CLDN8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.29299003
2cilium or flagellum-dependent cell motility (GO:0001539)7.78771621
3branching involved in prostate gland morphogenesis (GO:0060442)6.81161068
4oligosaccharide biosynthetic process (GO:0009312)6.46210724
5cilium movement (GO:0003341)6.36095048
6COPI coating of Golgi vesicle (GO:0048205)6.04938600
7Golgi transport vesicle coating (GO:0048200)6.04938600
8motile cilium assembly (GO:0044458)5.89400197
9valine metabolic process (GO:0006573)5.88196854
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.69943997
11sulfate transmembrane transport (GO:1902358)5.68000298
12L-fucose catabolic process (GO:0042355)5.35484240
13fucose catabolic process (GO:0019317)5.35484240
14L-fucose metabolic process (GO:0042354)5.35484240
15prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.34754830
16maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.30659508
17intestinal epithelial cell development (GO:0060576)5.16522775
18epithelial cilium movement (GO:0003351)5.10043775
19sperm capacitation (GO:0048240)5.06893543
20regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.87405929
21primary alcohol catabolic process (GO:0034310)4.74554753
22protein retention in ER lumen (GO:0006621)4.67670417
23UDP-N-acetylglucosamine metabolic process (GO:0006047)4.60052861
24sulfate transport (GO:0008272)4.56689046
25prostate gland epithelium morphogenesis (GO:0060740)4.54392388
26fucose metabolic process (GO:0006004)4.53192757
27pyrimidine-containing compound transmembrane transport (GO:0072531)4.53150551
28renal absorption (GO:0070293)4.52800584
29epithelial cell differentiation involved in prostate gland development (GO:0060742)4.50980133
30artery development (GO:0060840)4.50624852
31sulfur amino acid catabolic process (GO:0000098)4.44533830
32bicarbonate transport (GO:0015701)4.43742697
33regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.43477853
34ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.34890812
35water homeostasis (GO:0030104)4.23930396
36ethanol oxidation (GO:0006069)4.22845955
37axoneme assembly (GO:0035082)4.19538384
38N-glycan processing (GO:0006491)4.18311437
39gap junction assembly (GO:0016264)4.17225822
40activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.13255569
41mannose metabolic process (GO:0006013)4.11324646
42establishment of skin barrier (GO:0061436)4.10629011
43branched-chain amino acid metabolic process (GO:0009081)4.10626698
44transcytosis (GO:0045056)4.10226230
45regulation of water loss via skin (GO:0033561)4.10219128
46activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.02440133
47positive regulation of p38MAPK cascade (GO:1900745)3.98600670
48regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.93339026
49epithelial cell maturation (GO:0002070)3.91579774
50galactose catabolic process (GO:0019388)3.90010732
51beta-amyloid metabolic process (GO:0050435)3.87637651
52positive regulation of nuclease activity (GO:0032075)3.80389375
53* calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.74345738
54polyol transport (GO:0015791)3.71333535
55vitamin transmembrane transport (GO:0035461)3.71141020
56hormone catabolic process (GO:0042447)3.70884742
57cysteine metabolic process (GO:0006534)3.62926057
58peptide catabolic process (GO:0043171)3.57954184
59retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.57247649
60sodium ion homeostasis (GO:0055078)3.56163197
61branched-chain amino acid catabolic process (GO:0009083)3.55540142
62positive regulation of steroid hormone secretion (GO:2000833)3.55334027
63opsonization (GO:0008228)3.53356592
64diterpenoid biosynthetic process (GO:0016102)3.52801628
65cellular modified amino acid catabolic process (GO:0042219)3.51769167
66hypotonic response (GO:0006971)3.51050312
67regulation of transforming growth factor beta1 production (GO:0032908)3.49920300
68hemidesmosome assembly (GO:0031581)3.47884621
69left/right pattern formation (GO:0060972)3.47544209
70regulation of receptor binding (GO:1900120)3.44201528
71drug transmembrane transport (GO:0006855)3.44126382
72flavonoid metabolic process (GO:0009812)3.43407759
73regulation of nuclease activity (GO:0032069)3.40458201
74endoplasmic reticulum unfolded protein response (GO:0030968)3.37292940
75transepithelial transport (GO:0070633)3.32547894
76iron ion import (GO:0097286)3.28958710
77positive regulation of catenin import into nucleus (GO:0035413)3.26871262
78response to testosterone (GO:0033574)3.26490977
79regulation of apoptotic process involved in morphogenesis (GO:1902337)3.26083021
80glutathione biosynthetic process (GO:0006750)3.25278357
81cellular response to unfolded protein (GO:0034620)3.25082469
82response to mercury ion (GO:0046689)3.24929613
83carnitine metabolic process (GO:0009437)3.24798008
84positive regulation of growth hormone secretion (GO:0060124)3.23565023
85excretion (GO:0007588)3.22733753
86exocrine pancreas development (GO:0031017)3.22729682
87mitotic cell cycle arrest (GO:0071850)3.22218395
88renal system process involved in regulation of blood volume (GO:0001977)3.21884684
89desmosome organization (GO:0002934)3.21580120
90intestinal absorption (GO:0050892)3.20775780
91keratinocyte development (GO:0003334)3.19516906
