CLEC10A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)5.57662947
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.57662947
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.57662947
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.57662947
5modulation by symbiont of host immune response (GO:0052553)5.57662947
6positive regulation by symbiont of host defense response (GO:0052509)5.57662947
7regulation of interferon-beta biosynthetic process (GO:0045357)5.27324740
8neutrophil activation involved in immune response (GO:0002283)5.13761673
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.07579238
10eosinophil chemotaxis (GO:0048245)5.04167505
11macrophage activation involved in immune response (GO:0002281)4.88133206
12pinocytosis (GO:0006907)4.73666466
13detection of other organism (GO:0098543)4.65031253
14negative regulation of granulocyte differentiation (GO:0030853)4.60891468
15adhesion of symbiont to host cell (GO:0044650)4.55956048
16virion attachment to host cell (GO:0019062)4.55956048
17B cell mediated immunity (GO:0019724)4.52607502
18detection of bacterium (GO:0016045)4.48077133
19eosinophil migration (GO:0072677)4.47096572
20regulation of B cell receptor signaling pathway (GO:0050855)4.26467353
21regulation of hypersensitivity (GO:0002883)4.24515382
22low-density lipoprotein particle clearance (GO:0034383)4.13685738
23microglial cell activation (GO:0001774)4.11696180
24positive regulation of interferon-alpha production (GO:0032727)4.10415828
25production of molecular mediator involved in inflammatory response (GO:0002532)4.08756973
26adhesion of symbiont to host (GO:0044406)4.04295521
27positive regulation of monocyte chemotaxis (GO:0090026)4.02583182
28positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.99245429
29immunoglobulin mediated immune response (GO:0016064)3.97228181
30detection of external biotic stimulus (GO:0098581)3.90113980
31regulation of dendritic cell antigen processing and presentation (GO:0002604)3.86991993
32response to peptidoglycan (GO:0032494)3.85429446
33regulation of interferon-alpha production (GO:0032647)3.84281699
34positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.76564410
35T-helper 1 type immune response (GO:0042088)3.76015317
36negative regulation of interleukin-12 production (GO:0032695)3.75004381
37antigen processing and presentation of endogenous antigen (GO:0019883)3.73421482
38lipoxygenase pathway (GO:0019372)3.72236059
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.69232252
40negative regulation of cell killing (GO:0031342)3.69232252
41cellular extravasation (GO:0045123)3.68769676
42regulation of cholesterol storage (GO:0010885)3.67875093
43positive regulation of type 2 immune response (GO:0002830)3.62210054
44regulation of gamma-delta T cell activation (GO:0046643)3.60832048
45macrophage activation (GO:0042116)3.60822617
46positive regulation of cholesterol efflux (GO:0010875)3.54430911
47cellular response to interferon-beta (GO:0035458)3.49899132
48negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.47874075
49regulation of T-helper 2 cell differentiation (GO:0045628)3.46608105
50glycosphingolipid catabolic process (GO:0046479)3.43710672
51positive thymic T cell selection (GO:0045059)3.43696645
52leukotriene metabolic process (GO:0006691)3.43627321
53detection of biotic stimulus (GO:0009595)3.42812890
54myeloid cell activation involved in immune response (GO:0002275)3.41238039
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.38869211
56antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.37601116
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.37601116
58negative regulation of phagocytosis (GO:0050765)3.37282417
59positive regulation of antigen processing and presentation (GO:0002579)3.33928777
60respiratory burst (GO:0045730)3.33742519
61regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.33676920
62negative thymic T cell selection (GO:0045060)3.33276532
63positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.31155511
64T cell costimulation (GO:0031295)3.30427170
65mannose metabolic process (GO:0006013)3.30193228
66regulation of monocyte chemotaxis (GO:0090025)3.28252775
67regulation of mast cell degranulation (GO:0043304)3.28033520
68apoptotic cell clearance (GO:0043277)3.27357230
69lymphocyte costimulation (GO:0031294)3.26650600
70response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25493866
71response to host immune response (GO:0052572)3.25493866
72myeloid dendritic cell activation (GO:0001773)3.24887215
73growth hormone receptor signaling pathway (GO:0060396)3.23269868
74positive regulation of mast cell activation (GO:0033005)3.20202881
75cellular response to interferon-gamma (GO:0071346)3.19629566
