CLDN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal epithelial cell development (GO:0060576)7.38881956
2hemidesmosome assembly (GO:0031581)5.34865941
3hepatocyte apoptotic process (GO:0097284)5.16978910
4trophectodermal cell differentiation (GO:0001829)4.92401545
5bundle of His cell to Purkinje myocyte communication (GO:0086069)4.69408710
6* calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.56220787
7lung-associated mesenchyme development (GO:0060484)4.53609785
8regulation of histone H3-K27 methylation (GO:0061085)4.20312401
9regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.18771190
10folic acid metabolic process (GO:0046655)4.02644569
11folic acid transport (GO:0015884)4.02562861
12tight junction assembly (GO:0070830)3.94590502
13COPI coating of Golgi vesicle (GO:0048205)3.94116618
14Golgi transport vesicle coating (GO:0048200)3.94116618
15ear development (GO:0043583)3.93899234
16formation of translation preinitiation complex (GO:0001731)3.92948562
17keratinocyte development (GO:0003334)3.92599096
18* regulation of water loss via skin (GO:0033561)3.90320194
19labyrinthine layer development (GO:0060711)3.87948722
20positive regulation of epidermal cell differentiation (GO:0045606)3.81699952
21regulation of cardioblast differentiation (GO:0051890)3.77603462
22desmosome organization (GO:0002934)3.73622804
23axonemal dynein complex assembly (GO:0070286)3.69862156
24negative regulation of cell fate specification (GO:0009996)3.69652600
25ribosome assembly (GO:0042255)3.69584234
26purine nucleobase biosynthetic process (GO:0009113)3.65255681
27primary alcohol catabolic process (GO:0034310)3.62099179
28regulation of cell proliferation involved in kidney development (GO:1901722)3.58724414
29* water homeostasis (GO:0030104)3.54008068
30positive regulation of keratinocyte differentiation (GO:0045618)3.50625431
31regulation of cholesterol homeostasis (GO:2000188)3.42922974
32skin morphogenesis (GO:0043589)3.41917307
33nucleobase biosynthetic process (GO:0046112)3.40516307
34amyloid precursor protein catabolic process (GO:0042987)3.35679008
35activation of Rac GTPase activity (GO:0032863)3.34696312
36regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.32226068
37protein retention in ER lumen (GO:0006621)3.30066327
38maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.24559789
39O-glycan processing (GO:0016266)3.24389209
40regulation of keratinocyte differentiation (GO:0045616)3.24231990
41epithelial cell differentiation involved in prostate gland development (GO:0060742)3.20926405
42proline biosynthetic process (GO:0006561)3.20218539
43endothelial cell chemotaxis (GO:0035767)3.20007285
44regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.18803368
45positive regulation of pseudopodium assembly (GO:0031274)3.18634720
46negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.17874540
47wound healing, spreading of epidermal cells (GO:0035313)3.17676656
48amyloid precursor protein metabolic process (GO:0042982)3.17393302
49ethanol metabolic process (GO:0006067)3.12319812
50modified amino acid transport (GO:0072337)3.11802387
51pyrimidine-containing compound transmembrane transport (GO:0072531)3.11787920
52regulation of hippo signaling (GO:0035330)3.11786097
53epithelial cell-cell adhesion (GO:0090136)3.11647614
54proteasome assembly (GO:0043248)3.11608478
55regulation of translational termination (GO:0006449)3.11459254
56cytoskeletal anchoring at plasma membrane (GO:0007016)3.09143522
57regulation of viral release from host cell (GO:1902186)3.08648667
58regulation of translation in response to stress (GO:0043555)3.07125252
59glutathione biosynthetic process (GO:0006750)3.06731527
60retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.04601213
61cardiac right ventricle morphogenesis (GO:0003215)3.03027428
62response to food (GO:0032094)3.02298162
63establishment of apical/basal cell polarity (GO:0035089)3.01173219
64branching involved in mammary gland duct morphogenesis (GO:0060444)3.01124568
65columnar/cuboidal epithelial cell development (GO:0002066)2.99917126
66dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.99566991
67regulation of pseudopodium assembly (GO:0031272)2.99270324
68regulation of transforming growth factor beta1 production (GO:0032908)2.99144743
69phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.99091798
70negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.97487385
71surfactant homeostasis (GO:0043129)2.95084629
72NADH metabolic process (GO:0006734)2.94558018
73cell differentiation involved in embryonic placenta development (GO:0060706)2.93949509
74intestinal absorption (GO:0050892)2.92807439
75negative regulation of kidney development (GO:0090185)2.91544577
76blastocyst development (GO:0001824)2.88980415
77GDP-mannose metabolic process (GO:0019673)2.87674925
78positive regulation of SMAD protein import into nucleus (GO:0060391)2.86038705
79positive regulation of epidermis development (GO:0045684)2.85772916
80regulation of posttranscriptional gene silencing (GO:0060147)2.85228557
81regulation of gene silencing by miRNA (GO:0060964)2.85228557
82regulation of gene silencing by RNA (GO:0060966)2.85228557
83sphingomyelin metabolic process (GO:0006684)2.85041743
84semaphorin-plexin signaling pathway (GO:0071526)2.84539992
85regulation of apoptotic process involved in morphogenesis (GO:1902337)2.84335445
86regulation of cell fate specification (GO:0042659)2.84233395
87atrioventricular valve morphogenesis (GO:0003181)2.83846796
88negative regulation of keratinocyte proliferation (GO:0010839)2.83123467
89anterior/posterior axis specification, embryo (GO:0008595)2.83045315
90regulation of ruffle assembly (GO:1900027)2.82139314
91muscle organ morphogenesis (GO:0048644)2.81381270
92regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.81326532
