CLDN7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal epithelial cell development (GO:0060576)7.88447866
2intestinal absorption (GO:0050892)6.70787907
3bundle of His cell to Purkinje myocyte communication (GO:0086069)5.96133781
43-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.59291918
5purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.59291918
6NADH metabolic process (GO:0006734)5.56223301
7negative regulation of keratinocyte proliferation (GO:0010839)5.31769014
8intestinal cholesterol absorption (GO:0030299)5.21004016
9maintenance of gastrointestinal epithelium (GO:0030277)5.09353611
10flavonoid metabolic process (GO:0009812)5.07474610
11hepatocyte apoptotic process (GO:0097284)5.04617192
12bile acid and bile salt transport (GO:0015721)4.98525813
13UDP-N-acetylglucosamine metabolic process (GO:0006047)4.96380013
14sulfate transmembrane transport (GO:1902358)4.87031352
15GDP-mannose metabolic process (GO:0019673)4.86381273
16regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.83371713
17* calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.56853899
18regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.51221787
19pyrimidine-containing compound transmembrane transport (GO:0072531)4.42241151
20interferon-gamma secretion (GO:0072643)4.30422719
21regulation of guanylate cyclase activity (GO:0031282)4.27757423
22sulfate transport (GO:0008272)4.22716292
23nucleotide-sugar biosynthetic process (GO:0009226)4.20790430
24digestive system process (GO:0022600)4.18438770
25galactose catabolic process (GO:0019388)4.15433997
26epoxygenase P450 pathway (GO:0019373)4.13914940
27regulation of water loss via skin (GO:0033561)4.10321051
28desmosome organization (GO:0002934)4.05866899
29positive regulation of epidermal cell differentiation (GO:0045606)4.02554272
30sulfation (GO:0051923)3.99495703
31sulfur compound transport (GO:0072348)3.98513976
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.92424866
33tight junction assembly (GO:0070830)3.88987944
34keratinocyte development (GO:0003334)3.87999153
35cellular glucuronidation (GO:0052695)3.85838591
36angiotensin maturation (GO:0002003)3.85091010
37epithelial structure maintenance (GO:0010669)3.84537889
38uronic acid metabolic process (GO:0006063)3.83396456
39glucuronate metabolic process (GO:0019585)3.83396456
40regulation of respiratory burst (GO:0060263)3.83346966
41urea cycle (GO:0000050)3.79717545
42renal system process involved in regulation of blood volume (GO:0001977)3.71727156
43fructose metabolic process (GO:0006000)3.69338945
44positive regulation of respiratory burst (GO:0060267)3.63319292
45antibacterial humoral response (GO:0019731)3.60474114
46sphingomyelin metabolic process (GO:0006684)3.59090833
47regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.58442486
48endocrine process (GO:0050886)3.58442486
49regulation of systemic arterial blood pressure by hormone (GO:0001990)3.58442486
50cell differentiation involved in embryonic placenta development (GO:0060706)3.54949568
51glandular epithelial cell differentiation (GO:0002067)3.54648177
52establishment of skin barrier (GO:0061436)3.54610633
53antimicrobial humoral response (GO:0019730)3.52951444
54urea metabolic process (GO:0019627)3.51630960
55phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.51068166
56vitamin transmembrane transport (GO:0035461)3.50918548
57modified amino acid transport (GO:0072337)3.50310936
58diol metabolic process (GO:0034311)3.49957672
59glutathione biosynthetic process (GO:0006750)3.49037339
60oligosaccharide biosynthetic process (GO:0009312)3.46752725
61O-glycan processing (GO:0016266)3.44579969
62ventricular cardiac muscle cell action potential (GO:0086005)3.43049365
63phosphatidylserine acyl-chain remodeling (GO:0036150)3.43019698
64actin filament depolymerization (GO:0030042)3.39365745
65sulfur amino acid catabolic process (GO:0000098)3.38343342
66ATP synthesis coupled proton transport (GO:0015986)3.38189179
67energy coupled proton transport, down electrochemical gradient (GO:0015985)3.38189179
68fat-soluble vitamin biosynthetic process (GO:0042362)3.37928538
69negative regulation of protein tyrosine kinase activity (GO:0061099)3.37652929
70water homeostasis (GO:0030104)3.36406456
71regulation of cellular extravasation (GO:0002691)3.35988418
72oxidative phosphorylation (GO:0006119)3.35696962
73negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.33492510
74regulation of systemic arterial blood pressure (GO:0003073)3.32697426
75endocrine pancreas development (GO:0031018)3.31684761
76positive regulation of Cdc42 GTPase activity (GO:0043089)3.30831388
77regulation of hydrogen peroxide metabolic process (GO:0010310)3.30325698
78trophectodermal cell differentiation (GO:0001829)3.28829429
79regulation of keratinocyte proliferation (GO:0010837)3.27662818
80nonribosomal peptide biosynthetic process (GO:0019184)3.25108623
81glutamine family amino acid biosynthetic process (GO:0009084)3.24166595
82lung secretory cell differentiation (GO:0061140)3.20466789
83hemidesmosome assembly (GO:0031581)3.20258738
84ethanol oxidation (GO:0006069)3.19530782
