CLDND1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.75960552
2ensheathment of neurons (GO:0007272)6.21762237
3axon ensheathment (GO:0008366)6.21762237
4myelination (GO:0042552)6.15815497
5long-chain fatty acid biosynthetic process (GO:0042759)6.03116314
6synaptic vesicle maturation (GO:0016188)5.36762714
7glutamate secretion (GO:0014047)5.06916657
8negative regulation of neurotransmitter secretion (GO:0046929)4.97397060
9myelin maintenance (GO:0043217)4.96527871
10cholesterol biosynthetic process (GO:0006695)4.95753771
11cellular potassium ion homeostasis (GO:0030007)4.89863259
12negative regulation of neurotransmitter transport (GO:0051589)4.79555704
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.79290854
14regulation of synaptic vesicle exocytosis (GO:2000300)4.62744487
15synaptic vesicle exocytosis (GO:0016079)4.53597502
16sterol biosynthetic process (GO:0016126)4.39743864
17oligodendrocyte differentiation (GO:0048709)4.37520335
18negative regulation of synaptic transmission, GABAergic (GO:0032229)4.36577782
19membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.35412719
20regulation of collateral sprouting (GO:0048670)4.25589232
21neuronal ion channel clustering (GO:0045161)4.21783162
22sodium ion export (GO:0071436)4.16655891
23eye photoreceptor cell differentiation (GO:0001754)4.16400084
24photoreceptor cell differentiation (GO:0046530)4.16400084
25negative regulation of protein localization to cell surface (GO:2000009)4.15215825
26substantia nigra development (GO:0021762)4.14385846
27potassium ion import (GO:0010107)4.11110792
28regulation of synaptic vesicle transport (GO:1902803)4.07078320
29presynaptic membrane organization (GO:0097090)4.03026158
30postsynaptic membrane organization (GO:0001941)4.02750692
31amyloid precursor protein metabolic process (GO:0042982)3.99885016
32isoprenoid biosynthetic process (GO:0008299)3.94833897
33neuronal action potential propagation (GO:0019227)3.91546374
34presynaptic membrane assembly (GO:0097105)3.90832289
35positive regulation of actin filament depolymerization (GO:0030836)3.86627913
36acidic amino acid transport (GO:0015800)3.86330384
37neurotransmitter secretion (GO:0007269)3.85263794
38protein neddylation (GO:0045116)3.81190202
39potassium ion homeostasis (GO:0055075)3.80260448
40positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.78964046
41response to redox state (GO:0051775)3.78867380
42long-term synaptic potentiation (GO:0060291)3.76287724
43ionotropic glutamate receptor signaling pathway (GO:0035235)3.68928760
44regulation of short-term neuronal synaptic plasticity (GO:0048172)3.68483565
45locomotory exploration behavior (GO:0035641)3.67357372
46cytidine metabolic process (GO:0046087)3.66938457
47cytidine catabolic process (GO:0006216)3.66938457
48cytidine deamination (GO:0009972)3.66938457
49regulation of neuronal synaptic plasticity (GO:0048168)3.62389724
50glycerophospholipid catabolic process (GO:0046475)3.60066453
51limb bud formation (GO:0060174)3.57276745
52apical protein localization (GO:0045176)3.54489974
53long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.54425154
54response to methylmercury (GO:0051597)3.53627739
55establishment of mitochondrion localization (GO:0051654)3.52890177
56virion attachment to host cell (GO:0019062)3.52015693
57adhesion of symbiont to host cell (GO:0044650)3.52015693
58glycosphingolipid biosynthetic process (GO:0006688)3.50094604
59long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.50028258
60L-glutamate transport (GO:0015813)3.47998521
61creatine metabolic process (GO:0006600)3.47417120
62astrocyte development (GO:0014002)3.44106907
63response to lipoprotein particle (GO:0055094)3.43449308
64positive regulation of oligodendrocyte differentiation (GO:0048714)3.42983291
65asymmetric protein localization (GO:0008105)3.42905983
66gamma-aminobutyric acid signaling pathway (GO:0007214)3.42321762
67negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.40858907
68positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.40099522
69neurotransmitter transport (GO:0006836)3.33384381
70pyrimidine ribonucleoside catabolic process (GO:0046133)3.31287757
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.31095669
72astrocyte differentiation (GO:0048708)3.28087663
73DNA deamination (GO:0045006)3.26614610
74detection of calcium ion (GO:0005513)3.25786222
75signal peptide processing (GO:0006465)3.24301328
76gamma-aminobutyric acid transport (GO:0015812)3.24217119
77synaptic transmission, glutamatergic (GO:0035249)3.21960224
78amyloid precursor protein catabolic process (GO:0042987)3.20200774
79GPI anchor biosynthetic process (GO:0006506)3.18649792
80nucleotide transmembrane transport (GO:1901679)3.18071886
81neuron-neuron synaptic transmission (GO:0007270)3.17829336
82regulation of long-term neuronal synaptic plasticity (GO:0048169)3.17579658
83response to lead ion (GO:0010288)3.17272411
84cerebral cortex radially oriented cell migration (GO:0021799)3.15163723
85regulation of voltage-gated calcium channel activity (GO:1901385)3.14425943
86regulation of neurotransmitter transport (GO:0051588)3.14349261
87regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.12394132
88myelination in peripheral nervous system (GO:0022011)3.12230741
89peripheral nervous system axon ensheathment (GO:0032292)3.12230741
90glutamate receptor signaling pathway (GO:0007215)3.11057739
91regulation of neurotransmitter levels (GO:0001505)3.11004293
92cerebellar granule cell differentiation (GO:0021707)3.10809346
93regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.10409385
94regulation of neurotransmitter uptake (GO:0051580)3.10391210
95auditory behavior (GO:0031223)3.09546010
96regulation of neurotransmitter secretion (GO:0046928)3.07248042
97magnesium ion transport (GO:0015693)3.05652634
98L-amino acid import (GO:0043092)3.04699612
99regulation of synaptic transmission, GABAergic (GO:0032228)3.03079391
100C4-dicarboxylate transport (GO:0015740)3.02511574
101neuron cell-cell adhesion (GO:0007158)2.99850304
102GPI anchor metabolic process (GO:0006505)2.99076238
103exploration behavior (GO:0035640)2.98892273
104regulation of dopamine metabolic process (GO:0042053)2.98658690
105regulation of catecholamine metabolic process (GO:0042069)2.98658690
106cellular sodium ion homeostasis (GO:0006883)2.98548207
107regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98070725
108regulation of excitatory postsynaptic membrane potential (GO:0060079)2.95893702
109vocalization behavior (GO:0071625)2.95517005
110negative regulation of JUN kinase activity (GO:0043508)2.95339401
111regulation of synaptic transmission, glutamatergic (GO:0051966)2.94166733
112protein palmitoylation (GO:0018345)2.93300471
113interleukin-6-mediated signaling pathway (GO:0070102)2.92436090
114cerebellar Purkinje cell differentiation (GO:0021702)2.91917595
115negative regulation of axonogenesis (GO:0050771)2.90715294
116import into cell (GO:0098657)2.90686421
117peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.88743976
118regulation of cell communication by electrical coupling (GO:0010649)2.87878758
119peptidyl-tyrosine autophosphorylation (GO:0038083)2.87258138
120positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.85219097
121negative regulation of inclusion body assembly (GO:0090084)2.84761089
122regulation of synaptic plasticity (GO:0048167)2.83964476
123neural nucleus development (GO:0048857)2.83565088
124positive regulation of membrane potential (GO:0045838)2.83549512
125fatty-acyl-CoA biosynthetic process (GO:0046949)2.83303060
126regulation of synapse structural plasticity (GO:0051823)2.83074008
127response to auditory stimulus (GO:0010996)2.82886449
128positive regulation of interleukin-17 production (GO:0032740)2.80236674
129neuron remodeling (GO:0016322)2.80062290
130regulation of dendritic spine development (GO:0060998)2.78898336
131negative regulation of execution phase of apoptosis (GO:1900118)2.78033901
132protein localization to synapse (GO:0035418)2.77745959
133fatty-acyl-CoA metabolic process (GO:0035337)2.76973478
134negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75643271
135axon development (GO:0061564)2.75568492
136glycosylceramide metabolic process (GO:0006677)2.75261536
137cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.74078271
138regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73907524
139negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.73169382
140long-term memory (GO:0007616)2.72540100
141mannosylation (GO:0097502)2.72083183
142peripheral nervous system development (GO:0007422)2.71367189
143dopamine biosynthetic process (GO:0042416)2.71222174
144positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.69321605
145adult walking behavior (GO:0007628)2.67752107
146enteric nervous system development (GO:0048484)2.66969820
147regulation of memory T cell differentiation (GO:0043380)2.65918867
148positive regulation of action potential (GO:0045760)2.65238528
149preassembly of GPI anchor in ER membrane (GO:0016254)2.60696439
150positive regulation of cell fate commitment (GO:0010455)2.60632814
151positive regulation of glial cell differentiation (GO:0045687)2.59508701
152chaperone-mediated protein transport (GO:0072321)2.59485109
153positive regulation of gliogenesis (GO:0014015)2.58593679
154response to epinephrine (GO:0071871)2.58540605
155negative regulation of axon extension (GO:0030517)2.56259843
156membrane assembly (GO:0071709)2.55321869
157neurotransmitter uptake (GO:0001504)2.54962547
158negative regulation of exocytosis (GO:0045920)2.54673390
159Rap protein signal transduction (GO:0032486)2.53479096
160regulation of lipoprotein metabolic process (GO:0050746)2.53366395
161peptidyl-cysteine modification (GO:0018198)2.52577139
162very long-chain fatty acid metabolic process (GO:0000038)2.51004544
163membrane tubulation (GO:0097320)2.49718389
164membrane raft organization (GO:0031579)2.48263015
165transmission of nerve impulse (GO:0019226)2.47511326
166glial cell development (GO:0021782)2.46425228
167mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.44366718
168cellular response to epinephrine stimulus (GO:0071872)2.40534031
169amino acid import (GO:0043090)2.40473993
170nucleotide transport (GO:0006862)2.40433206
171adhesion of symbiont to host (GO:0044406)2.40350783
172negative regulation of acute inflammatory response (GO:0002674)2.40100840
173positive regulation of pseudopodium assembly (GO:0031274)2.39314236
174leukocyte migration involved in inflammatory response (GO:0002523)2.36730205
175mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.36088298
176positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.36088298
177axon ensheathment in central nervous system (GO:0032291)10.3474486
178central nervous system myelination (GO:0022010)10.3474486

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.22844744
2SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.78013417
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.66039993