76positive regulation of cellular amide metabolic process (GO:0034250)3.18211049
77regulation of gamma-delta T cell differentiation (GO:0045586)3.16122974
78regulation of T cell tolerance induction (GO:0002664)3.15302411
79regulation of type 2 immune response (GO:0002828)3.14832843
80positive regulation of regulated secretory pathway (GO:1903307)3.13926272
81response to muramyl dipeptide (GO:0032495)3.13648864
82detection of molecule of bacterial origin (GO:0032490)3.12672691
83positive regulation of cholesterol transport (GO:0032376)3.11789921
84positive regulation of sterol transport (GO:0032373)3.11789921
85glycolipid catabolic process (GO:0019377)3.11225316
86negative T cell selection (GO:0043383)3.11044918
87regulation of mast cell activation involved in immune response (GO:0033006)3.09350202
88interferon-gamma-mediated signaling pathway (GO:0060333)3.09031256
89regulation of mononuclear cell migration (GO:0071675)3.07753018
90leukotriene biosynthetic process (GO:0019370)3.07680397
91regulation of regulated secretory pathway (GO:1903305)3.06977778
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06715573
93complement activation, alternative pathway (GO:0006957)3.04018510
94neutrophil activation (GO:0042119)3.03492548
95regulation of inflammatory response to antigenic stimulus (GO:0002861)3.03465102
96positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.03331062
97regulation of macrophage chemotaxis (GO:0010758)3.01101381
98positive regulation of mast cell activation involved in immune response (GO:0033008)3.01038598
99positive regulation of mast cell degranulation (GO:0043306)3.01038598
100lymphocyte chemotaxis (GO:0048247)3.00083582
101negative regulation of T cell mediated immunity (GO:0002710)2.99759954
102regulation of mast cell activation (GO:0033003)2.99448682
103positive regulation of chemokine secretion (GO:0090197)2.99015877
104negative regulation of mast cell activation (GO:0033004)2.98812153
105cellular response to thyroid hormone stimulus (GO:0097067)2.98510691
106positive regulation of macrophage cytokine production (GO:0060907)2.97979713
107Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97318096
108granulocyte activation (GO:0036230)2.95246091
109positive regulation of interferon-beta production (GO:0032728)2.95082131
110lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94553481
111negative regulation of lipid storage (GO:0010888)2.94087312
112regulation of leukocyte degranulation (GO:0043300)2.93917637
113regulation of tolerance induction (GO:0002643)2.93326288
114positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.91556700
115response to host (GO:0075136)2.90938066
116response to host defenses (GO:0052200)2.90938066
117response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.90938066
118response to interferon-gamma (GO:0034341)2.90559384
119negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.90240816
120positive regulation of B cell differentiation (GO:0045579)2.87802251
121regulation of interleukin-2 biosynthetic process (GO:0045076)2.83147806
122leukocyte migration involved in inflammatory response (GO:0002523)2.82705882
123germinal center formation (GO:0002467)2.82493451
124response to protozoan (GO:0001562)2.81685433
125negative regulation of macrophage differentiation (GO:0045650)2.81465450
126peptide catabolic process (GO:0043171)2.81183317
127hyaluronan catabolic process (GO:0030214)2.80860395
128regulation of lymphocyte chemotaxis (GO:1901623)2.80835487
129regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.80134789
130regulation of myeloid leukocyte mediated immunity (GO:0002886)2.79585616
131positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.79248496
132negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.77896522
133regulation of sequestering of triglyceride (GO:0010889)2.77787022
134adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.77764646
135production of molecular mediator of immune response (GO:0002440)2.76429395
136phagocytosis, engulfment (GO:0006911)2.75543895
137monocyte chemotaxis (GO:0002548)2.75272673
138type I interferon signaling pathway (GO:0060337)2.75104847
139cellular response to type I interferon (GO:0071357)2.75104847
140myeloid dendritic cell differentiation (GO:0043011)2.74578756
141positive regulation of leukocyte degranulation (GO:0043302)2.74458736
142regulation of macrophage differentiation (GO:0045649)2.74076217
143positive regulation of lymphocyte migration (GO:2000403)2.73957993
144regulation of antigen processing and presentation (GO:0002577)2.73539310
145regulation of macrophage derived foam cell differentiation (GO:0010743)2.72549128
146positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.71200588
147positive regulation of gamma-delta T cell activation (GO:0046645)2.70538061