85gap junction assembly (GO:0016264)3.18976018
86columnar/cuboidal epithelial cell development (GO:0002066)3.16735011
87epithelial cell-cell adhesion (GO:0090136)3.16515919
88bicarbonate transport (GO:0015701)3.14096313
89positive regulation of pseudopodium assembly (GO:0031274)3.14042810
90cytidine deamination (GO:0009972)3.12954244
91cytidine metabolic process (GO:0046087)3.12954244
92cytidine catabolic process (GO:0006216)3.12954244
93negative regulation of T cell differentiation in thymus (GO:0033085)3.12654999
94nitrogen cycle metabolic process (GO:0071941)3.11861280
95regulation of cholesterol homeostasis (GO:2000188)3.10647172
96transcytosis (GO:0045056)3.09834262
97positive regulation of epidermis development (GO:0045684)3.08762656
98drug metabolic process (GO:0017144)3.06397062
99nucleotide-sugar metabolic process (GO:0009225)3.04758803
100hormone catabolic process (GO:0042447)3.04641979
101renal filtration (GO:0097205)3.04411635
102regulation of vitamin metabolic process (GO:0030656)3.04058837
103peptide catabolic process (GO:0043171)3.03691352
104COPI coating of Golgi vesicle (GO:0048205)3.03290349
105Golgi transport vesicle coating (GO:0048200)3.03290349
106phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.02240218
107multicellular organismal water homeostasis (GO:0050891)3.01883404
108branching involved in mammary gland duct morphogenesis (GO:0060444)3.01423826
109positive regulation of guanylate cyclase activity (GO:0031284)3.00566803
110positive regulation of glycoprotein biosynthetic process (GO:0010560)2.99296046
111primary alcohol catabolic process (GO:0034310)2.99206655
112glomerular filtration (GO:0003094)2.96623244
113vitamin A metabolic process (GO:0006776)2.96584707
114phosphatidylserine metabolic process (GO:0006658)2.96489903
115regulation of keratinocyte differentiation (GO:0045616)2.96021341
116nucleoside diphosphate biosynthetic process (GO:0009133)2.95934226
117positive regulation of T cell differentiation in thymus (GO:0033089)2.95499964
118auditory receptor cell differentiation (GO:0042491)2.94993381
119protein retention in ER lumen (GO:0006621)2.94080198
120regulation of chemokine secretion (GO:0090196)2.93182633
121ethanol metabolic process (GO:0006067)2.93149573
122regulation of cGMP biosynthetic process (GO:0030826)2.90642983
123signal transduction involved in regulation of gene expression (GO:0023019)2.89579613
124nucleoside bisphosphate metabolic process (GO:0033865)2.88884380
125purine nucleoside bisphosphate metabolic process (GO:0034032)2.88884380
126ribonucleoside bisphosphate metabolic process (GO:0033875)2.88884380
127diterpenoid biosynthetic process (GO:0016102)2.87031503
128digestion (GO:0007586)2.86573022
129negative regulation of epidermal cell differentiation (GO:0045605)2.86443267
130regulation of bile acid biosynthetic process (GO:0070857)2.86095555
131vitamin transport (GO:0051180)2.85599893
132maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.85198500
133glycolipid catabolic process (GO:0019377)2.82954148
134proline biosynthetic process (GO:0006561)2.82425251
135regulation of viral release from host cell (GO:1902186)2.82406593
136renal absorption (GO:0070293)2.82044475
137regulation of early endosome to late endosome transport (GO:2000641)2.79142628
138proline metabolic process (GO:0006560)2.78763252
139homocysteine metabolic process (GO:0050667)2.78561059
140positive regulation of glycoprotein metabolic process (GO:1903020)2.78532037
141regulation of pseudopodium assembly (GO:0031272)2.77067419
142alditol phosphate metabolic process (GO:0052646)2.76907822
143purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.74389678
144ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.74389678
145nucleoside bisphosphate biosynthetic process (GO:0033866)2.74389678
146fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.72428598
147excretion (GO:0007588)2.71572901
148receptor guanylyl cyclase signaling pathway (GO:0007168)2.71220037
149glucose 6-phosphate metabolic process (GO:0051156)2.69727265
150amyloid precursor protein catabolic process (GO:0042987)2.67687436
151peptide hormone processing (GO:0016486)2.67550100
152glycosphingolipid catabolic process (GO:0046479)2.62572110
153cell-cell junction assembly (GO:0007043)2.61924133
154glutathione metabolic process (GO:0006749)2.61885746

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.81929137
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.02529180
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.48363680
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.03766255
5GATA4_25053715_ChIP-Seq_YYC3_Human2.82623847
6HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.78038488
7* GATA6_25053715_ChIP-Seq_YYC3_Human2.71852415
8SRY_22984422_ChIP-ChIP_TESTIS_Rat2.55902609
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.49181846
10* SOX2_20726797_ChIP-Seq_SW620_Human2.42649588
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.31541185
12NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.26241930
13* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.24345952
14AR_21909140_ChIP-Seq_LNCAP_Human2.21513373