4TAF15_26573619_Chip-Seq_HEK293_Human2.59638990
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51570044
6AR_21572438_ChIP-Seq_LNCaP_Human2.35432016
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34842902
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31303784
9OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.26397461
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22482648
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.19033559
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16535872
13REST_21632747_ChIP-Seq_MESCs_Mouse2.16027988
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.12874018
15VDR_22108803_ChIP-Seq_LS180_Human2.06899322
16ER_23166858_ChIP-Seq_MCF-7_Human2.05724704
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05724620
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.04768096
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99626136
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94443269
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.94041589
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.93542004
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93135136
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.91289348
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91241020
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.89318410
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83067948
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.73847950
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73821841
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72575632
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72575632
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.70096394
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69582621
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68333201
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65080497
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.63163598
37P300_19829295_ChIP-Seq_ESCs_Human1.59633874
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59517651
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59365252
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.59119835
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57019073
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55789214
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54831478
44FUS_26573619_Chip-Seq_HEK293_Human1.54646456
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.54488062
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53786333
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53786333
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53069968
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.52301655
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.51863100
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51391653
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50721489
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.49768620
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49420728
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47753682
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.47305786
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47110452
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45023947
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.43198187
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39083039
61TCF4_23295773_ChIP-Seq_U87_Human1.37831635
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37678916
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.34751355
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33902988
65EZH2_22144423_ChIP-Seq_EOC_Human1.33399019
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33384110
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.31839127
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27937404
69TAL1_26923725_Chip-Seq_HPCs_Mouse1.26793727
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.26470109
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26389724
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.24745440
73SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23952877
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.23542522
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.22268232
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21908821
77OCT4_18555785_Chip-Seq_ESCs_Mouse1.21168354
78PU1_27457419_Chip-Seq_LIVER_Mouse1.19226664
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18746566
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.18283723
81AR_25329375_ChIP-Seq_VCAP_Human1.17672113
82NMYC_18555785_Chip-Seq_ESCs_Mouse1.17536232
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.17498710
84SMAD1_18555785_Chip-Seq_ESCs_Mouse1.17382824
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16758181
86RNF2_27304074_Chip-Seq_NSC_Mouse1.16324162
87DROSHA_22980978_ChIP-Seq_HELA_Human1.15008733
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14977009
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14945183
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14666508
91EWS_26573619_Chip-Seq_HEK293_Human1.14095495
92P300_18555785_Chip-Seq_ESCs_Mouse1.13910376
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13453673
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13290782
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12741948
96FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11733470