92lung secretory cell differentiation (GO:0061140)3.19311172
93biotin metabolic process (GO:0006768)3.18280327
94carnitine transmembrane transport (GO:1902603)3.17470785
95sulfur compound transport (GO:0072348)3.16626027
96ER-nucleus signaling pathway (GO:0006984)3.16212183
972-oxoglutarate metabolic process (GO:0006103)3.15631376
98potassium ion homeostasis (GO:0055075)3.15331340
99bundle of His cell to Purkinje myocyte communication (GO:0086069)3.13007608
100response to endoplasmic reticulum stress (GO:0034976)3.12936340
101apical protein localization (GO:0045176)3.12854505
102peptidyl-tyrosine autophosphorylation (GO:0038083)3.12496254
103nonribosomal peptide biosynthetic process (GO:0019184)3.11828155
104short-chain fatty acid metabolic process (GO:0046459)3.11303747
105purine nucleotide transport (GO:0015865)3.08733978
106regulation of p38MAPK cascade (GO:1900744)3.08187359
107galactose metabolic process (GO:0006012)3.07429152
108purine ribonucleotide transport (GO:0015868)3.04432755
109COPII vesicle coating (GO:0048208)3.03868152
110amino-acid betaine transport (GO:0015838)3.03848640
111carnitine transport (GO:0015879)3.03848640
112zinc ion transport (GO:0006829)3.01936055
113nucleoside bisphosphate biosynthetic process (GO:0033866)3.01657430
114purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.01657430
115ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.01657430
116cellular response to topologically incorrect protein (GO:0035967)3.00582399
117thyroid hormone generation (GO:0006590)2.97651725
118cellular glucuronidation (GO:0052695)2.96925240
119positive regulation of natural killer cell differentiation (GO:0032825)2.95571566
120primary alcohol metabolic process (GO:0034308)2.94992442
121hexose catabolic process (GO:0019320)2.94588400
122regulation of cilium movement (GO:0003352)2.93953571
123apoptotic cell clearance (GO:0043277)2.91406328
124one-carbon compound transport (GO:0019755)2.89902806
125regulation of protein glycosylation (GO:0060049)2.89043553
126lysine catabolic process (GO:0006554)2.88928021
127lysine metabolic process (GO:0006553)2.88928021
128fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.88916812
129regulation of intracellular pH (GO:0051453)2.88613330
130pharyngeal system development (GO:0060037)2.88270661
131ventricular cardiac muscle cell action potential (GO:0086005)2.88232977
132protein N-linked glycosylation via asparagine (GO:0018279)2.87804622
133urate metabolic process (GO:0046415)2.87150528
134glucuronate metabolic process (GO:0019585)2.87057681
135uronic acid metabolic process (GO:0006063)2.87057681
136peptidyl-asparagine modification (GO:0018196)2.85732744
137regulation of interleukin-5 production (GO:0032674)2.85504839
138mammary gland alveolus development (GO:0060749)2.84308473
139regulation of interleukin-13 production (GO:0032656)2.84242686
140positive regulation of synaptic transmission, GABAergic (GO:0032230)2.84204839
141ethanol metabolic process (GO:0006067)2.81742658
142actin filament depolymerization (GO:0030042)2.80012369
143keratinocyte proliferation (GO:0043616)2.78324215
144positive regulation of fatty acid beta-oxidation (GO:0032000)2.76996604
145multicellular organismal water homeostasis (GO:0050891)2.76929260
146negative regulation of keratinocyte proliferation (GO:0010839)2.76886317
147retinoic acid metabolic process (GO:0042573)2.76560923
148drug transport (GO:0015893)2.76304584
149negative regulation of cell fate commitment (GO:0010454)2.75244546
150O-glycan processing (GO:0016266)2.74295227
151mammary gland epithelial cell differentiation (GO:0060644)2.73925001
152one-carbon metabolic process (GO:0006730)2.73724037
153quaternary ammonium group transport (GO:0015697)2.71235809
154amino-acid betaine metabolic process (GO:0006577)2.70594471
155phosphate ion transport (GO:0006817)2.70522495
156regulation of tight junction assembly (GO:2000810)2.70150724
157glomerular epithelial cell development (GO:0072310)2.69975060
158left/right axis specification (GO:0070986)2.69834335
159protein N-linked glycosylation (GO:0006487)2.69756073
160sequestering of metal ion (GO:0051238)2.68920886
161ectoderm development (GO:0007398)2.68536894
162thyroid hormone metabolic process (GO:0042403)2.68093351
163monosaccharide catabolic process (GO:0046365)2.67781052
164angiotensin maturation (GO:0002003)2.65854438
165oxaloacetate metabolic process (GO:0006107)2.63864603
166vesicle coating (GO:0006901)2.63807308
167sphingomyelin metabolic process (GO:0006684)2.63729484
168fucosylation (GO:0036065)2.63691979
169proline metabolic process (GO:0006560)2.63602331
170glandular epithelial cell differentiation (GO:0002067)2.62629407
171monovalent inorganic cation homeostasis (GO:0055067)2.59870735
172antibacterial humoral response (GO:0019731)2.58371225
173tricarboxylic acid metabolic process (GO:0072350)2.58368309
174positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.57912415
175regulation of pH (GO:0006885)2.56417208
176regulation of cellular pH (GO:0030641)2.54663532
177regulation of protein localization to cell surface (GO:2000008)2.53971779
178asymmetric protein localization (GO:0008105)2.53073668
179neurotransmitter biosynthetic process (GO:0042136)2.50613064