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18671429
16ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.18389746
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.16636297
18* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.10761962
19SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.03719135
20PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03634511
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.02823792
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.99822557
23ZNF263_19887448_ChIP-Seq_K562_Human1.89036798
24RACK7_27058665_Chip-Seq_MCF-7_Human1.86172631
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.76862969
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76711448
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.76478616
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.73894025
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73842944
30* ATF3_27146783_Chip-Seq_COLON_Human1.73700787
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.73483295
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69957240
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67696729
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.66777361
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.65850208
36RUNX1_27514584_Chip-Seq_MCF-7_Human1.64492219
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63223281
38BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.61311539
39TCF3_18692474_ChIP-Seq_MEFs_Mouse1.55597453
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55349580
41OCT4_18692474_ChIP-Seq_MEFs_Mouse1.54953903
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.50849174
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.41858899
44PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35433843
45* KLF5_25053715_ChIP-Seq_YYC3_Human1.35123384
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.34612463
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34221755
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.32874682
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32098345
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31962004
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30759603
52* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.29547428
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29021109
54GATA3_24758297_ChIP-Seq_MCF-7_Human1.27246471
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27164923
56NANOG_18692474_ChIP-Seq_MEFs_Mouse1.25513689
57* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25221804
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.24363225
59PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21535212
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.20998096
61SOX2_18692474_ChIP-Seq_MEFs_Mouse1.20928811
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19916854
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19865407
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15074249
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12565550
66* CHD1_26751641_Chip-Seq_LNCaP_Human1.12431300
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.10155318
68FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09754245
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09270860
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09268398
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09160421
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09040122
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08993302
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07547935
75* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06580816
76* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06580816
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06045117
78* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05695436
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04975318
80MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04934180
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04780182
82* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04464888
83LXR_22158963_ChIP-Seq_LIVER_Mouse1.03569585
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03370361
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03005751
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02681989
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02447322
88* PHF8_20622854_ChIP-Seq_HELA_Human1.02119700
89FOXA1_25552417_ChIP-Seq_VCAP_Human1.00609847
90CLOCK_20551151_ChIP-Seq_293T_Human0.99891578
91NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99123492
92ELF5_23300383_ChIP-Seq_T47D_Human0.98742924
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97023052
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96746468
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.96194855
96KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96032489
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95656208
98SA1_27219007_Chip-Seq_Bcells_Human0.95649718
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95617730
100* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95159173
101* SMC4_20622854_ChIP-Seq_HELA_Human0.92854930
102BCOR_27268052_Chip-Seq_Bcells_Human0.92567070
103IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92495669
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92461830
105LXR_22292898_ChIP-Seq_THP-1_Human0.92307673
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92158551
107SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91248413
108CTCF_27219007_Chip-Seq_Bcells_Human0.91075205
109* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90908887
110CREB1_26743006_Chip-Seq_LNCaP_Human0.90729458
111JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.90258227
112RARA_24833708_ChIP-Seq_LIVER_Mouse0.87086879
113TP63_22573176_ChIP-Seq_HFKS_Human0.87082273
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.86974917
115TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.86642285
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86628261
117* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86163979
118SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86002912
119ETS1_20019798_ChIP-Seq_JURKAT_Human0.85952743
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85777527
121* ERG_21242973_ChIP-ChIP_JURKAT_Human0.85490115
122CTCF_20526341_ChIP-Seq_ESCs_Human0.85257677
123GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83904083
124* SA1_27219007_Chip-Seq_ERYTHROID_Human0.83779964
125SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83620481
126POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.83134356
127JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.82494378
128P68_20966046_ChIP-Seq_HELA_Human0.81169556
129TCF3_18692474_ChIP-Seq_MESCs_Mouse0.80936697
130NANOG_18692474_ChIP-Seq_MESCs_Mouse0.80464802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.68428249
2MP0004264_abnormal_extraembryonic_tissu4.41076594
3MP0003283_abnormal_digestive_organ4.08074136
4MP0005377_hearing/vestibular/ear_phenot4.02876271
5MP0003878_abnormal_ear_physiology4.02876271
6MP0001666_abnormal_nutrient_absorption3.78277287
7MP0000462_abnormal_digestive_system3.77920550
8MP0005360_urolithiasis3.42603985
9MP0003866_abnormal_defecation3.22910469
10MP0003693_abnormal_embryo_hatching2.96462167
11MP0000537_abnormal_urethra_morphology2.71438526
12MP0000490_abnormal_crypts_of2.59415526
13MP0010352_gastrointestinal_tract_polyps2.55197445
14MP0002822_catalepsy2.51188665
15MP0001873_stomach_inflammation2.24465935
16MP0010155_abnormal_intestine_physiology2.20945709
17MP0005381_digestive/alimentary_phenotyp2.18504973
18MP0000477_abnormal_intestine_morphology2.12903010
19MP0001663_abnormal_digestive_system2.12353527
20MP0003315_abnormal_perineum_morphology2.08500410
21MP0004019_abnormal_vitamin_homeostasis2.03347132
22MP0000566_synostosis1.99233049
23MP0009840_abnormal_foam_cell1.93292357
24MP0004858_abnormal_nervous_system1.93206342
25MP0005085_abnormal_gallbladder_physiolo1.90950388
26MP0004043_abnormal_pH_regulation1.90081796
27MP0002796_impaired_skin_barrier1.78666768
28MP0008875_abnormal_xenobiotic_pharmacok1.73857293
29MP0003300_gastrointestinal_ulcer1.73107400
30MP0001664_abnormal_digestion1.70312186
31MP0001849_ear_inflammation1.68787343
32MP0002139_abnormal_hepatobiliary_system1.62390821
33MP0010678_abnormal_skin_adnexa1.56785563
34MP0005451_abnormal_body_composition1.54537547
35MP0004957_abnormal_blastocyst_morpholog1.51752151
36MP0009780_abnormal_chondrocyte_physiolo1.50457740
37MP0002098_abnormal_vibrissa_morphology1.50361189
38* MP0009643_abnormal_urine_homeostasis1.45835582
39MP0005409_darkened_coat_color1.45517044
40MP0003806_abnormal_nucleotide_metabolis1.43096046
41MP0004147_increased_porphyrin_level1.35316552
42MP0000678_abnormal_parathyroid_gland1.31093941
43MP0005083_abnormal_biliary_tract1.30565221
44MP0004782_abnormal_surfactant_physiolog1.30457415
45MP0005084_abnormal_gallbladder_morpholo1.28672622
46MP0001765_abnormal_ion_homeostasis1.26069731
47MP0003941_abnormal_skin_development1.22050997
48MP0000538_abnormal_urinary_bladder1.19921054
49MP0001756_abnormal_urination1.19522221
50MP0005167_abnormal_blood-brain_barrier1.19015859
51MP0008004_abnormal_stomach_pH1.15788115
52MP0003252_abnormal_bile_duct1.15273665
53MP0009379_abnormal_foot_pigmentation1.14748030
54MP0005166_decreased_susceptibility_to1.13925483
55MP0000579_abnormal_nail_morphology1.13700660
56MP0009053_abnormal_anal_canal1.11937825
57MP0003879_abnormal_hair_cell1.09902418
58MP0003705_abnormal_hypodermis_morpholog1.06142802
59MP0002234_abnormal_pharynx_morphology1.05130527
60MP0000613_abnormal_salivary_gland1.03413832
61MP0000470_abnormal_stomach_morphology1.02904126
62MP0005365_abnormal_bile_salt1.02565065
63MP0005501_abnormal_skin_physiology1.01171169
64MP0003868_abnormal_feces_composition1.00823539
65MP0005636_abnormal_mineral_homeostasis0.99690886
66MP0003453_abnormal_keratinocyte_physiol0.97646319
67MP0005310_abnormal_salivary_gland0.96182512
68MP0001216_abnormal_epidermal_layer0.95726225
69MP0002277_abnormal_respiratory_mucosa0.93817485
70MP0006054_spinal_hemorrhage0.92077883
71MP0010771_integument_phenotype0.91764386