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10850924
98HTT_18923047_ChIP-ChIP_STHdh_Human1.10423476
99KLF4_18555785_Chip-Seq_ESCs_Mouse1.09612587
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.09536914
101* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09030073
102MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08515767
103EOMES_21245162_ChIP-Seq_HESCs_Human1.08165322
104LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08042179
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07939224
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.07433932
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07231811
108SMAD4_21799915_ChIP-Seq_A2780_Human1.06478875
109FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06279725
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05740716
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05441211
112P53_22387025_ChIP-Seq_ESCs_Mouse1.05406356
113STAT3_18555785_Chip-Seq_ESCs_Mouse1.05159280
114TCF4_22108803_ChIP-Seq_LS180_Human1.04719718
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.03713843
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03591369
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03438276
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02583128
119TP53_18474530_ChIP-ChIP_U2OS_Human1.02234756
120SOX2_19829295_ChIP-Seq_ESCs_Human1.01106125
121NANOG_19829295_ChIP-Seq_ESCs_Human1.01106125
122SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.00950041
123POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99319728
124SOX2_18555785_Chip-Seq_ESCs_Mouse0.99049529
125LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98931082
126SMAD_19615063_ChIP-ChIP_OVARY_Human0.98794198
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97950858
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97903445
129CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97156382
130IGF1R_20145208_ChIP-Seq_DFB_Human0.95070748
131P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95041189
132RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93667612
133FLI1_27457419_Chip-Seq_LIVER_Mouse0.92944359
134* STAT3_23295773_ChIP-Seq_U87_Human0.92250132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.14472459
2MP0003880_abnormal_central_pattern4.12787029
3MP0003950_abnormal_plasma_membrane3.07734666
4MP0001529_abnormal_vocalization3.06462029
5MP0005171_absent_coat_pigmentation3.02698380
6MP0003690_abnormal_glial_cell2.78508998
7MP0001905_abnormal_dopamine_level2.75069430
8MP0004270_analgesia2.75033667
9MP0001984_abnormal_olfaction2.66125625
10MP0004742_abnormal_vestibular_system2.46812884
11MP0004142_abnormal_muscle_tone2.34915446
12MP0002272_abnormal_nervous_system2.25983787
13MP0003136_yellow_coat_color2.16042255
14MP0000383_abnormal_hair_follicle2.14705983
15MP0003634_abnormal_glial_cell2.12682881
16MP0003329_amyloid_beta_deposits2.04906977
17MP0004885_abnormal_endolymph2.02345918
18MP0001486_abnormal_startle_reflex2.00962221
19MP0002064_seizures1.97760923
20MP0004134_abnormal_chest_morphology1.93475115
21MP0000778_abnormal_nervous_system1.83105538
22MP0004381_abnormal_hair_follicle1.82533717
23MP0010678_abnormal_skin_adnexa1.77778531
24MP0001346_abnormal_lacrimal_gland1.77410466
25MP0001485_abnormal_pinna_reflex1.76710786
26MP0002734_abnormal_mechanical_nocicepti1.66173336
27MP0005409_darkened_coat_color1.64708062
28MP0008260_abnormal_autophagy1.64544725
29MP0009046_muscle_twitch1.54260923
30MP0005423_abnormal_somatic_nervous1.51788520
31MP0009745_abnormal_behavioral_response1.50841316
32MP0002229_neurodegeneration1.50662672
33MP0001502_abnormal_circadian_rhythm1.48642348
34MP0003632_abnormal_nervous_system1.47646847
35MP0001299_abnormal_eye_distance/1.45785635
36MP0002638_abnormal_pupillary_reflex1.43909730
37MP0005671_abnormal_response_to1.41130901
38MP0005410_abnormal_fertilization1.36218749
39MP0004811_abnormal_neuron_physiology1.34817100
40MP0000462_abnormal_digestive_system1.33856418
41MP0005451_abnormal_body_composition1.33118472
42MP0006082_CNS_inflammation1.32235450
43MP0003635_abnormal_synaptic_transmissio1.30087196
44MP0003787_abnormal_imprinting1.26995014
45MP0001440_abnormal_grooming_behavior1.26086481
46MP0002557_abnormal_social/conspecific_i1.23755842
47MP0004043_abnormal_pH_regulation1.22942500
48MP0009250_abnormal_appendicular_skeleto1.22110539
49MP0002572_abnormal_emotion/affect_behav1.21196404
50MP0004859_abnormal_synaptic_plasticity1.21007965
51MP0002822_catalepsy1.19974938
52MP0008569_lethality_at_weaning1.18793548
53MP0000569_abnormal_digit_pigmentation1.18440569
54MP0003045_fibrosis1.18330363
55MP0000762_abnormal_tongue_morphology1.18037076
56MP0001970_abnormal_pain_threshold1.18001710
57MP0003631_nervous_system_phenotype1.16771285
58MP0002882_abnormal_neuron_morphology1.15811403
59MP0001963_abnormal_hearing_physiology1.15433246
60MP0008877_abnormal_DNA_methylation1.15171631
61MP0000566_synostosis1.15128225
62MP0005167_abnormal_blood-brain_barrier1.14261489
63MP0005253_abnormal_eye_physiology1.14027669
64MP0005551_abnormal_eye_electrophysiolog1.14012266
65MP0008438_abnormal_cutaneous_collagen1.13830412
66MP0001348_abnormal_lacrimal_gland1.13346678
67MP0000955_abnormal_spinal_cord1.11517302
68MP0000372_irregular_coat_pigmentation1.10911418
69MP0004147_increased_porphyrin_level1.10483193
70MP0002933_joint_inflammation1.09787180
71MP0002148_abnormal_hypersensitivity_rea1.07651901
72MP0005623_abnormal_meninges_morphology1.07575155
73MP0003195_calcinosis1.05991939