180auditory receptor cell differentiation (GO:0042491)2.47967187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.44046831
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.32470977
3ESR1_21235772_ChIP-Seq_MCF-7_Human4.08782364
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.86990207
5* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.32929179
6SOX2_27498859_Chip-Seq_STOMACH_Mouse3.11872146
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.84388987
8ZNF217_24962896_ChIP-Seq_MCF-7_Human2.73082943
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.56335149
10SOX2_20726797_ChIP-Seq_SW620_Human2.55313143
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.44037811
12ZNF263_19887448_ChIP-Seq_K562_Human2.38474618
13CLOCK_20551151_ChIP-Seq_293T_Human2.36891995
14FOXO3_23340844_ChIP-Seq_DLD1_Human2.36497352
15FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.29170168
16GATA4_25053715_ChIP-Seq_YYC3_Human2.28951848
17* AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.19087826
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16049629
19FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.11279181
20SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.03673069
21GATA6_25053715_ChIP-Seq_YYC3_Human2.00459970
22LXR_22158963_ChIP-Seq_LIVER_Mouse1.98049483
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97308741
24AHR_22903824_ChIP-Seq_MCF-7_Human1.95831550
25* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.94228137
26ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.93552415
27RXR_22158963_ChIP-Seq_LIVER_Mouse1.92202427
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.92097700
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.88752493
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.88686130
31PPARA_22158963_ChIP-Seq_LIVER_Mouse1.85004066
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74624126
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72813496
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70816429
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.68633602
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66568247
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65594613
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62840565
39SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.61100318
40SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.61100318
41AR_21909140_ChIP-Seq_LNCAP_Human1.59796729
42GATA3_24758297_ChIP-Seq_MCF-7_Human1.59590564
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.58900255
44ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.55322571
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.54909242
46FOXM1_26456572_ChIP-Seq_MCF-7_Human1.54410812
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.54137719
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52319514
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51249801
50DROSHA_22980978_ChIP-Seq_HELA_Human1.50915748
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50259759
52GATA1_22025678_ChIP-Seq_K562_Human1.49765780
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48385473
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48385473
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48385473
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.45466809
57* FOXA1_25552417_ChIP-Seq_VCAP_Human1.45133754
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41158004
59CHD1_26751641_Chip-Seq_LNCaP_Human1.40850814
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.39167560
61SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37410887
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35520857
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35520857
64RACK7_27058665_Chip-Seq_MCF-7_Human1.33451813
65TCF4_18268006_ChIP-ChIP_LS174T_Human1.32249832
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30959927
67RXR_22108803_ChIP-Seq_LS180_Human1.27870384
68KLF5_25053715_ChIP-Seq_YYC3_Human1.20772722
69TP63_23658742_ChIP-Seq_EP156T_Human1.18590869
70CJUN_26792858_Chip-Seq_BT549_Human1.16772818
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16120128
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14530748
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14250188
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14199922
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13650987
76* PIAS1_25552417_ChIP-Seq_VCAP_Human1.13090651
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10648015
78* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10272520
79P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09738992
80ATF3_27146783_Chip-Seq_COLON_Human1.09703297
81AR_21572438_ChIP-Seq_LNCaP_Human1.08338171
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07008444
83STAT1_20625510_ChIP-Seq_HELA_Human1.06294845
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05788268
85TBX20_22080862_ChIP-Seq_HEART_Mouse1.05475231
86TBX20_22328084_ChIP-Seq_HEART_Mouse1.05475231
87CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05029620
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04824642
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04805352
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04091925
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03519031
