CLEC11A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratan sulfate catabolic process (GO:0042340)9.98539606
2collagen fibril organization (GO:0030199)9.03420343
3bone trabecula formation (GO:0060346)7.59545864
4skin morphogenesis (GO:0043589)7.09204341
5chondrocyte development (GO:0002063)6.48727838
6collagen catabolic process (GO:0030574)6.22008191
7collagen metabolic process (GO:0032963)6.13762217
8cartilage development involved in endochondral bone morphogenesis (GO:0060351)6.03045320
9negative regulation of growth of symbiont in host (GO:0044130)5.94582531
10negative regulation of growth of symbiont involved in interaction with host (GO:0044146)5.94582531
11modulation of growth of symbiont involved in interaction with host (GO:0044144)5.94582531
12regulation of growth of symbiont in host (GO:0044126)5.94582531
13multicellular organismal macromolecule metabolic process (GO:0044259)5.75530720
14multicellular organismal catabolic process (GO:0044243)5.74225798
15tooth mineralization (GO:0034505)5.73288323
16regulation of chemokine biosynthetic process (GO:0045073)5.69002641
17cellular extravasation (GO:0045123)5.68282107
18neutrophil mediated immunity (GO:0002446)5.64068187
19killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.50884578
20disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.50884578
21peptidyl-proline hydroxylation (GO:0019511)5.48398499
22multicellular organismal metabolic process (GO:0044236)5.43439969
23cellular response to vitamin D (GO:0071305)5.42106080
24cellular response to vitamin (GO:0071295)5.28637828
25response to peptidoglycan (GO:0032494)5.24970589
26extracellular matrix disassembly (GO:0022617)4.97943739
27endodermal cell differentiation (GO:0035987)4.96559427
28chondrocyte proliferation (GO:0035988)4.86292571
29endothelial cell morphogenesis (GO:0001886)4.84145066
30negative regulation of erythrocyte differentiation (GO:0045647)4.80711513
31maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.73244195
32extracellular fibril organization (GO:0043206)4.72163518
33regulation of extracellular matrix disassembly (GO:0010715)4.68145405
34positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.67129490
35pinocytosis (GO:0006907)4.66151580
36COPI coating of Golgi vesicle (GO:0048205)4.63388594
37Golgi transport vesicle coating (GO:0048200)4.63388594
38negative regulation of phagocytosis (GO:0050765)4.62736063
39replacement ossification (GO:0036075)4.55662330
40endochondral ossification (GO:0001958)4.55662330
41deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.55457184
42biomineral tissue development (GO:0031214)4.55111809
43protein retention in ER lumen (GO:0006621)4.52563251
44positive regulation of B cell differentiation (GO:0045579)4.51510289
45regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.46528646
46protein hydroxylation (GO:0018126)4.44809338
47response to gravity (GO:0009629)4.38489664
48myeloid leukocyte mediated immunity (GO:0002444)4.36206700
49keratan sulfate biosynthetic process (GO:0018146)4.34763319
50extracellular matrix assembly (GO:0085029)4.32674254
51negative regulation of biomineral tissue development (GO:0070168)4.31123525
52fibril organization (GO:0097435)4.27270766
53negative regulation of interleukin-8 production (GO:0032717)4.24899560
54sequestering of extracellular ligand from receptor (GO:0035581)4.19955634
55planar cell polarity pathway involved in neural tube closure (GO:0090179)4.15169663
56positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.14608223
57protein trimerization (GO:0070206)4.05800592
58purine deoxyribonucleotide catabolic process (GO:0009155)4.02224714
59mannose metabolic process (GO:0006013)3.94690365
60response to muramyl dipeptide (GO:0032495)3.90379236
61extracellular matrix organization (GO:0030198)3.90359002
62response to BMP (GO:0071772)3.90268916
63cellular response to BMP stimulus (GO:0071773)3.90268916
64reactive oxygen species biosynthetic process (GO:1903409)3.89768444
65extracellular structure organization (GO:0043062)3.88771578
66adhesion of symbiont to host cell (GO:0044650)3.85603740
67virion attachment to host cell (GO:0019062)3.85603740
68positive regulation of chemokine biosynthetic process (GO:0045080)3.84859465
69UV protection (GO:0009650)3.84580760
70keratan sulfate metabolic process (GO:0042339)3.84134819
71negative regulation of B cell apoptotic process (GO:0002903)3.82853056
72regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.81850231
73positive regulation of extracellular matrix organization (GO:1903055)3.81733809
74regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.80087290
75mature B cell differentiation involved in immune response (GO:0002313)3.78770051
76neutrophil activation involved in immune response (GO:0002283)3.77346072
77ossification (GO:0001503)3.73612316
78macrophage differentiation (GO:0030225)3.73007583
79sulfur compound catabolic process (GO:0044273)3.62601092
80regulation of interleukin-8 biosynthetic process (GO:0045414)3.60289425
81negative regulation of chondrocyte differentiation (GO:0032331)3.59861311
82regulation of B cell apoptotic process (GO:0002902)3.57755868
83cell aggregation (GO:0098743)3.55872633
84cartilage condensation (GO:0001502)3.55872633
85dermatan sulfate biosynthetic process (GO:0030208)3.55461549
86blood vessel maturation (GO:0001955)3.53607283
87negative regulation of nitric oxide biosynthetic process (GO:0045019)3.50248981
88glycosaminoglycan catabolic process (GO:0006027)3.48409708
89bone morphogenesis (GO:0060349)3.47106749
90angiotensin maturation (GO:0002003)3.46236606
91skeletal system development (GO:0001501)3.45753824
92bone mineralization (GO:0030282)3.45338451
93COPII vesicle coating (GO:0048208)3.44168774
94regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.43238295
95deoxyribonucleotide catabolic process (GO:0009264)3.43197988
96regulation of biomineral tissue development (GO:0070167)3.39058721
97response to fungus (GO:0009620)3.37193342
98ribosomal small subunit biogenesis (GO:0042274)3.35002112
99deoxyribose phosphate catabolic process (GO:0046386)3.34588122
100regulation of mast cell degranulation (GO:0043304)3.31808962
101dermatan sulfate metabolic process (GO:0030205)3.31003081
102pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.30835657
103hydrogen peroxide catabolic process (GO:0042744)3.30452415
104glial cell migration (GO:0008347)3.30325920
105aminoglycan catabolic process (GO:0006026)3.29812116
106negative regulation of cartilage development (GO:0061037)3.29550049
107adhesion of symbiont to host (GO:0044406)3.29273015
108convergent extension (GO:0060026)3.26391461
109camera-type eye morphogenesis (GO:0048593)3.24310973
110glycosaminoglycan biosynthetic process (GO:0006024)3.21123914
111axon extension involved in axon guidance (GO:0048846)3.20883966
112neuron projection extension involved in neuron projection guidance (GO:1902284)3.20883966