74MP0002066_abnormal_motor_capabilities/c1.05565095
75MP0002295_abnormal_pulmonary_circulatio1.04333485
76MP0002067_abnormal_sensory_capabilities1.02338136
77MP0002063_abnormal_learning/memory/cond1.01501486
78MP0004924_abnormal_behavior1.00119333
79MP0005386_behavior/neurological_phenoty1.00119333
80MP0006276_abnormal_autonomic_nervous0.99621700
81MP0002752_abnormal_somatic_nervous0.97814403
82MP0000749_muscle_degeneration0.97592262
83MP0001851_eye_inflammation0.97327418
84MP0000604_amyloidosis0.96761569
85MP0009780_abnormal_chondrocyte_physiolo0.96565048
86MP0001177_atelectasis0.95756879
87MP0002735_abnormal_chemical_nociception0.95555289
88MP0000579_abnormal_nail_morphology0.95488074
89MP0003633_abnormal_nervous_system0.94980318
90MP0005645_abnormal_hypothalamus_physiol0.93881541
91MP0001986_abnormal_taste_sensitivity0.93281639
92MP0003183_abnormal_peptide_metabolism0.92004780
93MP0000647_abnormal_sebaceous_gland0.89003356
94MP0000026_abnormal_inner_ear0.88773681
95MP0005408_hypopigmentation0.88751902
96MP0002736_abnormal_nociception_after0.88238781
97MP0002733_abnormal_thermal_nociception0.88168101
98MP0002184_abnormal_innervation0.87632760
99MP0005646_abnormal_pituitary_gland0.86017820
100MP0003075_altered_response_to0.84726614
101MP0006072_abnormal_retinal_apoptosis0.81518721
102MP0008873_increased_physiological_sensi0.80924976
103MP0001968_abnormal_touch/_nociception0.79991024
104MP0004215_abnormal_myocardial_fiber0.79328086
105MP0002909_abnormal_adrenal_gland0.77536499
106MP0003938_abnormal_ear_development0.76962373
107MP0000639_abnormal_adrenal_gland0.76687226
108MP0008872_abnormal_physiological_respon0.75673977
109MP0005195_abnormal_posterior_eye0.74940404
110MP0002152_abnormal_brain_morphology0.74826102
111MP0005503_abnormal_tendon_morphology0.74522910
112MP0001188_hyperpigmentation0.74348301
113MP0009384_cardiac_valve_regurgitation0.73783678
114MP0008874_decreased_physiological_sensi0.73589866
115MP0003937_abnormal_limbs/digits/tail_de0.72717663
116MP0005058_abnormal_lysosome_morphology0.71302713
117MP0005379_endocrine/exocrine_gland_phen0.71207863
118MP0002163_abnormal_gland_morphology0.71192331
119MP0002090_abnormal_vision0.70066537
120MP0000467_abnormal_esophagus_morphology0.67961836
121MP0005388_respiratory_system_phenotype0.67914385
122MP0002133_abnormal_respiratory_system0.67914385
123MP0003137_abnormal_impulse_conducting0.67835588
124MP0003724_increased_susceptibility_to0.67835570
125MP0001340_abnormal_eyelid_morphology0.65215082
126MP0001501_abnormal_sleep_pattern0.63718426
127MP0002069_abnormal_eating/drinking_beha0.60626142
128MP0003866_abnormal_defecation0.60460157
129MP0002083_premature_death0.52402280
130MP0003879_abnormal_hair_cell0.51646791
131MP0005166_decreased_susceptibility_to0.51157763
132MP0005535_abnormal_body_temperature0.50940034
133MP0003763_abnormal_thymus_physiology0.49775996
134MP0005165_increased_susceptibility_to0.49298359
135MP0002102_abnormal_ear_morphology0.48258881
136MP0002234_abnormal_pharynx_morphology0.45244801
137MP0000427_abnormal_hair_cycle0.45178257
138MP0002095_abnormal_skin_pigmentation0.43017079

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.47857697
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.47857697
3Parakeratosis (HP:0001036)5.45554599
4Focal motor seizures (HP:0011153)5.29566817
5Neurofibrillary tangles (HP:0002185)5.19580983
6Action tremor (HP:0002345)4.93125934
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.34503732
8Cerebral hypomyelination (HP:0006808)4.20878359
9Febrile seizures (HP:0002373)4.17364737
10Atonic seizures (HP:0010819)4.12801854
11Diplopia (HP:0000651)4.08897821
12Abnormality of binocular vision (HP:0011514)4.08897821
13Focal seizures (HP:0007359)4.02807288
14Peripheral hypomyelination (HP:0007182)3.95176170
15Sensory axonal neuropathy (HP:0003390)3.93272022
16Increased serum pyruvate (HP:0003542)3.88960129
17Abnormality of glycolysis (HP:0004366)3.88960129
18Abnormality of the corticospinal tract (HP:0002492)3.68967737
19Hemiplegia (HP:0002301)3.56642737
20Epileptic encephalopathy (HP:0200134)3.38830787
21Cerebral inclusion bodies (HP:0100314)3.36207763
22Leukodystrophy (HP:0002415)3.16419671
23Hemiparesis (HP:0001269)3.11915525
24Choreoathetosis (HP:0001266)3.08277912
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.05337958
26Delusions (HP:0000746)3.02645394
27Congenital ichthyosiform erythroderma (HP:0007431)3.01076202
28Onion bulb formation (HP:0003383)3.00687958
29Ankle clonus (HP:0011448)2.96146924
30Amyotrophic lateral sclerosis (HP:0007354)2.95323811
31Pheochromocytoma (HP:0002666)2.93459144
32Spastic tetraparesis (HP:0001285)2.90723985
33Tetraplegia (HP:0002445)2.89679276
34Alacrima (HP:0000522)2.89409630
35White forelock (HP:0002211)2.89262946
36Neuroendocrine neoplasm (HP:0100634)2.84448880
37Patchy hypopigmentation of hair (HP:0011365)2.84212509
38Abnormal auditory evoked potentials (HP:0006958)2.82788290
39Increased circulating renin level (HP:0000848)2.81825604
40Urinary urgency (HP:0000012)2.80992910
41Supranuclear gaze palsy (HP:0000605)2.80264424
42Generalized tonic-clonic seizures (HP:0002069)2.79529500
43Morphological abnormality of the pyramidal tract (HP:0002062)2.78671268
44Dysdiadochokinesis (HP:0002075)2.78461157
45Retinal dysplasia (HP:0007973)2.78128663
46Papilledema (HP:0001085)2.75329088
47Abnormality of the phalanges of the 2nd finger (HP:0009541)2.73004258
48Lower limb muscle weakness (HP:0007340)2.73003161
49Abnormal eating behavior (HP:0100738)2.69017241
