
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41235475
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.39750505
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27146989
39Biosynthesis of amino acids_Homo sapiens_hsa012301.25344730
40PPAR signaling pathway_Homo sapiens_hsa033201.23718553
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.22667562
42Cell cycle_Homo sapiens_hsa041101.20952459
43Carbon metabolism_Homo sapiens_hsa012001.16432797
44Thyroid cancer_Homo sapiens_hsa052161.15290921
45Ovarian steroidogenesis_Homo sapiens_hsa049131.13449429
46RNA degradation_Homo sapiens_hsa030181.13206050
47Collecting duct acid secretion_Homo sapiens_hsa049661.11092466
48Viral myocarditis_Homo sapiens_hsa054161.09594298
49GnRH signaling pathway_Homo sapiens_hsa049121.08233926
50Long-term depression_Homo sapiens_hsa047301.08137538
51p53 signaling pathway_Homo sapiens_hsa041151.07652905
52One carbon pool by folate_Homo sapiens_hsa006701.06534603
53Oocyte meiosis_Homo sapiens_hsa041141.04235240
54Phenylalanine metabolism_Homo sapiens_hsa003601.02226721
55Homologous recombination_Homo sapiens_hsa034401.02133062
56Prostate cancer_Homo sapiens_hsa052150.98461105
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95407763
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94274010
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93728258
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92069246
61Propanoate metabolism_Homo sapiens_hsa006400.91800433
62Folate biosynthesis_Homo sapiens_hsa007900.91477629
63Dorso-ventral axis formation_Homo sapiens_hsa043200.91473570
64TGF-beta signaling pathway_Homo sapiens_hsa043500.91236246
65Base excision repair_Homo sapiens_hsa034100.90483675
66Lysine degradation_Homo sapiens_hsa003100.86167468
67Systemic lupus erythematosus_Homo sapiens_hsa053220.83892574
68Long-term potentiation_Homo sapiens_hsa047200.82589502
69Influenza A_Homo sapiens_hsa051640.82115811
70Colorectal cancer_Homo sapiens_hsa052100.81790783
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.79853200
72Glucagon signaling pathway_Homo sapiens_hsa049220.79853147
73ABC transporters_Homo sapiens_hsa020100.78230469
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77992993
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77452656
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76397235
77Dopaminergic synapse_Homo sapiens_hsa047280.74644161
78Fructose and mannose metabolism_Homo sapiens_hsa000510.72230957
79Peroxisome_Homo sapiens_hsa041460.72167165
80Epstein-Barr virus infection_Homo sapiens_hsa051690.71537639
81Fatty acid elongation_Homo sapiens_hsa000620.71267161
82Pyrimidine metabolism_Homo sapiens_hsa002400.70544150
83Mismatch repair_Homo sapiens_hsa034300.70304341
84Pancreatic cancer_Homo sapiens_hsa052120.69698456
85Insulin secretion_Homo sapiens_hsa049110.69381783
86Linoleic acid metabolism_Homo sapiens_hsa005910.69327808
87Graft-versus-host disease_Homo sapiens_hsa053320.67719818
88Melanoma_Homo sapiens_hsa052180.66167788
89Autoimmune thyroid disease_Homo sapiens_hsa053200.66160974
90Serotonergic synapse_Homo sapiens_hsa047260.66053015
91Proteasome_Homo sapiens_hsa030500.65700692
92Nucleotide excision repair_Homo sapiens_hsa034200.65004388
93Histidine metabolism_Homo sapiens_hsa003400.64547277
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64259374
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64119744
96Glutamatergic synapse_Homo sapiens_hsa047240.62161332
97Glioma_Homo sapiens_hsa052140.61016072
98Purine metabolism_Homo sapiens_hsa002300.60832810
99Chemical carcinogenesis_Homo sapiens_hsa052040.58751311
100Vibrio cholerae infection_Homo sapiens_hsa051100.58703047
101Amphetamine addiction_Homo sapiens_hsa050310.58440197
102Allograft rejection_Homo sapiens_hsa053300.58137427
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58081207
104mTOR signaling pathway_Homo sapiens_hsa041500.57759835
105MicroRNAs in cancer_Homo sapiens_hsa052060.54996136
106Gap junction_Homo sapiens_hsa045400.53413865
107Inositol phosphate metabolism_Homo sapiens_hsa005620.53112691
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52076250
109Steroid biosynthesis_Homo sapiens_hsa001000.50606938
110Wnt signaling pathway_Homo sapiens_hsa043100.49956038
111Viral carcinogenesis_Homo sapiens_hsa052030.49467783
112Alcoholism_Homo sapiens_hsa050340.48796469
113GABAergic synapse_Homo sapiens_hsa047270.48143150
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47136499
115Non-small cell lung cancer_Homo sapiens_hsa052230.46034798
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44873312
117Fatty acid biosynthesis_Homo sapiens_hsa000610.44078352
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44005520
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.43879095
120Bladder cancer_Homo sapiens_hsa052190.43295921
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43255238
122Insulin resistance_Homo sapiens_hsa049310.41862342
123Taste transduction_Homo sapiens_hsa047420.41690988
124Rap1 signaling pathway_Homo sapiens_hsa040150.41294182
125Circadian rhythm_Homo sapiens_hsa047100.40647365
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40589656
127Adherens junction_Homo sapiens_hsa045200.40505919
128Insulin signaling pathway_Homo sapiens_hsa049100.40359201
129Choline metabolism in cancer_Homo sapiens_hsa052310.40084836
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40070166
131Salivary secretion_Homo sapiens_hsa049700.37298374
132Cholinergic synapse_Homo sapiens_hsa047250.36830218
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36769353
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.36210641
135ErbB signaling pathway_Homo sapiens_hsa040120.35818937
136Small cell lung cancer_Homo sapiens_hsa052220.35187616
137beta-Alanine metabolism_Homo sapiens_hsa004100.34983008
138Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34811480
139Ras signaling pathway_Homo sapiens_hsa040140.33742339
140Selenocompound metabolism_Homo sapiens_hsa004500.33574169
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33213082
142cAMP signaling pathway_Homo sapiens_hsa040240.33126416
143Hematopoietic cell lineage_Homo sapiens_hsa046400.32857316
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.32409758
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31924451
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.31861901
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31813176
148Herpes simplex infection_Homo sapiens_hsa051680.31633639
149Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30969200
150Calcium signaling pathway_Homo sapiens_hsa040200.30799169
151Staphylococcus aureus infection_Homo sapiens_hsa051500.30399835
152Fat digestion and absorption_Homo sapiens_hsa049750.29921739
153Basal transcription factors_Homo sapiens_hsa030220.29916871
154FoxO signaling pathway_Homo sapiens_hsa040680.28463481
155Measles_Homo sapiens_hsa051620.24083735
156Type I diabetes mellitus_Homo sapiens_hsa049400.24014577
157Phototransduction_Homo sapiens_hsa047440.23803330
158Chronic myeloid leukemia_Homo sapiens_hsa052200.23133427
159Hepatitis B_Homo sapiens_hsa051610.20425318
160Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20248540
161Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20074956
162Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19186756
163Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17606763
164Glutathione metabolism_Homo sapiens_hsa004800.15509181
165Primary immunodeficiency_Homo sapiens_hsa053400.14686003
166Legionellosis_Homo sapiens_hsa051340.14266141
167Vitamin digestion and absorption_Homo sapiens_hsa049770.13932897
168Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.12813020
169Regulation of autophagy_Homo sapiens_hsa041400.12783576

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