113viral transcription (GO:0019083)3.20752642
114embryonic cranial skeleton morphogenesis (GO:0048701)3.20503739
115leukocyte mediated cytotoxicity (GO:0001909)3.20228891
116trabecula formation (GO:0060343)3.18783907
117regulation of vitamin D biosynthetic process (GO:0060556)3.18417082
118aminoglycan biosynthetic process (GO:0006023)3.18018467
119cellular response to amino acid stimulus (GO:0071230)3.17622686
120chondroitin sulfate biosynthetic process (GO:0030206)3.14914253
121negative regulation of JUN kinase activity (GO:0043508)3.13484905
122microglial cell activation (GO:0001774)3.12442367
123myoblast migration (GO:0051451)3.11057139
124regulation of myeloid leukocyte mediated immunity (GO:0002886)3.10668426
125Arp2/3 complex-mediated actin nucleation (GO:0034314)3.08100690
126respiratory burst (GO:0045730)3.07974976
127cartilage development (GO:0051216)3.06866931
128Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.06593537
129positive regulation of megakaryocyte differentiation (GO:0045654)3.06385222
130peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.04214087
131regulation of leukocyte degranulation (GO:0043300)3.03209032
132regulation of MHC class II biosynthetic process (GO:0045346)3.03092087
133regulation of extracellular matrix organization (GO:1903053)3.03024936
134regulation of bone mineralization (GO:0030500)3.02231357
135non-canonical Wnt signaling pathway (GO:0035567)3.01978879
136negative regulation of chemokine production (GO:0032682)3.01819073
137substrate-dependent cell migration (GO:0006929)3.01497777
138cell adhesion mediated by integrin (GO:0033627)3.00526361
139positive regulation of cartilage development (GO:0061036)2.97905377
140positive regulation of mesenchymal cell proliferation (GO:0002053)2.97356099
141response to vitamin D (GO:0033280)2.97121530
142positive regulation of tumor necrosis factor production (GO:0032760)2.95675524
143regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.95672938
144poly(A)+ mRNA export from nucleus (GO:0016973)2.95367770
145regulation of mast cell activation involved in immune response (GO:0033006)2.95049654
146positive regulation of gamma-delta T cell activation (GO:0046645)2.95036266
147autophagic vacuole fusion (GO:0000046)2.94823659
148definitive hemopoiesis (GO:0060216)2.92804817
149translational termination (GO:0006415)2.92134586
150regulation of establishment of planar polarity (GO:0090175)2.91032845
151cellular response to nutrient (GO:0031670)2.90817767
152negative regulation of granulocyte differentiation (GO:0030853)2.90007665
153negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.89465867
154positive regulation of catenin import into nucleus (GO:0035413)2.89059156
155ribosomal small subunit assembly (GO:0000028)2.88907892
156response to protozoan (GO:0001562)2.88715354
157positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.88704010
158craniofacial suture morphogenesis (GO:0097094)2.87443306
159middle ear morphogenesis (GO:0042474)2.87207810
160regulation of histone phosphorylation (GO:0033127)2.86751655
161G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.85931823
162purine deoxyribonucleotide metabolic process (GO:0009151)2.85654593
163positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.85162962
164response to thyroid hormone (GO:0097066)2.83930957
165deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.83912281
166positive regulation of epithelial to mesenchymal transition (GO:0010718)2.82135474
167regulation of tumor necrosis factor production (GO:0032680)2.81723251
168cellular response to interferon-beta (GO:0035458)2.81673351
169immunoglobulin mediated immune response (GO:0016064)2.81375151
170regulation of cartilage development (GO:0061035)2.79953262
1712-deoxyribonucleotide metabolic process (GO:0009394)2.79878856
172positive regulation of endothelial cell apoptotic process (GO:2000353)2.78689268
173mesenchymal-epithelial cell signaling (GO:0060638)2.78090768
174regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.78017111
175negative regulation of myeloid cell apoptotic process (GO:0033033)2.75734957
176hyaluronan catabolic process (GO:0030214)2.75054749
177pyrimidine nucleotide catabolic process (GO:0006244)2.73183106
178pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.72770255
179nucleotide salvage (GO:0043173)2.72637467
180defense response to fungus (GO:0050832)2.72383066
181purine nucleotide salvage (GO:0032261)2.71941522
182regulation of phagocytosis (GO:0050764)2.70833885
183dosage compensation (GO:0007549)2.68504901
184glycosphingolipid catabolic process (GO:0046479)2.68055421
185regulation of B cell differentiation (GO:0045577)2.67282587
186positive regulation of phagocytosis (GO:0050766)2.66982691
187pentose-phosphate shunt (GO:0006098)2.66709486
188cellular response to exogenous dsRNA (GO:0071360)2.65749691
189deoxyribose phosphate metabolic process (GO:0019692)2.64740434
1902-deoxyribonucleotide biosynthetic process (GO:0009265)2.64622316
191deoxyribose phosphate biosynthetic process (GO:0046385)2.64622316
192cellular response to thyroid hormone stimulus (GO:0097067)2.64262318
193phosphatidylglycerol biosynthetic process (GO:0006655)2.64046162
194regulation of response to osmotic stress (GO:0047484)2.62286664
195SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.61946715
196protein maturation by protein folding (GO:0022417)2.59515468
197negative regulation of monooxygenase activity (GO:0032769)2.59416085
198negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.56691235
199protein targeting to ER (GO:0045047)2.56621586
200protein heterotrimerization (GO:0070208)10.3176352

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.65528552
2* VDR_21846776_ChIP-Seq_THP-1_Human5.37254253
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse5.07934416
4RARG_19884340_ChIP-ChIP_MEFs_Mouse4.09154173
5TP63_17297297_ChIP-ChIP_HaCaT_Human4.06319794
6* VDR_24763502_ChIP-Seq_THP-1_Human3.68143512
7E2F7_22180533_ChIP-Seq_HELA_Human3.32197805
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.18545471
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.98634097
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.97238498
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.94141570
12CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.91408635
13CLOCK_20551151_ChIP-Seq_293T_Human2.88267413
14* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.87838543
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86969387
16SCL_19346495_ChIP-Seq_HPC-7_Human2.86526633
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.73571625
18* WT1_19549856_ChIP-ChIP_CCG9911_Human2.69309914
19AR_21572438_ChIP-Seq_LNCaP_Human2.69012038
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.67841053
21CJUN_26792858_Chip-Seq_BT549_Human2.51504404
22CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.49968936
23MYC_22102868_ChIP-Seq_BL_Human2.49657201