72MP0001485_abnormal_pinna_reflex0.91533169
73MP0000467_abnormal_esophagus_morphology0.90222221
74MP0010329_abnormal_lipoprotein_level0.86983288
75MP0001764_abnormal_homeostasis0.86361139
76MP0005670_abnormal_white_adipose0.84245090
77MP0003191_abnormal_cellular_cholesterol0.83549046
78MP0004185_abnormal_adipocyte_glucose0.82709094
79MP0003119_abnormal_digestive_system0.82685864
80MP0004947_skin_inflammation0.81654286
81MP0003718_maternal_effect0.81530633
82MP0005165_increased_susceptibility_to0.81285793
83MP0002138_abnormal_hepatobiliary_system0.80084470
84MP0005023_abnormal_wound_healing0.78777540
85MP0002876_abnormal_thyroid_physiology0.76884354
86MP0001730_embryonic_growth_arrest0.76839426
87MP0005666_abnormal_adipose_tissue0.76315644
88MP0010030_abnormal_orbit_morphology0.76043832
89MP0005220_abnormal_exocrine_pancreas0.76028635
90MP0000516_abnormal_urinary_system0.75788996
91MP0005367_renal/urinary_system_phenotyp0.75788996
92MP0005058_abnormal_lysosome_morphology0.75130580
93MP0000762_abnormal_tongue_morphology0.72100010
94MP0000609_abnormal_liver_physiology0.69892208
95MP0002166_altered_tumor_susceptibility0.69818105
96MP0003183_abnormal_peptide_metabolism0.69081253
97MP0002254_reproductive_system_inflammat0.68955779
98MP0003123_paternal_imprinting0.68846521
99MP0003638_abnormal_response/metabolism_0.68759626
100MP0008872_abnormal_physiological_respon0.68598077
101MP0000681_abnormal_thyroid_gland0.67594017
102MP0000377_abnormal_hair_follicle0.67486523
103MP0003566_abnormal_cell_adhesion0.67157978
104MP0001944_abnormal_pancreas_morphology0.66122376
105MP0005332_abnormal_amino_acid0.64253480
106MP0000013_abnormal_adipose_tissue0.64237585
107MP0000383_abnormal_hair_follicle0.63913151
108MP0002060_abnormal_skin_morphology0.63252920
109MP0005584_abnormal_enzyme/coenzyme_acti0.61582752
110* MP0002136_abnormal_kidney_physiology0.61344416
111MP0001188_hyperpigmentation0.61283307
112* MP0009931_abnormal_skin_appearance0.60037812
113MP0002909_abnormal_adrenal_gland0.59932808
114MP0004272_abnormal_basement_membrane0.59571266
115MP0000858_altered_metastatic_potential0.59229029
116MP0002006_tumorigenesis0.58161372
117MP0001881_abnormal_mammary_gland0.57379245
118MP0010386_abnormal_urinary_bladder0.55177984
119MP0002132_abnormal_respiratory_system0.52897721
120MP0005076_abnormal_cell_differentiation0.51925746
121MP0002693_abnormal_pancreas_physiology0.51584774
122MP0009384_cardiac_valve_regurgitation0.50857437
123MP0005319_abnormal_enzyme/_coenzyme0.49023723
124MP0002896_abnormal_bone_mineralization0.48552303
125MP0002118_abnormal_lipid_homeostasis0.48504064
126MP0000627_abnormal_mammary_gland0.47722014

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)5.69946956
2Right ventricular cardiomyopathy (HP:0011663)5.27735153
3Abdominal distention (HP:0003270)4.51900397
4Flat acetabular roof (HP:0003180)4.12571773
5Abnormality of small intestinal villus morphology (HP:0011472)3.98033891
6Villous atrophy (HP:0011473)3.98033891
7Hyperactive renin-angiotensin system (HP:0000841)3.91534940
8Chronic bronchitis (HP:0004469)3.89309176
9Micronodular cirrhosis (HP:0001413)3.83464907
10Abnormality of the 1st metacarpal (HP:0010009)3.66817548
11Pili torti (HP:0003777)3.62018486
12Pustule (HP:0200039)3.55840728
13Fat malabsorption (HP:0002630)3.53520428
14Ventricular fibrillation (HP:0001663)3.46773624
15Malnutrition (HP:0004395)3.35099984
16Cupped ribs (HP:0000887)3.25703438
17Congenital sensorineural hearing impairment (HP:0008527)3.24557662
18Symphalangism affecting the phalanges of the hand (HP:0009773)3.24542559
19Abnormal biliary tract morphology (HP:0012440)3.13438277
20Biliary tract neoplasm (HP:0100574)3.11894883
21Abnormality of chloride homeostasis (HP:0011422)3.03629585
22Alkalosis (HP:0001948)3.02327845
23Hyperphosphatemia (HP:0002905)2.96963709
24Fragile nails (HP:0001808)2.95119674
25Abnormality of the distal phalanx of the thumb (HP:0009617)2.88898729
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.87099433
27Abnormality of carpal bone ossification (HP:0006257)2.83335603
28Vascular calcification (HP:0004934)2.82979223
29Abnormality of the proximal phalanges of the hand (HP:0009834)2.81202396
30Abnormal tarsal ossification (HP:0008369)2.79445989
31Increased purine levels (HP:0004368)2.79276385
32Hyperuricemia (HP:0002149)2.79276385
33Intrahepatic cholestasis (HP:0001406)2.75597493
34Onycholysis (HP:0001806)2.75451158
35Posterior subcapsular cataract (HP:0007787)2.75401693
36Hyperaldosteronism (HP:0000859)2.73901226
37Palpitations (HP:0001962)2.70798707
38Steatorrhea (HP:0002570)2.65193297
39Abnormality of glutamine family amino acid metabolism (HP:0010902)2.63633853
40Focal segmental glomerulosclerosis (HP:0000097)2.62731596
41Cheilitis (HP:0100825)2.62298309
42Woolly hair (HP:0002224)2.59408766
43Renal tubular acidosis (HP:0001947)2.57973575
44Metabolic alkalosis (HP:0200114)2.55554736
45Chronic diarrhea (HP:0002028)2.51316176
46Flat capital femoral epiphysis (HP:0003370)2.50282882
47Abnormal pancreas size (HP:0012094)2.50067208
48Hyperparathyroidism (HP:0000843)2.49381259
49Late onset (HP:0003584)2.47453164
50Hyponatremia (HP:0002902)2.46087197