148cellular response to growth hormone stimulus (GO:0071378)2.69337502
149response to type I interferon (GO:0034340)2.69280843

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.64199040
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.07413074
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.10360563
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.48709560
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.22843449
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.72585960
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.56271674
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.16991957
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06010019
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.02304638
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.97939639
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.95226787
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.51139511
14GATA1_22025678_ChIP-Seq_K562_Human2.44457297
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.38754912
16BRD4_27068464_Chip-Seq_AML-cells_Mouse2.30128777
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28249334
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.27761022
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11712427
20* SPI1_23547873_ChIP-Seq_NB4_Human2.11054226
21* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.09162816
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.08622947
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.98169680
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.94447580
25VDR_24763502_ChIP-Seq_THP-1_Human1.92989084
26SCL_19346495_ChIP-Seq_HPC-7_Human1.91760080
27VDR_21846776_ChIP-Seq_THP-1_Human1.88300032
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84503141
29SPI1_23127762_ChIP-Seq_K562_Human1.81025818
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80880659
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78324558
32CLOCK_20551151_ChIP-Seq_293T_Human1.77646141
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76729019
34* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.73892703
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73419698
36VDR_24787735_ChIP-Seq_THP-1_Human1.69066543
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.67857746
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.66574962
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.65803649
40PU_27001747_Chip-Seq_BMDM_Mouse1.65452748
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62559256
42CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.62159938
43MAF_26560356_Chip-Seq_TH1_Human1.55010592
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.54679928
45CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.51434748
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49663316
47CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.49118372
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43847161
49RUNX_20019798_ChIP-Seq_JUKART_Human1.39437044
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39417698
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37668392
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37426253
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35720929
54MYB_26560356_Chip-Seq_TH2_Human1.32317177
55* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31649696
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30187560
57* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30100347
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30028335
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27825616
60* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24555346
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22089713
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20645451
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18978056
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.18654920
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17944035
66MYB_26560356_Chip-Seq_TH1_Human1.14567022
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13638537
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12860352
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12015029
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.10682446
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09787394
72* SPI1_20517297_ChIP-Seq_HL60_Human1.09320182
73TCF7_22412390_ChIP-Seq_EML_Mouse1.09167491
74GATA3_27048872_Chip-Seq_THYMUS_Human1.04836102
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04743427
76GATA3_26560356_Chip-Seq_TH2_Human1.00888259
77P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00273654
78E2F7_22180533_ChIP-Seq_HELA_Human0.99572987