50Autoamputation (HP:0001218)2.66456481
51Dialeptic seizures (HP:0011146)2.59862915
52T lymphocytopenia (HP:0005403)2.57319191
53CNS hypomyelination (HP:0003429)2.55688818
54Spastic gait (HP:0002064)2.55610199
55Hypoplastic pelvis (HP:0008839)2.54414958
56Premature skin wrinkling (HP:0100678)2.54210803
57Segmental peripheral demyelination/remyelination (HP:0003481)2.52642198
58Progressive cerebellar ataxia (HP:0002073)2.52363148
59Thickened helices (HP:0000391)2.51295281
60Split foot (HP:0001839)2.50767859
61Impaired vibration sensation in the lower limbs (HP:0002166)2.50559151
62Akinesia (HP:0002304)2.49282305
63Anxiety (HP:0000739)2.47800065
64Vaginal atresia (HP:0000148)2.45301817
65Stridor (HP:0010307)2.44996029
66Absent septum pellucidum (HP:0001331)2.43594262
67Truncal ataxia (HP:0002078)2.42442895
68Absence seizures (HP:0002121)2.42162702
69Acute necrotizing encephalopathy (HP:0006965)2.41917855
70Dysmetria (HP:0001310)2.38142648
71Methylmalonic acidemia (HP:0002912)2.36522038
72Slow saccadic eye movements (HP:0000514)2.36226066
73Morphological abnormality of the inner ear (HP:0011390)2.35485565
74Termporal pattern (HP:0011008)2.34022291
75Insidious onset (HP:0003587)2.34022291
76Genital tract atresia (HP:0001827)2.33966892
77Abnormality of T cell number (HP:0011839)2.33451552
78Hepatosplenomegaly (HP:0001433)2.31025232
79Clonus (HP:0002169)2.27529273
80Torticollis (HP:0000473)2.27488885
81Cerebral hemorrhage (HP:0001342)2.26307314
82Mutism (HP:0002300)2.22968493
83Scanning speech (HP:0002168)2.20709836
84Clumsiness (HP:0002312)2.18329887
85Postural tremor (HP:0002174)2.18035734
86Aplasia involving bones of the upper limbs (HP:0009823)2.17605151
87Aplasia of the phalanges of the hand (HP:0009802)2.17605151
88Aplasia involving bones of the extremities (HP:0009825)2.17605151
89Decreased lacrimation (HP:0000633)2.15987149
903-Methylglutaconic aciduria (HP:0003535)2.14908836
91Megalencephaly (HP:0001355)2.08370300
92Abnormality of the septum pellucidum (HP:0007375)2.05405955
93Anteriorly placed anus (HP:0001545)2.05286949
94Metaphyseal dysplasia (HP:0100255)2.05049979
95Abnormality of incisor morphology (HP:0011063)2.04393203
96Intention tremor (HP:0002080)2.04198208
97Atrophy/Degeneration involving motor neurons (HP:0007373)2.03654609
98Poor speech (HP:0002465)2.03476961
99Medial flaring of the eyebrow (HP:0010747)2.02572729
100Urinary bladder sphincter dysfunction (HP:0002839)2.02345905
101Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.02288604
102Conical tooth (HP:0000698)2.01536944
103Abnormality of the periventricular white matter (HP:0002518)2.01180752
104Postural instability (HP:0002172)2.00282744
105Gait imbalance (HP:0002141)2.00116841
106Adrenal hypoplasia (HP:0000835)1.99013043
107Hypoplasia of the iris (HP:0007676)1.98296314
108Cupped ear (HP:0000378)1.97612488
109Abnormal mitochondria in muscle tissue (HP:0008316)1.97422795
110Myokymia (HP:0002411)1.97303944
111Gaze-evoked nystagmus (HP:0000640)1.97042593
112Broad-based gait (HP:0002136)1.96791379
113Prolonged neonatal jaundice (HP:0006579)1.96059050
114Mitochondrial inheritance (HP:0001427)1.94763973
115Hypoproteinemia (HP:0003075)1.94195558
116Renal Fanconi syndrome (HP:0001994)1.93635775
117Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.93419008
118Progressive macrocephaly (HP:0004481)1.92595950
119Focal dystonia (HP:0004373)1.92388835
120Coronal craniosynostosis (HP:0004440)1.91390183
121Limb dystonia (HP:0002451)1.89241027
122Humeroradial synostosis (HP:0003041)1.89078092
123Synostosis involving the elbow (HP:0003938)1.89078092
124Memory impairment (HP:0002354)1.88313999
125Spastic paraparesis (HP:0002313)1.87727125
126Status epilepticus (HP:0002133)1.87371065
127Muscular hypotonia of the trunk (HP:0008936)1.86585330
128Abnormality of the middle phalanges of the toes (HP:0010183)1.85491704
129Foot dorsiflexor weakness (HP:0009027)1.84832519
130Paraplegia (HP:0010550)1.83757290
131Spastic paraplegia (HP:0001258)1.83677043
132Partial duplication of thumb phalanx (HP:0009944)1.82255308
133IgG deficiency (HP:0004315)1.82161100
134Gowers sign (HP:0003391)1.80777027
135Congenital primary aphakia (HP:0007707)1.80547985
136Epiphyseal dysplasia (HP:0002656)1.80420148
137Metabolic alkalosis (HP:0200114)1.79952241
138Erythroderma (HP:0001019)1.79510329
139Septo-optic dysplasia (HP:0100842)1.77489932
140Absent speech (HP:0001344)1.77232319
141Craniofacial dystonia (HP:0012179)1.74184200
142Hepatocellular necrosis (HP:0001404)1.74139052
143Increased CSF protein (HP:0002922)1.73979107
144Acute encephalopathy (HP:0006846)1.73035154
145Rigidity (HP:0002063)1.71879979
146Mixed hearing impairment (HP:0000410)1.71504482
147Bradykinesia (HP:0002067)1.71488860
148Dysarthria (HP:0001260)1.71425892
149Hypokalemic alkalosis (HP:0001949)1.71163514
150Epileptiform EEG discharges (HP:0011182)1.70997804
151Progressive inability to walk (HP:0002505)1.70542198
152Abnormal hair whorl (HP:0010721)1.69770918
153Impaired vibratory sensation (HP:0002495)1.69721933
154Hypomagnesemia (HP:0002917)1.68806621
155Upper limb muscle weakness (HP:0003484)1.68442326
156Barrel-shaped chest (HP:0001552)1.67906849
157Infantile muscular hypotonia (HP:0008947)1.66420216
158Muscle fiber splitting (HP:0003555)1.66196427
159Abnormality of the foot musculature (HP:0001436)1.64823820
160Stomatitis (HP:0010280)1.64705161
161Postnatal microcephaly (HP:0005484)1.64563695
162Confusion (HP:0001289)1.64506649
163Abnormality of the 2nd finger (HP:0004100)1.64441890