24ESR1_21235772_ChIP-Seq_MCF-7_Human2.47707065
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42554248
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.39406740
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.33539448
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32223646
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26027552
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.19610097
31* SPI1_23547873_ChIP-Seq_NB4_Human2.11664672
32* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.07952084
33NRF2_20460467_ChIP-Seq_MEFs_Mouse2.06834963
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.06834963
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04914064
36BRD4_25478319_ChIP-Seq_HGPS_Human1.96718170
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96697291
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95511570
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95511570
40* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94651705
41* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.92340636
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92248041
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.88863855
44UTX_26944678_Chip-Seq_JUKART_Human1.88822663
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88191034
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84306721
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82482111
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81244401
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.79795872
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.77403409
51* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76135755
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74739655
53GATA1_22025678_ChIP-Seq_K562_Human1.73434866
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.71217905
55TP53_18474530_ChIP-ChIP_U2OS_Human1.71097883
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70697360
57SMC1_22415368_ChIP-Seq_MEFs_Mouse1.70455928
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69669117
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68762877
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65871472
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62974147
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.62380165
63SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62323543
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.62089711
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.62043115
66MAF_26560356_Chip-Seq_TH1_Human1.59404504
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58489455
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57689901
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57442938
70TP53_20018659_ChIP-ChIP_R1E_Mouse1.56184155
71KDM2B_26808549_Chip-Seq_DND41_Human1.55976724
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55616268
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55383556
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54676416
75* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54360824
76SOX9_24532713_ChIP-Seq_HFSC_Mouse1.54252063
77* MAF_26560356_Chip-Seq_TH2_Human1.52820808
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48276733
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47366451
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47323378
81P68_20966046_ChIP-Seq_HELA_Human1.44213270
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.43556382
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.43508916
84SA1_22415368_ChIP-Seq_MEFs_Mouse1.42429533
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41646335
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41619394
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41186245
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40221570
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.38512506
90JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38136294
91STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37443698
92* BCL6_27268052_Chip-Seq_Bcells_Human1.36461964
93* TCF7_22412390_ChIP-Seq_EML_Mouse1.35691988
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35322115
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35221580
96SPI1_23127762_ChIP-Seq_K562_Human1.32693430
97SOX2_20726797_ChIP-Seq_SW620_Human1.32199761
98MYB_26560356_Chip-Seq_TH2_Human1.32002745
99ETS1_20019798_ChIP-Seq_JURKAT_Human1.30489253
100CIITA_25753668_ChIP-Seq_RAJI_Human1.30164483
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29070769
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28802590
103GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28193215
104TFEB_21752829_ChIP-Seq_HELA_Human1.27907076
105PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27631094
106* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27513523
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27184611
108CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26059510
109MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24898565
110CTCF_26484167_Chip-Seq_Bcells_Mouse1.24861989
111SMC3_22415368_ChIP-Seq_MEFs_Mouse1.24669927
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24314377
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24105904
114* SA1_27219007_Chip-Seq_ERYTHROID_Human1.24021450
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23577147
116MYB_26560356_Chip-Seq_TH1_Human1.23365299
117CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23076535
118ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22062505
119NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21047017
120ZNF263_19887448_ChIP-Seq_K562_Human1.21015679
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20993138
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20688294
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20544391
124NCOR1_26117541_ChIP-Seq_K562_Human1.20082248
125CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20026240
126PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19475298
127BCOR_27268052_Chip-Seq_Bcells_Human1.19002113
128VDR_24787735_ChIP-Seq_THP-1_Human1.17782782
129* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17530562
130* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17197431
131XRN2_22483619_ChIP-Seq_HELA_Human1.16438042
132IRF8_27001747_Chip-Seq_BMDM_Mouse1.16318241
133* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15941530
134RNF2_27304074_Chip-Seq_ESCs_Mouse1.15523070
135JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15304690
136CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13861936
137GABP_19822575_ChIP-Seq_HepG2_Human1.11813635
138CTCF_21964334_Chip-Seq_Bcells_Human1.11689031
139TBX20_22080862_ChIP-Seq_HEART_Mouse1.11537524
140TBX20_22328084_ChIP-Seq_HEART_Mouse1.11537524
141NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11273765
142THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11248844
143SRF_21415370_ChIP-Seq_HL-1_Mouse1.11000945
144MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10945891
145TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10927889
146MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09979550
147TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09829920
148CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09530052
149TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08480294
150SMAD_19615063_ChIP-ChIP_OVARY_Human1.08296398
151DCP1A_22483619_ChIP-Seq_HELA_Human1.08217314
152P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08005922
153UBF1/2_26484160_Chip-Seq_HMECs_Human1.07320717
154CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06839021
155RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06666476
156PIAS1_25552417_ChIP-Seq_VCAP_Human1.06040628
157GATA1_19941827_ChIP-Seq_MEL_Mouse1.05197122
158SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04138507
159ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04126498
160HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02781356
161TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02426457
162EGR1_19374776_ChIP-ChIP_THP-1_Human1.00585897
163NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99518764
164SPI1_20517297_ChIP-Seq_HL60_Human0.99252093
165CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98771126
166RXR_22108803_ChIP-Seq_LS180_Human0.98623126
167SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94377616
168RING1B_27294783_Chip-Seq_ESCs_Mouse0.93433391
169DROSHA_22980978_ChIP-Seq_HELA_Human0.93293979
170* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92762564
171GATA2_21666600_ChIP-Seq_HMVEC_Human0.92698928
172PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88453059
173TP53_23651856_ChIP-Seq_MEFs_Mouse0.88059705
174* ELK3_25401928_ChIP-Seq_HUVEC_Human0.87455183
175ISL1_27105846_Chip-Seq_CPCs_Mouse0.86873117
176ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86822837
177IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86314106
178SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85976994
179TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85056892
180P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83318224
181STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82361032
182HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82284560
183EZH2_27294783_Chip-Seq_ESCs_Mouse0.81712277
184NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.81700797
185ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.79963631
186SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79925356
187SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.79040570
188PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78458301
189ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78227544
190* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77772075
191* LXR_22292898_ChIP-Seq_THP-1_Human0.76725460
192SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76691050
193SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76691050
194THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76621232
195FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75708982
196KDM2B_26808549_Chip-Seq_K562_Human0.74906658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology9.01163928
2MP0008438_abnormal_cutaneous_collagen8.22860828
3MP0005275_abnormal_skin_tensile6.45907859
4MP0005058_abnormal_lysosome_morphology4.48586464
5MP0009278_abnormal_bone_marrow3.77608672
6MP0001542_abnormal_bone_strength3.70202200
7MP0005397_hematopoietic_system_phenotyp3.69261319
8MP0001545_abnormal_hematopoietic_system3.69261319
9MP0003172_abnormal_lysosome_physiology3.62848662
10MP0003303_peritoneal_inflammation3.62765832
11MP0005257_abnormal_intraocular_pressure3.09253091
12MP0006054_spinal_hemorrhage2.94566911
13MP0005508_abnormal_skeleton_morphology2.94071351
14MP0003436_decreased_susceptibility_to2.94064648
15MP0003279_aneurysm2.92585399
16MP0005464_abnormal_platelet_physiology2.82913247
17MP0002419_abnormal_innate_immunity2.81515368
18MP0002396_abnormal_hematopoietic_system2.77532266
19MP0002108_abnormal_muscle_morphology2.73007276
20MP0002896_abnormal_bone_mineralization2.58771261
21MP0005025_abnormal_response_to2.55398682
22MP0003705_abnormal_hypodermis_morpholog2.48276070
23MP0001835_abnormal_antigen_presentation2.45888600
24MP0001958_emphysema2.37954633
25MP0002933_joint_inflammation2.33885319
26MP0004808_abnormal_hematopoietic_stem2.30349773
27MP0009250_abnormal_appendicular_skeleto2.29448341
28MP0002148_abnormal_hypersensitivity_rea2.25628790
29MP0004134_abnormal_chest_morphology2.24723181
30MP0004272_abnormal_basement_membrane2.20602138
31MP0009384_cardiac_valve_regurgitation2.08777358
32MP0002060_abnormal_skin_morphology2.08054304
33MP0005390_skeleton_phenotype2.05765636
34MP0000163_abnormal_cartilage_morphology2.01964068
35MP0000013_abnormal_adipose_tissue1.98746098
36MP0002282_abnormal_trachea_morphology1.96261040
37MP0002115_abnormal_skeleton_extremities1.94139608
38MP0006082_CNS_inflammation1.88712611
39MP0001853_heart_inflammation1.85992288
40MP0002998_abnormal_bone_remodeling1.83961291
41MP0002420_abnormal_adaptive_immunity1.72975702
42MP0009785_altered_susceptibility_to1.71967767
43MP0001819_abnormal_immune_cell1.70998684
44MP0005000_abnormal_immune_tolerance1.70745908
45MP0003806_abnormal_nucleotide_metabolis1.65139285
46MP0004185_abnormal_adipocyte_glucose1.64095721
47MP0001533_abnormal_skeleton_physiology1.60744423
48MP0005451_abnormal_body_composition1.60653408
49MP0009840_abnormal_foam_cell1.58474901
50MP0005075_abnormal_melanosome_morpholog1.56354748
51MP0002452_abnormal_antigen_presenting1.54544514
52MP0002723_abnormal_immune_serum1.52645675
53MP0003283_abnormal_digestive_organ1.52559428
54MP0000465_gastrointestinal_hemorrhage1.52464695
55MP0002398_abnormal_bone_marrow1.52414604
56MP0005023_abnormal_wound_healing1.51104803
57MP0002113_abnormal_skeleton_development1.49827659
58MP0002722_abnormal_immune_system1.49710372
59MP0003656_abnormal_erythrocyte_physiolo1.49434693
60MP0002295_abnormal_pulmonary_circulatio1.48240147
61MP0001243_abnormal_dermal_layer1.48126199
62MP0000015_abnormal_ear_pigmentation1.48002924
63MP0003075_altered_response_to1.44535037
64MP0000751_myopathy1.44353479
65MP0000716_abnormal_immune_system1.41635530
66MP0000689_abnormal_spleen_morphology1.40239399
67MP0002837_dystrophic_cardiac_calcinosis1.38809841
68MP0003795_abnormal_bone_structure1.35825453
69MP0005174_abnormal_tail_pigmentation1.34784377
70MP0002429_abnormal_blood_cell1.34251556
71MP0003191_abnormal_cellular_cholesterol1.33609818
72MP0001800_abnormal_humoral_immune1.31937617
73MP0002405_respiratory_system_inflammati1.30810168
74MP0009764_decreased_sensitivity_to1.29227062
75MP0001845_abnormal_inflammatory_respons1.29071316
76MP0009780_abnormal_chondrocyte_physiolo1.28244032