79MYC_22102868_ChIP-Seq_BL_Human0.98520732
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97979724
81KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95881491
82GATA1_19941827_ChIP-Seq_MEL_Mouse0.95721800
83GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95720904
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94611674
85UTX_26944678_Chip-Seq_JUKART_Human0.94002107
86RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93532007
87GATA1_19941826_ChIP-Seq_K562_Human0.91726932
88PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90646620
89BCL6_27268052_Chip-Seq_Bcells_Human0.89924202
90LXR_22158963_ChIP-Seq_LIVER_Mouse0.89901002
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89345088
92EGR1_19032775_ChIP-ChIP_M12_Human0.89193454
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89065753
94GATA2_19941826_ChIP-Seq_K562_Human0.88471407
95* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87911626
96KDM2B_26808549_Chip-Seq_DND41_Human0.87474294
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87442572
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86999400
99RXR_22158963_ChIP-Seq_LIVER_Mouse0.81963041
100STAT1_20625510_ChIP-Seq_HELA_Human0.81238946
101SMRT_27268052_Chip-Seq_Bcells_Human0.80528649
102CJUN_26792858_Chip-Seq_BT549_Human0.80155400
103* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80125782
104FOXM1_23109430_ChIP-Seq_U2OS_Human0.80097744
105ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79924406
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79918025
107ESR1_21235772_ChIP-Seq_MCF-7_Human0.79435755
108TFEB_21752829_ChIP-Seq_HELA_Human0.79305617
109VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78338824
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.77294512
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76936774
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76760645
113MAF_26560356_Chip-Seq_TH2_Human0.76481133
114LXR_22292898_ChIP-Seq_THP-1_Human0.75729954
115RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75720269
116BCOR_27268052_Chip-Seq_Bcells_Human0.75136738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.81441156
2MP0001835_abnormal_antigen_presentation3.85218511
3MP0003436_decreased_susceptibility_to3.20237099
4MP0009840_abnormal_foam_cell3.10395759
5MP0003191_abnormal_cellular_cholesterol3.09465876
6MP0002419_abnormal_innate_immunity2.88398942
7MP0008438_abnormal_cutaneous_collagen2.86008169
8MP0002148_abnormal_hypersensitivity_rea2.78744311
9MP0003303_peritoneal_inflammation2.41604741
10MP0005025_abnormal_response_to2.41497955
11MP0005000_abnormal_immune_tolerance2.39287867
12MP0005670_abnormal_white_adipose2.26399193
13MP0009785_altered_susceptibility_to2.22935050
14MP0002452_abnormal_antigen_presenting2.19842163
15MP0001790_abnormal_immune_system2.17237734
16MP0005387_immune_system_phenotype2.17237734
17MP0000685_abnormal_immune_system2.16829583
18MP0000343_altered_response_to2.13737460
19MP0008004_abnormal_stomach_pH2.11161231
20MP0005275_abnormal_skin_tensile2.09415541
21MP0003690_abnormal_glial_cell2.06444743
22MP0003724_increased_susceptibility_to2.05155583
23MP0001800_abnormal_humoral_immune2.02624530
24MP0001853_heart_inflammation1.95602323
25MP0002723_abnormal_immune_serum1.92222753
26MP0001533_abnormal_skeleton_physiology1.91679169
27MP0005671_abnormal_response_to1.84120547
28MP0003172_abnormal_lysosome_physiology1.83229998
29MP0005464_abnormal_platelet_physiology1.81076524
30MP0001819_abnormal_immune_cell1.80761379
31MP0004510_myositis1.80267797
32MP0002420_abnormal_adaptive_immunity1.80214501
33MP0004185_abnormal_adipocyte_glucose1.77444271
34MP0000604_amyloidosis1.74197237
35MP0003705_abnormal_hypodermis_morpholog1.71761388
36MP0004130_abnormal_muscle_cell1.66795035
37MP0002405_respiratory_system_inflammati1.65542741
38MP0006082_CNS_inflammation1.65142682
39MP0003448_altered_tumor_morphology1.60610199
40MP0002254_reproductive_system_inflammat1.60566542
41MP0001845_abnormal_inflammatory_respons1.55661355
42MP0004947_skin_inflammation1.53422282
43MP0003828_pulmonary_edema1.53271245
44MP0005666_abnormal_adipose_tissue1.51291021
45MP0003075_altered_response_to1.51079332
46MP0008469_abnormal_protein_level1.43416707
47MP0009764_decreased_sensitivity_to1.36175828
48MP0003566_abnormal_cell_adhesion1.30822792
49MP0001958_emphysema1.30212799
50MP0005360_urolithiasis1.28673580
51MP0005647_abnormal_sex_gland1.28370100
52MP0002998_abnormal_bone_remodeling1.27202607
53MP0005310_abnormal_salivary_gland1.26842731
54MP0000465_gastrointestinal_hemorrhage1.22572652
55MP0003866_abnormal_defecation1.22210105
56* MP0000716_abnormal_immune_system1.21517822
57MP0001727_abnormal_embryo_implantation1.18886846
58MP0000569_abnormal_digit_pigmentation1.18582336