164Gait ataxia (HP:0002066)1.64037370
165Diminished movement (HP:0002374)1.63998374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.75187714
2OXSR14.02135811
3PBK3.13251145
4BCR2.96836249
5EPHB12.93129698
6NTRK32.90563128
7LIMK12.89327678
8CASK2.72539628
9MST42.57906405
10MAPKAPK52.55346108
11PKN12.52321064
12CDK192.30754927
13TNIK2.15436446
14WNK42.10954309
15MAP3K122.01328327
16PRPF4B1.99244938
17TESK21.95858780
18DAPK21.94033348
19MINK11.90609540
20MET1.86213835
21TRIM281.81901774
22FGFR21.81631050
23CAMKK21.72496721
24NEK61.66186621
25PRKD31.52997668
26CSNK1G31.51208039
27MAP3K41.49642083
28CLK11.49516842
29NTRK11.47833547
30CAMK2B1.46114910
31UHMK11.44939845
32PINK11.43603053
33CAMKK11.42372340
34EIF2AK31.41468284
35CSNK1A1L1.37865379
36ROCK21.36122389
37MUSK1.35388769
38WNK11.31573477
39MAP4K21.30306887
40ERBB31.29306098
41CAMK2D1.24121873
42SGK2231.19667815
43SGK4941.19667815
44TSSK61.18739813
45DAPK11.17186538
46BMPR1B1.15930382
47CSNK1G11.13508219
48DYRK21.11494960
49TRPM71.11196489
50BUB11.00376939
51FGR0.99890981
52CAMK2G0.98940620
53PRKCG0.98697453
54CSNK1G20.92299938
55ARAF0.88743295
56PRKCE0.87801633
57PDK20.86956972
58MAP2K70.86348551
59MAP3K90.86171404
60CDK140.86161720
61GRK50.85018833
62TXK0.85005105
63MKNK10.84875721
64CAMK2A0.84319327
65ERBB40.84191118
66MAP3K130.83886599
67ITK0.82970704
68PLK20.82316997
69PAK30.81545916
70BMPR20.81372618
71ADRBK20.81307083
72FGFR10.81265675
73PRKCQ0.79965362
74MAPK130.79496531
75IRAK20.79129925
76KDR0.78321218
77IRAK10.76850065
78GRK70.76111479
79SIK30.75029874
80MAPK150.74728593
81MAP3K140.74267005
82EPHA40.72690184
83MARK10.70641982
84CDK180.69474744
85CDK150.68834693
86DAPK30.67732194
87BRSK10.67701469
88ILK0.67246273
89JAK10.63685275
90WNK30.60702702
91CDK50.60556502
92CDK11A0.60499846
93ACVR1B0.60175119
94BLK0.60007285
95ALK0.59487156
96TESK10.58573349
97PAK60.58320850
98STK160.57514365
99FRK0.56895809
100PHKG10.56724753
101PHKG20.56724753
102MAPK100.55451539
103IRAK40.55345514
104FES0.55057128
105VRK10.54688571
106INSRR0.53515351
107TYRO30.53394710
108PRKD10.52736178
109KSR10.50306296
110OBSCN0.49373512
111RPS6KA50.49134256
112PLK30.48560228
113PIK3CA0.46562538
114PRKG10.45705892
115PIM20.43701263
116CSNK1A10.43386386
117SGK10.43062623
118CAMK10.42320589
119RPS6KA30.42222863
120FYN0.42055802
121NME10.41232250
122EPHA30.40291503
123EIF2AK20.40057206
124PRKCA0.39180543
125YES10.37878162
126NTRK20.33534961
127MOS0.33297706
128MARK20.32755209
129PDPK10.32307863
130ICK0.31679906
131ADRBK10.30485915
132DYRK1A0.29348193
133GSK3A0.28509280
134PAK10.28179503
135IKBKB0.27791706
136PRKACA0.27083598
137LCK0.26773378
138PNCK0.26036230
139ROCK10.23947586
140MKNK20.23469394
141MAPKAPK20.22954266
142PRKCH0.22267606
143PRKACB0.22175517

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.48123297
2Steroid biosynthesis_Homo sapiens_hsa001004.40954938
3Fatty acid elongation_Homo sapiens_hsa000624.12010782
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.41735404
5Protein export_Homo sapiens_hsa030603.03335389
6Ether lipid metabolism_Homo sapiens_hsa005653.00312112
7Oxidative phosphorylation_Homo sapiens_hsa001902.66532096
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.65818516
9Amphetamine addiction_Homo sapiens_hsa050312.45358509
10Long-term potentiation_Homo sapiens_hsa047202.34526125
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.26626934
12Sulfur metabolism_Homo sapiens_hsa009202.04319508
13Insulin secretion_Homo sapiens_hsa049111.95981394
14Parkinsons disease_Homo sapiens_hsa050121.91744218
15Sphingolipid metabolism_Homo sapiens_hsa006001.90460094
16beta-Alanine metabolism_Homo sapiens_hsa004101.89065090
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.88864081
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85988740
19Vibrio cholerae infection_Homo sapiens_hsa051101.75957892
20Rheumatoid arthritis_Homo sapiens_hsa053231.72278586
21Collecting duct acid secretion_Homo sapiens_hsa049661.69500737
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.67613374
23Alzheimers disease_Homo sapiens_hsa050101.63067341
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.59015493
25Axon guidance_Homo sapiens_hsa043601.56987508
26Primary immunodeficiency_Homo sapiens_hsa053401.45440902
27Nitrogen metabolism_Homo sapiens_hsa009101.44553893
28Autoimmune thyroid disease_Homo sapiens_hsa053201.41346205
29Linoleic acid metabolism_Homo sapiens_hsa005911.41043378
30Olfactory transduction_Homo sapiens_hsa047401.38013179
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.37181592
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34127320
33Circadian rhythm_Homo sapiens_hsa047101.33022499
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31166353
35Serotonergic synapse_Homo sapiens_hsa047261.29739260
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28915803
37Oocyte meiosis_Homo sapiens_hsa041141.24344289
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21480616
39Phagosome_Homo sapiens_hsa041451.17829630
40cAMP signaling pathway_Homo sapiens_hsa040241.17423959
41Allograft rejection_Homo sapiens_hsa053301.16504658
42Graft-versus-host disease_Homo sapiens_hsa053321.15594208
43Arachidonic acid metabolism_Homo sapiens_hsa005901.13641624
44Calcium signaling pathway_Homo sapiens_hsa040201.13226877
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10982404
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10558818
47Folate biosynthesis_Homo sapiens_hsa007901.09190180
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05454895