93striated muscle atrophy (GO:0014891)2.80999089
94lung lobe morphogenesis (GO:0060463)2.80816267
95vitamin transmembrane transport (GO:0035461)2.79542282
96negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.79239605
97negative regulation of cell fate commitment (GO:0010454)2.79216059
98renal system process involved in regulation of blood volume (GO:0001977)2.78504717
99cell fate commitment involved in formation of primary germ layer (GO:0060795)2.78206238
100nonribosomal peptide biosynthetic process (GO:0019184)2.77292820
101peptidyl-tyrosine autophosphorylation (GO:0038083)2.75848945
102positive regulation of fatty acid beta-oxidation (GO:0032000)2.73225150
103regulation of interleukin-13 production (GO:0032656)2.73179302
104motile cilium assembly (GO:0044458)2.72773297
105gap junction assembly (GO:0016264)2.71808080
106diterpenoid biosynthetic process (GO:0016102)2.71779067
107flavonoid metabolic process (GO:0009812)2.69414573
108planar cell polarity pathway involved in neural tube closure (GO:0090179)2.69336015
109apoptotic process involved in morphogenesis (GO:0060561)2.67663465
110cell-cell junction maintenance (GO:0045217)2.65327459
111regulation of fatty acid beta-oxidation (GO:0031998)2.65213721
112* establishment of skin barrier (GO:0061436)2.63592747
113* multicellular organismal water homeostasis (GO:0050891)2.61976135
114epoxygenase P450 pathway (GO:0019373)2.61889582
115wound healing, spreading of cells (GO:0044319)2.61662315
116keratinocyte proliferation (GO:0043616)2.60808573
117anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.60488267
118auditory receptor cell differentiation (GO:0042491)2.59665821
119galactose catabolic process (GO:0019388)2.59282345
120regulation of SMAD protein import into nucleus (GO:0060390)2.58770137
121lung epithelium development (GO:0060428)2.58629589
122regulation of cholesterol biosynthetic process (GO:0045540)2.58198592
123ectoderm development (GO:0007398)2.58118546
124ventricular cardiac muscle cell action potential (GO:0086005)2.57434307
125morphogenesis of embryonic epithelium (GO:0016331)2.56947162
126membrane budding (GO:0006900)2.56672547
127positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.55990807
128mammary gland epithelial cell differentiation (GO:0060644)2.54972902
129mitotic metaphase plate congression (GO:0007080)2.54723565
130maintenance of gastrointestinal epithelium (GO:0030277)2.54637333
131branching involved in salivary gland morphogenesis (GO:0060445)2.54166768
132negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.53925272
133positive regulation of catenin import into nucleus (GO:0035413)2.53855479
134regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.52959073
135positive regulation of Cdc42 GTPase activity (GO:0043089)2.52944690
136regulation of metalloenzyme activity (GO:0048552)2.52402016
137respiratory tube development (GO:0030323)2.52186400
138maturation of SSU-rRNA (GO:0030490)2.51952928
139establishment or maintenance of apical/basal cell polarity (GO:0035088)2.51557229
140establishment or maintenance of bipolar cell polarity (GO:0061245)2.51557229
141molting cycle (GO:0042303)2.51108778
142hair cycle (GO:0042633)2.51108778
143mesodermal cell differentiation (GO:0048333)2.49486105
144regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.49006712
145paraxial mesoderm development (GO:0048339)2.47946947
146cell-cell junction assembly (GO:0007043)2.46568902
147regulation of cellular amino acid metabolic process (GO:0006521)2.44213608
148keratinization (GO:0031424)2.43895168
149keratinocyte differentiation (GO:0030216)2.43829926
150regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.43667921
151ribosome biogenesis (GO:0042254)2.41063939
152polarized epithelial cell differentiation (GO:0030859)2.39590011
153nodal signaling pathway (GO:0038092)2.39064434
154protein autoprocessing (GO:0016540)2.38174551
155establishment of monopolar cell polarity (GO:0061162)2.37716315
156establishment or maintenance of monopolar cell polarity (GO:0061339)2.37716315
157establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.37380839
158positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.36683230
159signal transduction involved in DNA damage checkpoint (GO:0072422)2.36603779
160signal transduction involved in DNA integrity checkpoint (GO:0072401)2.36603779
161interferon-gamma secretion (GO:0072643)12.2391610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.02926352
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.32811007
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.08865380
4ESR1_20079471_ChIP-ChIP_T-47D_Human3.01023579
5ZNF263_19887448_ChIP-Seq_K562_Human2.82401005
6* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.82049471
7* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.57152600
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.54478215
9* MYC_18555785_ChIP-Seq_MESCs_Mouse2.52741092
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.31694141
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27306621
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.24763801
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.17416231
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.17331784
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.10823039
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.10823039
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.10823039
18* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.08130919
19AR_21909140_ChIP-Seq_LNCAP_Human2.03532571
20* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.01716427
21* LXR_22292898_ChIP-Seq_THP-1_Human2.00102574
22* SOX2_20726797_ChIP-Seq_SW620_Human1.98935831
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93154661