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02584121
93TP63_22573176_ChIP-Seq_HFKS_Human1.02156530
94* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.02023691
95CREB1_26743006_Chip-Seq_LNCaP_Human1.01936371
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97798575
97CEBPB_22108803_ChIP-Seq_LS180_Human0.97283398
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96133510
99* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95740288
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.92168120
101ISL1_27105846_Chip-Seq_CPCs_Mouse0.91729826
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90809177
103ELF5_23300383_ChIP-Seq_T47D_Human0.89565175
104CDX2_22108803_ChIP-Seq_LS180_Human0.89458393
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87268501
106PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87037709
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85732830
108EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84195954
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.84118344
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83579603
111* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82722911
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80600616
113SMC4_20622854_ChIP-Seq_HELA_Human0.80521238
114IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.78124647
115TCF4_22108803_ChIP-Seq_LS180_Human0.76381712
116GATA1_19941826_ChIP-Seq_K562_Human0.74309038
117PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.73308222
118GATA2_19941826_ChIP-Seq_K562_Human0.72205656
119KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65756879
120NFIB_24661679_ChIP-Seq_LUNG_Mouse0.65578883
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.65494471
122HNF4A_19822575_ChIP-Seq_HepG2_Human0.65483228
123CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.64114274

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.62216113
2MP0004043_abnormal_pH_regulation4.59325349
3MP0003300_gastrointestinal_ulcer4.19960032
4MP0009379_abnormal_foot_pigmentation3.20881396
5MP0004264_abnormal_extraembryonic_tissu3.17135031
6MP0005310_abnormal_salivary_gland3.06716944
7MP0000537_abnormal_urethra_morphology3.01762902
8MP0010386_abnormal_urinary_bladder3.00930712
9MP0001756_abnormal_urination2.84603579
10MP0001765_abnormal_ion_homeostasis2.77251747
11MP0002166_altered_tumor_susceptibility2.77039909
12MP0002277_abnormal_respiratory_mucosa2.51290200
13MP0001873_stomach_inflammation2.42088937
14MP0001881_abnormal_mammary_gland2.41825829
15MP0002009_preneoplasia2.29485141
16MP0009643_abnormal_urine_homeostasis2.22168059
17MP0001666_abnormal_nutrient_absorption2.18163685
18MP0000613_abnormal_salivary_gland2.14917501
19MP0002006_tumorigenesis2.04880821
20MP0005647_abnormal_sex_gland2.04369764
21MP0005636_abnormal_mineral_homeostasis2.02344986
22MP0002796_impaired_skin_barrier2.00533726
23MP0002098_abnormal_vibrissa_morphology1.97477600
24MP0000538_abnormal_urinary_bladder1.94862134
25MP0002139_abnormal_hepatobiliary_system1.92509833
26MP0005220_abnormal_exocrine_pancreas1.92403649
27MP0003705_abnormal_hypodermis_morpholog1.88879469
28MP0010678_abnormal_skin_adnexa1.84484937
29MP0005332_abnormal_amino_acid1.79232118
30MP0004019_abnormal_vitamin_homeostasis1.73996485
31MP0008961_abnormal_basal_metabolism1.72402218
32MP0002136_abnormal_kidney_physiology1.67526602
33MP0009780_abnormal_chondrocyte_physiolo1.66654191
34MP0001346_abnormal_lacrimal_gland1.58962221
35MP0002653_abnormal_ependyma_morphology1.55919044
36MP0003195_calcinosis1.54147247
37MP0003868_abnormal_feces_composition1.50280949
38MP0006054_spinal_hemorrhage1.49507525
39MP0000516_abnormal_urinary_system1.44415921
40MP0005367_renal/urinary_system_phenotyp1.44415921
41MP0000678_abnormal_parathyroid_gland1.43922884
42MP0003941_abnormal_skin_development1.39212757
43MP0005365_abnormal_bile_salt1.36835296
44MP0005408_hypopigmentation1.36094799
45MP0010352_gastrointestinal_tract_polyps1.33651433
46MP0004885_abnormal_endolymph1.32557105
47MP0005058_abnormal_lysosome_morphology1.31428151
48MP0009384_cardiac_valve_regurgitation1.31296107
49MP0004782_abnormal_surfactant_physiolog1.28082724
50MP0000534_abnormal_ureter_morphology1.27217046
51MP0003183_abnormal_peptide_metabolism1.26765881
52MP0005670_abnormal_white_adipose1.26733965
53MP0008875_abnormal_xenobiotic_pharmacok1.25746249
54MP0009764_decreased_sensitivity_to1.24765885
55MP0001664_abnormal_digestion1.24330477
56MP0003315_abnormal_perineum_morphology1.23150122
57MP0000377_abnormal_hair_follicle1.20712372
58MP0000627_abnormal_mammary_gland1.18350357
59MP0005083_abnormal_biliary_tract1.16493581
60MP0005360_urolithiasis1.15805440
61MP0000462_abnormal_digestive_system1.13566679
62MP0005645_abnormal_hypothalamus_physiol1.08982018
63MP0005381_digestive/alimentary_phenotyp1.08373268
64MP0002896_abnormal_bone_mineralization1.05811095
65MP0004272_abnormal_basement_membrane1.05320559
66MP0002060_abnormal_skin_morphology1.04203455
67MP0001984_abnormal_olfaction1.03321056
68MP0001663_abnormal_digestive_system1.02799964
69MP0005275_abnormal_skin_tensile1.02305128
70MP0000681_abnormal_thyroid_gland1.01467020
71MP0005501_abnormal_skin_physiology1.01005457
72MP0000566_synostosis0.99997447
