CLDN24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is 75% identical to the mouse homolog. This gene is upstream of the CLDN22 gene, which overlaps the WWC2 gene on the opposite strand in the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenol-containing compound catabolic process (GO:0019336)7.28980280
2sympathetic nervous system development (GO:0048485)5.92906611
3neurotransmitter catabolic process (GO:0042135)5.57096097
4cell migration in hindbrain (GO:0021535)5.49495992
5neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)5.44309894
6viral transcription (GO:0019083)5.11230328
7ganglion development (GO:0061548)5.09867003
8translational termination (GO:0006415)4.87523103
9response to water (GO:0009415)4.82911822
10enteric nervous system development (GO:0048484)4.71857218
11catecholamine transport (GO:0051937)4.34440845
12facial nerve structural organization (GO:0021612)4.28576043
13axon extension involved in axon guidance (GO:0048846)4.25541698
14neuron projection extension involved in neuron projection guidance (GO:1902284)4.25541698
15neuron remodeling (GO:0016322)4.16207559
16ribosomal small subunit biogenesis (GO:0042274)4.11537203
17regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.09380215
18negative regulation of histone acetylation (GO:0035067)4.09126165
19nephron tubule formation (GO:0072079)3.97109121
20nerve growth factor signaling pathway (GO:0038180)3.96349901
21translational elongation (GO:0006414)3.88687424
22positive regulation of synapse assembly (GO:0051965)3.80015674
23protein targeting to ER (GO:0045047)3.79864774
24cotranslational protein targeting to membrane (GO:0006613)3.79474962
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.79362095
26viral life cycle (GO:0019058)3.74742708
27cellular protein complex disassembly (GO:0043624)3.69832704
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.65415129
29protein localization to endoplasmic reticulum (GO:0070972)3.64440705
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.58934767
31proline transport (GO:0015824)3.58116108
32cellular response to nicotine (GO:0071316)3.56139495
33import into cell (GO:0098657)3.51773362
34atrial cardiac muscle cell action potential (GO:0086014)3.50677140
35cranial nerve morphogenesis (GO:0021602)3.45218255
36neurotransmitter biosynthetic process (GO:0042136)3.44498375
37negative regulation of dendrite morphogenesis (GO:0050774)3.42735419
38cranial nerve structural organization (GO:0021604)3.35525057
39semaphorin-plexin signaling pathway (GO:0071526)3.27754798
40negative regulation of microtubule polymerization (GO:0031115)3.25241479
41glycine transport (GO:0015816)3.24735452
42coenzyme catabolic process (GO:0009109)3.24536335
43cornea development in camera-type eye (GO:0061303)3.24162087
44protein complex disassembly (GO:0043241)3.23846893
45ventricular system development (GO:0021591)3.23819328
46positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.20306729
47negative regulation of peptidyl-lysine acetylation (GO:2000757)3.19940893
48behavioral response to nicotine (GO:0035095)3.19626778
49regulation of axon extension involved in axon guidance (GO:0048841)3.15353740
50dopamine metabolic process (GO:0042417)3.13923816
51striatum development (GO:0021756)3.12976331
52calcium-mediated signaling using intracellular calcium source (GO:0035584)3.11795851
53cellular response to leptin stimulus (GO:0044320)3.09275582
54negative regulation of T-helper cell differentiation (GO:0045623)3.08544770
55negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.08544770
56macromolecular complex disassembly (GO:0032984)3.06609842
57neuron maturation (GO:0042551)3.02409278
58regulation of neuron projection regeneration (GO:0070570)3.02398867
59regulation of axon regeneration (GO:0048679)3.02398867
60translational initiation (GO:0006413)2.98487025
61negative regulation of macrophage differentiation (GO:0045650)2.98224676
62synaptic vesicle maturation (GO:0016188)2.95522620
63regulation of respiratory system process (GO:0044065)2.92838256
64response to laminar fluid shear stress (GO:0034616)2.92596379
65detection of temperature stimulus (GO:0016048)2.89508087