77MP0002109_abnormal_limb_morphology1.27028394
78MP0003566_abnormal_cell_adhesion1.25566413
79MP0008469_abnormal_protein_level1.25091560
80MP0001299_abnormal_eye_distance/1.25057022
81MP0002932_abnormal_joint_morphology1.22310350
82MP0010030_abnormal_orbit_morphology1.21960852
83MP0003385_abnormal_body_wall1.20760567
84MP0008260_abnormal_autophagy1.17201970
85MP0009333_abnormal_splenocyte_physiolog1.16033169
86MP0000858_altered_metastatic_potential1.15179334
87MP0000681_abnormal_thyroid_gland1.14316013
88MP0006036_abnormal_mitochondrial_physio1.13585864
89MP0002019_abnormal_tumor_incidence1.11345150
90MP0005387_immune_system_phenotype1.07745460
91MP0001790_abnormal_immune_system1.07745460
92MP0000490_abnormal_crypts_of1.07573631
93MP0008007_abnormal_cellular_replicative1.07180238
94MP0000604_amyloidosis1.05822380
95MP0005165_increased_susceptibility_to1.03177820
96MP0003111_abnormal_nucleus_morphology1.01048246
97MP0000003_abnormal_adipose_tissue1.00097603
98MP0004147_increased_porphyrin_level1.00071588
99MP0009763_increased_sensitivity_to0.97079488
100MP0001270_distended_abdomen0.96397129
101MP0000762_abnormal_tongue_morphology0.96185315
102MP0003186_abnormal_redox_activity0.95219792
103MP0002249_abnormal_larynx_morphology0.94968509
104MP0002233_abnormal_nose_morphology0.93511081
105MP0000703_abnormal_thymus_morphology0.93398699
106MP0000049_abnormal_middle_ear0.92511351
107MP0003763_abnormal_thymus_physiology0.92199995
108MP0000462_abnormal_digestive_system0.91053977
109MP0010155_abnormal_intestine_physiology0.90985040
110MP0008873_increased_physiological_sensi0.90751078
111MP0003448_altered_tumor_morphology0.90152209
112MP0004947_skin_inflammation0.89757853
113MP0002116_abnormal_craniofacial_bone0.89417837
114MP0010307_abnormal_tumor_latency0.89334022
115MP0002877_abnormal_melanocyte_morpholog0.88892349
116MP0000428_abnormal_craniofacial_morphol0.88292518
117MP0000685_abnormal_immune_system0.86337631
118MP0005623_abnormal_meninges_morphology0.86016688
119MP0002089_abnormal_postnatal_growth/wei0.83782825
120MP0002111_abnormal_tail_morphology0.83033532
121MP0003828_pulmonary_edema0.82938702
122MP0009765_abnormal_xenobiotic_induced0.82647620
123MP0000358_abnormal_cell_content/0.82182218
124MP0000432_abnormal_head_morphology0.80771324
125MP0003935_abnormal_craniofacial_develop0.79520495
126MP0003755_abnormal_palate_morphology0.79127244
127MP0005375_adipose_tissue_phenotype0.79106083
128MP0003942_abnormal_urinary_system0.77881845
129MP0001851_eye_inflammation0.77654360
130MP0005220_abnormal_exocrine_pancreas0.77417806
131MP0010094_abnormal_chromosome_stability0.75811041
132MP0003183_abnormal_peptide_metabolism0.74869121
133MP0003786_premature_aging0.74868103
134MP0002114_abnormal_axial_skeleton0.74204214
135MP0005671_abnormal_response_to0.71633289
136MP0008004_abnormal_stomach_pH0.71609504
137MP0005360_urolithiasis0.71549266
138MP0000767_abnormal_smooth_muscle0.70109960
139MP0002095_abnormal_skin_pigmentation0.69745451
140MP0000516_abnormal_urinary_system0.69252352
141MP0005367_renal/urinary_system_phenotyp0.69252352
142MP0001764_abnormal_homeostasis0.69229972
143MP0002166_altered_tumor_susceptibility0.68536027
144MP0005369_muscle_phenotype0.68496490
145MP0010386_abnormal_urinary_bladder0.67148647
146MP0003115_abnormal_respiratory_system0.64728983
147MP0003122_maternal_imprinting0.64711833
148MP0003937_abnormal_limbs/digits/tail_de0.63020737
149MP0000534_abnormal_ureter_morphology0.62884719
150MP0003091_abnormal_cell_migration0.60924944
151MP0005595_abnormal_vascular_smooth0.59344838
152MP0005666_abnormal_adipose_tissue0.57464630
153MP0005164_abnormal_response_to0.54479113
154MP0000733_abnormal_muscle_development0.52196519
155MP0005193_abnormal_anterior_eye0.51800511
156MP0003724_increased_susceptibility_to0.51095986
157MP0003195_calcinosis0.49867770
158MP0001944_abnormal_pancreas_morphology0.48855771
159MP0000538_abnormal_urinary_bladder0.48454204
160MP0010771_integument_phenotype0.48276223
161MP0001346_abnormal_lacrimal_gland0.47872737
162MP0005076_abnormal_cell_differentiation0.46267584
163MP0001849_ear_inflammation0.45689743
164MP0010352_gastrointestinal_tract_polyps0.45201659
165MP0002168_other_aberrant_phenotype0.45023610
166MP0000343_altered_response_to0.43400602
167MP0003300_gastrointestinal_ulcer0.41964500
168MP0000613_abnormal_salivary_gland0.41904883
169MP0000678_abnormal_parathyroid_gland0.41745243
170MP0005197_abnormal_uvea_morphology0.40394542
171MP0001177_atelectasis0.40076452
172MP0002128_abnormal_blood_circulation0.39200425
173MP0009379_abnormal_foot_pigmentation0.38983287
174MP0003252_abnormal_bile_duct0.38403102
175MP0009053_abnormal_anal_canal0.37087267
176MP0002938_white_spotting0.36970577
177MP0001175_abnormal_lung_morphology0.36772876
178MP0002177_abnormal_outer_ear0.36218711
179MP0001614_abnormal_blood_vessel0.35156938

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)9.04411144
2Premature rupture of membranes (HP:0001788)7.30115158
3Thrombocytosis (HP:0001894)6.24941074
4Neonatal short-limb short stature (HP:0008921)5.65083318
5Biconcave vertebral bodies (HP:0004586)5.01919528
6Abnormality of dentin (HP:0010299)4.82211761
7Soft skin (HP:0000977)4.67609217
8Atrophic scars (HP:0001075)4.57791791
9Abnormality of glycolipid metabolism (HP:0010969)4.56458302
10Abnormality of liposaccharide metabolism (HP:0010968)4.56458302
11Abnormality of glycosphingolipid metabolism (HP:0004343)4.56458302
12Elevated erythrocyte sedimentation rate (HP:0003565)4.43231100
13Aortic dissection (HP:0002647)4.39768565
14Ankle contracture (HP:0006466)4.34657982
15Epiphyseal dysplasia (HP:0002656)4.34060623
16Small epiphyses (HP:0010585)4.18130691
17Peritonitis (HP:0002586)4.12688207
18Increased neuronal autofluorescent lipopigment (HP:0002074)4.11087376
19Obstructive lung disease (HP:0006536)4.07910484
20Chronic obstructive pulmonary disease (HP:0006510)4.07910484
21Dysostosis multiplex (HP:0000943)4.04398525
22Wormian bones (HP:0002645)4.03367164
23Follicular hyperkeratosis (HP:0007502)4.02783733
24Increased cerebral lipofuscin (HP:0011813)3.99644938
25Genu recurvatum (HP:0002816)3.91436783
26Broad metatarsal (HP:0001783)3.89462702
27Osteoarthritis (HP:0002758)3.89213665
28Cupped ribs (HP:0000887)3.82111810
29Mild short stature (HP:0003502)3.75856825
30Cervical subluxation (HP:0003308)3.75828271
31Shallow orbits (HP:0000586)3.58100234
32Blue sclerae (HP:0000592)3.55274243
33Vertebral compression fractures (HP:0002953)3.53831512
34Vacuolated lymphocytes (HP:0001922)3.53802340
35Granulocytopenia (HP:0001913)3.48705789
36Agammaglobulinemia (HP:0004432)3.42561862
37Hypoplastic ischia (HP:0003175)3.42227442
38Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.37662521
39Bladder diverticulum (HP:0000015)3.37601187
40Metaphyseal cupping (HP:0003021)3.32557704
41Fragile skin (HP:0001030)3.31548501
42Type 1 muscle fiber predominance (HP:0003803)3.27865871