73MP0003566_abnormal_cell_adhesion0.98248992
74MP0001216_abnormal_epidermal_layer0.97314059
75MP0000762_abnormal_tongue_morphology0.96704980
76MP0003866_abnormal_defecation0.96400119
77MP0002295_abnormal_pulmonary_circulatio0.90282770
78MP0002135_abnormal_kidney_morphology0.90011178
79MP0002876_abnormal_thyroid_physiology0.89190419
80MP0005395_other_phenotype0.89054089
81MP0005085_abnormal_gallbladder_physiolo0.89022145
82MP0003186_abnormal_redox_activity0.88734575
83MP0001958_emphysema0.88019445
84MP0000579_abnormal_nail_morphology0.87940859
85MP0010155_abnormal_intestine_physiology0.86539110
86MP0002138_abnormal_hepatobiliary_system0.86125027
87MP0003045_fibrosis0.85631376
88MP0000383_abnormal_hair_follicle0.85597488
89MP0005409_darkened_coat_color0.84757207
90MP0002254_reproductive_system_inflammat0.83629639
91MP0001299_abnormal_eye_distance/0.83604958
92MP0001485_abnormal_pinna_reflex0.82333675
93MP0001188_hyperpigmentation0.81258940
94MP0008004_abnormal_stomach_pH0.81155307
95MP0009765_abnormal_xenobiotic_induced0.80833552
96MP0002132_abnormal_respiratory_system0.80511431
97MP0003453_abnormal_keratinocyte_physiol0.79574112
98MP0005319_abnormal_enzyme/_coenzyme0.79010274
99MP0005666_abnormal_adipose_tissue0.78530366
100MP0005187_abnormal_penis_morphology0.78270420
101MP0004147_increased_porphyrin_level0.78122711
102MP0001849_ear_inflammation0.77932972
103MP0010771_integument_phenotype0.76093144
104MP0000467_abnormal_esophagus_morphology0.75186998
105MP0003252_abnormal_bile_duct0.75186884
106MP0000230_abnormal_systemic_arterial0.74290557
107MP0002909_abnormal_adrenal_gland0.73874706
108MP0002168_other_aberrant_phenotype0.73195270
109MP0005248_abnormal_Harderian_gland0.72609182
110MP0000465_gastrointestinal_hemorrhage0.72268679
111MP0009053_abnormal_anal_canal0.72166739
112MP0005076_abnormal_cell_differentiation0.71194706
113MP0003936_abnormal_reproductive_system0.69281821
114MP0003656_abnormal_erythrocyte_physiolo0.68015269
115MP0000490_abnormal_crypts_of0.67766053
116MP0004947_skin_inflammation0.67045449
117MP0003638_abnormal_response/metabolism_0.66708378
118MP0000470_abnormal_stomach_morphology0.66706391
119MP0000427_abnormal_hair_cycle0.66169881
120MP0004858_abnormal_nervous_system0.65191947
121MP0005023_abnormal_wound_healing0.64689018
122MP0004185_abnormal_adipocyte_glucose0.64480440
123MP0000477_abnormal_intestine_morphology0.62916109
124MP0002118_abnormal_lipid_homeostasis0.57265973
125MP0003718_maternal_effect0.56086634
126MP0008789_abnormal_olfactory_epithelium0.53834633
127MP0005166_decreased_susceptibility_to0.52377465
128MP0001270_distended_abdomen0.51568619

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.04376055
2Hyperactive renin-angiotensin system (HP:0000841)6.12610023
3Chronic bronchitis (HP:0004469)5.87415460
4Abnormal respiratory motile cilium physiology (HP:0012261)5.86160450
5Abnormal respiratory epithelium morphology (HP:0012253)5.79186109
6Abnormal respiratory motile cilium morphology (HP:0005938)5.79186109
7Hypokalemic alkalosis (HP:0001949)5.67009081
8Abnormality of chloride homeostasis (HP:0011422)5.62900658
9Dynein arm defect of respiratory motile cilia (HP:0012255)5.58014258
10Absent/shortened dynein arms (HP:0200106)5.58014258
11Rhinitis (HP:0012384)5.55758889
12Abnormal ciliary motility (HP:0012262)5.54822586
13Metabolic alkalosis (HP:0200114)5.53515149
14Abnormality of cochlea (HP:0000375)5.53323224
15Hypomagnesemia (HP:0002917)5.48951190
16Increased circulating renin level (HP:0000848)5.01332577
17Abnormality of magnesium homeostasis (HP:0004921)4.60746025
18Decreased circulating renin level (HP:0003351)4.58460136
19Abnormality of renal excretion (HP:0011036)4.56534089
20Flat acetabular roof (HP:0003180)4.55651532
21Bronchiectasis (HP:0002110)4.47771704
22Abnormal urine output (HP:0012590)4.45754287
23Renal salt wasting (HP:0000127)4.29961888
24Polyuria (HP:0000103)4.15047625
25Hyperaldosteronism (HP:0000859)3.99102181
26Morphological abnormality of the inner ear (HP:0011390)3.95291936
27Gout (HP:0001997)3.76560301
28Hyperglycinuria (HP:0003108)3.60051701
29Aortic aneurysm (HP:0004942)3.57974100
30Potter facies (HP:0002009)3.56522937
31Facial shape deformation (HP:0011334)3.56522937
32Polydipsia (HP:0001959)3.48926553
33Abnormal drinking behavior (HP:0030082)3.48926553
34Nasal polyposis (HP:0100582)3.43410738
35Hypokalemia (HP:0002900)3.42083595
36Right ventricular cardiomyopathy (HP:0011663)3.41596018
37Vacuolated lymphocytes (HP:0001922)3.39396107
38Abnormality of renin-angiotensin system (HP:0000847)3.33959229
39Tetany (HP:0001281)3.32053295
40Bronchitis (HP:0012387)3.20378092
41Abnormality of the nasal mucosa (HP:0000433)3.16531413
42Hyperkalemia (HP:0002153)3.14984922
43Pili torti (HP:0003777)2.98523501
44Alkalosis (HP:0001948)2.94182389
45Abnormality of glycine metabolism (HP:0010895)2.70358534
46Abnormality of serine family amino acid metabolism (HP:0010894)2.70358534
47Onycholysis (HP:0001806)2.69341693
48Widely patent fontanelles and sutures (HP:0004492)2.68648414
49Abnormality of purine metabolism (HP:0004352)2.68077296
50Aortic dissection (HP:0002647)2.63052905
51Abnormality of potassium homeostasis (HP:0011042)2.61887813
52Rectal prolapse (HP:0002035)2.60319347
53Dehydration (HP:0001944)2.59047684