51Abnormality of urine glucose concentration (HP:0011016)2.44051550
52Glycosuria (HP:0003076)2.44051550
53Short phalanx of the thumb (HP:0009660)2.42296407
54Trismus (HP:0000211)2.41531804
55Hypotension (HP:0002615)2.41346829
56Hyperammonemia (HP:0001987)2.40884773
57Nasal polyposis (HP:0100582)2.40774773
58Abnormality of magnesium homeostasis (HP:0004921)2.39274266
59Symptomatic seizures (HP:0011145)2.39199489
60Esophageal varix (HP:0002040)2.36652117
61Syncope (HP:0001279)2.34382521
62Glomerulosclerosis (HP:0000096)2.34083916
63Conjugated hyperbilirubinemia (HP:0002908)2.32206566
64Confusion (HP:0001289)2.30840269
65Abnormality of the nasal mucosa (HP:0000433)2.30546855
66Cardiovascular calcification (HP:0011915)2.30257238
67Abnormal cartilage morphology (HP:0002763)2.29411681
68Hypoglycemic coma (HP:0001325)2.28279191
69Breast hypoplasia (HP:0003187)2.27753051
70Abnormality of the distal phalanges of the toes (HP:0010182)2.27108002
71Rhinitis (HP:0012384)2.26707301
72Flattened epiphyses (HP:0003071)2.25933205
73Bronchiectasis (HP:0002110)2.25840084
74Progressive sensorineural hearing impairment (HP:0000408)2.25548380
75Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.23284347
76Dehydration (HP:0001944)2.23097586
77Milia (HP:0001056)2.21675002
78Abnormality of purine metabolism (HP:0004352)2.19780258
79Neonatal short-limb short stature (HP:0008921)2.19567730
80Vertebral hypoplasia (HP:0008417)2.19541668
81Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.19541668
82Lip pit (HP:0100267)2.19272437
83Hypobetalipoproteinemia (HP:0003563)2.19096418
84Abnormality of renin-angiotensin system (HP:0000847)2.16593740
85Abnormality of the 2nd finger (HP:0004100)2.16361451
86Amelogenesis imperfecta (HP:0000705)2.15691410
87Systemic lupus erythematosus (HP:0002725)2.15176015
88Proximal tubulopathy (HP:0000114)2.15124835
89Curly hair (HP:0002212)2.15021089
90Gout (HP:0001997)2.14504961
91Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14215548
92Abnormality of the vitamin B12 metabolism (HP:0004341)2.13543380
93Dicarboxylic aciduria (HP:0003215)2.13373055
94Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13373055
95Neoplasm of the rectum (HP:0100743)2.12224285
96Abnormal respiratory motile cilium physiology (HP:0012261)2.10861215
97Abnormal hand bone ossification (HP:0010660)2.08720309
98Spinal cord compression (HP:0002176)2.08120934
99Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.07333420
100Thin bony cortex (HP:0002753)2.07140562
101Widely patent fontanelles and sutures (HP:0004492)2.06931424
102Renal salt wasting (HP:0000127)2.06801884
103Hemorrhage of the eye (HP:0011885)2.06638351
104Distal lower limb muscle weakness (HP:0009053)2.06624016
105Abnormality of vitamin B metabolism (HP:0004340)2.05065035
106Gastrointestinal dysmotility (HP:0002579)2.04638559
107Wide cranial sutures (HP:0010537)2.04315707
108Breech presentation (HP:0001623)2.04122188
109Popliteal pterygium (HP:0009756)2.02803221
110Rectal prolapse (HP:0002035)2.02104988
111Abnormality of nucleobase metabolism (HP:0010932)2.01416921
112Plantar hyperkeratosis (HP:0007556)2.01409565
113Abnormal foot bone ossification (HP:0010675)2.01233184
114Vacuolated lymphocytes (HP:0001922)2.01162966
115Abnormal respiratory epithelium morphology (HP:0012253)2.01066474
116Abnormal respiratory motile cilium morphology (HP:0005938)2.01066474
117Growth hormone excess (HP:0000845)2.00791246
118Abnormality of the gastric mucosa (HP:0004295)2.00501556
119Irregular epiphyses (HP:0010582)2.00321656
120Abnormal ossification of hand bones (HP:0005921)2.00161475
121Hyperglycinuria (HP:0003108)2.00080538
122Alopecia of scalp (HP:0002293)1.99979239
123Insulin resistance (HP:0000855)1.99787794
124Uterine neoplasm (HP:0010784)1.99287010
125Decreased circulating renin level (HP:0003351)1.99099000
126Abnormality of serine family amino acid metabolism (HP:0010894)1.98909767
127Abnormality of glycine metabolism (HP:0010895)1.98909767
128Myopathic facies (HP:0002058)1.98283600
129Nephrolithiasis (HP:0000787)1.98183118
130Abnormal vertebral ossification (HP:0100569)1.97872992
131Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95847106
132Abnormality of monocarboxylic acid metabolism (HP:0010996)1.94574329
133Pterygium (HP:0001059)1.93556240
134Microretrognathia (HP:0000308)1.92748530
135Vertebral clefting (HP:0008428)1.92662153
136Sparse eyelashes (HP:0000653)1.92643733
137Short middle phalanx of finger (HP:0005819)1.92082290
138Abnormality of proline metabolism (HP:0010907)1.91593304
139Hydroxyprolinuria (HP:0003080)1.91593304
140Hyperphosphaturia (HP:0003109)1.90850672
141Megaloblastic anemia (HP:0001889)1.90030095
142Neoplasm of the small intestine (HP:0100833)1.89735527
143Progressive hearing impairment (HP:0001730)1.89527669
144Hypophosphatemia (HP:0002148)1.89414846
145Abnormality of the dental root (HP:0006486)1.88755530
146Taurodontia (HP:0000679)1.88755530
147Abnormality of permanent molar morphology (HP:0011071)1.88755530
148Hyperglycemia (HP:0003074)1.87950413
149Hypoplasia of the uterus (HP:0000013)1.87081736
150Abnormality of vitamin metabolism (HP:0100508)1.86823444