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.92657376
25NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87482209
26* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.81378152
27* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79664724
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77505923
29* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77003667
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.75616005
31* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.75308937
32* ATF3_27146783_Chip-Seq_COLON_Human1.74354246
33* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.73606428
34PPARA_22158963_ChIP-Seq_LIVER_Mouse1.73394257
35EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.73380580
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72996199
37* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71344879
38KLF5_25053715_ChIP-Seq_YYC3_Human1.70142936
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.69951075
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.68738890
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68174063
42E2F7_22180533_ChIP-Seq_HELA_Human1.67433532
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65493758
44FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63717358
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62157104
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.61493270
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59578224
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58842121
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58516246
50TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.58382355
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.54707915
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54689642
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53262330
54* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51888062
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.51166949
56RACK7_27058665_Chip-Seq_MCF-7_Human1.50595874
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49158635
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47922816
59* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47374628
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47156134
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.46679293
62SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46602036
63* GATA6_25053715_ChIP-Seq_YYC3_Human1.46433002
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45735997
65AHR_22903824_ChIP-Seq_MCF-7_Human1.45357688
66* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.44787673
67* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.40932491
68* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40545645
69* CREB1_26743006_Chip-Seq_LNCaP_Human1.40425558
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39588520
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39063077
72* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.36239182
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.35695536
74* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.35054547
75XRN2_22483619_ChIP-Seq_HELA_Human1.34964487
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.32926347
77* GATA4_25053715_ChIP-Seq_YYC3_Human1.32801917
78* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32131131
79* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31999579
80* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31999579
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30259067
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.29834640
83ERG_21242973_ChIP-ChIP_JURKAT_Human1.29152302
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28819363
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28465042
86SMC4_20622854_ChIP-Seq_HELA_Human1.27203746
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25533998
88* RUNX1_27514584_Chip-Seq_MCF-7_Human1.25259456
89* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.25210378
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25062357
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24357483
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.23827265
93P68_20966046_ChIP-Seq_HELA_Human1.23768855
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.22862158
95* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.22463774
96KDM5A_27292631_Chip-Seq_BREAST_Human1.22197125
97SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21968384
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.21324085
99TP63_22573176_ChIP-Seq_HFKS_Human1.20948806
100CLOCK_20551151_ChIP-Seq_293T_Human1.19563755
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.18155941
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17058181
103ELF5_23300383_ChIP-Seq_T47D_Human1.15685200
104* CDX2_20551321_ChIP-Seq_CACO-2_Human1.13355863
105KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12957862
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12356423
107* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.12082504
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11874624
109* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10798160
110KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09818500
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.09704908
112* TCF7_22412390_ChIP-Seq_EML_Mouse1.09513718
113KDM2B_26808549_Chip-Seq_K562_Human1.08285213
114* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07612997
115* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07216851
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07082018
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06800293
118TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.06742643
119* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.06205354
120KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06128226
121* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05820231
122* CHD1_26751641_Chip-Seq_LNCaP_Human1.05460816
123* FOXO3_23340844_ChIP-Seq_DLD1_Human1.05182218
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05172250
125NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05018002
126* GATA3_24758297_ChIP-Seq_MCF-7_Human1.04826515
127MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04155026
128MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03158834
129CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02523548
130* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02418545
131NANOG_21062744_ChIP-ChIP_HESCs_Human1.02297897
132PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01584406
133CTCF_27219007_Chip-Seq_Bcells_Human1.01512651
134TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00781535
135LXR_22158963_ChIP-Seq_LIVER_Mouse1.00597783
136BCOR_27268052_Chip-Seq_Bcells_Human1.00105250
137DCP1A_22483619_ChIP-Seq_HELA_Human0.99715282
138STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99531030
139* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99412557
140SA1_27219007_Chip-Seq_ERYTHROID_Human0.99272151
141TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99181787
142* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99082585
143GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.98863857
144P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98689567
145GABP_19822575_ChIP-Seq_HepG2_Human0.98610929
146* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98571989
147NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98514330
148ELK3_25401928_ChIP-Seq_HUVEC_Human0.98137142
149STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98107984
150RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98056282
151EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98009715
152P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97879220
153SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97502119
154SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93861670
155CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90815533
156AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90747583
157RARB_24833708_ChIP-Seq_LIVER_Mouse0.89051208

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.92549114
2MP0004264_abnormal_extraembryonic_tissu4.05148594
3MP0003693_abnormal_embryo_hatching3.83927180
4MP0010352_gastrointestinal_tract_polyps3.48808236
5MP0000537_abnormal_urethra_morphology3.25772692
6MP0002796_impaired_skin_barrier2.93672210
7MP0010678_abnormal_skin_adnexa2.89462871
8MP0004957_abnormal_blastocyst_morpholog2.88039592
9MP0009840_abnormal_foam_cell2.86141018
10MP0002254_reproductive_system_inflammat2.68323870
11MP0002098_abnormal_vibrissa_morphology2.26941853
12MP0003566_abnormal_cell_adhesion2.22197469
13MP0000383_abnormal_hair_follicle2.20859639
14MP0009780_abnormal_chondrocyte_physiolo2.20710979
15MP0004782_abnormal_surfactant_physiolog2.17383771
16MP0001849_ear_inflammation2.15661901
17MP0003878_abnormal_ear_physiology2.03405824
18MP0005377_hearing/vestibular/ear_phenot2.03405824
19MP0005501_abnormal_skin_physiology2.03394741
20MP0003111_abnormal_nucleus_morphology2.00527205
21MP0008875_abnormal_xenobiotic_pharmacok2.00324072
22MP0005083_abnormal_biliary_tract1.88850242
23MP0003191_abnormal_cellular_cholesterol1.84997170
24MP0000678_abnormal_parathyroid_gland1.80488276
25MP0001216_abnormal_epidermal_layer1.67734038
26MP0001873_stomach_inflammation1.65900223
27MP0000462_abnormal_digestive_system1.62829612
28MP0003941_abnormal_skin_development1.59587691
29MP0000627_abnormal_mammary_gland1.58344824
30MP0005365_abnormal_bile_salt1.56738630
31MP0003119_abnormal_digestive_system1.55873802
32MP0003453_abnormal_keratinocyte_physiol1.55151677
33MP0001664_abnormal_digestion1.54608720
34MP0003866_abnormal_defecation1.53717485
35MP0003077_abnormal_cell_cycle1.50445574
36MP0004043_abnormal_pH_regulation1.47957753
37MP0001765_abnormal_ion_homeostasis1.47827602
38MP0001730_embryonic_growth_arrest1.45754588
39MP0003718_maternal_effect1.45294076
40MP0004019_abnormal_vitamin_homeostasis1.45260560
41MP0005360_urolithiasis1.44665161
42MP0003315_abnormal_perineum_morphology1.43507898
43MP0000377_abnormal_hair_follicle1.43463430
44MP0005023_abnormal_wound_healing1.42687660
45MP0005409_darkened_coat_color1.37362036
46MP0003705_abnormal_hypodermis_morpholog1.36103786
47MP0002139_abnormal_hepatobiliary_system1.35691113
48MP0005380_embryogenesis_phenotype1.35414384
49MP0001672_abnormal_embryogenesis/_devel1.35414384
50MP0005451_abnormal_body_composition1.31513579
51MP0000762_abnormal_tongue_morphology1.31133523
52MP0002086_abnormal_extraembryonic_tissu1.31048724
53MP0000647_abnormal_sebaceous_gland1.29499089
54MP0000516_abnormal_urinary_system1.28944165
55MP0005367_renal/urinary_system_phenotyp1.28944165
56MP0009053_abnormal_anal_canal1.27422725
57MP0005248_abnormal_Harderian_gland1.27398682
58MP0005275_abnormal_skin_tensile1.26378156
59MP0008932_abnormal_embryonic_tissue1.26088398
60MP0001756_abnormal_urination1.25110342
61MP0002060_abnormal_skin_morphology1.20716690
62MP0002088_abnormal_embryonic_growth/wei1.20213751
63MP0001697_abnormal_embryo_size1.19946960
64MP0000350_abnormal_cell_proliferation1.19696377
65MP0004858_abnormal_nervous_system1.19333201
66MP0005076_abnormal_cell_differentiation1.18740600
67MP0005058_abnormal_lysosome_morphology1.18200636
68MP0005085_abnormal_gallbladder_physiolo1.16114426
69MP0002085_abnormal_embryonic_tissue1.15848700
70MP0000490_abnormal_crypts_of1.15490684
71MP0003984_embryonic_growth_retardation1.15369362
72MP0010155_abnormal_intestine_physiology1.14753712
73MP0002249_abnormal_larynx_morphology1.14096150
74MP0000477_abnormal_intestine_morphology1.13812473