54Hypoplasia of the uterus (HP:0000013)2.58167177
55Infertility (HP:0000789)2.56279086
56Abnormality of permanent molar morphology (HP:0011071)2.52145769
57Abnormality of the dental root (HP:0006486)2.52145769
58Taurodontia (HP:0000679)2.52145769
59Flattened epiphyses (HP:0003071)2.48953117
60Male infertility (HP:0003251)2.45845967
61Shawl scrotum (HP:0000049)2.44368875
62Abnormality of the 2nd finger (HP:0004100)2.43619941
63Abnormality of the distal phalanx of the thumb (HP:0009617)2.40025831
64Tubulointerstitial fibrosis (HP:0005576)2.39663974
65Recurrent otitis media (HP:0000403)2.39604411
66Chronic sinusitis (HP:0011109)2.32898751
67Spinal cord compression (HP:0002176)2.32423705
68Abnormality of fatty-acid metabolism (HP:0004359)2.31653997
69Neonatal short-limb short stature (HP:0008921)2.31336655
70Abnormality of molar morphology (HP:0011070)2.31077081
71Abnormality of molar (HP:0011077)2.31077081
72Lip pit (HP:0100267)2.30556542
73Proximal tubulopathy (HP:0000114)2.28222349
74Recurrent sinusitis (HP:0011108)2.28031761
75Abnormal foot bone ossification (HP:0010675)2.27172449
76Subcapsular cataract (HP:0000523)2.25561113
77Hyperuricemia (HP:0002149)2.23380773
78Increased purine levels (HP:0004368)2.23380773
79Abnormality of the dental pulp (HP:0006479)2.23129133
80Abnormality of carpal bone ossification (HP:0006257)2.21489107
81Ketoacidosis (HP:0001993)2.18904117
82Aplasia of the phalanges of the hand (HP:0009802)2.14440306
83Aplasia involving bones of the extremities (HP:0009825)2.14440306
84Aplasia involving bones of the upper limbs (HP:0009823)2.14440306
85Abnormality of the axillary hair (HP:0100134)2.13351067
86Abnormality of secondary sexual hair (HP:0009888)2.13351067
87Glomerulosclerosis (HP:0000096)2.13082462
88Intrahepatic cholestasis (HP:0001406)2.11765573
89Hyperglycinemia (HP:0002154)2.09877863
90Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.08946176
91Abdominal distention (HP:0003270)2.08734964
92Mucopolysacchariduria (HP:0008155)2.06442874
93Urinary glycosaminoglycan excretion (HP:0003541)2.06442874
94Woolly hair (HP:0002224)2.05724542
95Malnutrition (HP:0004395)2.04459742
96Dysostosis multiplex (HP:0000943)2.01140799
97Hypoplastic labia majora (HP:0000059)1.99825386
98Hypercalciuria (HP:0002150)1.98046104
99Abnormality of monocarboxylic acid metabolism (HP:0010996)1.97864948
100Milia (HP:0001056)1.97535162
101Visceral angiomatosis (HP:0100761)1.94403824
102Abnormal tarsal ossification (HP:0008369)1.92662225
103Abnormality of polysaccharide metabolism (HP:0011012)1.91552384
104Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91552384
105Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91552384
106Abnormality of the middle phalanges of the toes (HP:0010183)1.91346519
107Hydroxyprolinuria (HP:0003080)1.90584887
108Abnormality of proline metabolism (HP:0010907)1.90584887
109Hypotension (HP:0002615)1.90197714
110Abnormal hair laboratory examination (HP:0003328)1.89937700
111Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.88582546
112Abnormal vertebral ossification (HP:0100569)1.88067578
113Exocrine pancreatic insufficiency (HP:0001738)1.87200939
114Hypoplastic nipples (HP:0002557)1.86888362
115Short hallux (HP:0010109)1.85496476
116Hyponatremia (HP:0002902)1.84142052
117Abnormality of the intrinsic pathway (HP:0010989)1.83852975
118Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.83688088
119Vertebral hypoplasia (HP:0008417)1.83688088
120Tetraparesis (HP:0002273)1.83603054
121Atelectasis (HP:0100750)1.83011391
122Protuberant abdomen (HP:0001538)1.82657624
123Renal tubular acidosis (HP:0001947)1.81967694
124Abnormality of the distal phalanges of the toes (HP:0010182)1.80760410
125Ketosis (HP:0001946)1.80051579
126Abnormality of sodium homeostasis (HP:0010931)1.79792001
127Vascular calcification (HP:0004934)1.78429846
128Biliary tract neoplasm (HP:0100574)1.77883571
129Adrenal overactivity (HP:0002717)1.77656871
130Hemangiomatosis (HP:0007461)1.76246104
131Aplasia/hypoplasia of the femur (HP:0005613)1.76194000
132Abnormality of the labia majora (HP:0012881)1.75941696
133Abnormal cartilage morphology (HP:0002763)1.73927304
134Ureteral obstruction (HP:0006000)1.72410778
135Tubular atrophy (HP:0000092)1.72363676
136Wide cranial sutures (HP:0010537)1.71649768
137Long toe (HP:0010511)1.71319751
138Ureteral stenosis (HP:0000071)1.71189302
139Aplasia/Hypoplasia of the hallux (HP:0008362)1.70589206
140Epiphyseal dysplasia (HP:0002656)1.70328771
141Abnormal hand bone ossification (HP:0010660)1.70305275
142Generalized aminoaciduria (HP:0002909)1.69550892
143Flat capital femoral epiphysis (HP:0003370)1.68928609
144Hyperphosphatemia (HP:0002905)1.67261293
145Abnormality of glutamine family amino acid metabolism (HP:0010902)1.66219936
146Thin bony cortex (HP:0002753)1.65992400
147Hypoplasia of the ulna (HP:0003022)1.65327514
148Abnormality of the 1st metacarpal (HP:0010009)1.65294728
149Abnormality of the proximal phalanges of the hand (HP:0009834)1.64263695
150Short middle phalanx of finger (HP:0005819)1.60438611
151Amelogenesis imperfecta (HP:0000705)1.59286670
152Curly hair (HP:0002212)1.58976548
153Cone-rod dystrophy (HP:0000548)1.57950453
154Abnormal ossification of hand bones (HP:0005921)1.55936434