43Petechiae (HP:0000967)3.26965580
44Recurrent abscess formation (HP:0002722)3.19446316
45B lymphocytopenia (HP:0010976)3.15665339
46Hepatosplenomegaly (HP:0001433)3.15314095
47Irregular epiphyses (HP:0010582)3.15248978
48Slender build (HP:0001533)3.13762977
49Platyspondyly (HP:0000926)3.10593300
50Cellulitis (HP:0100658)3.10475786
51Mitral valve prolapse (HP:0001634)3.09021673
52Loss of speech (HP:0002371)3.08080190
53Acute lymphatic leukemia (HP:0006721)3.07425475
54Abnormality of the acetabulum (HP:0003170)3.06709503
55Abnormality of the ischium (HP:0003174)3.03848154
56Abnormality of the prostate (HP:0008775)3.03691617
57Recurrent bacterial skin infections (HP:0005406)3.01658723
58Breech presentation (HP:0001623)3.00908654
59Thoracic kyphosis (HP:0002942)2.97335611
60Nonimmune hydrops fetalis (HP:0001790)2.96176202
61Abnormality of B cell number (HP:0010975)2.95576925
62Femoral bowing (HP:0002980)2.95043638
63Coxa vara (HP:0002812)2.92852293
64Tibial bowing (HP:0002982)2.87253933
65Irregular vertebral endplates (HP:0003301)2.86898170
66Ulnar bowing (HP:0003031)2.85855805
67Hyperextensible skin (HP:0000974)2.84639744
68Recurrent cutaneous fungal infections (HP:0011370)2.81707342
69Chronic mucocutaneous candidiasis (HP:0002728)2.81707342
70Dilatation of the ascending aorta (HP:0005111)2.81376994
71Abnormality of polysaccharide metabolism (HP:0011012)2.79489549
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.79489549
73Abnormality of mucopolysaccharide metabolism (HP:0011020)2.79489549
74Abnormal delivery (HP:0001787)2.77677301
75Amyloidosis (HP:0011034)2.76128442
76Increased serum ferritin (HP:0003281)2.75975677
77Abnormality of the vertebral endplates (HP:0005106)2.74374010
78Spondylolisthesis (HP:0003302)2.74242458
79Vitreoretinal degeneration (HP:0000655)2.73653992
80Ectopia lentis (HP:0001083)2.73116563
81Recurrent fungal infections (HP:0002841)2.72032789
82Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.71049454
83Flattened epiphyses (HP:0003071)2.69070624
84Meningitis (HP:0001287)2.66071515
85Broad ribs (HP:0000885)2.65043481
86Spinal rigidity (HP:0003306)2.64694929
87Epistaxis (HP:0000421)2.64040229
88Abnormality of macrophages (HP:0004311)2.61302247
89Abnormal tarsal ossification (HP:0008369)2.60610150
90Decreased skull ossification (HP:0004331)2.60283057
91Wide anterior fontanel (HP:0000260)2.59166672
92Morphological abnormality of the middle ear (HP:0008609)2.58000375
93Acute myeloid leukemia (HP:0004808)2.56498721
94Chest pain (HP:0100749)2.56344108
95Absent frontal sinuses (HP:0002688)2.55953398
96Beaking of vertebral bodies (HP:0004568)2.55521366
97Abnormal number of erythroid precursors (HP:0012131)2.53849385
98Urinary glycosaminoglycan excretion (HP:0003541)2.52958763
99Mucopolysacchariduria (HP:0008155)2.52958763
100Mediastinal lymphadenopathy (HP:0100721)2.51095699
101Hypertensive crisis (HP:0100735)2.50228488
102Genu varum (HP:0002970)2.48703297
103Abnormality of cells of the erythroid lineage (HP:0012130)2.46275254
104Myositis (HP:0100614)2.45764589
105Joint laxity (HP:0001388)2.43618124
106Periodontitis (HP:0000704)2.42974764
107Hypergammaglobulinemia (HP:0010702)2.42546370
108Purpura (HP:0000979)2.41078177
109Abnormality of the thoracic spine (HP:0100711)2.39322753
110Recurrent skin infections (HP:0001581)2.38350969
111Spinal cord compression (HP:0002176)2.37992109
112Aortic aneurysm (HP:0004942)2.37470799
113Infantile muscular hypotonia (HP:0008947)2.35615013
114Abnormality of skull ossification (HP:0002703)2.35190571
115Recurrent viral infections (HP:0004429)2.32095675
116Prolonged bleeding time (HP:0003010)2.31451749
117Panhypogammaglobulinemia (HP:0003139)2.29579201
118Abnormality of iron homeostasis (HP:0011031)2.29250955
119Reticulocytopenia (HP:0001896)2.27614431
120Eosinophilia (HP:0001880)2.27310651
121Delayed epiphyseal ossification (HP:0002663)2.27109433
122J-shaped sella turcica (HP:0002680)2.24934011
123Radial bowing (HP:0002986)2.24370433
124Wrist flexion contracture (HP:0001239)2.22684179
125Mesomelia (HP:0003027)2.21839481
126Thoracolumbar scoliosis (HP:0002944)2.21686445
127Systemic lupus erythematosus (HP:0002725)2.21646481
128Ovoid vertebral bodies (HP:0003300)2.21285809
129Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.16521727
130Stomatitis (HP:0010280)2.15803115
131Abnormality of the phalanges of the 2nd finger (HP:0009541)2.15777875
132Eczematoid dermatitis (HP:0000976)2.14063281
133Mildly elevated creatine phosphokinase (HP:0008180)2.13365077
134Metaphyseal irregularity (HP:0003025)2.10402938
135Bell-shaped thorax (HP:0001591)2.09955893
136Overgrowth (HP:0001548)2.09438916
137Flat capital femoral epiphysis (HP:0003370)2.08147902
138Skin rash (HP:0000988)2.07895730
139Bowing of the arm (HP:0006488)2.07508191
140Bowed forearm bones (HP:0003956)2.07508191
141Aortic regurgitation (HP:0001659)2.07061481
142Hemoptysis (HP:0002105)2.06741172
143Bowel diverticulosis (HP:0005222)2.06550141
144Abnormality of the heme biosynthetic pathway (HP:0010472)2.06308407
145Broad long bones (HP:0005622)2.06049587
146Leukocytosis (HP:0001974)2.05417820
147Hypoplasia of the odontoid process (HP:0003311)2.04857092
148Osteopenia (HP:0000938)2.03673512
149Abnormal platelet function (HP:0011869)2.03548381
150Impaired platelet aggregation (HP:0003540)2.03548381
151Cerebral aneurysm (HP:0004944)2.03294964
152Prolonged neonatal jaundice (HP:0006579)2.03185960
153Abnormal foot bone ossification (HP:0010675)2.01676839
154Osteolytic defects of the phalanges of the hand (HP:0009771)2.01401015
155Osteolytic defects of the hand bones (HP:0009699)2.01401015
156Microvesicular hepatic steatosis (HP:0001414)2.01336223
157Elbow flexion contracture (HP:0002987)2.00262024
158Increased variability in muscle fiber diameter (HP:0003557)2.00205685
159Sepsis (HP:0100806)1.99983341
160Deviation of the hallux (HP:0010051)1.99153210
161Increased connective tissue (HP:0009025)1.97865895
162Joint stiffness (HP:0001387)1.97722956
163Hallux valgus (HP:0001822)1.97325834
164Rhizomelia (HP:0008905)1.94957928
165Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94173830
166Abnormality of the 2nd finger (HP:0004100)1.92813598
167Abnormality of the odontoid process (HP:0003310)1.92615003
168Progressive neurologic deterioration (HP:0002344)1.92272253
169Abnormality of lateral ventricle (HP:0030047)1.92038770
170Lumbar hyperlordosis (HP:0002938)1.91761876
171Vascular tortuosity (HP:0004948)1.91679564
172Flat acetabular roof (HP:0003180)1.91084052
173Recurrent gram-negative bacterial infections (HP:0005420)1.89220772
174Centrally nucleated skeletal muscle fibers (HP:0003687)1.86018708
175Aplastic anemia (HP:0001915)1.85971270
176Autoimmune thrombocytopenia (HP:0001973)1.84811203
177Pulmonary fibrosis (HP:0002206)1.84707336
178Recurrent lower respiratory tract infections (HP:0002783)1.84686312
179Abnormality of transition element cation homeostasis (HP:0011030)1.84586094