75MP0004272_abnormal_basement_membrane1.13062415
76MP0002234_abnormal_pharynx_morphology1.11114681
77MP0002084_abnormal_developmental_patter1.10996354
78MP0003183_abnormal_peptide_metabolism1.06187668
79MP0002080_prenatal_lethality1.04993275
80MP0010030_abnormal_orbit_morphology1.02880363
81MP0001881_abnormal_mammary_gland1.02690166
82MP0002653_abnormal_ependyma_morphology1.02634934
83MP0000613_abnormal_salivary_gland1.02240136
84MP0005670_abnormal_white_adipose1.01156264
85MP0003936_abnormal_reproductive_system0.99574585
86MP0002111_abnormal_tail_morphology0.98170481
87MP0001666_abnormal_nutrient_absorption0.97805941
88MP0003937_abnormal_limbs/digits/tail_de0.96788555
89MP0004185_abnormal_adipocyte_glucose0.95731802
90MP0000579_abnormal_nail_morphology0.94894793
91MP0009643_abnormal_urine_homeostasis0.93726334
92MP0001346_abnormal_lacrimal_gland0.92989228
93MP0000566_synostosis0.91554121
94MP0005395_other_phenotype0.90896263
95MP0004197_abnormal_fetal_growth/weight/0.90449111
96MP0000467_abnormal_esophagus_morphology0.89969390
97MP0005636_abnormal_mineral_homeostasis0.88901087
98MP0004381_abnormal_hair_follicle0.86964832
99MP0005310_abnormal_salivary_gland0.86862057
100MP0006054_spinal_hemorrhage0.85552572
101MP0002896_abnormal_bone_mineralization0.85282884
102MP0003890_abnormal_embryonic-extraembry0.84953210
103MP0000538_abnormal_urinary_bladder0.84934661
104MP0010771_integument_phenotype0.84756251
105MP0003300_gastrointestinal_ulcer0.84228558
106MP0000367_abnormal_coat/_hair0.83166820
107MP0000681_abnormal_thyroid_gland0.83086214
108MP0003123_paternal_imprinting0.81078706
109MP0001727_abnormal_embryo_implantation0.80983356
110MP0002877_abnormal_melanocyte_morpholog0.78657016
111MP0005666_abnormal_adipose_tissue0.78306683
112MP0002876_abnormal_thyroid_physiology0.76739944
113MP0009379_abnormal_foot_pigmentation0.76500556
114MP0008007_abnormal_cellular_replicative0.76367608
115MP0000470_abnormal_stomach_morphology0.75036354
116MP0004947_skin_inflammation0.74877148
117MP0005408_hypopigmentation0.73930023
118MP0004133_heterotaxia0.73529513
119MP0003115_abnormal_respiratory_system0.73196382
120MP0003638_abnormal_response/metabolism_0.73035255
121MP0000427_abnormal_hair_cycle0.71761061
122MP0002092_abnormal_eye_morphology0.70614549
123MP0002166_altered_tumor_susceptibility0.70053506
124MP0003195_calcinosis0.69392021
125MP0009931_abnormal_skin_appearance0.68840751
126MP0010094_abnormal_chromosome_stability0.68803187
127MP0005621_abnormal_cell_physiology0.66920856
128MP0001919_abnormal_reproductive_system0.65984616
129MP0005375_adipose_tissue_phenotype0.65269251
130MP0000003_abnormal_adipose_tissue0.64135449
131MP0000858_altered_metastatic_potential0.64092966
132MP0002136_abnormal_kidney_physiology0.62857192
133MP0003879_abnormal_hair_cell0.62327717
134MP0003329_amyloid_beta_deposits0.61848631
135MP0003786_premature_aging0.61132939
136MP0005187_abnormal_penis_morphology0.60342167
137MP0002909_abnormal_adrenal_gland0.59735266
138MP0000534_abnormal_ureter_morphology0.58734017
139MP0002089_abnormal_postnatal_growth/wei0.58429184

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)5.54316811
2Pili torti (HP:0003777)5.27388046
3Hyperactive renin-angiotensin system (HP:0000841)5.05952222
4Right ventricular cardiomyopathy (HP:0011663)5.03239140
5Micronodular cirrhosis (HP:0001413)4.50892326
6Fragile nails (HP:0001808)4.49787799
7Milia (HP:0001056)4.34491008
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.10599431
9Chronic bronchitis (HP:0004469)4.07371459
10Flat acetabular roof (HP:0003180)3.90178978
11Distal lower limb muscle weakness (HP:0009053)3.89439239
12Atrophic scars (HP:0001075)3.67663170
13Abnormality of the distal phalanges of the toes (HP:0010182)3.50991407
14Nail dystrophy (HP:0008404)3.41688545
15Trismus (HP:0000211)3.38359582
16Breast hypoplasia (HP:0003187)3.27609920
17Curly hair (HP:0002212)3.22650660
18Plantar hyperkeratosis (HP:0007556)3.12536591
19Biliary tract neoplasm (HP:0100574)3.11029713
20Abnormal respiratory motile cilium physiology (HP:0012261)3.08989099
21Rhinitis (HP:0012384)3.04242533
22Malnutrition (HP:0004395)3.03686750
23Abnormal respiratory motile cilium morphology (HP:0005938)2.99277776
24Abnormal respiratory epithelium morphology (HP:0012253)2.99277776
25Abnormality of glycolipid metabolism (HP:0010969)2.96893073
26Abnormality of liposaccharide metabolism (HP:0010968)2.96893073
27Abnormality of glycosphingolipid metabolism (HP:0004343)2.96893073
28Nasal polyposis (HP:0100582)2.91964832
29Woolly hair (HP:0002224)2.91889389
30Pustule (HP:0200039)2.88228551
31Abnormality of glutamine family amino acid metabolism (HP:0010902)2.85631566
32Carpal bone hypoplasia (HP:0001498)2.85348869
33Aplasia/hypoplasia of the humerus (HP:0006507)2.84705097
34Abnormality of monocarboxylic acid metabolism (HP:0010996)2.80835371
35Abnormal hair laboratory examination (HP:0003328)2.78072842
36Abnormality of renin-angiotensin system (HP:0000847)2.77328093
37Esophageal varix (HP:0002040)2.77207861
38Decreased circulating renin level (HP:0003351)2.76983545
39Alopecia of scalp (HP:0002293)2.76741624
40Abnormal ciliary motility (HP:0012262)2.75072460
41Abdominal distention (HP:0003270)2.74737597
42Abnormality of nail color (HP:0100643)2.72540917
43Cheilitis (HP:0100825)2.68836126
44Fused cervical vertebrae (HP:0002949)2.68217375
45Absent/shortened dynein arms (HP:0200106)2.67210689
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.67210689
47Gout (HP:0001997)2.66888790
48Abnormality of small intestinal villus morphology (HP:0011472)2.64466522
49Villous atrophy (HP:0011473)2.64466522
50J-shaped sella turcica (HP:0002680)2.62156983
51Septate vagina (HP:0001153)2.61175657
52Aplasia/hypoplasia of the uterus (HP:0008684)2.59798669
53Blepharitis (HP:0000498)2.56929295