155Conjugated hyperbilirubinemia (HP:0002908)1.52848568
156Hypoplasia of dental enamel (HP:0006297)1.51656065
157Chondrocalcinosis (HP:0000934)1.48742797
158Cardiovascular calcification (HP:0011915)1.48322891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.73225397
2MST44.71829384
3FRK4.46586413
4AKT34.39247189
5STK244.35082105
6MAPK154.07894934
7OXSR13.86782838
8LATS13.80058908
9ERN12.99979326
10WNK42.88726073
11TAOK32.83666092
12BCKDK2.79878598
13EEF2K2.57912351
14PDK22.27660294
15SIK12.26633953
16MYLK2.21483567
17ACVR1B2.06568909
18MST1R2.03849947
19LMTK21.98684542
20MAP3K21.96283307
21MAPKAPK31.85264053
22NUAK11.64318869
23WNK31.59553049
24LRRK21.56121941
25SMG11.54548321
26TTN1.50776372
27SCYL21.46446091
28STK38L1.44656455
29RPS6KB21.37474809
30PTK61.37099218
31FER1.35046316
32BRSK21.34922443
33TRIB31.29330928
34EPHA21.24501817
35EPHB21.17343957
36PIK3CA1.12397877
37STK101.12119518
38ICK1.10775669
39DDR21.03486704
40TRPM71.02277750
41PKN21.01901255
42PIK3CG0.98450593
43MARK20.97886551
44MET0.92154785
45MAP3K30.89104823
46MAP2K20.88175678
47BCR0.85510142
48PDK30.84584220
49PDK40.84584220
50STK30.84524990
51SGK20.81970389
52ARAF0.81485248
53SGK2230.79717307
54SGK4940.79717307
55PRKD20.79233631
56SGK30.78436576
57PIM20.76777060
58MAP3K120.74881783
59RIPK40.71249925
60TNK20.68163546
61NEK60.67662773
62PRKG20.67625733
63TESK10.67323559
64DMPK0.66528286
65NLK0.65995038
66ILK0.64941627
67STK380.64798528
68PAK20.64285118
69INSRR0.64207525
70PRKCI0.62477638
71CAMKK20.59964743
72EPHA30.56344071
73DAPK20.56131947
74WNK10.54503860
75ERBB30.53000358
76RIPK10.51154446
77CAMK1D0.48796445
78PTK20.47894330
79IRAK10.46167258
80MAPK70.45960774
81PDGFRB0.45907528
82JAK20.45160521
83RPS6KA20.44936973
84PDGFRA0.44792847
85MAP3K70.43047969
86SGK10.41689739
87ROCK10.40968491
88LATS20.40717565
89FGFR20.39002469
90PDPK10.37998869
91YES10.37165204
92PAK40.36927992
93RPS6KB10.36462417
94ROCK20.34864343
95JAK30.34323022
96TTK0.33389992
97TESK20.33374688
98KSR20.32968527
99MAP2K60.32441711
100CSNK1A10.32419510
101PRKAA10.32148697
102IGF1R0.31784392
103PRKCE0.31690588
104CHUK0.30168623
105MAPK120.29684010
106CAMK1G0.29553908
107EPHB10.28622524
108GRK10.28160953
109CAMKK10.27832035
110RET0.27594588
111MAP2K10.26782844
112ERBB20.24427176
113PRKCD0.24261712
114MTOR0.24023783
115MAP3K80.24002276
116PDK10.23765166
117TYK20.22784372
118CSK0.22043328
119GSK3A0.20147268
120PRKAA20.18669224
121PRKD30.18487972
122PRKCA0.17101690
123MELK0.16147104
124NTRK10.15225479
125TAOK10.15201703
126TGFBR10.15069693
127PRKD10.14972464
128MAP3K130.14934558
129BMX0.14741098
130JAK10.14686778
131PAK30.14508295
132TGFBR20.14469461
133MINK10.13947627
134CAMK2G0.13876700
135NME10.08996014
136MATK0.08834363
137RPS6KC10.08429277
138RPS6KL10.08429277
139EGFR0.08293038
140FGFR30.08250598

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.41791162
2Sulfur metabolism_Homo sapiens_hsa009204.35567199
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.93967626
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.86372389
5Propanoate metabolism_Homo sapiens_hsa006402.51024251
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.46974630
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40312092
8Protein export_Homo sapiens_hsa030602.31364306
9Phenylalanine metabolism_Homo sapiens_hsa003602.22654795
10Protein digestion and absorption_Homo sapiens_hsa049742.15676877
11Other glycan degradation_Homo sapiens_hsa005112.10892045
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.00887635
13Fatty acid biosynthesis_Homo sapiens_hsa000611.98862359
14N-Glycan biosynthesis_Homo sapiens_hsa005101.97319028
15Fatty acid degradation_Homo sapiens_hsa000711.87731471
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78240121
17Vibrio cholerae infection_Homo sapiens_hsa051101.71667742
18Tyrosine metabolism_Homo sapiens_hsa003501.70252673
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65649422
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63091906
21Renin-angiotensin system_Homo sapiens_hsa046141.61120392
22Caffeine metabolism_Homo sapiens_hsa002321.60781459
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56015115
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.54243131
25Pancreatic secretion_Homo sapiens_hsa049721.52741978
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.46979552
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44049618
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.43731652
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.42689543
30Retinol metabolism_Homo sapiens_hsa008301.37726183
31Collecting duct acid secretion_Homo sapiens_hsa049661.33178137
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30448787
33Pyruvate metabolism_Homo sapiens_hsa006201.25080163
34Bladder cancer_Homo sapiens_hsa052191.21521149
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21098515
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18785976
37Thyroid hormone synthesis_Homo sapiens_hsa049181.14609356
38ECM-receptor interaction_Homo sapiens_hsa045121.14370600
39Mineral absorption_Homo sapiens_hsa049781.09611307
40* Tight junction_Homo sapiens_hsa045301.08976384
41Gastric acid secretion_Homo sapiens_hsa049711.08011130
42Adherens junction_Homo sapiens_hsa045201.07594264