59MP0002909_abnormal_adrenal_gland1.18282629
60MP0002166_altered_tumor_susceptibility1.17104421
61MP0000689_abnormal_spleen_morphology1.17003691
62MP0010307_abnormal_tumor_latency1.13993091
63MP0002139_abnormal_hepatobiliary_system1.12327281
64MP0002138_abnormal_hepatobiliary_system1.11802613
65MP0010155_abnormal_intestine_physiology1.11157954
66MP0002876_abnormal_thyroid_physiology1.10216747
67MP0009333_abnormal_splenocyte_physiolog1.08407319
68MP0008260_abnormal_autophagy1.08261087
69MP0002006_tumorigenesis1.07987731
70MP0009115_abnormal_fat_cell1.07957713
71MP0001986_abnormal_taste_sensitivity1.07467883
72MP0000858_altered_metastatic_potential1.06383641
73MP0000015_abnormal_ear_pigmentation1.05185134
74* MP0002398_abnormal_bone_marrow1.03560306
75MP0001851_eye_inflammation1.03149151
76MP0000249_abnormal_blood_vessel1.02831812
77MP0003806_abnormal_nucleotide_metabolis1.02442034
78MP0002060_abnormal_skin_morphology1.00241337
79MP0002971_abnormal_brown_adipose0.99305802
80MP0010234_abnormal_vibrissa_follicle0.99155289
81* MP0002429_abnormal_blood_cell0.99076791
82MP0005451_abnormal_body_composition0.98503995
83MP0005379_endocrine/exocrine_gland_phen0.98180007
84MP0005375_adipose_tissue_phenotype0.97559403
85MP0002722_abnormal_immune_system0.97350315
86MP0005166_decreased_susceptibility_to0.96447721
87MP0000920_abnormal_myelination0.93090422
88MP0005174_abnormal_tail_pigmentation0.93003368
89MP0005334_abnormal_fat_pad0.92374065
90MP0003763_abnormal_thymus_physiology0.91324790
91MP0005164_abnormal_response_to0.90214710
92MP0003300_gastrointestinal_ulcer0.90008507
93MP0009763_increased_sensitivity_to0.89944416
94MP0004883_abnormal_blood_vessel0.89463525
95MP0010329_abnormal_lipoprotein_level0.88066583
96MP0000609_abnormal_liver_physiology0.86816916
97MP0005390_skeleton_phenotype0.86138934
98MP0003183_abnormal_peptide_metabolism0.84382128
99MP0002796_impaired_skin_barrier0.83907121
100MP0005397_hematopoietic_system_phenotyp0.82298106
101MP0001545_abnormal_hematopoietic_system0.82298106
102MP0002396_abnormal_hematopoietic_system0.82105503
103MP0005365_abnormal_bile_salt0.81071424
104MP0003279_aneurysm0.79010764
105MP0005257_abnormal_intraocular_pressure0.78539383
106MP0003795_abnormal_bone_structure0.78248168
107MP0002136_abnormal_kidney_physiology0.76933920
108MP0005319_abnormal_enzyme/_coenzyme0.75873172
109MP0001243_abnormal_dermal_layer0.75834519
110MP0001542_abnormal_bone_strength0.75612929
111MP0005165_increased_susceptibility_to0.74787048
112MP0001216_abnormal_epidermal_layer0.74528163
113MP0002132_abnormal_respiratory_system0.74455463
114MP0005075_abnormal_melanosome_morpholog0.74414528
115MP0004019_abnormal_vitamin_homeostasis0.74078253
116MP0003186_abnormal_redox_activity0.73121737
117MP0009278_abnormal_bone_marrow0.70809255
118MP0001915_intracranial_hemorrhage0.70514096
119MP0003453_abnormal_keratinocyte_physiol0.69561417
120MP0003091_abnormal_cell_migration0.68540173
121MP0002277_abnormal_respiratory_mucosa0.66260526
122MP0008874_decreased_physiological_sensi0.66238408
123MP0005076_abnormal_cell_differentiation0.66233686
124MP0001663_abnormal_digestive_system0.65809156
125MP0003879_abnormal_hair_cell0.65587117
126MP0000490_abnormal_crypts_of0.63036133
127MP0005584_abnormal_enzyme/coenzyme_acti0.61985749
128MP0000703_abnormal_thymus_morphology0.59340751
129MP0000371_diluted_coat_color0.57101430

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.94711932
2Recurrent abscess formation (HP:0002722)6.66630815
3Recurrent bacterial skin infections (HP:0005406)6.25907337
4Glomerulonephritis (HP:0000099)5.48310804
5Complement deficiency (HP:0004431)5.11162265
6Dysostosis multiplex (HP:0000943)4.92116291
7Increased cerebral lipofuscin (HP:0011813)4.87666361
8Eczematoid dermatitis (HP:0000976)4.86439657
9Abnormality of complement system (HP:0005339)4.70834282
10Vacuolated lymphocytes (HP:0001922)4.69720698
11Recurrent gram-negative bacterial infections (HP:0005420)4.40593632
12Increased neuronal autofluorescent lipopigment (HP:0002074)4.06175900
13Abnormality of glycolipid metabolism (HP:0010969)3.90660870
14Abnormality of liposaccharide metabolism (HP:0010968)3.90660870
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.90660870
16Disinhibition (HP:0000734)3.89177075
17Abnormality of macrophages (HP:0004311)3.85793127
18Recurrent cutaneous fungal infections (HP:0011370)3.82173882
19Chronic mucocutaneous candidiasis (HP:0002728)3.82173882
20Hematochezia (HP:0002573)3.76260342
21Amyloidosis (HP:0011034)3.50908421
22Urinary glycosaminoglycan excretion (HP:0003541)3.48419849
23Mucopolysacchariduria (HP:0008155)3.48419849
24Mediastinal lymphadenopathy (HP:0100721)3.45295043
25Axonal loss (HP:0003447)3.41175394
26Meningitis (HP:0001287)3.41143847