54Abnormal blistering of the skin (HP:0008066)2.55934889
55Vascular calcification (HP:0004934)2.54778724
56Abnormality of the nasal mucosa (HP:0000433)2.52942599
57Bronchiectasis (HP:0002110)2.52234699
58Congenital ichthyosiform erythroderma (HP:0007431)2.51205268
59Rough bone trabeculation (HP:0100670)2.50983660
60Short humerus (HP:0005792)2.50811046
61Flattened epiphyses (HP:0003071)2.50397300
62Hypoplastic labia majora (HP:0000059)2.47366814
63Hypoplasia of dental enamel (HP:0006297)2.45953359
64Death in infancy (HP:0001522)2.43253043
65Acanthosis nigricans (HP:0000956)2.42251103
66Abnormal pancreas size (HP:0012094)2.41417991
67Distal lower limb amyotrophy (HP:0008944)2.40106803
68Thin bony cortex (HP:0002753)2.39216547
69Hyperparathyroidism (HP:0000843)2.38453838
70Abnormal biliary tract morphology (HP:0012440)2.37638307
71Spinal cord compression (HP:0002176)2.37036772
72Hyperacusis (HP:0010780)2.36927878
73Distal upper limb amyotrophy (HP:0007149)2.36786977
74Upper limb amyotrophy (HP:0009129)2.36786977
75Myopathic facies (HP:0002058)2.36187569
76Advanced eruption of teeth (HP:0006288)2.34861073
77Abnormality of chloride homeostasis (HP:0011422)2.34517212
78Pterygium (HP:0001059)2.34516924
79Mildly elevated creatine phosphokinase (HP:0008180)2.32486762
80Hypotrichosis (HP:0001006)2.32057310
81Malignant gastrointestinal tract tumors (HP:0006749)2.30346970
82Gastrointestinal carcinoma (HP:0002672)2.30346970
83Short nail (HP:0001799)2.30200700
84Ileus (HP:0002595)2.29984047
85Absent radius (HP:0003974)2.29882850
86Renal salt wasting (HP:0000127)2.29772198
87Popliteal pterygium (HP:0009756)2.29423091
88Hemorrhage of the eye (HP:0011885)2.29327900
89Aplasia involving forearm bones (HP:0009822)2.27013225
90Absent forearm bone (HP:0003953)2.27013225
91Broad face (HP:0000283)2.26782952
92Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.25754397
93Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.24824399
94Intrahepatic cholestasis (HP:0001406)2.23491633
95Cervical subluxation (HP:0003308)2.23068901
96Hyperaldosteronism (HP:0000859)2.19977447
97Selective tooth agenesis (HP:0001592)2.19290281
98Abnormality of the labia majora (HP:0012881)2.18905563
99Stenosis of the external auditory canal (HP:0000402)2.18004992
100Microretrognathia (HP:0000308)2.17787455
101Abnormality of the dental root (HP:0006486)2.15438462
102Taurodontia (HP:0000679)2.15438462
103Abnormality of permanent molar morphology (HP:0011071)2.15438462
104Esophageal atresia (HP:0002032)2.15142590
105Uterine neoplasm (HP:0010784)2.14144203
106Abnormality of proline metabolism (HP:0010907)2.14131366
107Hydroxyprolinuria (HP:0003080)2.14131366
108Hyperphosphatemia (HP:0002905)2.13842215
109Concave nail (HP:0001598)2.10991519
110Abnormality of the distal phalanx of the thumb (HP:0009617)2.10357676
111Sparse eyelashes (HP:0000653)2.10090553
112Fat malabsorption (HP:0002630)2.09377194
113Shawl scrotum (HP:0000049)2.08357218
114Hypoplasia of the uterus (HP:0000013)2.08185535
115Focal segmental glomerulosclerosis (HP:0000097)2.08145673
116Cardiovascular calcification (HP:0011915)2.07381061
117Cerebral hypomyelination (HP:0006808)2.06200876
118Abnormality of the gastric mucosa (HP:0004295)2.05318911
119Ependymoma (HP:0002888)2.05005696
120Stridor (HP:0010307)2.04934342
121Abnormal tarsal ossification (HP:0008369)2.03159788
122Unilateral renal agenesis (HP:0000122)2.02924902
123Germ cell neoplasia (HP:0100728)2.02187052
124Multiple enchondromatosis (HP:0005701)2.01093667
125Split foot (HP:0001839)1.98996357
126Abnormality of the anterior horn cell (HP:0006802)1.98823456
127Degeneration of anterior horn cells (HP:0002398)1.98823456
128Growth hormone excess (HP:0000845)1.97510820
129Progressive sensorineural hearing impairment (HP:0000408)1.97390887
130Interstitial pulmonary disease (HP:0006530)1.97037429
131Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.96916656
132Oral leukoplakia (HP:0002745)1.96709903
133Missing ribs (HP:0000921)1.95912201
134Hyperglycemia (HP:0003074)1.95418882
135Premature ovarian failure (HP:0008209)1.94668377
136Abnormality of molar morphology (HP:0011070)1.94603103
137Abnormality of molar (HP:0011077)1.94603103
138Prolonged neonatal jaundice (HP:0006579)1.94489128
139Fibular aplasia (HP:0002990)1.93545155
140Neoplasm of the pancreas (HP:0002894)1.92138457
141Bronchomalacia (HP:0002780)1.91659993
142Palmoplantar hyperkeratosis (HP:0000972)1.91613648
143Axonal loss (HP:0003447)1.91334613
144Diaphragmatic weakness (HP:0009113)1.90513615
145Spinal muscular atrophy (HP:0007269)1.90397473
146Abnormality of the umbilical cord (HP:0010881)1.90393557
147Dehydration (HP:0001944)1.90229531
148Difficulty climbing stairs (HP:0003551)1.90036693
149Progressive muscle weakness (HP:0003323)1.89383702
150Hyponatremia (HP:0002902)1.88277373
151Tongue fasciculations (HP:0001308)1.87636388
152Abnormality of the dental pulp (HP:0006479)1.86564427
153Abnormality of carpal bone ossification (HP:0006257)1.86504467
15411 pairs of ribs (HP:0000878)1.84857755
155Abnormality of the salivary glands (HP:0010286)1.84455982
156Alkalosis (HP:0001948)1.83805438
157Sparse lateral eyebrow (HP:0005338)1.81878640
158Muscle fibrillation (HP:0010546)1.81300418
159Flat capital femoral epiphysis (HP:0003370)1.80962335
160Subcapsular cataract (HP:0000523)1.80533436
161Amelogenesis imperfecta (HP:0000705)1.78698922
162Ureteral duplication (HP:0000073)1.78287311
163Glomerulosclerosis (HP:0000096)1.78042454
164Colon cancer (HP:0003003)1.77939953
165Congenital, generalized hypertrichosis (HP:0004540)1.77246887
166Lip pit (HP:0100267)1.77124751
167Abnormal trabecular bone morphology (HP:0100671)1.76678089
168Vertebral hypoplasia (HP:0008417)1.74521959
169Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.74521959
170Breast carcinoma (HP:0003002)1.73692634