66cellular response to nerve growth factor stimulus (GO:1990090)2.87432056
67response to nerve growth factor (GO:1990089)2.87432056
68synaptic vesicle exocytosis (GO:0016079)2.86311191
69regulation of respiratory gaseous exchange (GO:0043576)2.86009773
70detection of temperature stimulus involved in sensory perception (GO:0050961)2.85239975
71detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.85239975
72collecting duct development (GO:0072044)2.85067910
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.82286460
74negative regulation of protein acetylation (GO:1901984)2.81223636
75ribosomal small subunit assembly (GO:0000028)2.79913470
76negative regulation of axon extension involved in axon guidance (GO:0048843)2.78281099
77regulation of axon guidance (GO:1902667)2.77939196
78nucleobase catabolic process (GO:0046113)2.77491261
79establishment of tissue polarity (GO:0007164)2.77366981
80establishment of planar polarity (GO:0001736)2.77366981
81negative regulation of histone methylation (GO:0031061)2.77193113
82dopaminergic neuron differentiation (GO:0071542)2.75175410
83daunorubicin metabolic process (GO:0044597)2.71096821
84polyketide metabolic process (GO:0030638)2.71096821
85doxorubicin metabolic process (GO:0044598)2.71096821
86neurotransmitter metabolic process (GO:0042133)2.68040297
87detection of mechanical stimulus involved in sensory perception (GO:0050974)2.67221185
88cell adhesion mediated by integrin (GO:0033627)2.67025297
89locomotory exploration behavior (GO:0035641)2.62606770
90protein targeting to membrane (GO:0006612)2.61185899
91L-phenylalanine metabolic process (GO:0006558)2.60841020
92erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.60841020
93cAMP-mediated signaling (GO:0019933)2.58896877
94DNA damage induced protein phosphorylation (GO:0006975)2.58809731
95positive regulation of fibroblast migration (GO:0010763)2.56963372
96regulation of synapse assembly (GO:0051963)2.55996080
97erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.55813974
98L-phenylalanine catabolic process (GO:0006559)2.55813974
99negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.52624751
100cerebellar Purkinje cell differentiation (GO:0021702)2.52397802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.67797432
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.50767199
3EZH2_22144423_ChIP-Seq_EOC_Human3.16567368
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99243362
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95506165
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.92598507
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.83521642
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.81640380
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80121871
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80121871
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70257821
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.69625714
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.59585607
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55669594
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.47795773
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.44480602
17ERG_21242973_ChIP-ChIP_JURKAT_Human2.43106684
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39434820
19CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.32254098
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26322902
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.26155849
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.23405907
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22323890
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16291682
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16267420
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14238869
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.11934314
28TP53_20018659_ChIP-ChIP_R1E_Mouse2.02219312
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01880628
30NR3C1_23031785_ChIP-Seq_PC12_Mouse2.00254519
31ZNF263_19887448_ChIP-Seq_K562_Human1.97183535
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.90322349
33DROSHA_22980978_ChIP-Seq_HELA_Human1.86442939