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.33475587
28Nephritis (HP:0000123)3.30045805
29Abnormality of mucopolysaccharide metabolism (HP:0011020)3.29857083
30Abnormality of polysaccharide metabolism (HP:0011012)3.29857083
31Abnormality of glycosaminoglycan metabolism (HP:0004371)3.29857083
32Neurofibrillary tangles (HP:0002185)3.27502089
33Recurrent skin infections (HP:0001581)3.24655416
34Mutism (HP:0002300)3.23615735
35Myocardial infarction (HP:0001658)3.19262902
36Prostate neoplasm (HP:0100787)3.18045281
37Asymmetric septal hypertrophy (HP:0001670)3.15879515
38Myositis (HP:0100614)3.15472615
39Thick nail (HP:0001805)3.09973877
40Hemoptysis (HP:0002105)3.09097033
41Colitis (HP:0002583)3.04646651
42Elevated erythrocyte sedimentation rate (HP:0003565)3.02656096
43Spondylolisthesis (HP:0003302)2.94373539
44Urticaria (HP:0001025)2.86398789
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.82580551
46Osteolytic defects of the hand bones (HP:0009699)2.82580551
47Chest pain (HP:0100749)2.75232651
48Gingivitis (HP:0000230)2.74587767
49Vasculitis (HP:0002633)2.73063028
50Spontaneous hematomas (HP:0007420)2.67268475
51Agnosia (HP:0010524)2.61381146
52Loss of speech (HP:0002371)2.54053099
53Hepatosplenomegaly (HP:0001433)2.53146748
54Cerebral inclusion bodies (HP:0100314)2.50439247
55Purpura (HP:0000979)2.50278636
56Autoimmune thrombocytopenia (HP:0001973)2.49360131
57Esophageal varix (HP:0002040)2.45980159
58Epistaxis (HP:0000421)2.45391875
59Recurrent fungal infections (HP:0002841)2.44965041
60Premature loss of primary teeth (HP:0006323)2.43926367
61Polygenic inheritance (HP:0010982)2.40644216
62Obstructive lung disease (HP:0006536)2.39579981
63Chronic obstructive pulmonary disease (HP:0006510)2.39579981
64Encephalitis (HP:0002383)2.38747512
65Pustule (HP:0200039)2.38744991
66Orchitis (HP:0100796)2.37999971
67Interstitial pulmonary disease (HP:0006530)2.36928972
68Abnormality of the vasculature of the conjunctiva (HP:0008054)2.36814683
69Malnutrition (HP:0004395)2.32212192
70Abnormal delayed hypersensitivity skin test (HP:0002963)2.31545634
71Petechiae (HP:0000967)2.31455217
72Recurrent viral infections (HP:0004429)2.29931554
73Upper motor neuron abnormality (HP:0002127)2.24256583
74Inflammation of the large intestine (HP:0002037)2.19357931
75Gingival bleeding (HP:0000225)2.18171087
76Polyneuropathy (HP:0001271)2.17546429
77Cheilitis (HP:0100825)2.17525030
78Progressive visual loss (HP:0000529)2.17030698
79Pulmonary embolism (HP:0002204)2.15663151
80Abnormality of the pleura (HP:0002103)2.15134862
81Thrombocytosis (HP:0001894)2.15081904
82Abnormality of the lumbar spine (HP:0100712)2.13857362
83Conjunctival telangiectasia (HP:0000524)2.12629252
84Cellulitis (HP:0100658)2.10878755
85Memory impairment (HP:0002354)2.09525837
86T lymphocytopenia (HP:0005403)2.09376630
87Protuberant abdomen (HP:0001538)2.09241757
88Periodontitis (HP:0000704)2.08730165
89Hypertriglyceridemia (HP:0002155)2.04585686
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04008802
91Gangrene (HP:0100758)2.03601936
92Amaurosis fugax (HP:0100576)2.03544384
93Mucosal telangiectasiae (HP:0100579)2.02461193
94Personality changes (HP:0000751)2.02377262
95Abnormality of the peritoneum (HP:0002585)2.01660435
96Xerostomia (HP:0000217)2.00682251
97Oligomenorrhea (HP:0000876)2.00146177
98Absent frontal sinuses (HP:0002688)1.97053093
99Gastrointestinal inflammation (HP:0004386)1.96074073
100Syringomyelia (HP:0003396)1.95830076
101Spinal cord lesions (HP:0100561)1.95830076
102Keratoconjunctivitis (HP:0001096)1.94438761
103Cerebral aneurysm (HP:0004944)1.94124639
104Vertigo (HP:0002321)1.93791785
105Steatorrhea (HP:0002570)1.93485516
106Diminished motivation (HP:0000745)1.93296297
107Basal ganglia calcification (HP:0002135)1.93114582
108Apathy (HP:0000741)1.89866862
109Joint stiffness (HP:0001387)1.88578169
110Bone cyst (HP:0012062)1.88532729
111Leukocytosis (HP:0001974)1.86478027
112Pulmonary infiltrates (HP:0002113)1.86199478
113Stomatitis (HP:0010280)1.83291885
114Peritonitis (HP:0002586)1.83071575
115Retrobulbar optic neuritis (HP:0100654)1.80319673
116Optic neuritis (HP:0100653)1.80319673
117Peripheral demyelination (HP:0011096)1.79961616
118Facial diplegia (HP:0001349)1.79471185
119Ovoid vertebral bodies (HP:0003300)1.77438329
120Supranuclear gaze palsy (HP:0000605)1.76920646
121Increased IgE level (HP:0003212)1.75688087
122Pathologic fracture (HP:0002756)1.75058884
123Keratoconjunctivitis sicca (HP:0001097)1.74873827
124Inappropriate behavior (HP:0000719)1.74828744
125Chronic otitis media (HP:0000389)1.74362651
126Abnormality of the prostate (HP:0008775)1.73500966
127Joint hemorrhage (HP:0005261)1.73333706
128Neuronal loss in central nervous system (HP:0002529)1.71395992
129Osteomyelitis (HP:0002754)1.69878450