171Abnormality of the labia (HP:0000058)1.71745683
172Anonychia (HP:0001798)1.71017982

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* EPHA25.72029180
2RPS6KB24.13412723
3BUB14.03645255
4SIK13.49524152
5AKT33.36058736
6WEE13.34437469
7LMTK23.29180488
8MST42.97062932
9TSSK62.38624447
10MAP2K22.27748749
11SMG12.26996075
12PAK42.22136966
13FER2.18137686
14PKN22.18014032
15MAP3K32.13441988
16NME11.88260489
17PTK21.84786139
18PRKCI1.83155668
19TTK1.79981944
20LATS11.61546865
21MAP3K121.58780160
22TESK11.58446186
23MAPK151.52536904
24NEK11.50503257
25MAP3K21.48685957
26PNCK1.41743971
27FRK1.39944504
28STK38L1.39781808
29STK391.38331415
30SCYL21.35353640
31PLK41.34695086
32ICK1.29342557
33MET1.28635751
34MAPKAPK31.28464715
35ZAK1.28193430
36STK101.22634204
37MST1R1.22204771
38BRSK21.19112638
39DYRK31.18720951
40IRAK31.17929262
41PIK3CA1.13137246
42MAP3K81.09846290
43PTK61.07930141
44EPHB11.05834708
45NEK61.05389957
46CDK121.04793845
47LRRK21.04689828
48EIF2AK31.00752081
49AURKB0.98953354
50NEK20.95195462
51MAP3K90.92790208
52PASK0.92267317
53EPHA30.92241568
54EPHB20.91207859
55MUSK0.89938805
56MAP2K10.86999513
57STK240.85728098
58PLK10.84984390
59AURKA0.83274639
60EEF2K0.80209213
61ILK0.78116577
62ERN10.76086031
63STK380.74686503
64STK160.72560867
65TBK10.71524367
66MTOR0.71500975
67PLK30.68487272
68PAK10.68036164
69STK30.67955295
70TAOK10.67768532
71TESK20.65730527
72MAP3K110.65412301
73RIPK10.64360977
74CDK70.64357926
75TRIB30.63127986
76EIF2AK10.61793687
77PRKD20.60164892
78PDK20.58934201
79MAP2K60.58810405
80PIM20.58519723
81CAMK2B0.58472305
82MYLK0.58254165
83MAP3K10.56271555
84RPS6KA40.55405223
85NEK90.55040217
86SIK30.54922620
87FGFR40.54796460
88RPS6KA20.54625015
89DDR20.54395558
90DMPK0.53657138
91HIPK20.52799876
92CAMK2G0.51821456
93SRPK10.51093817
94PDK30.49733720
95PDK40.49733720
96OXSR10.49125676
97CSNK1E0.47966136
98PAK30.47943731
99LATS20.47938613
100CAMK2D0.47565570
101ABL20.47512909
102VRK20.47326896
103PDPK10.47211011
104NME20.46773225
105BCR0.46485853
106CHUK0.46027186
107ALK0.44872116
108MELK0.43790230
109CHEK20.43515196
110DAPK10.42853341
111MAPKAPK20.39906457
112ERBB20.39614073
113PRKG20.36689142
114RET0.36645962
115CDC42BPA0.35323122
116CHEK10.34893254
117GRK60.34799079
118PBK0.34287624
119ACVR1B0.33862082
120KDR0.32922543
121MAP3K100.32902950
122MATK0.32004654
123WNK40.31329328
124CDK60.31029580
125BRSK10.30948675
126TAOK20.30656129
127MAP3K60.29751932
128AKT20.28913018
129IRAK10.28286656
130TTN0.28107788
131PRKAA20.26297945
132MARK20.26139797
133IRAK20.26064445
134LIMK10.26061497
135BRAF0.24838514
136PRKD10.24390597
137BMX0.23913969
138PHKG20.23781732
139PHKG10.23781732
140DYRK1B0.22977767
141CDK20.22260817
142PDGFRA0.20191980
143ARAF0.20084270
144SRC0.18344322
145IKBKB0.18009235
146CSNK1A10.17453980
147RPS6KC10.17077146

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.26619035
2Proteasome_Homo sapiens_hsa030503.61056466
3Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.64657214
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.44711170
5* Tight junction_Homo sapiens_hsa045302.38598010
6RNA transport_Homo sapiens_hsa030132.33389327
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32358818
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.31676971
9Hippo signaling pathway_Homo sapiens_hsa043902.23991884
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19913039
11Ribosome_Homo sapiens_hsa030102.09025667
12Fructose and mannose metabolism_Homo sapiens_hsa000512.07265309
13Adherens junction_Homo sapiens_hsa045202.05654098
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.02668101
15Folate biosynthesis_Homo sapiens_hsa007901.95099865
16p53 signaling pathway_Homo sapiens_hsa041151.83854117
17Chemical carcinogenesis_Homo sapiens_hsa052041.83389508
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.81425492
19RNA polymerase_Homo sapiens_hsa030201.78528965
20Bladder cancer_Homo sapiens_hsa052191.70262571
21Regulation of autophagy_Homo sapiens_hsa041401.68887784
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67617459
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.63634410
24Vitamin B6 metabolism_Homo sapiens_hsa007501.63621984
25Tyrosine metabolism_Homo sapiens_hsa003501.62959201
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.61444113
27Small cell lung cancer_Homo sapiens_hsa052221.57235292
28Caffeine metabolism_Homo sapiens_hsa002321.54721405
29Arginine biosynthesis_Homo sapiens_hsa002201.52026979
30Hedgehog signaling pathway_Homo sapiens_hsa043401.49413826
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49282736
32Spliceosome_Homo sapiens_hsa030401.47014425
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46439656
34Cell cycle_Homo sapiens_hsa041101.41791888
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.41656981
36Sulfur relay system_Homo sapiens_hsa041221.41457601
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41394477
38Galactose metabolism_Homo sapiens_hsa000521.41170581
39Starch and sucrose metabolism_Homo sapiens_hsa005001.40603935
40Pentose phosphate pathway_Homo sapiens_hsa000301.39935985
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39746943
42Fat digestion and absorption_Homo sapiens_hsa049751.37372409
43Basal cell carcinoma_Homo sapiens_hsa052171.36958602
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36436440
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35001775
46Thyroid cancer_Homo sapiens_hsa052161.33992338
47Pancreatic secretion_Homo sapiens_hsa049721.33773045
48Renin-angiotensin system_Homo sapiens_hsa046141.32508346
49Glutathione metabolism_Homo sapiens_hsa004801.28695893
50* Hepatitis C_Homo sapiens_hsa051601.27524692
51ECM-receptor interaction_Homo sapiens_hsa045121.26260362
52Retinol metabolism_Homo sapiens_hsa008301.24542481