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02549328
50Huntingtons disease_Homo sapiens_hsa050161.02253464
51Malaria_Homo sapiens_hsa051441.01683518
52Long-term depression_Homo sapiens_hsa047301.01289687
53Histidine metabolism_Homo sapiens_hsa003400.96560878
54Oxytocin signaling pathway_Homo sapiens_hsa049210.95389081
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92407950
56GABAergic synapse_Homo sapiens_hsa047270.90025117
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89852822
58Propanoate metabolism_Homo sapiens_hsa006400.87321280
59Phototransduction_Homo sapiens_hsa047440.87055095
60Renal cell carcinoma_Homo sapiens_hsa052110.86775587
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.85995946
62Proteasome_Homo sapiens_hsa030500.85948991
63Glutamatergic synapse_Homo sapiens_hsa047240.85403408
64T cell receptor signaling pathway_Homo sapiens_hsa046600.84462615
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83674699
66Lysosome_Homo sapiens_hsa041420.83266817
67Glutathione metabolism_Homo sapiens_hsa004800.82561943
68Vitamin B6 metabolism_Homo sapiens_hsa007500.82475926
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81421900
70Synaptic vesicle cycle_Homo sapiens_hsa047210.81326745
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81100779
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80087784
73Asthma_Homo sapiens_hsa053100.75755965
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74747114
75Tight junction_Homo sapiens_hsa045300.74465740
76Cardiac muscle contraction_Homo sapiens_hsa042600.73941518
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72513302
78Butanoate metabolism_Homo sapiens_hsa006500.72362281
79Cocaine addiction_Homo sapiens_hsa050300.71870783
80Antigen processing and presentation_Homo sapiens_hsa046120.71645617
81Morphine addiction_Homo sapiens_hsa050320.71267625
82Prion diseases_Homo sapiens_hsa050200.70336310
83Ras signaling pathway_Homo sapiens_hsa040140.69028551
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68415268
85Ovarian steroidogenesis_Homo sapiens_hsa049130.65899429
86Salmonella infection_Homo sapiens_hsa051320.60388146
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58716725
88Estrogen signaling pathway_Homo sapiens_hsa049150.58543828
89Endocytosis_Homo sapiens_hsa041440.58502207
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57604787
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55684101
92Arginine and proline metabolism_Homo sapiens_hsa003300.55058902
93Type I diabetes mellitus_Homo sapiens_hsa049400.53990594
94Gap junction_Homo sapiens_hsa045400.53978788
95Inositol phosphate metabolism_Homo sapiens_hsa005620.50300512
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.48789927
97Rap1 signaling pathway_Homo sapiens_hsa040150.48198619
98Dopaminergic synapse_Homo sapiens_hsa047280.47489081
99Basal transcription factors_Homo sapiens_hsa030220.47013937
100Pertussis_Homo sapiens_hsa051330.46612829
101Mineral absorption_Homo sapiens_hsa049780.46139773
102Bile secretion_Homo sapiens_hsa049760.45857528
103Thyroid hormone synthesis_Homo sapiens_hsa049180.45656025
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45433083
105Cholinergic synapse_Homo sapiens_hsa047250.43449332
106ECM-receptor interaction_Homo sapiens_hsa045120.43418940
107ABC transporters_Homo sapiens_hsa020100.42799923
108Nicotine addiction_Homo sapiens_hsa050330.42759420
109Circadian entrainment_Homo sapiens_hsa047130.42053037
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.41828739
111Chemokine signaling pathway_Homo sapiens_hsa040620.40626402
112ErbB signaling pathway_Homo sapiens_hsa040120.40484742
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39967305
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.39347950
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39012786
116African trypanosomiasis_Homo sapiens_hsa051430.35793145
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35784389
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35624563
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35298196
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35132858
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34324050
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34298668
123Peroxisome_Homo sapiens_hsa041460.33507399
124Gastric acid secretion_Homo sapiens_hsa049710.33226119
125Glioma_Homo sapiens_hsa052140.32428254
126RNA polymerase_Homo sapiens_hsa030200.32288655
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31619509
128Metabolic pathways_Homo sapiens_hsa011000.30861973
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30187067
130GnRH signaling pathway_Homo sapiens_hsa049120.29893361
131Melanogenesis_Homo sapiens_hsa049160.29864488
132Shigellosis_Homo sapiens_hsa051310.29701652
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29121949
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.28582446
135Salivary secretion_Homo sapiens_hsa049700.28141194
136Hedgehog signaling pathway_Homo sapiens_hsa043400.27917383
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27059791
138MAPK signaling pathway_Homo sapiens_hsa040100.24086041
139Taste transduction_Homo sapiens_hsa047420.23835506
140Regulation of autophagy_Homo sapiens_hsa041400.23526334
141Pancreatic secretion_Homo sapiens_hsa049720.23463712
142Renin secretion_Homo sapiens_hsa049240.23442014
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.23236045

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