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.86203319
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79967413
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75904889
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.72641604
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.71534134
39RING1B_27294783_Chip-Seq_NPCs_Mouse1.66718197
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66059107
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.54775549
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.54006869
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53029619
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.51373993
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.48763941
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44772632
47GBX2_23144817_ChIP-Seq_PC3_Human1.43605404
48EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37176736
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.36391927
50REST_21632747_ChIP-Seq_MESCs_Mouse1.34837582
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34213310
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27549177
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16858579
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14516251
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13367159
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12538439
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09777652
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09475527
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03613234
60RNF2_27304074_Chip-Seq_NSC_Mouse1.03372067
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01436696
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99833872
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97061526
64EOMES_21245162_ChIP-Seq_HESCs_Human0.96497423
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96474351
66KDM2B_26808549_Chip-Seq_K562_Human0.96077744
67AR_21572438_ChIP-Seq_LNCaP_Human0.92670838
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92061840
69SOX2_20726797_ChIP-Seq_SW620_Human0.91566887
70ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91485435
71SMAD4_21741376_ChIP-Seq_HESCs_Human0.89594339
72CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89472188
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89166730
74HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88648757
75SMAD3_21741376_ChIP-Seq_EPCs_Human0.87504669
76RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86828368
77OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86732994
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84724822
79AR_21909140_ChIP-Seq_LNCAP_Human0.83109779
80CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82417477
81STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.82354774
82CTCF_27219007_Chip-Seq_Bcells_Human0.82078456
83REST_18959480_ChIP-ChIP_MESCs_Mouse0.81124942
84SMAD4_21799915_ChIP-Seq_A2780_Human0.81092105
85TCF4_18268006_ChIP-ChIP_LS174T_Human0.80625038
86ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80196676
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78835092
88AR_25329375_ChIP-Seq_VCAP_Human0.76333817
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.75182090
90VDR_24787735_ChIP-Seq_THP-1_Human0.74411117
91JUN_21703547_ChIP-Seq_K562_Human0.74047921
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.73412827
93FOXM1_26456572_ChIP-Seq_MCF-7_Human0.72927197
94SMAD_19615063_ChIP-ChIP_OVARY_Human0.72494782
95MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.72385436
96PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72154036
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.70610493
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69891965
99IKZF1_21737484_ChIP-ChIP_HCT116_Human0.68629758
100SCL_19346495_ChIP-Seq_HPC-7_Human0.68289295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy3.79507496
2MP0005377_hearing/vestibular/ear_phenot3.57276539
3MP0003878_abnormal_ear_physiology3.57276539
4MP0003879_abnormal_hair_cell3.29856390
5MP0009379_abnormal_foot_pigmentation3.21797918
6MP0001485_abnormal_pinna_reflex3.11113529
7MP0002102_abnormal_ear_morphology2.83820915