53Mineral absorption_Homo sapiens_hsa049781.24283407
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23623268
55DNA replication_Homo sapiens_hsa030301.22274221
56Arachidonic acid metabolism_Homo sapiens_hsa005901.21922148
57Mismatch repair_Homo sapiens_hsa034301.20545883
58Notch signaling pathway_Homo sapiens_hsa043301.19717956
59Bile secretion_Homo sapiens_hsa049761.17289933
60Lysosome_Homo sapiens_hsa041421.15676395
61Vibrio cholerae infection_Homo sapiens_hsa051101.15489777
62Pyrimidine metabolism_Homo sapiens_hsa002401.14555774
63Vitamin digestion and absorption_Homo sapiens_hsa049771.10379644
64Glycerophospholipid metabolism_Homo sapiens_hsa005641.06602013
65Other glycan degradation_Homo sapiens_hsa005111.06536377
66Proteoglycans in cancer_Homo sapiens_hsa052051.05147248
67* Leukocyte transendothelial migration_Homo sapiens_hsa046701.04873223
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00774814
69Linoleic acid metabolism_Homo sapiens_hsa005910.99262750
70PPAR signaling pathway_Homo sapiens_hsa033200.97678345
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94663633
72Insulin resistance_Homo sapiens_hsa049310.92891184
73Selenocompound metabolism_Homo sapiens_hsa004500.92739295
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86943207
75Base excision repair_Homo sapiens_hsa034100.86134631
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84936509
77Epstein-Barr virus infection_Homo sapiens_hsa051690.83995513
78Shigellosis_Homo sapiens_hsa051310.83715603
79Nucleotide excision repair_Homo sapiens_hsa034200.82731661
80Antigen processing and presentation_Homo sapiens_hsa046120.81227768
81MicroRNAs in cancer_Homo sapiens_hsa052060.79680967
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79341187
83One carbon pool by folate_Homo sapiens_hsa006700.79015555
84beta-Alanine metabolism_Homo sapiens_hsa004100.78828244
85Fatty acid degradation_Homo sapiens_hsa000710.77171521
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.77025864
87Focal adhesion_Homo sapiens_hsa045100.73428999
88Sphingolipid metabolism_Homo sapiens_hsa006000.73003773
89mTOR signaling pathway_Homo sapiens_hsa041500.72806748
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72535547
91AMPK signaling pathway_Homo sapiens_hsa041520.71248373
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.70478149
93Fatty acid biosynthesis_Homo sapiens_hsa000610.69108543
94Protein export_Homo sapiens_hsa030600.68606835
95Viral carcinogenesis_Homo sapiens_hsa052030.68544913
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67482566
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66768046
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65445217
99Pathways in cancer_Homo sapiens_hsa052000.64868643
100Thyroid hormone synthesis_Homo sapiens_hsa049180.64176626
101Legionellosis_Homo sapiens_hsa051340.63721411
102Histidine metabolism_Homo sapiens_hsa003400.63692833
103Endocytosis_Homo sapiens_hsa041440.63461345
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63306211
105ABC transporters_Homo sapiens_hsa020100.62257543
106Wnt signaling pathway_Homo sapiens_hsa043100.62110680
107Nitrogen metabolism_Homo sapiens_hsa009100.61378867
108Insulin signaling pathway_Homo sapiens_hsa049100.60881999
109HTLV-I infection_Homo sapiens_hsa051660.60664438
110Amoebiasis_Homo sapiens_hsa051460.60226119
111Glycerolipid metabolism_Homo sapiens_hsa005610.59576481
112Oocyte meiosis_Homo sapiens_hsa041140.59102830
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57326044
114TGF-beta signaling pathway_Homo sapiens_hsa043500.57073298
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56159290
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53081033
117N-Glycan biosynthesis_Homo sapiens_hsa005100.52858851
118mRNA surveillance pathway_Homo sapiens_hsa030150.52711394
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51786609
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.51594940
121Fatty acid elongation_Homo sapiens_hsa000620.51500010
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51287699
123Endometrial cancer_Homo sapiens_hsa052130.51187415
124Biosynthesis of amino acids_Homo sapiens_hsa012300.51142459
125Homologous recombination_Homo sapiens_hsa034400.50550755
126Apoptosis_Homo sapiens_hsa042100.49612679
127Tryptophan metabolism_Homo sapiens_hsa003800.49525579
128ErbB signaling pathway_Homo sapiens_hsa040120.47673201
129Acute myeloid leukemia_Homo sapiens_hsa052210.47660540
130Arginine and proline metabolism_Homo sapiens_hsa003300.47652055
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.47571346
132Sulfur metabolism_Homo sapiens_hsa009200.47551138
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47332548
134Circadian rhythm_Homo sapiens_hsa047100.47254681
135Renal cell carcinoma_Homo sapiens_hsa052110.46806661
136Choline metabolism in cancer_Homo sapiens_hsa052310.44928673
137Inositol phosphate metabolism_Homo sapiens_hsa005620.44851158
138Carbon metabolism_Homo sapiens_hsa012000.44585117
139Phenylalanine metabolism_Homo sapiens_hsa003600.43208711
140Prostate cancer_Homo sapiens_hsa052150.42998351
141VEGF signaling pathway_Homo sapiens_hsa043700.42897200
142Protein digestion and absorption_Homo sapiens_hsa049740.41868260
143Axon guidance_Homo sapiens_hsa043600.40598346
144HIF-1 signaling pathway_Homo sapiens_hsa040660.38165031
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38138341
146Chronic myeloid leukemia_Homo sapiens_hsa052200.38073161
147Fatty acid metabolism_Homo sapiens_hsa012120.37367663
148Purine metabolism_Homo sapiens_hsa002300.37068242
149Ovarian steroidogenesis_Homo sapiens_hsa049130.35511014
150Glucagon signaling pathway_Homo sapiens_hsa049220.34461727
151Basal transcription factors_Homo sapiens_hsa030220.33733207

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