180Abnormal delayed hypersensitivity skin test (HP:0002963)1.83111330
181Type I transferrin isoform profile (HP:0003642)1.81582380
182Osteomyelitis (HP:0002754)1.81310230
183Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81270870
184Neutropenia (HP:0001875)1.79749627
185Skin ulcer (HP:0200042)1.77298412
186Abnormality of the lumbar spine (HP:0100712)1.77296751
187Achilles tendon contracture (HP:0001771)1.76637949
188Abnormality of T cell physiology (HP:0011840)1.76332010
189Pulmonary infiltrates (HP:0002113)1.75344366
190Progressive muscle weakness (HP:0003323)1.75322507
191Upper motor neuron abnormality (HP:0002127)1.74840208
192Increased muscle lipid content (HP:0009058)1.73223518
193Decreased electroretinogram (ERG) amplitude (HP:0000654)1.70600674
194Increased IgE level (HP:0003212)1.70188066
195Gingivitis (HP:0000230)1.68682426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR28.51851321
2ERN14.53932139
3SIK14.00037600
4EPHA33.38521026
5TRIB33.10147289
6PDGFRA3.06195234
7TESK23.00662418
8BCKDK2.90128548
9VRK22.57311970
10PKN22.51654051
11KDR2.50801965
12MAP3K112.37490486
13FLT32.28378103
14TBK12.17324139
15SCYL22.15970839
16RIPK42.08256372
17TGFBR22.06650334
18FES2.00974173
19EPHB21.98817754
20LATS21.95006960
21LATS11.81567394
22TTN1.78559625
23MAP4K11.78444956
24IRAK31.74397951
25MAP3K31.71706531
26MAPK151.69955385
27FGFR21.64042609
28FER1.61816249
29PIK3CA1.55954372
30TNK21.46188762
31GRK71.41175630
32MAP3K141.39663635
33BTK1.33299927
34RIPK11.32616326
35FGFR11.26280025
36NME21.23711803
37PLK21.22999756
38STK38L1.22320707
39FRK1.22234094
40GRK61.21922520
41ARAF1.18818841
42TYK21.18439098
43TRPM71.18030208
44MYLK1.17320104
45IKBKB1.16875157
46NTRK11.14683998
47ZAP701.11708725
48PRPF4B1.10456943
49SYK1.09027386
50MATK1.08981840
51PAK21.05232393
52TAOK31.04081454
53CDK41.03759012
54PDGFRB0.99198161
55MET0.98913545
56STK30.98673710
57PAK40.98669657
58ICK0.98609076
59ADRBK10.98388245
60ROCK10.97486954
61SMG10.96196801
62MAP3K130.95617974
63MAP3K60.94279176
64ERBB30.94156463
65RPS6KA40.94064677
66PTK2B0.93550310
67PRKG20.93089476
68JAK10.91803588
69JAK30.89887205
70PIM20.89255874
71CDC70.88307710
72RPS6KC10.88278473
73RPS6KL10.88278473
74LRRK20.88099492
75KIT0.87552492
76PRKD20.86798947
77PTK20.86554364
78CDK120.83279485
79TAOK20.83212307
80LYN0.81123808
81RPS6KB20.80295411
82PRKD30.78363929
83TAOK10.78325840
84PTK60.76971393
85FGFR30.76686925
86MST1R0.76597594
87RPS6KA60.75106298
88PRKCH0.74341208
89CSF1R0.70846040
90PAK30.69797629
91PIK3CG0.69221227
92MAPK70.67776871
93MAP4K20.66842518
94DMPK0.66737237
95NEK90.66640528
96INSRR0.63478208
97DAPK10.62925126
98IKBKE0.61750328
99MAPK120.61326638
100HCK0.60709542
101CHEK20.60610080
102MAP2K60.59367452
103VRK10.58798625
104BLK0.58649887
105DAPK20.58604204
106ATR0.56065056
107EEF2K0.55689552
108RET0.55084518
109PRKCE0.55046281
110LCK0.54193824
111NUAK10.52266297
112TEC0.50884068
113MAP3K10.49427051
114IGF1R0.48650286
115FGFR40.48371633
116HIPK20.48146274
117BRAF0.47513829
118CASK0.47440538
119CDK70.47236130
120INSR0.47055366
121ILK0.46949354
122CDK60.46843975
123ITK0.46605314
124NME10.46246906
125RPS6KA20.46061848
126CDK80.45483829
127PRKD10.44874045
128AURKA0.44113627
129ROCK20.43254484
130MAP3K50.42922578
131PIM10.42020752
132MARK20.41111220
133PAK10.41092751
134MAP2K30.40644150
135EPHB10.40350273
136MAP2K10.40212312
137GSK3A0.39775060
138SRC0.39464842
139PDPK10.39081862
140BMPR20.38587736
141STK240.38280058
142MTOR0.37625875
143BMX0.37572190
144EIF2AK20.37118308
145IRAK40.36887925
146TESK10.36509653
147CDK90.35697008
148MAPKAPK50.34879454
149PRKCG0.34498893
150CLK10.33931507
151MAP3K100.32351241
152MAP3K80.31705521
153MAPK30.29949049
154CSK0.28126651
155MAPK110.27800823
156PDK40.27763169
157PDK30.27763169
158PRKCI0.26335035
159DYRK1B0.24072565
160MAPK10.22427617
161DAPK30.20041906
162MAPK40.19800333
163CAMKK20.19362447
164MOS0.18799076
165PDK20.18468332
166CDC42BPA0.18375391
167ABL20.17517649

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045126.77325871
2Protein digestion and absorption_Homo sapiens_hsa049745.25120479
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.42475136
4Focal adhesion_Homo sapiens_hsa045103.30586114
5DNA replication_Homo sapiens_hsa030302.77346247
6Ribosome_Homo sapiens_hsa030102.72438457
7Base excision repair_Homo sapiens_hsa034102.65748622
8Malaria_Homo sapiens_hsa051442.64456086
9Asthma_Homo sapiens_hsa053102.39366935
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.34872240
11Protein export_Homo sapiens_hsa030602.34564028
12Sulfur metabolism_Homo sapiens_hsa009202.10493483
13Acute myeloid leukemia_Homo sapiens_hsa052212.07465599
14PI3K-Akt signaling pathway_Homo sapiens_hsa041511.98185065
15Leishmaniasis_Homo sapiens_hsa051401.89643581
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86544570
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.84003158
18Amoebiasis_Homo sapiens_hsa051461.83146018
19TGF-beta signaling pathway_Homo sapiens_hsa043501.70927558
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.70222674
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.67572641
22Proteoglycans in cancer_Homo sapiens_hsa052051.64526583
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58732487
24Pentose phosphate pathway_Homo sapiens_hsa000301.57991169
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.53058391
26Pyrimidine metabolism_Homo sapiens_hsa002401.48207008
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.43882971
28Phototransduction_Homo sapiens_hsa047441.43358593
29N-Glycan biosynthesis_Homo sapiens_hsa005101.43132185
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42765997
31Bladder cancer_Homo sapiens_hsa052191.41994871
32Pertussis_Homo sapiens_hsa051331.41106626
33Primary immunodeficiency_Homo sapiens_hsa053401.41048847
34Basal cell carcinoma_Homo sapiens_hsa052171.39552874
35Caffeine metabolism_Homo sapiens_hsa002321.39264955
36Staphylococcus aureus infection_Homo sapiens_hsa051501.38660712
37Folate biosynthesis_Homo sapiens_hsa007901.38462752
38Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.37507633
39Tuberculosis_Homo sapiens_hsa051521.31578404
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31349840
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.29359952
42Dilated cardiomyopathy_Homo sapiens_hsa054141.28972077
43Vibrio cholerae infection_Homo sapiens_hsa051101.26497052
44Shigellosis_Homo sapiens_hsa051311.24766003
45Wnt signaling pathway_Homo sapiens_hsa043101.21727103
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21398469
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20144347
48B cell receptor signaling pathway_Homo sapiens_hsa046621.19698447
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19070747
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16061817
51Homologous recombination_Homo sapiens_hsa034401.14825872
52Hematopoietic cell lineage_Homo sapiens_hsa046401.12571700