151Congenital ichthyosiform erythroderma (HP:0007431)1.86600659
152Abnormal hair laboratory examination (HP:0003328)1.86519094
153Hyperkalemia (HP:0002153)1.85047611
154Renal tubular dysfunction (HP:0000124)1.84664522
155Abnormal glucose tolerance (HP:0001952)1.84532250
156Abnormal urine phosphate concentration (HP:0012599)1.82028006
157Hypoplasia of dental enamel (HP:0006297)1.81657576
158Abnormal ciliary motility (HP:0012262)1.79799094
159Xanthomatosis (HP:0000991)1.78706703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.85866001
2MST1R5.04561621
3MAP2K24.22816174
4FRK3.67293699
5PIK3CA3.67287597
6NEK13.58544198
7TAOK33.29329098
8NME13.15638494
9MST43.00119865
10LMTK22.82922854
11TRIB32.61241345
12SMG12.59762453
13MAP3K22.49518762
14EPHB22.19968857
15MET1.85731728
16PRKG21.76223755
17TESK11.75007312
18BUB11.69190822
19RPS6KB21.68583779
20SIK11.63743048
21RIPK11.60853830
22NEK21.52808591
23AKT31.47757408
24MAPKAPK31.46911428
25STK241.46411527
26PTK61.38777659
27PRKCI1.38519881
28MAP2K11.38343598
29FGFR41.35062373
30TTK1.32341720
31DDR21.32200146
32ERN11.30654278
33MAP2K61.25751496
34KSR21.24974497
35MAP3K81.23402103
36PAK41.23287484
37BRAF1.20503696
38PTK21.18459037
39VRK21.16573485
40TAOK11.14435706
41MAPK151.12981039
42MYLK1.09693955
43GRK61.03277845
44CAMK2D1.02334163
45MAP3K31.01503241
46AURKB1.00178500
47MAP3K110.99463241
48PKN20.95930198
49MATK0.92641058
50NME20.89940040
51WEE10.88038187
52OXSR10.87027801
53IRAK30.83479623
54FER0.79938695
55PIM20.79105227
56NUAK10.78970848
57MAP3K10.73937527
58TESK20.73667966
59ARAF0.73161404
60WNK40.71419398
61PLK40.68873787
62MAP3K120.68181103
63EEF2K0.67559709
64STK38L0.66420577
65NEK60.64973868
66PASK0.64449857
67ERBB20.63859177
68ABL20.62234073
69CAMK2B0.61137897
70CAMK2G0.60500265
71STK100.58744782
72BMX0.56499572
73PAK10.50827852
74DAPK10.50334777
75ZAK0.48920332
76PBK0.47703087
77EPHA30.46679097
78LATS10.40987024
79DMPK0.40217247
80LIMK10.39688861
81LATS20.35908221
82CDC42BPA0.35052348
83STK160.33900994
84SCYL20.33806171
85MUSK0.32713363
86LRRK20.31660002
87CDK70.30704283
88PLK10.29549591
89STK390.29439663
90GRK10.29426698
91RPS6KA20.28732092
92DYRK1B0.27597064
93PRKD20.27388329
94NLK0.27004268
95PDK20.26768823
96PRKAA20.26342920
97ACVR1B0.24504075
98CSNK1A10.24016670
99PDPK10.23913906
100MELK0.23446412
101EPHB10.22952574
102DAPK30.22255149
103SRC0.22194804
104STK30.22188488
105HIPK20.21889045
106MTOR0.21461345
107AURKA0.20720217
108CDK120.20235222
109TSSK60.20178956
110FGFR30.20112272
111CHUK0.19997512
112* PRKCA0.19352624
113AKT20.19192324
114MAP3K100.18513290
115CSK0.18015299
116ILK0.17650487
117DYRK30.16873209
118BCKDK0.16672089
119ERBB40.16491438
120MAP3K90.16337257
121KDR0.15896638
122TAF10.15846864
123PRKCD0.13598719
124TBK10.13558721
125MAPKAPK20.13534485
126EIF2AK10.13417192
127CSNK1E0.13238144
128EIF2AK30.12997943
129BRSK20.10640779
130ICK0.10437098
131CDK90.10300658

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.76371450
2Fat digestion and absorption_Homo sapiens_hsa049753.79442285
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.60067471
4Mineral absorption_Homo sapiens_hsa049783.55628938
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.15772443
6Arginine biosynthesis_Homo sapiens_hsa002202.67909532
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.65532270
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.44080803
9Fructose and mannose metabolism_Homo sapiens_hsa000512.42332248
10Folate biosynthesis_Homo sapiens_hsa007902.23397497
11Galactose metabolism_Homo sapiens_hsa000522.17070080
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.11270908
13Renin-angiotensin system_Homo sapiens_hsa046141.95929496
14Sulfur relay system_Homo sapiens_hsa041221.93656987
15Oxidative phosphorylation_Homo sapiens_hsa001901.91732799
16Phenylalanine metabolism_Homo sapiens_hsa003601.76692131
17Glutathione metabolism_Homo sapiens_hsa004801.75028723
18Histidine metabolism_Homo sapiens_hsa003401.72151125
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70842468
20Linoleic acid metabolism_Homo sapiens_hsa005911.69547062
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61840803
22Parkinsons disease_Homo sapiens_hsa050121.58870970
23Pentose phosphate pathway_Homo sapiens_hsa000301.58680759
24Vitamin digestion and absorption_Homo sapiens_hsa049771.53296362
25Bile secretion_Homo sapiens_hsa049761.48850934
26Ribosome_Homo sapiens_hsa030101.43499134
27* Tight junction_Homo sapiens_hsa045301.37692396
28Protein digestion and absorption_Homo sapiens_hsa049741.37688162
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32530892
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29363365
31Pancreatic secretion_Homo sapiens_hsa049721.26715691
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24834809
33Glycerolipid metabolism_Homo sapiens_hsa005611.23709515
34Arachidonic acid metabolism_Homo sapiens_hsa005901.21661148
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21623536
36Alzheimers disease_Homo sapiens_hsa050101.20845829
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20255497
38Tyrosine metabolism_Homo sapiens_hsa003501.16589673