43Prostate cancer_Homo sapiens_hsa052151.07388247
44Fatty acid metabolism_Homo sapiens_hsa012121.07058102
45beta-Alanine metabolism_Homo sapiens_hsa004101.04549890
46Sulfur relay system_Homo sapiens_hsa041221.03385744
47Endometrial cancer_Homo sapiens_hsa052131.03055018
48Selenocompound metabolism_Homo sapiens_hsa004500.97748104
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.92695778
50Hippo signaling pathway_Homo sapiens_hsa043900.90902884
51Lysosome_Homo sapiens_hsa041420.90221023
52Glycerolipid metabolism_Homo sapiens_hsa005610.90078632
53Linoleic acid metabolism_Homo sapiens_hsa005910.89984017
54Focal adhesion_Homo sapiens_hsa045100.89539366
55Peroxisome_Homo sapiens_hsa041460.87901878
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81840612
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81412531
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81025746
59Glutathione metabolism_Homo sapiens_hsa004800.80835335
60Small cell lung cancer_Homo sapiens_hsa052220.80708655
61Butanoate metabolism_Homo sapiens_hsa006500.80264990
62Chemical carcinogenesis_Homo sapiens_hsa052040.78752926
63Arachidonic acid metabolism_Homo sapiens_hsa005900.77112432
64Fructose and mannose metabolism_Homo sapiens_hsa000510.74100877
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72757882
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71467994
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71256634
68Amoebiasis_Homo sapiens_hsa051460.70773052
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.70328086
70Insulin resistance_Homo sapiens_hsa049310.68893382
71Arginine biosynthesis_Homo sapiens_hsa002200.68529393
72TGF-beta signaling pathway_Homo sapiens_hsa043500.67684679
73Tryptophan metabolism_Homo sapiens_hsa003800.67425599
74Circadian rhythm_Homo sapiens_hsa047100.66975776
75Arginine and proline metabolism_Homo sapiens_hsa003300.66106303
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64626294
77Bile secretion_Homo sapiens_hsa049760.63498951
78Fat digestion and absorption_Homo sapiens_hsa049750.63226517
79ABC transporters_Homo sapiens_hsa020100.63119131
80Galactose metabolism_Homo sapiens_hsa000520.60649233
81Prolactin signaling pathway_Homo sapiens_hsa049170.59971786
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59954947
83PPAR signaling pathway_Homo sapiens_hsa033200.58003794
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54654640
85Renin secretion_Homo sapiens_hsa049240.53923873
86Histidine metabolism_Homo sapiens_hsa003400.51892617
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50585049
88Pancreatic cancer_Homo sapiens_hsa052120.50283923
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50045418
90Inositol phosphate metabolism_Homo sapiens_hsa005620.49556704
91Proteoglycans in cancer_Homo sapiens_hsa052050.48878795
92Carbon metabolism_Homo sapiens_hsa012000.47525745
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47452108
94Starch and sucrose metabolism_Homo sapiens_hsa005000.47328777
95Thyroid cancer_Homo sapiens_hsa052160.46909883
96* Leukocyte transendothelial migration_Homo sapiens_hsa046700.46500485
97Sphingolipid metabolism_Homo sapiens_hsa006000.45472043
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44021078
99Folate biosynthesis_Homo sapiens_hsa007900.43954487
100AMPK signaling pathway_Homo sapiens_hsa041520.43367862
101Steroid biosynthesis_Homo sapiens_hsa001000.43196351
102Lysine degradation_Homo sapiens_hsa003100.41995592
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41919209
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41688163
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41488825
106Melanoma_Homo sapiens_hsa052180.40752603
107Ether lipid metabolism_Homo sapiens_hsa005650.39691568
108* Hepatitis C_Homo sapiens_hsa051600.39276407
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.37988204
110Salivary secretion_Homo sapiens_hsa049700.37622160
111Vitamin digestion and absorption_Homo sapiens_hsa049770.36488812
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.34227209
113Choline metabolism in cancer_Homo sapiens_hsa052310.33740745
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33583382
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32953084
116mTOR signaling pathway_Homo sapiens_hsa041500.32635397
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.32049466
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31019869
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.28170016
120Notch signaling pathway_Homo sapiens_hsa043300.27229520
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25607428
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24301933
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21289464
124Metabolic pathways_Homo sapiens_hsa011000.21139713
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21055369
126Ovarian steroidogenesis_Homo sapiens_hsa049130.18986433
127Endocytosis_Homo sapiens_hsa041440.14020178
128GnRH signaling pathway_Homo sapiens_hsa049120.12196603
129Huntingtons disease_Homo sapiens_hsa050160.10103447
130Dorso-ventral axis formation_Homo sapiens_hsa043200.08500376
131Fatty acid elongation_Homo sapiens_hsa000620.07921623

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