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.11478820
54Phagosome_Homo sapiens_hsa041451.10652268
55Salmonella infection_Homo sapiens_hsa051321.07908833
56Renin-angiotensin system_Homo sapiens_hsa046141.04237349
57Antigen processing and presentation_Homo sapiens_hsa046121.03951651
58Systemic lupus erythematosus_Homo sapiens_hsa053220.98849162
59Hippo signaling pathway_Homo sapiens_hsa043900.98078530
60Thyroid hormone synthesis_Homo sapiens_hsa049180.96951013
61Hedgehog signaling pathway_Homo sapiens_hsa043400.96402259
62Melanogenesis_Homo sapiens_hsa049160.96066279
63Spliceosome_Homo sapiens_hsa030400.95304208
64Herpes simplex infection_Homo sapiens_hsa051680.95291935
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94860782
66Starch and sucrose metabolism_Homo sapiens_hsa005000.94655856
67Glutathione metabolism_Homo sapiens_hsa004800.94557558
68Platelet activation_Homo sapiens_hsa046110.93384466
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.92577179
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92559052
71Influenza A_Homo sapiens_hsa051640.92019574
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91706985
73Sulfur relay system_Homo sapiens_hsa041220.91522481
74Allograft rejection_Homo sapiens_hsa053300.90981866
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88590185
76Fanconi anemia pathway_Homo sapiens_hsa034600.87431266
77Oxidative phosphorylation_Homo sapiens_hsa001900.85529063
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85117582
79Arginine and proline metabolism_Homo sapiens_hsa003300.83081936
80Adherens junction_Homo sapiens_hsa045200.81372698
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.80611353
82MicroRNAs in cancer_Homo sapiens_hsa052060.79661584
83Legionellosis_Homo sapiens_hsa051340.79462229
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79361523
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79162988
86Melanoma_Homo sapiens_hsa052180.78197324
87Insulin resistance_Homo sapiens_hsa049310.77817435
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77304109
89Parkinsons disease_Homo sapiens_hsa050120.76464751
90Fatty acid elongation_Homo sapiens_hsa000620.75491805
91African trypanosomiasis_Homo sapiens_hsa051430.75075021
92Nucleotide excision repair_Homo sapiens_hsa034200.74594311
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72297299
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71727591
95Estrogen signaling pathway_Homo sapiens_hsa049150.69965606
96Mismatch repair_Homo sapiens_hsa034300.68580788
97Complement and coagulation cascades_Homo sapiens_hsa046100.66523756
98Prostate cancer_Homo sapiens_hsa052150.61803686
99Lysosome_Homo sapiens_hsa041420.61544238
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.61303413
101RNA polymerase_Homo sapiens_hsa030200.60836905
102Autoimmune thyroid disease_Homo sapiens_hsa053200.60696795
103Other glycan degradation_Homo sapiens_hsa005110.60479328
104Apoptosis_Homo sapiens_hsa042100.60296022
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60121110
106Graft-versus-host disease_Homo sapiens_hsa053320.58148708
107Epstein-Barr virus infection_Homo sapiens_hsa051690.57842200
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56606551
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55709522
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55697740
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55487296
112Huntingtons disease_Homo sapiens_hsa050160.55382548
113VEGF signaling pathway_Homo sapiens_hsa043700.54987311
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53087802
115Purine metabolism_Homo sapiens_hsa002300.52133675
116Pathways in cancer_Homo sapiens_hsa052000.51687868
117Glioma_Homo sapiens_hsa052140.51581875
118Rap1 signaling pathway_Homo sapiens_hsa040150.50377215
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.49765221
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49453500
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48687137
122Small cell lung cancer_Homo sapiens_hsa052220.47748002
123Non-small cell lung cancer_Homo sapiens_hsa052230.47552453
124Chronic myeloid leukemia_Homo sapiens_hsa052200.47075979
125Retinol metabolism_Homo sapiens_hsa008300.45673042
126Amphetamine addiction_Homo sapiens_hsa050310.45525165
127Rheumatoid arthritis_Homo sapiens_hsa053230.45168258
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43905993
129GnRH signaling pathway_Homo sapiens_hsa049120.43158554
130HTLV-I infection_Homo sapiens_hsa051660.43135536
131TNF signaling pathway_Homo sapiens_hsa046680.43097026
132Galactose metabolism_Homo sapiens_hsa000520.41789798
133Axon guidance_Homo sapiens_hsa043600.41708846
134Alzheimers disease_Homo sapiens_hsa050100.40455265
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.40441902
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40019888
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.39964096
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.39899647
139Gap junction_Homo sapiens_hsa045400.39723864
140Insulin secretion_Homo sapiens_hsa049110.38746107
141Fructose and mannose metabolism_Homo sapiens_hsa000510.37928872
142Glucagon signaling pathway_Homo sapiens_hsa049220.37907310
143Measles_Homo sapiens_hsa051620.37447923
144Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36196621
145Osteoclast differentiation_Homo sapiens_hsa043800.35817597
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.34320977
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33379037
148Viral carcinogenesis_Homo sapiens_hsa052030.33366132
149Cocaine addiction_Homo sapiens_hsa050300.32986538
150Toxoplasmosis_Homo sapiens_hsa051450.31880135
151Peroxisome_Homo sapiens_hsa041460.31800760
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.31458570
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31410034
154AMPK signaling pathway_Homo sapiens_hsa041520.27990730
155Lysine degradation_Homo sapiens_hsa003100.26968939
156Vascular smooth muscle contraction_Homo sapiens_hsa042700.25196044
157Selenocompound metabolism_Homo sapiens_hsa004500.23794808
158Leukocyte transendothelial migration_Homo sapiens_hsa046700.23543989
159Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.21717829
160Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21652038
161Hepatitis B_Homo sapiens_hsa051610.21435168
162Thyroid cancer_Homo sapiens_hsa052160.21375349
163Pancreatic cancer_Homo sapiens_hsa052120.21112083
164Olfactory transduction_Homo sapiens_hsa047400.20480003
165Sphingolipid metabolism_Homo sapiens_hsa006000.19697230
166Primary bile acid biosynthesis_Homo sapiens_hsa001200.17936161
167Dopaminergic synapse_Homo sapiens_hsa047280.17883204
168Prion diseases_Homo sapiens_hsa050200.17152071
169Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.15536342
170HIF-1 signaling pathway_Homo sapiens_hsa040660.15423728

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