8MP0005083_abnormal_biliary_tract2.75123330
9MP0001529_abnormal_vocalization2.74619520
10MP0002638_abnormal_pupillary_reflex2.73113285
11MP0006276_abnormal_autonomic_nervous2.39626846
12MP0002751_abnormal_autonomic_nervous2.38759114
13MP0004270_analgesia2.16398906
14MP0001486_abnormal_startle_reflex2.12893585
15MP0004859_abnormal_synaptic_plasticity2.04206109
16MP0001968_abnormal_touch/_nociception1.82498638
17MP0004924_abnormal_behavior1.79082306
18MP0005386_behavior/neurological_phenoty1.79082306
19MP0005085_abnormal_gallbladder_physiolo1.76489987
20MP0003806_abnormal_nucleotide_metabolis1.75820516
21MP0000372_irregular_coat_pigmentation1.73677823
22MP0002734_abnormal_mechanical_nocicepti1.69054257
23MP0003566_abnormal_cell_adhesion1.67933340
24MP0002909_abnormal_adrenal_gland1.65577016
25MP0001905_abnormal_dopamine_level1.63315495
26MP0005360_urolithiasis1.62007908
27MP0002184_abnormal_innervation1.61526355
28MP0001440_abnormal_grooming_behavior1.60980513
29MP0010386_abnormal_urinary_bladder1.56641808
30MP0002127_abnormal_cardiovascular_syste1.56391556
31MP0000534_abnormal_ureter_morphology1.56236606
32MP0003635_abnormal_synaptic_transmissio1.55917621
33MP0003567_abnormal_fetal_cardiomyocyte1.48307975
34MP0005623_abnormal_meninges_morphology1.47485613
35MP0001970_abnormal_pain_threshold1.46828663
36MP0002090_abnormal_vision1.45139354
37MP0000538_abnormal_urinary_bladder1.45025291
38MP0000049_abnormal_middle_ear1.44591071
39MP0004142_abnormal_muscle_tone1.41097050
40MP0003279_aneurysm1.37961022
41MP0001963_abnormal_hearing_physiology1.36996975
42MP0002089_abnormal_postnatal_growth/wei1.35149892
43MP0005084_abnormal_gallbladder_morpholo1.34202465
44MP0000751_myopathy1.31754219
45MP0005248_abnormal_Harderian_gland1.26477233
46MP0005535_abnormal_body_temperature1.26215691
47MP0000026_abnormal_inner_ear1.24560604
48MP0003075_altered_response_to1.24330810
49MP0008874_decreased_physiological_sensi1.21628877
50MP0003866_abnormal_defecation1.19432596
51MP0002249_abnormal_larynx_morphology1.17569336
52MP0000778_abnormal_nervous_system1.16635621
53MP0002733_abnormal_thermal_nociception1.16346797
54MP0004858_abnormal_nervous_system1.15630933
55MP0003942_abnormal_urinary_system1.15325742
56MP0009745_abnormal_behavioral_response1.12433859
57MP0002272_abnormal_nervous_system1.11164816
58MP0003880_abnormal_central_pattern1.10498682
59MP0008872_abnormal_physiological_respon1.08535014
60MP0002064_seizures1.08282049
61MP0001879_abnormal_lymphatic_vessel1.07741518
62MP0001348_abnormal_lacrimal_gland1.07079494
63MP0005197_abnormal_uvea_morphology1.00056434
64MP0004742_abnormal_vestibular_system0.99642016
65MP0003011_delayed_dark_adaptation0.99583960
66MP0003941_abnormal_skin_development0.97127978
67MP0002557_abnormal_social/conspecific_i0.96256146
68MP0008875_abnormal_xenobiotic_pharmacok0.95806286
69MP0009764_decreased_sensitivity_to0.93680032
70MP0002837_dystrophic_cardiac_calcinosis0.90683607
71MP0005408_hypopigmentation0.90610961
72MP0001188_hyperpigmentation0.90565846
73MP0003122_maternal_imprinting0.89909223
74MP0000678_abnormal_parathyroid_gland0.88915472
75MP0004885_abnormal_endolymph0.88068623
76MP0004085_abnormal_heartbeat0.85371175
77MP0002332_abnormal_exercise_endurance0.84487820
78MP0000579_abnormal_nail_morphology0.84205081
79MP0002067_abnormal_sensory_capabilities0.81186368
80MP0005167_abnormal_blood-brain_barrier0.80652684
81MP0004510_myositis0.80630693
82MP0008789_abnormal_olfactory_epithelium0.79308786
83MP0001270_distended_abdomen0.78143976
84MP0005076_abnormal_cell_differentiation0.78033629
85MP0002177_abnormal_outer_ear0.77679449
86MP0002168_other_aberrant_phenotype0.77530615
87MP0010368_abnormal_lymphatic_system0.76913601
88MP0001501_abnormal_sleep_pattern0.76388786
89MP0003632_abnormal_nervous_system0.76159815
90MP0003633_abnormal_nervous_system0.75635728
91MP0002882_abnormal_neuron_morphology0.74472267
92MP0008569_lethality_at_weaning0.73158461
93MP0003329_amyloid_beta_deposits0.73032779
94MP0002063_abnormal_learning/memory/cond0.72509896
95MP0000767_abnormal_smooth_muscle0.71099883
96MP0002752_abnormal_somatic_nervous0.69900181
97MP0004883_abnormal_blood_vessel0.69152073