130Arterial thrombosis (HP:0004420)1.69601944
131Gastrointestinal infarctions (HP:0005244)1.68495071
132Abnormality of nail color (HP:0100643)1.67662679
133Thoracic kyphosis (HP:0002942)1.67440234

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.04738811
2TYK24.79748817
3MAP3K133.24215643
4TGFBR23.16462573
5TRIB32.98661139
6IRAK32.98560535
7TBK12.80238249
8IRAK42.75262416
9RIPK42.45388071
10MAP3K142.43245479
11CAMK1D2.42393262
12CSF1R2.31000719
13KIT2.23563349
14CLK12.06697262
15STK102.04299812
16JAK12.01990248
17ERN12.01768426
18GRK72.01419589
19PRPF4B1.98477773
20MAP4K11.90048551
21FGR1.80252549
22TAOK31.78162800
23JAK31.75346231
24ARAF1.67566145
25SCYL21.57239629
26CSK1.53795778
27IKBKB1.47452242
28ZAP701.45511622
29MAP2K31.45151718
30TTN1.45057510
31CDK191.43320966
32CAMK1G1.43068718
33ITK1.42658046
34TXK1.36980493
35EPHB11.32356433
36RIPK11.31791246
37IKBKE1.31586454
38MET1.28794042
39BMX1.28518962
40KSR21.25220810
41MST1R1.23824128
42CDC42BPA1.22475764
43TNK21.22270278
44JAK21.19265634
45FES1.18838437
46MAP3K61.17554401
47MAP3K11.15207945
48BMPR1B1.13924156
49MAP3K101.13255537
50NEK91.12472784
51LRRK21.00612568
52TEC0.98946742
53MOS0.98536377
54FLT30.96518857
55HCK0.94612713
56STK240.92426101
57GRK60.92146839
58LCK0.92135777
59SYK0.91838504
60MARK30.89729072
61LYN0.88068252
62BTK0.85457330
63CDK60.81245853
64TESK20.79212577
65YES10.78923093
66EIF2AK20.75993731
67PIK3CG0.73070097
68MAPK70.70981432
69PKN20.69332754
70FGFR30.68163127
71EGFR0.67249524
72DMPK0.65648416
73TAOK10.65415998
74MAP3K90.65295941
75TRPM70.65103757
76CHUK0.64570218
77PRKCQ0.63211504
78PDGFRB0.60659941
79TAOK20.60574176
80MAPKAPK20.60365340
81MAPK120.60262569
82ACVR1B0.60054877
83MAP3K30.59726968
84CDK120.59490372
85ABL20.57641835
86MATK0.53009814
87PTK2B0.52429161
88BRSK20.50674330
89RPS6KA20.49155011
90MAPK40.47522311
91PRKCD0.47445742
92MAP3K20.47192212
93SIK30.45966957
94PTK60.44535049
95EEF2K0.44438727
96DAPK20.44327050
97IGF1R0.44314874
98RPS6KC10.43971127
99RPS6KL10.43971127
100RAF10.43926039
101MAP3K120.43395884
102RPS6KA40.42967560
103PDK10.42001573
104ABL10.41868810
105PKN10.40871340
106BMPR20.40849095
107MAP3K80.40337932
108PIM10.40327484
109KDR0.39571034
110CDK90.38840101
111IRAK10.37218576
112PDPK10.36654412
113STK40.36597095
114DYRK1B0.36446239
115STK30.34894926
116KSR10.34677544
117RET0.34464509
118PAK40.33944896
119GSK3A0.33764821
120SGK30.33696036
121RPS6KA60.33621917
122CAMKK20.33016609
123IRAK20.32896422
124PRKG20.32851146
125NME20.32505510
126PRKAA20.32033842
127PIK3CA0.31729897
128CAMKK10.30241889
129PIM20.29075958
130TGFBR10.28874018
131MARK20.28330438
132MAP3K110.26924201
133FYN0.26335173
134ADRBK20.25498964
135MAPK30.25337586
136NTRK10.25217473
137MAP3K50.24799460

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051505.06642339
2Other glycan degradation_Homo sapiens_hsa005113.88647191
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.76527327
4Lysosome_Homo sapiens_hsa041423.57827764
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.10743954
6Type I diabetes mellitus_Homo sapiens_hsa049403.05144543
7Leishmaniasis_Homo sapiens_hsa051402.81639969
8Pertussis_Homo sapiens_hsa051332.71532616
9Osteoclast differentiation_Homo sapiens_hsa043802.40876042
10Tuberculosis_Homo sapiens_hsa051522.30191274
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.27954978
12Phagosome_Homo sapiens_hsa041451.92360738
13Complement and coagulation cascades_Homo sapiens_hsa046101.91091521
14Legionellosis_Homo sapiens_hsa051341.87580112
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.69420164
16Caffeine metabolism_Homo sapiens_hsa002321.61986566
17Malaria_Homo sapiens_hsa051441.61639345
18Toxoplasmosis_Homo sapiens_hsa051451.59185107
19Antigen processing and presentation_Homo sapiens_hsa046121.52794678
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.52060136
21Chemokine signaling pathway_Homo sapiens_hsa040621.50748798
22Measles_Homo sapiens_hsa051621.48845920
23B cell receptor signaling pathway_Homo sapiens_hsa046621.46768717
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44557913
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.37975957
26Arachidonic acid metabolism_Homo sapiens_hsa005901.29795004
27PPAR signaling pathway_Homo sapiens_hsa033201.27419259
28Salmonella infection_Homo sapiens_hsa051321.22165830
29Rheumatoid arthritis_Homo sapiens_hsa053231.21682879
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20911882
31Apoptosis_Homo sapiens_hsa042101.20690229
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18122139
33Hematopoietic cell lineage_Homo sapiens_hsa046401.12760328
34Prion diseases_Homo sapiens_hsa050201.12753639
35Herpes simplex infection_Homo sapiens_hsa051681.09864938
36Influenza A_Homo sapiens_hsa051641.09605949