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.15191226
40Huntingtons disease_Homo sapiens_hsa050161.10261899
41Proteasome_Homo sapiens_hsa030501.07274417
42Thyroid cancer_Homo sapiens_hsa052161.06079936
43Starch and sucrose metabolism_Homo sapiens_hsa005001.05934714
44Chemical carcinogenesis_Homo sapiens_hsa052041.05140741
45Bladder cancer_Homo sapiens_hsa052191.04920079
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01622228
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.97187007
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95305524
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95224709
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94317929
51Tryptophan metabolism_Homo sapiens_hsa003800.93666478
52Fatty acid degradation_Homo sapiens_hsa000710.93176934
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93082127
54Caffeine metabolism_Homo sapiens_hsa002320.92362012
55Sphingolipid metabolism_Homo sapiens_hsa006000.91225294
56Arginine and proline metabolism_Homo sapiens_hsa003300.87383522
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85458853
58Butanoate metabolism_Homo sapiens_hsa006500.82361591
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78324905
60Carbon metabolism_Homo sapiens_hsa012000.74987706
61Vibrio cholerae infection_Homo sapiens_hsa051100.72751947
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71064054
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69599184
64N-Glycan biosynthesis_Homo sapiens_hsa005100.69020466
65Fatty acid elongation_Homo sapiens_hsa000620.67066890
66Metabolic pathways_Homo sapiens_hsa011000.66187513
67Other glycan degradation_Homo sapiens_hsa005110.65787874
68Protein export_Homo sapiens_hsa030600.65560708
69Selenocompound metabolism_Homo sapiens_hsa004500.65341424
70Fatty acid metabolism_Homo sapiens_hsa012120.65029919
71Thyroid hormone synthesis_Homo sapiens_hsa049180.64882848
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64868677
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.63197172
74Pyrimidine metabolism_Homo sapiens_hsa002400.59671025
75Retinol metabolism_Homo sapiens_hsa008300.58268185
76Pyruvate metabolism_Homo sapiens_hsa006200.56468175
77PPAR signaling pathway_Homo sapiens_hsa033200.56141229
78Peroxisome_Homo sapiens_hsa041460.55989599
79Vitamin B6 metabolism_Homo sapiens_hsa007500.55300260
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.54431982
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53919826
82Nitrogen metabolism_Homo sapiens_hsa009100.52389963
83Ether lipid metabolism_Homo sapiens_hsa005650.51893903
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50490097
85Cardiac muscle contraction_Homo sapiens_hsa042600.48997280
86* Leukocyte transendothelial migration_Homo sapiens_hsa046700.47611817
87beta-Alanine metabolism_Homo sapiens_hsa004100.44945163
88Adherens junction_Homo sapiens_hsa045200.42347618
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42006143
90Insulin resistance_Homo sapiens_hsa049310.40161679
91* Hepatitis C_Homo sapiens_hsa051600.39889211
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38978205
93ABC transporters_Homo sapiens_hsa020100.36829227
94Fatty acid biosynthesis_Homo sapiens_hsa000610.36555864
95RNA polymerase_Homo sapiens_hsa030200.34887665
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.34420802
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32723993
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32397274
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30471041
100Salmonella infection_Homo sapiens_hsa051320.27383642
101Purine metabolism_Homo sapiens_hsa002300.24842975
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.24137363
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.21928985
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20314373
105p53 signaling pathway_Homo sapiens_hsa041150.15992160
106Legionellosis_Homo sapiens_hsa051340.14221651
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.14132201
108Lysosome_Homo sapiens_hsa041420.13973488
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.13830707
110Hippo signaling pathway_Homo sapiens_hsa043900.11855016
111Glucagon signaling pathway_Homo sapiens_hsa049220.11465867
112Biosynthesis of amino acids_Homo sapiens_hsa012300.10957703
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10687199
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.10145928
115AMPK signaling pathway_Homo sapiens_hsa041520.09794420
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.09599390
117Insulin secretion_Homo sapiens_hsa049110.07989428
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.07976172
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.07687312
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.05476578
121Propanoate metabolism_Homo sapiens_hsa006400.04955938
122Insulin signaling pathway_Homo sapiens_hsa049100.03586343
123Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0213266
124Amoebiasis_Homo sapiens_hsa05146-0.0148883
125Endometrial cancer_Homo sapiens_hsa05213-0.0078367

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