98MP0003724_increased_susceptibility_to0.68456790
99MP0004484_altered_response_of0.68008737
100MP0004272_abnormal_basement_membrane0.67967203

Predicted human phenotypes

RankGene SetZ-score
1Asymmetry of the thorax (HP:0001555)5.86052032
2Macroorchidism (HP:0000053)4.73422373
3Hyperventilation (HP:0002883)4.59771464
4Exotropia (HP:0000577)4.34787578
5Hypoventilation (HP:0002791)4.09362161
6Infantile muscular hypotonia (HP:0008947)3.93855631
7Hypothermia (HP:0002045)3.75645414
8Broad-based gait (HP:0002136)3.74984877
9Prolonged QT interval (HP:0001657)3.64838672
10Fair hair (HP:0002286)3.59005367
11Abnormality of cells of the erythroid lineage (HP:0012130)3.49548295
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.47555614
13Clumsiness (HP:0002312)3.45079319
14Agitation (HP:0000713)3.38838493
15Inappropriate behavior (HP:0000719)3.18793575
16Distal lower limb amyotrophy (HP:0008944)3.17673583
17Hypotrichosis (HP:0001006)3.12468444
18Autoamputation (HP:0001218)3.05084407
19Orthostatic hypotension (HP:0001278)3.03310487
20Poor eye contact (HP:0000817)3.02356969
21Mesangial abnormality (HP:0001966)2.98310630
22Absent speech (HP:0001344)2.89894381
23Stenosis of the external auditory canal (HP:0000402)2.89650687
24Secondary amenorrhea (HP:0000869)2.87196209
25Hypoplastic nipples (HP:0002557)2.83489685
26Lower limb amyotrophy (HP:0007210)2.83489284
27Myokymia (HP:0002411)2.82256177
28Congenital, generalized hypertrichosis (HP:0004540)2.76411477
29Bell-shaped thorax (HP:0001591)2.74463140
30Palpebral edema (HP:0100540)2.64990890
31Abnormal social behavior (HP:0012433)2.63661764
32Impaired social interactions (HP:0000735)2.63661764
33Restlessness (HP:0000711)2.63017174
34Parakeratosis (HP:0001036)2.61911852
35Tubulointerstitial fibrosis (HP:0005576)2.57063891
36Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.52526532
37Myotonia (HP:0002486)2.52099336
38Conjugated hyperbilirubinemia (HP:0002908)2.43902299
39Truncal ataxia (HP:0002078)2.42523398
40Generalized hypopigmentation of hair (HP:0011358)2.41169469
41Psychosis (HP:0000709)2.41146798
42Blue irides (HP:0000635)2.40703457
43Anxiety (HP:0000739)2.40195214
44Spastic gait (HP:0002064)2.34840824
45Broad face (HP:0000283)2.31086988
46Abnormal eating behavior (HP:0100738)2.30578648
47Vacuolated lymphocytes (HP:0001922)2.28616664
48Abnormal EKG (HP:0003115)2.26200264
49Anhidrosis (HP:0000970)2.25285765
50Choreoathetosis (HP:0001266)2.23937570
51Hypoalbuminemia (HP:0003073)2.22580105
52Abnormal albumin level (HP:0012116)2.22580105
53Neonatal hypoglycemia (HP:0001998)2.19634752
54Aplasia/Hypoplasia affecting the retina (HP:0008061)2.19154852
55Deep venous thrombosis (HP:0002625)2.19076572
56Abnormality of the axillary hair (HP:0100134)2.17392171
57Abnormality of secondary sexual hair (HP:0009888)2.17392171
58Broad metatarsal (HP:0001783)2.12358147
59Aplasia/Hypoplasia of the macula (HP:0008059)2.12315118
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11178715
61Morphological abnormality of the middle ear (HP:0008609)2.10128804
62Striae distensae (HP:0001065)2.09537034
63Keratoconus (HP:0000563)2.06148922
64Increased corneal curvature (HP:0100692)2.06148922
65Impaired vibration sensation in the lower limbs (HP:0002166)2.05940200
66Joint swelling (HP:0001386)2.03002098
67Severe visual impairment (HP:0001141)2.01198201
68Tented upper lip vermilion (HP:0010804)2.00564450
69Neurofibrillary tangles (HP:0002185)1.98267760
70Abnormal autonomic nervous system physiology (HP:0012332)1.95878076
71Acrocyanosis (HP:0001063)1.95817339
72Protruding ear (HP:0000411)1.95135742
73Ankle clonus (HP:0011448)1.93478490
74Abnormality of the corticospinal tract (HP:0002492)1.91475497
75Arthropathy (HP:0003040)1.89219485
76Fragile skin (HP:0001030)1.88902005
77Polyphagia (HP:0002591)1.87395414
78Long toe (HP:0010511)1.87110308
79Hypoplasia of the pons (HP:0012110)1.86506255
80Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.84808810
81Aplasia/Hypoplasia of the nipples (HP:0006709)1.80122989
82Amblyopia (HP:0000646)1.79218917
83Type II lissencephaly (HP:0007260)1.78720089
84Aplasia/Hypoplasia of the lens (HP:0008063)1.77462257
85Aplasia/hypoplasia of the uterus (HP:0008684)1.75589487