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.08926441
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.08066376
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06208514
40Graft-versus-host disease_Homo sapiens_hsa053321.06136280
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05652422
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05052723
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01295919
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99345295
45Intestinal immune network for IgA production_Homo sapiens_hsa046720.99015164
46Renin-angiotensin system_Homo sapiens_hsa046140.95038275
47Shigellosis_Homo sapiens_hsa051310.92294931
48Linoleic acid metabolism_Homo sapiens_hsa005910.91366291
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89964953
50Amoebiasis_Homo sapiens_hsa051460.89633594
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86849588
52Viral myocarditis_Homo sapiens_hsa054160.86614429
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.86359338
54TNF signaling pathway_Homo sapiens_hsa046680.85849314
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83421732
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81935647
57Platelet activation_Homo sapiens_hsa046110.81419868
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76073770
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75279145
60Sphingolipid metabolism_Homo sapiens_hsa006000.73097628
61T cell receptor signaling pathway_Homo sapiens_hsa046600.72916596
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71853252
63Hepatitis C_Homo sapiens_hsa051600.69857325
64Hepatitis B_Homo sapiens_hsa051610.67462247
65Asthma_Homo sapiens_hsa053100.66276206
66Endocytosis_Homo sapiens_hsa041440.65053299
67Primary immunodeficiency_Homo sapiens_hsa053400.64854104
68Ether lipid metabolism_Homo sapiens_hsa005650.61707904
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58651964
70Glycerolipid metabolism_Homo sapiens_hsa005610.58642563
71Allograft rejection_Homo sapiens_hsa053300.56641619
72Fatty acid biosynthesis_Homo sapiens_hsa000610.55505541
73African trypanosomiasis_Homo sapiens_hsa051430.54394213
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52823222
75Insulin resistance_Homo sapiens_hsa049310.52798045
76Acute myeloid leukemia_Homo sapiens_hsa052210.50192479
77Pentose phosphate pathway_Homo sapiens_hsa000300.49275943
78Pancreatic cancer_Homo sapiens_hsa052120.49007000
79HIF-1 signaling pathway_Homo sapiens_hsa040660.48669586
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45653314
81Collecting duct acid secretion_Homo sapiens_hsa049660.43786660
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.43760047
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.43630518
84beta-Alanine metabolism_Homo sapiens_hsa004100.43544196
85Fat digestion and absorption_Homo sapiens_hsa049750.43285967
86Chronic myeloid leukemia_Homo sapiens_hsa052200.42914543
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42413378
88Autoimmune thyroid disease_Homo sapiens_hsa053200.42220001
89VEGF signaling pathway_Homo sapiens_hsa043700.40981231
90HTLV-I infection_Homo sapiens_hsa051660.40428595
91Systemic lupus erythematosus_Homo sapiens_hsa053220.40106020
92Small cell lung cancer_Homo sapiens_hsa052220.38917258
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36967769
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.36799858
95Galactose metabolism_Homo sapiens_hsa000520.36468378
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36378076
97Epstein-Barr virus infection_Homo sapiens_hsa051690.36359423
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35834313
99Renal cell carcinoma_Homo sapiens_hsa052110.33146488
100ABC transporters_Homo sapiens_hsa020100.32525897
101Non-small cell lung cancer_Homo sapiens_hsa052230.26255818
102Viral carcinogenesis_Homo sapiens_hsa052030.25905625
103Adherens junction_Homo sapiens_hsa045200.24729624
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24479116
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.23924072
106Focal adhesion_Homo sapiens_hsa045100.23810745
107Prolactin signaling pathway_Homo sapiens_hsa049170.22847290
108Proteoglycans in cancer_Homo sapiens_hsa052050.22835872
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22619643
110GnRH signaling pathway_Homo sapiens_hsa049120.20580974
111Starch and sucrose metabolism_Homo sapiens_hsa005000.18447458
112Dorso-ventral axis formation_Homo sapiens_hsa043200.17599733
113Vibrio cholerae infection_Homo sapiens_hsa051100.16150447
114Renin secretion_Homo sapiens_hsa049240.14489000
115Histidine metabolism_Homo sapiens_hsa003400.09960440
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.08335580

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