86Thick nail (HP:0001805)1.72989207
87Nasal speech (HP:0001611)1.71530113
88Hypercortisolism (HP:0001578)1.71228054
89Flat occiput (HP:0005469)1.68560466
90Abnormal number of erythroid precursors (HP:0012131)1.67668692
91Macrocytic anemia (HP:0001972)1.66097366
92Cerebral inclusion bodies (HP:0100314)1.64251642
93Abnormality of the vitreous humor (HP:0004327)1.62045110
94Tubulointerstitial abnormality (HP:0001969)1.60846638
95Protrusio acetabuli (HP:0003179)1.59373529
96Brachycephaly (HP:0000248)1.59170277
97Nail dystrophy (HP:0008404)1.57873344
98Hepatoblastoma (HP:0002884)1.55862239
99EMG: myopathic abnormalities (HP:0003458)1.55246530
100Rapidly progressive (HP:0003678)1.54828976

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK36.05949906
2NTRK13.92203059
3MAP3K93.88123137
4MAP2K43.60695201
5MAP2K33.14455633
6GRK73.05629558
7MAP2K72.99674954
8MUSK2.87898733
9HIPK22.23140408
10MAP2K62.21104569
11MATK1.89400215
12FES1.82237207
13GRK51.71475266
14MAP3K41.60367985
15TGFBR11.57438643
16DYRK1B1.55427694
17TGFBR21.50927646
18EPHB11.40457509
19ERBB21.36814778
20LRRK21.36630503
21MAPK151.35992022
22EPHA21.30435038
23PTK2B1.29625232
24EPHB21.27992590
25DDR21.25355423
26MAP3K121.21290930
27TIE11.15811673
28MAP3K11.13822495
29TRPM71.12475808
30DYRK21.12075907
31BMX1.08429426
32MAP2K11.02476829
33MYLK0.99924958
34MARK10.94409893
35MAP3K100.92129526
36PLK20.91500383
37BRD40.90970585
38MAPK120.90184849
39MAPK130.90075078
40PAK40.89821039
41EPHA40.88053275
42WNK10.87662653
43ADRBK10.85374254
44IKBKE0.84979743
45UHMK10.84571414
46MAPK70.82270986
47LATS20.81636412
48MAP3K20.80703619
49MAPKAPK50.79864192
50PRKD10.77432483
51ILK0.76622049
52TBK10.75702196
53VRK10.74377039
54TTN0.73972565
55MINK10.70956409
56CSNK1G30.65946633
57CDK190.65445872
58PRKCE0.64930090
59ZAP700.63950309
60PRKCG0.62145275
61IRAK10.61487826
62CSF1R0.61480540
63CDK50.60979714
64BLK0.60329290
65PTK60.59579228
66PIM20.57472342
67STK240.56247970
68RIPK10.53872621
69PRKCH0.52253279
70DAPK30.52056346
71ARAF0.51925066
72SRPK10.51056658
73CSNK1G20.50448903
74PRKCZ0.46850730
75CCNB10.45674711
76PRKD20.43799248
77TESK10.41294718
78DYRK30.41282787
79MAP3K110.39132216
80KDR0.38291334
81MAP3K60.37509776
82PRKACA0.37291969
83PKN10.37032835
84KSR20.35473841
85MAPK40.34804091
86INSR0.33838338
87IRAK20.33651286
88MAPK90.33196740
89PRKACG0.31790827
90CSNK1G10.31371639
91IGF1R0.31302721
92FGR0.30951746
93ERBB40.30870352
94CAMK2B0.29774879
95FYN0.29591373
96CASK0.28058129
97CAMK2G0.27119875
98SRC0.26888586
99GSK3A0.26362915
100DYRK1A0.26054428

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.14683971
2Ribosome_Homo sapiens_hsa030103.81510729
3Phenylalanine metabolism_Homo sapiens_hsa003603.29547785
4Histidine metabolism_Homo sapiens_hsa003403.11636386
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.30842951
6Tyrosine metabolism_Homo sapiens_hsa003502.29900446
7Cocaine addiction_Homo sapiens_hsa050302.22274029
8Tryptophan metabolism_Homo sapiens_hsa003802.08677678
9Butanoate metabolism_Homo sapiens_hsa006501.76946636
10Cholinergic synapse_Homo sapiens_hsa047251.70105893
11Dopaminergic synapse_Homo sapiens_hsa047281.63396006
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61656594
13Steroid biosynthesis_Homo sapiens_hsa001001.58658532
14Amphetamine addiction_Homo sapiens_hsa050311.56205086
15African trypanosomiasis_Homo sapiens_hsa051431.45595617
16Olfactory transduction_Homo sapiens_hsa047401.36204102
17Serotonergic synapse_Homo sapiens_hsa047261.34526489
18Alcoholism_Homo sapiens_hsa050341.26418360
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25920740
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25446380
21Circadian entrainment_Homo sapiens_hsa047131.20917205
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20165503
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19985317
24Fatty acid degradation_Homo sapiens_hsa000711.13272065
25GnRH signaling pathway_Homo sapiens_hsa049121.09042042
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.08956874
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07338489
28Neurotrophin signaling pathway_Homo sapiens_hsa047221.05897788
29Platelet activation_Homo sapiens_hsa046111.05245810
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04949660
31Alzheimers disease_Homo sapiens_hsa050101.04910804
32VEGF signaling pathway_Homo sapiens_hsa043701.04404773
33Axon guidance_Homo sapiens_hsa043601.02858399
34Gap junction_Homo sapiens_hsa045401.02300958
35Glutamatergic synapse_Homo sapiens_hsa047241.00011787
36Renin secretion_Homo sapiens_hsa049240.96685163
37Dilated cardiomyopathy_Homo sapiens_hsa054140.94310567
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93984870
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93777303
40Primary bile acid biosynthesis_Homo sapiens_hsa001200.93256182
41Estrogen signaling pathway_Homo sapiens_hsa049150.91407923
42Arginine biosynthesis_Homo sapiens_hsa002200.90605770
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89465101
44Parkinsons disease_Homo sapiens_hsa050120.86974793
45Amoebiasis_Homo sapiens_hsa051460.86804865
46* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86527841
47Prolactin signaling pathway_Homo sapiens_hsa049170.84534399
48Fatty acid elongation_Homo sapiens_hsa000620.82674694
49Fatty acid metabolism_Homo sapiens_hsa012120.79033768
50Insulin secretion_Homo sapiens_hsa049110.78380782
51Bile secretion_Homo sapiens_hsa049760.78278746
52Focal adhesion_Homo sapiens_hsa045100.77740262
53GABAergic synapse_Homo sapiens_hsa047270.76017833
54Arginine and proline metabolism_Homo sapiens_hsa003300.75763499
55Complement and coagulation cascades_Homo sapiens_hsa046100.75759591
56Prion diseases_Homo sapiens_hsa050200.75342126
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72625293
58Oxidative phosphorylation_Homo sapiens_hsa001900.72207465
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71910209
60Melanogenesis_Homo sapiens_hsa049160.70140340
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69184897
62* Leukocyte transendothelial migration_Homo sapiens_hsa046700.68954519
63Oxytocin signaling pathway_Homo sapiens_hsa049210.68335572
64Calcium signaling pathway_Homo sapiens_hsa040200.67869474
65Long-term depression_Homo sapiens_hsa047300.65872474
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63530845
67Salivary secretion_Homo sapiens_hsa049700.63499590
68Nicotine addiction_Homo sapiens_hsa050330.61873076
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61404872
70ECM-receptor interaction_Homo sapiens_hsa045120.59180405
71Glioma_Homo sapiens_hsa052140.58787384
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57417628
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.56890415
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56500274
75Cardiac muscle contraction_Homo sapiens_hsa042600.55437553
76Pertussis_Homo sapiens_hsa051330.55435896
77Leishmaniasis_Homo sapiens_hsa051400.54901785
78Propanoate metabolism_Homo sapiens_hsa006400.54734754
79cAMP signaling pathway_Homo sapiens_hsa040240.54307119
80Type II diabetes mellitus_Homo sapiens_hsa049300.54271271
81Rap1 signaling pathway_Homo sapiens_hsa040150.54201540
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53398025
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53119140
84Morphine addiction_Homo sapiens_hsa050320.52351318
85Malaria_Homo sapiens_hsa051440.52251424
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51770023
87Salmonella infection_Homo sapiens_hsa051320.51177543
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49800931
89Long-term potentiation_Homo sapiens_hsa047200.49333838
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49202210
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48538817
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48064949
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.47431423
94Chemical carcinogenesis_Homo sapiens_hsa052040.46409431
95Chronic myeloid leukemia_Homo sapiens_hsa052200.46228696
96Dorso-ventral axis formation_Homo sapiens_hsa043200.43274416
97Synaptic vesicle cycle_Homo sapiens_hsa047210.43223075
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42117728
99Proteoglycans in cancer_Homo sapiens_hsa052050.41676621
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41091403

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